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Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Cardiometabolic disease (CMD) increases the risk of mortality, but the extent to which this can be offset by adherence to a healthy lifestyle is unknown. We aimed to investigate whether and to what extent a co...

    Authors: Chenjie Xu and Zhi Cao
    Citation: Journal of Translational Medicine 2022 20:234
  2. Familial hypercholesterolemia (FH) is a metabolic disease in which patients are prone to develop premature atherosclerosis (AS). Sorbin and SH3 Domain Containing 2 (SORBS2) is known to play a role in coronary ...

    Authors: Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Chuan-Jue Cui and Jian-Jun Li
    Citation: Journal of Translational Medicine 2022 20:233
  3. In 2010, November 16th, the Mediterranean diet was given the recognition of UNESCO as an “Intangible Heritage of Humanity” as this dietary pattern is rooted in the preservation of tradition, land, and biodiver...

    Authors: Annamaria Colao, Claudia Vetrani, Giovanna Muscogiuri, Luigi Barrea, Antonia Tricopoulou, Laura Soldati and Prisco Piscitelli
    Citation: Journal of Translational Medicine 2022 20:232
  4. Cigarette smoking (CS) is a strong risk factor for idiopathic pulmonary fibrosis (IPF). It can activate lung fibroblasts (LF) by inducing redox imbalance. We previously showed that clearing mitochondrial react...

    Authors: Yue Zhang, Ting Li, Miaoxia Pan, Wei Wang, Wenhui Huang, Yafei Yuan, Zhanzhan Xie, Yixin Chen, Jun Peng, Xu Li and Ying Meng
    Citation: Journal of Translational Medicine 2022 20:222
  5. Diabetic retinopathy (DR), especially proliferative diabetic retinopathy (PDR) is a common cause of blindness and visual impairment. Early prediction of its occurrence and progression is important to improved ...

    Authors: Huan Wang, Zhen Guo and Yu Xu
    Citation: Journal of Translational Medicine 2022 20:219
  6. Early diagnosis and treatment of chronic pancreatitis (CP) are limited. In this study, St13, a co-chaperone protein, was investigated whether it constituted a novel regulatory target in CP. Meanwhile, we evalu...

    Authors: Rong-chang Cao, Wan-jun Yang, Wang Xiao, Lei Zhou, Jie-hui Tan, Meng Wang, Zhi-tao Zhou, Huo-ji Chen, Jia Xu, Xue-mei Chen, Yang-chen Jin, Jia-yu Lin, Jun-ling Zeng, Shu-ji Li, Min Luo, Guo-dong Hu…
    Citation: Journal of Translational Medicine 2022 20:218
  7. The 2019 coronavirus disease pandemic (COVID-19) poses an enormous threat to public health worldwide, and the ensuing management of social isolation has greatly decreased opportunities for physical activity (P...

    Authors: Xiong Chen, Xiaosi Hong, Wenjing Gao, Shulu Luo, Jiahao Cai, Guochang Liu and Yinong Huang
    Citation: Journal of Translational Medicine 2022 20:216
  8. Post-cardiac surgery acute kidney injury (AKI) is associated with increased mortality. A high-protein meal enhances the renal blood flow and glomerular filtration rate (GFR) and might protect the kidneys from ...

    Authors: Faeq Husain-Syed, David R. Emlet, Jochen Wilhelm, Tommaso Hinna Danesi, Fiorenza Ferrari, Pércia Bezerra, Salvador Lopez-Giacoman, Gianluca Villa, Khodr Tello, Horst-Walter Birk, Werner Seeger, Davide Giavarina, Loris Salvador, Dana Y. Fuhrman, John A. Kellum and Claudio Ronco
    Citation: Journal of Translational Medicine 2022 20:204
  9. The circadian system is responsible for regulating various physiological activities and behaviors and has been gaining recognition. The circadian rhythm is adjusted in a 24-h cycle and has transcriptional–tran...

