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Emerging Therapeutics

Section edited by Gennaro Ciliberto

© Parilov / stock.adobe.comThe Emerging Therapeutics section is dedicated to the wave of emerging therapeutics arising from the intense research efforts and therapeutic breakthroughs based on recent scientific and technological developments. 

The section is interested in original papers, reviews and perspectives on the advancements in the field, including genetic vaccines, monoclonal antibodies, CAR-Ts, gene therapy with viral vectors, clinical applications of CRISPR/CAS9 gene editing, microbiota-modulating approaches, ‘omics approaches, emerging therapeutics from the development of new technologies for drug development, and discovery of new intervention targets and the possibility for new drug combinations.

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  1. Colorectal cancer (CRC) is highly prevalent and lethal globally, and its prognosis remains unsatisfactory. Drug resistance is regarded as the main cause of treatment failure leading to tumor recurrence and met...

    Authors: Kuei-Yen Tsai, Yu-Jia Chang, Chien-Yu Huang, G. M. Shazzad Hossain Prince, Hsin-An Chen, Precious Takondwa Makondi, Ying-Rou Shen and Po-Li Wei
    Citation: Journal of Translational Medicine 2023 21:505
    Content type: Research Published on:

  2. Small cell lung cancer (SCLC) is a recalcitrant malignancy with elusive mechanism of pathogenesis and dismal prognosis. Over the past decades, platinum-based chemotherapy has been the backbone treatment for SC...

    Authors: Chenyue Zhang, Chenxing Zhang, Kai Wang and Haiyong Wang
    Citation: Journal of Translational Medicine 2023 21:468
    Content type: Review Published on:

  4. Irinotecan (CPT-11) is a classic chemotherapeutic agent that plays an important role in the clinical treatment of metastatic colon cancer and other malignant tumors. We previously designed a series of novel ir...

    Authors: Yongqi Li, Dawei Zhao, Wenqiu Zhang, Miaomiao Yang, Zhihui Wu, Weiguo Shi, Shijie Lan, Zhen Guo, Hong Yu and Di Wu
    Citation: Journal of Translational Medicine 2023 21:422
    Content type: Research Published on:

  5. Recent studies have discovered an emerging role of IL11 in various colitis-associated cancers, suggesting that IL11 mainly promotes tumor cell survival and proliferation in regulating tumorigenesis. Herein we ...

    Authors: Wenjun Xiong, Yuehong Chen, Chaoting Zhang, Jin Li, Haipeng Huang, Yu Zhu, Guangxu Deng, Junhong Cheng, Yixiong Lin, Zhimin Shi and Tingyu Mou
    Citation: Journal of Translational Medicine 2023 21:416
    Content type: Research Published on:

  7. Thyroid-associated ophthalmopathy (TAO) is the most common autoimmune inflammatory diseases of the orbit. The CD40-CD40L pathway has been regarded as a potential molecular mechanism contributing to the develop...

    Authors: Yizhi Chen, Renhong Tang, Wei Xiong, Feng Zhang, Nuo Wang, Bingyu Xie, Jiamin Cao, Zhuokun Chen and Chen Ma
    Citation: Journal of Translational Medicine 2023 21:396
    Content type: Research Published on:

  8. Bispecific antibody has garnered considerable attention in the recent years due to its impressive preliminary efficacy in hematological malignancies. For solid tumors, however, the main hindrance is the suppre...

    Authors: Po-Lin Huang, Hung-Tsai Kan, Ching-Hsuan Hsu, Hsin-Ta Hsieh, Wan-Chien Cheng, Ren-Yeong Huang and Jhong-Jhe You
    Citation: Journal of Translational Medicine 2023 21:346
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:550

  9. More than half of the colorectal cancer (CRC) patients will develop liver metastasis that underlies the cancer mortality. In the hepatic tumor microenvironment, the interplay between CRC cells and hepatic stel...

