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Disease Biomarkers

Section edited by Xiangdong Wang and Hao Fang

The Disease Biomarkers section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Featured articles

Microfluidic devices for neutrophil chemotaxis studies

Review | Wenjie Zhao et al

Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model

Research | Han Wang et al

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Research | Michael A. Kiebish et al

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  1. Golgi phosphoprotein 3 (GOLPH3) has been validated as a potent oncogene involved in the progression of many types of solid tumors, and its overexpression is associated with poor clinical outcome in many cancer...

    Authors: Zaozao Wang, Beihai Jiang, Lei Chen, Jiabo Di, Ming Cui, Maoxing Liu, Yiyuan Ma, Hong Yang, Jiadi Xing, Chenghai Zhang, Zhendan Yao, Nan Zhang, Bin Dong, Jiafu Ji and Xiangqian Su
    Citation: Journal of Translational Medicine 2014 12:15
  2. Nasopharyngeal carcinoma (NPC) is a solid tumor of the head and neck. Multimodal therapy is highly effective when NPC is detected early. However, due to the location of the tumor and the absence of clinical si...

    Authors: Jordan L Plieskatt, Gabriel Rinaldi, Yanjung Feng, Paul H Levine, Samantha Easley, Elizabeth Martinez, Salman Hashmi, Nader Sadeghi, Paul J Brindley, Jeffrey M Bethony and Jason P Mulvenna
    Citation: Journal of Translational Medicine 2014 12:3
  3. Hypermethylation in the promoter regions is associated with the suppression of gene expression and has been considered a potential molecular marker for several tumor types, including head and neck squamous cel...

    Authors: Marianna Marconato Rettori, Ana Carolina de Carvalho, Ana Luiza Bomfim Longo, Cleyton Zanardo de Oliveira, Luiz Paulo Kowalski, André Lopes Carvalho and André Luiz Vettore
    Citation: Journal of Translational Medicine 2013 11:316
  4. We have previously demonstrated an aberrant overexpression of the microtubule-associated protein TPX2 in colon cancer using a genome-wide gene expression profiling analysis. Here, we aim to investigate its exp...

    Authors: Ping Wei, Nu Zhang, Ye Xu, Xinxiang Li, Debing Shi, Yuwei Wang, Dawei Li and Sanjun Cai
    Citation: Journal of Translational Medicine 2013 11:313
  5. Early disease detection with a minimally invasive screening test will significantly increase effectiveness and decrease the cost of treatment. Here we propose a framework of a novel approach – Universal Screen...

    Authors: Kira S Sheinerman, Vladimir G Tsivinsky and Samuil R Umansky
    Citation: Journal of Translational Medicine 2013 11:304
  6. INI1 (Integrase interactor 1), also known as SMARCB1, is the most studied subunit of chromatin remodelling complexes. Its role in colorectal tumorigenesis is not known.

    Authors: Massimo Pancione, Andrea Remo, Caterina Zanella, Lina Sabatino, Arturo Di Blasi, Carmelo Laudanna, Laura Astati, Michele Rocco, Delfina Bifano, Paolo Piacentini, Laura Pavan, Alberto Purgato, Filippo Greco, Alberto Talamini, Andrea Bonetti, Michele Ceccarelli…
    Citation: Journal of Translational Medicine 2013 11:297
  7. The ability to forecast whether a wound will heal after closure without further debridement(s), would provide substantial benefits to patients with severe extremity trauma.

    Authors: Brett A Chromy, Angela Eldridge, Jonathan A Forsberg, Trevor S Brown, Benjamin C Kirkup, Crystal Jaing, Nicholas A Be, Eric Elster and Paul A Luciw
    Citation: Journal of Translational Medicine 2013 11:281
  8. Steadily high melanoma mortality rates urge for the availability of novel biomarkers with a more personalized ability to predict melanoma clinical outcomes. Germline risk variants are promising candidates for ...