    Authors: Nai-Wei Hsu, Kai-Chen Chou, Yu-Ting Tina Wang, Chung-Lieh Hung, Chien-Feng Kuo and Shin-Yi Tsai
    Citation: Journal of Translational Medicine 2022 20:190
  10. Microlbuminuria is the earliest clinical evidence of diabetic kidney disease (DKD) and contributes to the induction and/or progression of DKD. Previous studies have shown that increased expression of angiopoie...

    Authors: Jing Liu, Junxia Yao, Yi Zhao, Jinxuan Su, Jiajia Ye and Yumei Wang
    Citation: Journal of Translational Medicine 2022 20:185
  11. Insulin resistance (IR) during gestational diabetes mellitus (GDM) has been linked to dysregulated insulin-PI3K/Akt pathway. A defective insulin-PI3K/Akt pathway and dysregulated circular RNA (circRNA) levels ...

    Authors: Runyu Du, Na Wu, Yu Bai, Lei Tang and Ling Li
    Citation: Journal of Translational Medicine 2022 20:180
  12. Metabolic syndrome (MetS) is a prevalent multifactorial disorder that can increase the risk of developing diabetes, cardiovascular diseases, and cancer. We aimed to compare different machine learning classific...

    Authors: Mahdi Akbarzadeh, Nadia Alipour, Hamed Moheimani, Asieh Sadat Zahedi, Firoozeh Hosseini-Esfahani, Hossein Lanjanian, Fereidoun Azizi and Maryam S. Daneshpour
    Citation: Journal of Translational Medicine 2022 20:164
  13. Dementia indicates a significant disease burden worldwide with increased population aging. This study aimed to investigate the impact of alcohol consumption on the risk of cognitive impairment in older adults.

    Authors: Fu-Shun Yen, Shiow-Ing Wang, Shih-Yi Lin, Yung-Hsiang Chao and James Cheng-Chung Wei
    Citation: Journal of Translational Medicine 2022 20:155
  14. Diabetic nephropathy (DN), the most common microvascular complication in patients with diabetes, induces kidney failure. Previous research showed that endothelial-to-mesenchymal transition (EndMT) of human glo...

    Authors: Xue Li, Lihong Lu, Wenting Hou, Fei Wang, Ting Huang, Zhipeng Meng and Minmin Zhu
    Citation: Journal of Translational Medicine 2022 20:147
  15. Osteoporosis is a disease threatening the health of millions of individuals. Melatonin is found to be a potential anti-osteoporosis drug. However, whether melatonin plays a role against osteoporosis at differe...

    Authors: Huanshuai Guan, Ning Kong, Run Tian, Ruomu Cao, Guanzhi Liu, Yiyang Li, Qilu Wei, Ming Jiao, Yutian Lei, Fangze Xing, Peng Tian, Kunzheng Wang and Pei Yang
    Citation: Journal of Translational Medicine 2022 20:132
  16. Asthma is a common respiratory disease, and immune system dysregulation has direct relevance to asthma pathogenesis. Probiotics and prebiotics have immunomodulatory effects and can regulate immune responses an...

    Authors: Zhiwei Wu, Entezar Mehrabi Nasab, Poonam Arora and Seyyed Shamsadin Athari
    Citation: Journal of Translational Medicine 2022 20:130
  17. Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases and has no safe and effective drug for treatment. We have previously reported the function of blueberry, but the effective monomer a...

    Authors: Juanjuan Zhu, Yuan Wen, Qiuling Zhang, Fei Nie, Mingliang Cheng and Xueke Zhao
    Citation: Journal of Translational Medicine 2022 20:128
  18. Sepsis is defined as a systemic inflammatory response to microbial infections with multiple organ dysfunction. This study analysed untargeted metabolomics combined with proteomics of serum from patients with s...

