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Neuroscience

Section edited by Luis F. Alguacil

The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field.

Featured articles

Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study
Tao Liu, et al


NGF eye-drops topical administration in patients with retinitis pigmentosa, a pilot study
Benedetto Falsini, et al


Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1
Sharon K Michelhaugh, et al

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  1. A cochlear implant (CI) is an artificial hearing device that can replace a damaged cochlea. The present study examined the use of growth factor-eluting gelatin hydrogel coatings on the electrodes to minimize i...

    Authors: Yayoi S Kikkawa, Takayuki Nakagawa, Lin Ying, Yasuhiko Tabata, Hirohito Tsubouchi, Akio Ido and Juichi Ito

    Citation: Journal of Translational Medicine 2014 12:280

    Content type: Research

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  2. our objective was to examine the plasma levels of three biological markers involved in cerebral ischemia (IL-6, glutamate and TNF-alpha) in stroke patients and compare them with two different rat models of foc...

    Authors: Patricia Martínez-Sánchez, María Gutiérrez-Fernández, Blanca Fuentes, Jaime Masjuán, María Alonso de Leciñana Cases, Maria Elena Novillo-López and Exuperio Díez-Tejedor

    Citation: Journal of Translational Medicine 2014 12:220

    Content type: Research

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  3. Prevailingly, adult mammalian neurogenesis is thought to occur in discrete, separate locations known as neurogenic niches that are best characterized in the subgranular zone (SGZ) of the dentate gyrus and in t...

    Authors: Adriano Barreto Nogueira, Mari Cleide Sogayar, Alison Colquhoun, Sheila Aparecida Siqueira, Ariel Barreto Nogueira, Paulo Eurípedes Marchiori and Manoel Jacobsen Teixeira

    Citation: Journal of Translational Medicine 2014 12:75

    Content type: Research

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  4. Racial and regional factors are important for the clinical diagnosis of non-syndromic hearing impairment. Comprehensive genetic analysis of deaf patients in different regions of China must be performed to prov...

    Authors: Kaitian Chen, Ling Zong, Min Liu, Xianren Wang, Wei Zhou, Yuan Zhan, Hui Cao, Chang Dong, Haocheng Tang and Hongyan Jiang

    Citation: Journal of Translational Medicine 2014 12:64

    Content type: Research

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  5. Inherited genetic defects play an important role in congenital hearing loss, contributing to about 60% of deafness occurring in infants. Hereditary nonsyndromic hearing loss is highly heterogeneous, and most p...

    Authors: Xue Gao, Qing-yan Zhu, Yue-Shuai Song, Guo-Jian Wang, Yong-Yi Yuan, Feng Xin, Sha-Sha Huang, Dong-Yang Kang, Ming-Yu Han, Li-ping Guan, Jian-guo Zhang and Pu Dai

    Citation: Journal of Translational Medicine 2013 11:284

    Content type: Research

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  6. MicroRNAs have recently emerged as key regulators of cancers, miR-329 located on 14q32.31 is one of down-regulated miRNAs in glioma, but the function and molecular mechanisms of miR-329 in determining the mali...

    Authors: Bingxiang Xiao, Li Tan, Benfu He, Zhiliang Liu and Ruxiang Xu

    Citation: Journal of Translational Medicine 2013 11:172

    Content type: Research

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  7. When patients with ocular motor deficits come to the clinic, in numerous situations it is hard to relate their behavior to one or several deficient neural structures. We sought to demonstrate that neuromimetic...

    Authors: Pierre M Daye, Lance M Optican, Emmanuel Roze, Bertrand Gaymard and Pierre Pouget

    Citation: Journal of Translational Medicine 2013 11:125

    Content type: Research

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  8. Neurodegenerative diseases such as Alzheimer’s are associated with the aggregation of endogenous peptides and proteins that contribute to neuronal dysfunction and loss. The glymphatic system, a brain-wide peri...

    Authors: Lijun Yang, Benjamin T Kress, Harris J Weber, Meenakshisundaram Thiyagarajan, Baozhi Wang, Rashid Deane, Helene Benveniste, Jeffrey J Iliff and Maiken Nedergaard

    Citation: Journal of Translational Medicine 2013 11:107

    Content type: Methodology

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  9. Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. Kv7 channels are expressed along myelinated and unmyelinated peripheral axons where their activation is expecte...

    Authors: Johannes Fleckenstein, Ruth Sittl, Beate Averbeck, Philip M Lang, Dominik Irnich and Richard W Carr

    Citation: Journal of Translational Medicine 2013 11:34

    Content type: Research

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  10. Alzheimer’s Disease (AD) is the most widespread form of dementia in the elderly but despite progress made in recent years towards a mechanistic understanding, there is still an urgent need for disease modifica...

    Authors: Ines Greco, Nicola Day, Joanna Riddoch-Contreras, Jane Reed, Hilkka Soininen, Iwona Kłoszewska, Magda Tsolaki, Bruno Vellas, Christian Spenger, Patrizia Mecocci, Lars-Olof Wahlund, Andrew Simmons, Julie Barnes and Simon Lovestone

    Citation: Journal of Translational Medicine 2012 10:217

    Content type: Research

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  11. We reviewed the early development of various focal ischemia models in spontaneously hypertensive rats (SHR), and summarized recent reports on this topic. Among 6 focal ischemia models established in divergent ...

    Authors: Hiroshi Yao and Toru Nabika

    Citation: Journal of Translational Medicine 2012 10:139

    Content type: Review

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  12. Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder with gender biased and incomplete penetrance. The majority of LHON patients are caused by one of the three primary mutations (m.3460G > A, m...

    Authors: A-Mei Zhang, Xiaoyun Jia, Xiangming Guo, Qingjiong Zhang and Yong-Gang Yao

    Citation: Journal of Translational Medicine 2012 10:43

    Content type: Research

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  13. Methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter is a favorable prognostic factor in glioblastoma patients. However, reported methylation frequencies vary significantly partly due to...

    Authors: Annette Bentsen Håvik, Petter Brandal, Hilde Honne, Hanne-Sofie Spenning Dahlback, David Scheie, Merete Hektoen, Torstein Ragnar Meling, Eirik Helseth, Sverre Heim, Ragnhild A Lothe and Guro Elisabeth Lind

    Citation: Journal of Translational Medicine 2012 10:36

    Content type: Research

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  14. Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker discovery. They can transfer information between cells and ma...

    Authors: Jonathan M Street, Perdita E Barran, C Logan Mackay, Stefan Weidt, Craig Balmforth, Tim S Walsh, Rod TA Chalmers, David J Webb and James W Dear

    Citation: Journal of Translational Medicine 2012 10:5

    Content type: Research

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  15. Aberrant expression of small noncoding RNAs called microRNAs (miRNAs) is a common feature of several human diseases. The objective of the study was to identify miRNA modulation in patients with complex regiona...

    Authors: Irina A Orlova, Guillermo M Alexander, Rehman A Qureshi, Ahmet Sacan, Alessandro Graziano, James E Barrett, Robert J Schwartzman and Seena K Ajit

    Citation: Journal of Translational Medicine 2011 9:195

    Content type: Research

    Published on:

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