    Authors: Justin Rendleman, Shulian Shang, Christine Dominianni, Jerry F Shields, Patrick Scanlon, Christina Adaniel, Alexis Desrichard, Michelle Ma, Richard Shapiro, Russell Berman, Anna Pavlick, David Polsky, Yongzhao Shao, Iman Osman and Tomas Kirchhoff
    Citation: Journal of Translational Medicine 2013 11:279
  9. Paxillin (PXN) has been found to be aberrantly regulated in various malignancies and involved in tumor growth and invasion. The clinicopathological and prognostic significance of PXN in gastric cancer is still...

    Authors: Dong-liang Chen, Zhi-qiang Wang, Chao Ren, Zhao-lei Zeng, De-shen Wang, Hui-yan Luo, Feng Wang, Miao-zhen Qiu, Long Bai, Dong-sheng Zhang, Feng-hua Wang, Yu-hong Li and Rui-hua Xu
    Citation: Journal of Translational Medicine 2013 11:277
  10. Increasing evidence has suggested that dysregulation of certain microRNAs (miRNAs) may contribute to human disease including carcinogenesis and tumor metastasis in human. miR-124-3p is down-regulated in variou...

    Authors: Xianglai Xu, Shiqi Li, Yiwei Lin, Hong Chen, Zhenghui Hu, Yeqing Mao, Xin Xu, Jian Wu, Yi Zhu, Xiangyi Zheng, Jindan Luo and Liping Xie
    Citation: Journal of Translational Medicine 2013 11:276
  11. Colorectal cancer (CRC) is the most common digestive system malignancy. The molecular events involved in the development and progression of CRC remain unclear. Recently, more and more evidences have showed tha...

    Authors: Limin Long, Guoqing Huang, Hongyi Zhu, Yonghong Guo, Youshuo Liu and Jirong Huo
    Citation: Journal of Translational Medicine 2013 11:275
  12. The La-related protein 1 (LARP1) has been found to be a RNA binding protein and was related to spermatogenesis, embryogenesis and cell-cycle progression. The aim of this study was to investigate the prognostic...

    Authors: Chan Xie, Li Huang, Shibin Xie, Dongying Xie, Genlin Zhang, Peipei Wang, Liang Peng and Zhiliang Gao
    Citation: Journal of Translational Medicine 2013 11:272
  13. Alcohol consumption is a major cause of liver disease in humans. The use and monitoring of biomarkers associated with early, pre-clinical stages of alcohol-induced liver disease (pre-ALD) could facilitate diag...

    Authors: Heng-Hong Li, Kathryn Doiron, Andrew D Patterson, Frank J Gonzalez and Albert J Fornace Jr
    Citation: Journal of Translational Medicine 2013 11:266
  14. Atherosclerosis is the main cause of morbidity and mortality in Western countries and carotid plaque rupture is associated to acute events and responsible of 15-20% of all ischemic strokes. Several proteomics ...

    Authors: Silvia Rocchiccioli, Gualtiero Pelosi, Silvia Rosini, Michele Marconi, Federica Viglione, Lorenzo Citti, Mauro Ferrari, Maria Giovanna Trivella and Antonella Cecchettini
    Citation: Journal of Translational Medicine 2013 11:260
  15. Matrix metalloproteinases can promote invasion and metastasis, which are very frequent in renal cell carcinoma even at the time of diagnosis. Knowing the reversion-inducing cysteine-rich protein with Kazal mot...

    Authors: Anja Rabien, Carsten Stephan, Ergin Kilic, Wilko Weichert, Glen Kristiansen, Kurt Miller, Klaus Jung and Andreas Erbersdobler
    Citation: Journal of Translational Medicine 2013 11:258
  16. Although the potential of biomarkers to aid in early detection of colorectal cancer (CRC) is recognized and numerous biomarker candidates have been reported in the literature, to date only few molecular marker...

