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Cell, Tissue and Gene Therapy

Section edited by David Stroncek

This section aims to improve communication between basic and clinical research related to cell, tissue and gene therapies. Effective clinical therapies require efficient translation of research between the bench and bedside to allow the discovery, development, scale up, and production of cells, tissues and vectors. These therapies are being used to treat patients with a range of diseases including cancer, cardiovascular diseases, autoimmune disorders.

Studies considered for publication include those regarding the nature of cells, tissues and vectors used in clinical therapies; methods to collect, isolate and modify cells; and novel reagents, equipment, and instruments used in production. The section also welcomes research into the application of clinical therapies; factors that effect the safety and efficacy; in particular the potency, stability and purity of cells or tissue; and issues related to the safety of cell and tissue donors.

Featured articles

Phase I and registry study of autologous bone marrow concentrate evaluated in PDE5 inhibitor refractory erectile dysfunction

Research | Mark Bieri et al


Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients​​​​​​​

Review | Christopher J. Rogers et al


Allo-priming as a universal anti-viral vaccine: protecting elderly from current COVID-19 and any future unknown viral outbreak

Review |  Michael Har-Noy & Reuven Or 

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  1. Liver transplantation is the definitive treatment for many end-stage liver diseases. However, the life-long immunosuppression needed to prevent graft rejection causes clinically significant side effects. Cellu...

    Authors: Felix C Popp, Barbara Fillenberg, Elke Eggenhofer, Philipp Renner, Johannes Dillmann, Volker Benseler, Andreas A Schnitzbauer, James Hutchinson, Robert Deans, Deborah Ladenheim, Cheryl A Graveen, Florian Zeman, Michael Koller, Martin J Hoogduijn, Edward K Geissler, Hans J Schlitt…
    Citation: Journal of Translational Medicine 2011 9:124
  2. This study tested the hypothesis that autologous transplantation of adipose-derived mesenchymal stem cells (ADMSCs) can effectively attenuate acute pulmonary ischemia-reperfusion (IR) injury.

    Authors: Cheuk-Kwan Sun, Chia-Hung Yen, Yu-Chun Lin, Tzu-Hsien Tsai, Li-Teh Chang, Ying-Hsien Kao, Sarah Chua, Morgan Fu, Sheung-Fat Ko, Steve Leu and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2011 9:118
  3. Lipid metabolites and cytokines, including chemokines and growth factors, are the key regulators of immune cell function and differentiation, and thus, dysregulation of these regulators is associated with vari...

    Authors: Hyun Ok Kim, Han-Soo Kim, Jong-Chan Youn, Eui-Cheol Shin and Sungha Park
    Citation: Journal of Translational Medicine 2011 9:113
  4. The field of cellular therapy of cancer is moving quickly and the issues involved with its advancement are complex and wide ranging. The growing clinical applications and success of adoptive cellular therapy o...

    Authors: Cornelis JM Melief, John J O'Shea and David F Stroncek
    Citation: Journal of Translational Medicine 2011 9:107
  5. In our recent study, Periostin was up-regulated in prostate cancer(PCa) compared with benign prostate hyperplasia (BPH) by proteomics analysis of prostate biopsies. We investigated the effect of sliencing Peri...

    Authors: Chuanyu Sun, Xiaojun Zhao, Ke Xu, Jian Gong, Weiwei Liu, Weihong Ding, Yuancheng Gou, Guowei Xia and Qiang Ding
    Citation: Journal of Translational Medicine 2011 9:99
  6. The F11 Receptor (F11R; aka JAM-A, JAM-1) is a cell adhesion protein present constitutively on the membrane surface of circulating platelets and within tight junctions of endothelial cells (ECs). Previous repo...

    Authors: Bani M Azari, Jonathan D Marmur, Moro O Salifu, Yigal H Ehrlich, Elizabeth Kornecki and Anna Babinska
    Citation: Journal of Translational Medicine 2011 9:98
  7. Hemoglobin E/β-thalassemia is particularly common in Southeast Asia and has variable symptoms ranging from mild to severe anemia. Previous investigations demonstrated the remarkable symptoms of β-thalassemia i...

    Authors: Saranyoo Ponnikorn, Tasanee Panichakul, Kitima Sresanga, Chokdee Wongborisuth, Sittiruk Roytrakul, Suradej Hongeng and Sumalee Tungpradabkul
    Citation: Journal of Translational Medicine 2011 9:96
  8. Reactive oxygen species are important mediators exerting toxic effects on various organs during ischemia-reperfusion (IR) injury. We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect th...

