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Cardiovascular, metabolic and Lipoprotein translation

Section edited by Nehal N. Mehta

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

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  1. Content type: Research

    We aimed to determine the circulating miRNA expression profile associated with BAV and aortic dilation to provide diagnostic and prognostic biomarkers for BAV and/or aortic dilation.

    Authors: Neus Martínez-Micaelo, Raúl Beltrán-Debón, Isabel Baiges, Marta Faiges and Josep M. Alegret

    Citation: Journal of Translational Medicine 2017 15:76

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  2. Content type: Research

    Congenital heart disease (CHD) is a common birth defect, and most cases occur sporadically. Mutations in key genes that are responsible for cardiac development could contribute to CHD. To date, the genetic cau...

    Authors: Yanyan Qian, Deyong Xiao, Xiao Guo, Hongbo Chen, Lili Hao, Xiaojing Ma, Guoying Huang, Duan Ma and Huijun Wang

    Citation: Journal of Translational Medicine 2017 15:69

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  3. Content type: Research

    Cardioprotective value of ischemic post- (IPostC), remote (RIC) conditioning in acute myocardial infarction (AMI) is unclear in clinical trials. To evaluate cardioprotection, most translational animal studies ...

    Authors: Tamás Baranyai, Zoltán Giricz, Zoltán V. Varga, Gábor Koncsos, Dominika Lukovic, András Makkos, Márta Sárközy, Noémi Pávó, András Jakab, Csilla Czimbalmos, Hajnalka Vágó, Zoltán Ruzsa, Levente Tóth, Rita Garamvölgyi, Béla Merkely, Rainer Schulz…

    Citation: Journal of Translational Medicine 2017 15:67

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  4. Content type: Research

    We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk ...

    Authors: Ze-Bang Lin, Hong-Bo Ci, Yan Li, Tian-Pu Cheng, Dong-Hong Liu, Yan-Sheng Wang, Jun Xu, Hao-Xiang Yuan, Hua-Ming Li, Jing Chen, Li Zhou, Zhi-Ping Wang, Xi Zhang, Zhi-Jun Ou and Jing-Song Ou

    Citation: Journal of Translational Medicine 2017 15:4

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  5. Content type: Research

    Thyroid hormones have been associated with renal dysfunction in cross-sectional studies. However, prospective studies exploring the effect of thyroid hormones on renal function decline were sparse and got cont...

    Authors: Xiaolin Huang, Lin Ding, Kui Peng, Lin Lin, Tiange Wang, Zhiyun Zhao, Yu Xu, Jieli Lu, Yuhong Chen, Weiqing Wang, Yufang Bi, Guang Ning and Min Xu

    Citation: Journal of Translational Medicine 2016 14:336

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  6. Content type: Research

    Cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) near chromosome 9p21 have been associated with both atherosclerosis and artery calcification, but the underlying mechanisms remained largely unknown. Considerin...

    Authors: Shuyu Zhou, Yumeng Zhang, Li Wang, Zhizhong Zhang, Biyang Cai, Keting Liu, Hao Zhang, Minhui Dai, Lingli Sun, Xiaomeng Xu, Huan Cai, Xinfeng Liu, Guangming Lu and Gelin Xu

    Citation: Journal of Translational Medicine 2016 14:333

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  7. Content type: Research

    Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechani...

    Authors: Farid Boubred, Laurent Daniel, Christophe Buffat, Michel Tsimaratos, Charles Oliver, Martine Lelièvre-Pégorier and Umberto Simeoni

    Citation: Journal of Translational Medicine 2016 14:331

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  8. Content type: Review

    Cardiovascular diseases (CVD) are an important cause of death worldwide. Anthocyanins are a subgroup of flavonoids found in berries, flowers, fruits and leaves. In epidemiological and clinical studies, these p...

    Authors: Jordano Ferreira Reis, Valter Vinicius Silva Monteiro, Rafaelli de Souza Gomes, Matheus Moraes do Carmo, Glauber Vilhena da Costa, Paula Cardoso Ribera and Marta Chagas Monteiro

    Citation: Journal of Translational Medicine 2016 14:315

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  9. Content type: Research

    Angiopoietin-2 (Ang-2), a ligand of the Tie-2 receptor, plays an important role in maintaining endothelial cells and in destabilizing blood vessels. Collateral artery growth (arteriogenesis) is a key adaptive ...