    Authors: Stine Buch Thorsen, Martin Lundberg, Andrea Villablanca, Sarah Louise T Christensen, Kirstine Christensen Belling, Birgitte Sander Nielsen, Mick Knowles, Nick Gee, Hans Jørgen Nielsen, Nils Brünner, Ib Jarle Christensen, Simon Fredriksson, Jan Stenvang and Erika Assarsson
    Citation: Journal of Translational Medicine 2013 11:253
  17. Chronic Fatigue Syndrome (CFS) is a severe, systemic illness characterized by persistent, debilitating and medically unexplained fatigue. The etiology and pathophysiology of CFS remains obscure, and diagnosis ...

    Authors: Federica Ciregia, Laura Giusti, Ylenia Da Valle, Elena Donadio, Arianna Consensi, Camillo Giacomelli, Francesca Sernissi, Pietro Scarpellini, Fabrizio Maggi, Antonio Lucacchini and Laura Bazzichi
    Citation: Journal of Translational Medicine 2013 11:243
  18. The incidence and mortality of hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) is higher in African Americans (AA) than other racial/ethnic groups in the U.S., but the reasons for this disparity...

    Authors: Simon T Dillon, Manoj K Bhasin, Xiaoxing Feng, David W Koh and Sayed S Daoud
    Citation: Journal of Translational Medicine 2013 11:239
  19. Due to known limitations of liver biopsy, reliable non-invasive serum biomarkers for chronic liver diseases are needed. We performed serum peptidomics for such investigation in compensated chronic hepatitis B ...

    Authors: Ming-Yi Xu, Xiao-Fang Jia, Ying Qu, Rui-Dan Zheng, Zheng-Hong Yuan, Hong-Lei Weng, Steven Dooley, Xing-Peng Wang, Li-Jun Zhang and Lun-Gen Lu
    Citation: Journal of Translational Medicine 2013 11:234
  20. Long non-coding RNAs (lncRNAs) are prevalently transcribed in the genome yet their potential roles in human cancers are not well understood. The aim of the present study was to determine the lncRNA expression ...

    Authors: Haojun Song, Weiliang Sun, Guoliang Ye, Xiaoyun Ding, Zhong Liu, Sijie Zhang, Tian Xia, Bingxiu Xiao, Yang Xi and Junming Guo
    Citation: Journal of Translational Medicine 2013 11:225
  21. The control of Mycobacterium tuberculosis (Mtb) infection begins with the recognition of mycobacterial structural components by toll like receptors (TLRs) and other pattern recognition receptors. Our objective wa...

    Authors: Diana Torres-García, Alfredo Cruz-Lagunas, Ma Cecilia García-Sancho Figueroa, Rosario Fernández-Plata, Renata Baez-Saldaña, Criselda Mendoza-Milla, Rodrigo Barquera, Aida Carrera-Eusebio, Salomón Ramírez-Bravo, Lizeth Campos, Javier Angeles, Gilberto Vargas-Alarcón, Julio Granados, Radha Gopal, Shabaana A Khader, Edmond J Yunis…
    Citation: Journal of Translational Medicine 2013 11:220
  22. Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue, resulting in increased fragility and susceptibility to fracture. Osteoporotic fractures are a significant cause of mo...

    Authors: Gillian Wheater, Mohsen Elshahaly, Stephen P Tuck, Harish K Datta and Jacob M van Laar
    Citation: Journal of Translational Medicine 2013 11:201
  23. Increasing evidence indicates that deregulation of microRNAs (miRNAs) is involved in tumorigenesis. Downregulation of microRNA-503 has been observed in various types of diseases, including cancer. However, the...

    Authors: Fenqiang Xiao, Wu zhang, Liming Chen, Fei Chen, Haiyang Xie, Chunyang Xing, Xiaobo Yu, Songming Ding, Kangjie Chen, Haijun Guo, Jun Cheng, Shusen Zheng and Lin Zhou
    Citation: Journal of Translational Medicine 2013 11:195
  24. After hematopoietic stem cell transplantation (HSCT) T- and B-cell reconstitution from primary lymphoid organs are a prerequisite for an effective early lymphocyte reconstitution and a long-term survival for a...

