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Cell, tissue and gene therapy

Section edited by David Stroncek

This section aims to improve communication between basic and clinical research related to cell, tissue and gene therapies. Effective clinical therapies require efficient translation of research between the bench and bedside to allow the discovery, development, scale up, and production of cells, tissues and vectors. These therapies are being used to treat patients with a range of diseases including cancer, cardiovascular diseases, autoimmune disorders.

Studies considered for publication include those regarding the nature of cells, tissues and vectors used in clinical therapies; methods to collect, isolate and modify cells; and novel reagents, equipment, and instruments used in production. The section also welcomes research into the application of clinical therapies; factors that effect the safety and efficacy; in particular the potency, stability and purity of cells or tissue; and issues related to the safety of cell and tissue donors.

Featured articles

A therapeutic cancer vaccine against GL261 murine glioma
Mark S. Kindy, et al



Endothelium-targeted human Delta-like 1 enhances the regeneration and homing of human cord blood stem and progenitor cells
Deng-Mei Tian, Ying-Min Liang and Yong-Qing Zhang


Obesity inhibits the osteogenic differentiation of human adipose-derived stem cells
Amy L. Strong, et al

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  1. The quality and safety of cell therapy products must be maintained throughout their production and quality control cycle, ensuring their final use in the patient. We validated the Lymulus Amebocyte Lysate (LAL...

    Authors: Deborah Rustichelli, Sara Castiglia, Monica Gunetti, Katia Mareschi, Elena Signorino, Michela Muraro, Laura Castello, Fiorella Sanavio, Marco Leone, Ivana Ferrero and Franca Fagioli

    Citation: Journal of Translational Medicine 2013 11:197

    Content type: Methodology

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  2. Oncolytic viruses have shown potential as cancer therapeutics, but not all patients seem to benefit from therapy. Polymorphisms in Fc gamma receptors (FcgRs) lead to altered binding affinity of IgG between the...

    Authors: Mari Hirvinen, Raita Heiskanen, Minna Oksanen, Saila Pesonen, Ilkka Liikanen, Timo Joensuu, Anna Kanerva, Vincenzo Cerullo and Akseli Hemminki

    Citation: Journal of Translational Medicine 2013 11:193

    Content type: Research

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  3. The current study sought to investigate the safety of intraoperative and early postoperative continuous hyperthermic intraperitoneal perfusion (IEPCHIP) at different temperatures in a swine model of experiment...

    Authors: Sheng Li, Yong-lei Zhang, Jia-yuan Sun, Ya-wei Hua and Pei-hong Wu

    Citation: Journal of Translational Medicine 2013 11:181

    Content type: Research

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  4. Adipose-derived stromal cells (ADSCs) are a good alternative to multipotent stem cells for regenerative medicine. Low tidal volume (LVT) has proved to be an effective ventilation strategy. However, it is not k...

    Authors: Zuo Di Liang, Xiu Ru Yin, Da Sheng Cai, Heng Zhou and Ling Pei

    Citation: Journal of Translational Medicine 2013 11:179

    Content type: Research

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  5. Mesenchymal stem cells (MSCs) are known to be capable of suppressing inflammatory responses. We previously reported that intra-abdominal implantation of bone marrow-derived MSCs (BM-MSCs) sheet by laparotomy a...

    Authors: Xian-ming Fu, Aika Yamawaki-Ogata, Hideki Oshima, Yuichi Ueda, Akihiko Usui and Yuji Narita

    Citation: Journal of Translational Medicine 2013 11:175

    Content type: Research

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  6. Regenerative medicine and particular adult stem cells represent an alternative option with several fruitful therapeutic applications in patients suffering from chronic lung diseases including idiopathic pulmon...

    Authors: Argyris Tzouvelekis, Vassilis Paspaliaris, George Koliakos, Paschalis Ntolios, Evangelos Bouros, Anastasia Oikonomou, Athanassios Zissimopoulos, Nikolaos Boussios, Brian Dardzinski, Dimitrios Gritzalis, Antonis Antoniadis, Marios Froudarakis, George Kolios and Demosthenes Bouros

    Citation: Journal of Translational Medicine 2013 11:171

    Content type: Research

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  7. Glioblastoma multiforme (GBM) is one of the most aggressive forms of cancer with a high rate of recurrence. We propose a novel oncolytic vaccinia virus (VACV)-based therapy using expression of the bone morphog...

