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Cardiovascular, Metabolic and Lipoprotein Translation

Section edited by Nehal N. Mehta and Tommaso Angelone
© Juan Gärtner/ stock.adob

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

Featured articles


Immune cell phenotyping in low blood volumes for assessment of cardiovascular disease risk, development, and progression: a pilot study

Research | Yvonne Baumer et al


Comprehensive analysis of differential immunocyte infiltration and the potential ceRNA networks during epicardial adipose tissue development in congenital heart disease

Research | Li Ma et al


Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration​​​​​​​

Research | Sharon F Wu et al

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  1. Aortic aneurysm (AA) is defined as an enlargement of the aorta greater than 1.5 times its normal size. Early diagnosis of AA is challenging and mortality of AA is high. Curative pharmacological treatments for ...

    Authors: Zhao Cheng, Yang-zhao Zhou, Yin Wu, Qi-ying Wu, Xiao-bo Liao, Xian-ming Fu and Xin-min Zhou
    Citation: Journal of Translational Medicine 2018 16:354
    Content type: Review Published on:

  2. To date the TGF-β1 activation mediated by integrin ανβ5 during fibrosis is well-known. This process has been shown also in the heart, where cardiac fibroblasts (CF) differentiate into α-smooth muscle actin (α-...

    Authors: Gianluca Lorenzo Perrucci, Veronica Antonietta Barbagallo, Maria Corlianò, Delfina Tosi, Rosaria Santoro, Patrizia Nigro, Paolo Poggio, Gaetano Bulfamante, Federico Lombardi and Giulio Pompilio
    Citation: Journal of Translational Medicine 2018 16:352
    Content type: Research Published on:

  3. Patients with monogenic familial hypercholesterolemia (FH) have high risk for coronary artery disease (CAD). A recent FH Expert Panel suggested that FH was underdiagnosed and undertreated which needs early dia...

    Authors: Ye-Xuan Cao, Na-Qiong Wu, Di Sun, Hui-Hui Liu, Jing-Lu Jin, Sha Li, Yuan-Lin Guo, Cheng-Gang Zhu, Ying Gao, Qiu-Ting Dong, Geng Liu, Qian Dong and Jian-Jun Li
    Citation: Journal of Translational Medicine 2018 16:345
    Content type: Research Published on:

  4. Metabolic syndrome (MetS) has an increased prevalence (approximately 20–25% of the adult population) all over the world. Immunological function is significantly associated with the development of MetS, and Met...

    Authors: Shihui Fu, Yao Yao, Faqin Lv, Fu Zhang, Yali Zhao and Fuxin Luan
    Citation: Journal of Translational Medicine 2018 16:315
    Content type: Research Published on:

  5. Sirtuin 3 (Sirt3) is a key regulator of energy metabolism and oxidative stress. To investigate the role of Sirt3 in contrast-induced acute kidney injury (CIAKI), we established the model both in vivo and in vi...

    Authors: Qinghai Zhang, Xun Liu, Na li, Jihong Zhang, Jianmin Yang and Peili Bu
    Citation: Journal of Translational Medicine 2018 16:313
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2022 20:46

  6. To examine serum angiopoietin-2 (Angpt-2) in relation to malnutrition, inflammation, atherosclerosis and cardiac valvular calcification, so-called MIAC syndrome and its predictive role in outcomes of peritonea...

    Authors: Xiaoxiao Yang, He Zhang, Yuanyuan Shi, Zanzhe Yu, Hao Yan, Zhaohui Ni, Jiaqi Qian and Wei Fang
    Citation: Journal of Translational Medicine 2018 16:312
    Content type: Research Published on:

  7. Scavenger receptor class B type 1 (SR-B1) plays an essential role in high density lipoprotein (HDL) metabolism. SR-B1 deficient (SR-B1 KO) mice are prone to atherosclerosis and exhibit abnormally large, choles...

    Authors: Susana Contreras-Duarte, Nicolás Santander, Ruth Birner-Gruenberger, Christian Wadsack, Attilio Rigotti and Dolores Busso
    Citation: Journal of Translational Medicine 2018 16:309
    Content type: Commentary Published on:

  8. Cardiac resynchronization therapy (CRT) reduces symptoms, morbidity and mortality in chronic heart failure patients with wide QRS complexes. However, approximately one third of CRT patients are non-responders....

