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Cell, tissue and gene therapy

Section edited by David Stroncek

This section aims to improve communication between basic and clinical research related to cell, tissue and gene therapies. Effective clinical therapies require efficient translation of research between the bench and bedside to allow the discovery, development, scale up, and production of cells, tissues and vectors. These therapies are being used to treat patients with a range of diseases including cancer, cardiovascular diseases, autoimmune disorders.

Studies considered for publication include those regarding the nature of cells, tissues and vectors used in clinical therapies; methods to collect, isolate and modify cells; and novel reagents, equipment, and instruments used in production. The section also welcomes research into the application of clinical therapies; factors that effect the safety and efficacy; in particular the potency, stability and purity of cells or tissue; and issues related to the safety of cell and tissue donors.

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  1. Content type: Research

    Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion injury in animal models. However, as hESC-MSCs are not...

    Authors: Tian Sheng Chen, Fatih Arslan, Yijun Yin, Soon Sim Tan, Ruenn Chai Lai, Andre Boon Hwa Choo, Jayanthi Padmanabhan, Chuen Neng Lee, Dominique PV de Kleijn and Sai Kiang Lim

    Citation: Journal of Translational Medicine 2011 9:47

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  2. Content type: Methodology

    siRNA technology is a promising tool for gene therapy of vascular disease. Due to the multitude of reagents and cell types, RNAi experiment optimization can be time-consuming. In this study adherent cell cytom...

    Authors: Christoph S Nabzdyk, Maggie Chun, Leena Pradhan and Frank W LoGerfo

    Citation: Journal of Translational Medicine 2011 9:48

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  3. Content type: Research

    Polyethyleneimine (PEI), which can interact with negatively charged DNA through electrostatic interaction to form nanocomplexes, has been widely attempted to use as a gene delivery system. However, PEI has som...

    Authors: Zhizhong Xu, Guobo Shen, Xiangying Xia, Xinyu Zhao, Peng Zhang, Huanhuan Wu, Qingfa Guo, Zhiyong Qian, Yuquan Wei and Shufang Liang

    Citation: Journal of Translational Medicine 2011 9:46

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  4. Content type: Research

    The aim of the present study was to analyze the expression of Cyclin-dependent kinase 4 (CDK4) in lung cancer and its correlation with clinicopathologic features. Furthermore, the involvement of CDK4-mediated cel...

    Authors: Aibing Wu, Bin Wu, Jinsong Guo, Weiren Luo, Dong Wu, Huiling Yang, Yan Zhen, Xiaoli Yu, Hao Wang, Ying Zhou, Zhen Liu, Weiyi Fang and Zhixiong Yang

    Citation: Journal of Translational Medicine 2011 9:38

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  5. Content type: Research

    Gene therapy is a promising therapeutic approach for cancer. Targeted expression of desired therapeutic proteins within the tumor is the best approach to reduce toxicity and improve survival. This study is to ...

    Authors: Yu Xu, Jinxuan Hou, Zhengchun Liu, Haijun Yu, Wenjie Sun, Jie Xiong, Zhengkai Liao, Fuxiang Zhou, Conghua Xie and Yunfeng Zhou

    Citation: Journal of Translational Medicine 2011 9:39

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  6. Content type: Review

    Stem cell therapy holds the promise to treat degenerative diseases, cancer and repair of damaged tissues for which there are currently no or limited therapeutic options. The potential of stem cell therapies ha...

    Authors: Carla A Herberts, Marcel SG Kwa and Harm PH Hermsen

    Citation: Journal of Translational Medicine 2011 9:29

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  7. Content type: Erratum

    After publication of our article [1], we realized the need for posting a correction note in order to prevent i) overinterpretation of some results by the readers and ii) concerns about potentially unintended misg...

    Authors: Michaela Muth, Kais Hussein, Christoph Jacobi, Hans Kreipe and Oliver Bock

    Citation: Journal of Translational Medicine 2011 9:24

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    The original article was published in Journal of Translational Medicine 2010 8:33

  8. Content type: Commentary

    We challenge the hypothesis of enhanced myocardial reperfusion after implanting a left ventricular assist device together with bone marrow mononuclear stem cells in patients with end-stage ischemic cardiomyopa...

    Authors: Kyriakos Anastasiadis, Polychronis Antonitsis, Helena Argiriadou, Georgios Koliakos, Argyrios Doumas, Andre Khayat, Christos Papakonstantinou and Stephen Westaby

    Citation: Journal of Translational Medicine 2011 9:12

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  9. Content type: Research

    We investigated whether myocardium-derived conditioned medium (MDCM) is effective in preserving left ventricular (LV) function in a rat acute myocardial infarction (AMI) model.