    Authors: Xiaoyong Tan, Kai Yan, Meiping Ren, Ni Chen, Yongjie Li, Xin Deng, Liqun Wang, Rong Li, Mao Luo, Yong Liu, Yan Liu and Jianbo Wu

    Citation: Journal of Translational Medicine 2016 14:306

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  10. Content type: Research

    Previous studies have suggested that people with obesity showed elevated serum levels of leptin as well as lipid dysfunction and proprotein convertase subtilisin/kexin type 9 (PCSK9) played an important role i...

    Authors: Ying Du, Sha Li, Chuan-Jue Cui, Yan Zhang, Sheng-Hua Yang and Jian-Jun Li

    Citation: Journal of Translational Medicine 2016 14:276

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  11. Content type: Review

    Research and development of new drugs requires both long time and high costs, whereas safety and tolerability profiles make the success rate of approval very low. Drug repurposing, applying known drugs and com...

    Authors: Junichi Ishida, Masaaki Konishi, Nicole Ebner and Jochen Springer

    Citation: Journal of Translational Medicine 2016 14:269

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  12. Content type: Research

    Urtica dioica has traditionally been used in the management of cardiovascular disorders especially hypertension. The aim of this study was to explore pharmacological base of its use in...

    Authors: Rahila Qayyum, Hafiz Misbah-ud-Din Qamar, Shamim Khan, Umme Salma, Taous Khan and Abdul Jabbar Shah

    Citation: Journal of Translational Medicine 2016 14:254

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  13. Content type: Research

    Understanding the underlying mechanism of thrombus formation and its components is critical for effective prevention and treatment of ischemic stroke. The generation of thrombotic clots requires conversion of ...

    Authors: Slaven Pikija, Vladimir Trkulja, Johannes Sebastian Mutzenbach, Mark R. McCoy, Patricia Ganger and Johann Sellner

    Citation: Journal of Translational Medicine 2016 14:250

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  14. Content type: Research

    Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary ar...

    Authors: Inmaculada Moreno-Santos, Luis Miguel Pérez-Belmonte, Manuel Macías-González, María José Mataró, Daniel Castellano, Miguel López-Garrido, Carlos Porras-Martín, Pedro L. Sánchez-Fernández, Juan José Gómez-Doblas, Fernando Cardona, Eduardo de Teresa-Galván and Manuel Jiménez-Navarro

    Citation: Journal of Translational Medicine 2016 14:243

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  15. Content type: Research

    The Wellcome Trust, the World Health Organization, and cardiologists have advocated for the idea of a “polypill” containing multiple cardiovascular drugs to be co-formulated into a single pill for over a decad...

    Authors: Reed F. Beall, Jon-David R. Schwalm, Mark D. Huffman, Tara McCready, Salim Yusuf and Amir Attaran

    Citation: Journal of Translational Medicine 2016 14:242

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  16. Content type: Research

    Hyperlipidemia is a major component of metabolic syndrome, and often predicts cardiovascular diseases. We developed a new therapeutic agent berberine compounds (BC), consisting of berberine, oryzanol and vitam...

    Authors: Meng Li, Xiangbing Shu, Hanchen Xu, Chunlei Zhang, Lili Yang, Li Zhang and Guang Ji

    Citation: Journal of Translational Medicine 2016 14:237

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  17. Content type: Research

    Intra-operative cell salvage (CS) was reported to have no impairment on blood coagulation in low-bleeding-risk cardiac surgery with cardiopulmonary bypass (CPB), but studies in high-bleeding-risk cardiac surge...

    Authors: Sheliang Shen, Jun Zhang, Wenyuan Wang, Jiayin Zheng and Yihong Xie

    Citation: Journal of Translational Medicine 2016 14:228

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  18. Content type: Research

    Psoriasis is a chronic inflammatory disease of the skin and joints that may also have systemic inflammatory effects, including the development of cardiovascular disease (CVD). Multiple epidemiologic studies ha...

