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Immunobiology and Immunotherapy

Section edited by Alessandra Cesano

The Immunobiology and Immunotherapy section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Pedro Romero was the founding Section Editor.

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  1. The onset of chronic fatigue syndrome (CFS) has been shown to be associated with several immunological conditions such as infections or atopy. The aim of this study was to clarify the risk of chronic fatigue s...

    Authors: Shin-Yi Tsai, Hsuan-Ju Chen, Chi Chen, Chon-Fu Lio, Chien-Feng Kuo, Kam-Hang Leong, Yu-Ting Tina Wang, Tse-Yen Yang, Ching-Hui You and Wei-Sheng Wang
    Citation: Journal of Translational Medicine 2019 17:154
    Content type: Research Published on:

  2. Targeting new molecular pathways leading to Osteoporosis (OP) and Osteoarthritis (OA) is a hot topic for drug discovery. Clusterin (CLU) is a glycoprotein involved in inflammation, proliferation, cell death, n...

    Authors: S. Pucci, C. Greggi, C. Polidoro, M. C. Piro, M. Celi, M. Feola, E. Gasbarra, R. Iundusi, F. Mastrangeli, G. Novelli, A. Orlandi and U. Tarantino
    Citation: Journal of Translational Medicine 2019 17:118
    Content type: Research Published on:

  3. Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease characterized by upregulation of inflammatory cell death and osteoclastogenesis. Necrostatin (NST)-1s is a chemical inhibitor of recepto...

    Authors: Jooyeon Jhun, Seung Hoon Lee, Se-Young Kim, Jaeyoon Ryu, Ji Ye Kwon, Hyun Sik Na, KyoungAh Jung, Su-Jin Moon, Mi-La Cho and Jun-Ki Min
    Citation: Journal of Translational Medicine 2019 17:84
    Content type: Research Published on:

  4. The morbidity of nephrolithiasis is 2–3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis. The death of renal tubular epithelial cells (TECs) is an important p...

    Authors: Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao and Yinghao Sun
    Citation: Journal of Translational Medicine 2019 17:62
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:146

  5. In 1975, Milstein and Köhler revolutionized the medical world with the development of the hybridoma technique to produce monoclonal antibodies. Since then, monoclonal antibodies have entered almost every branc...

    Authors: Lien Van Hoecke and Kenny Roose
    Citation: Journal of Translational Medicine 2019 17:54
    Content type: Review Published on:

  6. Immunology research, particularly next generation sequencing (NGS) of the immune T-cell receptor β (TCRβ) repertoire, has advanced progression in several fields, including treatment of various cancers and auto...

    Authors: Shang-Gin Wu, Wenjing Pan, Hongna Liu, Miranda L. Byrne-Steele, Brittany Brown, Mollye Depinet, Xiaohong Hou, Jian Han and Song Li
    Citation: Journal of Translational Medicine 2019 17:47
    Content type: Research Published on:

  7. Acute myocardial infarction (AMI) is characterized by an inflammatory process in which T cell plays a key role. However, the profile of immune microenvironment in AMI is still uncertain. High-throughput sequen...

    Authors: Dan Li, Longgang Hu, Qing Liang, Cuijuan Zhang, Yunzhen Shi, Bin Wang and Kejia Wang
    Citation: Journal of Translational Medicine 2019 17:40
    Content type: Research Published on:

  8. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the presence of pathogenic autoantibodies associated with polyclonal B cell hyperreactivity. Previous study reported that ...

    Authors: Meiyu Zhang, Chengcheng Yao, Jun Cai, Shuai Liu, Xia-nan Liu, Yingying Chen, Shujun Wang, Ping Ji, Meng Pan, Zizhen Kang and Ying Wang
    Citation: Journal of Translational Medicine 2019 17:37
    Content type: Research Published on:

  9. Tissue expansion is a procedure that promotes skin regeneration by mechanical stretch. During the stress and relaxation cycle, the skin undergoes a repeated microtrauma which triggers an immune response leadin...

    Authors: Jianke Ding, Lei Lei, Shiqiang Liu, Yu Zhang, Zhou Yu, Yingjun Su and Xianjie Ma
    Citation: Journal of Translational Medicine 2019 17:36
    Content type: Research Published on:

  10. Spondyloarthritis (SpA) is chronic inflammatory arthritis, and interleukin (IL)-17 is crucial in SpA pathogenesis. Type 17 helper T (Th17) cells are one of major IL-17-secreting cells. Signal transducer and ac...

