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Immunobiology and Immunotherapy

Section edited by Alessandra Cesano

The Immunobiology and Immunotherapy section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Pedro Romero was the founding Section Editor.

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  1. Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard the...

    Authors: Linda M. Liau, Keyoumars Ashkan, David D. Tran, Jian L. Campian, John E. Trusheim, Charles S. Cobbs, Jason A. Heth, Michael Salacz, Sarah Taylor, Stacy D. D’Andre, Fabio M. Iwamoto, Edward J. Dropcho, Yaron A. Moshel, Kevin A. Walter, Clement P. Pillainayagam, Robert Aiken…
    Citation: Journal of Translational Medicine 2018 16:142
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:179

  2. Ipilimumab is a licensed immunotherapy for metastatic melanoma patients and, in the US, as adjuvant treatment for high risk melanoma radically resected. The use of ipilimumab is associated with a typical but u...

    Authors: Sara Valpione, Sandro Pasquali, Luca Giovanni Campana, Luisa Piccin, Simone Mocellin, Jacopo Pigozzo and Vanna Chiarion-Sileni
    Citation: Journal of Translational Medicine 2018 16:94
    Content type: Research Published on:

  3. “Avoiding immune destruction” has recently been established as one of the hallmarks of cancer. The programmed cell death (PD)-1/programmed cell death-ligand (PD-L) 1 pathway is an important immunosuppression m...

    Authors: Yuka Asano, Shinichiro Kashiwagi, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira
    Citation: Journal of Translational Medicine 2018 16:87
    Content type: Research Published on:

  4. The aim of this study was to investigate the mechanisms of OX40L in regulating helper T (Th) cells differentiation through phosphoinositide 3-kinase (PI3K)/AKT and p38 mitogen-activated protein kinase signalin...

    Authors: Li Huang, Meijuan Wang, Yongdong Yan, Wenjing Gu, Xinxing Zhang, Jiahong Tan, Huiming Sun, Wei Ji and Zhengrong Chen
    Citation: Journal of Translational Medicine 2018 16:74
    Content type: Research Published on:

  5. Fibrinogen is a central player in the blood coagulation cascade and one of the most abundant plasma proteins. This glycoprotein also triggers important events (e.g., cell spreading, the respiratory burst and d...

    Authors: Tiziana Alberio, Greta Forlani, Marta Lualdi, Giovanna Tosi, Roberto S. Accolla and Mauro Fasano
    Citation: Journal of Translational Medicine 2018 16:64
    Content type: Research Published on:

  6. Shigellosis persists as a public health problem worldwide causing ~ 165,000 deaths every year, of which ~ 55,000 are in children less than 5 years of age. No vaccine against shigellosis is currently licensed. ...

    Authors: Franklin R. Toapanta, Paula J. Bernal, Karen L. Kotloff, Myron M. Levine and Marcelo B. Sztein
    Citation: Journal of Translational Medicine 2018 16:61
    Content type: Research Published on:

  7. Th17 cells and its effective cytokine IL-17A play an important role in the pathogenesis of abnormal immune responses in psoriasis. Notch1 signaling has been implicated in Th17 cell differentiation and function...

    Authors: Lei Ma, Haibo Xue, Ruiqun Qi, Yanqin Wang and Libing Yuan
    Citation: Journal of Translational Medicine 2018 16:59
    Content type: Research Published on:

  8. An altered gut microbiota balance is involved in the pathogenesis of inflammatory bowel disease (IBD), and several probiotic strains are used as dietary supplements to improve intestinal health. We evaluated t...

    Authors: Jin-Sil Park, JeongWon Choi, Ji Ye Kwon, Kyung-Ah Jung, Chul Woo Yang, Sung-Hwan Park and Mi-La Cho
    Citation: Journal of Translational Medicine 2018 16:37
    Content type: Research Published on:

  9. During infection with human cytomegalovirus (HCMV) several viral proteins occur on cell surfaces in high quantity. We thus pursue an HLA-independent approach for immunotherapy of HCMV using chimeric antigen re...

    Authors: Julia Proff, Charlotte U. Brey, Armin Ensser, Wolfgang Holter and Manfred Lehner
    Citation: Journal of Translational Medicine 2018 16:26
    Content type: Research Published on:

  10. Cancer vaccines can effectively establish clinically relevant tumor immunity. Novel sequencing approaches rapidly identify the mutational fingerprint of tumors, thus allowing to generate personalized tumor vac...