    Authors: S. Santilli, D. R. Kast, I. Grozdev, L. Cao, R. L. Feig, J. B. Golden, S. M. Debanne, R. C. Gilkeson, C. E. Orringer, T. S. McCormick, N. L. Ward, K. D. Cooper and N. J. Korman

    Citation: Journal of Translational Medicine 2016 14:217

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  19. Content type: Research

    Endothelial dysfunction associated with hypercholesterolemia is an early event in atherosclerosis characterized by redox imbalance associated with high superoxide production and reduced nitric oxide (NO) and h...

    Authors: Daniele M. Guizoni, Gabriel G. Dorighello, Helena C. F. Oliveira, Maria A. Delbin, Marta H. Krieger and Ana P. Davel

    Citation: Journal of Translational Medicine 2016 14:213

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  20. Content type: Research

    Aspirin (ASA) is the most widely used medicine to prevent cardiovascular diseases; however, the mechanisms by which ASA exerts its anti-proliferative effect remain not fully understood. This study was designed...

    Authors: Xin Guo, Lijin Yu, Min Chen, Tian Wu, Xiangdong Peng, Ren Guo and Bikui Zhang

    Citation: Journal of Translational Medicine 2016 14:211

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  21. Content type: Research

    Macrophages play important roles in adipose tissue inflammation and its consequences. Unfortunately, a detailed description of the macrophage phenotypes in different human adipose tissues is not available.

    Authors: Ivana Kralova Lesna, Anna Kralova, Sona Cejkova, Jiri Fronek, Marek Petras, Alena Sekerkova, Filip Thieme, Libor Janousek and Rudolf Poledne

    Citation: Journal of Translational Medicine 2016 14:208

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  22. Content type: Research

    Long noncoding RNAs (lncRNAs) are non-protein coding transcripts regulating a variety of physiological and pathological functions. However, their implication in heart failure is still largely unknown. The aim ...

    Authors: Simona Greco, Germana Zaccagnini, Alessandra Perfetti, Paola Fuschi, Rea Valaperta, Christine Voellenkle, Serenella Castelvecchio, Carlo Gaetano, Nicoletta Finato, Antonio Paolo Beltrami, Lorenzo Menicanti and Fabio Martelli

    Citation: Journal of Translational Medicine 2016 14:183

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  23. Content type: Research

    Differentially expressed genes in the left atria of mitral regurgitation (MR) pigs have been linked to peroxisome proliferator-activated receptor (PPAR) signaling pathway in the KEGG pathway. However, specific...

    Authors: Mien-Cheng Chen, Jen-Ping Chang, Yu-Sheng Lin, Kuo-Li Pan, Wan-Chun Ho, Wen-Hao Liu, Tzu-Hao Chang, Yao-Kuang Huang, Chih-Yuan Fang and Chien-Jen Chen

    Citation: Journal of Translational Medicine 2016 14:157

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  24. Content type: Research

    Hemodynamic load leads to cardiac hypertrophy and heart failure. While afterload (pressure overload) induces concentric hypertrophy, elevation of preload (volume overload) yields eccentric hypertrophy and is a...

    Authors: Belal A. Mohamed, Abdul R. Asif, Moritz Schnelle, Mohamed Qasim, Sara Khadjeh, Dawid Lbik, Peter Schott, Gerd Hasenfuss and Karl Toischer

    Citation: Journal of Translational Medicine 2016 14:149

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  25. Content type: Methodology

    Integration of whole-heart activation simulations and inverse potential mapping (IPM) could benefit the guidance and planning of electrophysiological procedures. Routine clinical application requires a fast an...

    Authors: P. Bhagirath, A. W. M. van der Graaf, J. de Hooge, N. M. S. de Groot and M. J. W. Götte

    Citation: Journal of Translational Medicine 2016 14:147

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  26. Content type: Research

    To investigate whether vascular endothelial growth factor B (VEGF-B) improves myocardial survival and cardiac stem cell (CSC) function in the ischemia–reperfusion (I/R) heart and promotes CSC mobilization and ...

