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Cell, tissue and gene therapy

Section edited by David Stroncek

This section aims to improve communication between basic and clinical research related to cell, tissue and gene therapies. Effective clinical therapies require efficient translation of research between the bench and bedside to allow the discovery, development, scale up, and production of cells, tissues and vectors. These therapies are being used to treat patients with a range of diseases including cancer, cardiovascular diseases, autoimmune disorders.

Studies considered for publication include those regarding the nature of cells, tissues and vectors used in clinical therapies; methods to collect, isolate and modify cells; and novel reagents, equipment, and instruments used in production. The section also welcomes research into the application of clinical therapies; factors that effect the safety and efficacy; in particular the potency, stability and purity of cells or tissue; and issues related to the safety of cell and tissue donors.

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  1. Content type: Research

    Machine perfusion (MP) of kidney graft provides benefits against preservation injury, however decreased graft quality requires optimization of the method. We examined the chronic benefits of MP on kidney graft...

    Authors: Raphael Thuillier, Ricardo Codas, Etienne Marchand, Hubert Lathelize, Olivier Page, Alexandre Valagier, Lionel Badet and Thierry Hauet

    Citation: Journal of Translational Medicine 2012 10:233

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  2. Content type: Research

    GADD45B is a member of the growth arrest DNA damage-inducible gene family associated with cell growth control, apoptosis, and DNA damage repair response. The aim of this study is to detect the role of GADD45B ...

    Authors: Lisha Wang, Xiuying Xiao, Dali Li, Yayun Chi, Ping Wei, Yiqin Wang, Shujuan Ni, Cong Tan, Xiaoyan Zhou and Xiang Du

    Citation: Journal of Translational Medicine 2012 10:215

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  3. Content type: Research

    Inactivaion of tumor suppressor genes (TSGs) by promoter CpG methylation frequently occurs in tumorigenesis, even in the early stages, contributing to the initiation and progression of human cancers. Deleted in l...

    Authors: Zhaohui Wang, Lili Li, Xianwei Su, Zifen Gao, Gopesh Srivastava, Paul G Murray, Richard Ambinder and Qian Tao

    Citation: Journal of Translational Medicine 2012 10:209

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  4. Content type: Research

    Endometrial regenerative cells (ERC) and bone marrow stromal cells (BMSC) are being used in clinical trials. While they have been reported to have similar characteristics, they have not been directly compared.

    Authors: Huan Wang, Ping Jin, Marianna Sabatino, Jiaqiang Ren, Sara Civini, Vladimir Bogin, Thomas E Ichim and David F Stroncek

    Citation: Journal of Translational Medicine 2012 10:207

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  5. Content type: Research

    Fork head box M1 (FoxM1) is a proliferation-associated transcription factor essential for cell cycle progression. Numerous studies have documented that FoxM1 has multiple functions in tumorigenesis and its ele...

    Authors: Yi-Jun Xue, Ri-Hai Xiao, Da-Zhi Long, Xiao-Feng Zou, Xiao-Ning Wang, Guo-Xi Zhang, Yuan-Hu Yuan, Geng-Qing Wu, Jun Yang, Yu-Ting Wu, Hui Xu, Fo-Lin Liu and Min Liu

    Citation: Journal of Translational Medicine 2012 10:200

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  6. Content type: Research

    Embryonic stem cells (ESCs) are pluripotent stem cells and can form tumors containing cells from all three germ layers. Similarities between pluripotent stem cells and malignant tumor cells have been identifie...

    Authors: Xinrong Peng, Tao Liu, Ying Wang, Qiaoling Yan, Huajun Jin, Linfang Li, Qijun Qian and Mengchao Wu

    Citation: Journal of Translational Medicine 2012 10:196

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  7. Content type: Research

    During wound healing processes fibroblasts account for wound closure by adopting a contractile phenotype. One disease manifestation of COPD is emphysema which is characterized by destruction of alveolar walls ...

    Authors: Oskar Hallgren, Sara Rolandsson, Annika Andersson-Sjöland, Kristian Nihlberg, Elisabet Wieslander, Martina Kvist-Reimer, Magnus Dahlbäck, Leif Eriksson, Leif Bjermer, Jonas S Erjefält, Claes-Göran Löfdahl and Gunilla Westergren-Thorsson

    Citation: Journal of Translational Medicine 2012 10:171

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  8. Content type: Research

    Adipose tissue is an attractive source of cells for therapeutic purposes because of the ease of harvest and the high frequency of mesenchymal stem cells (MSCs). Whilst it is clear that MSCs have significant th...