    Authors: Clémentine Andre, Eric Piver, Romain Perault, Arnaud Bisson, Julien Pucheux, Emmanuelle Vermes, Bertrand Pierre, Laurent Fauchier, Dominique Babuty and Nicolas Clementy
    Citation: Journal of Translational Medicine 2018 16:299
    Content type: Research Published on:

  9. Doxorubicin (DOX)-based chemotherapy for Hodgkin lymphoma (HL) yields excellent disease-free survival, but poses a substantial risk of subsequent left ventricular (LV) dysfunction and heart failure, typically ...

    Authors: Matteo Sarocchi, Matteo Bauckneht, Eleonora Arboscello, Selene Capitanio, Cecilia Marini, Silvia Morbelli, Maurizio Miglino, Angela Giovanna Congiu, Giorgio Ghigliotti, Manrico Balbi, Claudio Brunelli, Gianmario Sambuceti, Pietro Ameri and Paolo Spallarossa
    Citation: Journal of Translational Medicine 2018 16:295
    Content type: Research Published on:

  10. Conotruncal heart defect (CTD) is a complex congenital heart disease with a complex and poorly understood etiology. The transcriptional corepressor RIPPLY3 plays a pivotal role in heart development as a negati...

    Authors: Nanchao Hong, Erge Zhang, Qingjie Wang, Xiaoqing Zhang, Fen Li, Qihua Fu, Rang Xu, Yu Yu, Sun Chen, Yuejuan Xu and Kun Sun
    Citation: Journal of Translational Medicine 2018 16:260
    Content type: Research Published on:

  11. Cardiomyopathies are the most common clinical and genetic heterogeneity cardiac diseases, and genetic contribution in particular plays a major role in patients with primary cardiomyopathies. The aim of this st...

    Authors: Chaoxia Lu, Wei Wu, Fang Liu, Kunqi Yang, Jiacheng Li, Yaping Liu, Rongrong Wang, Nuo Si, Peng Gao, Yongtai Liu, Shuyang Zhang and Xue Zhang
    Citation: Journal of Translational Medicine 2018 16:241
    Content type: Research Published on:

  12. Individuals with arterial hypertension often have an autonomic nervous system (ANS) imbalance with predominance of sympathetic ANS. This predominance can lead to injury of several organs affecting its function...

    Authors: Arthur F. Vale, Juliana A. Carneiro, Paulo C. V. Jardim, Thiago V. Jardim, James Steele, James P. Fisher and Paulo Gentil
    Citation: Journal of Translational Medicine 2018 16:240
    Content type: Research Published on:

  13. To explore the association between systolic and diastolic blood pressure (SBP and DBP respectively) and pulse pressure (PP) with cardiovascular disease (CVD) and mortality events among Iranian patients with pr...

    Authors: Ashkan Hashemi, Sormeh Nourbakhsh, Samaneh Asgari, Mohammadhassan Mirbolouk, Fereidoun Azizi and Farzad Hadaegh
    Citation: Journal of Translational Medicine 2018 16:230
    Content type: Research Published on:

  14. YKL-40 (CHI3L1) is a novel biomarker for inflammation, tissue remodeling, and fibrosis, as well as cardiovascular diseases. We investigated the association between YKL-40 expression in epicardial adipose tissue (...

    Authors: Qing Wang, Hua Shen, Jie Min, Yang Gao, Kai Liu, Wang Xi, Jie Yang, Liang Yin, Jibin Xu, Jian Xiao and Zhinong Wang
    Citation: Journal of Translational Medicine 2018 16:229
    Content type: Research Published on:

  15. The globally rising obesity epidemic is associated with a broad spectrum of diseases including atherosclerosis and non-alcoholic fatty liver (NAFL) disease. In the past, research focused on the vasculature or ...

