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Cell, Tissue and Gene Therapy

Section edited by David Stroncek

This section aims to improve communication between basic and clinical research related to cell, tissue and gene therapies. Effective clinical therapies require efficient translation of research between the bench and bedside to allow the discovery, development, scale up, and production of cells, tissues and vectors. These therapies are being used to treat patients with a range of diseases including cancer, cardiovascular diseases, autoimmune disorders.

Studies considered for publication include those regarding the nature of cells, tissues and vectors used in clinical therapies; methods to collect, isolate and modify cells; and novel reagents, equipment, and instruments used in production. The section also welcomes research into the application of clinical therapies; factors that effect the safety and efficacy; in particular the potency, stability and purity of cells or tissue; and issues related to the safety of cell and tissue donors.

Featured articles

Phase I and registry study of autologous bone marrow concentrate evaluated in PDE5 inhibitor refractory erectile dysfunction

Research | Mark Bieri et al


Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients​​​​​​​

Review | Christopher J. Rogers et al


Allo-priming as a universal anti-viral vaccine: protecting elderly from current COVID-19 and any future unknown viral outbreak

Review |  Michael Har-Noy & Reuven Or 

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  1. Interferon gamma (IFNγ) plays an important role in the development of chronic lung diseases via the production of inflammatory mediators, although the exact mechanism remains unclear. The present study aimed a...

    Authors: Yichun Zhu, Dongli Song, Yuanlin Song and Xiangdong Wang
    Citation: Journal of Translational Medicine 2019 17:147
  2. The role of γδ T cells, innate-like lymphocytes with unrestrained MHC, in various malignancies has recently been extensively studied. However, there is limited research regarding γδ T cells in ovarian cancer (...

    Authors: Xian Chen, Wenwen Shang, Rui Xu, Ming Wu, Xiaojie Zhang, Peijun Huang, Fang Wang and Shiyang Pan
    Citation: Journal of Translational Medicine 2019 17:144
  3. Mitochondria take part in a network of cellular processes that regulate cell homeostasis. Defects in mitochondrial function are key pathophysiological changes during acute kidney injury (AKI). Mesenchymal stem...

    Authors: Lingfei Zhao, Chenxia Hu, Ping Zhang, Hua Jiang and Jianghua Chen
    Citation: Journal of Translational Medicine 2019 17:142
  4. Cell based therapies, such as bone marrow derived mesenchymal stem cells (BM-MSCs; also known as mesenchymal stromal cells), are currently under investigation for a number of disease applications. The current ...

    Authors: Alpa Trivedi, Byron Miyazawa, Stuart Gibb, Kristen Valanoski, Lindsay Vivona, Maximillian Lin, Daniel Potter, Mars Stone, Philip J. Norris, James Murphy, Sawyer Smith, Martin Schreiber and Shibani Pati
    Citation: Journal of Translational Medicine 2019 17:128
  5. Cancer is a serious health issue in the world due to a large body of cancer-related human deaths, and there is no current treatment available to efficiently treat the disease as the tumor is often diagnosed at...

    Authors: Yanyan Han
    Citation: Journal of Translational Medicine 2019 17:116
  6. The number of Mesenchymal Stem/Stromal Cells (MSCs) in the human bone marrow (BM) is small compared to other cell types. BM aspirate concentration (BMAC) may be used to increase numbers of MSCs, but the compos...

    Authors: Richard Schäfer, Malcolm R. DeBaun, Erika Fleck, Christopher J. Centeno, Daniela Kraft, Johannes Leibacher, Karen Bieback, Erhard Seifried and Jason L. Dragoo
    Citation: Journal of Translational Medicine 2019 17:115
  7. Monoallelic expression (MAE) is a frequent genomic phenomenon in normal tissues, however its role in cancer is yet to be fully understood. MAE is defined as the expression of a gene that is restricted to one a...

