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Cell, tissue and gene therapy

Section edited by David Stroncek

This section aims to improve communication between basic and clinical research related to cell, tissue and gene therapies. Effective clinical therapies require efficient translation of research between the bench and bedside to allow the discovery, development, scale up, and production of cells, tissues and vectors. These therapies are being used to treat patients with a range of diseases including cancer, cardiovascular diseases, autoimmune disorders.

Studies considered for publication include those regarding the nature of cells, tissues and vectors used in clinical therapies; methods to collect, isolate and modify cells; and novel reagents, equipment, and instruments used in production. The section also welcomes research into the application of clinical therapies; factors that effect the safety and efficacy; in particular the potency, stability and purity of cells or tissue; and issues related to the safety of cell and tissue donors.

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  1. Content type: Research

    The discovery of mesenchymal stem cells (MSCs) or MSC-like cells in cartilage tissue does not tie in well with the established view that MSCs derive from a perivascular niche. The presence of MSCs may raise co...

    Authors: Karin Benz, Claudia Stippich, Christian Freudigmann, Juergen A Mollenhauer and Wilhelm K Aicher

    Citation: Journal of Translational Medicine 2013 11:27

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  2. Content type: Research

    Linker for activation of T cells (LAT), a transmembrane adaptor protein, plays a role in T cell and mast cell function, while it remains unclear how histone modifications mediate LAT expression in allergic ast...

    Authors: Cheng-ye Li, Juan Peng, Lian-pin Ren, Li-xing Gan, Xiao-jiong Lu, Qian Liu, Wen Gu and Xue-jun Guo

    Citation: Journal of Translational Medicine 2013 11:26

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  3. Content type: Research

    Kidneys derived from brain dead donors have lower graft survival and higher graft-function loss compared to their living donor counterpart. Heat Shock Proteins (HSP) are a large family of stress proteins invol...

    Authors: Leon FA van Dullemen, Eelke M Bos, Theo A Schuurs, Harm H Kampinga, Rutger J Ploeg, Harry van Goor and Henri GD Leuvenink

    Citation: Journal of Translational Medicine 2013 11:22

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  4. Content type: Research

    Stem cell therapy is a promising treatment for cerebral palsy, which refers to a category of brain diseases that are associated with chronic motor disability in children. Autologous MSCs may be a better cell s...

    Authors: Guojun Chen, Yali Wang, Zhenyu Xu, Feng Fang, Renmei Xu, Yue Wang, Xiaoli Hu, Lixing Fan and Houqi Liu

    Citation: Journal of Translational Medicine 2013 11:21

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  5. Content type: Research

    Mesenchymal stem cells (MSC) can serve as carriers to deliver oncolytic measles virus (MV) to ovarian tumors. In preparation for a clinical trial to use MSC as MV carriers, we obtained cells from ovarian cance...

    Authors: Emily K Mader, Greg Butler, Sean C Dowdy, Andrea Mariani, Keith L Knutson, Mark J Federspiel, Stephen J Russell, Evanthia Galanis, Allan B Dietz and Kah-Whye Peng

    Citation: Journal of Translational Medicine 2013 11:20

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  6. Content type: Research

    ECBio has developed proprietary technology to consistently isolate, expand and cryopreserve a well-characterized population of stromal cells from human umbilical cord tissue (UCX® cells). The technology has re...

    Authors: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz and Helder Cruz

    Citation: Journal of Translational Medicine 2013 11:18

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  7. Content type: Research

    Pharmacologic reactivation of fetal hemoglobin expression is a promising strategy for treatment of sickle cell disease and β-thalassemia. The objective of this study was to investigate the effect of the methyl...

    Authors: Yinghong He, Gerhard Rank, Miaomiao Zhang, Junyi Ju, Ronghua Liu, Zhen Xu, Fiona Brown, Loretta Cerruti, Chi Ma, Renxiang Tan, Stephen M Jane and Quan Zhao

    Citation: Journal of Translational Medicine 2013 11:14

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  8. Content type: Research

    Interferon-γ (IFN-γ) is regarded as a potent antitumor agent, but its clinical application is limited by its short half-life and significant side effects. In this paper, we tried to develop IFN-γ gene therapy ...