    Authors: Yen-Ta Chen, Cheuk-Kwan Sun, Yu-Chun Lin, Li-Teh Chang, Yung-Lung Chen, Tzu-Hsien Tsai, Sheng-Ying Chung, Sarah Chua, Ying-Hsien Kao, Chia-Hung Yen, Pei-Lin Shao, Kuan-Cheng Chang, Steve Leu and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2011 9:51
  9. Emerging evidence suggests that cancer stem cells account for the initiation and progression of cancer. While many types of cancer stem cells with specific markers have been isolated and identified, a variety ...

    Authors: Hai-Guang Liu, Chong Chen, Han Yang, Yi-Fei Pan and Xiao-Hua Zhang
    Citation: Journal of Translational Medicine 2011 9:50
  10. siRNA technology is a promising tool for gene therapy of vascular disease. Due to the multitude of reagents and cell types, RNAi experiment optimization can be time-consuming. In this study adherent cell cytom...

    Authors: Christoph S Nabzdyk, Maggie Chun, Leena Pradhan and Frank W LoGerfo
    Citation: Journal of Translational Medicine 2011 9:48
  11. Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion injury in animal models. However, as hESC-MSCs are not...

    Authors: Tian Sheng Chen, Fatih Arslan, Yijun Yin, Soon Sim Tan, Ruenn Chai Lai, Andre Boon Hwa Choo, Jayanthi Padmanabhan, Chuen Neng Lee, Dominique PV de Kleijn and Sai Kiang Lim
    Citation: Journal of Translational Medicine 2011 9:47
  12. Polyethyleneimine (PEI), which can interact with negatively charged DNA through electrostatic interaction to form nanocomplexes, has been widely attempted to use as a gene delivery system. However, PEI has som...

    Authors: Zhizhong Xu, Guobo Shen, Xiangying Xia, Xinyu Zhao, Peng Zhang, Huanhuan Wu, Qingfa Guo, Zhiyong Qian, Yuquan Wei and Shufang Liang
    Citation: Journal of Translational Medicine 2011 9:46
  13. Gene therapy is a promising therapeutic approach for cancer. Targeted expression of desired therapeutic proteins within the tumor is the best approach to reduce toxicity and improve survival. This study is to ...

    Authors: Yu Xu, Jinxuan Hou, Zhengchun Liu, Haijun Yu, Wenjie Sun, Jie Xiong, Zhengkai Liao, Fuxiang Zhou, Conghua Xie and Yunfeng Zhou
    Citation: Journal of Translational Medicine 2011 9:39
  14. The aim of the present study was to analyze the expression of Cyclin-dependent kinase 4 (CDK4) in lung cancer and its correlation with clinicopathologic features. Furthermore, the involvement of CDK4-mediated cel...

    Authors: Aibing Wu, Bin Wu, Jinsong Guo, Weiren Luo, Dong Wu, Huiling Yang, Yan Zhen, Xiaoli Yu, Hao Wang, Ying Zhou, Zhen Liu, Weiyi Fang and Zhixiong Yang
    Citation: Journal of Translational Medicine 2011 9:38
  15. Stem cell therapy holds the promise to treat degenerative diseases, cancer and repair of damaged tissues for which there are currently no or limited therapeutic options. The potential of stem cell therapies ha...

    Authors: Carla A Herberts, Marcel SG Kwa and Harm PH Hermsen
    Citation: Journal of Translational Medicine 2011 9:29
  16. After publication of our article [1], we realized the need for posting a correction note in order to prevent i) overinterpretation of some results by the readers and ii) concerns about potentially unintended misg...

    Authors: Michaela Muth, Kais Hussein, Christoph Jacobi, Hans Kreipe and Oliver Bock
    Citation: Journal of Translational Medicine 2011 9:24

    The original article was published in Journal of Translational Medicine 2010 8:33

  17. We challenge the hypothesis of enhanced myocardial reperfusion after implanting a left ventricular assist device together with bone marrow mononuclear stem cells in patients with end-stage ischemic cardiomyopa...

    Authors: Kyriakos Anastasiadis, Polychronis Antonitsis, Helena Argiriadou, Georgios Koliakos, Argyrios Doumas, Andre Khayat, Christos Papakonstantinou and Stephen Westaby
    Citation: Journal of Translational Medicine 2011 9:12
  18. We investigated whether myocardium-derived conditioned medium (MDCM) is effective in preserving left ventricular (LV) function in a rat acute myocardial infarction (AMI) model.