    Authors: Qi Chen, Xi Liang, Tianzhou Wu, Jing Jiang, Yongpo Jiang, Sheng Zhang, Yanyun Ruan, Huaping Zhang, Chao Zhang, Peng Chen, Yuhang Lv, Jiaojiao Xin, Dongyan Shi, Xin Chen, Jun Li and Yinghe Xu
    Citation: Journal of Translational Medicine 2022 20:123
  19. Body roundness index (BRI) is one of the obesity-related anthropometric indices. However, studies on the relationship between BRI and diabetes risk is limited. The purpose of this study was to explore the rela...

    Authors: Liling Wu, Hailu Pu, Man Zhang, Haofei Hu and Qijun Wan
    Citation: Journal of Translational Medicine 2022 20:110
  20. Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension...

    Authors: Chen Tang, Hanxiang Jiang, Bin Zhao, Yi Lin, Shengnan Lin, Tianmu Chen, Yanhua Su, Yiqin Zhang, Lina Zhou, Lianmeng Li, Jincheng Lin, Zhonghua Lu, Yao Wang, Zeyu Zhao, Longjian Liu, Yuxin Wang…
    Citation: Journal of Translational Medicine 2022 20:108
  21. Plasma lipid profile and anthropometric variables are known to be under strong genetic control and the identification of genetic variants associated with bioclinical parameters is of considerable public health...

    Authors: Benedetta Perrone, Paola Ruffo, Samanta Zelasco, Cinzia Giordano, Catia Morelli, Ines Barone, Stefania Catalano, Sebastiano Andò, Diego Sisci, Giovanni Tripepi, Corrado Mammì, Daniela Bonofiglio and Francesca Luisa Conforti
    Citation: Journal of Translational Medicine 2022 20:107
  22. This study aimed to use bioinformatics methods to characterize epigenetic changes in terms of micro-RNA(miRNA) expression and DNA methylation during adipogenesis. The mRNA and miRNA expression microarray and D...

    Authors: Yong Zhang, Fancheng Chen, Fangxue Zhang and Xiaowei Huang
    Citation: Journal of Translational Medicine 2022 20:93
  23. Type 2 diabetes mellitus (T2DM) is caused by a combination of environmental, genetic, and epigenetic factors including, fasting blood glucose (FBG), genetic variant rs841853, and cg19693031 methylation. We eva...

    Authors: Hao-Hung Tsai, Chao-Yu Shen, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Oswald Ndi Nfor, Shin-Lin Chiu, Ying-Hsiang Chou and Yung-Po Liaw
    Citation: Journal of Translational Medicine 2022 20:87
  24. Abnormal maternal lipid concentrations are associated with increased risk of preeclampsia. However, previous studies mainly focused on fasting lipid concentrations, scarce data have been published on the relat...

    Authors: Qing Liu, Zhihong Zhu, Wen Cai, Liu Yang, ShuangDi Li and Jiarong Zhang
    Citation: Journal of Translational Medicine 2022 20:81
  25. High intensity interval training (HIIT) has been reported to exert better effects on cardiovascular fitness in obesity, but little known about the arterial stiffness (AS) in female university students with nor...

    Authors: Jingyun Hu, Min Liu, Ruoyu Yang, Liyan Wang, Leichao Liang, Yuanyuan Yang, Shihao Jia, Ruiyi Chen, Qianle Liu, Yu Ren, Lei Zhu and Ming Cai
    Citation: Journal of Translational Medicine 2022 20:60
  26. Body mass index (BMI) and physical activity (PA) has been documented to be associated with cardiovascular disease (CVD). However, the evidences regarding joint phenotypes of BMI and PA trajectories with risk f...

    Authors: Qiuyue Tian, Biyan Wang, Shuohua Chen, Shouling Wu and Youxin Wang
    Citation: Journal of Translational Medicine 2022 20:45
  27. Diabetic nephropathy (DN) is one of the main complications of diabetes, and oxidative stress plays an important role in its progression. NAD(P)H: quinone oxidoreductase 1 (NQO1) protects cells from oxidative s...