    Authors: Katja Sonntag, Hisayoshi Hashimoto, Matthias Eyrich, Moritz Menzel, Max Schubach, Dennis Döcker, Florian Battke, Carolina Courage, Helmut Lambertz, Rupert Handgretinger, Saskia Biskup and Karin Schilbach
    Citation: Journal of Translational Medicine 2018 16:23
    Content type: Research Published on:

  11. Myeloid-derived suppressor cells (MDSCs) are a series of innate cells that play a significant role in inhibiting T cell-related responses. This heterogeneous population of immature cells is involved in tumor i...

    Authors: Weitao Zhang, Jiawei Li, Guisheng Qi, Guowei Tu, Cheng Yang and Ming Xu
    Citation: Journal of Translational Medicine 2018 16:19
    Content type: Review Published on:

  12. There is a pressing need in rheumatoid arthritis (RA) to identify patients who will not respond to first-line disease-modifying anti-rheumatic drugs (DMARD). We explored whether differences in genomic architec...

    Authors: Claudio Carini, Ewan Hunter, Aroul S. Ramadass, Jayne Green, Alexandre Akoulitchev, Iain B. McInnes and Carl S. Goodyear
    Citation: Journal of Translational Medicine 2018 16:18
    Content type: Research Published on:

  13. Genetic engineering of T-cells to express specific T cell receptors (TCR) has emerged as a novel strategy to treat various malignancies. More widespread utilization of these types of therapies has been somewha...

    Authors: Jianjian Jin, Nikolaos Gkitsas, Vicki S. Fellowes, Jiaqiang Ren, Steven A. Feldman, Christian S. Hinrichs, David F. Stroncek and Steven L. Highfill
    Citation: Journal of Translational Medicine 2018 16:13
    Content type: Research Published on:

  14. γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity. As a bridge between the innate and adaptive immune syst...

    Authors: Yijing Zhao, Chao Niu and Jiuwei Cui
    Citation: Journal of Translational Medicine 2018 16:3
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:122

  15. Cytokine disturbances have been suggested to be associated with the Chronic Fatigue Syndrome/Myalgic encephalomyelitis (CFS/ME) for decades.

    Authors: Megan E. Roerink, Hans Knoop, Ewald M. Bronkhorst, Henk A. Mouthaan, Luuk J. A. C. Hawinkels, Leo A. B. Joosten and Jos W. M. van der Meer
    Citation: Journal of Translational Medicine 2017 15:267
    Content type: Research Published on:

  16. Ulcerative colitis (UC) is a highly progressive inflammatory disease that requires the interaction of epithelial, immune, endothelial and muscle cells and fibroblasts. Previous studies suggested two inflammato...

    Authors: Henrika Jodeleit, Pia Palamides, Florian Beigel, Thomas Mueller, Eckhard Wolf, Matthias Siebeck and Roswitha Gropp
    Citation: Journal of Translational Medicine 2017 15:265
    Content type: Research Published on:

  17. Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a re...

    Authors: Vegard Bruun Wyller, Chinh Bkrong Nguyen, Judith Anita Ludviksen and Tom Eirik Mollnes
    Citation: Journal of Translational Medicine 2017 15:245
    Content type: Research Published on:

  18. Nivolumab is an anti-PD1 checkpoint inhibitor active in patients with advanced melanoma and as adjuvant therapy in high-risk metastatic melanoma patients.

    Authors: Silvana Morello, Mariaelena Capone, Claudia Sorrentino, Diana Giannarelli, Gabriele Madonna, Domenico Mallardo, Antonio M. Grimaldi, Aldo Pinto and Paolo Antonio Ascierto
    Citation: Journal of Translational Medicine 2017 15:244
    Content type: Research Published on:

  19. Understanding immune phenotypes and human gastric disease in situ requires an approach that leverages multiplexed immunohistochemistry (mIHC) with multispectral imaging to facilitate precise image analyses.

    Authors: Le Ying, Feng Yan, Qiaohong Meng, Xiangliang Yuan, Liang Yu, Bryan R. G. Williams, David W. Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Dakang Xu and Yiqun Hu
    Citation: Journal of Translational Medicine 2017 15:206
    Content type: Research Published on:

  20. The complex interactions between the immune system and tumors lead the identification of key molecules that govern these interactions: immunotherapeutics were designed to overcome the mechanisms broken by tumo...

    Authors: Paolo A. Ascierto, Bruno Daniele, Hans Hammers, Vera Hirsh, Joseph Kim, Lisa Licitra, Rita Nanda and Sandro Pignata
    Citation: Journal of Translational Medicine 2017 15:205
    Content type: Meeting report Published on:

  21. The current BCG vaccine induces only short-term protection against Mycobacterium tuberculosis (Mtb), suggesting its failure to generate long-lasting memory T cells. Previously, we have demonstrated that a self-ad...

