Skip to main content

Neuroscience

Section edited by Maria Jose Polanco Mora

The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field. Any new tool for the dissemination of results in the field can greatly help to progress in the new solutions for the neuropsychiatric patient. The section aims to promote the increase of knowledge on the subject by publishing original research. 

Page 2 of 3

  1. The intrathecal (IT) dosing route introduces drugs directly into the CSF to bypass the blood–brain barrier and gain direct access to the CNS. We evaluated the use of convective forces acting on the cerebrospin...

    Authors: Jenna M. Sullivan, Curt Mazur, Daniel A. Wolf, Laura Horky, Nicolas Currier, Bethany Fitzsimmons, Jacob Hesterman, Rachel Pauplis, Scott Haller, Berit Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly Kordasiewicz, Eric E. Swayze and Ajay Verma
    Citation: Journal of Translational Medicine 2020 18:309
  2. Ischemic stroke (IS) is the second leading cause of death worldwide which is a serious hazard to human health. Evidence suggests that the immune system plays a key role in the pathophysiology of IS. However, t...

    Authors: Zijian Li, Yueran Cui, Juan Feng and Yanxia Guo
    Citation: Journal of Translational Medicine 2020 18:296
  3. Brain aging is a major risk factor in the progression of cognitive diseases including Alzheimer’s disease (AD) and vascular dementia. We investigated a mouse model of brain aging up to 24 months old (mo).

    Authors: Erik N. Taylor, Nasi Huang, Jonathan Wisco, Yandan Wang, Kathleen G. Morgan and James A. Hamilton
    Citation: Journal of Translational Medicine 2020 18:277
  4. 17AAG has been extensively studied for its antitumor effects that protect cells from lethal stress by maintaining protein stability. The role of 17AAG in sevoflurane-induced neuronal injury has never been stud...

    Authors: Min Liu, Moyun Li, Yu Zhou, Qian Zhou and Yugang Jiang
    Citation: Journal of Translational Medicine 2020 18:166
  5. Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal dege...

    Authors: Magda M. Santana, Susana Paixão, Janete Cunha-Santos, Teresa Pereira Silva, Allyson Trevino-Garcia, Laetitia S. Gaspar, Clévio Nóbrega, Rui Jorge Nobre, Cláudia Cavadas, Hagar Greif and Luís Pereira de Almeida
    Citation: Journal of Translational Medicine 2020 18:161
  6. Peroxiredoxin activated in M-CSF stimulated monocytes (PAMM) is a novel protein produced by adipocytes with putative redox regulatory and anti-inflammatory properties. Because acute spinal cord injury (SCI) is...

    Authors: Leslie R. Morse, Nguyen Nguyen, Yan Xu, Prakash Jha and Ricardo A. Battaglino
    Citation: Journal of Translational Medicine 2020 18:135
  7. Inflammatory damage following stroke aggravates brain damage, resulting in long-term neurological sequelae. The purpose of this study was to identify ways to reduce inflammatory reactions and to accelerate neu...

    Authors: Benping Zhang, Qian Li, Shuwei Jia, Feng Li, Qingsong Li and Jiebing Li
    Citation: Journal of Translational Medicine 2020 18:110
  8. Myelin sheaths surrounding axons are critical for electrical signal transmission in the central nervous system (CNS). Diseases with myelin defects such as multiple sclerosis (MS) are devastating neurological c...

    Authors: Sujun Ding, Yun Gu, Yunyun Cai, Meijuan Cai, Tuo Yang, Shuangxi Bao, Weixing Shen, Xuejun Ni, Gang Chen and Lingyan Xing
    Citation: Journal of Translational Medicine 2020 18:109
  9. Parkinson’s disease (PD) is a neurodegenerative disorder that results in the death of dopaminergic neurons within the substantia nigra pars compacta and the reduction in dopaminergic control over striatal output ...

