Hui DS, Azhar I, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—the latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020;91:264–6.
Article
CAS
Google Scholar
Bogoch II, Watts A, Thomas-Bachli A, Huber C, Kraemer MUG, Khan K. Potential for global spread of a novel coronavirus from China. J Travel Med. 2020;27:taaa011.
Article
Google Scholar
de Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016;14:523–34.
Article
Google Scholar
Hu B, Ge X, Wang LF, Shi Z. Bat origin of human coronaviruses. Virol J. 2015;12:221.
Article
Google Scholar
Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, et al. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2015;21:1508–13.
Article
CAS
Google Scholar
To KK, Tsang OT, Chik-Yan YC, Chan KH, Wu TC, Chan JMC, et al. Consistent detection of 2019 novel coronavirus in saliva. Clin Infect Dis. 2020. https://doi.org/10.1093/cid/ciaa149.
Article
PubMed
PubMed Central
Google Scholar
Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. 2020;382:970–1.
Article
Google Scholar
Wolfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Muller MA, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020. https://doi.org/10.1038/s41586-020-2196-x.
Article
PubMed
Google Scholar
Reich E, Franklin RM, Shatkin AJ, Tatum EL. Effect of actinomycin D on cellular nucleic acid synthesis and virus production. Science. 1961;134:556–7.
Article
CAS
Google Scholar
Harwig A, Landick R, Berkhout B. The battle of RNA synthesis: virus versus host. Viruses. 2017;9:309.
Article
Google Scholar
Poch O, Sauvaget I, Delarue M, Tordo N. Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO J. 1989;8:3867–74.
Article
CAS
Google Scholar
Jia H, Gong P. A structure–function diversity survey of the RNA-dependent RNA polymerases from the positive-strand RNA viruses. Front Microbiol. 2019;10:1945.
Article
Google Scholar
Jacome R, Becerra A, de Ponce LS, Lazcano A. Structural analysis of monomeric RNA-dependent polymerases: evolutionary and therapeutic implications. PLoS ONE. 2015;10:e0139001.
Article
Google Scholar
Ng KK, Arnold JJ, Cameron CE. Structure–function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol. 2008;320:137–56.
CAS
PubMed
PubMed Central
Google Scholar
Lohmann V, Korner F, Herian U, Bartenschlager R. Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol. 1997;71:8416–28.
Article
CAS
Google Scholar
Vazquez AL, Alonso JM, Parra F. Mutation analysis of the GDD sequence motif of a calicivirus RNA-dependent RNA polymerase. J Virol. 2000;74:3888–91.
Article
CAS
Google Scholar
Pan J, Vakharia VN, Tao YJ. The structure of a birnavirus polymerase reveals a distinct active site topology. Proc Natl Acad Sci USA. 2007;104:7385–90.
Article
CAS
Google Scholar
Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016;531:381–5.
Article
CAS
Google Scholar
Furuta Y, Komeno T, Nakamura T. Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase. Proc Jpn Acad Ser B Phys Biol Sci. 2017;93:449–63.
Article
CAS
Google Scholar
Reynard O, Nguyen XN, Alazard-Dany N, Barateau V, Cimarelli A, Volchkov VE. Identification of a new ribonucleoside inhibitor of Ebola virus replication. Viruses. 2015;7:6233–40.
Article
CAS
Google Scholar
Bourliere M, Pietri O. Hepatitis C virus therapy: no one will be left behind. Int J Antimicrob Agents. 2019;53:755–60.
Article
CAS
Google Scholar
Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020. https://doi.org/10.1126/scitranslmed.abb5883.
Article
PubMed
PubMed Central
Google Scholar
Mendes EA, Pilger DRB, Santos Nastri ACS, Malta FM, Pascoalino BDS, Carneiro D’Albuquerque LA, et al. Sofosbuvir inhibits yellow fever virus in vitro and in patients with acute liver failure. Ann Hepatol. 2019;18:816–24.
Article
Google Scholar
Jiang W, Muhammad F, Ma P, Liu X, Long G. Sofosbuvir inhibits hepatitis A virus replication in vitro assessed by a cell-based fluorescent reporter system. Antivir Res. 2018;154:51–7.
Article
CAS
Google Scholar