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Clinical translation

Section edited by Lana Kandalaft

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

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  1. Content type: Research

    CD40-CD40 ligand (CD40L) interaction is considered to contribute to the promotion of prothrombotic responses and production of angiogenesis-associated factor in addition to adaptive immune responses. Recently,...

    Authors: Hye Won Chung and Jong-Baeck Lim

    Citation: Journal of Translational Medicine 2014 12:102

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  2. Content type: Research

    Immunotherapy offers a promising novel approach for the treatment of cancer and both adoptive T-cell transfer and immune modulation lead to regression of advanced melanoma. However, the potential synergy betwe...

    Authors: Emanuela Romano, Olivier Michielin, Verena Voelter, Julien Laurent, Hélène Bichat, Athina Stravodimou, Pedro Romero, Daniel E Speiser, Frédéric Triebel, Serge Leyvraz and Alexandre Harari

    Citation: Journal of Translational Medicine 2014 12:97

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  3. Content type: Research

    Chemoradiation therapy (CRT) has been widely used for unresectable esophageal squamous cell carcinoma (ESCC) patients. However, many patients develop local recurrence after CRT. In this study, we hypothesized ...

    Authors: Hisae Iinuma, Ryoji Fukushima, Tsuyoshi Inaba, Junko Tamura, Taisuke Inoue, Etsushi Ogawa, Masahiro Horikawa, Yoshibumi Ikeda, Noriyuki Matsutani, Kazuyoshi Takeda, Koji Yoshida, Takuya Tsunoda, Tadashi Ikeda, Yusuke Nakamura and Kota Okinaga

    Citation: Journal of Translational Medicine 2014 12:84

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  4. Content type: Research

    Red cell distribution width (RDW) has been recognized as a novel marker for several cardiovascular diseases. The aim of this study was to evaluate the association between RDW levels and the presence of isolate...

    Authors: Xiao-Lin Li, Li-Feng Hong, Yan-Jun Jia, Shao-Ping Nie, Yuan-Lin Guo, Rui-Xia Xu, Cheng-Gang Zhu, Li-Xin Jiang and Jian-Jun Li

    Citation: Journal of Translational Medicine 2014 12:62

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  5. Content type: Research

    Although patients with liver failure exhibit a generalized inflammatory-imbalance status, substantial evidence indicates that this immunosuppressive or anti-inflammatory state may be deleterious. Increased exp...

    Authors: Min Zhang, Yinong Ye, Fenglan Wang, Jianyun Zhu, Qiyi Zhao, Yubao Zheng, Yurong Gu, Chan Xie, Zhanlian Huang, Qiang Tai, Yutian Chong and Zhiliang Gao

    Citation: Journal of Translational Medicine 2014 12:60

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  6. Content type: Research

    The primary aim of this pilot study was to determine the feasibility and safety of an adoptive transfer and in vivo expansion of human haploidentical γδ T lymphocytes.

    Authors: Martin Wilhelm, Manfred Smetak, Kerstin Schaefer-Eckart, Brigitte Kimmel, Josef Birkmann, Hermann Einsele and Volker Kunzmann

    Citation: Journal of Translational Medicine 2014 12:45

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  7. Content type: Research

    Parenterally administered ascorbic acid modulates sepsis-induced inflammation and coagulation in experimental animal models. The objective of this randomized, double-blind, placebo-controlled, phase I trial wa...

    Authors: Alpha A Fowler III, Aamer A Syed, Shelley Knowlson, Robin Sculthorpe, Don Farthing, Christine DeWilde, Christine A Farthing, Terri L Larus, Erika Martin, Donald F Brophy, Seema Gupta, Bernard J Fisher and Ramesh Natarajan

    Citation: Journal of Translational Medicine 2014 12:32

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  8. Content type: Research

    PAD is a disabling, chronic condition of the lower extremities that affects approximately 8 million people in the United States. The purpose of this study was to determine whether an innovative home-based walk...