    Authors: Xueying Fan, Mingjing Meng, Baoting Li, Hui Chen, Jincheng Tan, Keyang Xu, Shilin Xiao, Hiu-Yee Kwan, Zhongqiu Liu and Tao Su
    Citation: Journal of Translational Medicine 2023 21:260
    Content type: Research Published on:

  11. Cancer associated fibroblasts (CAFs) communicate metabolically with tumor genesis and development. Rocuronium bromide (RB) is reported to exert certain inhibitory effect on tumor. Here, we investigate the role...

    Authors: Jingyi Li, Xuefeng Gu, Guoqing Wan, Yuhan Wang, Kaijie Chen, Qi Chen and Changlian Lu
    Citation: Journal of Translational Medicine 2023 21:248
    Content type: Research Published on:

  12. Endometrial cancer (EC) is one of the most common gynecological malignancies globally, and the development of innovative, effective drugs against EC remains a key issue. Phytoestrogen kaempferol exhibits anti-...

    Authors: Guan-Yu Ruan, Li-Xiang Ye, Jian-Song Lin, Hong-Yu Lin, Li-Rui Yu, Cheng-Yan Wang, Xiao-Dan Mao, Shui-Hua Zhang and Peng-Ming Sun
    Citation: Journal of Translational Medicine 2023 21:204
    Content type: Research Published on:

  14. Alterations in the MET gene, including amplifications and exon 14 skipping mutations, have been identified as actionable oncogenic alterations. However, MET fusions are rarely detected in lung cancer, and thei...

    Authors: Dantong Sun, Weizheng Wu, Li Wang, Jialin Qu, Qiman Han, Huiyun Wang, Shanai Song, Ning Liu, Yongjie Wang and Helei Hou
    Citation: Journal of Translational Medicine 2023 21:150
    Content type: Research Published on:

  15. Valtrate, a natural compound isolated from the root of Valeriana, exhibits antitumor activity in many cancers through different mechanisms. However, its efficacy for the treatment of glioblastoma (GBM), a tumor t...

    Authors: Xuemeng Liu, Yaotian Hu, Zhiyi Xue, Xun Zhang, Xiaofei Liu, Guowei Liu, Muzi Wen, Anjing Chen, Bin Huang, Xingang Li, Ning Yang and Jian Wang
    Citation: Journal of Translational Medicine 2023 21:147
    Content type: Research Published on:

  16. The incidence of bladder cancer (BCa) is approximately four times higher in men than in women. To develop effective BCa treatments, there is an urgent need to understand the differences in the BCa control mech...

    Authors: Jaekwon Seok, Hee Jeong Kwak, Yeonjoo Kwak, Moonjung Lee, Kyoung Sik Park, Aram Kim and Ssang-Goo Cho
    Citation: Journal of Translational Medicine 2023 21:129
    Content type: Research Published on:

  18. The overall survival rate of patients with advanced ovarian cancer (OC) has remained static for several decades. Advanced ovarian cancer is known for its poor prognosis due to extensive metastasis. Epigenetic ...

    Authors: Jieyu Wang, Fangfang Zhong, Jun Li, Huiran Yue, Wenzhi Li and Xin Lu
    Citation: Journal of Translational Medicine 2023 21:38
    Content type: Research Published on:

  19. NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulat...

    Authors: Siyi Lu, Zhaoyu Chen, Zhenzhen Liu and Zhentao Liu
    Citation: Journal of Translational Medicine 2023 21:31
    Content type: Review Published on:

  20. Since ancient times, plants have been an extensive reservoir of bioactive compounds with therapeutic interest for new drug development and clinical application. Cucurbitacins are a compelling example of these ...

    Authors: Carla Varela, Catarina Melim, Beatriz G. Neves, Javad Sharifi-Rad, Daniela Calina, Assem Mamurova and Célia Cabral
    Citation: Journal of Translational Medicine 2022 20:630
    Content type: Review Published on:

  21. Glioblastoma is the most lethal form of brain tumor with a recurrence rate of almost 90% and a survival time of only 15 months post-diagnosis. It is a highly heterogeneous, aggressive, and extensively studied ...

