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Cancer Metabolism

Section edited by Violena Pietrobon and Mia Stanic

© © natali_mis / stock.adobeTumor cells reprogram nutrient acquisition and metabolic pathways to support abnormal growth and metastasis, a dysfunctional process that is a hallmark of cancer. 

The Cancer Metabolism section will offer a solid framework to promote and disseminate innovative studies examining metabolic reprogramming in cancer cells, including fatty acid, mitochondrial, glycolytic and other metabolic networks.

We are interested in research that investigates and characterizes metabolic alterations in tumors at the molecular level by explaining why this reprogramming occurs and identifying links between such phenomena and cell proliferation and metastasis. We will also consider studies regarding the correlation between genomic mutations, gene expression, epigenetic regulation and metabolic pathway alterations. Of particular interest are investigations focused on translational and clinical aspects and those regarding metabolically targeted pharmacological therapies, with emphasis on patient responsiveness.

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  1. Chemotherapy (CT) is central to the treatment of triple negative breast cancer (TNBC), but drug toxicity and resistance place strong restrictions on treatment regimes. Fasting sensitizes cancer cells to a rang...

    Authors: Ioannis S. Pateras, Chloe Williams, Despoina D. Gianniou, Aggelos T. Margetis, Margaritis Avgeris, Pantelis Rousakis, Aigli-Ioanna Legaki, Peter Mirtschink, Wei Zhang, Konstantina Panoutsopoulou, Anastasios D. Delis, Stamatis N. Pagakis, Wei Tang, Stefan Ambs, Ulrika Warpman Berglund, Thomas Helleday…
    Citation: Journal of Translational Medicine 2023 21:169
  2. Cytoplasmic activation/proliferation-associated protein-1 (Caprin-1) is implicated in cancer cell proliferation and tumorigenesis; however, its role in the development of esophageal carcinoma (ESCA) has not be...

    Authors: Yan Gao, Lingling Yuan, Changbin Ke, Zhijun Pei, Xiaobo Liu, Ruimin Wu, Xueyan Kui and Yanmin Zhang
    Citation: Journal of Translational Medicine 2023 21:159
  3. Although the relationship between type 2 diabetes (T2D) and the increased risk of colorectal carcinogenesis is widely defined in clinical studies, the therapeutic methods and molecular mechanism of T2D-induced...

    Authors: Huiying Li, Chaonan Li, Boyang Zhang and Hongpeng Jiang
    Citation: Journal of Translational Medicine 2023 21:156
  4. Kidney cancer undergoes a dramatic metabolic shift and has demonstrated responsiveness to immunotherapeutic intervention. However, metabolic classification and the associations between metabolic alterations an...

    Authors: Le Li, Zheng Chao, Un Waikeong, Jun Xiao, Yue Ge, Yanan Wang, Zezhong Xiong, Sheng Ma, Zhihua Wang, Zhiquan Hu and Xing Zeng
    Citation: Journal of Translational Medicine 2023 21:146
  5. Osteosarcoma is the most common malignant tumor in bone and its prognosis has reached a plateau in the past few decades. Recently, metabolic reprogramming has attracted increasing attention in the field of can...

    Authors: Gaohong Sheng, Yuan Gao, Qing Ding, Ruizhuo Zhang, Tianqi Wang, Shaoze Jing, Hongqi Zhao, Tian Ma, Hua Wu and Yong Yang
    Citation: Journal of Translational Medicine 2023 21:132
  6. In the past decades studies on anti-tumoral drugs inhibiting matrix metalloproteinase (MMPs) were disappointing. Recently, we demonstrated that mature endothelial cells (ECs) and endothelial colony forming cel...

    Authors: Anastasia Chillà, Cecilia Anceschi, Elena Frediani, Francesca Scavone, Tommaso Del Rosso, Giuseppe Pelagio, Antonio Tufaro, Giuseppe De Palma, Mario Del Rosso, Gabriella Fibbi, Paola Chiarugi, Anna Laurenzana and Francesca Margheri
    Citation: Journal of Translational Medicine 2023 21:102
  7. Infantile hemangioma (IH) is the most common tumor among infants, but the exact pathogenesis of IH is largely unknown. Our previous study revealed that glucose metabolism may play an important role in the path...

    Authors: Kaiying Yang, Tong Qiu, Jiangyuan Zhou, Xue Gong, Xuepeng Zhang, Yuru Lan, Zixin Zhang and Yi Ji
    Citation: Journal of Translational Medicine 2023 21:85
  8. Recurrence is common in glioblastoma multiforme (GBM) because of the infiltrative, residual cells in the tumor margin. Standard therapy for GBM consists of surgical resection followed by chemotherapy and radio...

