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Correction to: Gamma-delta (γδ) T cells: friend or foe in cancer development?

The Original Article was published on 10 January 2018

Correction to: J Transl Med (2018) 16:3

Following publication of the original article [1], the authors reported that they omitted to state that parts of Fig. 2 were adapted from Van Acker et al. [2] published by Taylor & Francis Ltd ( The authors apologise for this omission. Figure 2 and its corrected caption are given below.

Fig. 2
figure 2

(Parts of this figure are adapted from Van Acker et al.)

Antitumor and protumor functions of γδ T cells. γδ T cells have both direct and indirect antitumor effects. Direct antitumor effects are mediated by lysing the tumor through the perforin-granzyme pathway, providing an early source of the inflammatory cytokines such as IFN-γ and TNF-α, eliminating Fas+ and TRAIL-R+ tumor cells, and ADCC. The indirect antitumor role of γδ T cells is mediated by polarized γδ Tfh cells, which promote B-cell antibody secretion. Besides, γδ T cells also present antigens for αβ T cell priming, trigger dendritic cell (DC) maturation, and induce robust NK cell-mediated antitumor cytotoxicity to play indirect antitumor role. With regard to their protumor effect, γδ T cells can polarize into FOXP3+ γδ Treg cells, and γδ T17 cells. In addition, Vδ1 T cells are another subset of γδ T cells that possess protumor activity. γδ T cells are able to directly impair αβ T cells and DC antitumor immunocyte function. γδ T cells can also enhance MDSC, SPM, and neutrophil immunosuppressive functions. Together, these actions promote tumor angiogenesis, growth, proliferation, metastasis, and immune escape


  1. Zhao Y, Niu C, Cui J. Gamma-delta (γδ) T cells: friend or foe in cancer development? J Transl Med. 2018;16:3.

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  2. Van Acker HH, Anguille S, Van Tendeloo VF, Lion E. Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy. OncoImmunology. 2015;4(8):e1021538.

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Correspondence to Jiuwei Cui.

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Zhao, Y., Niu, C. & Cui, J. Correction to: Gamma-delta (γδ) T cells: friend or foe in cancer development?. J Transl Med 16, 122 (2018).

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