    Authors: Lee Silcock, Hakeem Almabrazi, Younes Mokrab, Puthen Jithesh, Muna Al-Hashmi, Nicola James, Rebecca Mathew, Valentina Mattei, Davide Bedognetti, Francesca Lessi, Ramzi Temanni, Barbara Seliger, Rashid Al-Ali, Francesco M. Marincola, Ena Wang and Sara Tomei
    Citation: Journal of Translational Medicine 2019 17:112
  8. A stroke caused by angiostenosis always has a poor prognosis. Bone marrow stromal cells (BMSC) are widely applied in vascular regeneration. Recently, thrombospondin-4 (TSP4) was reported to promote the regener...

    Authors: Qian Zhang, Meiling Zhou, Xiangfeng Wu, Zhu Li, Bing Liu, Wenbin Gao, Jin Yue and Tao Liu
    Citation: Journal of Translational Medicine 2019 17:111
  9. Bone marrow-derived stem cells (BMSCs) and chondrocytes have been reported to present “dedifferentiation” and “phenotypic loss” during the chondrogenic differentiation process in cartilage tissue engineering, ...

    Authors: Ke Xue, Xiaodie Zhang, Zixu Gao, Wanyao Xia, Lin Qi and Kai Liu
    Citation: Journal of Translational Medicine 2019 17:104
  10. Monocytes are myeloid cells that reside in the blood and bone marrow and respond to inflammation. At the site of inflammation, monocytes express cytokines and chemokines. Monocytes have been shown to be cytoto...

    Authors: Daniel S. Green, Ana T. Nunes, Kevin W. Tosh, Virginia David-Ocampo, Vicki S. Fellowes, Jiaqiang Ren, Jianjian Jin, Sue-Ellen Frodigh, Chauha Pham, Jolynn Procter, Celina Tran, Irene Ekwede, Hanh Khuu, David F. Stroncek, Steven L. Highfill, Kathryn C. Zoon…
    Citation: Journal of Translational Medicine 2019 17:82
  11. Mesenchymal stromal cells (MSCs) were originally characterized by the ability to differentiate into different mesenchymal lineages in vitro, and their immunomodulatory and trophic functions have recently arous...

    Authors: Ya-nan Bie, Peng Gu, Yu-ting Chen, Xiao-xu Zhou, Yu-guang Tian, Qin Yang, Hai-yan Li, Xia Lin, Yan-hong Guan, Tao-yan Lin, Xun Lu, Hong-fen Shen, Ting-xiao Fang, Yu-min Liu, Dong Xiao and Wei-Wang Gu
    Citation: Journal of Translational Medicine 2019 17:72
  12. Human amniotic fluid (AF) contains numerous nutrients, trophic factors and defense proteins that provide a nurturing and protective environment for fetal development. Based on reports that AF has antibacterial...

    Authors: Yong Mao, Jan Pierce, Anya Singh-Varma, Michael Boyer, Joachim Kohn and Jo-Anna Reems
    Citation: Journal of Translational Medicine 2019 17:68
  13. As the optimal source of seed cells in periodontal tissue engineering, periodontal ligament stem cells (PDLSCs) have always been researched to improve cell expansion due to their limited resource and spontaneo...

    Authors: Chunshu Zhang, Hongmei Guo, Chengzhe Yang, Qian Chen, Jiahui Huang, Lianlian Liu, Yu Zhang, Shanshan Jin, Aimei Song and Pishan Yang
    Citation: Journal of Translational Medicine 2019 17:66
  14. Bone marrow stromal cells (BMSCs) are a heterogeneous population that participates in wound healing, immune modulation and tissue regeneration. Next generation sequencing was used to analyze transcripts from s...

    Authors: Shutong Liu, David F. Stroncek, Yingdong Zhao, Victoria Chen, Rongye Shi, Jinguo Chen, Jiaqiang Ren, Hui Liu, Hee Joon Bae, Steven L. Highfill and Ping Jin
    Citation: Journal of Translational Medicine 2019 17:23
  15. This study examined the quality of bone marrow aspirates extracted using a novel, FDA cleared method to optimally target cells from the inner cortical iliac bone surface without the need for centrifugation. Th...

