Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood. 2003;102:449–61.
Article
CAS
PubMed
Google Scholar
Li Z, Delaney MK, O’Brien KA, Du X. Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol. 2010;30:2341–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Weyrich AS, Denis MM, Hansjorg S, Tolley ND, Jason F, Eliott S, Kraiss LW, Albertine KH, Mcintyre TM, Zimmerman GA. mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood. 1975;2007:109.
Google Scholar
Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012;149:274–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Phung TL, Ziv K, Dabydeen D, Eyiah-Mensah G, Riveros M, Perruzzi C, Sun J, Monahan-Earley RA, Shiojima I, Nagy JA, et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell. 2006;10:159–70.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell. 2006;22:159–68.
Article
CAS
PubMed
Google Scholar
Dobbelstein M, Moll U. Targeting tumour-supportive cellular machineries in anticancer drug development. Nat Rev Drug Discov. 2014;13:179–96.
Article
CAS
PubMed
Google Scholar
Moschetta M, Reale A, Marasco C, Vacca A, Carratu MR. Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations. Br J Pharmacol. 2014;171:3801–13.
Article
CAS
PubMed
PubMed Central
Google Scholar
Moore SF, Hunter RW, Hers I. mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]. J Biol Chem. 2011;286:24553–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Moore SF, Hunter RW, Hers I. Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets. J Thromb Haemost. 2014;12:748–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wu Q, Huang KS, Chen M, Huang DJ. Rapamycin enhances platelet aggregation induced by adenosine diphosphate in vitro. Platelets. 2009;20:428–31.
Article
CAS
PubMed
Google Scholar
Babinska A, Markell MS, Salifu MO, Akoad M, Ehrlich YH, Kornecki E. Enhancement of human platelet aggregation and secretion induced by rapamycin. Nephrol Dial Transplant. 1998;13:3153–9.
Article
CAS
PubMed
Google Scholar
Aslan JE, Tormoen GW, Loren CP, Pang J, McCarty OJ. S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood. 2011;118:3129–36.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, Spetz JF, Um SH, Brown EJ, Cereghini S, Thomas G, Kozma SC. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol. 2004;24:9508–16.
Article
CAS
PubMed
PubMed Central
Google Scholar
Holz MK, Ballif BA, Gygi SP, Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell. 2005;123:569–80.
Article
CAS
PubMed
Google Scholar
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005;307:1098–101.
Article
CAS
PubMed
Google Scholar
Franco R, Martínez-Pinilla E, Navarro G, Zamarbide M. Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer’s disease. Prog Neurobiol. 2017;149–150:21–38.
Article
PubMed
CAS
Google Scholar
Pal HC, Hunt KM, Diamond A, Elmets CA, Afaq F. Phytochemicals for the Management of Melanoma. Mini Rev Med Chem. 2016;16:953–79.
Article
CAS
PubMed
PubMed Central
Google Scholar
Buitrago L, Bhavanasi D, Dangelmaier C, Manne BK, Badolia R, Borgognone A, Tsygankov AY, McKenzie SE, Kunapuli SP. Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms. J Biol Chem. 2013;288:29160–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bynagari-Settipalli YS, Lakhani P, Jin J, Bhavaraju K, Rico MC, Kim S, Woulfe D, Kunapuli SP. Protein kinase C isoform epsilon negatively regulates ADP-induced calcium mobilization and thromboxane generation in platelets. Arterioscler Thromb Vasc Biol. 2012;32:1211–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chari R, Getz T, Nagy B Jr, Bhavaraju K, Mao Y, Bynagari YS, Murugappan S, Nakayama K, Kunapuli SP. Protein kinase C[delta] differentially regulates platelet functional responses. Arterioscler Thromb Vasc Biol. 2009;29:699–705.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chari R, Kim S, Murugappan S, Sanjay A, Daniel JL, Kunapuli SP. Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion. Blood. 2009;114:3056–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cohen S, Braiman A, Shubinsky G, Isakov N. Protein kinase C-theta in platelet activation. FEBS Lett. 2011;585:3208–15.
