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Cancer Microenvironment

Section edited by Davide Bedognetti

© © nopparit / Getty Images / iStock

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles


microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ

Research | Zhenming Jiang et al


Tumor microenvironment differences between primary tumor and brain metastases

Review | Bernardo Cacho-Díaz et al


Identification of key genes controlling breast cancer stem cell characteristics via stemness indices analysis

Research | Jianying Pei et al

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  1. As a surface glycoprotein, CD147 is capable of stimulating the production of matrix metalloproteinases (MMPs) from neighboring fibroblasts. The aim of the present study is to explore the role of soluble CD147 ...

    Authors: Jiao Wu, Zhi-Wei Hao, You-Xu Zhao, Xiang-Min Yang, Hao Tang, Xin Zhang, Fei Song, Xiu-Xuan Sun, Bin Wang, Gang Nan, Zhi-Nan Chen and Huijie Bian
    Citation: Journal of Translational Medicine 2014 12:190
  2. Disulfiram (DS), an anti-alcoholism drug, demonstrates strong antitumor activity in a copper (Cu)-dependent manner. This study investigates the cytotoxicity of DS/Cu complex in lymphoid malignant cell lines in vi...

    Authors: Jie Zha, Feili Chen, Huijuan Dong, Pengcheng Shi, Yao Yao, Yanyan Zhang, Rongwei Li, Shiyun Wang, Peng Li, Weiguang Wang and Bing Xu
    Citation: Journal of Translational Medicine 2014 12:163
  3. Tumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology...

    Authors: Peter D Caie, Arran K Turnbull, Susan M Farrington, Anca Oniscu and David J Harrison
    Citation: Journal of Translational Medicine 2014 12:156
  4. Nuclear factor-κB (NF-κB) induces a variety of biological processes through transcriptional gene control whose products are components in various signaling pathways. MicroRNAs are a small endogenous non-coding...

    Authors: Jian Zhang, Haidong Wu, Pu Li, Yanzheng Zhao, Min Liu and Hua Tang
    Citation: Journal of Translational Medicine 2014 12:155
  5. The goal of this study was to investigate the expression of sarcosine metabolism-related proteins, namely glycine N-methyltransferase (GNMT), sarcosine dehydrogenase (SARDH), and l-pipecolic acid oxidase (PIPOX),...

    Authors: Ja Kyung Yoon, Do Hee Kim and Ja Seung Koo
    Citation: Journal of Translational Medicine 2014 12:149
  6. Anti-angiogenic therapy inhibits tumor growth and is considered as a potential clinical therapy for malignant glioma. However, inevitable recurrences and unexpected tumor resistance, particularly increased inv...

    Authors: Cheng-Shi Xu, Ze-Fen Wang, Li-Ming Dai, Sheng-Hua Chu, Ling-Ling Gong, Ming-Huan Yang and Zhi-Qiang Li
    Citation: Journal of Translational Medicine 2014 12:148
  7. The use of autoantibodies for the early detection of breast cancer has generated much interest as antibodies can be readily assayed in serum when antigen levels are low. Ideally, diagnostic autoantibodies woul...

    Authors: Jianning Mao, Jon Ladd, Ekram Gad, Lauren Rastetter, Melissa M Johnson, Edmond Marzbani, Jennifer S Childs, Hailing Lu, Yushe Dang, Elizabeth Broussard, Sasha E Stanton, Sam M Hanash and Mary L Disis
    Citation: Journal of Translational Medicine 2014 12:121
  8. Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite current therapeutic advances, still confer a poor outcome to half of the patients. As other solid tumors, STSs exhibit high glucose consumpt...

    Authors: Céline Pinheiro, Valter Penna, Filipa Morais-Santos, Lucas F Abrahão-Machado, Guilherme Ribeiro, Emílio C Curcelli, Marcus V Olivieri, Sandra Morini, Isabel Valença, Daniela Ribeiro, Fernando C Schmitt, Rui M Reis and Fátima Baltazar
    Citation: Journal of Translational Medicine 2014 12:118
  9. We studied whether thymidylate synthase (TS) genotype has an independent prognostic/predictive impact on a European population of advanced non-small cell lung cancer (NSCLC) patients receiving pemetrexed.