    Authors: C. Pawan K. Patro, Nupur Biswas, Sandeep C. Pingle, Feng Lin, Misa Anekoji, Lawrence D. Jones, Santosh Kesari, Feng Wang and Shashaanka Ashili
    Citation: Journal of Translational Medicine 2022 20:620
    Content type: Review Published on:

  22. Kinin B1 receptors (B1Rs) are implicated in the pathogenesis of fibrosis. This study examined the anti-fibrotic effects of B1R blockade with BI 113823 in two established mouse models of hepatic fibrosis induce...

    Authors: Dileep Reddy Rampa, Huiying Feng, Sivakumar Allur-Subramaniyan, Kwanseob Shim, Anton Pekcec, Dongwon Lee, Henri Doods and Dongmei Wu
    Citation: Journal of Translational Medicine 2022 20:590
    Content type: Research Published on:

  23. Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins and lipids o...

    Authors: Francesca Rosato, Rajeev Pasupuleti, Jana Tomisch, Ana Valeria Meléndez, Dajana Kolanovic, Olga N. Makshakova, Birgit Wiltschi and Winfried Römer
    Citation: Journal of Translational Medicine 2022 20:578
    Content type: Research Published on:

  24. Pharmacological modulation of cannabinoid 2 receptor (CB2R) is a promising therapeutic strategy for pulmonary fibrosis (PF). Thus, to develop CB2R selective ligands with new chemical space has attracted much r...

    Authors: Tao Liu, Jing Gu, Yi Yuan, Qunfang Yang, Peng-Fei Zheng, Changyu Shan, Fangqin Wang, Hongwei Li, Xiang-Qun Xie, Xiao-Hong Chen and Qin Ouyang
    Citation: Journal of Translational Medicine 2022 20:565
    Content type: Research Published on:

  26. Liver cancer is the fifth leading cause of cancer death worldwide, but early diagnosis and treatment of liver cancer remains a clinical challenge. How to screen and diagnose liver cancer early and prolong the ...

    Authors: Lihua Wang, Zheng Zhu, Qi Liang, Yecheng Tao, Gaowei Jin, Yaoyao Zhong, Jichen Dai, Ruixia Dai, Zhixiang Wang, Junbo Chen, Lingjie Zhou, Shouyu Ke, Bin Zheng, Linhua Lan, Xiaokun Lin and Tongke Chen
    Citation: Journal of Translational Medicine 2022 20:530
    Content type: Research Published on:

  27. Non-small cell lung cancer (NSCLC) is the most common lung cancer with high mortality across the world, but it is challenging to develop an effective therapy for NSCLC. Celastrol is a natural bioactive compoun...

    Authors: Zhucheng Zhao, Yanmao Wang, Yuyan Gong, Xian Wang, Luyao Zhang, Haiyang Zhao, Jifa Li, Jiandong Zhu, Xiaoying Huang, Chengguang Zhao, Lehe Yang and Liangxing Wang
    Citation: Journal of Translational Medicine 2022 20:525
    Content type: Research Published on:

  28. Pulmonary fibrosis is a chronic progressive fibrotic interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition caused by activated fibroblasts. Increasing evidence shows that m...

    Authors: Demin Cheng, Ziwei Li, Yue Wang, Haojie Xiong, Wenqing Sun, Siyun Zhou, Yi Liu and Chunhui Ni
    Citation: Journal of Translational Medicine 2022 20:523
    Content type: Research Published on:

  29. We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT...

    Authors: Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer and A. Hamid Boulares
    Citation: Journal of Translational Medicine 2022 20:521
    Content type: Research Published on:

  30. Colorectal cancer (CRC) is one of the most commonly diagnosed human malignancies. Ribosomal protein L31 (RPL31, aka eL31) is a component of the 60S large ribosomal subunit, and its expression pattern and funct...

    Authors: Gaowa Sharen, Xiongfeng Li, Jiaxin Sun, Lei Zhang, Wen Xi, Xiaodong Zhao, Fei Han, Longlong Jia, Rong A, Haidong Cheng and Mingxing Hou
    Citation: Journal of Translational Medicine 2022 20:493
    Content type: Research Published on:

  32. Pancreatic adenocarcinoma (PAAD) is one of the most common malignant tumors of the digestive tract. Pyroptosis is a newly discovered programmed cell death that highly correlated with the prognosis of tumors. H...