    Authors: Ran-yi Liu, Ying-hui Zhu, Ling Zhou, Peng Zhao, Hong-li Li, Lan-cai Zhu, Hong-yu Han, Huan-xin Lin, Liang Kang, Jiang-xue Wu and Wenlin Huang

    Citation: Journal of Translational Medicine 2012 10:256

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  9. Content type: Research

    We tested whether apoptotic adipose-derived mesenchymal stem cells (A-ADMSCs) were superior to healthy (H)-ADMSCs at attenuating organ damage and mortality in sepsis syndrome following cecal ligation and punct...

    Authors: Chia-Lo Chang, Steve Leu, Hsin-Ching Sung, Yen-Yi Zhen, Chung-Lung Cho, Angela Chen, Tzu-Hsien Tsai, Sheng-Ying Chung, Han-Tan Chai, Cheuk-Kwan Sun, Chia-Hung Yen and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2012 10:244

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  10. Content type: Research

    Ischemia is the major cause of acute kidney injury (AKI), associated with high mortality and morbidity. Mesenchymal stem cells (MSCs) have multilineage differentiation potential and can be a potent therapeutic...

    Authors: Muhammad Shareef Masoud, Sanam Saiqa Anwar, Muhammad Zeeshan Afzal, Azra Mehmood, Shaheen N Khan and Sheikh Riazuddin

    Citation: Journal of Translational Medicine 2012 10:243

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  11. Content type: Research

    The secretory small GTPase Rab27b was recently identified as an oncogene in breast cancer (BC) in vivo and in vitro studies. This research was designed to further explore the clinical and prognostic significan...

    Authors: Jia-Xing Zhang, Xiao-Xia Huang, Man-Bo Cai, Zhu-Ting Tong, Jie-Wei Chen, Dong Qian, Yi-Ji Liao, Hai-Xia Deng, Ding-Zhun Liao, Ma-Yan Huang, Yi-Xin Zeng, Dan Xie and Shi-Juan Mai

    Citation: Journal of Translational Medicine 2012 10:242

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  12. Content type: Review

    The use of large animals as an experimental model for novel treatment techniques has many advantages over the use of laboratory animals, so veterinary medicine is becoming an increasingly important translation...

    Authors: Darja Pavlin, Maja Cemazar, Gregor Sersa and Natasa Tozon

    Citation: Journal of Translational Medicine 2012 10:234

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  13. Content type: Research

    Machine perfusion (MP) of kidney graft provides benefits against preservation injury, however decreased graft quality requires optimization of the method. We examined the chronic benefits of MP on kidney graft...

    Authors: Raphael Thuillier, Ricardo Codas, Etienne Marchand, Hubert Lathelize, Olivier Page, Alexandre Valagier, Lionel Badet and Thierry Hauet

    Citation: Journal of Translational Medicine 2012 10:233

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  14. Content type: Review

    Despite the successes of recombinant hematopoietic-stimulatory factors at accelerating bone marrow reconstitution and shortening the neutropenic period post-transplantation, significant challenges remain such ...

    Authors: J Christopher Mizer, Thomas E Ichim, Doru T Alexandrescu, Constantin A Dasanu, Famela Ramos, Andrew Turner, Erik J Woods, Vladimir Bogin, Michael P Murphy, David Koos and Amit N Patel

    Citation: Journal of Translational Medicine 2012 10:231

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  15. Content type: Research

    Numerous preclinical and clinical studies have investigated the regenerative potential and the trophic support of mesenchymal stem cells (MSCs) following their injection into a target organ. Clinicians favor t...

    Authors: Murali Krishna Mamidi, Gurbind Singh, Juani Mazmin Husin, Kavitha Ganesan Nathan, Gopinath Sasidharan, Zubaidah Zakaria, Ramesh Bhonde, Anish Sen Majumdar and Anjan Kumar Das

    Citation: Journal of Translational Medicine 2012 10:229

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  16. Content type: Research

    GADD45B is a member of the growth arrest DNA damage-inducible gene family associated with cell growth control, apoptosis, and DNA damage repair response. The aim of this study is to detect the role of GADD45B ...