    Authors: Steve Leu, Ying-Hsien Kao, Cheuk-Kwan Sun, Yu-Chun Lin, Tzu-Hsien Tsai, Li-Teh Chang, Sarah Chua, Kuo-Ho Yeh, Chiung-Jen Wu, Morgan Fu and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2011 9:11
  19. Mesenchymal stem cells derived from adipose tissue (ADSC) are multipotent stem cells, originated from the vascular-stromal compartment of fat tissue. ADSC are used as an alternative cell source for many differ...

    Authors: Anastasia Efimenko, Ekaterina Starostina, Natalia Kalinina and Alexandra Stolzing
    Citation: Journal of Translational Medicine 2011 9:10
  20. Adenoid cystic carcinoma is one of the most common types of salivary gland cancers. The poor long-term prognosis for patients with adenoid cystic carcinoma is mainly due to local recurrence and distant metasta...

    Authors: Qin Xu, Xiuming Liu, Wantao Chen and Zhiyuan Zhang
    Citation: Journal of Translational Medicine 2010 8:136
  21. Apoptosis is an early event involved in cardiomyopathy associated with diabetes mellitus. Toll-like receptor (TLR) signaling triggers cell apoptosis through multiple mechanisms. Up-regulation of TLR4 expressio...

    Authors: Yuwei Zhang, Tianqing Peng, Huaqing Zhu, Xiufen Zheng, Xusheng Zhang, Nan Jiang, Xiaoshu Cheng, Xiaoyan Lai, Aminah Shunnar, Manpreet Singh, Neil Riordan, Vladimir Bogin, Nanwei Tong and Wei-Ping Min
    Citation: Journal of Translational Medicine 2010 8:133
  22. Growth hormone (GH) is an essential regulator of intrahepatic lipid metabolism by activating multiple complex hepatic signaling cascades. Here, we examined whether chronic exogenous GH administration (via gene...

    Authors: Ying Qin and Ya-ping Tian
    Citation: Journal of Translational Medicine 2010 8:120
  23. Culturing otospheres from dissociated organ of Corti is an appropriate starting point aiming at the development of cell therapy for hair cell loss. Although guinea pigs have been widely used as an excellent ex...

    Authors: Jeanne Oiticica, Luiz Carlos M Barboza-Junior, Ana Carla Batissoco, Karina Lezirovitz, Regina C Mingroni-Netto, Luciana A Haddad and Ricardo F Bento
    Citation: Journal of Translational Medicine 2010 8:119
  24. Recent years have seen a growing interest in insulin-like growth factor 1 receptor (IGF1R) in medical oncology. Interesting data have been reported also on IGF1r in gastrointestinal stromal tumors (GISTs) espe...

    Authors: Maria A Pantaleo, Annalisa Astolfi, Margherita Nannini and Guido Biasco
    Citation: Journal of Translational Medicine 2010 8:117
  25. The ability to expand virus- or tumor-specific T cells without damaging their functional capabilities is critical for success adoptive transfer immunotherapy of patients with opportunistic infection or tumor. ...

    Authors: Yixin Li and Roger J Kurlander
    Citation: Journal of Translational Medicine 2010 8:104
  26. We investigated whether early combined autologous adipose-derived mesenchymal stem cell (ADMSC) and sildenafil therapy offers an additive benefit in preserving heart function in rat dilated cardiomyopathy (DCM).

    Authors: Yu-Chun Lin, Steve Leu, Cheuk-Kwan Sun, Chia-Hung Yen, Ying-Hsien Kao, Li-Teh Chang, Tzu-Hsien Tsai, Sarah Chua, Morgan Fu, Sheung-Fat Ko, Chiung-Jen Wu, Fan-Yen Lee and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2010 8:88
  27. The current paradigm for cord blood transplantation is that HLA matching and immune suppression are strictly required to prevent graft versus host disease (GVHD). Immunological arguments and historical example...

    Authors: Wan-Zhang Yang, Yun Zhang, Fang Wu, Wei-Ping Min, Boris Minev, Min Zhang, Xiao-Ling Luo, Famela Ramos, Thomas E Ichim, Neil H Riordan and Xiang Hu
    Citation: Journal of Translational Medicine 2010 8:75
  28. The therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) on brain infarction area (BIA) and neurological status in a rat model of acute ischemic stroke (IS) was investigated.

    Authors: Steve Leu, Yu-Chun Lin, Chun-Man Yuen, Chia-Hung Yen, Ying-Hsien Kao, Cheuk-Kwan Sun and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2010 8:63
  29. This manuscript reports the production and preclinical studies to examine the tolerance and efficacy of an autologous cellular gel-matrix integrated implant system (IIS) aimed to treat full-thickness skin lesi...

