Section edited by Luis F. Alguacil

The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field.

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  1. Research

    Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial

    Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. Kv7 channels are expressed along myelinated and unmyelinated peripheral axons where their activation is expecte...

    Johannes Fleckenstein, Ruth Sittl, Beate Averbeck, Philip M Lang, Dominik Irnich and Richard W Carr

    Journal of Translational Medicine 2013 11:34

    Published on: 8 February 2013

  2. Review

    Nerve growth factor: from the early discoveries to the potential clinical use

    The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocr...

    Luigi Aloe, Maria Luisa Rocco, Patrizia Bianchi and Luigi Manni

    Journal of Translational Medicine 2012 10:239

    Published on: 29 November 2012

  3. Research

    Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation

    Alzheimer’s Disease (AD) is the most widespread form of dementia in the elderly but despite progress made in recent years towards a mechanistic understanding, there is still an urgent need for disease modifica...

    Ines Greco, Nicola Day, Joanna Riddoch-Contreras, Jane Reed, Hilkka Soininen, Iwona Kłoszewska, Magda Tsolaki, Bruno Vellas, Christian Spenger, Patrizia Mecocci, Lars-Olof Wahlund, Andrew Simmons, Julie Barnes and Simon Lovestone

    Journal of Translational Medicine 2012 10:217

    Published on: 31 October 2012

  4. Research

    MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR

    Methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter is a favorable prognostic factor in glioblastoma patients. However, reported methylation frequencies vary significantly partly due to...

    Annette Bentsen Håvik, Petter Brandal, Hilde Honne, Hanne-Sofie Spenning Dahlback, David Scheie, Merete Hektoen, Torstein Ragnar Meling, Eirik Helseth, Sverre Heim, Ragnhild A Lothe and Guro Elisabeth Lind

    Journal of Translational Medicine 2012 10:36

    Published on: 6 March 2012

  5. Research

    Identification and proteomic profiling of exosomes in human cerebrospinal fluid

    Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker discovery. They can transfer information between cells and ma...

    Jonathan M Street, Perdita E Barran, C Logan Mackay, Stefan Weidt, Craig Balmforth, Tim S Walsh, Rod TA Chalmers, David J Webb and James W Dear

    Journal of Translational Medicine 2012 10:5

    Published on: 5 January 2012

  6. Research

    MicroRNA modulation in complex regional pain syndrome

    Aberrant expression of small noncoding RNAs called microRNAs (miRNAs) is a common feature of several human diseases. The objective of the study was to identify miRNA modulation in patients with complex regiona...

    Irina A Orlova, Guillermo M Alexander, Rehman A Qureshi, Ahmet Sacan, Alessandro Graziano, James E Barrett, Robert J Schwartzman and Seena K Ajit

    Journal of Translational Medicine 2011 9:195

    Published on: 10 November 2011

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