    Authors: Guo-hua Li, Bin Luo, Yan-xia Lv, Fei Zheng, Lu Wang, Meng-xi Wei, Xian-yu Li, Lei Zhang, Jia-ning Wang, Shi-you Chen, Jun-Ming Tang and Xiaohua He

    Citation: Journal of Translational Medicine 2016 14:116

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  27. Content type: Research

    Thoracic aortic aneurysms and dissections (TAAD) are silent but possibly lethal condition with up to 40 % of cases being hereditary. Genetic background is heterogeneous. Recently next-generation sequencing ena...

    Authors: J. K. Poninska, Z. T. Bilinska, M. Franaszczyk, E. Michalak, M. Rydzanicz, E. Szpakowski, A. Pollak, B. Milanowska, G. Truszkowska, P. Chmielewski, A. Sioma, H. Janaszek-Sitkowska, A. Klisiewicz, I. Michalowska, M. Makowiecka-Ciesla, P. Kolsut…

    Citation: Journal of Translational Medicine 2016 14:115

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  28. Content type: Research

    The prevalence of hyperuricemia has increased dramatically during the past several decades. Studies indicating uric acid is an independent risk factor for hypertension did not sufficiently control for other kn...

    Authors: Fengjiang Wei, Ning Sun, Chunyou Cai, Shuzhi Feng, Jianli Tian, Wentao Shi, Weili Xu, Yaogang Wang, Xilin Yang and Wei-Dong Li

    Citation: Journal of Translational Medicine 2016 14:110

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  29. Content type: Research

    Mammalian microRNAs (miR) regulate the expression of genes relevant for the development of adaptive and innate immunity against cancer. Since T cell dysfunction has previously been reported in patients with re...

    Authors: Margherita Gigante, Paola Pontrelli, Wolfgang Herr, Maddalena Gigante, Morena D’Avenia, Gianluigi Zaza, Elisabetta Cavalcanti, Matteo Accetturo, Giuseppe Lucarelli, Giuseppe Carrieri, Michele Battaglia, Walter J. Storkus, Loreto Gesualdo and Elena Ranieri

    Citation: Journal of Translational Medicine 2016 14:84

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  30. Content type: Research

    Energy metabolism disorder is a critical process in lung ischemia–reperfusion injury (LIRI). This study was aimed to determine the effects of resolvin D1 (RvD1) on the energy metabolism in LIRI.

    Authors: Qifeng Zhao, Ji Wu, Qingwang Hua, Zhiyong Lin, Leping Ye, Weixi Zhang, Guowei Wu, Jie Du, Jie Xia, Maoping Chu and Xingti Hu

    Citation: Journal of Translational Medicine 2016 14:81

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  31. Content type: Research

    To explore whether plasma fatty acids and SNPs in the fatty acid desaturase (FADS) gene associated with type 2 diabetes (T2D) and coronary artery disease (CAD).

    Authors: Si-Wei Li, Jin Wang, Ying Yang, Zhi-Jie Liu, Lin Cheng, Huan-Yu Liu, Pei Ma, Wan Luo and Song-Mei Liu

    Citation: Journal of Translational Medicine 2016 14:79

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  32. Content type: Research

    Aspirin resistance established by different laboratory methods is still a debated problem. Using COX1 specific methods no aspirin resistance was detected among healthy volunteers. Here we tested the effect of ...

    Authors: Nóra Homoródi, Emese G. Kovács, Sarolta Leé, Éva Katona, Amir H. Shemirani, Gizella Haramura, László Balogh, Zsuzsanna Bereczky, Gabriella Szőke, Hajna Péterfy, Róbert G. Kiss, István Édes and László Muszbek

    Citation: Journal of Translational Medicine 2016 14:74

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  33. Content type: Research

    Lower leg ischemia, myopathy, and limb dysfunction are distinguishing features of peripheral artery disease (PAD). The myopathy of PAD is characterized by myofiber degeneration in association with extracellula...