    Authors: Michael Scarpone, Daniel Kuebler, Andrew Chambers, Carlo Maria De Filippo, Mariangela Amatuzio, Thomas E. Ichim, Amit N. Patel and Eugenio Caradonna
    Citation: Journal of Translational Medicine 2019 17:10
  16. Cell-based therapies have shown promise for the treatment of knee osteoarthritis (OA). The current study compared exercise therapy to autologous bone marrow concentrate (BMC) and platelet products for knee OA ...

    Authors: Christopher Centeno, Mitchell Sheinkop, Ehren Dodson, Ian Stemper, Christopher Williams, Matthew Hyzy, Thomas Ichim and Michael Freeman
    Citation: Journal of Translational Medicine 2018 16:355
  17. Adipose-derived mesenchymal stem cell (ADMSC) therapy can promote recovery from cerebral ischemia; however, more information regarding appropriate sources of ADMSCs is required. This study was aimed at analyzi...

    Authors: Zhang Yu, Tang Wenyan, Su Xuewen, Dong Baixiang, Wang Qian, Wang Zhaoyan, Yang Yinxiang, Qu Suqing and Luan Zuo
    Citation: Journal of Translational Medicine 2018 16:339
  18. At present, many laboratories and hospitals all over the world are attempting and exploring the clinical transformation of this tissue engineered bone graft (TEBG) strategy. Many successful cases of bone tissu...

    Authors: Dingyu Wu, Zhenxing Wang, Zhiwei Zheng, Yingnan Geng, Zhanzhao Zhang, Qiannan Li, Quan Zhou, Yilin Cao and Zhi-Yong Zhang
    Citation: Journal of Translational Medicine 2018 16:324
  19. Bone is a highly vascularized and resilient organ with innate healing abilities, however some bone injuries overwhelm these attributes and require intervention, such as bone tissue engineering strategies. Comb...

    Authors: Emily L. Durham, R. Nicole Howie, SarahRose Hall, Nicholas Larson, Brayden Oakes, Reed Houck, Zachary Grey, Martin Steed, Amanda C. LaRue, Robin Muise-Helmericks and James Cray
    Citation: Journal of Translational Medicine 2018 16:321
  20. Successful delivery of cell-based therapeutics into patients is compromised by their short shelf-life upon release from production facilities due to the living nature of the active component that rapidly loses...

    Authors: Clémentine Mirabel, Eduard Puente-Massaguer, Anna del Mazo-Barbara, Blanca Reyes, Philip Morton, Francesc Gòdia and Joaquim Vives
    Citation: Journal of Translational Medicine 2018 16:291
  21. Cardiomyocytes derived from animals and induced pluripotent stem cells (iPSCs) are two main cellular models to study cardiovascular diseases, however, neither provides precise modeling of the response of matur...

    Authors: Guang-ran Guo, Liang Chen, Man Rao, Kai Chen, Jiang-ping Song and Sheng-shou Hu
    Citation: Journal of Translational Medicine 2018 16:288
  22. New technologies and therapies designed to facilitate development of personalized treatments are rapidly emerging in the field of biomedicine. Strikingly, the goal of personalized medicine refined the concept ...

    Authors: Sara Deola, Bella S. Guerrouahen, Heba Sidahmed, Anjud Al-Mohannadi, Muhammad Elnaggar, Ramaz Elsadig, Essam M. Abdelalim, Goran Petrovski, Massimo Gadina, Adrian Thrasher, Winfried S. Wels, Stephen P. Hunger, Ena Wang, Francesco M. Marincola, Cristina Maccalli and Chiara Cugno
    Citation: Journal of Translational Medicine 2018 16:276
  23. Bone marrow concentrate (BMC) has shown promise in the treatment of several orthopedic conditions. This registry study investigated the use of autologous BMC and platelet products for percutaneous anterior cru...