    Authors: Angela Mensen, Christoph Ochs, Andrea Stroux, Friedrich Wittenbecher, Martin Szyska, Luisa Imberti, Simon Fillatreau, Lutz Uharek, Renate Arnold, Bernd Dörken, Andreas Thiel, Carmen Scheibenbogen and Il-Kang Na
    Citation: Journal of Translational Medicine 2013 11:188
  25. Hypoxia inducible factor-1 alpha (HIF-1α), induced by tumor hypoxia, regulates tumor cell metabolism and metastasis by up-regulation of c-Met, carbonic anhydrase 9 (CA9) and glucose transporter 1 (GLUT1). The ...

    Authors: Bo Wook Kim, Hanbyoul Cho, Joon-Yong Chung, Catherine Conway, Kris Ylaya, Jae-Hoon Kim and Stephen M Hewitt
    Citation: Journal of Translational Medicine 2013 11:185
  26. The aim of the present study was to investigate within ovarian carcinoma and normal ovarian biopsies the gene expression of multiple secretoglobin family members relative to mammaglobin B, which we previously ...

    Authors: Eliana Bignotti, Renata A Tassi, Stefano Calza, Antonella Ravaggi, Elisa Rossi, Carla Donzelli, Paola Todeschini, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Mario Carnazza, Francesco Quadraro, Germana Tognon, Enrico Sartori, Sergio Pecorelli, Dana M Roque…
    Citation: Journal of Translational Medicine 2013 11:162
  27. The cell division cycle 20 homolog (CDC20) is an essential cofactor of the anaphase-promoting complex (APC/C). CDC20 overexpression has been detected in many types of human cancers; however, its clinical role ...

    Authors: Wen-jing Wu, Kai-shun Hu, De-shen Wang, Zhao-lei Zeng, Dong-sheng Zhang, Dong-liang Chen, Long Bai and Rui-hua Xu
    Citation: Journal of Translational Medicine 2013 11:142
  28. The aim of this study was to analyze the expression of protein tyrosine kinase 6 (PTK6) in nasopharyngeal carcinoma (NPC) samples, and to identify whether PTK6 can serve as a biomarker for the diagnosis and pr...

    Authors: Li-na Liu, Pei-yu Huang, Zhi-rui Lin, Li-juan Hu, Jian-zhong Liang, Man-zhi Li, Lin-quan Tang, Mu-sheng Zeng, Qian Zhong and Bo-hang Zeng
    Citation: Journal of Translational Medicine 2013 11:140
  29. Gadd45a is a member of the Gadd45 family of genes that are known stress sensors. Gadd45a has been shown to serve as an effector in oncogenic stress in breast carcinogenesis in murine models. The present study ...

    Authors: Jennifer S Tront, Alliric Willis, Yajue Huang, Barbara Hoffman and Dan A Liebermann
    Citation: Journal of Translational Medicine 2013 11:131
  30. T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) are circular DNA segments generated in T and B cells during their maturation in the thymus and bone marrow. Th...

    Authors: Federico Serana, Marco Chiarini, Cinzia Zanotti, Alessandra Sottini, Diego Bertoli, Andrea Bosio, Luigi Caimi and Luisa Imberti
    Citation: Journal of Translational Medicine 2013 11:119
  31. Although the prognostic roles of β-catenin expression in non-small cell lung cancer (NSCLC) have been reported in several immunohistochemical (IHC) studies, the results were not consistent because some studies...

    Authors: Xi-Qing Li, Xing-Long Yang, Gong Zhang, Si-Pei Wu, Xu-Bing Deng, Sheng-Jun Xiao, Qiu-Zhen Liu, Kai-Tai Yao and Guang-Hui Xiao
    Citation: Journal of Translational Medicine 2013 11:114
  32. Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the adult mammalian brain, but exerts physiologic effects other than that on neurotransmitter in non-neuronal peripheral tissues and or...

