Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet. 2014;383:1749–61.
PubMed
Google Scholar
Higashi T, Friedman SL, Hoshida Y. Hepatic stellate cells as key target in liver fibrosis. Adv Drug Deliv Rev. 2017;121:27–42.
CAS
PubMed
PubMed Central
Google Scholar
Sanchez-Valle V, Chavez-Tapia NC, Uribe M, Mendez-Sanchez N. Role of oxidative stress and molecular changes in liver fibrosis: a review. Curr Med Chem. 2012;19:4850–60.
CAS
PubMed
Google Scholar
Krengel U, Tornroth-Horsefield S. Biochemistry. Coping with oxidative stress. Science. 2015;347:125–6.
CAS
PubMed
Google Scholar
Houglum K, Venkataramani A, Lyche K, Chojkier M. A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology. 1997;113:1069–73.
CAS
PubMed
Google Scholar
Stiedl P, McMahon R, Blaas L, Stanek V, Svinka J, Grabner B, Zollner G, et al. Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology. 2015;61:613–26.
CAS
PubMed
PubMed Central
Google Scholar
Schneiderhan W, Schmid-Kotsas A, Zhao J, Grunert A, Nussler A, Weidenbach H, Menke A, et al. Oxidized low-density lipoproteins bind to the scavenger receptor, CD36, of hepatic stellate cells and stimulate extracellular matrix synthesis. Hepatology. 2001;34:729–37.
CAS
PubMed
Google Scholar
Zamara E, Novo E, Marra F, Gentilini A, Romanelli RG, Caligiuri A, Robino G, et al. 4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells. J Hepatol. 2004;40:60–8.
CAS
PubMed
Google Scholar
Borkham-Kamphorst E, Weiskirchen R. The PDGF system and its antagonists in liver fibrosis. Cytokine Growth Factor Rev. 2016;28:53–61.
CAS
PubMed
Google Scholar
Nusse R, Clevers H. Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell. 2017;169:985–99.
CAS
PubMed
Google Scholar
Monga SP. β-Catenin signaling and roles in liver homeostasis, injury, and tumorigenesis. Gastroenterology. 2015;148:1294–310.
CAS
PubMed
PubMed Central
Google Scholar
Xiao Y, Liu J, Peng Y, Xiong X, Huang L, Yang H, Zhang J, et al. GSTA3 attenuates renal interstitial fibrosis by inhibiting TGF-beta-induced tubular epithelial–mesenchymal transition and fibronectin expression. PLoS ONE. 2016;11:e160855.
Google Scholar
Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51–88.
CAS
PubMed
Google Scholar
Hayes PC, Harrison DJ, Bouchier IA, McLellan LI, Hayes JD. Cytosolic and microsomal glutathione S-transferase isoenzymes in normal human liver and intestinal epithelium. Gut. 1989;30:854–9.
CAS
PubMed
PubMed Central
Google Scholar
Johansson A, Mannervik B. Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem. 2001;276:33061–5.
CAS
PubMed
Google Scholar
Crawford DR, Ilic Z, Guest I, Milne GL, Hayes JD, Sell S. Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice. Carcinogenesis. 2017;38:717–27.
CAS
PubMed
PubMed Central
Google Scholar
Lou Q, Meng X, Lao Z, Xuan L, Bai J, Hou Q, Hu G, et al. Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones. Molecules. 2012;17:884–96.
CAS
PubMed
PubMed Central
Google Scholar
Qin J, Mei W, Xie Y, Huang L, Yuan Q, Hu G, Tao L, et al. Fluorofenidone attenuates oxidative stress and renal fibrosis in obstructive nephropathy via blocking NOX2 (gp91phox) expression and inhibiting ERK/MAPK signaling pathway. Kidney Blood Press Res. 2015;40:89–99.
CAS
PubMed
Google Scholar
Peng Y, Yang H, Zhu T, Zhao M, Deng Y, Liu B, Shen H, et al. The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways. Eur J Clin Investig. 2013;43:358–68.
CAS
Google Scholar
Song C, He L, Zhang J, Ma H, Yuan X, Hu G, Tao L, et al. Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88/NF-κB pathway. J Cell Mol Med. 2016;20:2064–77.
CAS
PubMed
PubMed Central
Google Scholar
Peng Y, Yang H, Wang N, Ouyang Y, Yi Y, Liao L, Shen H, et al. Fluorofenidone attenuates hepatic fibrosis by suppressing the proliferation and activation of hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2014;306:G253–63.
CAS
PubMed
Google Scholar
Lee YA, Wallace MC, Friedman SL. Pathobiology of liver fibrosis: a translational success story. Gut. 2015;64:830–41.