    Authors: Rohit Duggal, Ulrike Geissinger, Qian Zhang, Jason Aguilar, Nanhai G Chen, Elena Binda, Angelo L Vescovi and Aladar A Szalay

    Citation: Journal of Translational Medicine 2013 11:155

    Content type: Research

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  8. Colorectal cancer (CRC) remains one of the most common cancers worldwide. We observed that MUC20 was significantly up-regulated in CRC patients with poor prognosis based on the microarray analysis. However, li...

    Authors: Xiuying Xiao, Lisha Wang, Ping Wei, Yayun Chi, Dali Li, Qifeng Wang, Shujuan Ni, Cong Tan, Weiqi Sheng, Menghong Sun, Xiaoyan Zhou and Xiang Du

    Citation: Journal of Translational Medicine 2013 11:151

    Content type: Research

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  9. Peripheral vascular disease of the lower extremities comprises a clinical spectrum that extends from no symptoms to presentation with critical limb ischemia (CLI). Bone marrow derived Mesenchymal Stem Cells (B...

    Authors: Pawan K Gupta, Anoop Chullikana, Rajiv Parakh, Sanjay Desai, Anjan Das, Sanjay Gottipamula, Sagar Krishnamurthy, Naveen Anthony, Arun Pherwani and Anish S Majumdar

    Citation: Journal of Translational Medicine 2013 11:143

    Content type: Research

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  10. The α2-adrenoreceptor agonist dexmedetomidine is known to provide renoprotection against ischemia and reperfusion (I/R) injury. However the underlying molecular mechanisms remain unclear. The purpose of this stud...

    Authors: Yanna Si, Hongguang Bao, Liu Han, Hongwei Shi, Yuan Zhang, Li Xu, Chenhui Liu, Jinsong Wang, Xiaobing Yang, Akbar Vohra and Daqing Ma

    Citation: Journal of Translational Medicine 2013 11:141

    Content type: Research

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  11. While PDE5 inhibitors have revolutionized treatment of ED, approximately 30% of patients are non-responsive. A significant cause of this is vascular and smooth muscle dysfunction, as well as nerve atrophy. Aut...

    Authors: Thomas E Ichim, Timothy Warbington, Octav Cristea, Joseph L Chin and Amit N Patel

    Citation: Journal of Translational Medicine 2013 11:139

    Content type: Review

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  12. Modified cell-based angiogenic therapy has become a promising novel strategy for ischemic heart and limb diseases. Most studies focused on myoblast, endothelial cell progenitors or bone marrow mesenchymal stro...

    Authors: Evgeny K Shevchenko, Pavel I Makarevich, Zoya I Tsokolaeva, Maria A Boldyreva, Veronika Yu Sysoeva, Vsevolod A Tkachuk and Yelena V Parfyonova

    Citation: Journal of Translational Medicine 2013 11:138

    Content type: Research

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  13. In an attempt to engineer a regulatory compliant form of cell assisted lipotransfer in the U.S., the authors developed Autologous Fat Transfer with In-situ Mediation (AIM) for reconstruction of a refractory surgi...

    Authors: Allan Y Wu and David M Morrow

    Citation: Journal of Translational Medicine 2013 11:136

    Content type: Research

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    The Erratum to this article has been published in Journal of Translational Medicine 2014 12:269

  14. Endothelial progenitor cells (EPCs) contribute to tumor angiogenesis and growth. We previously reported that over-expression of an inhibitor of DNA binding/differentiation 1 (Id1) in EPCs can enhance EPC proli...

    Authors: Yajuan Su, Lingjuan Gao, Lichen Teng, Ying Wang, Jialin Cui, Shiyun Peng and Songbin Fu

    Citation: Journal of Translational Medicine 2013 11:132

    Content type: Research

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  15. Interactions between dendritic cells (DCs) and T cells play a critical role in the development of glomerulonephritis, which is a common cause of chronic kidney disease. DC-specific intercellular adhesion molec...

    Authors: Minchao Cai, Jing Wu, Chaoming Mao, Jianmin Ren, Pu Li, Xiao Li, Jiuchang Zhong, Chundi Xu and Tong Zhou

    Citation: Journal of Translational Medicine 2013 11:103

    Content type: Research

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  16. Hepatopulmonary syndrome (HPS) is characterized by advanced liver disease, hypoxemia and intrapulmonary vascular dilatation (IPVD). The pathogenesis of HPS is not completely understood. Recent findings have es...

