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Clinical Translation

This section is closed to new submissions.

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

Featured articles

Tianzhi granule improves cognition and BPSD of vascular dementia

Research | Jing Shi et al


Tissue microRNAs in non-small cell lung cancer detected with a new kind of liquid bead array detection system​​​​​​​

Research | Yuan-Yuan Zheng et al


The clinical application of electrical impedance technology in the detection of malignant neoplasms

Review | Angela A. Pathiraja ​​​​​​​et al

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  1. Many HIV infected individuals with suppressed viral loads experience chronic immune activation frequently developing neurological impairment designated as HIV associated neurocognitive disorder (HAND). Adjunct...

    Authors: Jeffrey S. Barrett, Sergei Spitsin, Ganesh Moorthy, Kyle Barrett, Kate Baker, Andrew Lackner, Florin Tulic, Angela Winters, Dwight L. Evans and Steven D. Douglas
    Citation: Journal of Translational Medicine 2016 14:148
    Content type: Research Published on:

  2. Chronic fatigue syndrome (CFS) is a common and disabling disorder, and a major threat against adolescent health. The pathophysiology is unknown, but alteration of neuroendocrine control systems might be a cent...

    Authors: Vegard Bruun Wyller, Valieria Vitelli, Dag Sulheim, Even Fagermoen, Anette Winger, Kristin Godang and Jens Bollerslev
    Citation: Journal of Translational Medicine 2016 14:121
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:157

  4. SCLC has limited treatment options and inadequate preclinical models. Promising activity of arsenic trioxide (ASO) recorded in conventional preclinical models of SCLC supported the clinical evaluation of ASO i...

    Authors: Taofeek K. Owonikoko, Guojing Zhang, Hyun S. Kim, Renea M. Stinson, Rabih Bechara, Chao Zhang, Zhengjia Chen, Nabil F. Saba, Suchita Pakkala, Rathi Pillai, Xingming Deng, Shi-Yong Sun, Michael R. Rossi, Gabriel L. Sica, Suresh S. Ramalingam and Fadlo R. Khuri
    Citation: Journal of Translational Medicine 2016 14:111
    Content type: Research Published on:

  5. Acute appendicitis is a common cause for a visit to the emergency department and appendectomy represents the most common emergency procedure in surgery. The rate of negative appendectomy however has remained h...

    Authors: Peter C. Ambe, Daniel Gödde, Lars Bönicke, Marios Papadakis, Stephan Störkel and Hubert Zirngibl
    Citation: Journal of Translational Medicine 2016 14:107
    Content type: Research Published on:

  6. Compelling evidence has been accumulated to support the effectiveness of intensive lifestyle intervention in delaying progression to Type 2 diabetes even in people identified as being at high risk determined b...

    Authors: Bernardo Costa, Conxa Castell, Xavier Cos, Claustre Solé, Santiago Mestre, Marta Canela, Antoni Boquet, Joan-Josep Cabré, Francisco Barrio, Gemma Flores-Mateo, Daniel Ferrer-Vidal and Jaana Lindström
    Citation: Journal of Translational Medicine 2016 14:103
    Content type: Protocol Published on:

  8. BRAF V600 mutant circulating cell-free tumor DNA (BRAF V600mut ctDNA) could serve as a specific biomarker in patients with BRAF V600 mutant melanoma. We analyzed the value of BRAF V600...

    Authors: Max Schreuer, Geert Meersseman, Sari Van Den Herrewegen, Yanina Jansen, Ines Chevolet, Ambre Bott, Sofie Wilgenhof, Teofila Seremet, Bart Jacobs, Ronald Buyl, Geert Maertens and Bart Neyns
    Citation: Journal of Translational Medicine 2016 14:95
    Content type: Research Published on:

  9. Osteoarthritis (OA) is characterized by progressive loss of cartilage in joints, and is a major cause of pain and disability, and imposes significant health care expense. New therapies are being developed to t...