    Authors: Sinead P Blaber, Rebecca A Webster, Cameron J Hill, Edmond J Breen, Donald Kuah, Graham Vesey and Benjamin R Herbert

    Citation: Journal of Translational Medicine 2012 10:172

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  9. Content type: Research

    Interferon regulatory factor (IRF)-5 is a transcription factor involved in type I interferon signaling whose germ line variants have been associated with autoimmune pathogenesis. Since relationships have been obs...

    Authors: Lorenzo Uccellini, Valeria De Giorgi, Yingdong Zhao, Barbara Tumaini, Narnygerel Erdenebileg, Mark E Dudley, Sara Tomei, Davide Bedognetti, Maria Libera Ascierto, Qiuzhen Liu, Richard Simon, Leah Kottyan, Kenneth M Kaufman, John B Harley, Ena Wang, Steven A Rosenberg…

    Citation: Journal of Translational Medicine 2012 10:170

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  10. Content type: Research

    Overexpression of GOLPH3 (Golgi phosphoprotein 3, 34 kDa) is associated with the progression of many solid tumor types leading to an unfavorable clinical outcome. We aimed to investigate the clinical significa...

    Authors: Huan Li, Ling Guo, Shu-Wei Chen, Xiao-Hui Zhao, Shi-Min Zhuang, Li-Ping Wang, Li-Bing Song and Ming Song

    Citation: Journal of Translational Medicine 2012 10:168

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  11. Content type: Research

    Recent data suggest that cancer stem cells (CSCs) play an important role in cancer, as these cells possess enhanced tumor-forming capabilities and are responsible for relapses after apparently curative therapi...

    Authors: Huiqiang Wang, Nanhai G Chen, Boris R Minev and Aladar A Szalay

    Citation: Journal of Translational Medicine 2012 10:167

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  12. Content type: Research

    Mucopolysaccharidoses (MPS) are severe metabolic disorders caused by accumulation of undegraded glycosaminoglycans (GAGs) in lysosomes due to defects in certain lysosomal hydrolases. Substrate reduction therap...

    Authors: Anna Kloska, Magdalena Narajczyk, Joanna Jakóbkiewicz-Banecka, Grzegorz Grynkiewicz, Wiesław Szeja, Magdalena Gabig-Cimińska and Grzegorz Węgrzyn

    Citation: Journal of Translational Medicine 2012 10:153

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  13. Content type: Research

    Special AT-rich sequence-binding protein-1 (SATB1) has been reported to be expressed in several human cancers and may have malignant potential. This study was aimed at investigating the expression and potentia...

    Authors: Sheng-Hua Chu, Yan-Bin Ma, Dong-Fu Feng, Hong Zhang, Zhi-An Zhu, Zhi-Qiang Li and Pu-Cha Jiang

    Citation: Journal of Translational Medicine 2012 10:149

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  14. Content type: Research

    Aptamer-based tumor targeted drug delivery system is a promising approach that may increase the efficacy of chemotherapy and reduce the related toxicity. HER2 protein is an attractive target for tumor-specific...

    Authors: Zhe Liu, Jin-Hong Duan, Yong-Mei Song, Jie Ma, Feng-Dan Wang, Xin Lu and Xian-Da Yang

    Citation: Journal of Translational Medicine 2012 10:148

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  15. Content type: Research

    Bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with coronary heart disease are impaired with respect to number and functional activity. However, the relation between the functional acti...

    Authors: Ilkay Bozdag-Turan, R Goekmen Turan, Lylia Paranskaya, Nicole S Arsoy, C Hakan Turan, Ibrahim Akin, Stephan Kische, Jasmin Ortak, H Schneider, S Ludovicy, Tina Hermann, Giuseppe D’Ancona, Serkan Durdu, A Ruchan Akar, Hueseyin Ince and Christoph A Nienaber

    Citation: Journal of Translational Medicine 2012 10:143

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  16. Content type: Research

    Adipose derived mesenchymal stem cells (ADMSCs), carrying the similar characteristics to bone marrow mesenchymal stem cells, only much more abundant and easier to obtain, may be a promising treatment for liver...