Article
CAS
PubMed
Google Scholar
Harper MT, Poole AW. Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation. J Thromb Haemost. 2010;8:454–62.
Article
CAS
PubMed
Google Scholar
Konopatskaya O, Gilio K, Harper MT, Zhao Y, Cosemans JM, Karim ZA, Whiteheart SW, Molkentin JD, Verkade P, Watson SP, et al. PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest. 2009;119:399–407.
CAS
PubMed
PubMed Central
Google Scholar
Konopatskaya O, Matthews SA, Harper MT, Gilio K, Cosemans JM, Williams CM, Navarro MN, Carter DA, Heemskerk JW, Leitges M, et al. Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood. 2011;118:416–24.
Article
CAS
PubMed
Google Scholar
Moncada de la Rosa C, Radziwon-Balicka A, El-Sikhry H, Seubert J, Ruvolo PP, Radomski MW, Jurasz P. Pharmacologic protein kinase Calpha inhibition uncouples human platelet-stimulated angiogenesis from collagen-induced aggregation. J Pharmacol Exp Ther. 2013;345:15–24.
Article
CAS
PubMed
Google Scholar
Pears CJ, Thornber K, Auger JM, Hughes CE, Grygielska B, Protty MB, Pearce AC, Watson SP. Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets. PLoS ONE. 2008;3:e3793.
Article
PubMed
PubMed Central
CAS
Google Scholar
Pula G, Schuh K, Nakayama K, Nakayama KI, Walter U, Poole AW. PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. Blood. 2006;108:4035–44.
Article
CAS
PubMed
Google Scholar
Unsworth AJ, Finney BA, Navarro-Nunez L, Severin S, Watson SP, Pears CJ. Protein kinase Cepsilon and protein kinase Ctheta double-deficient mice have a bleeding diathesis. J Thromb Haemost. 2012;10:1887–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xiang B, Zhang G, Stefanini L, Bergmeier W, Gartner TK, Whiteheart SW, Li Z. The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation. J Biol Chem. 2012;287:41277–87.
Article
CAS
PubMed
PubMed Central
Google Scholar
Karim ZA, Alshbool FZ, Vemana HP, Conlon C, Druey KM, Khasawneh FT. CXCL12 regulates platelet activation via the regulator of G-protein signaling 16. Biochim Biophys Acta. 2016;1863:314–21.
Article
CAS
PubMed
Google Scholar
Buensuceso CS, Obergfell A, Soriani A, Eto K, Kiosses WB, Arias-Salgado EG, Kawakami T, Shattil SJ. Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta. J Biol Chem. 2005;280:644–53.
Article
CAS
PubMed
Google Scholar
Soriani A, Moran BVM, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ. A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost. 2006;4:648–55.
Article
CAS
PubMed
Google Scholar
Swaminathan Murugappan FT, Robert T. Dorsam, Haripriya Shankar, Kunapuli aSP: differential role of protein kinase C delta isoform in agonist-induced dense granule secretion in human platelets. J Biol Chem. 2004;279:2360–7.
Article
PubMed
CAS
Google Scholar
Cohen S, Braiman A, Shubinsky G, Ohayon A, Altman A, Isakov N. PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion. Biochem Biophys Res Commun. 2009;385:22–7.
Article
CAS
PubMed
Google Scholar
Bynagari YS, Nagy B Jr, Tuluc F, Bhavaraju K, Kim S, Vijayan KV, Kunapuli SP. Mechanism of activation and functional role of protein kinase Ceta in human platelets. J Biol Chem. 2009;284:13413–21.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gobbi G, Mirandola P, Sponzilli I, Micheloni C, Malinverno C, Cocco L, Vitale M. Timing and expression level of protein kinase C epsilon regulate the megakaryocytic differentiation of human CD34 cells. Stem Cells. 2007;25:2322–9.
Article
CAS
PubMed
Google Scholar
Hall KJ, Harper MT, Gilio K, Cosemans JM, Heemskerk JW, Poole AW. Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation. PLoS ONE. 2008;3:e3277.
