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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. The impact of metabolically healthy obesity (MHO) on kidney dysfunction remains debatable. Moreover, few studies have focused on the early stages of kidney dysfunction indicated by hyperfiltration and mildly r...

    Authors: Hong Zhang, Rui Chen, Xiaohong Xu, Minxing Yang, Wenrong Xu, Shoukui Xiang, Long Wang, Xiaohong Jiang, Fei Hua and Xiaolin Huang
    Citation: Journal of Translational Medicine 2023 21:216
    Content type: Research Published on:

  2. Increased circulating uric acid (UA) concentration may disrupt cardiac function in heart failure patients, but the specific mechanism remains unclear. Here, we postulate that hyperuremia induces sterol regulat...

    Authors: Bowen Lou, Haoyu Wu, Hannes Ott, Katrin Bennewitz, Chen Wang, Gernot Poschet, Hui Liu, Zuyi Yuan, Jens Kroll and Jianqing She
    Citation: Journal of Translational Medicine 2023 21:199
    Content type: Research Published on:

  3. Body mass index (BMI) and lipid parameters are the most commonly used anthropometric parameters and biomarkers for assessing nonalcoholic fatty liver disease (NAFLD) risk. This study aimed to assess and quanti...

    Authors: Song Lu, Qiyang Xie, Maobin Kuang, Chong Hu, Xinghui Li, Huijian Yang, Guotai Sheng, Guobo Xie and Yang Zou
    Citation: Journal of Translational Medicine 2023 21:192
    Content type: Research Published on:

  4. Despite the many signs of progress in pharmacotherapies, metabolic syndrome (MetS) is one of the main public-health burdens worldwide. Our study aimed to compare the effect of breastfeeding (BF) in women with ...

    Authors: Maryam Farahmand, Maryam Rahmati, Fereidoun Azizi and Fahimeh Ramezani Tehrani
    Citation: Journal of Translational Medicine 2023 21:177
    Content type: Research Published on:

  5. Previous studies have reported that high fasting plasma glucose (FPG), even that within the normal range, is associated with the risk of type 2 diabetes (T2D). Nevertheless, these findings are limited to speci...

    Authors: Linfeng He, Wenbin Zheng, Zeyu Li, Lu Chen, Wen Kong and Tianshu Zeng
    Citation: Journal of Translational Medicine 2023 21:175
    Content type: Research Published on:

  6. Type 2 diabetes (T2D) is a critical healthcare challenge and priority in Qatar which is listed amongst the top 10 countries in the world, with its prevalence presently at 17% double the global average. MicroRN...

    Authors: Sahar I. Da’as, Ikhlak Ahmed, Waseem H. Hasan, Doua A. Abdelrahman, Elbay Aliyev, Sabah Nisar, Ajaz Ahmad Bhat, Mugdha V. Joglekar, Anandwardhan A. Hardikar, Khalid A. Fakhro and Ammira S. Al-Shabeeb Akil
    Citation: Journal of Translational Medicine 2023 21:171
    Content type: Research Published on:

  7. The relationship between muscle and prognosis, especially that between muscle distribution across different body parts, and the related prognosis is not well established.

    Authors: Chen-An Liu, Tong Liu, Yi-Zhong Ge, Meng-Meng Song, Guo-Tian Ruan, Shi-Qi Lin, Hai-Lun Xie, Jin-Yu Shi, Xin Zheng, Yue Chen, Liuyi Shen, Li Deng and Han-Ping Shi
    Citation: Journal of Translational Medicine 2023 21:154
    Content type: Research Published on:

  9. Studies focusing on the relationships of adiposity and body shape indices with reproductive factors have reported conflicting results. This study aimed to investigate the influence of reproductive factors on a...

    Authors: Mina Amiri, Maryam Mousavi, Fereidoun Azizi and Fahimeh Ramezani Tehrani
    Citation: Journal of Translational Medicine 2023 21:137
    Content type: Research Published on:

  11. Obesity is accompanied by hormonal, inflammatory and endothelial alterations. These alterations induce a stimulation of several other mechanisms that contribute to the hypertensive state and to increase the ca...

    Authors: Luigi Barrea, Ludovica Verde, Pasquale Santangeli, Stefania Lucà, Annamaria Docimo, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2023 21:128
    Content type: Research Published on:

  12. Computed tomographies (CT) are useful for identifying muscle loss in non-small lung cancer (NSCLC) cachectic patients. However, we lack consensus on the best cutoff point for pectoralis muscle loss. We aimed t...