    Authors: Erik Taylor, Nasi Huang, Jacob Bodde, Andrew Ellison, Ronald Killiany, Markus Michael Bachschmid and James Hamilton
    Citation: Journal of Translational Medicine 2018 16:215
    Content type: Research Published on:

  16. MicroRNAs (miRNAs) are non-coding RNAs that function as regulators of gene expression and thereby contribute to the complex disease phenotypes. Hypertrophic cardiomyopathy (HCM) and Dilated cardiomyopathy (DCM...

    Authors: Mengmeng Li, Xiao Chen, Liang Chen, Kai Chen, Jianye Zhou and Jiangping Song
    Citation: Journal of Translational Medicine 2018 16:161
    Content type: Research Published on:

  17. Scavenger receptor class B type I (SR-BI) plays a key role in high density lipoproteins (HDL) metabolism. SR-BI deficiency in mice results in enhanced susceptibility to atherosclerosis with abnormal large, cho...

    Authors: Jia Cao, Yanyong Xu, Feifei Li, Liang Shang, Daping Fan and Hong Yu
    Citation: Journal of Translational Medicine 2018 16:155
    Content type: Research Published on:

  18. Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinical studies, performed usin...

    Authors: Solange Moll, Yukari Yasui, Ahmed Abed, Takeshi Murata, Hideaki Shimada, Akira Maeda, Naoshi Fukushima, Masakazu Kanamori, Sabine Uhles, Laura Badi, Thomas Cagarelli, Ivan Formentini, Faye Drawnel, Guy Georges, Tobias Bergauer, Rodolfo Gasser…
    Citation: Journal of Translational Medicine 2018 16:148
    Content type: Research Published on:

  19. Oxidative stress has been linked to heart failure (HF) in humans. Antioxidant-based treatments are often ineffective. Therefore, we hypothesize that some of the HF patients might have a reductive stress (RS) c...

    Authors: Thiagarajan Sairam, Amit N. Patel, Meenu Subrahmanian, Rajendiran Gopalan, Steven M. Pogwizd, Sudha Ramalingam, Ramalingam Sankaran and Namakkal Soorapan Rajasekaran
    Citation: Journal of Translational Medicine 2018 16:130
    Content type: Research Published on:

  20. The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regula...

    Authors: Yanan Jiang, Lu Chai, Moyondafoluwa Blessing Fasae and Yunlong Bai
    Citation: Journal of Translational Medicine 2018 16:121
    Content type: Review Published on:

  21. Preclinical and proof-of-concept studies suggest a cardioprotective effect of remote ischemic preconditioning (RIPC). However, two major clinical trials (ERICCA and RIPHeart) failed to show cardioprotection by...

    Authors: André Heinen, Friederike Behmenburg, Aykut Aytulun, Maximilian Dierkes, Lea Zerbin, Wolfgang Kaisers, Maximilian Schaefer, Tanja Meyer-Treschan, Susanne Feit, Inge Bauer, Markus W. Hollmann and Ragnar Huhn
    Citation: Journal of Translational Medicine 2018 16:112
    Content type: Research Published on:

  22. The aim of this study was to characterize the influence of cardiopulmonary bypass (CPB) on myocardial remodeling in newborns and children.

    Authors: Johannes Petersen, Andrey Kazakov, Michael Böhm, Hans-Joachim Schäfers, Ulrich Laufs and Hashim Abdul-Khaliq
    Citation: Journal of Translational Medicine 2018 16:111
    Content type: Research Published on:

  23. Intermittent hypoxia (IH), a typical character of obstructive sleep apnea (OSA), is related to atherogenesis. However, the role of IH on atherosclerosis (AS) progression and the mechanisms involved remains poo...

    Authors: Xianqin Zeng, Rong Guo, Mei Dong, Julia Zheng, Huili Lin and Huixia Lu
    Citation: Journal of Translational Medicine 2018 16:106
    Content type: Research Published on:

  24. Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic ...

    Authors: Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen and Jing-Feng Wang
    Citation: Journal of Translational Medicine 2018 16:105
    Content type: Research Published on:

  25. Cardiovascular disease (CVD) describes the pathological conditions of the heart and blood vessels. Despite the large number of studies on CVD and its etiology, its key modulators remain largely unknown. To thi...

