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Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. The risk of cardiovascular diseases (CVD) is increased tremendously among menopausal women, and there is an increasing demand for alternative therapies for managing factors like dyslipidemia that contribute to...

    Authors: Ramlah Mohamad Ibrahim, Nurul Syima Hamdan, Rozi Mahmud, Mustapha Umar Imam, Suraini Mohd Saini, Saiful Nizam Abd Rashid, Siti Aisyah Abd Ghafar, Latiffah Ab Latiff and Maznah Ismail

    Citation: Journal of Translational Medicine 2014 12:82

    Content type: Research

    Published on:

  2. It has been argued that circadian dysregulation is not only a critical inducer and promoter of adverse health effects, exacerbating symptom burden, but also hampers recovery. Therefore understanding the health...

    Authors: Jag Sunderram, Stavroula Sofou, Kubra Kamisoglu, Vassiliki Karantza and Ioannis P Androulakis

    Citation: Journal of Translational Medicine 2014 12:79

    Content type: Review

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  3. To describe the preparation of nano emodin transfersome (NET) and investigate its effect on mRNA expression of adipose triglyceride lipase (ATGL) and G0/G1 switch gene 2 (G0S2) in adipose tissue of diet-induce...

    Authors: Kun Lu, Shuanshuan Xie, Shilong Han, Jidong Zhang, Xinwen Chang, Jin Chao, Qingqing Huang, Qing Yuan, Haiyan Lin, Lei Xu, Changxing Shen, Min Tan, Shen Qu, Changhui Wang and Xiaolian Song

    Citation: Journal of Translational Medicine 2014 12:72

    Content type: Research

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  4. Nuclear factor erythroid-2-related factor-2 (Nrf2) is known to protect against tissue injury by orchestrating antioxidant and detoxification responses to oxidative stress. This study investigated whether upreg...

    Authors: Yu Ah Hong, Ji Hee Lim, Min Young Kim, Eun Nim Kim, Eun Sil Koh, Seok Joon Shin, Bum Soon Choi, Cheol Whee Park, Yoon Sik Chang and Sungjin Chung

    Citation: Journal of Translational Medicine 2014 12:50

    Content type: Research

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  5. Insulin resistance plays an important role in the development of metabolic syndrome (MS). Fu Fang Zhen Zhu Tiao Zhi formula (FTZ), a Chinese medicinal decoction, has been used to relieve hyperlipidemia, athero...

    Authors: Xuguang Hu, Man Wang, Weijian Bei, Zongyu Han and Jiao Guo

    Citation: Journal of Translational Medicine 2014 12:47

    Content type: Research

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  6. A positive association between handgrip strength and bone mineral density was demonstrated, but not all the investigations confirmed these results. We conducted a screening programme for osteoporosis in a larg...

    Authors: Theodora Lamprinoudi, Elisa Mazza, Yvelise Ferro, Simona Brogneri, Daniela Foti, Elio Gulletta, Maurizio Iocco, Carmine Gazzaruso, Stefano Romeo, Arturo Pujia and Tiziana Montalcini

    Citation: Journal of Translational Medicine 2014 12:46

    Content type: Research

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  7. Body image perception depends on anthropometric and psychological factors. Body dissatisfaction is influenced by the socio-cultural environment and is associated with eating disorders and low self-esteem. This...

    Authors: Luciana Zaccagni, Sabrina Masotti, Roberta Donati, Gianni Mazzoni and Emanuela Gualdi-Russo

    Citation: Journal of Translational Medicine 2014 12:42

    Content type: Research

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  8. Nephrolithiasis is more frequent and severe in obese patients from different western nations. This may be supported by higher calcium, urate, oxalate excretion in obese stone formers. Except these parameters, ...

    Authors: Laura Soldati, Simona Bertoli, Annalisa Terranegra, Caterina Brasacchio, Alessandra Mingione, Elena Dogliotti, Benedetta Raspini, Alessandro Leone, Francesca Frau, Laila Vignati, Angela Spadafranca, Giuseppe Vezzoli, Daniele Cusi and Alberto Battezzati

    Citation: Journal of Translational Medicine 2014 12:34

    Content type: Research

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  9. Little is known about the involvement of matrix metalloproteinases (MMPs) in cardiac vascular remodelling induced by exercise. Our aim was to evaluate and localize MMP-2 and MMP-9’s activities in relation to c...

    Authors: Marianna Bellafiore, Giuseppe Battaglia, Antonino Bianco, Felicia Farina, Antonio Palma and Antonio Paoli

    Citation: Journal of Translational Medicine 2013 11:283

    Content type: Research

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  10. Bone is one of the major target tissues for Insulin-like Growth Factor I (IGF-I). Low doses of IGF-I were able to improve liver-associated osteopenia. In the present work, a model of partial IGF-I deficiency w...

    Authors: Lucia Guerra-Menéndez, Maria C Sádaba, Juan E Puche, Jose L Lavandera, Luis F de Castro, Arancha R de Gortázar and Inma Castilla-Cortázar

    Citation: Journal of Translational Medicine 2013 11:271

    Content type: Research

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  11. The role of body composition (lean mass and fat mass) on urine chemistries and bone quality is still debated. Our aim was therefore to determine the effect of lean mass and fat mass on urine composition and bo...

