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Cell, tissue and gene therapy

Section edited by David Stroncek

This section aims to improve communication between basic and clinical research related to cell, tissue and gene therapies. Effective clinical therapies require efficient translation of research between the bench and bedside to allow the discovery, development, scale up, and production of cells, tissues and vectors. These therapies are being used to treat patients with a range of diseases including cancer, cardiovascular diseases, autoimmune disorders.

Studies considered for publication include those regarding the nature of cells, tissues and vectors used in clinical therapies; methods to collect, isolate and modify cells; and novel reagents, equipment, and instruments used in production. The section also welcomes research into the application of clinical therapies; factors that effect the safety and efficacy; in particular the potency, stability and purity of cells or tissue; and issues related to the safety of cell and tissue donors.

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  1. Content type: Research

    Within the last few years, it has become evident that LPS-preconditioned mesenchymal stromal cells (LPS pre-MSCs) show enhanced paracrine effects, including increased trophic support and improved regenerative ...

    Authors: Dongdong Ti, Haojie Hao, Chuan Tong, Jiejie Liu, Liang Dong, Jingxi Zheng, Yali Zhao, Huiling Liu, Xiaobing Fu and Weidong Han

    Citation: Journal of Translational Medicine 2015 13:308

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  2. Content type: Research

    Skeletal myoblasts (SkMs) has provided a promising treatment for myocardial infarction (MI). Functioning as posttranscriptional regulators, microRNAs (miRNAs) play important roles in cardiac repairment and s...

    Authors: Qi Liu, Guo Qing Du, Zhi Tao Zhu, ChunYang Zhang, Xiao Wei Sun, Jing Jin Liu, Xia Li, Yong Shun Wang and Wen Juan Du

    Citation: Journal of Translational Medicine 2015 13:270

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  3. Content type: Research

    Placental like alkaline phosphate (PLAP), an oncofetal antigen, is highly expressed in germ cell, cervical, ovarian and several other tumour types but minimally in normal tissues. The expression of a PLAP prom...

    Authors: Imran Khan, Mohammad Khalid Zakaria, Mukesh Kumar, Prashant Mani, Parthaprasad Chattopadhyay, Debi P Sarkar and Subrata Sinha

    Citation: Journal of Translational Medicine 2015 13:254

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    The Erratum to this article has been published in Journal of Translational Medicine 2015 13:300

  4. Content type: Research

    Non-healing wounds can pose a medical challenge as in the case of vasculopathic venostasis resulting in a surgical ulcer. When traditional approaches to wound care fail, an amniotic patch (a dehydrated tissue ...

    Authors: Neil H Riordan, Ben A George, Troy B Chandler and Randall W McKenna

    Citation: Journal of Translational Medicine 2015 13:242

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  5. Content type: Research

    Reactivation of latent viruses such as human cytomegalovirus (HCMV) after allogeneic hematopoietic stem cell transplantation (HSCT) results in high morbidity and mortality. Effective immunization against HCMV ...

    Authors: Bala Sai Sundarasetty, Stephan Kloess, Olaf Oberschmidt, Sonja Naundorf, Klaus Kuehlcke, Anusara Daenthanasanmak, Laura Gerasch, Constanca Figueiredo, Rainer Blasczyk, Eliana Ruggiero, Raffaele Fronza, Manfred Schmidt, Christof von Kalle, Michael Rothe, Arnold Ganser, Ulrike Koehl…

    Citation: Journal of Translational Medicine 2015 13:240

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  6. Content type: Research

    The rapid clinical translation of mesenchymal stem cells (MSC) has resulted in the development of cell-based strategies for multiple indications. Unfortunately one major barrier to widespread implementation of...

    Authors: Neil H Riordan, Marialaura Madrigal, Jason Reneau, Kathya de Cupeiro, Natalia Jiménez, Sergio Ruiz, Nelsy Sanchez, Thomas E Ichim, Francisco Silva and Amit N Patel

    Citation: Journal of Translational Medicine 2015 13:232

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  7. Content type: Research

    The intestinal stem cells (ISC) modulation and the role of circulating hematopoietic stem cells (HSC) in coeliac disease (CD) are poorly understood. Our aim was to investigate the longitudinal modifications in...