Article
PubMed
PubMed Central
CAS
Google Scholar
Xu ZB, Chaudhary D, Olland S, Wolfrom S, Czerwinski R, Malakian K, Lin L, Stahl ML, Joseph-McCarthy D, Benander C, et al. Catalytic domain crystal structure of protein kinase C-theta (PKCtheta). J Biol Chem. 2004;279:50401–9.
Article
CAS
PubMed
Google Scholar
Nagy B, Bhavaraju K, Getz T, Bynagari YS, Kim S, Kunapuli SP. Impaired activation of platelets lacking protein kinase C-θ isoform. Blood. 2009;113:2557–67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Steinberg SF. Structural basis of protein kinase C isoform function. Physiol Rev. 2008;88:1341–78.
Article
CAS
PubMed
Google Scholar
Morton LF, Hargreaves PG, Farndale RW, Young RD, Barnes MJ. Integrin alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-independent platelet reactivity. Biochem J. 1995;306(Pt 2):337–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavallaro G, Banci L, Guo Y, Bolli R. Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc Natl Acad Sci USA. 2001;98:11114–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dorn GW, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN, Mochly-Rosen D. Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proc Natl Acad Sci U S A. 1999;96:12798–803.
Article
CAS
PubMed
PubMed Central
Google Scholar
Johnson JA, Gray MO, Chen C-H, Mochly-Rosen D. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. J Biol Chem. 1996;271:24962–6.
Article
CAS
PubMed
Google Scholar
Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol. 2007;43:517–22.
Article
CAS
PubMed
Google Scholar
Sweitzer SM, Wong SM, Peters MC, Mochly-Rosen D, Yeomans DC, Kendig JJ. Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats. J Pharmacol Exp Ther. 2004;309:616.
Article
CAS
PubMed
Google Scholar
Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science. 1999;285:1569–72.
Article
CAS
PubMed
Google Scholar
Risson V, Mazelin L, Roceri M, Sanchez H, Moncollin V, Corneloup C, Richard-Bulteau H, Vignaud A, Baas D, Defour A, et al. Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. J Cell Biol. 2009;187:859–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ralph T, Tibor S, Hui HS, Skoda RC. Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood. 2007;109:1503–6.
Article
CAS
Google Scholar
Gao C, Boylan B, Fang J, Wilcox DA, Newman DK, Newman PJ. Heparin promotes platelet responsiveness by potentiating alphaIIbbeta3-mediated outside-in signaling. Blood. 2011;117:4946–52.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dai B, Wu P, Xue F, Yang R, Yu Z, Dai K, Ruan C, Liu G, Newman PJ, Gao C. Integrin-alphaIIbbeta3-mediated outside-in signalling activates a negative feedback pathway to suppress platelet activation. Thromb Haemost. 2016;116:918–30.
Article
PubMed
Google Scholar
Khatlani T, Pradhan S, Da Q, Gushiken FC, Bergeron AL, Langlois KW, Molkentin JD, Rumbaut RE, Vijayan KV. The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αIIbβ3 integrin signaling. J Thromb Haemost. 2015;12:2089–101.
Article
CAS
Google Scholar
Garcia A, Kim S, Bhavaraju K, Schoenwaelder SM, Kunapuli SP. Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways. Biochem J. 2010;429:369–77.
Article
CAS
PubMed
Google Scholar
Conant CG, Nevill JT, Zhou Z, Dong JF, Schwartz MA, Ionescu-Zanetti C. Using well-plate microfluidic devices to conduct shear-based thrombosis assays. J Lab Autom. 2011;16:148–52.
Article
CAS
PubMed
Google Scholar
Hughes CE, Finney BA, Koentgen F, Lowe KL, Watson SP. The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets. Blood. 2015;125:144–54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Daria MR, Kanad D, Grimes KV. Protein kinase C, an elusive therapeutic target? Nat Rev Drug Discov. 2012;11:937–57.
Article
CAS
Google Scholar
Way KJ, Chou E, King GL. Identification of PKC-isoform-specific biological actions using pharmacological approaches. Trends Pharmacol Sci. 2000;21:181–7.