    Authors: Yu Wang, Fan Lian, Jiaping Li, Wenzhe Fan, Hanshi Xu, Xiuyan Yang, Liuqin Liang, Wei Chen and Jianyong Yang

    Citation: Journal of Translational Medicine 2012 10:133

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  17. Content type: Research

    It has been reported that the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway regulates erythropoietin (EPO)-induced survival, proliferation, and maturation of early erythroid progenitors. Erythroid...

    Authors: Vladan P Cokic, Bhaskar Bhattacharya, Bojana B Beleslin-Cokic, Constance T Noguchi, Raj K Puri and Alan N Schechter

    Citation: Journal of Translational Medicine 2012 10:116

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  18. Content type: Research

    Previous experimental studies concluded that stem cells (SC) may exert their beneficial effects on the ischemic heart by paracrine activation of antiapoptotic pathways. In order to identify potential cardiopro...

    Authors: Mark Rosenberg, Matthias Lutz, Constantin Kühl, Rainer Will, Volker Eckstein, Jutta Krebs, Hugo A Katus and Norbert Frey

    Citation: Journal of Translational Medicine 2012 10:115

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  19. Content type: Methodology

    The quality and safety of advanced therapy products must be maintained throughout their production and quality control cycle to ensure their final use in patients. We validated the cell count method according ...

    Authors: Monica Gunetti, Sara Castiglia, Deborah Rustichelli, Katia Mareschi, Fiorella Sanavio, Michela Muraro, Elena Signorino, Laura Castello, Ivana Ferrero and Franca Fagioli

    Citation: Journal of Translational Medicine 2012 10:112

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  20. Content type: Research

    Cerebral palsy is currently one of the major diseases that cause severe paralysis of the nervous system in children; approximately 9–30% of cerebral palsy patients are also visually impaired, for which no effe...

    Authors: Min Li, Aixue Yu, Fangfang Zhang, GuangHui Dai, Hongbin Cheng, Xiaodong Wang and Yihua An

    Citation: Journal of Translational Medicine 2012 10:100

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  21. Content type: Research

    In vitro fabricated tissue engineered vascular constructs could provide an alternative to conventional substitutes. A crucial factor for tissue engineering of vascular constructs is an appropriate cell source. Va...

    Authors: Bianca Polchow, Kati Kebbel, Gerno Schmiedeknecht, Anne Reichardt, Wolfgang Henrich, Roland Hetzer and Cora Lueders

    Citation: Journal of Translational Medicine 2012 10:98

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  22. Content type: Research

    We conducted a pilot study of the infusion of intravenous autologous cord blood (CB) in children with cerebral palsy (CP) to assess the safety and feasibility of the procedure as well as its potential efficacy...

    Authors: Young-Ho Lee, Kyung Vin Choi, Jin Hwa Moon, Hyun-Joo Jun, Hye-Ryeong Kang, Se-In Oh, Hyung Sun Kim, Jang Soo Um, Mi Jung Kim, Yun Young Choi, Young-Jun Lee, Hee-Jin Kim, Jong-Hwa Lee, Su Min Son, Soo-Jin Choi, Wonil Oh…

    Citation: Journal of Translational Medicine 2012 10:58

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  23. Content type: Research

    RhoA-Rho kinase complex contributes to keep the cavernosus smooth muscle contracted and its inhibition is considered a potential strategy for the therapy of erectile dysfunction (ED).

    Authors: Fabio Guagnini, Mara Ferazzini, Marco Grasso, Salvatore Blanco and Tiziano Croci

    Citation: Journal of Translational Medicine 2012 10:59

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  24. Content type: Research

    This study evaluated the effectiveness of treating pseudarthrosis in rats by using bone marrow cell suspensions or cultures of bone marrow mesenchymal stromal cells

    Authors: Manoel Luiz Ferreira, Paulo Cesar Silva, Lucas Henrique Alvarez Silva, Danielle Cabral Bonfim, Lucas Cristo Conilho Macedo Müller, Christiano Costa Espósito and Alberto Schanaider

    Citation: Journal of Translational Medicine 2012 10:51

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  25. Content type: Research

    Human adipose-derived mesenchymal stem cells (ADMSCs) may be ideal source of cells for intervertebral disc (IVD) regeneration, but the harsh chemical microenvironment of IVD may significantly influence the bio...