    Authors: Estefanía Arévalo, Eduardo Castañón, Inés López, Josefa Salgado, Víctor Collado, Marta Santisteban, María Rodríguez-Ruiz, Patricia Martín, Leire Zubiri, Ana Patiño-García, Christian Rolfo and Ignacio Gil-Bazo
    Citation: Journal of Translational Medicine 2014 12:98
  10. Reliable prognostic markers based on biopsy specimens of colorectal cancer (CRC) are currently missing. We hypothesize that assessment of T-cell infiltration in biopsies of CRC may predict patient survival and...

    Authors: Viktor H Koelzer, Alessandro Lugli, Heather Dawson, Marion Hädrich, Martin D Berger, Markus Borner, Makhmudbek Mallaev, José A Galván, Jennifer Amsler, Beat Schnüriger, Inti Zlobec and Daniel Inderbitzin
    Citation: Journal of Translational Medicine 2014 12:81
  11. Transforming growth factor β (TGF-β) signaling functions as a suppressor or a promoter in tumor development, depending on the tumor stage and type. However, the role of TGF-β signaling in nonfunctioning pituit...

    Authors: Li Zhenye, Li Chuzhong, Wu Youtu, Lan Xiaolei, Cao Lei, Hong Lichuan, Wang Hongyun, Wu Yonggang, Wang Fei and Zhang Yazhuo
    Citation: Journal of Translational Medicine 2014 12:71
  12. The cross talk between the stroma and cancer cells plays a major role in phenotypic modulation. During peritoneal carcinomatosis ovarian cancer cells interact with mesenchymal stem cells (MSC) resulting in inc...

    Authors: Raphael Lis, Cyril Touboul, Najeeb M Halabi, Abishek Sainath Madduri, Denis Querleu, Jason Mezey, Joel A Malek, Karsten Suhre and Arash Rafii
    Citation: Journal of Translational Medicine 2014 12:59
  13. Recently, involvement of the chemokine/receptor system CCL20/CCR6 in colorectal cancer (CRC) progression was shown. Here, we analyzed the functional interaction of miRNA-518-5p (miR-518a-5p) with CCR6 and its ...

    Authors: Claudia Rubie, Bianca Kruse, Vilma Oliveira Frick, Kathrin Kölsch, Pirus Ghadjar, Mathias Wagner, Friedrich Grässer, Stefan Wagenpfeil and Mathias Glanemann
    Citation: Journal of Translational Medicine 2014 12:48
  14. Stents are recommended in patients with dysphagia caused by esophageal stricture, but an ideal stent does not currently exist. Thus, studies on new esophageal stents are necessary, and suitable animal models a...

    Authors: Jin Huang, Jinquan Shuang, Guanyin Xiong, Xiang Wang, Yin Zhang, Xiaowei Tang, Zhining Fan, Yingzhou Shen, Hanming Song and Zhi Liu
    Citation: Journal of Translational Medicine 2014 12:40
  15. miR-200b has been reported to be a tumor suppressor and a promising therapeutic target in cancer. miR-200b has been associated with epithelial-mesenchymal transition and chemo-resistance in cancer. The aim of ...

    Authors: Feng Ye, Hailin Tang, Qing Liu, Xinhua Xie, Minqing Wu, Xiaoping Liu, Bo Chen and Xiaoming Xie
    Citation: Journal of Translational Medicine 2014 12:17
  16. Estrogen receptor-alpha36 (ER-α36) is a new isoform of estrogen receptors without transcriptional activation domains of the classical ER-α(ER − α66). ER-α36 is mainly located in cytoplasm and plasma membrane. ...

    Authors: Yu Gu, Tianxiang Chen, Elena López, Weizhu Wu, Xiangdong Wang, Jiang Cao and Lisong Teng
    Citation: Journal of Translational Medicine 2014 12:16
  17. The interaction between tumor cells and inflammatory cells has not been systematically investigated in esophageal squamous cell carcinoma (ESCC). The main aims of the study were to investigate the clinical sig...

    Authors: Jianbo Wang, Yibin Jia, Nana Wang, Xiaomei Zhang, Bingxu Tan, Guangyu Zhang and Yufeng Cheng
    Citation: Journal of Translational Medicine 2014 12:7
  18. The role of exosomes in the pathogenesis and metastatic spread of cancer remains to be fully elucidated. Recent studies support the hypothesis that the release of exosomes from cells modifies local extracellul...