    Authors: Anna Chiara Piscaglia, Sergio Rutella, Lucrezia Laterza, Valentina Cesario, Mariachiara Campanale, Immacolata Alessia Cazzato, Gianluca Ianiro, Federico Barbaro, Luca Di Maurizio, Giuseppina Bonanno, Tonia Cenci, Giovanni Cammarota, Luigi Maria Larocca and Antonio Gasbarrini

    Citation: Journal of Translational Medicine 2015 13:220

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  8. Content type: Research

    Mesenchymal stromal cells (MSCs) expanded in vitro have been proposed as a potential therapy for congenital or acquired skin defects in pediatrics. The aim of this pre-clinical study was to investigate the ef...

    Authors: Gloria Pelizzo, Maria Antonietta Avanzini, Antonia Icaro Cornaglia, Monica Osti, Piero Romano, Luigi Avolio, Rita Maccario, Massimo Dominici, Annalisa De Silvestri, Erika Andreatta, Federico Costanzo, Melissa Mantelli, Daniela Ingo, Serena Piccinno and Valeria Calcaterra

    Citation: Journal of Translational Medicine 2015 13:219

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  9. Content type: Research

    Limited adjuvant treatment options exist for patients with high-risk surgically resected melanoma. This first-in-human study investigated the safety, tolerability and immunologic correlates of Melanoma GVAX, a...

    Authors: Evan J Lipson, William H Sharfman, Shuming Chen, Tracee L McMiller, Theresa S Pritchard, January T Salas, Susan Sartorius-Mergenthaler, Irwin Freed, Sowmya Ravi, Hao Wang, Brandon Luber, Janice Davis Sproul, Janis M Taube, Drew M Pardoll and Suzanne L Topalian

    Citation: Journal of Translational Medicine 2015 13:214

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  10. Content type: Research

    Mesenchymal stem cells (MSCs) are regarded as a promising cell-based therapeutic tool for tendon repair. This study aimed to compare the different tenogenic differentiation capacities of the three types of MSC...

    Authors: Linghui Dai, Xiaoqing Hu, Xin Zhang, Jingxian Zhu, Jiying Zhang, Xin Fu, Xiaoning Duan, Yingfang Ao and Chunyan Zhou

    Citation: Journal of Translational Medicine 2015 13:200

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  11. Content type: Research

    Myocardial infarction (MI) results in damaged heart tissue which can progress to severely reduce cardiac function, leading to death. Recent studies have injected dissociated, suspended cardiac cells into coron...

    Authors: Dolly Holt-Casper, Jeff M Theisen, Alonso P Moreno, Mark Warren, Francisco Silva, David W Grainger, David A Bull and Amit N Patel

    Citation: Journal of Translational Medicine 2015 13:194

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  12. Content type: Research

    The adoptive transfer of allogeneic antiviral T lymphocytes derived from seropositive donors can safely and effectively reduce or prevent the clinical manifestation of viral infections or reactivations in immu...

    Authors: Sabine Tischer, Christoph Priesner, Hans-Gert Heuft, Lilia Goudeva, Wolfgang Mende, Marc Barthold, Stephan Kloeß, Lubomir Arseniev, Krasimira Aleksandrova, Britta Maecker-Kolhoff, Rainer Blasczyk, Ulrike Koehl and Britta Eiz-Vesper

    Citation: Journal of Translational Medicine 2014 12:336

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  13. Content type: Research

    The present study evaluated the efficacy and safety of human embryonic stem cell (hESC) therapy in patients with CP.

    Authors: Geeta Shroff, Anupama Gupta and Jitender Kumar Barthakur

    Citation: Journal of Translational Medicine 2014 12:318

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    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:193

  14. Content type: Research

    Multipotent mesenchymal stem/stromal cells (MSC) including adipose-derived stromal cells (ADSC) have been successfully applied for cardiovascular diseases treatment. Their regenerative potential is considered ...