    Authors: Hong-Ki Min, JeongWon Choi, Seon-Yeong Lee, Hyeon-Beom Seo, KyungAh Jung, Hyun Sik Na, Jun-Geol Ryu, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2019 17:18
    Content type: Research Published on:

  11. we have recently shown that Tel-eVax, a genetic vaccine targeting dog telomerase (dTERT) and based on Adenovirus (Ad)/DNA Electro-Gene-Transfer (DNA–EGT) technology can induce strong immune response and increa...

    Authors: Joseph A. Impellizeri, Alessandra Gavazza, Eliana Greissworth, Anna Crispo, Maurizio Montella, Gennaro Ciliberto, George Lubas and Luigi Aurisicchio
    Citation: Journal of Translational Medicine 2018 16:349
    Content type: Research Published on:

  12. The overlapping symptoms and pathophysiological similarities between burn injury and chronic fatigue syndrome (CFS) are noteworthy. Thus, this study explores the possible association between burn injury and th...

    Authors: Shin-Yi Tsai, Cheng-Li Lin, Shou-Chuan Shih, Cheng-Wei Hsu, Kam-Hang Leong, Chien-Feng Kuo, Chon-Fu Lio, Yu-Tien Chen, Yan-Jiun Hung and Leiyu Shi
    Citation: Journal of Translational Medicine 2018 16:342
    Content type: Research Published on:

  13. Temporal lobe epilepsy (TLE) is a common and often refractory brain disease that is closely correlated with inflammation. Alpha-methyl-l-tryptophan (AMT) is recognized as a surrogate marker for epilepsy, characte...

    Authors: Yanli Wang, Yanling Wang, Ran Sun, Xingrao Wu, Xu Chu, Shuhu Zhou, Xibin Hu, Lingyun Gao and Qingxia Kong
    Citation: Journal of Translational Medicine 2018 16:337
    Content type: Research Published on:

  14. With the exception of genotoxic oncology drugs, first-in-human, Phase 1 clinical studies of investigational drugs have traditionally been conducted in healthy volunteers (HVs). The primary goal of these studie...

    Authors: Joyson J. Karakunnel, Nam Bui, Latha Palaniappan, Keith T. Schmidt, Kenneth W. Mahaffey, Briggs Morrison, William D. Figg and Shivaani Kummar
    Citation: Journal of Translational Medicine 2018 16:336
    Content type: Review Published on:

  15. Epicutaneous immunotherapy (EPIT) is a new way of allergen administration that has a high rate of adherence and safety. The aim of this manuscript is to review clinical trials on EPIT for respiratory and food ...

    Authors: Susanna Esposito, Chiara Isidori, Alessandra Pacitto, Cristina Salvatori, Laura Sensi, Franco Frati, Giuseppe Di Cara and Francesco Marcucci
    Citation: Journal of Translational Medicine 2018 16:329
    Content type: Review Published on:

  16. The clinical trials conducted at Chingleput India suggest that BCG fails to protect against tuberculosis (TB) in TB-endemic population. Recent studies advocate that non-tuberculous mycobacteria and latent Mycobac...

    Authors: Pradeep K. Rai, Sathi Babu Chodisetti, Sudeep K. Maurya, Sajid Nadeem, Weiguang Zeng, Ashok K. Janmeja, David C. Jackson and Javed N. Agrewala
    Citation: Journal of Translational Medicine 2018 16:279
    Content type: Research Published on:

  17. Interleukin (IL)-37 has emerged as a novel anti-inflammatory cytokine that play an immunosuppressive role in regulating inflammatory response. This study aimed to measure IL-37 levels in the plasma and periphe...

    Authors: Miao Feng, Min Kang, Feng He, Zonghui Xiao, Zhewei Liu, Hailan Yao and Jianxin Wu
    Citation: Journal of Translational Medicine 2018 16:277
    Content type: Research Published on:

  18. NLRP3 inflammasome is involved in the inflammatory responses during acute lung injury (ALI). RIP3 triggered NLRP3 inflammasome activation independent of necroptosis induction has recently been documented. In t...

    Authors: Jingxian Chen, Shuang Wang, Rong Fu, Mianjing Zhou, Tengyue Zhang, Wenxu Pan, Niansheng Yang and Yuefang Huang
    Citation: Journal of Translational Medicine 2018 16:233
    Content type: Research Published on:

  19. The use of checkpoint inhibitors (ipilimumab, pembrolizumab, nivolumab) has revolutionised the treatment of metastatic melanoma. However still more than the half the patients do not respond to single-agent imm...