    Authors: Duojun Qiu, Shan Song, Yuhan Wang, Yawei Bian, Ming Wu, Haijiang Wu, Yonghong Shi and Huijun Duan
    Citation: Journal of Translational Medicine 2022 20:44
  28. Very Low-Calorie Ketogenic Diet (VLCKD) is currently a promising approach for the treatment of obesity. However, little is known about the side effects since most of the studies reporting them were carried out...

    Authors: Luigi Barrea, Ludovica Verde, Claudia Vetrani, Francesca Marino, Sara Aprano, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2022 20:23
  29. Atherosclerosis is a chronic inflammatory disease caused mainly by lipid accumulation and excessive inflammatory immune response. Although the lipid-lowering and cardioprotective properties of bilirubin, as we...

    Authors: Guanmei Wen, Leyi Yao, Yali Hao, Jinheng Wang and Jinbao Liu
    Citation: Journal of Translational Medicine 2022 20:1
  30. Cardiometabolic diseases (CMD) are recognized as the main causes of morbidity and mortality in developed countries. In recent years eating speed (ES) has been of particular interest since some studies have ass...

    Authors: Luigi Barrea, Claudia Vetrani, Ludovica Verde, Bruno Napolitano, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2021 19:530
  31. Although the presence of physical signs [tendon xanthomas and/or corneal arcus (TX/CA)], are associated with the risk of coronary artery disease in patients with heterozygous familial hypercholesterolemia (HeF...

    Authors: Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong and Jian-Jun Li
    Citation: Journal of Translational Medicine 2021 19:498
  32. Fecal microbiota transplantation (FMT) is considered an effective treatment for slow transit constipation (STC); nevertheless, the mechanism remains unclear.

    Authors: Lulu Xie, Chen Xu, Yadong Fan, Yuwei Li, Ying Wang, Xiaoyu Zhang, Shuang Yu, Jida Wang, Rundong Chai, Zeyu Zhao, Yutong Jin, Zhe Xu, Shuwu Zhao and Yuhong Bian
    Citation: Journal of Translational Medicine 2021 19:490
  33. Secretory phospholipase A2 group IIA (sPLA2-IIA) is an independent risk factor for cardiovascular disease, but its role on high-density lipoprotein cholesterol (HDL-C) level has not been clarified. The aim of ...

    Authors: Ling Liang, Qiang Xie, Changqing Sun, Yuanhui Wu, Wei Zhang and Weihua Li
    Citation: Journal of Translational Medicine 2021 19:484
  34. Obesity is associated with chronic low-grade inflammation, contributing to an increasing prevalence of chronic metabolic diseases, such as insulin resistance, non-alcoholic fatty liver disease (NALFD), and ste...

    Authors: Jingchang Ma, Wei Hu, Dongliang Zhang, Jiangang Xie, Chujun Duan, Yitian Liu, Yuling Wang, Xuexue Xu, Kun Cheng, Boquan Jin, Yuan Zhang and Ran Zhuang
    Citation: Journal of Translational Medicine 2021 19:477
  35. MicroRNA-146a-5p (miR-146a-5p) is a key regulator of inflammatory processes. Expression of miR-146a-5p is altered in target organs of diabetic complications and deficiency of miR-146a-5p has been implicated in...

    Authors: Federica Barutta, Beatrice Corbetta, Stefania Bellini, Simonetta Guarrera, Giuseppe Matullo, Michela Scandella, Casper Schalkwijk, Coen D. Stehouwer, Nish Chaturvedi, Sabita S. Soedamah-Muthu, Marilena Durazzo and Gabriella Gruden
    Citation: Journal of Translational Medicine 2021 19:475
  36. It is well known that malnutrition is a frequent co-morbidity in cancer patients, especially in those with head and neck neoplasms. This may be due both to the presence of dysphagia symptoms and to the appeara...