    Authors: Bin Yi, Jing Zeng, Guansong Wang, Guisheng Qian and Kaizhi Lu

    Citation: Journal of Translational Medicine 2013 11:98

    Content type: Research

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  17. Mesenchymal stem cells (MSCs) are multi-potent non-hematopoietic progenitor cells possessing an immune-regulatory function, with suppression of proliferation of activated lymphocytes. In this study, adult livi...

    Authors: Hyunah Lee, Jae Berm Park, Sanghoon Lee, Soyoung Baek, HyunSoo Kim and Sung Joo Kim

    Citation: Journal of Translational Medicine 2013 11:96

    Content type: Research

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  18. Celiac disease (CD) is mainly characterised by villous atrophy and mucosal architectural rearrangement. The fibroblasts (FBs) are the most abundant mesenchymal cell type in the intestinal mucosa and are respon...

    Authors: Leda Roncoroni, Luca Elli, Maria Teresa Bardella, Gianluca Perrucci, Michele Ciulla, Vincenza Lombardo, Carolina Tomba, Dario Conte and Luisa Doneda

    Citation: Journal of Translational Medicine 2013 11:91

    Content type: Research

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  19. The use of adenoviral vector for gene therapy is still an important strategy for advanced cancers, however, the lack of the requisite coxsackie-adenovirus receptor in cancer cells and host immune response to a...

    Authors: Hua-shan Shi, Li-ping Yang, Wei Wei, Xiao-qing Su, Xiao-peng Li, Meng Li, Shun-tao Luo, Hai-long Zhang, Lian Lu, Yong-qiu Mao, Bing Kan and Li Yang

    Citation: Journal of Translational Medicine 2013 11:86

    Content type: Research

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  20. Angiogenesis is a critical part of the endogenous repair process in brain injury and disease, and requires at least two sequential steps. First, angiogenic sprouting of endothelial cells occurs, which entails ...

    Authors: Mo Dao, Ciara C Tate, Michael McGrogan and Casey C Case

    Citation: Journal of Translational Medicine 2013 11:81

    Content type: Research

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  21. Mesenchymal stem cell (MSC) transplantation has emerged as a promising therapy for liver fibrosis. Issues concerning poor MSC survival and engraftment in the fibrotic liver still persist and warrant developmen...

    Authors: Ghazanfar Ali Nasir, Sadia Mohsin, Mohsin Khan, Sulaiman Shams, Gibran Ali, Shaheen N Khan and Sheikh Riazuddin

    Citation: Journal of Translational Medicine 2013 11:78

    Content type: Research

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  22. Heart failure is one of the key causes of morbidity and mortality world-wide. The recent findings that regeneration is possible in the heart have made stem cell therapeutics the Holy Grail of modern cardiovasc...

    Authors: Leo Bockeria, Vladimir Bogin, Olga Bockeria, Tatyana Le, Bagrat Alekyan, Erik J Woods, Amalia A Brown, Thomas E Ichim and Amit N Patel

    Citation: Journal of Translational Medicine 2013 11:56

    Content type: Review

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  23. Age-related macular degeneration (AMD) is the leading cause of blindness in people over age 55 in the U.S. and the developed world. This condition leads to the progressive impairment of central visual acuity. ...

    Authors: Heather Melville, Matthew Carpiniello, Kia Hollis, Andrew Staffaroni and Nady Golestaneh

    Citation: Journal of Translational Medicine 2013 11:53

    Content type: Review

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  24. Experimental clinical stem cell therapy has been used for more than a decade to alleviate the adverse aftermath of acute myocardial infarction (aMI). The post-infarcted myocardial microenvironment is character...

    Authors: Ewa Przybyt, Guido Krenning, Marja GL Brinker and Martin C Harmsen

    Citation: Journal of Translational Medicine 2013 11:39

    Content type: Research

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  25. The early peritoneal invasion of epithelial ovarian cancer (EOC) by tumoral aggregates presents in ascites is a major concern. The role of the microenvironment seems to be important in this process but the lac...