    Authors: Caroline R Weinstein-Oppenheimer, Alexis R Aceituno, Donald I Brown, Cristian Acevedo, Ricardo Ceriani, Miguel A Fuentes, Fernando Albornoz, Carlos F Henríquez-Roldán, Patricio Morales, Claudio Maclean, Sergio M Tapia and Manuel E Young
    Citation: Journal of Translational Medicine 2010 8:59
  30. While adjuvant immunotherapy with Bacille Calmette Guérin (BCG) is effective in non-muscle-invasive bladder cancer (BC), adverse events (AEs) are considerable. Monocyte-derived activated killer cells (MAK) are...

    Authors: Maximilian Burger, Nicolas Thiounn, Stefan Denzinger, Jozsef Kondas, Gerard Benoit, Manuel S Chapado, Fernando J Jimenz-Cruz, Laszlo Kisbenedek, Zoltán Szabo, Domján Zsolt, Marc O Grimm, Imre Romics, Joachim W Thüroff, Tamas Kiss, Bertrand Tombal, Manfred Wirth…
    Citation: Journal of Translational Medicine 2010 8:54
  31. Antigen processing by dendritic cells (DC) exposed to specific stimuli has been well characterized in biological studies. Nonetheless, the question of whether autologous whole tumor lysates (as used in clinica...

    Authors: Laura Fiammenghi, Valentina Ancarani, Tilman Rosales, Jay R Knutson, Massimiliano Petrini, Anna Maria Granato, Elena Pancisi, Laura Ridolfi, Ruggero Ridolfi, Angela Riccobon and Paolo Neyroz
    Citation: Journal of Translational Medicine 2010 8:52
  32. MicroRNAs are highly conserved, noncoding RNAs involved in post-transcriptional gene silencing. They have been shown to participate in a wide range of biological processes, including myogenesis and muscle rege...

    Authors: Stefano Gambardella, Fabrizio Rinaldi, Saverio M Lepore, Antonella Viola, Emanuele Loro, Corrado Angelini, Lodovica Vergani, Giuseppe Novelli and Annalisa Botta
    Citation: Journal of Translational Medicine 2010 8:48
  33. NSC-741909 is a novel anticancer agent that can effectively suppress the growth of several cell lines derived from lung, colon, breast, ovarian, and kidney cancers. We recently showed that NSC-741909-induced a...

    Authors: Xiaoli Wei, Wei Guo, Shuhong Wu, Li Wang, Peng Huang, Jinsong Liu and Bingliang Fang
    Citation: Journal of Translational Medicine 2010 8:37
  34. The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of circulating progenitor cells using G-CSF has resulted in pr...

    Authors: Nina A Mikirova, James A Jackson, Ron Hunninghake, Julian Kenyon, Kyle WH Chan, Cathy A Swindlehurst, Boris Minev, Amit N Patel, Michael P Murphy, Leonard Smith, Famela Ramos, Thomas E Ichim and Neil H Riordan
    Citation: Journal of Translational Medicine 2010 8:34
  35. In damaged organs tissue repair and replacement of cells by connective tissue provokes a response of fibroblasts to cellular stress factors such as hypoxia.

    Authors: Michaela Muth, Katharina Theophile, Kais Hussein, Christoph Jacobi, Hans Kreipe and Oliver Bock
    Citation: Journal of Translational Medicine 2010 8:33
  36. Human stem cells from adult sources have been shown to contribute to the regeneration of muscle, liver, heart, and vasculature. The mechanisms by which this is accomplished are, however, still not well underst...

    Authors: Claus S Sondergaard, David A Hess, Dustin J Maxwell, Carla Weinheimer, Ivana Rosová, Michael H Creer, David Piwnica-Worms, Attila Kovacs, Lene Pedersen and Jan A Nolta
    Citation: Journal of Translational Medicine 2010 8:24
  37. The medical use of low level laser (LLL) irradiation has been occurring for decades, primarily in the area of tissue healing and inflammatory conditions. Despite little mechanistic knowledge, the concept of a ...

    Authors: Feng Lin, Steven F Josephs, Doru T Alexandrescu, Famela Ramos, Vladimir Bogin, Vincent Gammill, Constantin A Dasanu, Rosalia De Necochea-Campion, Amit N Patel, Ewa Carrier and David R Koos
    Citation: Journal of Translational Medicine 2010 8:16

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