    Authors: Inma Castilla-Cortázar, Gabriel A. Aguirre, Giovana Femat-Roldán, Irene Martín-Estal and Luis Espinosa
    Citation: Journal of Translational Medicine 2020 18:70
  10. Gap junctions are involved in the development of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH). However, the specific roles and regulatory functions of related connexin isoforms remain unknown. ...

    Authors: Le Yang, Jian Yan, Jin-An Zhang, Xin-Hui Zhou, Chao Fang, Er-Ming Zeng, Bin Tang, Jian Duan, Guo-Hui Lu and Tao Hong
    Citation: Journal of Translational Medicine 2019 17:433
  11. Xenon (Xe) is a noble gas that has been used for the last several decades as an anesthetic during surgery. Its antagonistic effect on glutamate subtype of NMDA (N-methyl-d-aspartate) receptors resulted in evaluat...

    Authors: A. P. Dobrovolsky, V. R. Gedzun, V. I. Bogin, D. Ma, T. E. Ichim, Iu. A. Sukhanova, A. V. Malyshev and V. A. Dubynin
    Citation: Journal of Translational Medicine 2019 17:400
  12. Developmental processes in the placenta and the fetal brain are shaped by the similar biological signals. Evidence accumulates that adaptive responses of the placenta may influence central nervous system devel...

    Authors: Esmée M. Bijnens, Catherine Derom, Steven Weyers, Bram G. Janssen, Evert Thiery and Tim S. Nawrot
    Citation: Journal of Translational Medicine 2019 17:361
  13. Biallelic PTPRQ pathogenic variants have been previously reported as causative for autosomal recessive non-syndromic hearing loss. In 2018 the first heterozygous PTPRQ variant has been implicated in the developme...

    Authors: Dominika Oziębło, Anna Sarosiak, Marcin L. Leja, Birgit S. Budde, Grażyna Tacikowska, Nataliya Di Donato, Hanno J. Bolz, Peter Nürnberg, Henryk Skarżyński and Monika Ołdak
    Citation: Journal of Translational Medicine 2019 17:351
  14. It has been established that children with Autism Spectrum Disorders (ASD) are affected by oxidative stress, the origin of which is still under investigation. In the present work, we evaluated inflammatory and...

    Authors: P. M. Abruzzo, A. Matté, A. Bolotta, E. Federti, A. Ghezzo, T. Guarnieri, M. Marini, A. Posar, A. Siciliano, L. De Franceschi and P. Visconti
    Citation: Journal of Translational Medicine 2019 17:332
  15. Hearing loss (HL) is the most common disability of human senses characterized by a great allelic heterogeneity. GJB2 and TMPRSS3 are two well-known HL genes typically underlying its monogenic form. Recently, TMPR...

    Authors: Monika Ołdak, Urszula Lechowicz, Agnieszka Pollak, Dominika Oziębło and Henryk Skarżyński
    Citation: Journal of Translational Medicine 2019 17:269
  16. The adipose afferent reflex (AAR), a sympatho-excitatory reflex, can promote the elevation of sympathetic nerve activity (SNA) and blood pressure (BP). Inflammation in the paraventricular nucleus (PVN) involve...

    Authors: Lei Ding, Ying Kang, Hang-Bing Dai, Fang-Zheng Wang, Hong Zhou, Qing Gao, Xiao-Qing Xiong, Feng Zhang, Tian-Run Song, Yan Yuan, Ming Liu, Guo-Qing Zhu and Ye-Bo Zhou
    Citation: Journal of Translational Medicine 2019 17:256
  17. Acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is a devastating cerebrovascular disorder, which could benefit from collateral circulation. Proteins associated with acute LVO pathogenesis and e...

    Authors: Chuan Qin, Xin-Ling Zhao, Xiao-Tong Ma, Luo-Qi Zhou, Long-jun Wu, Ke Shang, Wei Wang and Dai-Shi Tian
    Citation: Journal of Translational Medicine 2019 17:214
  18. Flow diverter devices are increasingly used for endovascular treatment of internal carotid artery aneurysms. Treatment of ophthalmic segment aneurysms with flow diverter devices also includes coverage of the o...