    Authors: Mohammad Haris, Anup Singh, Sanjana Reddy, Puneet Bagga, J. Bruce Kneeland, Fotios P. Tjoumakaris, Hari Hariharan, Francesco M. Marincola and Ravinder Reddy
    Citation: Journal of Translational Medicine 2016 14:92
    Content type: Research Published on:

  10. The mechanism of action of imatinib is known to involve the Fas-mediated apoptosis pathway. Consequently inter-individual variations in this apoptosis pathway might be associated with imatinib response or resi...

    Authors: Qiaoli Zheng, Jiang Cao, Nada Hamad, Hyeoung-Joon Kim, Joon Ho Moon, Sang Kyun Sohn, Chul Won Jung, Jeffrey H. Lipton and Dennis Dong Hwan Kim
    Citation: Journal of Translational Medicine 2016 14:82
    Content type: Research Published on:

  11. Typhoid fever, caused by the human-restricted organism Salmonella Typhi (S. Typhi), is a major public health problem worldwide. Development of novel vaccines remains imperative, but is hampered by an incomplete u...

    Authors: Stephanie Fresnay, Monica A. McArthur, Laurence Magder, Thomas C. Darton, Claire Jones, Claire S. Waddington, Christoph J. Blohmke, Brian Angus, Myron M. Levine, Andrew J. Pollard and Marcelo B. Sztein
    Citation: Journal of Translational Medicine 2016 14:62
    Content type: Research Published on:

  12. Kidney transplantation is the treatment of choice in patients with end stage renal disease. During kidney transplantation ischemia reperfusion injury (IRI) occurs, which is a risk factor for acute kidney injur...

    Authors: T. C. Saat, E. K. van den Akker, J. N. M. IJzermans, F. J. M. F. Dor and R. W. F. de Bruin
    Citation: Journal of Translational Medicine 2016 14:20
    Content type: Review Published on:

  13. Labour is perhaps the most hazardous time in pregnancy. As many as 20 % of cerebral palsy cases in term infants result from intrapartum events and up to 63 % of babies who develop intrapartum compromise have n...

    Authors: Liam Dunn, Vicki Flenady and Sailesh Kumar
    Citation: Journal of Translational Medicine 2016 14:15
    Content type: Protocol Published on:

  14. Clinical diagnostic research relies upon the collection of tissue samples, and for those samples to be representative of the in vivo situation. Tissue collection procedures, including post-operative ischemia, ...

    Authors: Florian T. Unger, Nicole Lange, Jana Krüger, Carolyn Compton, Helen Moore, Lokesh Agrawal, Hartmut Juhl and Kerstin A. David
    Citation: Journal of Translational Medicine 2016 14:6
    Content type: Research Published on:

  15. Alliance Against Cancer (ACC) was established in Rome in 2002 as a consortium of six Italian comprehensive cancer centers (Founders). The aims of ACC were to promote a network among Italian oncologic instituti...

    Authors: Paolo De Paoli, Gennaro Ciliberto, Manlio Ferrarini, PierGiuseppe Pelicci, Paolo Dellabona, Francesco De Lorenzo, Alberto Mantovani, Pellegrino Musto, Giuseppe Opocher, Piero Picci, Walter Ricciardi and Ruggero De Maria
    Citation: Journal of Translational Medicine 2015 13:360
    Content type: Commentary Published on:

  16. Renal fibrosis is a main cause of end-stage renal disease. Clinically, there is no beneficial treatment that can effectively reverse the progressive loss of renal function. We recently synthesized a novel prot...

    Authors: Cheng Yang, Ye Cao, Yi Zhang, Long Li, Ming Xu, Yaqiu Long, Ruiming Rong and Tongyu Zhu
    Citation: Journal of Translational Medicine 2015 13:355
    Content type: Research Published on:

  17. Atrial fibrillation is a progressive arrhythmia, the exact mechanism underlying the progressive nature of recurrent AF episodes is still unknown. Recently, it was found that key players of the protein quality ...

    Authors: Eva A. H. Lanters, Denise M. S. van Marion, Charles Kik, Herman Steen, Ad J. J. C. Bogers, Maurits A. Allessie, Bianca J. J. M. Brundel and Natasja M. S. de Groot
    Citation: Journal of Translational Medicine 2015 13:347
    Content type: Protocol Published on:

  18. Opinion-based commentary about the complex reality of being a clinician-scientist in today’s modern biomedical environment. The essay uses the beautiful, but old, poem “If” from Rudyard Kipling to draw a paral...