    Authors: Angus G. Dalgleish, Satvinder Mudan and Alberto Fusi
    Citation: Journal of Translational Medicine 2018 16:227
    Content type: Research Published on:

  20. Interest in single-cell transcriptomic analysis is growing rapidly, especially for profiling rare or heterogeneous populations of cells. In almost all reported works investigators have used live cells, which i...

    Authors: Jinguo Chen, Foo Cheung, Rongye Shi, Huizhi Zhou and Wenrui Lu
    Citation: Journal of Translational Medicine 2018 16:198
    Content type: Methodology Published on:

  21. The TGFβ-signaling pathway plays an important role in the pathogenesis of colorectal cancer (CRC). Loss of function of several genes within this pathway, such as bone morphogenetic proteins (BMPs) have been se...

    Authors: Andrew J. Pellatt, Lila E. Mullany, Jennifer S. Herrick, Lori C. Sakoda, Roger K. Wolff, Wade S. Samowitz and Martha L. Slattery
    Citation: Journal of Translational Medicine 2018 16:191
    Content type: Research Published on:

  22. Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard the...

    Authors: Linda M. Liau, Keyoumars Ashkan, David D. Tran, Jian L. Campian, John E. Trusheim, Charles S. Cobbs, Jason A. Heth, Michael Salacz, Sarah Taylor, Stacy D. D’Andre, Fabio M. Iwamoto, Edward J. Dropcho, Yaron A. Moshel, Kevin A. Walter, Clement P. Pillainayagam, Robert Aiken…
    Citation: Journal of Translational Medicine 2018 16:142
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:179

  23. Ipilimumab is a licensed immunotherapy for metastatic melanoma patients and, in the US, as adjuvant treatment for high risk melanoma radically resected. The use of ipilimumab is associated with a typical but u...

    Authors: Sara Valpione, Sandro Pasquali, Luca Giovanni Campana, Luisa Piccin, Simone Mocellin, Jacopo Pigozzo and Vanna Chiarion-Sileni
    Citation: Journal of Translational Medicine 2018 16:94
    Content type: Research Published on:

  24. “Avoiding immune destruction” has recently been established as one of the hallmarks of cancer. The programmed cell death (PD)-1/programmed cell death-ligand (PD-L) 1 pathway is an important immunosuppression m...

    Authors: Yuka Asano, Shinichiro Kashiwagi, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira
    Citation: Journal of Translational Medicine 2018 16:87
    Content type: Research Published on:

  25. The aim of this study was to investigate the mechanisms of OX40L in regulating helper T (Th) cells differentiation through phosphoinositide 3-kinase (PI3K)/AKT and p38 mitogen-activated protein kinase signalin...

    Authors: Li Huang, Meijuan Wang, Yongdong Yan, Wenjing Gu, Xinxing Zhang, Jiahong Tan, Huiming Sun, Wei Ji and Zhengrong Chen
    Citation: Journal of Translational Medicine 2018 16:74
    Content type: Research Published on:

  26. Fibrinogen is a central player in the blood coagulation cascade and one of the most abundant plasma proteins. This glycoprotein also triggers important events (e.g., cell spreading, the respiratory burst and d...

    Authors: Tiziana Alberio, Greta Forlani, Marta Lualdi, Giovanna Tosi, Roberto S. Accolla and Mauro Fasano
    Citation: Journal of Translational Medicine 2018 16:64
    Content type: Research Published on:

  27. Shigellosis persists as a public health problem worldwide causing ~ 165,000 deaths every year, of which ~ 55,000 are in children less than 5 years of age. No vaccine against shigellosis is currently licensed. ...

    Authors: Franklin R. Toapanta, Paula J. Bernal, Karen L. Kotloff, Myron M. Levine and Marcelo B. Sztein
    Citation: Journal of Translational Medicine 2018 16:61
    Content type: Research Published on:

  28. Th17 cells and its effective cytokine IL-17A play an important role in the pathogenesis of abnormal immune responses in psoriasis. Notch1 signaling has been implicated in Th17 cell differentiation and function...

    Authors: Lei Ma, Haibo Xue, Ruiqun Qi, Yanqin Wang and Libing Yuan
    Citation: Journal of Translational Medicine 2018 16:59
    Content type: Research Published on:

  29. An altered gut microbiota balance is involved in the pathogenesis of inflammatory bowel disease (IBD), and several probiotic strains are used as dietary supplements to improve intestinal health. We evaluated t...

