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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. NorthCape4000 (NC4000) is the most participated ultra-endurance cycling race. Eight healthy male Caucasian amateur cyclists were evaluated: (a) before starting the preparation period; (b) in the week preceding...

    Authors: Maria Teresa Valenti, Michele Braggio, Arianna Minoia, Gianluigi Dorelli, Jessica Bertacco, Francesco Bertoldo, Mattia Cominacini, Tonia De Simone, Maria Grazia Romanelli, Lekhana Bhandary, Monica Mottes and Luca Dalle Carbonare
    Citation: Journal of Translational Medicine 2022 20:397
    Content type: Research Published on:

  2. The association between oral dysbiosis and chronic kidney disease (CKD) has gained increasing attention in recent years. Diabetes and hypertension are the most common conditions in CKD. However, a case–control...

    Authors: Fengping Liu, Jiayi Sheng, Lei Hu, Bin Zhang, Wei Guo, Yang Wang, Yifeng Gu, Peng Jiang, Hao Lin, Brako Lydia, Yifan Sun, Yifan Tang, Chaoqun Gu, Shichao Wei, Qixiao Zhai, Weiguo Chen…
    Citation: Journal of Translational Medicine 2022 20:387
    Content type: Research Published on:

  3. Recently, a few studies have indicated a relationship between the gut microbiota and IgA nephropathy (IgAN). Whether the gut microbiota participates in the pathogenesis of IgAN and whether probiotics are effec...

    Authors: Jiaxing Tan, Lingqiu Dong, Zheng Jiang, Li Tan, Xinyao Luo, Gaiqin Pei, Aiya Qin, Zhengxia Zhong, Xiang Liu, Yi Tang and Wei Qin
    Citation: Journal of Translational Medicine 2022 20:382
    Content type: Research Published on:

  4. Currently, there is no approved medication for non-alcoholic fatty liver disease management. Pre-clinical and clinical studies showed that several bioactive molecules in plants or foods (i.e., curcumin complex...

    Authors: Yvelise Ferro, Roberta Pujia, Elisa Mazza, Lidia Lascala, Oscar Lodari, Samantha Maurotti, Arturo Pujia and Tiziana Montalcini
    Citation: Journal of Translational Medicine 2022 20:377
    Content type: Research Published on:

  5. Adopting healthy lifestyles and staying mentally health are two cost-effective modifiable strategies that cancer survivors can implement in self-management. We aimed to evaluate the independent, mediation, int...

    Authors: Zhao-yan Liu, Chen Wang, Yao-jun Zhang and Hui-lian Zhu
    Citation: Journal of Translational Medicine 2022 20:376
    Content type: Research Published on:

  6. The role of trimethylamine-N-oxide (TMAO) in the development of diabetes remains controversial, and prospective data are few. We aimed to investigate the association between serum TMAO and incident type 2 diab...

    Authors: Shu-yi Li, Si Chen, Xiao-ting Lu, Ai-ping Fang, Yu-ming Chen, Rong-zhu Huang, Xin-lei Lin, Zi-hui Huang, Jing-fei Ma, Bi-xia Huang and Hui-lian Zhu
    Citation: Journal of Translational Medicine 2022 20:374
    Content type: Research Published on:

  7. There is limited evidence regarding the impact of pregnancy loss on the subsequent risk of metabolic disorders. We aimed to investigate whether history of pregnancy loss is associated with the subsequent risk ...

    Authors: Maryam Rahmati, Marzieh Saei Ghare Naz, Fereidoun Azizi and Fahimeh Ramezani Tehrani
    Citation: Journal of Translational Medicine 2022 20:372
    Content type: Research Published on:

  8. Primary hyperparathyroidism (PHPT) is mainly caused by parathyroid adenoma, which produces excess parathyroid hormones. Its pathogenic mechanisms have not yet been fully understood. To investigate the mechanis...

    Authors: Wen-Xuan Zhou, Shu Wang, Ting-Chao Wu, Ling-Chao Cheng, Yao Du, Wei Wu, Chen Lin, Xin-Ying Li and Zhong-Liang Hu
    Citation: Journal of Translational Medicine 2022 20:368
    Content type: Research Published on:

  9. To compare efficacy and safety of fecal microbiota transplantation (FMT) with glucocorticoid as induction therapy in ulcerative colitis (UC).

    Authors: Chunlan Huang, Zehua Huang, Ling Ding, Yang Fu, Junjie Fan, Qixiang Mei, Lihong Lou, Jingjing Wang, Nuoming Yin, Yingying Lu, Sanwei Guo and Yue Zeng
    Citation: Journal of Translational Medicine 2022 20:354
    Content type: Research Published on:

  10. Several studies suggest that dietary fiber intake may reduce mortality risk, but this might depend on the fiber types and the evidence regarding the role of soluble fiber or insoluble fiber on death risk remai...

