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Journal of Translational Medicine

Neuroscience

Section edited by Luis F. Alguacil

The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field.

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  1. Content type: Research

    Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. Kv7 channels are expressed along myelinated and unmyelinated peripheral axons where their activation is expecte...

    Authors: Johannes Fleckenstein, Ruth Sittl, Beate Averbeck, Philip M Lang, Dominik Irnich and Richard W Carr

    Citation: Journal of Translational Medicine 2013 11:34

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  2. Content type: Research

    Alzheimer’s Disease (AD) is the most widespread form of dementia in the elderly but despite progress made in recent years towards a mechanistic understanding, there is still an urgent need for disease modifica...

    Authors: Ines Greco, Nicola Day, Joanna Riddoch-Contreras, Jane Reed, Hilkka Soininen, Iwona Kłoszewska, Magda Tsolaki, Bruno Vellas, Christian Spenger, Patrizia Mecocci, Lars-Olof Wahlund, Andrew Simmons, Julie Barnes and Simon Lovestone

    Citation: Journal of Translational Medicine 2012 10:217

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  3. Content type: Review

    We reviewed the early development of various focal ischemia models in spontaneously hypertensive rats (SHR), and summarized recent reports on this topic. Among 6 focal ischemia models established in divergent ...

    Authors: Hiroshi Yao and Toru Nabika

    Citation: Journal of Translational Medicine 2012 10:139

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  4. Content type: Research

    Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder with gender biased and incomplete penetrance. The majority of LHON patients are caused by one of the three primary mutations (m.3460G > A, m...

    Authors: A-Mei Zhang, Xiaoyun Jia, Xiangming Guo, Qingjiong Zhang and Yong-Gang Yao

    Citation: Journal of Translational Medicine 2012 10:43

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  5. Content type: Research

    Methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter is a favorable prognostic factor in glioblastoma patients. However, reported methylation frequencies vary significantly partly due to...

    Authors: Annette Bentsen Håvik, Petter Brandal, Hilde Honne, Hanne-Sofie Spenning Dahlback, David Scheie, Merete Hektoen, Torstein Ragnar Meling, Eirik Helseth, Sverre Heim, Ragnhild A Lothe and Guro Elisabeth Lind

    Citation: Journal of Translational Medicine 2012 10:36

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  6. Content type: Research

    Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker discovery. They can transfer information between cells and ma...

    Authors: Jonathan M Street, Perdita E Barran, C Logan Mackay, Stefan Weidt, Craig Balmforth, Tim S Walsh, Rod TA Chalmers, David J Webb and James W Dear

    Citation: Journal of Translational Medicine 2012 10:5

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  7. Content type: Research

    Aberrant expression of small noncoding RNAs called microRNAs (miRNAs) is a common feature of several human diseases. The objective of the study was to identify miRNA modulation in patients with complex regiona...

    Authors: Irina A Orlova, Guillermo M Alexander, Rehman A Qureshi, Ahmet Sacan, Alessandro Graziano, James E Barrett, Robert J Schwartzman and Seena K Ajit

    Citation: Journal of Translational Medicine 2011 9:195

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