    Authors: Steve Leu, Ying-Hsien Kao, Cheuk-Kwan Sun, Yu-Chun Lin, Tzu-Hsien Tsai, Li-Teh Chang, Sarah Chua, Kuo-Ho Yeh, Chiung-Jen Wu, Morgan Fu and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2011 9:11

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  10. Content type: Research

    Mesenchymal stem cells derived from adipose tissue (ADSC) are multipotent stem cells, originated from the vascular-stromal compartment of fat tissue. ADSC are used as an alternative cell source for many differ...

    Authors: Anastasia Efimenko, Ekaterina Starostina, Natalia Kalinina and Alexandra Stolzing

    Citation: Journal of Translational Medicine 2011 9:10

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  11. Content type: Research

    Adenoid cystic carcinoma is one of the most common types of salivary gland cancers. The poor long-term prognosis for patients with adenoid cystic carcinoma is mainly due to local recurrence and distant metasta...

    Authors: Qin Xu, Xiuming Liu, Wantao Chen and Zhiyuan Zhang

    Citation: Journal of Translational Medicine 2010 8:136

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  12. Content type: Research

    Apoptosis is an early event involved in cardiomyopathy associated with diabetes mellitus. Toll-like receptor (TLR) signaling triggers cell apoptosis through multiple mechanisms. Up-regulation of TLR4 expressio...

    Authors: Yuwei Zhang, Tianqing Peng, Huaqing Zhu, Xiufen Zheng, Xusheng Zhang, Nan Jiang, Xiaoshu Cheng, Xiaoyan Lai, Aminah Shunnar, Manpreet Singh, Neil Riordan, Vladimir Bogin, Nanwei Tong and Wei-Ping Min

    Citation: Journal of Translational Medicine 2010 8:133

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  13. Content type: Research

    Growth hormone (GH) is an essential regulator of intrahepatic lipid metabolism by activating multiple complex hepatic signaling cascades. Here, we examined whether chronic exogenous GH administration (via gene...

    Authors: Ying Qin and Ya-ping Tian

    Citation: Journal of Translational Medicine 2010 8:120

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  14. Content type: Research

    Culturing otospheres from dissociated organ of Corti is an appropriate starting point aiming at the development of cell therapy for hair cell loss. Although guinea pigs have been widely used as an excellent ex...

    Authors: Jeanne Oiticica, Luiz Carlos M Barboza-Junior, Ana Carla Batissoco, Karina Lezirovitz, Regina C Mingroni-Netto, Luciana A Haddad and Ricardo F Bento

    Citation: Journal of Translational Medicine 2010 8:119

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  15. Content type: Commentary

    Recent years have seen a growing interest in insulin-like growth factor 1 receptor (IGF1R) in medical oncology. Interesting data have been reported also on IGF1r in gastrointestinal stromal tumors (GISTs) espe...

    Authors: Maria A Pantaleo, Annalisa Astolfi, Margherita Nannini and Guido Biasco

    Citation: Journal of Translational Medicine 2010 8:117

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  16. Content type: Research

    The ability to expand virus- or tumor-specific T cells without damaging their functional capabilities is critical for success adoptive transfer immunotherapy of patients with opportunistic infection or tumor. ...

    Authors: Yixin Li and Roger J Kurlander

    Citation: Journal of Translational Medicine 2010 8:104

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  17. Content type: Research

    We investigated whether early combined autologous adipose-derived mesenchymal stem cell (ADMSC) and sildenafil therapy offers an additive benefit in preserving heart function in rat dilated cardiomyopathy (DCM).

    Authors: Yu-Chun Lin, Steve Leu, Cheuk-Kwan Sun, Chia-Hung Yen, Ying-Hsien Kao, Li-Teh Chang, Tzu-Hsien Tsai, Sarah Chua, Morgan Fu, Sheung-Fat Ko, Chiung-Jen Wu, Fan-Yen Lee and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2010 8:88

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  18. Content type: Research

    The current paradigm for cord blood transplantation is that HLA matching and immune suppression are strictly required to prevent graft versus host disease (GVHD). Immunological arguments and historical example...

    Authors: Wan-Zhang Yang, Yun Zhang, Fang Wu, Wei-Ping Min, Boris Minev, Min Zhang, Xiao-Ling Luo, Famela Ramos, Thomas E Ichim, Neil H Riordan and Xiang Hu

    Citation: Journal of Translational Medicine 2010 8:75

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  19. Content type: Research

    The therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on brain infarction area (BIA) and neurological status in a rat model of acute ischemic stroke (IS) was investigated.

    Authors: Steve Leu, Yu-Chun Lin, Chun-Man Yuen, Chia-Hung Yen, Ying-Hsien Kao, Cheuk-Kwan Sun and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2010 8:63

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  20. Content type: Research

    This manuscript reports the production and preclinical studies to examine the tolerance and efficacy of an autologous cellular gel-matrix integrated implant system (IIS) aimed to treat full-thickness skin lesi...