    Authors: Hanwool Jeon, Joonho Byun, Hayeong Kang, Kyunggon Kim, Eunyeup Lee, Jeong Hoon Kim, Chang Ki Hong, Sang Woo Song, Young-Hoon Kim, Sangjoon Chong, Jae Hyun Kim, Soo Jeong Nam, Ji Eun Park and Seungjoo Lee
    Citation: Journal of Translational Medicine 2023 21:69
  9. Lactate accumulation leads to an acidic tumor microenvironment (TME), in turn promoting colorectal cancer (CRC) progression. Tumor-associated macrophages (TAMs) are the predominant cells in TME. This study aim...

    Authors: Xinyi Gao, Shiqi Zhou, Zhaofu Qin, Dechuan Li, Yuping Zhu and Dening Ma
    Citation: Journal of Translational Medicine 2023 21:53
  10. Glioma is the most prevalent primary tumor of the central nervous system. Glioblastoma multiforme (GBM) is the most malignant form of glioma with an extremely poor prognosis. A novel, regulated cell death form...

    Authors: Yujie Zhou, Dongdong Xiao, Xiaobing Jiang and Chuansheng Nie
    Citation: Journal of Translational Medicine 2023 21:28
  11. Idiopathic pulmonary fibrosis is a chronic progressive, lethal disease in which ectopic lung fibroblast (LF) activation plays a vital part. We have previously shown that alamandine (ALA) exerts anti-fibrosis e...

    Authors: Wei Wang, Yue Zhang, Wenhui Huang, Yafei Yuan, Qiaohui Hong, Zhanzhan Xie, Lijuan Li, Yixin Chen, Xu Li and Ying Meng
    Citation: Journal of Translational Medicine 2023 21:24
  12. The 5-year survival rate of patients with head and neck squamous cell carcinoma (HNSCC) remains  < 50%. Hypoxia patterns are a hallmark of HNSCC that are associated with its occurrence and progression. However...

    Authors: Cong Peng, Huiping Ye, Zhengyang li, Xiaofeng Duan, Wen Yang and Zhuguang Yi
    Citation: Journal of Translational Medicine 2023 21:15
  13. Osteosarcoma (OS) is the most frequent cancer derived from bone, and the prognosis of OS is poor. Metabolic alterations have been previously reported to contribute to the development of OS, and arsenic compoun...

    Authors: Yixin Liu, Wenyan She, Yi Li, Miao Wang, Yin Liu, Biao Ning, Tianzi Xu, Tianhe Huang and Yongchang Wei
    Citation: Journal of Translational Medicine 2023 21:7
  14. Angiogenesis is involved in many pathological and physiological processes and is mainly driven by hypoxia. Karyopherin subunit alpha 2 (KPNA2), a member of the nuclear transport protein family, was recently sh...

    Authors: Yujie Jia, Qi Wang, Minglu Liang and Kai Huang
    Citation: Journal of Translational Medicine 2022 20:627
  15. Renal clear cell carcinoma (ccRCC) is the most prevalent tumors worldwide. Discovering effective biomarkers is essential to monitor the prognosis and provide alternative clinical options. SPTBN1 is implicated ...

    Authors: Jiajin Wu, Chenkui Miao, Yuhao Wang, Songbo Wang, Zhongyuan Wang, Yiyang Liu, Xiaoyi Wang and Zengjun Wang
    Citation: Journal of Translational Medicine 2022 20:603
  16. The poor prognosis of ovarian cancer patients is strongly related to peritoneal metastasis with the production of malignant ascites. However, it remains largely unclear how ascites in the peritoneal cavity inf...

    Authors: Qianlu Yang, Gyuntae Bae, Giorgi Nadiradze, Arianna Castagna, Georgy Berezhnoy, Laimdota Zizmare, Aditi Kulkarni, Yogesh Singh, Frank J. Weinreich, Stefan Kommoss, Marc A. Reymond and Christoph Trautwein
    Citation: Journal of Translational Medicine 2022 20:581
  17. Epithelial ovarian cancer is the most lethal gynaecological cancer worldwide. Chemotherapy resistance represents a significant clinical challenge and is the main reason for poor ovarian cancer prognosis. We id...

    Authors: Dilys Leung, Zoe K. Price, Noor A. Lokman, Wanqi Wang, Lizamarie Goonetilleke, Elif Kadife, Martin K. Oehler, Carmela Ricciardelli, George Kannourakis and Nuzhat Ahmed
    Citation: Journal of Translational Medicine 2022 20:556
  18. Exosomes are deemed to be an important tool of intercellular communicators in cancer cells. Our study investigated the role of PRR34 long non-coding RNA antisense RNA 1 (PRR34-AS1) in regulating exosome secret...