    Authors: Chengzhen Liang, Hao Li, Yiqing Tao, Xiaopeng Zhou, Fangcai Li, Gang Chen and Qixin Chen

    Citation: Journal of Translational Medicine 2012 10:49

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  26. Content type: Research

    A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly...

    Authors: David F Stroncek, Carolina Berger, Martin A Cheever, Richard W Childs, Mark E Dudley, Peter Flynn, Luca Gattinoni, James R Heath, Michael Kalos, Francesco M Marincola, Jeffrey S Miller, Gustavo Mostoslavsky, Daniel J Powell Jr, Mahendra Rao, Nicholas P Restifo, Steven A Rosenberg…

    Citation: Journal of Translational Medicine 2012 10:48

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  27. Content type: Research

    Hepatitis C virus (HCV) causes liver fibrosis that may lead to liver cirrhosis or hepatocellular carcinoma (HCC), and may partially depend on infecting viral genotype. HCV genotype 3a is being more common in A...

    Authors: Waqar Ahmad, Bushra Ijaz and Sajida Hassan

    Citation: Journal of Translational Medicine 2012 10:41

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  28. Content type: Research

    Diabetic patients are at increased risk for bacterial infections; these studies provide new insight into the role of the host defense complement system in controlling bacterial pathogens in hyperglycemic envir...

    Authors: Pamela S Hair, Charlene G Echague, Reuben D Rohn, Neel K Krishna, Julius O Nyalwidhe and Kenji M Cunnion

    Citation: Journal of Translational Medicine 2012 10:35

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  29. Content type: Methodology

    There has been significant progress in the last two decades on the design of chimeric antigen receptors (CAR) for adoptive immunotherapy targeting tumor-associated antigens. Structurally CARs consist of a sing...

    Authors: Zhili Zheng, Nachimuthu Chinnasamy and Richard A Morgan

    Citation: Journal of Translational Medicine 2012 10:29

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  30. Content type: Methodology

    Bone marrow stromal cells (BMSCs) are being used to treat a variety of conditions. For many applications a supply of cryopreserved products that can be used for acute therapy is needed. The establishment of a ...

    Authors: Marianna Sabatino, Jiaqiang Ren, Virginia David-Ocampo, Lee England, Michael McGann, Minh Tran, Sergei A Kuznetsov, Hanh Khuu, Arun Balakumaran, Harvey G Klein, Pamela G Robey and David F Stroncek

    Citation: Journal of Translational Medicine 2012 10:23

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  31. Content type: Research

    Osteoblast and adipocyte are derived from common mesenchymal progenitor cells. The bone loss of osteoporosis is associated with altered progenitor differentiation from an osteoblastic to an adipocytic lineage....

    Authors: Li You, Ling Pan, Lin Chen, Jin-Yu Chen, Xiaoping Zhang, Zhongwei Lv and Da Fu

    Citation: Journal of Translational Medicine 2012 10:11

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  32. Content type: Research

    For clinical applications, dendritic cells (DCs) need to be generated using GMP-approved reagents. In this study, we tested the characteristics of DCs generated in two clinical grade culture media and activate...

    Authors: Jitka Fučíková, Daniela Rožková, Hana Ulčová, Vít Budinský, Klára Sochorová, Kateřina Pokorná, Jiřina Bartůňková and Radek Špíšek

    Citation: Journal of Translational Medicine 2011 9:223

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  33. Content type: Research

    Breast cancer stem cells (BCSCs) are the source of breast tumors. Compared with other cancer cells, cancer stem cells show high resistance to both chemotherapy and radiotherapy. Targeting of BCSCs is thus a po...

    Authors: Phuc V Pham, Nhan LC Phan, Nhung T Nguyen, Nhung H Truong, Thuy T Duong, Dong V Le, Kiet D Truong and Ngoc K Phan

    Citation: Journal of Translational Medicine 2011 9:209

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  34. Content type: Research

    Erythropoietin (EPO) is a glycoprotein hormone which is required to regulate the production of red blood cells. Deficiency of EPO is known to cause anemia in chronically infected renal patients and they requir...