    Authors: Pierre R. Smeesters
    Citation: Journal of Translational Medicine 2015 13:345
    Content type: Editorial Published on:

  19. Many kidneys are rejected for transplantation due to inadequate in situ perfusion during organ retrieval because of the risk of additional ischaemic injury and microvasculature thrombosis. This study describes...

    Authors: Sarah A. Hosgood, A. D. Barlow, J. Dormer and M. L. Nicholson
    Citation: Journal of Translational Medicine 2015 13:329
    Content type: Research Published on:

  20. There is growing evidence that variations in the gene encoding inosine triphosphate pyrophosphohydrolase (ITPase), known as inosine triphosphatase (ITPA), are related to hemolytic anemia, which is frequently obse...

    Authors: Daniel Pineda-Tenor, Mónica García-Álvarez, María A. Jiménez-Sousa, Sonia Vázquez-Morón and Salvador Resino
    Citation: Journal of Translational Medicine 2015 13:320
    Content type: Research Published on:

  21. The strategy of using fecal microbiota transplantation (FMT) for refractory ulcerative colitis (UC) remains unclear if single FMT failed to induce remission. This study aimed to evaluate the efficacy and safet...

    Authors: Bota Cui, Pan Li, Lijuan Xu, Youquan Zhao, Huiquan Wang, Zhaoyuan Peng, Hai’e Xu, Jie Xiang, Zhi He, Ting Zhang, Yongzhan Nie, Kaichun Wu, Daiming Fan, Guozhong Ji and Faming Zhang
    Citation: Journal of Translational Medicine 2015 13:298
    Content type: Research Published on:

  22. NK cells can destroy tumor cells without prior sensitization or immunization. Tumors often lose expression of MHC molecules and/or antigens. However, NK cells can lyse tumor cells in a non-MHC-restricted manne...

    Authors: Naoyuki Sakamoto, Takeshi Ishikawa, Satoshi Kokura, Tetsuya Okayama, Kaname Oka, Mitsuko Ideno, Fumiyo Sakai, Akiko Kato, Masashige Tanabe, Tatsuji Enoki, Junichi Mineno, Yuji Naito, Yoshito Itoh and Toshikazu Yoshikawa
    Citation: Journal of Translational Medicine 2015 13:277
    Content type: Research Published on:

  23. The latest high-throughput sequencing technologies show that there are more than 1000 types of microbiota in the human gut. These microbes are not only important to maintain human health, but also closely rela...

    Authors: Weilin Wang, Shaoyan Xu, Zhigang Ren, Jianwen Jiang and Shusen Zheng
    Citation: Journal of Translational Medicine 2015 13:275
    Content type: Review Published on:

  24. In human medicine clinical trials are legally required for drug development and approval. In contrast, clinical trials in small animal cancer patients are less common and legally perceived as animal experiment...

    Authors: Irene Fürdös, Judit Fazekas, Josef Singer and Erika Jensen-Jarolim
    Citation: Journal of Translational Medicine 2015 13:265
    Content type: Review Published on:

  25. The American College of Obstetrics and Gynecology (ACOG) and Maternal Fetal Medicine (MFM) Societies recommended that abnormal cfDNA fetal results should be confirmed by amniocentesis and karyotyping. Our results...

    Authors: Roger V Lebo, Robert W Novak, Katherine Wolfe, Melonie Michelson, Haynes Robinson and Melissa S Mancuso
    Citation: Journal of Translational Medicine 2015 13:260
    Content type: Research Published on:

  26. In clinic settings, rel apsed leukemic patients are found to be more fragile to chemotherapy due to delayed or incomplete hematopoietic recovery, and hematopoiesis of these patients seem to be impaired.