    Authors: Pradeep K. Rai, Sathi Babu Chodisetti, Weiguang Zeng, Sajid Nadeem, Sudeep K. Maurya, Susanta Pahari, Ashok K. Janmeja, David C. Jackson and Javed N. Agrewala
    Citation: Journal of Translational Medicine 2017 15:201
    Content type: Research Published on:

  22. A small proportion of HIV-infected patients remain clinically and/or immunologically stable for years, including elite controllers (ECs) who have undetectable viremia (<50 copies/ml) and long-term nonprogresso...

    Authors: Le-Le Zhang, Zi-Ning Zhang, Xian Wu, Yong-Jun Jiang, Ya-Jing Fu and Hong Shang
    Citation: Journal of Translational Medicine 2017 15:191
    Content type: Research Published on:

  23. Our research is focused on using the vaccine draining lymph node to better understand the immune response to cancer vaccines and as a possible source of anti-cancer reagents. We evaluated vaccine draining lymp...

    Authors: Girja S. Shukla, Walter C. Olson, Stephanie C. Pero, Yu-jing Sun, Chelsea L. Carman, Craig L. Slingluff Jr. and David N. Krag
    Citation: Journal of Translational Medicine 2017 15:180
    Content type: Research Published on:

  24. The success of immunotherapeutics in oncology and the search for further improvements has prompted revisiting the use of cancer vaccines. In this context, knowledge of the immunogenic epitopes and the monitori...

    Authors: Tanja Scheikl-Gatard, Caroline Tosch, François Lemonnier and Ronald Rooke
    Citation: Journal of Translational Medicine 2017 15:154
    Content type: Research Published on:

  25. Thanks to striking progress in both the understanding of anti-tumor immune response and the characterization of several tumor associated antigens (TAA), a more rational design and more sophisticated strategies...

    Authors: Valeria Rolih, Giuseppina Barutello, Selina Iussich, Raffaella De Maria, Elena Quaglino, Paolo Buracco, Federica Cavallo and Federica Riccardo
    Citation: Journal of Translational Medicine 2017 15:151
    Content type: Review Published on:

  26. Immunotherapy consists of activating the patient’s immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have eme...

    Authors: Michele Graciotti, Cristiana Berti, Harm-Anton Klok and Lana Kandalaft
    Citation: Journal of Translational Medicine 2017 15:142
    Content type: Review Published on:

  27. Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high...

    Authors: Kevin Hollevoet and Paul J. Declerck
    Citation: Journal of Translational Medicine 2017 15:131
    Content type: Review Published on:

  28. Invariant natural killer T (iNKT) cells are a small population of lymphocytes with unique specificity for glycolipid antigens presented by non-polymorphic CD1d receptor on dendritic cells (DCs). iNKT cells pla...

    Authors: Laura Escribà-Garcia, Carmen Alvarez-Fernández, Marta Tellez-Gabriel, Jorge Sierra and Javier Briones
    Citation: Journal of Translational Medicine 2017 15:115
    Content type: Research Published on:

  29. The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the ...

    Authors: Liang Li, Mubing Duan, Weisan Chen, An Jiang, Xiaoming Li, Jun Yang and Zongfang Li
    Citation: Journal of Translational Medicine 2017 15:111
    Content type: Review Published on:

  30. Prognosis of patients with glioblastoma multiforme (GBM) remains dismal, with median overall survival (OS) of about 15 months. It is therefore crucial to search alternative strategies that improve these result...

    Authors: Susana Inogés, Sonia Tejada, Ascensión López-Díaz de Cerio, Jaime Gállego Pérez-Larraya, Jaime Espinós, Miguel Angel Idoate, Pablo Daniel Domínguez, Reyes García de Eulate, Javier Aristu, Maurizio Bendandi, Fernando Pastor, Marta Alonso, Enrique Andreu, Felipe Prósper Cardoso and Ricardo Díez Valle
    Citation: Journal of Translational Medicine 2017 15:104
    Content type: Research Published on:

  31. Chronic fatigue syndrome (CFS) is a prevalent and disabling condition affecting adolescents. The pathophysiology is poorly understood, but immune alterations might be an important component. This study compare...

    Authors: Chinh Bkrong Nguyen, Lene Alsøe, Jessica M. Lindvall, Dag Sulheim, Even Fagermoen, Anette Winger, Mari Kaarbø, Hilde Nilsen and Vegard Bruun Wyller
    Citation: Journal of Translational Medicine 2017 15:102
    Content type: Research Published on:

  32. Hydrogen sulfide (H2S), previously only considered a toxic environmental air pollutant, is now increasingly recognized as an important signaling molecule able to modulate several cellular pathways in many human t...