    Authors: Xinzhi Wu, Zhongbin Tian, Jian Liu, Wenqiang Li, Junfan Chen, Yangyang Zhou, Xinjian Yang and Shiqing Mu
    Citation: Journal of Translational Medicine 2019 17:160
  19. Changes in brain metabolism has been investigated thoroughly during unilateral cervical chronic vagal stimulation in epileptic or depressive patients. Bilateral stimulation of the abdominal vagus (aVNS) has recei...

    Authors: Charles-Henri Malbert, Mickael Genissel, Jean-Louis Divoux and Christine Henry
    Citation: Journal of Translational Medicine 2019 17:78
  20. There are no guidelines concerning the best approach to improving sleep, but it has been shown that it can benefit the affected children and their entire families. The aim of this review is to analyse the effi...

    Authors: Susanna Esposito, Daniela Laino, Renato D’Alonzo, Annalisa Mencarelli, Lorenza Di Genova, Antonella Fattorusso, Alberto Argentiero and Elisabetta Mencaroni
    Citation: Journal of Translational Medicine 2019 17:77
  21. Glioblastoma multiform (GBM) is a devastating brain tumor with maximum surgical resection, radiotherapy plus concomitant and adjuvant temozolomide (TMZ) as the standard treatment. Diverse clinicopathological a...

    Authors: Wei-Zhen Gao, Lie-Mei Guo, Tian-Qi Xu, Yu-Hua Yin and Feng Jia
    Citation: Journal of Translational Medicine 2018 16:368
  22. Neurogenic bowel dysfunction (NBD) is a major physical and psychological problem in patients with spinal cord injury (SCI), and gut dysbiosis is commonly occurs in SCI. Here, we document neurogenic bowel manag...

    Authors: Chao Zhang, Wenhao Zhang, Jie Zhang, Yingli Jing, Mingliang Yang, Liangjie Du, Feng Gao, Huiming Gong, Liang Chen, Jun Li, Hongwei Liu, Chuan Qin, Yanmei Jia, Jiali Qiao, Bo Wei, Yan Yu…
    Citation: Journal of Translational Medicine 2018 16:353
  23. Acute ischemic stroke is a leading cause of mortality and long-term disability, and profiles of endothelial progenitor cells (EPCs) reflect the degree of endothelial impairment. This study tested the hypothesi...

    Authors: Chen-Yu Chen, Re-Wen Wu, Nai-Wen Tsai, Mel S. Lee, Wei-Che Lin, Mei-Chi Hsu, Chih-Cheng Huang, Yun-Ru Lai, Chia-Te Kung, Hung-Chen Wang, Yu-Jih Su, Chih-Min Su, Sheng-Yuan Hsiao, Ben-Chung Cheng, Yi-Fang Chiang and Cheng-Hsien Lu
    Citation: Journal of Translational Medicine 2018 16:255
  24. Fatigue is a common problem among individuals with Parkinson’s disease (PD). It may occur before the overt symptoms of bradykinesia, rigidity and tremor. Little is understood about how to measure fatigue in PD...

    Authors: Raymond Chong, Lauren Albor, Chandramohan Wakade and John Morgan
    Citation: Journal of Translational Medicine 2018 16:192
  25. For nearly four decades, the N400 has been an important brainwave marker of semantic processing. It can be recorded non-invasively from the scalp using electrical and/or magnetic sensors, but largely within th...

    Authors: Sujoy Ghosh Hajra, Careesa C. Liu, Xiaowei Song, Shaun D. Fickling, Teresa P. L. Cheung and Ryan C. N. D’Arcy
    Citation: Journal of Translational Medicine 2018 16:151
  26. Mental illness contributes substantially to global disease burden, particularly when illness onset occurs during youth and help-seeking is delayed and/or limited. Yet, few mental health promotion interventions...