    Authors: Cyril Touboul, Raphael Lis, Halema Al Farsi, Christophe M Raynaud, Mohamed Warfa, Hamda Althawadi, Eliane Mery, Massoud Mirshahi and Arash Rafii

    Citation: Journal of Translational Medicine 2013 11:28

    Content type: Research

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  26. The discovery of mesenchymal stem cells (MSCs) or MSC-like cells in cartilage tissue does not tie in well with the established view that MSCs derive from a perivascular niche. The presence of MSCs may raise co...

    Authors: Karin Benz, Claudia Stippich, Christian Freudigmann, Juergen A Mollenhauer and Wilhelm K Aicher

    Citation: Journal of Translational Medicine 2013 11:27

    Content type: Research

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  27. Linker for activation of T cells (LAT), a transmembrane adaptor protein, plays a role in T cell and mast cell function, while it remains unclear how histone modifications mediate LAT expression in allergic ast...

    Authors: Cheng-ye Li, Juan Peng, Lian-pin Ren, Li-xing Gan, Xiao-jiong Lu, Qian Liu, Wen Gu and Xue-jun Guo

    Citation: Journal of Translational Medicine 2013 11:26

    Content type: Research

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  28. Kidneys derived from brain dead donors have lower graft survival and higher graft-function loss compared to their living donor counterpart. Heat Shock Proteins (HSP) are a large family of stress proteins invol...

    Authors: Leon FA van Dullemen, Eelke M Bos, Theo A Schuurs, Harm H Kampinga, Rutger J Ploeg, Harry van Goor and Henri GD Leuvenink

    Citation: Journal of Translational Medicine 2013 11:22

    Content type: Research

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  29. Stem cell therapy is a promising treatment for cerebral palsy, which refers to a category of brain diseases that are associated with chronic motor disability in children. Autologous MSCs may be a better cell s...

    Authors: Guojun Chen, Yali Wang, Zhenyu Xu, Feng Fang, Renmei Xu, Yue Wang, Xiaoli Hu, Lixing Fan and Houqi Liu

    Citation: Journal of Translational Medicine 2013 11:21

    Content type: Research

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  30. Mesenchymal stem cells (MSC) can serve as carriers to deliver oncolytic measles virus (MV) to ovarian tumors. In preparation for a clinical trial to use MSC as MV carriers, we obtained cells from ovarian cance...

    Authors: Emily K Mader, Greg Butler, Sean C Dowdy, Andrea Mariani, Keith L Knutson, Mark J Federspiel, Stephen J Russell, Evanthia Galanis, Allan B Dietz and Kah-Whye Peng

    Citation: Journal of Translational Medicine 2013 11:20

    Content type: Research

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  31. ECBio has developed proprietary technology to consistently isolate, expand and cryopreserve a well-characterized population of stromal cells from human umbilical cord tissue (UCX® cells). The technology has re...

    Authors: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz and Helder Cruz

    Citation: Journal of Translational Medicine 2013 11:18

    Content type: Research

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  32. Pharmacologic reactivation of fetal hemoglobin expression is a promising strategy for treatment of sickle cell disease and β-thalassemia. The objective of this study was to investigate the effect of the methyl...

    Authors: Yinghong He, Gerhard Rank, Miaomiao Zhang, Junyi Ju, Ronghua Liu, Zhen Xu, Fiona Brown, Loretta Cerruti, Chi Ma, Renxiang Tan, Stephen M Jane and Quan Zhao

    Citation: Journal of Translational Medicine 2013 11:14

    Content type: Research

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  33. Interferon-γ (IFN-γ) is regarded as a potent antitumor agent, but its clinical application is limited by its short half-life and significant side effects. In this paper, we tried to develop IFN-γ gene therapy ...

    Authors: Ran-yi Liu, Ying-hui Zhu, Ling Zhou, Peng Zhao, Hong-li Li, Lan-cai Zhu, Hong-yu Han, Huan-xin Lin, Liang Kang, Jiang-xue Wu and Wenlin Huang

    Citation: Journal of Translational Medicine 2012 10:256

    Content type: Research

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  34. We tested whether apoptotic adipose-derived mesenchymal stem cells (A-ADMSCs) were superior to healthy (H)-ADMSCs at attenuating organ damage and mortality in sepsis syndrome following cecal ligation and punct...