    Authors: Francesca Benedetti, Sabrina Curreli, Selvi Krishnan, Sergio Davinelli, Fiorenza Cocchi, Giovanni Scapagnini, Robert C. Gallo and Davide Zella
    Citation: Journal of Translational Medicine 2017 15:100
    Content type: Review Published on:

  33. Malignant melanoma is an aggressive tumor sensitive for immunotherapy such as checkpoint blockade antibodies. Still, most patients with late stage disease do not respond, and the side effects can be severe. St...

    Authors: A. Schiza, J. Wenthe, S. Mangsbo, E. Eriksson, Anders Nilsson, T. H. Tötterman, A. Loskog and G. Ullenhag
    Citation: Journal of Translational Medicine 2017 15:79
    Content type: Research Published on:

  34. Liver fibrosis which mainly occurs upon chronic hepatitis virus infection potentially leads to portal hypertension, hepatic failure and hepatocellular carcinoma. However, the immune status of Th17 and Treg cel...

    Authors: Xiaoyan Li, Yujie Su, Xuefeng Hua, Chan Xie, Jing Liu, Yuehua Huang, Liang Zhou, Min Zhang, Xu Li and Zhiliang Gao
    Citation: Journal of Translational Medicine 2017 15:75
    Content type: Research Published on:

  35. Tuberculin skin test based on in vivo intradermal inoculation of purified protein derivative from Mycobacterium bovis (bPPD) is the diagnostic test for the control and surveillance of bovine tuberculosis (bTB).

    Authors: Sante Roperto, Mariaconcetta Varano, Valeria Russo, Roberta Lucà, Monica Cagiola, Marco Gaspari, Dora Maria Ceccarelli, Giovanni Cuda and Franco Roperto
    Citation: Journal of Translational Medicine 2017 15:68
    Content type: Research Published on:

  36. Lymphocyte expansion and true lymphocytosis are commonly observed in the everyday clinical practice. The meaning of such phenomenon is often poorly understood so that discrimination between benign and malignan...

    Authors: Andrea Picchianti Diamanti, Bruno Laganà, Maria Christina Cox, Emanuela Pilozzi, Rachele Amodeo, Maurizio Bove, Milica Markovic, Roberta Di Rosa, Simonetta Salemi, Maria Laura Sorgi, Maria Manuela Rosado and Raffaele D’Amelio
    Citation: Journal of Translational Medicine 2017 15:38
    Content type: Research Published on:

  37. Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known re...

    Authors: Kely Campos Navegantes, Rafaelli de Souza Gomes, Priscilla Aparecida Tártari Pereira, Paula Giselle Czaikoski, Carolina Heitmann Mares Azevedo and Marta Chagas Monteiro
    Citation: Journal of Translational Medicine 2017 15:36
    Content type: Review Published on:

  38. Leflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, t...

    Authors: Su-Jin Moon, Eun-Kyung Kim, Joo Yeon Jhun, Hee Jin Lee, Weon Sun Lee, Sang-Hi Park, Mi-La Cho and Jun-Ki Min
    Citation: Journal of Translational Medicine 2017 15:31
    Content type: Research Published on:

  39. Keratitis is a common cause of blindness. Current anti-inflammatory drugs used in keratitis have profound side effects. Small peptides derived from endogenous proteins potentially display both desired efficien...

    Authors: Shaopin Zhu, Xun Xu, Lili Wang, Li Su, Qing Gu, Fang Wei and Kun Liu
    Citation: Journal of Translational Medicine 2017 15:20
    Content type: Research Published on:

  40. Due to their self-renewal capacity, multi-lineage potential, and immunomodulatory properties, mesenchymal stromal cells (MSCs) are an attractive tool for different therapeutic strategies. Foreskin (FSK), consi...

    Authors: Hussein Fayyad-Kazan, Mohammad Fayyad-Kazan, Bassam Badran, Dominique Bron, Laurence Lagneaux and Mehdi Najar
    Citation: Journal of Translational Medicine 2017 15:10
    Content type: Research Published on:

  41. Prophylactic and therapeutic vaccines often depend upon a strong activation of the innate immune system to drive a potent adaptive immune response, often mediated by a strong adjuvant. For a number of adjuvant...