    Authors: Joanna Yang, Roberto Lopez Cervera, Susannah J. Tye, Stephen C. Ekker and Chris Pierret
    Citation: Journal of Translational Medicine 2018 16:84
  27. Magnetic stimulation of the facial nerve has been tested in preclinical studies as a new, non-invasive emergency treatment of ischemic stroke that acts by increasing cerebral blood flow (CBF). The objective of...

    Authors: Olivia Sanchez, Andrea García, Fernando Castro-Prado, Miriam Perez, Rafael Lara-Estrada, Martin Ramirez-Meza, Montserrat Godinez, Michael L. Coco, Joaquín Azpiroz, Mark K. Borsody and Emilio Sacristán
    Citation: Journal of Translational Medicine 2018 16:27
  28. Hearing loss and ovarian dysfunction are key features of Perrault syndrome (PRLTS) but the clinical and pathophysiological features of hearing impairment in PRLTS individuals have not been addressed. Mutations...

    Authors: Monika Ołdak, Dominika Oziębło, Agnieszka Pollak, Iwona Stępniak, Michal Lazniewski, Urszula Lechowicz, Krzysztof Kochanek, Mariusz Furmanek, Grażyna Tacikowska, Dariusz Plewczynski, Tomasz Wolak, Rafał Płoski and Henryk Skarżyński
    Citation: Journal of Translational Medicine 2017 15:25
  29. Studies have indicated that bone marrow stromal cell (BMSC) administration is a promising approach for stroke treatment. For our study, we chose sodium ferulate (SF) and n-butylidenephthalide (BP) combined with B...

    Authors: Qian Zhang, Yonghua Zhao, Youhua Xu, Zhenwei Chen, Naiwei Liu, Chienchih Ke, Bowen Liu and Weikang Wu
    Citation: Journal of Translational Medicine 2016 14:223
  30. Systemic inflammation, neurocognitive impairments, and morphologic brain changes are associated with obstructive sleep apnea (OSA). Understanding their longitudinal evolution and interactions after surgical tr...

    Authors: Wei-Che Lin, Chih-Cheng Huang, Hsiu-Ling Chen, Kun-Hsien Chou, Pei-Chin Chen, Nai-Wen Tsai, Meng-Hsiang Chen, Michael Friedman, Hsin-Ching Lin and Cheng-Hsien Lu
    Citation: Journal of Translational Medicine 2016 14:139
  31. Vagus nerve stimulation (VNS) has become the most common non-pharmacological treatment for intractable drug-resistant epilepsy. However, the contribution of VNS to neurological rehabilitation following stroke ...

    Authors: Ai-fen Liu, Feng-bo Zhao, Jing Wang, Yi-Fan Lu, Jian Tian, Yin Zhao, Yan Gao, Xia-jun Hu, Xiao-yan Liu, Jie Tan, Yun-li Tian and Jing Shi
    Citation: Journal of Translational Medicine 2016 14:101
  32. It is generally acknowledged that drug dependence is connected with abnormal functional organization in the individual’s brain. The present study aimed to identify the anterior cingulate cortex (ACC) abnormali...

    Authors: Tao Liu, Jianjun Li, Zhongyan Zhao, Yuan Zhong, Zhiqiang Zhang, Qiang Xu, Guoshuai Yang, Guangming Lu, Suyue Pan and Feng Chen
    Citation: Journal of Translational Medicine 2016 14:33
  33. Autosomal recessive non-syndromic hearing loss (ARNSHL) is highly heterogeneous, and mutations in the gene encoding transmembrane channel-like 1 (TMC1) have been implicated in its development. To date, 35 homo...

    Authors: Jiongjiong Hu, Fei Liu, Wenjun Xia, Lili Hao, Jun Lan, Zhenghua Zhu, Jing Ye, Duan Ma and Zhaoxin Ma
    Citation: Journal of Translational Medicine 2016 14:29
  34. Preclinical trials have shown beneficial effects of nerve growth factor (NGF) administration on visual function in animal models of retinitis pigmentosa (RP). The aim of this pilot study was to explore the po...