    Authors: Sarah Santiloni Cury, Diogo de Moraes, Jakeline Santos Oliveira, Paula Paccielli Freire, Patricia Pintor dos Reis, Miguel Luiz Batista Jr, Érica Nishida Hasimoto and Robson Francisco Carvalho
    Citation: Journal of Translational Medicine 2023 21:116
    Content type: Research Published on:

  13. Endometrial cancer (EC) is a common gynecological cancer that endangers women health. Although substantial progresses of EC management have been achieved in recent years, the incidence of EC still remains high...

    Authors: Pengzhu Huang, Xiangqin Fan, Hongfei Yu, Kaiwen Zhang, Huanrong Li, Yingmei Wang and Fengxia Xue
    Citation: Journal of Translational Medicine 2023 21:94
    Content type: Review Published on:

  14. Observational studies have found that both short and long sleep duration are associated with increased risk of metabolic syndrome (MetS). This study aimed to examine the associations of genetically determined ...

    Authors: Yannis Yan Liang, Jie Chen, Miaoguan Peng, Jiajin Zhou, Xinru Chen, Xiao Tan, Ningjian Wang, Huan Ma, Lan Guo, Jihui Zhang, Yun-Kwok Wing, Qingshan Geng and Sizhi Ai
    Citation: Journal of Translational Medicine 2023 21:90
    Content type: Research Published on:

  15. Albumin is the most abundant protein in serum and serves as a transporter of free fatty acids (FFA) in blood vessels. In type 2 diabetes mellitus (T2DM) patients, the reduced serum albumin level is a risk fact...

    Authors: Hongyi Liu, Anji Ju, Xuan Dong, Zongrui Luo, Jiaze Tang, Boyuan Ma, Yan Fu and Yongzhang Luo
    Citation: Journal of Translational Medicine 2023 21:89
    Content type: Research Published on:

  16. Little is known on the association of types of grains with mortality and the moderating effect of lifestyle on this association. This study aims to evaluate the single or joint associations of types of grains ...

    Authors: Yongjie Chen, Boran Sun, Caihong Wang, Keming Zhang, Wenli Lu and Guowei Huang
    Citation: Journal of Translational Medicine 2023 21:88
    Content type: Research Published on:

  17. Diabetic nephropathy (DN) is a complex disease involving the upregulation of many inflammation-related proteins. Alternative polyadenylation (APA), a crucial post-transcriptional regulatory mechanism, has been...

    Authors: Tingting Zhao, Dongdong Zhan, Shuang Qu, Song Jiang, Wenhua Gan, Weisong Qin, Chunxia Zheng, Fang Cheng, Yinghui Lu, Mingwei Liu, Jinsong Shi, Hongwei Liang, Yi Wang, Jun Qin, Ke Zen and Zhihong Liu
    Citation: Journal of Translational Medicine 2023 21:86
    Content type: Research Published on:

  18. Frailty, defined as physical performance impairment, is a common condition in older adults and can anticipate the development of sarcopenia, a geriatric syndrome characterized by loss of muscle strength and ma...

    Authors: Simone Agostini, Roberta Mancuso, Lorenzo Agostino Citterio, Gabriela Alexandra Mihali, Beatrice Arosio and Mario Clerici
    Citation: Journal of Translational Medicine 2023 21:67
    Content type: Research Published on:

  19. Cardiovascular disease (CVD) has evolved into a serious public health issue that demands the use of suitable methods to estimate the risk of the disease. As a result, in a sample of individuals who completed a...

    Authors: Dan Zhao, Hao Sun, Huamin Li, Chaoxiu Li and Bo Zhou
    Citation: Journal of Translational Medicine 2023 21:62
    Content type: Research Published on:

  20. Genetic knowledge of gestational diabetes mellitus (GDM) in Chinese women is quite limited. This study aimed to identify the risk factors and mechanism of GDM at the genetic level in a Chinese population.

    Authors: Miao Zhang, Qing Li, Kai-Lin Wang, Yao Dong, Yu-Tong Mu, Yan-Min Cao, Jin Liu, Zi-Heng Li, Hui-Lu Cui, Hai-Yan Liu, An-Qun Hu and Ying-Jie Zheng
    Citation: Journal of Translational Medicine 2023 21:47
    Content type: Research Published on:

  21. Different metabolic phenotypes may be related to nonalcoholic fatty liver disease (NAFLD), but such association whether modified by serum uric acid levels is unknown. We examined the association between differ...