Article
CAS
PubMed
Google Scholar
Xiao G-Q, Qu Y, Sun Z-Q, Mochly-Rosen D, Boutjdir M. Evidence for functional role of εPKC isozyme in the regulation of cardiac Na+ channels. Am J Physiol Cell Physiol. 2001;281:C1477–86.
Article
CAS
PubMed
Google Scholar
Pan CJ, Tang JJ, Weng YJ, Wang J, Huang N. Preparation and characterization of rapamycin-loaded PLGA coating stent. J Mater Sci Mater Med. 2007;18:2193–8.
Article
CAS
PubMed
Google Scholar
Shuchman M. Trading restenosis for thrombosis? New questions about drug-eluting stents. N Engl J Med. 2006;355:1949–52.
Article
CAS
PubMed
Google Scholar
Mukhopadhyay NK, Price DJ, Kyriakis JM, Pelech S, Sanghera J, Avruch J. An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase. J Biol Chem. 1992;267:3325–35.
Article
CAS
PubMed
Google Scholar
Raslova H, Baccini V, Loussaief L, Comba B, Larghero J, Debili N, Vainchenker W. Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation. Blood. 2006;107:2303–10.
Article
CAS
PubMed
Google Scholar
Yang J, Zhou X, Fan X, Xiao M, Yang D, Liang B, Dai M, Shan L, Lu J, Lin Z. mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation. Blood. 2016;128:615–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Furie BFB. In vivo thrombus formation. J Thromb Haemost. 2007;5:12–7.
Article
CAS
PubMed
Google Scholar
Tseng MT, Dozier A, Haribabu B, Graham UM. Transendothelial migration of ferric ion in FeCl3 injured murine common carotid artery. Thromb Res. 2006;118:275–80.
Article
CAS
PubMed
Google Scholar
Eckly A, Hechler B, Freund M, Zerr M, Cazenave JP, Lanza F, Mangin PH, Gachet C. Mechanisms underlying FeCl3-induced arterial thrombosis. J Thromb Haemost. 2011;9:779–89.
Article
CAS
PubMed
Google Scholar
Greene TK, Schiviz A, Hoellriegl W, Poncz M, Muchitsch EM. Animal models subcommittee of the S, standardization committee of the I: towards a standardization of the murine tail bleeding model. J Thromb Haemost. 2010;8:2820–2.
Article
CAS
PubMed
Google Scholar
Santini E, Heiman M, Greengard P, Valjent E, Fisone G. Inhibition of mTOR signaling in Parkinson’s disease prevents L-DOPA-induced dyskinesia. Sci Signal. 2009;2:ra36.
Article
PubMed
Google Scholar
Santini E, Alcacer C, Cacciatore S, Heiman M, Herve D, Greengard P, Girault JA, Valjent E, Fisone G. L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice. J Neurochem. 2009;108:621–33.
Article
CAS
PubMed
Google Scholar
Pullen N. Phosphorylation and activation of p70s6k by PDK1. Science. 1998;279:707–10.
Article
CAS
PubMed
Google Scholar
Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem. 2007;282:14056–64.
Article
CAS
PubMed
Google Scholar
Selman CTJ, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science. 2009;326:140–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dennis PB, Pullen N, Pearson RB, Kozma SC, Thomas G. Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation. J Biol Chem. 1998;273:14845–52.
Article
CAS
PubMed
Google Scholar
Guo F, Zhang S, Grogg M, Cancelas JA, Varney ME, Starczynowski DT, Du W, Yang JQ, Liu W, Thomas G, et al. Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica. 2013;98:1353–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gan B, Sahin E, Jiang S, Sanchezaguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, Depinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci USA. 2008;105:19384–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kalaitzidis D, Sykes Stephen M, Wang Z, Punt N, Tang Y, Ragu C, Sinha Amit U, Lane Steven W, Souza Amanda L, Clish Clary B, et al. mTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012;11:429–39.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kuhn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science. 1995;269:1427–9.
Article
CAS
PubMed
Google Scholar
Musumeci L, Kuijpers MJ, Gilio K, Hego A, Theatre E, Maurissen L, Vandereyken M, Diogo CV, Lecut C, Guilmain W, et al. Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis. Circulation. 2015;131:656–68.