    Authors: Nina A Dzhoyashvili, Anastasia Yu Efimenko, Tatiana N Kochegura, Natalia I Kalinina, Natalia V Koptelova, Olga Yu Sukhareva, Marina V Shestakova, Renat S Akchurin, Vsevolod A Tkachuk and Yelena V Parfyonova

    Citation: Journal of Translational Medicine 2014 12:337

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  15. Content type: Protocol

    Kidney transplantation has improved survival and quality of life for patients with end-stage renal disease. Despite excellent short-term results due to better and more potent immunosuppressive drugs, long-term...

    Authors: Marlies EJ Reinders, Jonna R Bank, Geertje J Dreyer, Helene Roelofs, Sebastian Heidt, Dave L Roelen, Volkert AL Huurman, Jan Lindeman, Cees van Kooten, Frans HJ Claas, Wim E Fibbe, Ton J Rabelink and Johan W de Fijter

    Citation: Journal of Translational Medicine 2014 12:331

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  16. Content type: Research

    Although a variety of drugs have been used to treat the symptoms of rheumatoid arthritis (RA), none of them are able to cure the disease. Interferon β (IFN-β) has pleiotropic effects on RA, but whether it can ...

    Authors: Rong Zhao, Ni-Nan Chen, Xiao-Wei Zhou, Ping Miao, Chao-Ying Hu, Liu Qian, Qi-Wen Yu, Ji-Ying Zhang, Hong Nie, Xue-hua Chen, Pu Li, Rong Xu, Lian-Bo Xiao, Xin Zhang, Jian-Ren Liu and Dong-Qing Zhang

    Citation: Journal of Translational Medicine 2014 12:330

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  17. Content type: Research

    Dendritic cells are currently under investigation for their ability to generate anti-cancer immune responses. No consensus has been reached as to the optimal method of dendritic cell vaccine preparation and is...

    Authors: Mayu O Frank, Julia Kaufman, Salina Parveen, Nathalie E Blachère, Dana E Orange and Robert B Darnell

    Citation: Journal of Translational Medicine 2014 12:338

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  18. Content type: Research

    Endometriosis is a benign chronic gynecological disease that affects women of reproductive age, characterized by the presence of functional endometrial tissues outside the uterine cavity. GnRH agonists exhibit...

    Authors: Huinan Weng, Fenghua Liu, Shuiwang Hu, Li Li and Yifeng Wang

    Citation: Journal of Translational Medicine 2014 12:306

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  19. Content type: Research

    MicroRNA-200c (miR-200c) is one of the short noncoding RNAs that play crucial roles in tumorigenesis and tumor progression. It also acts as considerable modulator in the process of epithelial-to-mesenchymal tr...

    Authors: Lei Liu, Mingning Qiu, Guobin Tan, Ziji Liang, Yue Qin, Lieqian Chen, Hege Chen and Jianjun Liu

    Citation: Journal of Translational Medicine 2014 12:305

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  20. Content type: Review

    Graphene is a flat monolayer of carbon atoms, arranged in a two-dimensional hexagonal structure, with extraordinary electrical, thermal, and physical properties. Moreover, the molecular structure of graphene c...

    Authors: Eriberto Bressan, Letizia Ferroni, Chiara Gardin, Luca Sbricoli, Luca Gobbato, Francesco Saverio Ludovichetti, Ilaria Tocco, Amedeo Carraro, Adriano Piattelli and Barbara Zavan

    Citation: Journal of Translational Medicine 2014 12:296

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  21. Content type: Research

    We have previously reported that dephnetin is therapeutically effective in the treatment of rheumatoid arthritis (RA) in collagen-induced arthritis (CIA) rat model. However, the molecular mechanism and the eff...

    Authors: Kuanyong Shu, Nanzhen Kuang, Zhiqin Zhang, Ziling Hu, Yujuan Zhang, Yingyuan Fu and Weiping Min

    Citation: Journal of Translational Medicine 2014 12:287

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  22. Content type: Review

    The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the early paradigm of cell replacement and differentiation as a therapeutic mechanism of action, evidence is mounting th...