    Authors: Vasiliki Lygirou, Agnieszka Latosinska, Manousos Makridakis, William Mullen, Christian Delles, Joost P. Schanstra, Jerome Zoidakis, Burkert Pieske, Harald Mischak and Antonia Vlahou
    Citation: Journal of Translational Medicine 2018 16:104
    Content type: Research Published on:

  26. MicroRNAs (miRNAs) are small RNAs regulating gene expression post-transcriptionally. While acquired changes of miRNA and mRNA profiles in cancer have been extensively studied, little is known about expression ...

    Authors: Masood Abu-Halima, Mustafa Kahraman, Dominic Henn, Tanja Rädle-Hurst, Andreas Keller, Hashim Abdul-Khaliq and Eckart Meese
    Citation: Journal of Translational Medicine 2018 16:60
    Content type: Research Published on:

  27. There is a preponderance of evidence implicating diabetes with increased coronary artery disease (CAD) and calcification (CAC) in human patients with metabolic syndrome (MetS), but the effect of diabetes on CA...

    Authors: Jill K. Badin, Ayeeshik Kole, Benjamin Stivers, Victor Progar, Anisha Pareddy, Mouhamad Alloosh and Michael Sturek
    Citation: Journal of Translational Medicine 2018 16:58
    Content type: Research Published on:

  28. Familial hypercholesterolemia (FH) is a genetic disorder that result in abnormally high low-density lipoprotein cholesterol levels, markedly increased risk of coronary heart disease (CHD) and tendon xanthomas ...

    Authors: Lucía Baila-Rueda, Itziar Lamiquiz-Moneo, Estíbaliz Jarauta, Rocío Mateo-Gallego, Sofía Perez-Calahorra, Victoria Marco-Benedí, Ana M. Bea, Ana Cenarro and Fernando Civeira
    Citation: Journal of Translational Medicine 2018 16:6
    Content type: Research Published on:

  29. Metabolic syndrome (MetS) is a highly prevalent condition that identifies individuals at risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. Prevention of these diseases relies on ear...

    Authors: Michelle D. Robinson, Ina Mishra, Sneha Deodhar, Vipulkumar Patel, Katrina V. Gordon, Raul Vintimilla, Kim Brown, Leigh Johnson, Sid O’Bryant and David P. Cistola
    Citation: Journal of Translational Medicine 2017 15:258
    Content type: Research Published on:

  30. Spondylarthritis (SpA) is an inflammatory rheumatic disease associated with increased incidence of major adverse cardiovascular events (MACEs). Recently, Paramarta et al. proposed the use of the tyrosine kinas...

    Authors: Loukman Omarjee, Vincent Jaquinandi and Guillaume Mahe
    Citation: Journal of Translational Medicine 2017 15:255
    Content type: Review Published on:

  31. Image-guided high intensity focused ultrasound has been used as an extracorporeal cardiac pacing tool and to enhance homing of stem cells to targeted tissues. However, molecular changes in the myocardium after...

    Authors: Kee W. Jang, Tsang-Wei Tu, Matthew E. Nagle, Bobbi K. Lewis, Scott R. Burks and Joseph A. Frank
    Citation: Journal of Translational Medicine 2017 15:252
    Content type: Research Published on:

  32. GlycA is a novel spectroscopic marker of systemic inflammation with low intra-individual variability and other attributes favoring its clinical use in patients with chronic inflammatory and autoimmune diseases...

    Authors: Margery A. Connelly, James D. Otvos, Irina Shalaurova, Martin P. Playford and Nehal N. Mehta
    Citation: Journal of Translational Medicine 2017 15:219
    Content type: Review Published on:

  33. Ex-vivo normothermic perfusion strategies are a promising new instrument in organ transplantation. The perfusion conditions are designed to be protective however the artificial environment can induce a local i...

    Authors: Sarah A. Hosgood, Tom Moore, Theresa Kleverlaan, Tom Adams and Michael L. Nicholson
    Citation: Journal of Translational Medicine 2017 15:216
    Content type: Research Published on:

  34. Renal denervation (RDN) is a promising therapeutic method in cardiology. Its currently most investigated indication is resistant hypertension. Other potential indications are atrial fibrillation, type 2 diabet...