    Authors: Jin-Sil Park, JeongWon Choi, Ji Ye Kwon, Kyung-Ah Jung, Chul Woo Yang, Sung-Hwan Park and Mi-La Cho
    Citation: Journal of Translational Medicine 2018 16:37
    Content type: Research Published on:

  30. During infection with human cytomegalovirus (HCMV) several viral proteins occur on cell surfaces in high quantity. We thus pursue an HLA-independent approach for immunotherapy of HCMV using chimeric antigen re...

    Authors: Julia Proff, Charlotte U. Brey, Armin Ensser, Wolfgang Holter and Manfred Lehner
    Citation: Journal of Translational Medicine 2018 16:26
    Content type: Research Published on:

  31. Cancer vaccines can effectively establish clinically relevant tumor immunity. Novel sequencing approaches rapidly identify the mutational fingerprint of tumors, thus allowing to generate personalized tumor vac...

    Authors: Katja Sonntag, Hisayoshi Hashimoto, Matthias Eyrich, Moritz Menzel, Max Schubach, Dennis Döcker, Florian Battke, Carolina Courage, Helmut Lambertz, Rupert Handgretinger, Saskia Biskup and Karin Schilbach
    Citation: Journal of Translational Medicine 2018 16:23
    Content type: Research Published on:

  32. Myeloid-derived suppressor cells (MDSCs) are a series of innate cells that play a significant role in inhibiting T cell-related responses. This heterogeneous population of immature cells is involved in tumor i...

    Authors: Weitao Zhang, Jiawei Li, Guisheng Qi, Guowei Tu, Cheng Yang and Ming Xu
    Citation: Journal of Translational Medicine 2018 16:19
    Content type: Review Published on:

  33. There is a pressing need in rheumatoid arthritis (RA) to identify patients who will not respond to first-line disease-modifying anti-rheumatic drugs (DMARD). We explored whether differences in genomic architec...

    Authors: Claudio Carini, Ewan Hunter, Aroul S. Ramadass, Jayne Green, Alexandre Akoulitchev, Iain B. McInnes and Carl S. Goodyear
    Citation: Journal of Translational Medicine 2018 16:18
    Content type: Research Published on:

  34. Genetic engineering of T-cells to express specific T cell receptors (TCR) has emerged as a novel strategy to treat various malignancies. More widespread utilization of these types of therapies has been somewha...

    Authors: Jianjian Jin, Nikolaos Gkitsas, Vicki S. Fellowes, Jiaqiang Ren, Steven A. Feldman, Christian S. Hinrichs, David F. Stroncek and Steven L. Highfill
    Citation: Journal of Translational Medicine 2018 16:13
    Content type: Research Published on:

  35. γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity. As a bridge between the innate and adaptive immune syst...

    Authors: Yijing Zhao, Chao Niu and Jiuwei Cui
    Citation: Journal of Translational Medicine 2018 16:3
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:122

  36. Cytokine disturbances have been suggested to be associated with the Chronic Fatigue Syndrome/Myalgic encephalomyelitis (CFS/ME) for decades.

    Authors: Megan E. Roerink, Hans Knoop, Ewald M. Bronkhorst, Henk A. Mouthaan, Luuk J. A. C. Hawinkels, Leo A. B. Joosten and Jos W. M. van der Meer
    Citation: Journal of Translational Medicine 2017 15:267
    Content type: Research Published on:

  37. Ulcerative colitis (UC) is a highly progressive inflammatory disease that requires the interaction of epithelial, immune, endothelial and muscle cells and fibroblasts. Previous studies suggested two inflammato...

    Authors: Henrika Jodeleit, Pia Palamides, Florian Beigel, Thomas Mueller, Eckhard Wolf, Matthias Siebeck and Roswitha Gropp
    Citation: Journal of Translational Medicine 2017 15:265
    Content type: Research Published on:

  38. Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a re...

    Authors: Vegard Bruun Wyller, Chinh Bkrong Nguyen, Judith Anita Ludviksen and Tom Eirik Mollnes
    Citation: Journal of Translational Medicine 2017 15:245
    Content type: Research Published on:

  39. Nivolumab is an anti-PD1 checkpoint inhibitor active in patients with advanced melanoma and as adjuvant therapy in high-risk metastatic melanoma patients.