    Authors: W Jack Rejeski, Bonnie Spring, Kathryn Domanchuk, Huimin Tao, Lu Tian, Lihui Zhao and Mary M McDermott

    Citation: Journal of Translational Medicine 2014 12:29

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  9. Content type: Protocol

    Progressive Supranuclear Palsy (PSP) is a sporadic and progressive neurodegenerative disease which belongs to the family of tauopathies and involves both cortical and subcortical structures. No effective thera...

    Authors: Rosaria Giordano, Margherita Canesi, Maurizio Isalberti, Ioannis Ugo Isaias, Tiziana Montemurro, Mariele Viganò, Elisa Montelatici, Valentina Boldrin, Riccardo Benti, Agostino Cortelezzi, Nicola Fracchiolla, Lorenza Lazzari and Gianni Pezzoli

    Citation: Journal of Translational Medicine 2014 12:14

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  10. Content type: Research

    This study compared the clinical efficacies, advantages and disadvantages of two transplantation approaches for treating spinal cord injury: open surgical exploration combined with local stem cell transplantat...

    Authors: Guanghui Dai, Xuebin Liu, Zan Zhang, Xiaodong Wang, Min Li, Hongbin Cheng, Rongrong Hua, Jing Shi, Renzhi Wang, Chuan Qin, Jianhua Gao and Yihua An

    Citation: Journal of Translational Medicine 2013 11:315

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  11. Content type: Research

    The goal of this study was to test the hypothesis that autoantibodies against M2-muscarinic acetylcholine receptor (M2-AAB) are associated with severe preeclampsia and increased risk of adverse perinatal outcomes...

    Authors: Yanfang Li, Guiling Ma, Zhiyong Zhang, Yin Yue, Yuting Yuan, Yidan Wang, Guobin Miao and Lin Zhang

    Citation: Journal of Translational Medicine 2013 11:285

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  12. Content type: Protocol

    Acute myeloid leukemia (AML) and other aggressive refractory hematological malignancies unresponsive to upfront therapy remain difficult conditions to treat. Often, the focus of therapy is centered on achievin...

    Authors: John L Reagan, Loren D Fast, Howard Safran, Martha Nevola, Eric S Winer, Jorge J Castillo, James N Butera, Matthew I Quesenberry, Carolyn T Young and Peter J Quesenberry

    Citation: Journal of Translational Medicine 2013 11:150

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  13. Content type: Commentary

    Ovarian cancer, like most solid tumors, is in dire need of effective therapies. The significance of this trial lies in its promise to spearhead the development of combination immunotherapy and to introduce nov...

    Authors: Lana E Kandalaft, Cheryl L Chiang, Janos Tanyi, Greg Motz, Klara Balint, Rosemarie Mick and George Coukos

    Citation: Journal of Translational Medicine 2013 11:149

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  14. Content type: Research

    Inducing donor-specific tolerance in renal transplant patients could potentially prevent allograft rejection and calcineurin inhibitor nephrotoxicity. Combined kidney and hematopoietic stem cell transplant fro...

    Authors: Duojiao Wu, Guisheng Qi, Xuanchuan Wang, Ming Xu, Ruiming Rong, Xiangdong Wang and Tongyu Zhu

    Citation: Journal of Translational Medicine 2012 10:182

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  15. Content type: Research

    Chronic inflammation may contribute to insulin resistance (IR), metabolic syndrome and atherosclerosis although evidence of causality is lacking in humans. We hypothesized that very low-dose experimental endot...

    Authors: Nehal N Mehta, Sean P Heffron, Parth N Patel, Jane Ferguson, Rachana D Shah, Christine C Hinkle, Parasuram Krishnamoorthy, Rhia Shah, Jennifer Tabita-Martinez, Karen Terembula, Stephen R Master, Michael R Rickels and Muredach P Reilly

    Citation: Journal of Translational Medicine 2012 10:124

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  16. Content type: Research

    The potent ribonucleotide reductase (RNR) inhibitor 3-aminopyridine-2-carboxyaldehyde-thiosemicarbazone (3-AP) was tested as a chemosensitizer for restored cisplatin-mediated cytotoxicity in platinum-resistant...