    Authors: Lisha Wang, Xiuying Xiao, Dali Li, Yayun Chi, Ping Wei, Yiqin Wang, Shujuan Ni, Cong Tan, Xiaoyan Zhou and Xiang Du

    Citation: Journal of Translational Medicine 2012 10:215

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  17. Content type: Research

    Inactivaion of tumor suppressor genes (TSGs) by promoter CpG methylation frequently occurs in tumorigenesis, even in the early stages, contributing to the initiation and progression of human cancers. Deleted in l...

    Authors: Zhaohui Wang, Lili Li, Xianwei Su, Zifen Gao, Gopesh Srivastava, Paul G Murray, Richard Ambinder and Qian Tao

    Citation: Journal of Translational Medicine 2012 10:209

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  18. Content type: Research

    Endometrial regenerative cells (ERC) and bone marrow stromal cells (BMSC) are being used in clinical trials. While they have been reported to have similar characteristics, they have not been directly compared.

    Authors: Huan Wang, Ping Jin, Marianna Sabatino, Jiaqiang Ren, Sara Civini, Vladimir Bogin, Thomas E Ichim and David F Stroncek

    Citation: Journal of Translational Medicine 2012 10:207

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  19. Content type: Research

    Fork head box M1 (FoxM1) is a proliferation-associated transcription factor essential for cell cycle progression. Numerous studies have documented that FoxM1 has multiple functions in tumorigenesis and its ele...

    Authors: Yi-Jun Xue, Ri-Hai Xiao, Da-Zhi Long, Xiao-Feng Zou, Xiao-Ning Wang, Guo-Xi Zhang, Yuan-Hu Yuan, Geng-Qing Wu, Jun Yang, Yu-Ting Wu, Hui Xu, Fo-Lin Liu and Min Liu

    Citation: Journal of Translational Medicine 2012 10:200

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  20. Content type: Research

    Embryonic stem cells (ESCs) are pluripotent stem cells and can form tumors containing cells from all three germ layers. Similarities between pluripotent stem cells and malignant tumor cells have been identifie...

    Authors: Xinrong Peng, Tao Liu, Ying Wang, Qiaoling Yan, Huajun Jin, Linfang Li, Qijun Qian and Mengchao Wu

    Citation: Journal of Translational Medicine 2012 10:196

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  21. Content type: Research

    Adipose tissue is an attractive source of cells for therapeutic purposes because of the ease of harvest and the high frequency of mesenchymal stem cells (MSCs). Whilst it is clear that MSCs have significant th...

    Authors: Sinead P Blaber, Rebecca A Webster, Cameron J Hill, Edmond J Breen, Donald Kuah, Graham Vesey and Benjamin R Herbert

    Citation: Journal of Translational Medicine 2012 10:172

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  22. Content type: Research

    During wound healing processes fibroblasts account for wound closure by adopting a contractile phenotype. One disease manifestation of COPD is emphysema which is characterized by destruction of alveolar walls ...

    Authors: Oskar Hallgren, Sara Rolandsson, Annika Andersson-Sjöland, Kristian Nihlberg, Elisabet Wieslander, Martina Kvist-Reimer, Magnus Dahlbäck, Leif Eriksson, Leif Bjermer, Jonas S Erjefält, Claes-Göran Löfdahl and Gunilla Westergren-Thorsson

    Citation: Journal of Translational Medicine 2012 10:171

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  23. Content type: Research

    Interferon regulatory factor (IRF)-5 is a transcription factor involved in type I interferon signaling whose germ line variants have been associated with autoimmune pathogenesis. Since relationships have been obs...

    Authors: Lorenzo Uccellini, Valeria De Giorgi, Yingdong Zhao, Barbara Tumaini, Narnygerel Erdenebileg, Mark E Dudley, Sara Tomei, Davide Bedognetti, Maria Libera Ascierto, Qiuzhen Liu, Richard Simon, Leah Kottyan, Kenneth M Kaufman, John B Harley, Ena Wang, Steven A Rosenberg…

    Citation: Journal of Translational Medicine 2012 10:170

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  24. Content type: Research

    Overexpression of GOLPH3 (Golgi phosphoprotein 3, 34 kDa) is associated with the progression of many solid tumor types leading to an unfavorable clinical outcome. We aimed to investigate the clinical significa...