    Authors: Jun Zheng, Xuerui Li, Yuan Zhang, Yuyang Miao and Qiang Zhang
    Citation: Journal of Translational Medicine 2023 21:39
    Content type: Research Published on:

  22. Very low-calorie ketogenic diet (VLCKD) has shown to significantly reduce body weight and fat mass, as well as inflammation. These effects are supported by nutritional ketosis, which triggers the utilization o...

    Authors: Claudia Vetrani, Ludovica Verde, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri and Luigi Barrea
    Citation: Journal of Translational Medicine 2023 21:29
    Content type: Research Published on:

  23. Nonobese metabolic dysfunction-associated fatty liver disease (MAFLD) is paradoxically associated with improved metabolic and pathological features at diagnosis but similar cardiovascular diseases (CVD) progno...

    Authors: Congxiang Shao, Lishu Xu, Pingguang Lei, Wei Wang, Shiting Feng, Junzhao Ye and Bihui Zhong
    Citation: Journal of Translational Medicine 2023 21:12
    Content type: Research Published on:

  24. Astronauts undergo significant microgravity-induced bone loss during space missions, which has become one of the three major medical problems hindering human's long-term space flight. A risk-free and antiresor...

    Authors: Ranli Gu, Hao Liu, Menglong Hu, Yuan Zhu, Xuenan Liu, Feilong Wang, Likun Wu, Danyang Song and Yunsong Liu
    Citation: Journal of Translational Medicine 2023 21:8
    Content type: Research Published on:

  25. Nonalcoholic fatty liver disease (NAFLD) is closely associated with Cardiovascular disease (CVD). We aim to examine the association of Life’s Essential 8 (LE8), the recently updated measurement of cardiovascul...

    Authors: Lili Wang, Jiayi Yi, Xinli Guo and Xiangpeng Ren
    Citation: Journal of Translational Medicine 2022 20:616
    Content type: Research Published on:

  26. Type 2 diabetes (T2D) onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. This study aims to find out the key drivers an...

    Authors: Jiachen Liu, Shenghua Liu, Zhaomei Yu, Xiaorui Qiu, Rundong Jiang and Weizheng Li
    Citation: Journal of Translational Medicine 2022 20:604
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:207

  27. Renal anemia is caused by end-stage renal disease (ESRD) but has a complex etiology. The application of dietary fiber (DF) to regulate the gut microbiota has shown effective therapeutic effects in some disease...

    Authors: Yang Li, Min Han, Jia Song, Shijin Liu, Yongjun Wang, Xinhuan Su, Kai Wei, Zhen Xu, Hui Li and Zunsong Wang
    Citation: Journal of Translational Medicine 2022 20:599
    Content type: Research Published on:

  28. Microbiota and its metabolites are known to regulate host metabolism. In cross-sectional study conducted in postmenopausal women we aimed to assess whether the microbiota, its metabolites and gut barrier integ...

    Authors: Igor Łoniewski, Monika Szulińska, Mariusz Kaczmarczyk, Konrad Podsiadło, Daniel Styburski, Karolina Skonieczna-Żydecka and Paweł Bogdański
    Citation: Journal of Translational Medicine 2022 20:585
    Content type: Research Published on:

  29. Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder with abnormal lipid metabolism. The present study was to identify regulatory genes related to lipid droplets (LDs) abnormal accumulation in NAFLD.

    Authors: Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan and Jiequn Li
    Citation: Journal of Translational Medicine 2022 20:529
    Content type: Research Published on:

  30. Identifying patterns of variation in obesity indices and other cardiometabolic risk factors before the diagnosis of type 2 diabetes could provide insight into the critical period when drastic changes occurred ...

    Authors: Fatemeh Koohi, Nooshin Ahmadi, Fereidoun Azizi, Davood Khalili and Majid Valizadeh
    Citation: Journal of Translational Medicine 2022 20:518
    Content type: Research Published on:

  31. Diabetic kidney disease (DKD) is among the most important causes for chronic kidney disease. Anthocyanins (ANT) are polyphenolic compounds present in various food and play an important role in ameliorating hyp...