    Authors: Zhilei Zhang, Ye Zhou, Yuming Jia, Chao Wang, Meng Zhang and Zhuo Xu
    Citation: Journal of Translational Medicine 2022 20:491
  19. Colorectal cancer (CRC) is the third most common cancer and leading cause of cancer-related deaths worldwide. Aberrant cellular metabolism is a hallmark of cancer cells, and disturbed metabolism showed clinica...

    Authors: Zhan Wang, Miao-Miao Wang, Yan Geng, Chen-Yang Ye and Yuan-Sheng Zang
    Citation: Journal of Translational Medicine 2022 20:402
  20. Lung cancer is the second cancer and the leading cause of tumor-related mortality worldwide. Angiogenesis is a crucial hallmark of cancer development and a promising target in lung cancer. However, the anti-an...

    Authors: Yajie Liao, Xudong Wu, Mengyu Wu, Yuan Fang, Jie Li and Weiqiang Tang
    Citation: Journal of Translational Medicine 2022 20:349
  21. Doxorubicin (Dox) is the standard treatment approach for osteosarcoma (OS), while acquired drug resistance seriously attenuates its treatment efficiency. The present study aimed to investigate the potential ro...

    Authors: Qing He, Peng Hao, Gang He, Hantao Mai, Wenzhou Liu, Weiqiong Zhang, Kelin Zhang, Guifang Zhong, Ruilian Guo, Changzhi Yu, Yang Li, Chipiu Wong, Qian Chen and Yantao Chen
    Citation: Journal of Translational Medicine 2022 20:348
  22. The identification of early plasma biomarkers for clinical outcomes and drug resistance has key importance for risk stratification in anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer ...

    Authors: Shasha Wang, Ning Lou, Rongrong Luo, Xuezhi Hao, Yutao Liu, Lin Wang, Yuankai Shi and Xiaohong Han
    Citation: Journal of Translational Medicine 2022 20:248
  23. Platinum based agents—cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistan...

    Authors: Shruthi Sriramkumar, Riddhi Sood, Thomas D. Huntington, Ahmed H. Ghobashi, Truc T. Vuong, Tara X. Metcalfe, Weini Wang, Kenneth P. Nephew and Heather M. O’Hagan
    Citation: Journal of Translational Medicine 2022 20:246
  24. Prostatic cancer (PCa) is one of the most common malignant tumors in men worldwide. Emerging evidence indicates significance of hypoxia and immunity in PCa invasion and metastasis. This study aimed to develop ...

    Authors: Fang Lyu, Yunxue Li, Zhecheng Yan, Qingliu He, Lulin Cheng, Pu Zhang, Bing Liu, Chunyu Liu, Yarong Song and Yifei Xing
    Citation: Journal of Translational Medicine 2022 20:202
  25. 90% of esophageal cancer are esophageal squamous cell carcinoma (ESCC) and ESCC has a very poor prognosis and high mortality. Nevertheless, the key metabolic pathways associated with ESCC progression haven’t b...

    Authors: Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng and Qingchen Wu
    Citation: Journal of Translational Medicine 2022 20:127
  26. Targeting glutamine metabolism is previously indicated as a potential and attractive strategy for gastric cancer (GC) therapy. However, the underlying mechanisms responsible for the modification of glutamine m...

    Authors: Haofeng Liu, Qiu Xue, Hongzhou Cai, Xiaohui Jiang, Guangxin Cao, Tie Chen, Yuan Chen and Ding Wang
    Citation: Journal of Translational Medicine 2022 20:120
  27. Colorectal cancer (CRC) is one of the lethal cancers with a high mortality rate worldwide and understanding the mechanisms behind its progression is critical for improving patients’ prognosis and developing th...

    Authors: Yu Liu, Wentao Tang, Li Ren, Tianyu Liu, Meng Yang, Ye Wei, Yijiao Chen, Meiling Ji, Guosong Chen, Wenju Chang and Jianmin Xu
    Citation: Journal of Translational Medicine 2022 20:106
  28. The tumor microenvironment (TME) plays an important role in the occurrence and development of gastric cancer (GC) and is widely used to assess the treatment outcomes of GC patients. Immunohistochemistry (IHC) ...

    Authors: Tao Chen, Xunjun Li, Qingyi Mao, Yiyun Wang, Hanyi Li, Chen Wang, Yuyang Shen, Erjia Guo, Qinglie He, Jie Tian, Mansheng Zhu, Jing Wu, Weiqi Liang, Hao Liu, Jiang Yu and Guoxin Li
    Citation: Journal of Translational Medicine 2022 20:100
  29. Lung cancer remains a huge challenge to public health because of its high incidence and mortality, and lung adenocarcinoma (LUAD) is the main subtype of lung cancer. Hypoxia-induced vascular endothelial growth...