    Authors: Chia-Lo Chang, Steve Leu, Hsin-Ching Sung, Yen-Yi Zhen, Chung-Lung Cho, Angela Chen, Tzu-Hsien Tsai, Sheng-Ying Chung, Han-Tan Chai, Cheuk-Kwan Sun, Chia-Hung Yen and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2012 10:244

    Content type: Research

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  35. Ischemia is the major cause of acute kidney injury (AKI), associated with high mortality and morbidity. Mesenchymal stem cells (MSCs) have multilineage differentiation potential and can be a potent therapeutic...

    Authors: Muhammad Shareef Masoud, Sanam Saiqa Anwar, Muhammad Zeeshan Afzal, Azra Mehmood, Shaheen N Khan and Sheikh Riazuddin

    Citation: Journal of Translational Medicine 2012 10:243

    Content type: Research

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  36. The secretory small GTPase Rab27b was recently identified as an oncogene in breast cancer (BC) in vivo and in vitro studies. This research was designed to further explore the clinical and prognostic significan...

    Authors: Jia-Xing Zhang, Xiao-Xia Huang, Man-Bo Cai, Zhu-Ting Tong, Jie-Wei Chen, Dong Qian, Yi-Ji Liao, Hai-Xia Deng, Ding-Zhun Liao, Ma-Yan Huang, Yi-Xin Zeng, Dan Xie and Shi-Juan Mai

    Citation: Journal of Translational Medicine 2012 10:242

    Content type: Research

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  37. The use of large animals as an experimental model for novel treatment techniques has many advantages over the use of laboratory animals, so veterinary medicine is becoming an increasingly important translation...

    Authors: Darja Pavlin, Maja Cemazar, Gregor Sersa and Natasa Tozon

    Citation: Journal of Translational Medicine 2012 10:234

    Content type: Review

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  38. Machine perfusion (MP) of kidney graft provides benefits against preservation injury, however decreased graft quality requires optimization of the method. We examined the chronic benefits of MP on kidney graft...

    Authors: Raphael Thuillier, Ricardo Codas, Etienne Marchand, Hubert Lathelize, Olivier Page, Alexandre Valagier, Lionel Badet and Thierry Hauet

    Citation: Journal of Translational Medicine 2012 10:233

    Content type: Research

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  39. Despite the successes of recombinant hematopoietic-stimulatory factors at accelerating bone marrow reconstitution and shortening the neutropenic period post-transplantation, significant challenges remain such ...

    Authors: J Christopher Mizer, Thomas E Ichim, Doru T Alexandrescu, Constantin A Dasanu, Famela Ramos, Andrew Turner, Erik J Woods, Vladimir Bogin, Michael P Murphy, David Koos and Amit N Patel

    Citation: Journal of Translational Medicine 2012 10:231

    Content type: Review

    Published on:

  40. Numerous preclinical and clinical studies have investigated the regenerative potential and the trophic support of mesenchymal stem cells (MSCs) following their injection into a target organ. Clinicians favor t...

    Authors: Murali Krishna Mamidi, Gurbind Singh, Juani Mazmin Husin, Kavitha Ganesan Nathan, Gopinath Sasidharan, Zubaidah Zakaria, Ramesh Bhonde, Anish Sen Majumdar and Anjan Kumar Das

    Citation: Journal of Translational Medicine 2012 10:229

    Content type: Research

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  41. GADD45B is a member of the growth arrest DNA damage-inducible gene family associated with cell growth control, apoptosis, and DNA damage repair response. The aim of this study is to detect the role of GADD45B ...

    Authors: Lisha Wang, Xiuying Xiao, Dali Li, Yayun Chi, Ping Wei, Yiqin Wang, Shujuan Ni, Cong Tan, Xiaoyan Zhou and Xiang Du

    Citation: Journal of Translational Medicine 2012 10:215

    Content type: Research

    Published on:

  42. Inactivaion of tumor suppressor genes (TSGs) by promoter CpG methylation frequently occurs in tumorigenesis, even in the early stages, contributing to the initiation and progression of human cancers. Deleted in l...

    Authors: Zhaohui Wang, Lili Li, Xianwei Su, Zifen Gao, Gopesh Srivastava, Paul G Murray, Richard Ambinder and Qian Tao

    Citation: Journal of Translational Medicine 2012 10:209

    Content type: Research

    Published on:

  43. Endometrial regenerative cells (ERC) and bone marrow stromal cells (BMSC) are being used in clinical trials. While they have been reported to have similar characteristics, they have not been directly compared.