    Authors: Marialaura Madrigal, Kosagisharaf S Rao and Neil H Riordan

    Citation: Journal of Translational Medicine 2014 12:260

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  23. Content type: Research

    Despite advancements in wound healing techniques and devices, new treatments are needed to improve therapeutic outcomes. This study aimed to evaluate the potential use of a new biomaterial engineered from huma...

    Authors: Yinxin Fu, Junjie Guan, Shangchun Guo, Fei Guo, Xin Niu, Qiang Liu, Changqing Zhang, Huarong Nie and Yang Wang

    Citation: Journal of Translational Medicine 2014 12:274

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  24. Content type: Methodology

    Cardiovascular cell therapy represents a promising field, with several approaches currently being tested. The advanced therapy medicinal product (ATMP) for the ongoing METHOD clinical study ("Bone marrow deriv...

    Authors: Marina Radrizzani, Viviana Lo Cicero, Sabrina Soncin, Sara Bolis, Daniel Sürder, Tiziano Torre, Francesco Siclari, Tiziano Moccetti, Giuseppe Vassalli and Lucia Turchetto

    Citation: Journal of Translational Medicine 2014 12:276

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  25. Content type: Research

    The deregulation of microRNAs has been reported to play a pivotal role in hepatocellular carcinoma (HCC). MiR-126-3p has been reported to be associated with poor prognosis in HCC. However the underlying mechan...

    Authors: Chengli Du, Zhen Lv, Linping Cao, Chaofeng Ding, Owusu-ansah K Gyabaah, Haiyang Xie, Lin Zhou, Jian Wu and Shusen Zheng

    Citation: Journal of Translational Medicine 2014 12:259

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  26. Content type: Research

    Peripheral blood mononuclear cells (PBMC) concentrates collected by apheresis are frequently used as starting material for cellular therapies, but the cell of interest must often be isolated prior to initiatin...

    Authors: David F Stroncek, Vicki Fellowes, Chauha Pham, Hanh Khuu, Daniel H Fowler, Lauren V Wood and Marianna Sabatino

    Citation: Journal of Translational Medicine 2014 12:241

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  27. Content type: Research

    At present, no effective clinical treatment is available for the late effects of radiation myelopathy. The aim of the present study was to assess the therapeutic effects of human umbilical cord-derived mesench...

    Authors: Li Wei, Jing Zhang, Xiu-Bin Xiao, Hai-Xing Mai, Ke Zheng, Wan-Liang Sun, Lei Wang, Feng Liang, Zai-Liang Yang, Yuan Liu, Yan-Qing Wang, Zhi-Fang Li, Jia-Ning Wang, Wei-Jing Zhang and Hua You

    Citation: Journal of Translational Medicine 2014 12:246

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  28. Content type: Research

    Aberrant expression of miR-1 has been implicated in various cancers. However, the mechanisms underlying the role of miR-1 in CRC progression still have not been clarified clearly. Here, we showed the decreased...

    Authors: Lijun Xu, Yue Zhang, Hui Wang, Guanhua Zhang, Yanqing Ding and Liang Zhao

    Citation: Journal of Translational Medicine 2014 12:244

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  29. Content type: Review

    The inadequacy of existing therapeutic tools together with the paucity of organ donors have always led medical researchers to innovate the current treatment methods or to discover new ways to cure disease. Eme...

    Authors: Thekkeparambil Chandrabose Srijaya, Thamil Selvee Ramasamy and Noor Hayaty Abu Kasim

    Citation: Journal of Translational Medicine 2014 12:243

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  30. Content type: Research

    HLA-haploidentical hematopoietic stem cell transplantation (HSCT) is suitable for patients lacking related or unrelated HLA-matched donors. Herein, we investigated whether plerixafor (MZ), as an adjunct to G-C...

    Authors: Sergio Rutella, Perla Filippini, Valentina Bertaina, Giuseppina Li Pira, Lidia Altomare, Stefano Ceccarelli, Letizia P Brescia, Barbarella Lucarelli, Elia Girolami, Gianpiero Conflitti, Maria Giuseppina Cefalo, Alice Bertaina, Tiziana Corsetti, Lorenzo Moretta and Franco Locatelli

    Citation: Journal of Translational Medicine 2014 12:240

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  31. Content type: Review

    Activation of the PI3K/AKT pathway, a common mechanism in all subtypes of endometrial cancers (endometrioid and non-endometrioid tumors), has important roles in contributing to epithelial-mesenchymal transitio...