    Authors: Maria Giulia Cristofaro, Ida Barca, Francesco Ferragina, Daniela Novembre, Yvelise Ferro, Roberta Pujia and Tiziana Montalcini
    Citation: Journal of Translational Medicine 2021 19:472
  37. Diabetes mellitus (DM), a most common chronic disease, is featured with impaired endothelial function and bioavailability of nitric oxide (NO), while E3 ubiquitin ligase appears to alleviate endothelial dysfun...

    Authors: Qingsong Jin, Liangyan Lin, Tiantian Zhao, Xiaoyan Yao, Yaqin Teng, Dongdong Zhang, Yongjun Jin and Meizi Yang
    Citation: Journal of Translational Medicine 2021 19:469
  38. Osteosarcoma (OS) is the most frequent primary bone cancer, affecting mostly children and adolescents. Although much progress has been made throughout the years towards treating primary OS, the 5-year survival...

    Authors: Taiana Campos Leite, Rebecca Jean Watters, Kurt Richard Weiss and Giuseppe Intini
    Citation: Journal of Translational Medicine 2021 19:450
  39. Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of bitterness. Although in the fir...

    Authors: Kamila Tuzim and Agnieszka Korolczuk
    Citation: Journal of Translational Medicine 2021 19:440

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:478

  40. The number of older people is estimated to increase from 524 million in 2010 to 1.5 billion in 2050. The factors and models of human longevity and successful aging are questions that have intrigued individuals...

    Authors: Shihui Fu, Ping Ping, Yulong Li, Bo Li, Yali Zhao, Yao Yao and Pei Zhang
    Citation: Journal of Translational Medicine 2021 19:436
  41. Human milk is a vehicle for bioactive compounds and beneficial bacteria which promote the establishment of a healthy gut microbiome of newborns, especially of preterm infants. Pasteurized donor human milk (PDH...

    Authors: D. Mallardi, C. Tabasso, P. Piemontese, S. Morandi, T. Silvetti, F. Biscarini, P. Cremonesi, B. Castiglioni, V. Pica, M. Stuknyte, I. De Noni, O. Amato, N. Liotto, F. Mosca and P. Roggero
    Citation: Journal of Translational Medicine 2021 19:420
  42. Peritoneal dialysis (PD) is a form of dialysis to replace the function of kidney, that uses the peritoneum as a dialysis membrane to remove metabolites and water retained in the body. Vitamin D deficiency is p...

    Authors: Chi Zhang, Junsheng Wang, Xiaohui Xie and Dong Sun
    Citation: Journal of Translational Medicine 2021 19:411
  43. Metabolism is one of the most complex cellular biochemical reactions, providing energy and substances for basic activities such as cell growth and proliferation. Early studies have shown that glucose is an imp...

    Authors: Beibei Luo, Xin Zhou, Qingming Tang, Ying Yin, Guangxia Feng, Shue Li and Lili Chen
    Citation: Journal of Translational Medicine 2021 19:410
  44. Sphingosine Kinase (SphK) that catalyzes sphingosine (Sph) to sphingosine 1-phosphate (S1P), plays a key role in both sphingolipid metabolism and cellular signaling. While SphK has been implicated in type 2 di...

    Authors: Qi Chen, Wei Wang, Ming-Feng Xia, You-li Lu, Hua Bian, Chen Yu, Xiao-Ying Li, Mathew A. Vadas, Xin Gao, Huan-Dong Lin and Pu Xia
    Citation: Journal of Translational Medicine 2021 19:393
  45. Gestational diabetes mellitus (GDM) is a serious public health issue affecting 9–15% of all pregnancies worldwide. Recently, it has been suggested that extracellular vesicles (EVs) play a role throughout gesta...

    Authors: Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacós, Fátima Crispi, Gregory Duncombe, Martha Lappas…
    Citation: Journal of Translational Medicine 2021 19:360

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