    Authors: Huan Wang, Ping Jin, Marianna Sabatino, Jiaqiang Ren, Sara Civini, Vladimir Bogin, Thomas E Ichim and David F Stroncek

    Citation: Journal of Translational Medicine 2012 10:207

    Content type: Research

    Published on:

  44. Fork head box M1 (FoxM1) is a proliferation-associated transcription factor essential for cell cycle progression. Numerous studies have documented that FoxM1 has multiple functions in tumorigenesis and its ele...

    Authors: Yi-Jun Xue, Ri-Hai Xiao, Da-Zhi Long, Xiao-Feng Zou, Xiao-Ning Wang, Guo-Xi Zhang, Yuan-Hu Yuan, Geng-Qing Wu, Jun Yang, Yu-Ting Wu, Hui Xu, Fo-Lin Liu and Min Liu

    Citation: Journal of Translational Medicine 2012 10:200

    Content type: Research

    Published on:

  45. Embryonic stem cells (ESCs) are pluripotent stem cells and can form tumors containing cells from all three germ layers. Similarities between pluripotent stem cells and malignant tumor cells have been identifie...

    Authors: Xinrong Peng, Tao Liu, Ying Wang, Qiaoling Yan, Huajun Jin, Linfang Li, Qijun Qian and Mengchao Wu

    Citation: Journal of Translational Medicine 2012 10:196

    Content type: Research

    Published on:

  46. Adipose tissue is an attractive source of cells for therapeutic purposes because of the ease of harvest and the high frequency of mesenchymal stem cells (MSCs). Whilst it is clear that MSCs have significant th...

    Authors: Sinead P Blaber, Rebecca A Webster, Cameron J Hill, Edmond J Breen, Donald Kuah, Graham Vesey and Benjamin R Herbert

    Citation: Journal of Translational Medicine 2012 10:172

    Content type: Research

    Published on:

  47. During wound healing processes fibroblasts account for wound closure by adopting a contractile phenotype. One disease manifestation of COPD is emphysema which is characterized by destruction of alveolar walls ...

    Authors: Oskar Hallgren, Sara Rolandsson, Annika Andersson-Sjöland, Kristian Nihlberg, Elisabet Wieslander, Martina Kvist-Reimer, Magnus Dahlbäck, Leif Eriksson, Leif Bjermer, Jonas S Erjefält, Claes-Göran Löfdahl and Gunilla Westergren-Thorsson

    Citation: Journal of Translational Medicine 2012 10:171

    Content type: Research

    Published on:

  48. Interferon regulatory factor (IRF)-5 is a transcription factor involved in type I interferon signaling whose germ line variants have been associated with autoimmune pathogenesis. Since relationships have been obs...

    Authors: Lorenzo Uccellini, Valeria De Giorgi, Yingdong Zhao, Barbara Tumaini, Narnygerel Erdenebileg, Mark E Dudley, Sara Tomei, Davide Bedognetti, Maria Libera Ascierto, Qiuzhen Liu, Richard Simon, Leah Kottyan, Kenneth M Kaufman, John B Harley, Ena Wang, Steven A Rosenberg…

    Citation: Journal of Translational Medicine 2012 10:170

    Content type: Research

    Published on:

  49. Overexpression of GOLPH3 (Golgi phosphoprotein 3, 34 kDa) is associated with the progression of many solid tumor types leading to an unfavorable clinical outcome. We aimed to investigate the clinical significa...

    Authors: Huan Li, Ling Guo, Shu-Wei Chen, Xiao-Hui Zhao, Shi-Min Zhuang, Li-Ping Wang, Li-Bing Song and Ming Song

    Citation: Journal of Translational Medicine 2012 10:168

    Content type: Research

    Published on:

  50. Recent data suggest that cancer stem cells (CSCs) play an important role in cancer, as these cells possess enhanced tumor-forming capabilities and are responsible for relapses after apparently curative therapi...

    Authors: Huiqiang Wang, Nanhai G Chen, Boris R Minev and Aladar A Szalay

    Citation: Journal of Translational Medicine 2012 10:167

    Content type: Research

    Published on:

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