    Authors: Benedetto Falsini, Giancarlo Iarossi, Antonio Chiaretti, Antonio Ruggiero, Luigi Manni, Lucia Galli-Resta, Giovanni Corbo and Edoardo Abed
    Citation: Journal of Translational Medicine 2016 14:8

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:43

  35. Parkinson’s disease (PD) is well documented to be associated with elevated systemic oxidative stress and perceptual impairments. Furthermore, the striatum and extrastriatal cortical areas, which are involved i...

    Authors: Wei-Che Lin, Kun-Hsien Chou, Pei-Lin Lee, Yung-Cheng Huang, Nai-Wen Tsai, Hsiu-Ling Chen, Kuei-Yueh Cheng, Hung-Chen Wang, Tsu-Kung Lin, Shau-Hsuan Li, Meng-Hsiang Chen, Cheng-Hsien Lu and Ching-Po Lin
    Citation: Journal of Translational Medicine 2015 13:386
  36. Autophagy is demonstrated to be involved in acute ischemic stroke(AIS), which, however, is confined to cells and/or animals levels. The aim of this study was to determine two autophagy biomarkers, Beclin1 and ...

    Authors: Honghong Li, Shuwei Qiu, Xiangpen Li, Mei Li and Ying Peng
    Citation: Journal of Translational Medicine 2015 13:359
  37. There is a paucity of effective therapies for recurrent/aggressive meningiomas. Establishment of improved in vitro and in vivo meningioma models will facilitate development and testing of novel therapeutic app...

    Authors: Sharon K Michelhaugh, Anthony R Guastella, Kaushik Varadarajan, Neil V Klinger, Prahlad Parajuli, Aamir Ahmad, Seema Sethi, Amro Aboukameel, Sam Kiousis, Ian M Zitron, Salah A Ebrahim, Lisa A Polin, Fazlul H Sarkar, Aliccia Bollig-Fischer and Sandeep Mittal
    Citation: Journal of Translational Medicine 2015 13:227
  38. Schizophrenia is a widespread and debilitating mental disorder. However, the underlying molecular mechanism of schizophrenia remains largely unknown and no objective laboratory tests are available to diagnose ...

    Authors: Mei-Ling Liu, Xiao-Tong Zhang, Xiang-Yu Du, Zheng Fang, Zhao Liu, Yi Xu, Peng Zheng, Xue-Jiao Xu, Peng-Fei Cheng, Ting Huang, Shun-Jie Bai, Li-Bo Zhao, Zhi-Guo Qi, Wei-Hua Shao and Peng Xie
    Citation: Journal of Translational Medicine 2015 13:226
  39. Rodents are incapable of emesis and consequently the emetic potential of glucagon-like peptide-1 receptor (GLP-1R) agonists in studies designed to assess a potential blood glucose lowering action of the compou...

    Authors: Zengbing Lu, Nathalie Percie Du Sert, Sze Wa Chan, Chi-Kong Yeung, Ge Lin, David TW Yew, Paul LR Andrews and John A Rudd
    Citation: Journal of Translational Medicine 2014 12:327
  40. A cochlear implant (CI) is an artificial hearing device that can replace a damaged cochlea. The present study examined the use of growth factor-eluting gelatin hydrogel coatings on the electrodes to minimize i...

    Authors: Yayoi S Kikkawa, Takayuki Nakagawa, Lin Ying, Yasuhiko Tabata, Hirohito Tsubouchi, Akio Ido and Juichi Ito
    Citation: Journal of Translational Medicine 2014 12:280
  41. our objective was to examine the plasma levels of three biological markers involved in cerebral ischemia (IL-6, glutamate and TNF-alpha) in stroke patients and compare them with two different rat models of foc...