    Authors: Xiaoxue Zhang, Rong Zhang, Yuanjie Zheng, Jianfei Shen, Dakai Xiao, Jin Li, Xiaoshun Shi, Liyan Huang, Hailing Tang, Jun Liu, Jianxing He and Haibo Zhang
    Citation: Journal of Translational Medicine 2013 11:102
  33. The bone morphogenetic family proteins (BMP) are phytogenetically conserved proteins, which are essential for embryonic development. The key regulatory subunit, the bone morphogenetic protein 4 (BMP4), is over...

    Authors: Zhaoshi Bao, Chuanbao Zhang, Wei Yan, Yanwei Liu, Mingyang Li, Wei Zhang and Tao Jiang
    Citation: Journal of Translational Medicine 2013 11:100
  34. Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by persistent fatigue that is not alleviated by rest. The lack of a clearly identified underlying mechanism has hindered the development ...

    Authors: Elizabeth Ann Stringer, Katharine Susanne Baker, Ian R Carroll, Jose G Montoya, Lily Chu, Holden T Maecker and Jarred W Younger
    Citation: Journal of Translational Medicine 2013 11:93
  35. Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is...

    Authors: Elena Dementyeva, Fedor Kryukov, Lenka Kubiczkova, Pavel Nemec, Sabina Sevcikova, Ivana Ihnatova, Jiri Jarkovsky, Jiri Minarik, Zdena Stefanikova, Petr Kuglik and Roman Hajek
    Citation: Journal of Translational Medicine 2013 11:77
  36. The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in multiple myeloma (MM), a blood cancer associated with uncontrolled proliferation of bone marrow plasma cells. This study aimed to dev...

    Authors: Congfen Li, Chikara Takahashi, Liangxuan Zhang, Mahrukh Huseni, Basha Stankovich, Haider Mashhedi, Joanna Lee, Dorothy French, Jeff Eastham Anderson, Doris Kim, Kathy Howell, Matthew J Brauer, Marcin Kowanetz, Yibing Yan, Eric Humke, Allen Ebens…
    Citation: Journal of Translational Medicine 2013 11:76
  37. Treatment with ipilimumab, a fully human anti-CTLA-4 antibody approved for the treatment of advanced melanoma, is associated with some immune-related adverse events (irAEs) such as colitis (gastrointestinal ir...

    Authors: Vafa Shahabi, David Berman, Scott D Chasalow, Lisu Wang, Zenta Tsuchihashi, Beihong Hu, Lisa Panting, Maria Jure-Kunkel and Rui-Ru Ji
    Citation: Journal of Translational Medicine 2013 11:75
  38. Personalized chemotherapy based on molecular biomarkers can maximize anticancer efficiency. We aim to investigate predictive biomarkers capable of predicting response to irinotecan-based treatment in gastric c...

    Authors: Jie Shen, Jia Wei, Hao Wang, Guofeng Yue, Lixia Yu, Yang Yang, Li Xie, Zhengyun Zou, Xiaoping Qian, Yitao Ding, Wenxian Guan and Baorui Liu
    Citation: Journal of Translational Medicine 2013 11:73
  39. Several peripheral proteins that might be useful for detecting the presence of ectopic pregnancy (EP) have been evaluated, but none have been proven entirely useful in the clinic. We investigated the presence ...

    Authors: Shien Zou, Xin Li, Yi Feng, Shan Sun, Jin Li, Emil Egecioglu, Håkan Billig and Ruijin Shao
    Citation: Journal of Translational Medicine 2013 11:44
  40. It is well known that the disease progression in cystic fibrosis (CF) patients may be diverse in subjects with identical mutation in CFTR gene. It is quite possible that such heterogeneity is associated with TNF-

    Authors: Galina Shmarina, Alexander Pukhalsky, Nika Petrova, Ekaterina Zakharova, Lucine Avakian, Nikolai Kapranov and Vladimir Alioshkin
    Citation: Journal of Translational Medicine 2013 11:19

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