    Authors: Chuanhe Jiang, Xiaoxia Hu, Libing Wang, Hui Cheng, Yan Lin, Yakun Pang, Weiping Yuan, Tao Cheng and Jianmin Wang
    Citation: Journal of Translational Medicine 2015 13:234
    Content type: Research Published on:

  27. The failure in standard triple therapy has recently increased to high levels in China, primarily because of insufficient patient compliance, antimicrobial resistance, and high costs. Effective prevention and e...

    Authors: Dailun Hu, Feng Zhang, Jikun Zhou, Baohong Xu, Hongying Zhang, Huiqin Qiang, Shuguang Ren, Baoen Shan, Changfu Yin, Zhitao Zhang, Xian Wang, Chuan Zhao and Zhongli Shi
    Citation: Journal of Translational Medicine 2015 13:205
    Content type: Research Published on:

  28. Corticosteroids are preferred to treat patients with active IgA nephropathy (IgAN), and beneficial effects from the short-term use of corticosteroids have been confirmed. However, a large number of patients wi...

    Authors: Yanhong Yuan, Qin Wang, Zhaohui Ni, Xiajing Che, Liou Cao, Xinghua Shao, Minfang Zhang, Yuanyuan Xie, Chaojun Qi, Wenyan Zhou, Lei Tian and Shan Mou
    Citation: Journal of Translational Medicine 2015 13:186
    Content type: Research Published on:

  29. Influenza H5N1 is one subtype of the influenza A virus which can infect human bodies and lead to death. Timely diagnosis before its breakout is vital to the human health. The current clinical biochemical diagn...

    Authors: Min Zhu, Xue Gong, Yonghong Hu, Weijun Ou and Yakun Wan
    Citation: Journal of Translational Medicine 2014 12:352
    Content type: Research Published on:

  30. Although the efficacy of zoledronic acid in postmenopausal women with breast cancer has been suggested, the underlying mechanism has not been fully clarified. Therefore, which patients may benefit from zoledro...

    Authors: Eriko Sumi, Tomoharu Sugie, Kenichi Yoshimura, Harue Tada, Takafumi Ikeda, Eiji Suzuki, Yoshimasa Tanaka, Satoshi Teramukai, Akira Shimizu, Masakazu Toi and Nagahiro Minato
    Citation: Journal of Translational Medicine 2014 12:310
    Content type: Protocol Published on:

  31. Hereditary hearing loss is genetically heterogeneous, and hundreds of mutations in than 60 genes are involved in this disease. Therefore, it is difficult to identify the causative gene mutations involved. In t...

    Authors: Qinjun Wei, Hongmei Zhu, Xuli Qian, Zhibin Chen, Jun Yao, Yajie Lu, Xin Cao and Guangqian Xing
    Citation: Journal of Translational Medicine 2014 12:311
    Content type: Research Published on:

  32. Tumor cells killed by radiation therapy (RT) are a potentially good source of antigens for dendritic cell (DC) uptake and presentation to T-cells. RT upregulates cell death receptors such as Fas/CD95 and MHC-I...

    Authors: Laura Ridolfi, Francesco de Rosa, Ruggero Ridolfi, Giorgia Gentili, Linda Valmorri, Emanuela Scarpi, Elisabetta Parisi, Antonino Romeo and Massimo Guidoboni
    Citation: Journal of Translational Medicine 2014 12:262
    Content type: Protocol Published on:

  33. Umbilical cord mesenchymal stem cells (UCMSCs) have a considerable advantage and potential in treating for central nervous system diseases and have become a novel alternative treatment for spinal cord injury. ...

    Authors: Hongbin Cheng, Xuebin Liu, Rongrong Hua, Guanghui Dai, Xiaodong Wang, Jianhua Gao and Yihua An
    Citation: Journal of Translational Medicine 2014 12:253
    Content type: Research Published on:

  34. Accurate estimation of a burned area is crucial to decisions about fluid resuscitation, surgical options, nutritional support, and prognosis. Widely used clinical methods to estimate a burn area are two-dimens...

    Authors: Wen-bo Sheng, Ding Zeng, Yan Wan, Li Yao, Hong-tai Tang and Zhao-fan Xia
    Citation: Journal of Translational Medicine 2014 12:242
    Content type: Research Published on:

  35. Human placenta releases specific nanovesicles (i.e. exosomes) into the maternal circulation during pregnancy, however, the presence of placenta-derived exosomes in maternal blood during early pregnancy remains to...