    Authors: Yi-Xi Li, Yong-Ping Lu, Donge Tang, Bo Hu, Ze-Yu Zhang, Hong-Wei Wu, Li-Jing Fan, Kai-Wen Cai, Chun Tang, Yi-Qing Zhang, Ling Hong, Jing-jing Dong, Bao-zhang Guan, Liang-Hong Yin, Yong Dai, Wei-bin Bai…
    Citation: Journal of Translational Medicine 2022 20:510
    Content type: Research Published on:

  32. Apparent mineralocorticoid excess is an autosomal recessive form of monogenic disease characterized by juvenile resistant low-renin hypertension, marked hypokalemic alkalosis, low aldosterone levels, and high ...

    Authors: Yi-ting Lu, Di Zhang, Qiong-yu Zhang, Ze-ming Zhou, Kun-qi Yang, Xian-liang Zhou and Fan Peng
    Citation: Journal of Translational Medicine 2022 20:500
    Content type: Review Published on:

  33. This paper aimed to examine the effects of probiotics on eight factors in the prediabetic population by meta-analysis, namely, fasting blood glucose (FBG), glycated haemoglobin A1c (HbA1c), homeostatic model a...

    Authors: Ya Li, You Wu, Lili Wu, Lingling Qin and Tonghua Liu
    Citation: Journal of Translational Medicine 2022 20:498
    Content type: Review Published on:

  34. To explore the roles of Annexin A2 (ANXA2) on hepatocyte pyroptosis and hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and underlying molecular mechanism.

    Authors: Yun Feng, Wenhua Li, Zhuoya Wang, Ruling Zhang, Yan Li, Lijuan Zang, Peiwen Wang, Zhenghong Li and Yuwei Dong
    Citation: Journal of Translational Medicine 2022 20:497
    Content type: Research Published on:

  35. Obesity (waist circumference, body mass index (BMI)) and lifestyle factors (dietary habits, smoking, alcohol drinking, Sedentary behavior) have been associated with risk of benign prostatic hyperplasia (BPH) i...

    Authors: Yong-Bo Wang, Lan Yang, Yu-Qing Deng, Si-Yu Yan, Li-Sha Luo, Ping Chen and Xian-Tao Zeng
    Citation: Journal of Translational Medicine 2022 20:495
    Content type: Research Published on:

  36. Osteoporosis (OP) is a systemic bone disease characterized by the decreased bone mass and destruction of bone microstructure, which tends to result in the enhanced bone fragility and related fractures, as well...

    Authors: Yuan-Wei Zhang, Mu-Min Cao, Ying-Juan Li, Xiang-Xu Chen, Qian Yu and Yun-Feng Rui
    Citation: Journal of Translational Medicine 2022 20:490
    Content type: Review Published on:

  37. Evidence about the relationship between triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and prediabetes (Pre-DM) in Chinese non-obese people with a normal range of low-density lipoprotein...

    Authors: Liling Wu, Xiaodan Wu, Haofei Hu and Qijun Wan
    Citation: Journal of Translational Medicine 2022 20:484
    Content type: Research Published on:

  38. Proteinuria is an unfavorable clinical condition highly associated with a risk of renal and cardiovascular disease in chronic kidney disease (CKD). However, whether all proteinuria forms are linked to renal im...

    Authors: Chun Gan, Xindi Zhou, Dan Chen, Huan Chi, Jiawen Qiu, Hui You, Yaxi Chen, Mo Wang, Haiping Yang, Wei Jiang and Qiu Li
    Citation: Journal of Translational Medicine 2022 20:480
    Content type: Research Published on:

  39. The combined association of triglyceride-glucose (TyG) index and different systolic blood pressure (SBP) levels with all-cause and cardiovascular mortality among the general population remains unclear.

    Authors: Yu Yu, Min Gu, Hao Huang, Sijing Cheng, Yu Deng, Chi Cai, Xuhua Chen, Hongxia Niu, Xiaohui Ning and Wei Hua
    Citation: Journal of Translational Medicine 2022 20:478
    Content type: Research Published on:

  40. Nutritional assessment and quality of life (QOL) have become important indices for therapeutic efficacy in patients with malignancies. We aim to develop and validate an easy-to-use questionnaire with prognosti...

    Authors: Bingdong Zhang, Yuerui Li and Yongbing Chen
    Citation: Journal of Translational Medicine 2022 20:477
    Content type: Research Published on:

  41. Trimethylamine oxide (TMAO) is a biomarker in cardiovascular and renal diseases. TMAO originates from the oxidation of trimethylamine (TMA), a product of gut microbiota and manufacturing industries-derived pol...