    Authors: Jean-Claude Lubanda, Miroslav Chochola, Mikuláš Mlček, Petr Neužil, Josef Marek, Štěpán Havránek, Sylvie Kuchynková, Zdeňka Fingrová, Kao-Hsuan Aimee Huang and Aleš Linhart
    Citation: Journal of Translational Medicine 2017 15:215
    Content type: Research Published on:

  35. Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs.

    Authors: Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser…
    Citation: Journal of Translational Medicine 2017 15:202
    Content type: Research Published on:

  36. MicroRNAs (miRNAs) are a class of regulatory RNAs that regulate gene expression post-transcriptionally. Little, however, is known on the expression profile of circulating miRNAs in Tetralogy of Fallot (TOF) pa...

    Authors: Masood Abu-Halima, Eckart Meese, Andreas Keller, Hashim Abdul-Khaliq and Tanja Rädle-Hurst
    Citation: Journal of Translational Medicine 2017 15:156
    Content type: Research Published on:

  37. Regular physical activity is recommended for patients with chronic heart failure to improve their functional capacity, and walking is a popular, effective, and safe form of physical activity. Pedometers have s...

    Authors: Tomas Vetrovsky, Michal Siranec, Jiri Parenica, Martin Griva, Jiri Stastny, Jan Precek, Radek Pelouch, Vaclav Bunc, Ales Linhart and Jan Belohlavek
    Citation: Journal of Translational Medicine 2017 15:153
    Content type: Protocol Published on:

  38. Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Pancreas or islet transplantation has been reported to prevent the development of DN lesions and ameliorate or reverse existing glo...

    Authors: Yongwei Jiang, Wenjian Zhang, Shiqing Xu, Hua Lin, Weiguo Sui, Honglin Liu, Liang Peng, Qing Fang, Li Chen and Jinning Lou
    Citation: Journal of Translational Medicine 2017 15:147
    Content type: Research Published on:

  39. Radiolabeled RGD peptides detect αvβ3 integrin expression associated with angiogenesis and extracellular matrix remodeling after myocardial infarction. We studied whether cardiac positron emission tomography (PET...

    Authors: Maria Grönman, Miikka Tarkia, Tuomas Kiviniemi, Paavo Halonen, Antti Kuivanen, Timo Savunen, Tuula Tolvanen, Jarmo Teuho, Meeri Käkelä, Olli Metsälä, Mikko Pietilä, Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Anne Roivainen and Antti Saraste
    Citation: Journal of Translational Medicine 2017 15:144
    Content type: Research Published on:

  40. The endothelium is a key variable in the pathogenesis of atherosclerosis and its complications, particularly coronary artery disease (CAD). Current evidence suggests that the endothelial status can be regarded...

    Authors: Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Damiana Congia, Emanuela Locci, Federica Ascedu, Gianfranco De Candia, Mauro Cadeddu, Giorgio Lai, Raimondo Pirisi, Luigi Atzori and Giuseppe Mercuro
    Citation: Journal of Translational Medicine 2017 15:112
    Content type: Research Published on:

  41. The lack of early diagnosis, progression markers and effective pharmacological treatment has dramatic unfavourable effects on clinical outcomes in patients with peripheral artery disease (PAD). Addressing thes...

    Authors: Giorgio Aquila, Cinzia Fortini, Antonio Pannuti, Serena Delbue, Micaela Pannella, Marco Bruno Morelli, Cristiana Caliceti, Fausto Castriota, Monica de Mattei, Alessia Ongaro, Agnese Pellati, Pasquale Ferrante, Lucio Miele, Luigi Tavazzi, Roberto Ferrari, Paola Rizzo…
    Citation: Journal of Translational Medicine 2017 15:98
    Content type: Research Published on:

  42. A series of clinical trials have confirmed the correlation between vascular calcification (VC) and cardiovascular events and mortality. However, current treatments have little effects on the regression of VC. ...

    Authors: Adham Sameer A. Bardeesi, Jingwei Gao, Kun Zhang, Suntian Yu, Mengchao Wei, Pinming Liu and Hui Huang
    Citation: Journal of Translational Medicine 2017 15:95
    Content type: Review Published on:

  43. Cell loss and subsequent deterioration of contractile function are hallmarks of chronic heart failure (HF). While apoptosis has been investigated as a participant in the progression of HF, it is unlikely that ...