    Authors: Peixin Dong, Yosuke Konno, Hidemichi Watari, Masayoshi Hosaka, Masayuki Noguchi and Noriaki Sakuragi

    Citation: Journal of Translational Medicine 2014 12:231

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  32. Content type: Research

    High mobility group box protein 1 (HMGB1) acts as an endogenous danger molecule that is released from necrotic cells and activated macrophages. We have previously shown that peptide Hp91, whose sequence corres...

    Authors: Rebecca Saenz, Diahnn Futalan, Lien Leutenez, Fien Eekhout, Jessie F Fecteau, Simeon Sundelius, Stig Sundqvist, Marie Larsson, Tomoko Hayashi, Boris Minev, Dennis Carson, Sadik Esener, Bradley Messmer and Davorka Messmer

    Citation: Journal of Translational Medicine 2014 12:211

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  33. Content type: Research

    Transcription factor Sp1 is multifaceted, with the ability to function as an oncogene or a tumor suppressor, depending on the cellular context. We previously reported that Sp1 is required for the transcription...

    Authors: Jing-Ping Zhang, Hua Zhang, Hong-Bo Wang, Yan-Xian Li, Gui-Hong Liu, Shan Xing, Man-Zhi Li and Mu-Sheng Zeng

    Citation: Journal of Translational Medicine 2014 12:222

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  34. Content type: Research

    The biologic heterogeneity of soft tissue sarcomas (STS), even within histological subtypes, complicates treatment. In earlier studies, gene expression patterns that distinguish two subsets of clear cell renal...

    Authors: Keith M Skubitz, Amy PN Skubitz, Wayne W Xu, Xianghua Luo, Pauline Lagarde, Jean-Michel Coindre and Frédéric Chibon

    Citation: Journal of Translational Medicine 2014 12:176

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  35. Content type: Research

    Human bone marrow mesenchymal stem cells (hBMSCs) are multipotent cells that can differentiate into a variety of cell types. Elevated expression of peroxisome proliferator-activated receptor-γ (PPARγ) promotes...

    Authors: Junkui Sun, Yisheng Wang, Yuebai Li and Guoqiang Zhao

    Citation: Journal of Translational Medicine 2014 12:168

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  36. Content type: Research

    Rheumatoid arthritis (RA) is a debilitating and painful disease leading to increased morbidity and mortality and novel therapeutic approaches are needed. The purpose of this study was to elucidate if mesenchym...

    Authors: Oksana Kehoe, Alison Cartwright, Ayman Askari, Alicia J El Haj and Jim Middleton

    Citation: Journal of Translational Medicine 2014 12:157

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  37. Content type: Research

    Previous reports showed the presence of limited numbers of stem cells in neonatal murine cochlear sensory epithelia and these cells are progressively lost during the postnatal development. The goal of this stu...

    Authors: Xiangxin Lou, Youyi Dong, Jing Xie, Xianliu Wang, Liangliang Yang, Masaaki Tokuda and Yanzhong Zhang

    Citation: Journal of Translational Medicine 2014 12:150

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  38. Content type: Research

    While substantial progress has been made in blocking acute transplant rejection with the advent of immune suppressive drugs, chronic rejection, mediated primarily by recipient antigen presentation, remains a f...

    Authors: Xusheng Zhang, Yanling Liu, Guangfeng Zhang, Jun Shi, Xiao Zhang, Xiufen Zheng, Alex T Jiang, Zhu-Xu Zhang, Nathan Johnston, King Sun Siu, Ruiqi Chen, Dameng Lian, David Koos, Douglas Quan and Wei-Ping Min

    Citation: Journal of Translational Medicine 2014 12:142

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  39. Content type: Research

    Diabetes mellitus (DM) is an incurable metabolic disease constituting a major threat to human health. Insulin-producing cells (IPCs) differentiated from mesenchymal stem cells (MSCs) hold great promise in the ...