    Authors: Xin Xu, Junmiao Zhang, Yanhui Zhang, Honggang Qi and Ping Wang
    Citation: Journal of Translational Medicine 2022 20:344
    Content type: Research Published on:

  11. NAFLD and NASH are emerging as primary causes of chronic liver disease, indicating a need for an effective treatment. Mutaflor® probiotic, a microbial treatment of interest, was effective in sustaining remissi...

    Authors: Noha M. Hany, Sanaa Eissa, Manal Basyouni, Amany H. Hasanin, Yasmin M. Aboul-Ela, Nagwa M. Abo Elmagd, Iman F. Montasser, Mahmoud A. Ali, Paul J. Skipp and Marwa Matboli
    Citation: Journal of Translational Medicine 2022 20:342
    Content type: Research Published on:

  12. Vascular endothelial growth factor B (VEGFB) was regarded to improve lipid metabolism and reduce obesity-related hyperlipidemia. Whether VEGFB participates in lipid metabolism in nonalcoholic fatty liver disea...

    Authors: Rongrong Li, Yuqi Li, Xueling Yang, Yaorui Hu, Haining Yu and Yana Li
    Citation: Journal of Translational Medicine 2022 20:341
    Content type: Research Published on:

  13. Physical independence is crucial for overall health in the elderly individuals. The life expectancy of women has been shown to be higher than that of men, which is also known as the “male–female health-surviva...

    Authors: Qiao Zhu, Ping Ping, Pei Zhang, Chaoxue Ning, Yali Zhao, Yao Yao, Xiubing Li and Shihui Fu
    Citation: Journal of Translational Medicine 2022 20:340
    Content type: Research Published on:

  14. Hyperkalemia is a common and potentially life-threatening electrolyte disorder in maintenance hemodialysis (MHD) patients. This study aimed to evaluate the efficacy and safety of potassium-lowering regimens du...

    Authors: Lan Yao, Xiaoyang Xing, Yubao Li, Fangxing Zhang, Ping Li, Xianhui Liang and Pei Wang
    Citation: Journal of Translational Medicine 2022 20:333
    Content type: Research Published on:

  15. The oral ecosystem conditions dental health, and is known to be positively modified by oral hygiene which cannot always be performed between meals, especially outside home. It is therefore important to identif...

    Authors: Erna Cecilia Lorenzini, Barbara Lazzari, Gianluca Martino Tartaglia, Giampietro Farronato, Valentina Lanteri, Sara Botti, Filippo Biscarini, Paolo Cozzi and Alessandra Stella
    Citation: Journal of Translational Medicine 2022 20:312
    Content type: Research Published on:

  17. The development of diabetes vascular calcification (VC) is tightly associated with the inhibition of vascular smooth muscle cell (VSMC) autophagy. Previously, our team found that miR-32-5p (miR-32) promotes ma...

    Authors: Jingsong Cao, Cong Chen, Qian Chen, Yan Gao, Zhibo Zhao, Qing Yuan, Anqi Li, Shiqi Yang, Yuqi He, Xuyu Zu and Jianghua Liu
    Citation: Journal of Translational Medicine 2022 20:307
    Content type: Research Published on:

  18. Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and has become a huge public health issue worldwide. Inhibition of nucleotide oligomerization domain-like receptors con...

    Authors: Chao Wu, Yanqin Bian, Bingjie Lu, Dan Wang, Nisma Lena Bahaji Azami, Gang Wei, Feng Ma and Mingyu Sun
    Citation: Journal of Translational Medicine 2022 20:294
    Content type: Research Published on:

  19. Bariatric surgery is an effective therapy for individuals with severe obesity to achieve sustainable weight loss and to reduce comorbidities. Examining the molecular signature of subcutaneous adipose tissue (S...

    Authors: Annie Bouchard-Mercier, Juan de Toro-Martín, Mélanie Nadeau, Odette Lescelleur, Stéfane Lebel, Denis Richard, Laurent Biertho, André Tchernof and Marie-Claude Vohl
    Citation: Journal of Translational Medicine 2022 20:283
    Content type: Research Published on:

  20. Adipose tissue homeostasis is at the heart of many metabolic syndromes such as diabetes. Previously it has been demonstrated that adipose tissues from diabetic patients are senescent but whether this contribut...