    Authors: Cheng Yan, Yandie Niu, Feng Li, Wei Zhao and Liukai Ma
    Citation: Journal of Translational Medicine 2022 20:455
    Content type: Research Published on:

  33. Liver hepatocellular carcinoma (LIHC) ranks sixth among the most common types of cancer with a high mortality rate. Cuproptosis is a newly discovered type of cell death in tumor, which is characterized by accu...

    Authors: Cheng Yan, Yandie Niu, Liukai Ma, Lifang Tian and Jiahao Ma
    Citation: Journal of Translational Medicine 2022 20:452
    Content type: Research Published on:

  34. Gliomas account for about 80% of all malignant brain and other central nervous system (CNS) tumors. Temozolomide (TMZ) resistance represents a major treatment hurdle. Adrenomedullin (ADM) has been reported to ...

    Authors: Zongze He, Meixiong Cheng, Junting Hu, Lingtong Liu, Ping Liu, Longyi Chen, Deqian Cao and Jian Tang
    Citation: Journal of Translational Medicine 2022 20:443
    Content type: Research Published on:

  35. Colorectal cancer (CRC) is one of the most common malignancies and the patient survival rate remains unacceptably low. The anti-programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) antibody-ba...

    Authors: Lian-sheng Cheng, Yong-feng Cheng, Wen-ting Liu, Aolin Shen, Dayan Zhang, Tingjuan Xu, Wu Yin, Min Cheng, Xiaopeng Ma, Fengrong Wang, Qun Zhao, Xiaoli Zeng, Yan Zhang and Guodong Shen
    Citation: Journal of Translational Medicine 2022 20:415
    Content type: Research Published on:

  36. Nonalcoholic steatohepatitis (NASH) occupies a substantial proportion of chronic liver disease worldwide, of which pathogenesis needs further research. Recent studies have demonstrated the significant roles of...

    Authors: Boqiang Liu, Yuanshi Tian, Jing He, Qiuxia Gu, Binghan Jin, Hao Shen, Weiqi Li, Liang Shi, Hong Yu, Ge Shan and Xiujun Cai
    Citation: Journal of Translational Medicine 2022 20:393
    Content type: Research Published on:

  38. Castration-resistant prostate cancer (CRPC) is a major cause of recurrence and mortality among prostate cancer (PCa) patients. Myeloid-derived suppressor cells (MDSCs) regulate castration resistance in PCa. Pr...

    Authors: Feng Gao, Qiaoping Xu, Zhe Tang, Nan Zhang, Yasheng Huang, Zhongyi Li, Yuliang Dai, Qiqi Yu and Jingyu Zhu
    Citation: Journal of Translational Medicine 2022 20:346
    Content type: Research Published on:

  39. Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. Efficacy of the bromodomain 4 (BRD4) inhibitor JQ1 has been reported for the treatment of various human cancers, but ...

    Authors: Yingxin Pang, Gaigai Bai, Jing Zhao, Xuan Wei, Rui Li, Jie Li, Shunxue Hu, Lu Peng, Peishu Liu and Hongluan Mao
    Citation: Journal of Translational Medicine 2022 20:336
    Content type: Research Published on:

  40. Effective treatment is needed for advanced, inoperable, or chemotherapy-resistant cervical cancer patients. Immunotherapy has become a new treatment modality for cervical cancer patients, and there is an urgen...

    Authors: Siyang Zhang, Han Wang, Jiao Liu, Tao Tao, Zhi Zeng and Min Wang
    Citation: Journal of Translational Medicine 2022 20:334
    Content type: Research Published on:

  41. Our previous study has identified a novel circRNA (circDIDO1) that is down-regulated in gastric cancer (GC) and significantly inhibits GC progression. The purpose of this study is to identify the molecular mec...