CAS
PubMed
PubMed Central
Google Scholar
Houglum K, Filip M, Witztum JL, Chojkier M. Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. J Clin Investig. 1990;86:1991–8.
CAS
PubMed
Google Scholar
Fotouhi-Ardakani N, Batist G. Genomic cloning and characterization of the rat glutathione S-transferase-A3-subunit gene. Biochem J. 1999;339(Pt 3):685–93.
CAS
PubMed
PubMed Central
Google Scholar
Whalen R, Rockey DC, Friedman SL, Boyer TD. Activation of rat hepatic stellate cells leads to loss of glutathion S-transferases and their enzymatic activity against products of oxidative stress. Hepatology. 1999;30:927–33.
CAS
PubMed
Google Scholar
Gum SI, Jo SJ, Ahn SH, Kim SG, Kim J, Shin HM, Cho MK. The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo[α]pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTs. J Ethnopharmacol. 2007;112:568–76.
CAS
PubMed
Google Scholar
Montilla P, Cruz A, Padillo FJ, Tunez I, Gascon F, Munoz MC, Gomez M, et al. Melatonin versus vitamin E as protective treatment against oxidative stress after extra-hepatic bile duct ligation in rats. J Pineal Res. 2001;31:138–44.
CAS
PubMed
Google Scholar
Maeda K, Koda M, Matono T, Sugihara T, Yamamoto S, Ueki M, Murawaki Y, et al. Preventive effects of ME3738 on hepatic fibrosis induced by bile duct ligation in rats. Hepatol Res. 2008;38:727–35.
CAS
PubMed
Google Scholar
Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol. 2001;35:297–306.
CAS
PubMed
Google Scholar
Borkham-Kamphorst E, van Roeyen CRC, Ostendorf T, Floege J, Gressner AM, Weiskirchen R. Pro-fibrogenic potential of PDGF-D in liver fibrosis. J Hepatol. 2007;46:1064–74.
CAS
PubMed
Google Scholar
Adachi T, Togashi H, Suzuki A, Kasai S, Ito J, Sugahara K, Kawata S. NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells. Hepatology. 2005;41:1272–81.
CAS
PubMed
Google Scholar
Jowsey IR, Smith SA, Hayes JD. Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-delta 12,14-prostaglandin J2. Biochem Biophys Res Commun. 2003;312:1226–35.
CAS
PubMed
Google Scholar
Larroque-Cardoso P, Mucher E, Grazide M, Josse G, Schmitt A, Nadal-Wolbold F, Zarkovic K, et al. 4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts. Free Radic Biol Med. 2014;71:427–36.
CAS
PubMed
Google Scholar
Eleonore B, Steven FG, Richard SJ. Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. Pharmacol Ther. 2015;0:114–31.
Google Scholar
Kocabayoglu P, Lade A, Lee YA, Dragomir AC, Sun X, Fiel MI, Thung S, et al. β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis. J Hepatol. 2015;63:141–7.
CAS
PubMed
PubMed Central
Google Scholar
Dorion S, Lambert H, Landry J. Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1. J Biol Chem. 2002;277:30792–7.
CAS
PubMed
Google Scholar
Marcellin P, Gane E, Buti M, Afdhal N, Sievert W, Jacobson IM, Washington MK, et al. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet. 2013;381:468–75.
CAS
PubMed
Google Scholar
Gane EJ, Weilert F, Orr DW, Keogh GF, Gibson M, Lockhart MM, Frampton CM, et al. The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int. 2010;30:1019–26.
CAS
PubMed
Google Scholar
Di Leandro L, Maras B, Schininà ME, Dupré S, Koutris I, Martin FM, Naquet P, et al. Cystamine restores GSTA3 levels in Vanin-1 null mice. Free Radic Biol Med. 2008;44:1088–96.
PubMed
Google Scholar
Kim SK. Identification of the insulin signaling cascade in the regulation of alpha-class glutathione S-transferase expression in primary cultured rat hepatocytes. J Pharmacol Exp Ther. 2005;316:1255–61.
PubMed
Google Scholar
Kaffe E, Fiorotto R, Pellegrino F, Mariotti V, Amenduni M, Cadamuro M, Fabris L, et al. β-Catenin and interleukin-1β-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis. Hepatology. 2018;67:1903–19.
CAS
PubMed
PubMed Central
Google Scholar
Zhao G, Hatting M, Nevzorova YA, Peng J, Hu W, Boekschoten MV, Roskams T, et al. Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis. Gut. 2014;63:1159–72.
CAS
PubMed
Google Scholar