    Authors: Caroline R Weinstein-Oppenheimer, Alexis R Aceituno, Donald I Brown, Cristian Acevedo, Ricardo Ceriani, Miguel A Fuentes, Fernando Albornoz, Carlos F Henríquez-Roldán, Patricio Morales, Claudio Maclean, Sergio M Tapia and Manuel E Young

    Citation: Journal of Translational Medicine 2010 8:59

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  21. Content type: Research

    While adjuvant immunotherapy with Bacille Calmette Guérin (BCG) is effective in non-muscle-invasive bladder cancer (BC), adverse events (AEs) are considerable. Monocyte-derived activated killer cells (MAK) are...

    Authors: Maximilian Burger, Nicolas Thiounn, Stefan Denzinger, Jozsef Kondas, Gerard Benoit, Manuel S Chapado, Fernando J Jimenz-Cruz, Laszlo Kisbenedek, Zoltán Szabo, Domján Zsolt, Marc O Grimm, Imre Romics, Joachim W Thüroff, Tamas Kiss, Bertrand Tombal, Manfred Wirth…

    Citation: Journal of Translational Medicine 2010 8:54

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  22. Content type: Research

    Antigen processing by dendritic cells (DC) exposed to specific stimuli has been well characterized in biological studies. Nonetheless, the question of whether autologous whole tumor lysates (as used in clinica...

    Authors: Laura Fiammenghi, Valentina Ancarani, Tilman Rosales, Jay R Knutson, Massimiliano Petrini, Anna Maria Granato, Elena Pancisi, Laura Ridolfi, Ruggero Ridolfi, Angela Riccobon and Paolo Neyroz

    Citation: Journal of Translational Medicine 2010 8:52

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  23. Content type: Research

    MicroRNAs are highly conserved, noncoding RNAs involved in post-transcriptional gene silencing. They have been shown to participate in a wide range of biological processes, including myogenesis and muscle rege...

    Authors: Stefano Gambardella, Fabrizio Rinaldi, Saverio M Lepore, Antonella Viola, Emanuele Loro, Corrado Angelini, Lodovica Vergani, Giuseppe Novelli and Annalisa Botta

    Citation: Journal of Translational Medicine 2010 8:48

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  24. Content type: Research

    NSC-741909 is a novel anticancer agent that can effectively suppress the growth of several cell lines derived from lung, colon, breast, ovarian, and kidney cancers. We recently showed that NSC-741909-induced a...

    Authors: Xiaoli Wei, Wei Guo, Shuhong Wu, Li Wang, Peng Huang, Jinsong Liu and Bingliang Fang

    Citation: Journal of Translational Medicine 2010 8:37

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  25. Content type: Research

    The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of circulating progenitor cells using G-CSF has resulted in pr...

    Authors: Nina A Mikirova, James A Jackson, Ron Hunninghake, Julian Kenyon, Kyle WH Chan, Cathy A Swindlehurst, Boris Minev, Amit N Patel, Michael P Murphy, Leonard Smith, Famela Ramos, Thomas E Ichim and Neil H Riordan

    Citation: Journal of Translational Medicine 2010 8:34

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  26. Content type: Research

    In damaged organs tissue repair and replacement of cells by connective tissue provokes a response of fibroblasts to cellular stress factors such as hypoxia.

    Authors: Michaela Muth, Katharina Theophile, Kais Hussein, Christoph Jacobi, Hans Kreipe and Oliver Bock

    Citation: Journal of Translational Medicine 2010 8:33

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  27. Content type: Research

    Human stem cells from adult sources have been shown to contribute to the regeneration of muscle, liver, heart, and vasculature. The mechanisms by which this is accomplished are, however, still not well underst...

    Authors: Claus S Sondergaard, David A Hess, Dustin J Maxwell, Carla Weinheimer, Ivana Rosová, Michael H Creer, David Piwnica-Worms, Attila Kovacs, Lene Pedersen and Jan A Nolta

    Citation: Journal of Translational Medicine 2010 8:24

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  28. Content type: Review

    The medical use of low level laser (LLL) irradiation has been occurring for decades, primarily in the area of tissue healing and inflammatory conditions. Despite little mechanistic knowledge, the concept of a ...

    Authors: Feng Lin, Steven F Josephs, Doru T Alexandrescu, Famela Ramos, Vladimir Bogin, Vincent Gammill, Constantin A Dasanu, Rosalia De Necochea-Campion, Amit N Patel, Ewa Carrier and David R Koos

    Citation: Journal of Translational Medicine 2010 8:16

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