Article
CAS
PubMed
Google Scholar
Flevaris P, Stojanovic A, Gong H, Chishti A, Welch E, Du X. A molecular switch that controls cell spreading and retraction. J Cell Biol. 2007;179:553–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gong H, Shen B, Flevaris P, Chow C, Lam SC, Voyno-Yasenetskaya TA, Kozasa T, Du X. G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin “outside-in” signaling. Science. 2010;327:340–3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shen B, Zhao X, O’Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SC, Du X. A directional switch of integrin signalling and a new anti-thrombotic strategy. Nature. 2013;503:131–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pernice HF, Schieweck R, Kiebler MA, Popper B. mTOR and MAPK: from localized translation control to epilepsy. Bmc Neurosci. 2016;17:73.
Article
PubMed
PubMed Central
CAS
Google Scholar
Gangarossa G, Perroy J, Valjent E. Combinatorial topography and cell-type specific regulation of the ERK pathway by dopaminergic agonists in the mouse striatum. Brain Struct Funct. 2013;218:405–19.
Article
CAS
PubMed
Google Scholar
Gobert D, Topolnik L, Azzi M, Huang L, Badeaux F, Desgroseillers L, Sossin WS, Lacaille JC. Forskolin induction of late-LTP and up-regulation of 5’ TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells. J Neurochem. 2008;106:1160–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen XG, Liu F, Song XF, Wang ZH, Dong ZQ, Hu ZQ, Lan RZ, Guan W, Zhou TG, Xu XM, Lei H. Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways. Mol Carcinogen. 2010;49:603–10.
Article
CAS
Google Scholar
Edwards BS, Isom WJ, Navratil AM. Gonadotropin releasing hormone activation of the mTORC2/Rictor complex regulates actin remodeling and ERK activity in LbetaT2 cells. Mol Cell Endocrinol. 2016;439:346–53.
Article
PubMed
PubMed Central
CAS
Google Scholar
Jindra PT, Jin YP, Jacamo R, Rozengurt E, Reed EF. MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway. Biochem Biophys Res Commun. 2008;369:781–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Qingsong L, Jae Won C, Jinhua W, Kang SA, Thoreen CC, Andrew M, Wooyoung H, Jianming Z, Taebo S, Sabatini DM. Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J Med Chem. 2010;53:7146–55.
Article
CAS
Google Scholar
Aslan JE, Mccarty OJT. Regulation of the mTOR-Rac1 axis in platelet function. Small Gtpases. 2012;3:67–70.
Article
PubMed
PubMed Central
Google Scholar
Moroi AJ, Watson SP. Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: haemostasis, platelet activation and antithrombotic therapy. Biochem Pharmacol. 2015;94:186–94.
Article
CAS
PubMed
Google Scholar
Yue M, Luo D, Yu S, Liu P, Zhou Q, Hu M, Liu Y, Wang S, Huang Q, Niu Y, et al. Misshapen/NIK-related kinase (MINK1) is involved in platelet function, hemostasis, and thrombus formation. Blood. 2016;127:927–37.
Article
CAS
PubMed
Google Scholar
Vilahur G, Gutiérrez M, Arzanauskaite M, Mendieta G, Ben-Aicha S, Badimon L. Intracellular platelet signalling as a target for drug development. Vascul Pharmacol. 2018;111:22–5.
Article
CAS
PubMed
Google Scholar
Haimovich BKN, Ji P. Protein kinase C regulates tyrosine phosphorylation of pp125FAK in platelets adherent to fibrinogen. Blood. 1996;87:152–61.
Article
CAS
PubMed
Google Scholar
Gilio K, Harper MT, Cosemans JM, Konopatskaya O, Munnix IC, Prinzen L, Leitges M, Liu Q, Molkentin JD, Heemskerk JW, Poole AW. Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. J Biol Chem. 2010;285:23410–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Unsworth AJ, Smith H, Gissen P, Watson SP, Pears CJ. Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+. J Biol Chem. 2011;286:21073–82.
Article
CAS
PubMed
PubMed Central
Google Scholar