    Authors: Huan Li, Ling Guo, Shu-Wei Chen, Xiao-Hui Zhao, Shi-Min Zhuang, Li-Ping Wang, Li-Bing Song and Ming Song

    Citation: Journal of Translational Medicine 2012 10:168

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  25. Content type: Research

    Recent data suggest that cancer stem cells (CSCs) play an important role in cancer, as these cells possess enhanced tumor-forming capabilities and are responsible for relapses after apparently curative therapi...

    Authors: Huiqiang Wang, Nanhai G Chen, Boris R Minev and Aladar A Szalay

    Citation: Journal of Translational Medicine 2012 10:167

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  26. Content type: Research

    Mucopolysaccharidoses (MPS) are severe metabolic disorders caused by accumulation of undegraded glycosaminoglycans (GAGs) in lysosomes due to defects in certain lysosomal hydrolases. Substrate reduction therap...

    Authors: Anna Kloska, Magdalena Narajczyk, Joanna Jakóbkiewicz-Banecka, Grzegorz Grynkiewicz, Wiesław Szeja, Magdalena Gabig-Cimińska and Grzegorz Węgrzyn

    Citation: Journal of Translational Medicine 2012 10:153

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  27. Content type: Research

    Special AT-rich sequence-binding protein-1 (SATB1) has been reported to be expressed in several human cancers and may have malignant potential. This study was aimed at investigating the expression and potentia...

    Authors: Sheng-Hua Chu, Yan-Bin Ma, Dong-Fu Feng, Hong Zhang, Zhi-An Zhu, Zhi-Qiang Li and Pu-Cha Jiang

    Citation: Journal of Translational Medicine 2012 10:149

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  28. Content type: Research

    Aptamer-based tumor targeted drug delivery system is a promising approach that may increase the efficacy of chemotherapy and reduce the related toxicity. HER2 protein is an attractive target for tumor-specific...

    Authors: Zhe Liu, Jin-Hong Duan, Yong-Mei Song, Jie Ma, Feng-Dan Wang, Xin Lu and Xian-Da Yang

    Citation: Journal of Translational Medicine 2012 10:148

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  29. Content type: Research

    Bone marrow-derived circulating progenitor cells (BM-CPCs) in patients with coronary heart disease are impaired with respect to number and functional activity. However, the relation between the functional acti...

    Authors: Ilkay Bozdag-Turan, R Goekmen Turan, Lylia Paranskaya, Nicole S Arsoy, C Hakan Turan, Ibrahim Akin, Stephan Kische, Jasmin Ortak, H Schneider, S Ludovicy, Tina Hermann, Giuseppe D’Ancona, Serkan Durdu, A Ruchan Akar, Hueseyin Ince and Christoph A Nienaber

    Citation: Journal of Translational Medicine 2012 10:143

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  30. Content type: Research

    Adipose derived mesenchymal stem cells (ADMSCs), carrying the similar characteristics to bone marrow mesenchymal stem cells, only much more abundant and easier to obtain, may be a promising treatment for liver...

    Authors: Yu Wang, Fan Lian, Jiaping Li, Wenzhe Fan, Hanshi Xu, Xiuyan Yang, Liuqin Liang, Wei Chen and Jianyong Yang

    Citation: Journal of Translational Medicine 2012 10:133

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  31. Content type: Research

    It has been reported that the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway regulates erythropoietin (EPO)-induced survival, proliferation, and maturation of early erythroid progenitors. Erythroid...

    Authors: Vladan P Cokic, Bhaskar Bhattacharya, Bojana B Beleslin-Cokic, Constance T Noguchi, Raj K Puri and Alan N Schechter

    Citation: Journal of Translational Medicine 2012 10:116

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  32. Content type: Research

    Previous experimental studies concluded that stem cells (SC) may exert their beneficial effects on the ischemic heart by paracrine activation of antiapoptotic pathways. In order to identify potential cardiopro...

    Authors: Mark Rosenberg, Matthias Lutz, Constantin Kühl, Rainer Will, Volker Eckstein, Jutta Krebs, Hugo A Katus and Norbert Frey

    Citation: Journal of Translational Medicine 2012 10:115

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  33. Content type: Methodology

    The quality and safety of advanced therapy products must be maintained throughout their production and quality control cycle to ensure their final use in patients. We validated the cell count method according ...