    Authors: Humera Kausar, Sana Gull, Bushra Ijaz, Waqar Ahmad, Muhammad Tahir Sarwar, Zafar Iqbal, Zafar Nawaz, Sheikh Riazuddin and Sajida Hassan

    Citation: Journal of Translational Medicine 2011 9:186

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  35. Content type: Research

    Chronic refractory angina is a challenging clinical problem with limited treatment options. The results of early cardiovascular stem cell trials using ABMMC have been promising but have utilized intracoronary ...

    Authors: Jorge Tuma, Roberto Fernández-Viña, Antonio Carrasco, Jorge Castillo, Carlos Cruz, Alvaro Carrillo, Jose Ercilla, Carlos Yarleque, Jaime Cunza, Timothy D Henry and Amit N Patel

    Citation: Journal of Translational Medicine 2011 9:183

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  36. Content type: Review

    Prolonged life expectancy, life style and environmental changes have caused a changing disease pattern in developed countries towards an increase of degenerative and autoimmune diseases. Stem cells have become...

    Authors: Jeong Chan Ra, Sung Keun Kang, Il Seob Shin, Hyeong Geun Park, Sang Aun Joo, Jeong Geun Kim, Byeong-Cheol Kang, Yong Soon Lee, Ken Nakama, Min Piao, Bertram Sohl and Andras Kurtz

    Citation: Journal of Translational Medicine 2011 9:181

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  37. Content type: Protocol

    Idiopathic pulmonary fibrosis represents a lethal form of progressive fibrotic lung disorder with gradually increasing incidence worldwide. Despite intense research efforts its pathogenesis is still elusive an...

    Authors: Argyris Tzouvelekis, George Koliakos, Paschalis Ntolios, Irene Baira, Evangelos Bouros, Anastasia Oikonomou, Athanassios Zissimopoulos, George Kolios, Despoina Kakagia, Vassilis Paspaliaris, Ioannis Kotsianidis, Marios Froudarakis and Demosthenes Bouros

    Citation: Journal of Translational Medicine 2011 9:182

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  38. Content type: Research

    Ten cancer patients (Six renal cell carcinoma and four breast cancer patients) were treated in a phase I/II study with a vaccine composed of autologous dendritic cells (DCs) and IL-2 to evaluate the DC vaccine...

    Authors: Soyoung Baek, Choung-Soo Kim, Sung-Bae Kim, Yong-man Kim, Seog-Woon Kwon, YongMan Kim, HyunSoo Kim and Hyunah Lee

    Citation: Journal of Translational Medicine 2011 9:178

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  39. Content type: Research

    This study tested the superiority of combined cyclosporine A (CsA)-erythropoietin (EPO) therapy compared with either one in limiting brain infarction area (BIA) and preserving neurological function in rat afte...

    Authors: Chun-Man Yuen, Cheuk-Kwan Sun, Yu-Chun Lin, Li-Teh Chang, Ying-Hsien Kao, Chia-Hung Yen, Yung-Lung Chen, Tzu-Hsien Tsai, Sarah Chua, Pei-Lin Shao, Steve Leu and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2011 9:141

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  40. Content type: Research

    Chronic inflammation plays an important role in head and neck squamous cell carcinomas (HNSCC). This study addresses the impact of two single nucleotide polymorphisms (SNP) Asp299Gly and Thr399Ile of the toll-...

    Authors: Christoph Bergmann, Hagen S Bachmann, Agnes Bankfalvi, Ramin Lotfi, Carolin Pütter, Clarissa A Wild, Patrick J Schuler, Jens Greve, Thomas K Hoffmann, Stephan Lang, André Scherag and Götz F Lehnerdt

    Citation: Journal of Translational Medicine 2011 9:139

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  41. Content type: Research

    Cardiomyocyte calcium overloading has been implicated in the pathogenesis of Duchenne muscular dystrophy (DMD) heart disease. The cardiac isoform of sarcoplasmic reticulum calcium ATPase (SERCA2a) plays a majo...

    Authors: Jin-Hong Shin, Brian Bostick, Yongping Yue, Roger Hajjar and Dongsheng Duan

    Citation: Journal of Translational Medicine 2011 9:132

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  42. Content type: Protocol

    Liver transplantation is the definitive treatment for many end-stage liver diseases. However, the life-long immunosuppression needed to prevent graft rejection causes clinically significant side effects. Cellu...