    Authors: Patricia Martínez-Sánchez, María Gutiérrez-Fernández, Blanca Fuentes, Jaime Masjuán, María Alonso de Leciñana Cases, Maria Elena Novillo-López and Exuperio Díez-Tejedor
    Citation: Journal of Translational Medicine 2014 12:220
  42. Prevailingly, adult mammalian neurogenesis is thought to occur in discrete, separate locations known as neurogenic niches that are best characterized in the subgranular zone (SGZ) of the dentate gyrus and in t...

    Authors: Adriano Barreto Nogueira, Mari Cleide Sogayar, Alison Colquhoun, Sheila Aparecida Siqueira, Ariel Barreto Nogueira, Paulo Eurípedes Marchiori and Manoel Jacobsen Teixeira
    Citation: Journal of Translational Medicine 2014 12:75
  43. Racial and regional factors are important for the clinical diagnosis of non-syndromic hearing impairment. Comprehensive genetic analysis of deaf patients in different regions of China must be performed to prov...

    Authors: Kaitian Chen, Ling Zong, Min Liu, Xianren Wang, Wei Zhou, Yuan Zhan, Hui Cao, Chang Dong, Haocheng Tang and Hongyan Jiang
    Citation: Journal of Translational Medicine 2014 12:64
  44. Inherited genetic defects play an important role in congenital hearing loss, contributing to about 60% of deafness occurring in infants. Hereditary nonsyndromic hearing loss is highly heterogeneous, and most p...

    Authors: Xue Gao, Qing-yan Zhu, Yue-Shuai Song, Guo-Jian Wang, Yong-Yi Yuan, Feng Xin, Sha-Sha Huang, Dong-Yang Kang, Ming-Yu Han, Li-ping Guan, Jian-guo Zhang and Pu Dai
    Citation: Journal of Translational Medicine 2013 11:284
  45. MicroRNAs have recently emerged as key regulators of cancers, miR-329 located on 14q32.31 is one of down-regulated miRNAs in glioma, but the function and molecular mechanisms of miR-329 in determining the mali...

    Authors: Bingxiang Xiao, Li Tan, Benfu He, Zhiliang Liu and Ruxiang Xu
    Citation: Journal of Translational Medicine 2013 11:172
  46. When patients with ocular motor deficits come to the clinic, in numerous situations it is hard to relate their behavior to one or several deficient neural structures. We sought to demonstrate that neuromimetic...

    Authors: Pierre M Daye, Lance M Optican, Emmanuel Roze, Bertrand Gaymard and Pierre Pouget
    Citation: Journal of Translational Medicine 2013 11:125
  47. Neurodegenerative diseases such as Alzheimer’s are associated with the aggregation of endogenous peptides and proteins that contribute to neuronal dysfunction and loss. The glymphatic system, a brain-wide peri...

    Authors: Lijun Yang, Benjamin T Kress, Harris J Weber, Meenakshisundaram Thiyagarajan, Baozhi Wang, Rashid Deane, Helene Benveniste, Jeffrey J Iliff and Maiken Nedergaard
    Citation: Journal of Translational Medicine 2013 11:107
  48. Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. Kv7 channels are expressed along myelinated and unmyelinated peripheral axons where their activation is expecte...

    Authors: Johannes Fleckenstein, Ruth Sittl, Beate Averbeck, Philip M Lang, Dominik Irnich and Richard W Carr
    Citation: Journal of Translational Medicine 2013 11:34

Annual Journal Metrics

  • 2022 Citation Impact
    7.4 - 2-year Impact Factor
    6.9 - 5-year Impact Factor
    1.458 - SNIP (Source Normalized Impact per Paper)
    1.544 - SJR (SCImago Journal Rank)

    2022 Speed
    5 days submission to first editorial decision for all manuscripts (Median)
    84 days submission to accept (Median)

    2022 Usage 
    4,243,080 downloads
    32,614 Altmetric mentions