    Authors: Monica Gunetti, Sara Castiglia, Deborah Rustichelli, Katia Mareschi, Fiorella Sanavio, Michela Muraro, Elena Signorino, Laura Castello, Ivana Ferrero and Franca Fagioli

    Citation: Journal of Translational Medicine 2012 10:112

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  34. Content type: Research

    Cerebral palsy is currently one of the major diseases that cause severe paralysis of the nervous system in children; approximately 9–30% of cerebral palsy patients are also visually impaired, for which no effe...

    Authors: Min Li, Aixue Yu, Fangfang Zhang, GuangHui Dai, Hongbin Cheng, Xiaodong Wang and Yihua An

    Citation: Journal of Translational Medicine 2012 10:100

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  35. Content type: Research

    In vitro fabricated tissue engineered vascular constructs could provide an alternative to conventional substitutes. A crucial factor for tissue engineering of vascular constructs is an appropriate cell source. Va...

    Authors: Bianca Polchow, Kati Kebbel, Gerno Schmiedeknecht, Anne Reichardt, Wolfgang Henrich, Roland Hetzer and Cora Lueders

    Citation: Journal of Translational Medicine 2012 10:98

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  36. Content type: Research

    RhoA-Rho kinase complex contributes to keep the cavernosus smooth muscle contracted and its inhibition is considered a potential strategy for the therapy of erectile dysfunction (ED).

    Authors: Fabio Guagnini, Mara Ferazzini, Marco Grasso, Salvatore Blanco and Tiziano Croci

    Citation: Journal of Translational Medicine 2012 10:59

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  37. Content type: Research

    We conducted a pilot study of the infusion of intravenous autologous cord blood (CB) in children with cerebral palsy (CP) to assess the safety and feasibility of the procedure as well as its potential efficacy...

    Authors: Young-Ho Lee, Kyung Vin Choi, Jin Hwa Moon, Hyun-Joo Jun, Hye-Ryeong Kang, Se-In Oh, Hyung Sun Kim, Jang Soo Um, Mi Jung Kim, Yun Young Choi, Young-Jun Lee, Hee-Jin Kim, Jong-Hwa Lee, Su Min Son, Soo-Jin Choi, Wonil Oh…

    Citation: Journal of Translational Medicine 2012 10:58

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  38. Content type: Research

    This study evaluated the effectiveness of treating pseudarthrosis in rats by using bone marrow cell suspensions or cultures of bone marrow mesenchymal stromal cells

    Authors: Manoel Luiz Ferreira, Paulo Cesar Silva, Lucas Henrique Alvarez Silva, Danielle Cabral Bonfim, Lucas Cristo Conilho Macedo Müller, Christiano Costa Espósito and Alberto Schanaider

    Citation: Journal of Translational Medicine 2012 10:51

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  39. Content type: Research

    Human adipose-derived mesenchymal stem cells (ADMSCs) may be ideal source of cells for intervertebral disc (IVD) regeneration, but the harsh chemical microenvironment of IVD may significantly influence the bio...

    Authors: Chengzhen Liang, Hao Li, Yiqing Tao, Xiaopeng Zhou, Fangcai Li, Gang Chen and Qixin Chen

    Citation: Journal of Translational Medicine 2012 10:49

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  40. Content type: Research

    A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly...

    Authors: David F Stroncek, Carolina Berger, Martin A Cheever, Richard W Childs, Mark E Dudley, Peter Flynn, Luca Gattinoni, James R Heath, Michael Kalos, Francesco M Marincola, Jeffrey S Miller, Gustavo Mostoslavsky, Daniel J Powell Jr, Mahendra Rao, Nicholas P Restifo, Steven A Rosenberg…

    Citation: Journal of Translational Medicine 2012 10:48

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  41. Content type: Research

    Hepatitis C virus (HCV) causes liver fibrosis that may lead to liver cirrhosis or hepatocellular carcinoma (HCC), and may partially depend on infecting viral genotype. HCV genotype 3a is being more common in A...

    Authors: Waqar Ahmad, Bushra Ijaz and Sajida Hassan

    Citation: Journal of Translational Medicine 2012 10:41

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  42. Content type: Research

    Diabetic patients are at increased risk for bacterial infections; these studies provide new insight into the role of the host defense complement system in controlling bacterial pathogens in hyperglycemic envir...