    Authors: Darin K. Edwards, Edith Jasny, Heesik Yoon, Nigel Horscroft, Brian Schanen, Tanya Geter, Mariola Fotin-Mleczek, Benjamin Petsch and Vaughan Wittman
    Citation: Journal of Translational Medicine 2017 15:1
    Content type: Research Published on:

  42. The mechanisms by which vaccinia virus (VACV) interacts with the innate immune components are complex and involve different mechanisms. iNOS-mediated NO production by myeloid cells is one of the central antivi...

    Authors: Mehmet Okyay Kilinc, Klaas Ehrig, Maysam Pessian, Boris R. Minev and Aladar A. Szalay
    Citation: Journal of Translational Medicine 2016 14:340
    Content type: Research Published on:

  43. An infection-immune association of periodontal disease with rheumatoid arthritis has been suggested. This study aimed to investigate the effect of pre-existing periodontitis on the development and the immune/i...

    Authors: Kaja Eriksson, Erik Lönnblom, Gregory Tour, Anna Kats, Piotr Mydel, Pierre Georgsson, Catharina Hultgren, Nastya Kharlamova, Ulrika Norin, Jörgen Jönsson, Anna Lundmark, Annelie Hellvard, Karin Lundberg, Leif Jansson, Rikard Holmdahl and Tülay Yucel-Lindberg
    Citation: Journal of Translational Medicine 2016 14:311
    Content type: Research Published on:

  44. Chemokines and chemokine receptors play important roles in autoimmune diseases; however, their role in immune thrombocytopenia (ITP) is unclear. High-dose dexamethasone (HD-DXM) may become a first-line therapy...

    Authors: Zongtang Liu, Meiying Wang, Shufen Zhou, Ji Ma, Yan Shi, Jun Peng, Ming Hou and Chengshan Guo
    Citation: Journal of Translational Medicine 2016 14:301
    Content type: Research Published on:

  45. Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Efficient antiviral T-cell responses are necessary to clear infect...

    Authors: Sabine Tischer, René Geyeregger, Julian Kwoczek, Albert Heim, Constanca Figueiredo, Rainer Blasczyk, Britta Maecker-Kolhoff and Britta Eiz-Vesper
    Citation: Journal of Translational Medicine 2016 14:286
    Content type: Research Published on:

  46. Asthma is prone to Th2-mediated chronic airway inflammation. Interleukin-27 (IL-27) is a member of the IL-12 family that promotes the differentiation of Th1 cells and inhibits Th2 cells. We use human/mouse CD4+ T...

    Authors: Xiaoqiong Su, Jue Pan, Fengxi Bai, Honglei Yuan, Nian Dong, Dandan Li, Xiangdong Wang and Zhihong Chen
    Citation: Journal of Translational Medicine 2016 14:283
    Content type: Research Published on:

  47. Cancer immunotherapy can be potentiated by conditioning regimens such as cyclophosphamide, which reduces the level of regulatory T cells (tregs). However, myeloid suppressive cells are still remaining. Accordi...

    Authors: Emma Eriksson, Jessica Wenthe, Sandra Irenaeus, Angelica Loskog and Gustav Ullenhag
    Citation: Journal of Translational Medicine 2016 14:282
    Content type: Research Published on:

  48. Cytokine-induced-killer (CIK) cells are a promising immunotherapeutic approach for impending relapse following hematopoietic stem cell transplantation (HSCT). However, there is a high risk for treatment failur...

    Authors: Melanie Bremm, Sabine Huenecke, Olga Zimmermann, Verena Pfirrmann, Andrea Quaiser, Halvard Bonig, Jan Soerensen, Thomas Klingebiel, Eva Rettinger, Peter Bader and Claudia Cappel
    Citation: Journal of Translational Medicine 2016 14:264
    Content type: Research Published on:

  49. The Vk*MYC transgenic and transplant mouse models of multiple myeloma (MM) are well established as a research tool for anti-myeloma drug discovery. However, little is known of the immune response in these mode...

    Authors: Rachel E. Cooke, Nicholas A. Gherardin, Simon J. Harrison, Hang Quach, Dale I. Godfrey, Miles Prince, Rachel Koldej and David S. Ritchie
    Citation: Journal of Translational Medicine 2016 14:259
    Content type: Research Published on:

  50. Tumour resistance to a wide range of drugs (multiple drug resistant, MDR) acquired after intensive chemotherapy is considered to be the main obstacle of the curative treatment of cancer patients. Recent work h...

    Authors: Elena P. Goncharova, Julia S. Ruzhenkova, Ivan S. Petrov, Sergey N. Shchelkunov and Marina A. Zenkova
    Citation: Journal of Translational Medicine 2016 14:241
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:280

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