    Authors: Hao Lin, Xiaonan Chen, Jianan Pan, Jiahan Ke, Alian Zhang, Yangyang Liu, Changqian Wang, Alex Chia Yu Chang and Jun Gu
    Citation: Journal of Translational Medicine 2022 20:278
    Content type: Research Published on:

  21. Conventional and unconventional lipid parameters are associated with diabetes risk, the comparative studies on lipid parameters for predicting future diabetes risk, however, are still extremely limited, and th...

    Authors: Guotai Sheng, Maobin Kuang, Ruijuan Yang, Yanjia Zhong, Shuhua Zhang and Yang Zou
    Citation: Journal of Translational Medicine 2022 20:266
    Content type: Research Published on:

  22. Currently, remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation are considered the principal residual cardiovascular risk (RCVR) factors. This study sought to evaluate the combined impact of RC, ...

    Authors: Hui-Hui Liu, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Rui-Xia Xu, Qian Dong, Jie Qian, Ke-Fei Dou and Jian-Jun Li
    Citation: Journal of Translational Medicine 2022 20:243
    Content type: Research Published on:

  23. Physical activity (PA) may protect against infertility by modulating the hypothalamic-pituitary–gonadal axis, thereby reducing gonadotropin levels, elevating immune function, and inhibiting inflammation and ci...

    Authors: Fangfang Xie, Yanli You, Chong Guan, Yuanjia Gu, Fei Yao and Jiatuo Xu
    Citation: Journal of Translational Medicine 2022 20:237
    Content type: Review Published on:

  24. Cardiometabolic disease (CMD) increases the risk of mortality, but the extent to which this can be offset by adherence to a healthy lifestyle is unknown. We aimed to investigate whether and to what extent a co...

    Authors: Chenjie Xu and Zhi Cao
    Citation: Journal of Translational Medicine 2022 20:234
    Content type: Research Published on:

  25. Familial hypercholesterolemia (FH) is a metabolic disease in which patients are prone to develop premature atherosclerosis (AS). Sorbin and SH3 Domain Containing 2 (SORBS2) is known to play a role in coronary ...

    Authors: Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Chuan-Jue Cui and Jian-Jun Li
    Citation: Journal of Translational Medicine 2022 20:233
    Content type: Research Published on:

  26. In 2010, November 16th, the Mediterranean diet was given the recognition of UNESCO as an “Intangible Heritage of Humanity” as this dietary pattern is rooted in the preservation of tradition, land, and biodiver...

    Authors: Annamaria Colao, Claudia Vetrani, Giovanna Muscogiuri, Luigi Barrea, Antonia Tricopoulou, Laura Soldati and Prisco Piscitelli
    Citation: Journal of Translational Medicine 2022 20:232
    Content type: Commentary Published on:

  27. Cigarette smoking (CS) is a strong risk factor for idiopathic pulmonary fibrosis (IPF). It can activate lung fibroblasts (LF) by inducing redox imbalance. We previously showed that clearing mitochondrial react...

    Authors: Yue Zhang, Ting Li, Miaoxia Pan, Wei Wang, Wenhui Huang, Yafei Yuan, Zhanzhan Xie, Yixin Chen, Jun Peng, Xu Li and Ying Meng
    Citation: Journal of Translational Medicine 2022 20:222
    Content type: Research Published on:

  28. Diabetic retinopathy (DR), especially proliferative diabetic retinopathy (PDR) is a common cause of blindness and visual impairment. Early prediction of its occurrence and progression is important to improved ...

    Authors: Huan Wang, Zhen Guo and Yu Xu
    Citation: Journal of Translational Medicine 2022 20:219
    Content type: Research Published on:

  29. Early diagnosis and treatment of chronic pancreatitis (CP) are limited. In this study, St13, a co-chaperone protein, was investigated whether it constituted a novel regulatory target in CP. Meanwhile, we evalu...

    Authors: Rong-chang Cao, Wan-jun Yang, Wang Xiao, Lei Zhou, Jie-hui Tan, Meng Wang, Zhi-tao Zhou, Huo-ji Chen, Jia Xu, Xue-mei Chen, Yang-chen Jin, Jia-yu Lin, Jun-ling Zeng, Shu-ji Li, Min Luo, Guo-dong Hu…
    Citation: Journal of Translational Medicine 2022 20:218
    Content type: Research Published on:

  30. The 2019 coronavirus disease pandemic (COVID-19) poses an enormous threat to public health worldwide, and the ensuing management of social isolation has greatly decreased opportunities for physical activity (P...