    Authors: Pamela S Hair, Charlene G Echague, Reuben D Rohn, Neel K Krishna, Julius O Nyalwidhe and Kenji M Cunnion

    Citation: Journal of Translational Medicine 2012 10:35

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  43. Content type: Methodology

    There has been significant progress in the last two decades on the design of chimeric antigen receptors (CAR) for adoptive immunotherapy targeting tumor-associated antigens. Structurally CARs consist of a sing...

    Authors: Zhili Zheng, Nachimuthu Chinnasamy and Richard A Morgan

    Citation: Journal of Translational Medicine 2012 10:29

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  44. Content type: Methodology

    Bone marrow stromal cells (BMSCs) are being used to treat a variety of conditions. For many applications a supply of cryopreserved products that can be used for acute therapy is needed. The establishment of a ...

    Authors: Marianna Sabatino, Jiaqiang Ren, Virginia David-Ocampo, Lee England, Michael McGann, Minh Tran, Sergei A Kuznetsov, Hanh Khuu, Arun Balakumaran, Harvey G Klein, Pamela G Robey and David F Stroncek

    Citation: Journal of Translational Medicine 2012 10:23

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  45. Content type: Research

    Osteoblast and adipocyte are derived from common mesenchymal progenitor cells. The bone loss of osteoporosis is associated with altered progenitor differentiation from an osteoblastic to an adipocytic lineage....

    Authors: Li You, Ling Pan, Lin Chen, Jin-Yu Chen, Xiaoping Zhang, Zhongwei Lv and Da Fu

    Citation: Journal of Translational Medicine 2012 10:11

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  46. Content type: Research

    For clinical applications, dendritic cells (DCs) need to be generated using GMP-approved reagents. In this study, we tested the characteristics of DCs generated in two clinical grade culture media and activate...

    Authors: Jitka Fučíková, Daniela Rožková, Hana Ulčová, Vít Budinský, Klára Sochorová, Kateřina Pokorná, Jiřina Bartůňková and Radek Špíšek

    Citation: Journal of Translational Medicine 2011 9:223

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  47. Content type: Research

    Breast cancer stem cells (BCSCs) are the source of breast tumors. Compared with other cancer cells, cancer stem cells show high resistance to both chemotherapy and radiotherapy. Targeting of BCSCs is thus a po...

    Authors: Phuc V Pham, Nhan LC Phan, Nhung T Nguyen, Nhung H Truong, Thuy T Duong, Dong V Le, Kiet D Truong and Ngoc K Phan

    Citation: Journal of Translational Medicine 2011 9:209

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  48. Content type: Research

    Erythropoietin (EPO) is a glycoprotein hormone which is required to regulate the production of red blood cells. Deficiency of EPO is known to cause anemia in chronically infected renal patients and they requir...

    Authors: Humera Kausar, Sana Gull, Bushra Ijaz, Waqar Ahmad, Muhammad Tahir Sarwar, Zafar Iqbal, Zafar Nawaz, Sheikh Riazuddin and Sajida Hassan

    Citation: Journal of Translational Medicine 2011 9:186

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  49. Content type: Research

    Chronic refractory angina is a challenging clinical problem with limited treatment options. The results of early cardiovascular stem cell trials using ABMMC have been promising but have utilized intracoronary ...

    Authors: Jorge Tuma, Roberto Fernández-Viña, Antonio Carrasco, Jorge Castillo, Carlos Cruz, Alvaro Carrillo, Jose Ercilla, Carlos Yarleque, Jaime Cunza, Timothy D Henry and Amit N Patel

    Citation: Journal of Translational Medicine 2011 9:183

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  50. Content type: Protocol

    Idiopathic pulmonary fibrosis represents a lethal form of progressive fibrotic lung disorder with gradually increasing incidence worldwide. Despite intense research efforts its pathogenesis is still elusive an...

    Authors: Argyris Tzouvelekis, George Koliakos, Paschalis Ntolios, Irene Baira, Evangelos Bouros, Anastasia Oikonomou, Athanassios Zissimopoulos, George Kolios, Despoina Kakagia, Vassilis Paspaliaris, Ioannis Kotsianidis, Marios Froudarakis and Demosthenes Bouros

    Citation: Journal of Translational Medicine 2011 9:182

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