    Authors: Suchismita Sarker, Katherin Scholz-Romero, Alejandra Perez, Sebastian E Illanes, Murray D Mitchell, Gregory E Rice and Carlos Salomon
    Citation: Journal of Translational Medicine 2014 12:204
    Content type: Research Published on:

  36. Vaccination with dendritic cells (DC) loaded with tumor antigens elicits tumor-specific immune responses capable of killing cancer cells without inducing meaningful side-effects. Patients with advanced melanom...

    Authors: Francesco de Rosa, Laura Ridolfi, Ruggero Ridolfi, Giorgia Gentili, Linda Valmorri, Oriana Nanni, Massimiliano Petrini, Laura Fiammenghi, Anna Maria Granato, Valentina Ancarani, Elena Pancisi, Valentina Soldati, Serena Cassan, Angela Riccobon, Elisabetta Parisi, Antonino Romeo…
    Citation: Journal of Translational Medicine 2014 12:209
    Content type: Protocol Published on:

  37. Rapidly determining the complex genetic basis of Hypertrophic cardiomyopathy (HCM) is vital to better understanding and optimally managing this common polygenetic cardiovascular disease.

    Authors: Zongzhe Li, Jin Huang, Jinzhao Zhao, Chen Chen, Hong Wang, Hu Ding, Dao Wu Wang and Dao Wen Wang
    Citation: Journal of Translational Medicine 2014 12:173
    Content type: Methodology Published on:

  38. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multi-system illness characterized, in part, by increased fatigue following minimal exertion, cognitive impairment, poor recovery to physical an...

    Authors: Betsy A Keller, John Luke Pryor and Ludovic Giloteaux
    Citation: Journal of Translational Medicine 2014 12:104
    Content type: Research Published on:

  39. CD40-CD40 ligand (CD40L) interaction is considered to contribute to the promotion of prothrombotic responses and production of angiogenesis-associated factor in addition to adaptive immune responses. Recently,...

    Authors: Hye Won Chung and Jong-Baeck Lim
    Citation: Journal of Translational Medicine 2014 12:102
    Content type: Research Published on:

  40. Immunotherapy offers a promising novel approach for the treatment of cancer and both adoptive T-cell transfer and immune modulation lead to regression of advanced melanoma. However, the potential synergy betwe...

    Authors: Emanuela Romano, Olivier Michielin, Verena Voelter, Julien Laurent, Hélène Bichat, Athina Stravodimou, Pedro Romero, Daniel E Speiser, Frédéric Triebel, Serge Leyvraz and Alexandre Harari
    Citation: Journal of Translational Medicine 2014 12:97
    Content type: Research Published on:

  41. Chemoradiation therapy (CRT) has been widely used for unresectable esophageal squamous cell carcinoma (ESCC) patients. However, many patients develop local recurrence after CRT. In this study, we hypothesized ...

    Authors: Hisae Iinuma, Ryoji Fukushima, Tsuyoshi Inaba, Junko Tamura, Taisuke Inoue, Etsushi Ogawa, Masahiro Horikawa, Yoshibumi Ikeda, Noriyuki Matsutani, Kazuyoshi Takeda, Koji Yoshida, Takuya Tsunoda, Tadashi Ikeda, Yusuke Nakamura and Kota Okinaga
    Citation: Journal of Translational Medicine 2014 12:84
    Content type: Research Published on:

  42. Red cell distribution width (RDW) has been recognized as a novel marker for several cardiovascular diseases. The aim of this study was to evaluate the association between RDW levels and the presence of isolate...

    Authors: Xiao-Lin Li, Li-Feng Hong, Yan-Jun Jia, Shao-Ping Nie, Yuan-Lin Guo, Rui-Xia Xu, Cheng-Gang Zhu, Li-Xin Jiang and Jian-Jun Li
    Citation: Journal of Translational Medicine 2014 12:62
    Content type: Research Published on:

  43. Although patients with liver failure exhibit a generalized inflammatory-imbalance status, substantial evidence indicates that this immunosuppressive or anti-inflammatory state may be deleterious. Increased exp...