    Authors: Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Christopher Williams, Matthew Hyzy, Thomas Ichim and Michael Freeman
    Citation: Journal of Translational Medicine 2018 16:246
  24. Tumor necrosis factor (TNF)-alpha was originally identified in the 1970s as the serum mediator of innate immunity capable of inducing hemorrhagic necrosis in tumors. Today, a wide spectrum of biological activi...

    Authors: Steven F. Josephs, Thomas E. Ichim, Stephen M. Prince, Santosh Kesari, Francesco M. Marincola, Anton Rolando Escobedo and Amir Jafri
    Citation: Journal of Translational Medicine 2018 16:242
  25. Mesenchymal stem cells (MSCs) represent an attractive avenue for cellular therapies targeting degenerative diseases. MSC in vitro expansion is required in order to obtain therapeutic numbers during the manufac...

    Authors: C. Elabd, T. E. Ichim, K. Miller, A. Anneling, V. Grinstein, V. Vargas and F. J. Silva
    Citation: Journal of Translational Medicine 2018 16:222
  26. Mesenchymal stromal cells (MSCs) are a promising option to treat knee osteoarthritis (OA). Their safety and usefulness have been reported in several short-term clinical trials but less information is available...

    Authors: José María Lamo-Espinosa, Gonzalo Mora, Juan F. Blanco, Froilán Granero-Moltó, Jorge María Núñez-Córdoba, Silvia López-Elío, Enrique Andreu, Fermín Sánchez-Guijo, José Dámaso Aquerreta, José María Bondía, Andrés Valentí-Azcárate, María del Consuelo del Cañizo, Eva María Villarón, Juan Ramón Valentí-Nin and Felipe Prósper
    Citation: Journal of Translational Medicine 2018 16:213
  27. Mesenchymal stem cell (MSC) therapy offers great potential for treatment of disease through the multifunctional and responsive ability of these cells. In numerous contexts, MSC have been shown to reduce inflam...

    Authors: Thomas E. Ichim, Pete O’Heeron and Santosh Kesari
    Citation: Journal of Translational Medicine 2018 16:212
  28. Necroptotic susceptibility is probably an intrinsic weakness of cancer. Here, we report that resibufogenin, a member of bufadienolide family, suppresses the growth and metastasis of colorectal cancer (CRC) thr...

    Authors: Qinrui Han, Ye Ma, Hao Wang, Yu Dai, Chunhui Chen, Yawei Liu, Linlin Jing and Xuegang Sun
    Citation: Journal of Translational Medicine 2018 16:201
  29. Stored platelets undergo deleterious changes, referred to as platelet storage lesions (PSLs), which accelerate the desialylation of platelets and result in their phagocytosis and clearance by hepatic macrophag...

    Authors: Jooyoung Cho, Hyunkyung Kim, Jaewoo Song, June-Won Cheong, Jeong Won Shin, Woo Ick Yang and Hyun Ok Kim
    Citation: Journal of Translational Medicine 2018 16:199
  30. Spinal cord injury (SCI) is one of the most severe central nervous system injuries. Currently, transplanting bone marrow mesenchymal stem cells (BMSCs) is considered a therapeutic option for SCI. Tanshinone II...

    Authors: Xue-Mei Zhang, Jiao Ma, Yang Sun, Bing-Qian Yu, Zhuo-Min Jiao, Duo Wang, Mei-Yu Yu, Jin-Yue Li and Jin Fu
    Citation: Journal of Translational Medicine 2018 16:193
  31. To explore the mechanism of the different clinical efficacies of mesenchymal stem cell transplantation (MSCT) and identify a possible serum biomarker for predicting the therapeutic effect of MSCT in rheumatoid...