    Authors: Adrián Szobi, Eva Gonçalvesová, Zoltán V. Varga, Przemyslaw Leszek, Mariusz Kuśmierczyk, Michal Hulman, Ján Kyselovič, Péter Ferdinandy and Adriana Adameová
    Citation: Journal of Translational Medicine 2017 15:86
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:103

  44. Hypertrophic cardiomyopathy (HCM) patients with early repolarization (ER) pattern are at higher risk of ventricular arrhythmia, yet the genetic background of this situation has not been well investigated. Here...

    Authors: Yanhong Chen, Hector Barajas-Martinez, Dongxiao Zhu, Xihui Wang, Chonghao Chen, Ruijuan Zhuang, Jingjing Shi, Xueming Wu, Yijia Tao, Weidong Jin, Xiaoyan Wang and Dan Hu
    Citation: Journal of Translational Medicine 2017 15:78
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:101

  45. We aimed to determine the circulating miRNA expression profile associated with BAV and aortic dilation to provide diagnostic and prognostic biomarkers for BAV and/or aortic dilation.

    Authors: Neus Martínez-Micaelo, Raúl Beltrán-Debón, Isabel Baiges, Marta Faiges and Josep M. Alegret
    Citation: Journal of Translational Medicine 2017 15:76
    Content type: Research Published on:

  46. Congenital heart disease (CHD) is a common birth defect, and most cases occur sporadically. Mutations in key genes that are responsible for cardiac development could contribute to CHD. To date, the genetic cau...

    Authors: Yanyan Qian, Deyong Xiao, Xiao Guo, Hongbo Chen, Lili Hao, Xiaojing Ma, Guoying Huang, Duan Ma and Huijun Wang
    Citation: Journal of Translational Medicine 2017 15:69
    Content type: Research Published on:

  47. Cardioprotective value of ischemic post- (IPostC), remote (RIC) conditioning in acute myocardial infarction (AMI) is unclear in clinical trials. To evaluate cardioprotection, most translational animal studies ...

    Authors: Tamás Baranyai, Zoltán Giricz, Zoltán V. Varga, Gábor Koncsos, Dominika Lukovic, András Makkos, Márta Sárközy, Noémi Pávó, András Jakab, Csilla Czimbalmos, Hajnalka Vágó, Zoltán Ruzsa, Levente Tóth, Rita Garamvölgyi, Béla Merkely, Rainer Schulz…
    Citation: Journal of Translational Medicine 2017 15:67
    Content type: Research Published on:

  48. We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk ...

    Authors: Ze-Bang Lin, Hong-Bo Ci, Yan Li, Tian-Pu Cheng, Dong-Hong Liu, Yan-Sheng Wang, Jun Xu, Hao-Xiang Yuan, Hua-Ming Li, Jing Chen, Li Zhou, Zhi-Ping Wang, Xi Zhang, Zhi-Jun Ou and Jing-Song Ou
    Citation: Journal of Translational Medicine 2017 15:4
    Content type: Research Published on:

  49. Thyroid hormones have been associated with renal dysfunction in cross-sectional studies. However, prospective studies exploring the effect of thyroid hormones on renal function decline were sparse and got cont...

    Authors: Xiaolin Huang, Lin Ding, Kui Peng, Lin Lin, Tiange Wang, Zhiyun Zhao, Yu Xu, Jieli Lu, Yuhong Chen, Weiqing Wang, Yufang Bi, Guang Ning and Min Xu
    Citation: Journal of Translational Medicine 2016 14:336
    Content type: Research Published on:

  50. Cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) near chromosome 9p21 have been associated with both atherosclerosis and artery calcification, but the underlying mechanisms remained largely unknown. Considerin...

    Authors: Shuyu Zhou, Yumeng Zhang, Li Wang, Zhizhong Zhang, Biyang Cai, Keting Liu, Hao Zhang, Minhui Dai, Lingli Sun, Xiaomeng Xu, Huan Cai, Xinfeng Liu, Guangming Lu and Gelin Xu
    Citation: Journal of Translational Medicine 2016 14:333
    Content type: Research Published on:
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