    Authors: Zhi Xia, Jian Xiao, Ziyu Dai and Qiong Chen
    Citation: Journal of Translational Medicine 2022 20:72
  30. Cutaneous melanoma exhibits heterogeneous metastatic patterns and prognosis. In this regard, liver metastasis, which is detected in ~ 10–20% of stage 4 patients, came to the fore of melanoma research, as it re...

    Authors: Sebastian A. Wohlfeil, Verena Häfele, Bianca Dietsch, Céline Weller, Carsten Sticht, Anna Sophia Jauch, Manuel Winkler, Christian David Schmid, Anna Lena Irkens, Ana Olsavszky, Kai Schledzewski, Philipp-Sebastian Reiners-Koch, Sergij Goerdt and Cyrill Géraud
    Citation: Journal of Translational Medicine 2022 20:62
  31. Loss-of-function mutations or abnormal expressions of E ubiquitin ligases contributes to tumorigenesis. TRIM38 was reported to regulate immunity, inflammatory responses or apoptosis, but its roles in tumor pro...

    Authors: Xiaojing Wang, Hongchao He, Wenbin Rui, Ning Zhang, Yu Zhu and Xin Xie
    Citation: Journal of Translational Medicine 2021 19:508
  32. Prostate cancer (PCa) belongs to an epithelial malignancy that occurs in the prostate gland and is the most common malignancy of the male genitourinary system. Referring to related literature, circSERPINA3 has...

    Authors: Zengshu Xing, Sailian Li, Zhenxiang Liu, Chong Zhang and Zhiming Bai
    Citation: Journal of Translational Medicine 2021 19:492
  33. Glycolysis affects tumor growth, invasion, chemotherapy resistance, and the tumor microenvironment. In this study, we aimed to construct a glycolysis-related prognostic model for ovarian cancer and analyze its...

    Authors: Jianlei Bi, Fangfang Bi, Xue Pan and Qing Yang
    Citation: Journal of Translational Medicine 2021 19:382
  34. Angiogenesis is the process of capillary sprouting from pre-existing vessels and it plays a critical role in the carcinogenic process of lung adenocarcinoma (LUAD). However, the association of angiogenesis reg...

    Authors: Songhua Cai, Xiaotong Guo, Chujian Huang, Youjun Deng, Longde Du, Wenyi Liu, Chenglin Yang, Hongbo Zhao, Kai Ma, Lixu Wang, Jie He and Zhentao Yu
    Citation: Journal of Translational Medicine 2021 19:361
  35. Accumulating evidence highlights the critical roles of fibroblast growth factors (FGFs) in regulating the progression of multiple human cancers, including non-small cell lung cancer (NSCLC). In this study, we ...

    Authors: Xiaowei Wu, Minjie Li, Ying Li, Yu Deng, Shun Ke, Fan Li, Yujin Wang and Shuchang Zhou
    Citation: Journal of Translational Medicine 2021 19:353
  36. Tumor-associated macrophages (TAM) are immunosuppressive cells that contribute to impaired anti-cancer immunity. Iron plays a critical role in regulating macrophage function. However, it is still elusive wheth...

    Authors: Jia-Lei Sun, Ning-Ping Zhang, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Weinire Abuduwaili, Fu Wang, Xiang-Nan Yu, Xuan Shi, Guang-Qi Song, Hao Wu, Tao-Tao Liu, Xi-Zhong Shen, Bin Deng, Shu-Qiang Weng, Ling Dong…
    Citation: Journal of Translational Medicine 2021 19:347
  37. Metabolic reprograming have been associated with cancer occurrence and progression within the tumor immune microenvironment. However, the prognostic potential of metabolism-related genes in colorectal cancer (...

    Authors: Dagui Lin, Wenhua Fan, Rongxin Zhang, Enen Zhao, Pansong Li, Wenhao Zhou, Jianhong Peng and Liren Li
    Citation: Journal of Translational Medicine 2021 19:279
  38. Currently, no molecular classification is established for bladder cancer based on metabolic characteristics. Therefore, we conducted a comprehensive analysis of bladder cancer metabolism-related genes using mu...

    Authors: Chaozhi Tang, Meng Yu, Jiakang Ma and Yuyan Zhu
    Citation: Journal of Translational Medicine 2021 19:205
  39. Liver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or hepatocellular carcinoma (HCC), seriously affecting the qual...

    Authors: Jingyao Cai, Min Hu, Zhiyang Chen and Zeng Ling
    Citation: Journal of Translational Medicine 2021 19:186