    Authors: Duy M. Ha, Lauren C. Carpenter, Panagiotis Koutakis, Stanley A. Swanson, Zhen Zhu, Mina Hanna, Holly K. DeSpiegelaere, Iraklis I. Pipinos and George P. Casale

    Citation: Journal of Translational Medicine 2016 14:39

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  34. Content type: Research

    Endothelial progenitor cells (EPCs) contribute to recanalization of deep vein thrombosis (DVT). This study aimed to detect miRNA expression profiles in EPCs from patients with DVT and characterize the role of ...

    Authors: Lingshang Kong, Nan Hu, Xiaolong Du, Wenbin Wang, Hong Chen, Wendong Li, Sen Wei, Hao Zhuang, Xiaoqiang Li and Chenglong Li

    Citation: Journal of Translational Medicine 2016 14:23

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  35. Content type: Research

    Heart failure with ejection fraction (HFpEF) is a syndrome resulting from several co-morbidities in which specific mediators are unknown. The platelet proteome responds to disease processes. We hypothesize tha...

    Authors: Roseanne Raphael, Diana Purushotham, Courtney Gastonguay, Marla A. Chesnik, Wai-Meng Kwok, Hsiang-En Wu, Sanjiv J. Shah, Shama P. Mirza and Jennifer L. Strande

    Citation: Journal of Translational Medicine 2016 14:18

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  36. Content type: Research

    Psoriasis patients exhibit an increased risk of atherothrombotic events, including myocardial infarction and stroke. Clinical evidence suggests that psoriasis patients with early onset and more severe disease ...

    Authors: Jackelyn B. Golden, Yunmei Wang, Yi Fritz, Doina Diaconu, Xiufen Zhang, Sara M. Debanne, Daniel I. Simon, Thomas S. McCormick and Nicole L. Ward

    Citation: Journal of Translational Medicine 2015 13:382

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  37. Content type: Research

    XBP1 is a key transcription factor of the unfolded protein response in mammalian cells, which is involved in several cardiovascular pathological progression including cardiac hypertrophy and myocardial infarct...

    Authors: Quanlu Duan, Chen Chen, Lei Yang, Ni Li, Wei Gong, Sheng Li and Dao Wen Wang

    Citation: Journal of Translational Medicine 2015 13:363

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  38. Content type: Research

    Gamma-glutamyltransferase (GGT) is a well-established independent risk factor for cardiovascular mortality related to atherosclerotic disease. Four GGT fractions have been identified in plasma, but only b-GGT ...

    Authors: Eugenia Belcastro, Maria Franzini, Silvana Cianchetti, Evelina Lorenzini, Silvia Masotti, Vanna Fierabracci, Angela Pucci, Alfonso Pompella and Alessandro Corti

    Citation: Journal of Translational Medicine 2015 13:325

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  39. Content type: Research

    Inflammation mediated by nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of hypertensive nephropathy (HN). Cytoskeletal remodelling is necessary for the activation of NF-κB. An actin-bindin...

    Authors: Quan-zhen Wang, Hai-qing Gao, Ying Liang, Jun Zhang, Jian Wang and Jie Qiu

    Citation: Journal of Translational Medicine 2015 13:323

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  40. Content type: Research

    Methionine sulfoxide reductase A (MsrA) is a potent intracellular oxidoreductase and serves as an essential factor that protects cells against oxidative damage. However, therapeutic use of exogenous MsrA in ox...

    Authors: Yao Wu, Guanghui Xie, Yanyong Xu, Li Ma, Chuanfeng Tong, Daping Fan, Fen Du and Hong Yu

    Citation: Journal of Translational Medicine 2015 13:316

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  41. Content type: Research

    Circulating microRNAs may represent novel markers for cardiovascular diseases. We evaluated whether circulating miRNAs served as potential biomarkers for diffuse myocardial fibrosis in patients with hypertroph...

    Authors: Lu Fang, Andris H. Ellims, Xiao-lei Moore, David A. White, Andrew J. Taylor, Jaye Chin-Dusting and Anthony M. Dart

    Citation: Journal of Translational Medicine 2015 13:314

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  42. Content type: Research

    From a pharmacological perspective, readily-available, well-characterized animal models of cardiovascular disease, including relevant in vivo markers of atherosclerosis are important for evaluation of novel dr...