    Authors: Zhen Guo, Yu Zhang, Wenrong Xu, Xu Zhang and Jiajia Jiang
    Citation: Journal of Translational Medicine 2022 20:326
    Content type: Research Published on:

  42. Enolase is an essential enzyme in the process of glycolysis and has been implicated in cancer progression. Though dysregulation of ENOs has been reported in multiple cancers, their prognostic value and specifi...

    Authors: Zhengnan Huang, Yilin Yan, Tengjiao Wang, Zeyi Wang, Jinming Cai, Xiangqian Cao, Chenkai Yang, Fang Zhang, Gang Wu and Bing Shen
    Citation: Journal of Translational Medicine 2022 20:315
    Content type: Research Published on:

  43. Patients with triple-negative breast cancer (TNBC) are better responders to neoadjuvant chemotherapy; however, they are poor in the durability of response with decreased overall and progression-free survival.

    Authors: Zhao-ying Yang, Cheng-wei Jiang, Wen-long Zhang and Guang Sun
    Citation: Journal of Translational Medicine 2022 20:276
    Content type: Research Published on:

  44. Ovarian cancer (OC) is a major threat to women’s health. Mesenchymal stem cells (MSCs) are key regulators in cellular communication by secreting extracellular vesicles (EVs) that are involved in OC. This study...

    Authors: Xiaoying Wang, Lili Jiang and Qifang Liu
    Citation: Journal of Translational Medicine 2022 20:258
    Content type: Research Published on:

  45. Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are...

    Authors: Halema Al-Farsi, Iman Al-Azwani, Joel A. Malek, Lotfi Chouchane, Arash Rafii and Najeeb M. Halabi
    Citation: Journal of Translational Medicine 2022 20:244
    Content type: Research Published on:

  46. The Great Debate session at the 2021 Melanoma Bridge virtual congress (December 2–4) featured counterpoint views from experts on seven important issues in melanoma. The debates considered the use of adoptive c...

    Authors: Paolo A. Ascierto, Allison Betof Warner, Christian Blank, Corrado Caracò, Sandra Demaria, Jeffrey E. Gershenwald, Nikhil I. Khushalani, Georgina V. Long, Jason J. Luke, Janice M. Mehnert, Caroline Robert, Piotr Rutkowski, Hussein A. Tawbi, Iman Osman and Igor Puzanov
    Citation: Journal of Translational Medicine 2022 20:200
    Content type: Meeting report Published on:

  48. In this study we aimed to investigate signaling pathways that drive therapy resistance in esophageal adenocarcinoma (EAC). Paraffin-embedded material was analyzed in two patient cohorts: (i) 236 EAC patients w...

    Authors: A. Creemers, A. P. van der Zalm, A. van de Stolpe, L. Holtzer, M. Stoffels, G. K. J. Hooijer, E. A. Ebbing, H. van Ooijen, A. G. C. van Brussel, E. M. G. Aussems-Custers, M. I. van Berge Henegouwen, M. C. C. M. Hulshof, J. J. G. H. M. Bergman, S. L. Meijer, M. F. Bijlsma and H. W. M. van Laarhoven
    Citation: Journal of Translational Medicine 2022 20:183
    Content type: Research Published on:

  49. Exosomes are microvesicles secreted by cells. They contain a variety of bioactive substances with important roles in intercellular communication. Circular RNA (circRNA), a type of nucleic acid molecule found i...

    Authors: Dong Ye, Mengdan Gong, Yongqin Deng, Shuai Fang, Yujie Cao, Yizhen Xiang and Zhisen Shen
    Citation: Journal of Translational Medicine 2022 20:161
    Content type: Review Published on:

  50. JAK1 and JAK2 have been implicated in fibrosis and cancer as a fibroblast-related marker; however, their role in liver fibrosis has not been elucidated. Here, we aim to determine the effect and underlying mech...

    Authors: Zhenghui Song, Xinhui Liu, Wan Zhang, Yue Luo, Hua Xiao, Yun Liu, Guanqi Dai, Jian Hong and Aimin Li
    Citation: Journal of Translational Medicine 2022 20:157
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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