    Authors: Antonio Nouvenne, Andrea Ticinesi, Angela Guerra, Giuseppina Folesani, Franca Allegri, Silvana Pinelli, Paolo Baroni, Mario Pedrazzoni, Giuseppe Lippi, Annalisa Terranegra, Elena Dogliotti, Laura Soldati, Loris Borghi and Tiziana Meschi

    Citation: Journal of Translational Medicine 2013 11:248

    Content type: Research

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  12. The prevalence of vitamin D deficiency among patients with cancer has been previously reported. Because vitamin D is fat soluble, patients with pancreatic adenocarcinoma may have an especially high risk of vit...

    Authors: May Cho, Parvin F Peddi, Kevin Ding, Ling Chen, Denise Thomas, Jian Wang, Albert C Lockhart, Benjamin Tan and Andrea Wang-Gillam

    Citation: Journal of Translational Medicine 2013 11:206

    Content type: Research

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  13. High systemic estrogen levels contribute to breast cancer risk for postmenopausal women, whereas low levels contribute to osteoporosis risk. Except for obesity, determinants of non-ovarian systemic estrogen le...

    Authors: Roberto Flores, Jianxin Shi, Barbara Fuhrman, Xia Xu, Timothy D Veenstra, Mitchell H Gail, Pawel Gajer, Jacques Ravel and James J Goedert

    Citation: Journal of Translational Medicine 2012 10:253

    Content type: Research

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  14. Protein dynamics during non-steady state conditions as feeding are complex. Such studies usually demand combinations of methods to give conclusive information, particularly on myofibrillar proteins with slow t...

    Authors: Britt-Marie Iresjö and Kent Lundholm

    Citation: Journal of Translational Medicine 2012 10:238

    Content type: Research

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  15. Advanced studies of microRNAs (miRNAs) have revealed their manifold biological functions, including control of cell proliferation, cell cycle and cell death. However, it seems that their roles as key regulator...

    Authors: Bing Chen, Hongbin Li, Xiao Zeng, Pengbo Yang, Xinyu Liu, Xia Zhao and Shufang Liang

    Citation: Journal of Translational Medicine 2012 10:228

    Content type: Review

    Published on:

  16. Epithelial-mesenchymal transition of tubular cells is a widely recognized mechanism that sustains interstitial fibrosis in diabetic nephropathy (DN). The signaling of FGF-2, a growth factor involved in this me...

    Authors: Valentina Masola, Maurizio Onisto, Gianluigi Zaza, Antonio Lupo and Giovanni Gambaro

    Citation: Journal of Translational Medicine 2012 10:213

    Content type: Research

    Published on:

  17. Nonylphenol (NP), an environmental organic compound, has been demonstrated to enhance reactive-oxygen species (ROS) synthesis. Chronic exposure to low-dose adenine (AD) has been reported to induce chronic kidn...

    Authors: Chia-Hung Yen, Cheuk-Kwan Sun, Steve Leu, Christopher Glenn Wallace, Yu-Chun Lin, Li-Teh Chang, Yung-Lung Chen, Tzu-Hsien Tsa, Ying-Hsien Kao, Pei-Lin Shao, Chi-Ying Hsieh, Yen-Ta Chen and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2012 10:147

    Content type: Research

    Published on:

  18. Obesity is an important cardiovascular risk factor. This study tested the effect of obesity reduction on preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and ...

    Authors: Hui-Ting Wang, Chu-Feng Liu, Tzu-Hsien Tsai, Yung-Lung Chen, Hsueh-Wen Chang, Ching-Yen Tsai, Steve Leu, Yen-Yi Zhen, Han-Tan Chai, Sheng-Ying Chung, Sarah Chua, Chia-Hung Yen and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2012 10:145

    Content type: Research

    Published on:

  19. Low birth weight has been linked to an increased risk to develop obesity, type 2 diabetes, and hypertension in adult life, although the mechanisms underlying the association are not well understood. The object...

    Authors: Carmen Ivorra, Consuelo García-Vicent, Felipe Javier Chaves, Daniel Monleón, José Manuel Morales and Empar Lurbe

    Citation: Journal of Translational Medicine 2012 10:142

    Content type: Research

    Published on:

  20. This study tested the hypothesis that obesity suppresses circulating number as well as the function of endothelial progenitor cells (EPCs) and left ventricular ejection fraction (LVEF).

    Authors: Tzu-Hsien Tsai, Han-Tan Chai, Cheuk-Kwan Sun, Chia-Hung Yen, Steve Leu, Yung-Lung Chen, Sheng-Ying Chung, Sheung-Fat Ko, Hsueh-Wen Chang, Chiung-Jen Wu and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2012 10:137

    Content type: Research

    Published on:

  21. Experimental studies suggested that high serum calcium may be important in the pathogenesis of vascular diseases. Since calcium seems to affect specifically the cerebrovascular district, aim of this study was ...

    Authors: Tiziana Montalcini, Gaetano Gorgone and Arturo Pujia

    Citation: Journal of Translational Medicine 2012 10:114

    Content type: Research

    Published on:

  22. Nutrition has been widely recognized to influence the risk of kidney stone formation. Therefore the aim of our study was to assess: a) whether usual diet of women with idiopathic calcium nephrolithiasis (ICN) ...

    Authors: Tiziana Meschi, Antonio Nouvenne, Andrea Ticinesi, Beatrice Prati, Angela Guerra, Franca Allegri, Federica Pigna, Laura Soldati, Giuseppe Vezzoli, Giovanni Gambaro, Fulvio Lauretani, Marcello Maggio and Loris Borghi

    Citation: Journal of Translational Medicine 2012 10:63

    Content type: Research

    Published on:

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