    Authors: Charles Kunos, Tomas Radivoyevitch, Fadi W Abdul-Karim, James Fanning, Ovadia Abulafia, Albert J Bonebrake and Lydia Usha

    Citation: Journal of Translational Medicine 2012 10:79

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  17. Content type: Research

    Nearly one-third of the United States adult population suffers from hypertension. Hydrochlorothiazide (HCTZ), one of the most commonly used medications to treat hypertension, has variable efficacy. The renal e...

    Authors: Julio D Duarte, Issam Zineh, Ben Burkley, Yan Gong, Taimour Y Langaee, Stephen T Turner, Arlene B Chapman, Eric Boerwinkle, John G Gums, Rhonda M Cooper-DeHoff, Amber L Beitelshees, Kent R Bailey, Roger B Fillingim, Bruce C Kone and Julie A Johnson

    Citation: Journal of Translational Medicine 2012 10:56

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  18. Content type: Research

    To determine whether office, home, ambulatory daytime and nighttime blood pressure (BP) responses to antihypertensive drug therapy measure the same signal and which method provides greatest power to identify g...

    Authors: Stephen T Turner, Gary L Schwartz, Arlene B Chapman, Amber L Beitelshees, John G Gums, Rhonda M Cooper-DeHoff, Eric Boerwinkle, Julie A Johnson and Kent R Bailey

    Citation: Journal of Translational Medicine 2012 10:47

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  19. Content type: Research

    Concomitant with the development of in vitro diagnostic multivariate index assays (IVDMIAs) to improve the diagnostic efficiency of ovarian cancer detection is the need to identify appropriate biostatistical appr...

    Authors: Dominic J Autelitano, Linda Raineri, Kate Knight, Kelly Bannister and Gregory E Rice

    Citation: Journal of Translational Medicine 2012 10:45

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  20. Content type: Research

    Programmed cell death 6 (PDCD6) beside its known proapoptotic functions may be a player in survival pathways in cancer. The purpose of this study is to further explore the roles of PDCD6 in epithelial ovarian ...

    Authors: Dan Su, Haiyan Xu, Jianguo Feng, Yun Gao, Linhui Gu, Lisha Ying, Dionyssios Katsaros, Herbert Yu, Shenhua Xu and Ming Qi

    Citation: Journal of Translational Medicine 2012 10:31

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  21. Content type: Research

    Prognostic index for survival estimation by clinical-demographic variables were previously proposed in chronic lymphocytic leukemia (CLL) patients. Our objective was to test in a large retrospective cohort of ...

    Authors: Pietro Bulian, Davide Rossi, Francesco Forconi, Giovanni Del Poeta, Francesco Bertoni, Emanuele Zucca, Marco Montillo, Gabriele Pozzato, Giovanni D'Arena, Dimitar G Efremov, Roberto Marasca, Francesco Lauria, Gianluca Gaidano, Valter Gattei and Luca Laurenti

    Citation: Journal of Translational Medicine 2012 10:18

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  22. Content type: Research

    Results from large epidemiologic studies on the association between vitamin D and gastric cancer are controversial. Vitamin D significantly promotes apoptosis in the undifferentiated gastric cancer cell, but t...

    Authors: Chao Ren, Miao-zhen Qiu, De-shen Wang, Hui-yan Luo, Dong-sheng Zhang, Zhi-qiang Wang, Feng-hua Wang, Yu-hong Li, Zhi-wei Zhou and Rui-hua Xu

    Citation: Journal of Translational Medicine 2012 10:16

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  23. Content type: Research

    Overcoming the notorious apoptotic resistance of melanoma cells remains a therapeutic challenge given dismal survival of patients with metastatic melanoma. However, recent clinical trials using a BRAF inhibito...

    Authors: Jianzhong Qin, Hong Xin and Brian J Nickoloff

    Citation: Journal of Translational Medicine 2012 10:15

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