    Authors: Yi Yang, Xiao He, Rongseng Zhao, Wei Guo, Ming Zhu, Wei Xing, Dongpo Jiang, Chongyang Liu and Xiang Xu
    Citation: Journal of Translational Medicine 2018 16:165

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:402

  32. The reconstruction of bone defects is often impaired by radiotherapy since bone quality is compromised by radiation. This study aims to investigate the therapeutic efficacy of the composite cell sheets-bone ma...

    Authors: Huan Liu, Yang Jiao, Wei Zhou, Shizhu Bai, Zhihong Feng, Yan Dong, Qian Liu, Xiaoke Feng and Yimin Zhao
    Citation: Journal of Translational Medicine 2018 16:137
  33. Cell homing is the mechanism by which an injury releases signaling molecules that cause recruitment, proliferation, migration and differentiation of progenitor cells. Stromal derived factor-1 (SDF-1) and its r...

    Authors: Melissa Kristocheck, Lucinara D. Dias, Carine Ghem, Bruna Eibel, Renato A. K. Kalil and Melissa M. Markoski
    Citation: Journal of Translational Medicine 2018 16:133
  34. Stem cell therapy has been applied in the treatment of acute-on-chronic liver failure (ACLF). However, its clinical efficiency is still debatable. The aim of this systematic review and meta-analysis is to eval...

    Authors: Ran Xue, Qinghua Meng, Jinling Dong, Juan Li, Qinwei Yao, Yueke Zhu and Hongwei Yu
    Citation: Journal of Translational Medicine 2018 16:126
  35. A major complication after allogeneic hematopoietic stem cell transplantation (aSCT) is the reactivation of herpesviruses such as cytomegalovirus (CMV) and Epstein–Barr virus (EBV). Both viruses cause signific...

    Authors: Regina Gary, Michael Aigner, Stephanie Moi, Stefanie Schaffer, Anja Gottmann, Stefanie Maas, Robert Zimmermann, Jürgen Zingsem, Julian Strobel, Andreas Mackensen, Josef Mautner, Andreas Moosmann and Armin Gerbitz
    Citation: Journal of Translational Medicine 2018 16:124
  36. The role of rabbit synovial fluid-derived mesenchymal stem cells (rbSF-MSCs) in cartilage defect repair remains undefined. This work evaluates the in vivo effects of rbSF-MSCs to repair knee articular cartilag...

    Authors: Zhaofeng Jia, Qisong Liu, Yujie Liang, Xingfu Li, Xiao Xu, Kan Ouyang, Jianyi Xiong, Daping Wang and Li Duan
    Citation: Journal of Translational Medicine 2018 16:123
  37. Pancreatic ductal adenocarcinoma (PDAC) has been increasing by 0.5% per year in the United States. PDAC portends a dismal prognosis and novel therapies are needed. This study describes the generation and chara...

    Authors: Michael P. O’Leary, Audrey H. Choi, Sang-In Kim, Shyambabu Chaurasiya, Jianming Lu, Anthony K. Park, Yanghee Woo, Susanne G. Warner, Yuman Fong and Nanhai G. Chen
    Citation: Journal of Translational Medicine 2018 16:110
  38. Saethre–Chotzen syndrome is an autosomal dominantly inherited disorder caused by mutations in the twist family basic helix-loop-helix transcription factor 1 (TWIST1) gene. Surgical procedures are frequently re...

    Authors: Shanshan Bai, Dong Li, Liang Xu, Huichuan Duan, Jie Yuan and Min Wei
    Citation: Journal of Translational Medicine 2018 16:103
  39. Radiation-induced lung toxicity (RILT) is a severe complication of radiotherapy in patients with thoracic tumors. Through proteomics, we have previously identified vitronectin (VTN) as a potential biomarker fo...

    Authors: Tian-Le Shen, Mi-Na Liu, Qin Zhang, Wen Feng, Wen Yu, Xiao-Long Fu and Xu-Wei Cai
    Citation: Journal of Translational Medicine 2018 16:100
  40. Members in Motin family, or Angiomotins (AMOTs), are adaptor proteins that localize in the membranous, cytoplasmic or nuclear fraction in a cell context-dependent manner. They control the bioprocesses such as ...