    Authors: Xiong Chen, Xiaosi Hong, Wenjing Gao, Shulu Luo, Jiahao Cai, Guochang Liu and Yinong Huang
    Citation: Journal of Translational Medicine 2022 20:216
    Content type: Research Published on:

  31. Post-cardiac surgery acute kidney injury (AKI) is associated with increased mortality. A high-protein meal enhances the renal blood flow and glomerular filtration rate (GFR) and might protect the kidneys from ...

    Authors: Faeq Husain-Syed, David R. Emlet, Jochen Wilhelm, Tommaso Hinna Danesi, Fiorenza Ferrari, Pércia Bezerra, Salvador Lopez-Giacoman, Gianluca Villa, Khodr Tello, Horst-Walter Birk, Werner Seeger, Davide Giavarina, Loris Salvador, Dana Y. Fuhrman, John A. Kellum and Claudio Ronco
    Citation: Journal of Translational Medicine 2022 20:204
    Content type: Research Published on:

  32. The circadian system is responsible for regulating various physiological activities and behaviors and has been gaining recognition. The circadian rhythm is adjusted in a 24-h cycle and has transcriptional–tran...

    Authors: Nai-Wei Hsu, Kai-Chen Chou, Yu-Ting Tina Wang, Chung-Lieh Hung, Chien-Feng Kuo and Shin-Yi Tsai
    Citation: Journal of Translational Medicine 2022 20:190
    Content type: Research Published on:

  33. Microlbuminuria is the earliest clinical evidence of diabetic kidney disease (DKD) and contributes to the induction and/or progression of DKD. Previous studies have shown that increased expression of angiopoie...

    Authors: Jing Liu, Junxia Yao, Yi Zhao, Jinxuan Su, Jiajia Ye and Yumei Wang
    Citation: Journal of Translational Medicine 2022 20:185
    Content type: Research Published on:

  34. Insulin resistance (IR) during gestational diabetes mellitus (GDM) has been linked to dysregulated insulin-PI3K/Akt pathway. A defective insulin-PI3K/Akt pathway and dysregulated circular RNA (circRNA) levels ...

    Authors: Runyu Du, Na Wu, Yu Bai, Lei Tang and Ling Li
    Citation: Journal of Translational Medicine 2022 20:180
    Content type: Research Published on:

  35. Metabolic syndrome (MetS) is a prevalent multifactorial disorder that can increase the risk of developing diabetes, cardiovascular diseases, and cancer. We aimed to compare different machine learning classific...

    Authors: Mahdi Akbarzadeh, Nadia Alipour, Hamed Moheimani, Asieh Sadat Zahedi, Firoozeh Hosseini-Esfahani, Hossein Lanjanian, Fereidoun Azizi and Maryam S. Daneshpour
    Citation: Journal of Translational Medicine 2022 20:164
    Content type: Research Published on:

  36. Dementia indicates a significant disease burden worldwide with increased population aging. This study aimed to investigate the impact of alcohol consumption on the risk of cognitive impairment in older adults.

    Authors: Fu-Shun Yen, Shiow-Ing Wang, Shih-Yi Lin, Yung-Hsiang Chao and James Cheng-Chung Wei
    Citation: Journal of Translational Medicine 2022 20:155
    Content type: Research Published on:

  37. Diabetic nephropathy (DN), the most common microvascular complication in patients with diabetes, induces kidney failure. Previous research showed that endothelial-to-mesenchymal transition (EndMT) of human glo...

    Authors: Xue Li, Lihong Lu, Wenting Hou, Fei Wang, Ting Huang, Zhipeng Meng and Minmin Zhu
    Citation: Journal of Translational Medicine 2022 20:147
    Content type: Research Published on:

  39. Osteoporosis is a disease threatening the health of millions of individuals. Melatonin is found to be a potential anti-osteoporosis drug. However, whether melatonin plays a role against osteoporosis at differe...

    Authors: Huanshuai Guan, Ning Kong, Run Tian, Ruomu Cao, Guanzhi Liu, Yiyang Li, Qilu Wei, Ming Jiao, Yutian Lei, Fangze Xing, Peng Tian, Kunzheng Wang and Pei Yang
    Citation: Journal of Translational Medicine 2022 20:132
    Content type: Research Published on:

  40. Asthma is a common respiratory disease, and immune system dysregulation has direct relevance to asthma pathogenesis. Probiotics and prebiotics have immunomodulatory effects and can regulate immune responses an...

    Authors: Zhiwei Wu, Entezar Mehrabi Nasab, Poonam Arora and Seyyed Shamsadin Athari
    Citation: Journal of Translational Medicine 2022 20:130
    Content type: Research Published on:

  41. Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases and has no safe and effective drug for treatment. We have previously reported the function of blueberry, but the effective monomer a...