    Authors: Min Zhang, Yinong Ye, Fenglan Wang, Jianyun Zhu, Qiyi Zhao, Yubao Zheng, Yurong Gu, Chan Xie, Zhanlian Huang, Qiang Tai, Yutian Chong and Zhiliang Gao
    Citation: Journal of Translational Medicine 2014 12:60
    Content type: Research Published on:

  44. The primary aim of this pilot study was to determine the feasibility and safety of an adoptive transfer and in vivo expansion of human haploidentical γδ T lymphocytes.

    Authors: Martin Wilhelm, Manfred Smetak, Kerstin Schaefer-Eckart, Brigitte Kimmel, Josef Birkmann, Hermann Einsele and Volker Kunzmann
    Citation: Journal of Translational Medicine 2014 12:45
    Content type: Research Published on:

  45. Parenterally administered ascorbic acid modulates sepsis-induced inflammation and coagulation in experimental animal models. The objective of this randomized, double-blind, placebo-controlled, phase I trial wa...

    Authors: Alpha A Fowler III, Aamer A Syed, Shelley Knowlson, Robin Sculthorpe, Don Farthing, Christine DeWilde, Christine A Farthing, Terri L Larus, Erika Martin, Donald F Brophy, Seema Gupta, Bernard J Fisher and Ramesh Natarajan
    Citation: Journal of Translational Medicine 2014 12:32
    Content type: Research Published on:

  46. PAD is a disabling, chronic condition of the lower extremities that affects approximately 8 million people in the United States. The purpose of this study was to determine whether an innovative home-based walk...

    Authors: W Jack Rejeski, Bonnie Spring, Kathryn Domanchuk, Huimin Tao, Lu Tian, Lihui Zhao and Mary M McDermott
    Citation: Journal of Translational Medicine 2014 12:29
    Content type: Research Published on:

  47. Progressive Supranuclear Palsy (PSP) is a sporadic and progressive neurodegenerative disease which belongs to the family of tauopathies and involves both cortical and subcortical structures. No effective thera...

    Authors: Rosaria Giordano, Margherita Canesi, Maurizio Isalberti, Ioannis Ugo Isaias, Tiziana Montemurro, Mariele Viganò, Elisa Montelatici, Valentina Boldrin, Riccardo Benti, Agostino Cortelezzi, Nicola Fracchiolla, Lorenza Lazzari and Gianni Pezzoli
    Citation: Journal of Translational Medicine 2014 12:14
    Content type: Protocol Published on:

  48. This study compared the clinical efficacies, advantages and disadvantages of two transplantation approaches for treating spinal cord injury: open surgical exploration combined with local stem cell transplantat...

    Authors: Guanghui Dai, Xuebin Liu, Zan Zhang, Xiaodong Wang, Min Li, Hongbin Cheng, Rongrong Hua, Jing Shi, Renzhi Wang, Chuan Qin, Jianhua Gao and Yihua An
    Citation: Journal of Translational Medicine 2013 11:315
    Content type: Research Published on:

  49. The goal of this study was to test the hypothesis that autoantibodies against M2-muscarinic acetylcholine receptor (M2-AAB) are associated with severe preeclampsia and increased risk of adverse perinatal outcomes...

    Authors: Yanfang Li, Guiling Ma, Zhiyong Zhang, Yin Yue, Yuting Yuan, Yidan Wang, Guobin Miao and Lin Zhang
    Citation: Journal of Translational Medicine 2013 11:285
    Content type: Research Published on:

  50. Acute myeloid leukemia (AML) and other aggressive refractory hematological malignancies unresponsive to upfront therapy remain difficult conditions to treat. Often, the focus of therapy is centered on achievin...

    Authors: John L Reagan, Loren D Fast, Howard Safran, Martha Nevola, Eric S Winer, Jorge J Castillo, James N Butera, Matthew I Quesenberry, Carolyn T Young and Peter J Quesenberry
    Citation: Journal of Translational Medicine 2013 11:150
    Content type: Protocol Published on:
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