    Authors: Klaudia M. Maksymiuk, Mateusz Szudzik, Marta Gawryś-Kopczyńska, Maksymilian Onyszkiewicz, Emilia Samborowska, Izabella Mogilnicka and Marcin Ufnal
    Citation: Journal of Translational Medicine 2022 20:470
    Content type: Research Published on:

  42. Probiotics have been defined as “living microorganisms that create health benefits in the host when taken in sufficient amounts. Recent developments in the understanding of the relationship between the microbi...

    Authors: Duygu Ağagündüz, Feray Gençer Bingöl, Elif Çelik, Özge Cemali, Çiler Özenir, Fatih Özoğul and Raffaele Capasso
    Citation: Journal of Translational Medicine 2022 20:460
    Content type: Review Published on:

  43. C1q/tumor necrosis factor-related protein 1 (CTRP1) is an adipokine secreted by adipose tissue, related to chondrocyte proliferation, inflammation, and glucose homeostasis. However, the therapeutic effects on ...

    Authors: Mingzhi Ren, Jianfei Pan, Xueying Yu, Kaile Chang, Xiaopeng Yuan and Chunbo Zhang
    Citation: Journal of Translational Medicine 2022 20:449
    Content type: Research Published on:

  44. Akkermansia muciniphila (A. muciniphila) is present in the human gut microbiota from infancy and gradually increases in adulthood. The potential impact of the abundance of A. muciniphila has been studied in major...

    Authors: Arun Prasath Lakshmanan, Selvasankar Murugesan, Souhaila Al Khodor and Annalisa Terranegra
    Citation: Journal of Translational Medicine 2022 20:430
    Content type: Review Published on:

  45. Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. SGLT2 inhibitors are clinically effective in halting DKD progression. However, the underlying mechanisms remain u...

    Authors: Yong-Ping Lu, Ze-Yu Zhang, Hong-Wei Wu, Li-Jing Fang, Bo Hu, Chun Tang, Yi-Qing Zhang, Lianghong Yin, Dong-E. Tang, Zhi-Hua Zheng, Ting Zhu and Yong Dai
    Citation: Journal of Translational Medicine 2022 20:420
    Content type: Research Published on:

  46. The association between body mass index (BMI) and Alzheimer's disease (AD) remains controversial. Genetic and environmental factors are now considered contributors to AD risk. However, little is known about th...

    Authors: Shiqi Yuan, Wentao Wu, Wen Ma, Xiaxuan Huang, Tao Huang, MIn Peng, Anding Xu and Jun Lyu
    Citation: Journal of Translational Medicine 2022 20:417
    Content type: Research Published on:

  47. Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma Coptis, is widely used in the treatment of hyperlipidemia (HLP) in China. At present, the efficacy of BBR against HLP is relatively clear, but th...

    Authors: Yuting Chen, Kaipeng Li, Han Zhao, Zhangsen Hao, Yuxin Yang, Mingming Gao and Ding Zhao
    Citation: Journal of Translational Medicine 2022 20:412
    Content type: Research Published on:

  48. Omega-3 may alleviate the severity of coronavirus disease 2019 (COVID-19) by reducing the C-reactive protein (CRP) level, a marker for systemic inflammation. Because the scientific evidence indicating such a r...

    Authors: Amira Mohamed Taha, Ahmad Shehata Shaarawy, Mohamed Mosad Omar, Khaled Abouelmagd, Noran Magdy Shalma, Mais Alhashemi, Hala Mahmoud Ahmed, Ahmed Hafez Allam and Mohamed Abd-ElGawad
    Citation: Journal of Translational Medicine 2022 20:401
    Content type: Review Published on:

  49. An imbalance in the expression of vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) during pregnancy plays an important role in the pathogenesis of gestational diabetes mellitus (GDM) and ecl...

    Authors: Alayi Bolatai, Yujing He and Na Wu
    Citation: Journal of Translational Medicine 2022 20:400
    Content type: Review Published on:

  50. By identifying individuals at high risk for non-alcoholic fatty liver disease (NAFLD), interventional programs could be targeted more effectively. Some studies have demonstrated that triglyceride glucose-body ...

    Authors: Haofei Hu, Yong Han, Changchun Cao and Yongcheng He
    Citation: Journal of Translational Medicine 2022 20:398
    Content type: Research Published on:
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