    Authors: Juanjuan Zhu, Yuan Wen, Qiuling Zhang, Fei Nie, Mingliang Cheng and Xueke Zhao
    Citation: Journal of Translational Medicine 2022 20:128
    Content type: Research Published on:

  42. Sepsis is defined as a systemic inflammatory response to microbial infections with multiple organ dysfunction. This study analysed untargeted metabolomics combined with proteomics of serum from patients with s...

    Authors: Qi Chen, Xi Liang, Tianzhou Wu, Jing Jiang, Yongpo Jiang, Sheng Zhang, Yanyun Ruan, Huaping Zhang, Chao Zhang, Peng Chen, Yuhang Lv, Jiaojiao Xin, Dongyan Shi, Xin Chen, Jun Li and Yinghe Xu
    Citation: Journal of Translational Medicine 2022 20:123
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2022 20:366

  43. Body roundness index (BRI) is one of the obesity-related anthropometric indices. However, studies on the relationship between BRI and diabetes risk is limited. The purpose of this study was to explore the rela...

    Authors: Liling Wu, Hailu Pu, Man Zhang, Haofei Hu and Qijun Wan
    Citation: Journal of Translational Medicine 2022 20:110
    Content type: Research Published on:

  44. Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension...

    Authors: Chen Tang, Hanxiang Jiang, Bin Zhao, Yi Lin, Shengnan Lin, Tianmu Chen, Yanhua Su, Yiqin Zhang, Lina Zhou, Lianmeng Li, Jincheng Lin, Zhonghua Lu, Yao Wang, Zeyu Zhao, Longjian Liu, Yuxin Wang…
    Citation: Journal of Translational Medicine 2022 20:108
    Content type: Research Published on:

  45. Plasma lipid profile and anthropometric variables are known to be under strong genetic control and the identification of genetic variants associated with bioclinical parameters is of considerable public health...

    Authors: Benedetta Perrone, Paola Ruffo, Samanta Zelasco, Cinzia Giordano, Catia Morelli, Ines Barone, Stefania Catalano, Sebastiano Andò, Diego Sisci, Giovanni Tripepi, Corrado Mammì, Daniela Bonofiglio and Francesca Luisa Conforti
    Citation: Journal of Translational Medicine 2022 20:107
    Content type: Research Published on:

  46. This study aimed to use bioinformatics methods to characterize epigenetic changes in terms of micro-RNA(miRNA) expression and DNA methylation during adipogenesis. The mRNA and miRNA expression microarray and D...

    Authors: Yong Zhang, Fancheng Chen, Fangxue Zhang and Xiaowei Huang
    Citation: Journal of Translational Medicine 2022 20:93
    Content type: Research Published on:

  47. Type 2 diabetes mellitus (T2DM) is caused by a combination of environmental, genetic, and epigenetic factors including, fasting blood glucose (FBG), genetic variant rs841853, and cg19693031 methylation. We eva...

    Authors: Hao-Hung Tsai, Chao-Yu Shen, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Oswald Ndi Nfor, Shin-Lin Chiu, Ying-Hsiang Chou and Yung-Po Liaw
    Citation: Journal of Translational Medicine 2022 20:87
    Content type: Research Published on:

  48. Abnormal maternal lipid concentrations are associated with increased risk of preeclampsia. However, previous studies mainly focused on fasting lipid concentrations, scarce data have been published on the relat...

    Authors: Qing Liu, Zhihong Zhu, Wen Cai, Liu Yang, ShuangDi Li and Jiarong Zhang
    Citation: Journal of Translational Medicine 2022 20:81
    Content type: Research Published on:

  49. High intensity interval training (HIIT) has been reported to exert better effects on cardiovascular fitness in obesity, but little known about the arterial stiffness (AS) in female university students with nor...

    Authors: Jingyun Hu, Min Liu, Ruoyu Yang, Liyan Wang, Leichao Liang, Yuanyuan Yang, Shihao Jia, Ruiyi Chen, Qianle Liu, Yu Ren, Lei Zhu and Ming Cai
    Citation: Journal of Translational Medicine 2022 20:60
    Content type: Research Published on:

  50. Diabetic nephropathy (DN) is one of the main complications of diabetes, and oxidative stress plays an important role in its progression. NAD(P)H: quinone oxidoreductase 1 (NQO1) protects cells from oxidative s...

    Authors: Duojun Qiu, Shan Song, Yuhan Wang, Yawei Bian, Ming Wu, Haijiang Wu, Yonghong Shi and Huijun Duan
    Citation: Journal of Translational Medicine 2022 20:44
    Content type: Research Published on:
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