    Authors: Huiting Qu, Xiaoli Liu, Yihong Ni, Yang Jiang, Xiaoli Feng, Juan Xiao, Yanan Guo, Dexiao Kong, Ai Li, Xiaomei Li, Xianghua Zhuang, Zhilun Wang, Yongjing Wang, Yali Chang, Shihong Chen, Feng Kong…

    Citation: Journal of Translational Medicine 2014 12:135

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  40. Content type: Research

    The Forkhead box M1 (FOXM1), an important regulator of cell differentiation and proliferation, is overexpressed in a number of aggressive human carcinomas. The purpose of this study was to examine the expressi...

    Authors: Ning Wen, Yu Wang, Li Wen, Shu-Hua Zhao, Zhen-Hua Ai, Yi Wang, Bo Wu, Huai-Xiu Lu, Hong Yang, Wen-Chao Liu and Yu Li

    Citation: Journal of Translational Medicine 2014 12:134

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  41. Content type: Review

    Interleukin-2 (IL-2) therapy has been demonstrated to induce responses in 10-20% of advanced melanoma and renal cell carcinoma patients, which translates into durable remissions in up to half of the responsers...

    Authors: Samuel C Wagner, Boris Markosian, Naseem Ajili, Brandon R Dolan, Andy J Kim, Doru T Alexandrescu, Constantin A Dasanu, Boris Minev, James Koropatnick, Francesco M Marincola and Neil H Riordan

    Citation: Journal of Translational Medicine 2014 12:127

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  42. Content type: Research

    Bone tissue engineering is a new approach for the repair of orbital defects. The aim of the present study was to explore the feasibility of tissue-engineered bone constructed using bone marrow stromal cells (B...

    Authors: Yefei Wang, Xiaoping Bi, Huifang Zhou, Yuan Deng, Jing Sun, Caiwen Xiao, Ping Gu and Xianqun Fan

    Citation: Journal of Translational Medicine 2014 12:123

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  43. Content type: Research

    Multiple myeloma is characterized by clonal expansion of B cells producing monoclonal immunoglobulins or fragments thereof, which can be detected in the serum and/or urine and are ideal target antigens for pat...

    Authors: Tim Roehnisch, Cornelia Then, Wolfgang Nagel, Christina Blumenthal, Todd Braciak, Mariel Donzeau, Thomas Böhm, Michael Flaig, Carole Bourquin and Fuat S Oduncu

    Citation: Journal of Translational Medicine 2014 12:119

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  44. Content type: Research

    Autologous transplantation of modified mesenchymal stem cells (MSCs) is a promising candidate for the treatment of the refractory clinical disease, avascular necrosis of the femoral head (ANFH). Our previous a...

    Authors: Qian Wen, Chaoying Zhou, Wei Luo, Mingqian Zhou and Li Ma

    Citation: Journal of Translational Medicine 2014 12:114

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  45. Content type: Research

    In osteosarcoma (OS) and most Ewing sarcoma (EWS) patients, the primary tumor originates in the bone. Although tumor resection surgery is commonly used to treat these diseases, it frequently leaves massive bon...

    Authors: Enrico Lucarelli, Chiara Bellotti, Melissa Mantelli, Maria Antonietta Avanzini, Rita Maccario, Francesca Novara, Giulia Arrigo, Orsetta Zuffardi, Monia Zuntini, Martina Pandolfi, Luca Sangiorgi, Daniela Lisini, Davide Donati and Serena Duchi

    Citation: Journal of Translational Medicine 2014 12:95

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  46. Content type: Research

    Alpha fetoprotein (AFP) is an oncofetal antigen over-expressed by many hepatocellular cancers (HCC). We previously demonstrated that HLA-A2-restricted epitopes derived from AFP are immunogenic in vitro and in viv...

    Authors: Lisa H Butterfield, James S Economou, T Clark Gamblin and David A Geller

    Citation: Journal of Translational Medicine 2014 12:86

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