    Authors: Trine Pagh Ludvigsen, Rikke Kaae Kirk, Berit Østergaard Christoffersen, Henrik Duelund Pedersen, Torben Martinussen, Jonas Kildegaard, Peter M. H. Heegaard, Jens Lykkesfeldt and Lisbeth Høier Olsen

    Citation: Journal of Translational Medicine 2015 13:312

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  43. Content type: Research

    Energy loss (EL) was regarded to be one of the key parameters in predicting the rupture risk of IA. In this paper, we took varied aspect ratio (AR) as a scaling law to create a series of longitudinal models to...

    Authors: Yunling Long, Jingru Zhong, Hongyu Yu, Huagang Yan, Zhizheng Zhuo, Qianqian Meng, Xinjian Yang and Haiyun Li

    Citation: Journal of Translational Medicine 2015 13:311

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  44. Content type: Research

    Heart failure (HF) is characterized by a series of adaptive changes in energy metabolism. The use of metabolomics enables the parallel assessment of a wide range of metabolites. In this study, we appraised whe...

    Authors: Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Emanuela Locci, Luigi Barberini, Federica Torri, Federica Ascedu, Luigi Atzori and Giuseppe Mercuro

    Citation: Journal of Translational Medicine 2015 13:297

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  46. Content type: Research

    Apelin is an endogenous ligand for the G protein-coupled receptor APJ. The association between apelin and cardiac modeling has been reported. However, if serum apelin affect the left ventricular hypertrophy (L...

    Authors: Lijun Ye, Fenghua Ding, Liang Zhang, Anna Shen, Huaguo Yao, Liehua Deng and Yuanlin Ding

    Citation: Journal of Translational Medicine 2015 13:290

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  47. Content type: Research

    Berberine (BBR), as a new medicine for hyperlipidemia, can reduce the blood lipids in patients. Mechanistic studies have shown that BBR activates the extracellular-signal regulated kinase pathway by stabilizin...

    Authors: Xiao-Yang Li, Zhen-Xiong Zhao, Min Huang, Ru Feng, Chi-Yu He, Chao Ma, Shi-Heng Luo, Jie Fu, Bao-Ying Wen, Long Ren, Jia-Wen Shou, Fang Guo, Yangchao Chen, Xin Gao, Yan Wang and Jian-Dong Jiang

    Citation: Journal of Translational Medicine 2015 13:278

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  48. Content type: Research

    The aim of this study was to assess the relationship between extracorporeal blood flow (EBF) and left ventricular (LV) performance during venoarterial extracorporeal membrane oxygenation (VA ECMO) therapy.

    Authors: Petr Ostadal, Mikulas Mlcek, Andreas Kruger, Pavel Hala, Stanislav Lacko, Martin Mates, Dagmar Vondrakova, Tomas Svoboda, Matej Hrachovina, Marek Janotka, Hana Psotova, Svitlana Strunina, Otomar Kittnar and Petr Neuzil

    Citation: Journal of Translational Medicine 2015 13:266

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  49. Content type: Research

    The renin-angiotensin system (RAS) has been implicated in atherosclerotic lesions and progression to chronic kidney diseases. We examined regulatory roles of angiotensin-converting enzyme 2 (ACE2) in the apoli...

    Authors: Hai-Yan Jin, Lai-Jiang Chen, Zhen-Zhou Zhang, Ying-Le Xu, Bei Song, Ran Xu, Gavin Y Oudit, Ping-Jin Gao, Ding-Liang Zhu and Jiu-Chang Zhong

    Citation: Journal of Translational Medicine 2015 13:255

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  50. Content type: Research

    Metabolic derangement is a key hallmark of major traumatic injury. The recent introduction of mass spectrometry-based metabolomics technologies in the field of trauma shed new light on metabolic aberrations in...

    Authors: Angelo D’Alessandro, Annie L Slaughter, Erik D Peltz, Ernest E Moore, Christopher C Silliman, Matthew Wither, Travis Nemkov, Anthony W Bacon, Miguel Fragoso, Anirban Banerjee and Kirk C Hansen

    Citation: Journal of Translational Medicine 2015 13:253

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