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Section edited by Nehal N. Mehta
This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.
Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.
Transforming growth factor-beta 1 produced by vascular smooth muscle cells predicts fibrosis in the gastrocnemius of patients with peripheral artery disease
Duy M. Ha, et alCombining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction
Roseanne Raphael, et alChronic, not acute, skin-specific inflammation promotes thrombosis in psoriasis murine models.
Jackelyn B. Golden, et al
Research
Urtica dioica has traditionally been used in the management of cardiovascular disorders especially hypertension. The aim of this study was to explore pharmacological base of its use in...
Journal of Translational Medicine 2016 14:254
Published on: 1 September 2016
Research
Understanding the underlying mechanism of thrombus formation and its components is critical for effective prevention and treatment of ischemic stroke. The generation of thrombotic clots requires conversion of ...
Journal of Translational Medicine 2016 14:250
Published on: 30 August 2016
Research
Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary ar...
Journal of Translational Medicine 2016 14:243
Published on: 19 August 2016
Research
The Wellcome Trust, the World Health Organization, and cardiologists have advocated for the idea of a “polypill” containing multiple cardiovascular drugs to be co-formulated into a single pill for over a decad...
Journal of Translational Medicine 2016 14:242
Published on: 18 August 2016
Research
Hyperlipidemia is a major component of metabolic syndrome, and often predicts cardiovascular diseases. We developed a new therapeutic agent berberine compounds (BC), consisting of berberine, oryzanol and vitam...
Journal of Translational Medicine 2016 14:237
Published on: 5 August 2016
Research
Intra-operative cell salvage (CS) was reported to have no impairment on blood coagulation in low-bleeding-risk cardiac surgery with cardiopulmonary bypass (CPB), but studies in high-bleeding-risk cardiac surge...
Journal of Translational Medicine 2016 14:228
Published on: 29 July 2016
Research
Psoriasis is a chronic inflammatory disease of the skin and joints that may also have systemic inflammatory effects, including the development of cardiovascular disease (CVD). Multiple epidemiologic studies ha...
Journal of Translational Medicine 2016 14:217
Published on: 22 July 2016
Research
Endothelial dysfunction associated with hypercholesterolemia is an early event in atherosclerosis characterized by redox imbalance associated with high superoxide production and reduced nitric oxide (NO) and h...
Journal of Translational Medicine 2016 14:213
Published on: 19 July 2016
Research
Aspirin (ASA) is the most widely used medicine to prevent cardiovascular diseases; however, the mechanisms by which ASA exerts its anti-proliferative effect remain not fully understood. This study was designed...
Journal of Translational Medicine 2016 14:211
Published on: 13 July 2016
Research
Macrophages play important roles in adipose tissue inflammation and its consequences. Unfortunately, a detailed description of the macrophage phenotypes in different human adipose tissues is not available.
Journal of Translational Medicine 2016 14:208
Published on: 11 July 2016
Research
Long noncoding RNAs (lncRNAs) are non-protein coding transcripts regulating a variety of physiological and pathological functions. However, their implication in heart failure is still largely unknown. The aim ...
Journal of Translational Medicine 2016 14:183
Published on: 18 June 2016
Research
Differentially expressed genes in the left atria of mitral regurgitation (MR) pigs have been linked to peroxisome proliferator-activated receptor (PPAR) signaling pathway in the KEGG pathway. However, specific...
Journal of Translational Medicine 2016 14:157
Published on: 2 June 2016
Research
Hemodynamic load leads to cardiac hypertrophy and heart failure. While afterload (pressure overload) induces concentric hypertrophy, elevation of preload (volume overload) yields eccentric hypertrophy and is a...
Journal of Translational Medicine 2016 14:149
Published on: 27 May 2016
Methodology
Integration of whole-heart activation simulations and inverse potential mapping (IPM) could benefit the guidance and planning of electrophysiological procedures. Routine clinical application requires a fast an...
Journal of Translational Medicine 2016 14:147
Published on: 25 May 2016
Research
Thoracic aortic aneurysms and dissections (TAAD) are silent but possibly lethal condition with up to 40 % of cases being hereditary. Genetic background is heterogeneous. Recently next-generation sequencing ena...
Journal of Translational Medicine 2016 14:115
Published on: 4 May 2016
Research
To investigate whether vascular endothelial growth factor B (VEGF-B) improves myocardial survival and cardiac stem cell (CSC) function in the ischemia–reperfusion (I/R) heart and promotes CSC mobilization and ...
Journal of Translational Medicine 2016 14:116
Published on: 4 May 2016
Research
The prevalence of hyperuricemia has increased dramatically during the past several decades. Studies indicating uric acid is an independent risk factor for hypertension did not sufficiently control for other kn...
Journal of Translational Medicine 2016 14:110
Published on: 30 April 2016
Research
Mammalian microRNAs (miR) regulate the expression of genes relevant for the development of adaptive and innate immunity against cancer. Since T cell dysfunction has previously been reported in patients with re...
Journal of Translational Medicine 2016 14:84
Published on: 11 April 2016
Research
Energy metabolism disorder is a critical process in lung ischemia–reperfusion injury (LIRI). This study was aimed to determine the effects of resolvin D1 (RvD1) on the energy metabolism in LIRI.
Journal of Translational Medicine 2016 14:81
Published on: 24 March 2016
Research
To explore whether plasma fatty acids and SNPs in the fatty acid desaturase (FADS) gene associated with type 2 diabetes (T2D) and coronary artery disease (CAD).
Journal of Translational Medicine 2016 14:79
Published on: 22 March 2016