    Authors: Felix C Popp, Barbara Fillenberg, Elke Eggenhofer, Philipp Renner, Johannes Dillmann, Volker Benseler, Andreas A Schnitzbauer, James Hutchinson, Robert Deans, Deborah Ladenheim, Cheryl A Graveen, Florian Zeman, Michael Koller, Martin J Hoogduijn, Edward K Geissler, Hans J Schlitt…

    Citation: Journal of Translational Medicine 2011 9:124

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  43. Content type: Research

    This study tested the hypothesis that autologous transplantation of adipose-derived mesenchymal stem cells (ADMSCs) can effectively attenuate acute pulmonary ischemia-reperfusion (IR) injury.

    Authors: Cheuk-Kwan Sun, Chia-Hung Yen, Yu-Chun Lin, Tzu-Hsien Tsai, Li-Teh Chang, Ying-Hsien Kao, Sarah Chua, Morgan Fu, Sheung-Fat Ko, Steve Leu and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2011 9:118

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  44. Content type: Research

    Lipid metabolites and cytokines, including chemokines and growth factors, are the key regulators of immune cell function and differentiation, and thus, dysregulation of these regulators is associated with vari...

    Authors: Hyun Ok Kim, Han-Soo Kim, Jong-Chan Youn, Eui-Cheol Shin and Sungha Park

    Citation: Journal of Translational Medicine 2011 9:113

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  45. Content type: Review

    The field of cellular therapy of cancer is moving quickly and the issues involved with its advancement are complex and wide ranging. The growing clinical applications and success of adoptive cellular therapy o...

    Authors: Cornelis JM Melief, John J O'Shea and David F Stroncek

    Citation: Journal of Translational Medicine 2011 9:107

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  46. Content type: Research

    In our recent study, Periostin was up-regulated in prostate cancer(PCa) compared with benign prostate hyperplasia (BPH) by proteomics analysis of prostate biopsies. We investigated the effect of sliencing Peri...

    Authors: Chuanyu Sun, Xiaojun Zhao, Ke Xu, Jian Gong, Weiwei Liu, Weihong Ding, Yuancheng Gou, Guowei Xia and Qiang Ding

    Citation: Journal of Translational Medicine 2011 9:99

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  47. Content type: Research

    The F11 Receptor (F11R; aka JAM-A, JAM-1) is a cell adhesion protein present constitutively on the membrane surface of circulating platelets and within tight junctions of endothelial cells (ECs). Previous repo...

    Authors: Bani M Azari, Jonathan D Marmur, Moro O Salifu, Yigal H Ehrlich, Elizabeth Kornecki and Anna Babinska

    Citation: Journal of Translational Medicine 2011 9:98

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  48. Content type: Research

    Hemoglobin E/β-thalassemia is particularly common in Southeast Asia and has variable symptoms ranging from mild to severe anemia. Previous investigations demonstrated the remarkable symptoms of β-thalassemia i...

    Authors: Saranyoo Ponnikorn, Tasanee Panichakul, Kitima Sresanga, Chokdee Wongborisuth, Sittiruk Roytrakul, Suradej Hongeng and Sumalee Tungpradabkul

    Citation: Journal of Translational Medicine 2011 9:96

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  49. Content type: Research

    Reactive oxygen species are important mediators exerting toxic effects on various organs during ischemia-reperfusion (IR) injury. We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect th...

    Authors: Yen-Ta Chen, Cheuk-Kwan Sun, Yu-Chun Lin, Li-Teh Chang, Yung-Lung Chen, Tzu-Hsien Tsai, Sheng-Ying Chung, Sarah Chua, Ying-Hsien Kao, Chia-Hung Yen, Pei-Lin Shao, Kuan-Cheng Chang, Steve Leu and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2011 9:51

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  50. Content type: Review

    Emerging evidence suggests that cancer stem cells account for the initiation and progression of cancer. While many types of cancer stem cells with specific markers have been isolated and identified, a variety ...

    Authors: Hai-Guang Liu, Chong Chen, Han Yang, Yi-Fei Pan and Xiao-Hua Zhang

    Citation: Journal of Translational Medicine 2011 9:50

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