    Authors: Silvana Morello, Mariaelena Capone, Claudia Sorrentino, Diana Giannarelli, Gabriele Madonna, Domenico Mallardo, Antonio M. Grimaldi, Aldo Pinto and Paolo Antonio Ascierto
    Citation: Journal of Translational Medicine 2017 15:244
    Content type: Research Published on:

  40. Understanding immune phenotypes and human gastric disease in situ requires an approach that leverages multiplexed immunohistochemistry (mIHC) with multispectral imaging to facilitate precise image analyses.

    Authors: Le Ying, Feng Yan, Qiaohong Meng, Xiangliang Yuan, Liang Yu, Bryan R. G. Williams, David W. Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Dakang Xu and Yiqun Hu
    Citation: Journal of Translational Medicine 2017 15:206
    Content type: Research Published on:

  41. The complex interactions between the immune system and tumors lead the identification of key molecules that govern these interactions: immunotherapeutics were designed to overcome the mechanisms broken by tumo...

    Authors: Paolo A. Ascierto, Bruno Daniele, Hans Hammers, Vera Hirsh, Joseph Kim, Lisa Licitra, Rita Nanda and Sandro Pignata
    Citation: Journal of Translational Medicine 2017 15:205
    Content type: Meeting report Published on:

  42. The current BCG vaccine induces only short-term protection against Mycobacterium tuberculosis (Mtb), suggesting its failure to generate long-lasting memory T cells. Previously, we have demonstrated that a self-ad...

    Authors: Pradeep K. Rai, Sathi Babu Chodisetti, Weiguang Zeng, Sajid Nadeem, Sudeep K. Maurya, Susanta Pahari, Ashok K. Janmeja, David C. Jackson and Javed N. Agrewala
    Citation: Journal of Translational Medicine 2017 15:201
    Content type: Research Published on:

  43. A small proportion of HIV-infected patients remain clinically and/or immunologically stable for years, including elite controllers (ECs) who have undetectable viremia (<50 copies/ml) and long-term nonprogresso...

    Authors: Le-Le Zhang, Zi-Ning Zhang, Xian Wu, Yong-Jun Jiang, Ya-Jing Fu and Hong Shang
    Citation: Journal of Translational Medicine 2017 15:191
    Content type: Research Published on:

  44. Our research is focused on using the vaccine draining lymph node to better understand the immune response to cancer vaccines and as a possible source of anti-cancer reagents. We evaluated vaccine draining lymp...

    Authors: Girja S. Shukla, Walter C. Olson, Stephanie C. Pero, Yu-jing Sun, Chelsea L. Carman, Craig L. Slingluff Jr. and David N. Krag
    Citation: Journal of Translational Medicine 2017 15:180
    Content type: Research Published on:

  45. The success of immunotherapeutics in oncology and the search for further improvements has prompted revisiting the use of cancer vaccines. In this context, knowledge of the immunogenic epitopes and the monitori...

    Authors: Tanja Scheikl-Gatard, Caroline Tosch, François Lemonnier and Ronald Rooke
    Citation: Journal of Translational Medicine 2017 15:154
    Content type: Research Published on:

  46. Thanks to striking progress in both the understanding of anti-tumor immune response and the characterization of several tumor associated antigens (TAA), a more rational design and more sophisticated strategies...

    Authors: Valeria Rolih, Giuseppina Barutello, Selina Iussich, Raffaella De Maria, Elena Quaglino, Paolo Buracco, Federica Cavallo and Federica Riccardo
    Citation: Journal of Translational Medicine 2017 15:151
    Content type: Review Published on:

  47. Immunotherapy consists of activating the patient’s immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have eme...

    Authors: Michele Graciotti, Cristiana Berti, Harm-Anton Klok and Lana Kandalaft
    Citation: Journal of Translational Medicine 2017 15:142
    Content type: Review Published on:

  48. Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high...

    Authors: Kevin Hollevoet and Paul J. Declerck
    Citation: Journal of Translational Medicine 2017 15:131
    Content type: Review Published on:

  49. Invariant natural killer T (iNKT) cells are a small population of lymphocytes with unique specificity for glycolipid antigens presented by non-polymorphic CD1d receptor on dendritic cells (DCs). iNKT cells pla...

    Authors: Laura Escribà-Garcia, Carmen Alvarez-Fernández, Marta Tellez-Gabriel, Jorge Sierra and Javier Briones
    Citation: Journal of Translational Medicine 2017 15:115
    Content type: Research Published on:

  50. The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the ...

    Authors: Liang Li, Mubing Duan, Weisan Chen, An Jiang, Xiaoming Li, Jun Yang and Zongfang Li
    Citation: Journal of Translational Medicine 2017 15:111
    Content type: Review Published on:
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