    Authors: Tingting Huang, Yuhang Zhou, Jinglin Zhang, Alfred S. L. Cheng, Jun Yu, Ka Fai To and Wei Kang
    Citation: Journal of Translational Medicine 2018 16:98
  41. Bone marrow stromal cells (BMSCs) have classically been cultured in media supplemented with fetal bovine serum (FBS). As an alternative to FBS, pooled solvent detergent apheresis platelets, HPGF-C18, was evalu...

    Authors: Jiaqiang Ren, Dawn Ward, Steven Chen, Katherine Tran, Ping Jin, Marianna Sabatino, Pamela G. Robey and David F. Stroncek
    Citation: Journal of Translational Medicine 2018 16:65
  42. Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly characterized by retinal pigment epithelium (RPE) degeneration with accumulation of abnormal intracellular deposits (lip...

    Authors: George Inana, Christopher Murat, Weijun An, Xiang Yao, Ian R. Harris and Jing Cao
    Citation: Journal of Translational Medicine 2018 16:63
  43. Multiple sclerosis (MS) is a progressively debilitating neurological condition in which the immune system abnormally erodes the myelin sheath insulating the nerves. Mesenchymal stem cells (MSC) have been used ...

    Authors: Neil H. Riordan, Isabela Morales, Giselle Fernández, Nicole Allen, Neal E. Fearnot, Michael E. Leckrone, Dedra Jones Markovich, Darla Mansfield, Dorita Avila, Amit N. Patel, Santosh Kesari and Jorge Paz Rodriguez
    Citation: Journal of Translational Medicine 2018 16:57

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:197

  44. Kidneys from deceased donors are being used to meet the growing need for grafts. However, delayed graft function (DGF) and acute rejection incidences are high, leading to adverse effects on graft outcomes. Opt...

    Authors: Qipeng Sun, Zhengyu Huang, Fei Han, Ming Zhao, Ronghua Cao, Daqiang Zhao, Liangqing Hong, Ning Na, Heng Li, Bin Miao, Jianmin Hu, Fanhang Meng, Yanwen Peng and Qiquan Sun
    Citation: Journal of Translational Medicine 2018 16:52
  45. Cell therapies are being investigated as potential disease modifying treatment options for osteoarthritis (OA). Progenza (PRG) comprises in vitro expanded mesenchymal stem cells derived from human donor adipos...

    Authors: D. Kuah, S. Sivell, T. Longworth, K. James, A. Guermazi, F. Cicuttini, Y. Wang, S. Craig, G. Comin, D. Robinson and J. Wilson
    Citation: Journal of Translational Medicine 2018 16:49
  46. The role of transforming growth factorβ (TGF-β)-induced tumor progression in advanced malignancy is well established, but the involvement of long non-coding RNAs (lncRNAs) in TGF-β signaling remains unclear. T...

    Authors: Teng Huang, Wei Huang, Hong Lu, Bi-yun Zhang, Jun Ma, Di Zhao, Yi-jun Wang, Da-hai Yu and Xia He
    Citation: Journal of Translational Medicine 2018 16:46
  47. Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE)...

    Authors: Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang Wang and Chunmao Han
    Citation: Journal of Translational Medicine 2018 16:29
  48. We have recently shown that memory B cells from murine CMV immune donor animals adoptively transferred into immunodeficient mice were highly effective in protecting from a viral infection indicating a therapeu...

    Authors: Hannes Tittlbach, Andrea Schneider, Julian Strobel, Robert Zimmermann, Stefanie Maas, Bernd Gebhardt, Georg Rauser, Michael Mach, Andreas Mackensen, Thomas H. Winkler and Julia Winkler
    Citation: Journal of Translational Medicine 2017 15:228

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