    Authors: Miharu Kobayashi, Carlos Salomon, Jorge Tapia, Sebastian E Illanes, Murray D Mitchell and Gregory E Rice
    Citation: Journal of Translational Medicine 2014 12:4
  19. XB130 has been reported to be expressed by various types of cells such as thyroid cancer and esophageal cancer cells, and it promotes the proliferation and invasion of thyroid cancer cells. Our previous study ...

    Authors: Min Shi, Dayong Zheng, Li Sun, Lin Wang, Li Lin, Yajun Wu, Minyu Zhou, Wenjun Liao, Yulin Liao, Qiang Zuo and Wangjun Liao
    Citation: Journal of Translational Medicine 2014 12:1
  20. CD34+ progenitor cells comprise both hematopoietic and endothelial progenitor cells. Recent studies suggest that circulating endothelial progenitor cells are recruited into the angiogenic vascular system of sever...

    Authors: Barbara Vizio, Fiorella Biasi, Tiziana Scirelli, Anna Novarino, Adriana Prati, Libero Ciuffreda, Giuseppe Montrucchio, Giuseppe Poli and Graziella Bellone
    Citation: Journal of Translational Medicine 2013 11:314
  21. Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human cancers and is known to inhibit Ras/Raf/MEK/ERK signaling. By suppressing the activation of the NF...

    Authors: Eva Karamitopoulou, Inti Zlobec, Beat Gloor, Agathi Kondi-Pafiti, Alessandro Lugli and Aurel Perren
    Citation: Journal of Translational Medicine 2013 11:311
  22. Conformal intensity-modulated radiation therapy (IMRT) involves irradiation of large volume of normal tissue with low and medium doses, biological relevance of which is not clear yet. Serum proteome features w...

    Authors: Piotr Widłak, Monika Pietrowska, Joanna Polańska, Tomasz Rutkowski, Karol Jelonek, Magdalena Kalinowska-Herok, Agnieszka Gdowicz-Kłosok, Andrzej Wygoda, Rafał Tarnawski and Krzysztof Składowski
    Citation: Journal of Translational Medicine 2013 11:299
  23. Bone marrow stromal cells (BMSCs) are multipotent cells that support angiogenesis, wound healing, and immunomodulation. In the hematopoietic niche, they nurture hematopoietic cells, leukemia, tumors and metast...

    Authors: Sara Civini, Ping Jin, Jiaqiang Ren, Marianna Sabatino, Luciano Castiello, Jianjian Jin, Huan Wang, Yuanlong Zhao, Francesco Marincola and David Stroncek
    Citation: Journal of Translational Medicine 2013 11:298
  24. Obesity is a well established risk factor of colorectal cancer (CRC), but how body size influences risk of colorectal cancer defined by key molecular alterations remains unclear. In this study, we investigated...

    Authors: Jenny Brändstedt, Sakarias Wangefjord, Signe Borgquist, Björn Nodin, Jakob Eberhard, Jonas Manjer and Karin Jirström
    Citation: Journal of Translational Medicine 2013 11:293
  25. Cadherin 12 (CDH12), which encodes a type II classical cadherin from the cadherin superfamily, may mediate calcium-dependent cell adhesion. It has been demonstrated that CDH12 could play an important role in t...

    Authors: Jingkun Zhao, Pu Li, Hao Feng, Puxiongzhi Wang, Yaping Zong, Junjun Ma, Zhuo Zhang, Xuehua Chen, Minhua Zheng, Zhenggang Zhu and Aiguo Lu
    Citation: Journal of Translational Medicine 2013 11:288
  26. In recent years an increasing number of publications have emphasized the growing importance of hydrogen ion dynamics in modern cancer research, from etiopathogenesis and treatment. A proton [H+]-related mechanism...

    Authors: Salvador Harguindey, Jose Luis Arranz, Julian David Polo Orozco, Cyril Rauch, Stefano Fais, Rosa Angela Cardone and Stephan J Reshkin
    Citation: Journal of Translational Medicine 2013 11:282
  27. Residual tumor progression after insufficient radiofrequency ablation (RFA) has been recently reported. However, whether epithelial-mesenchymal transition (EMT), which is a key process that drives cancer metas...

    Authors: Shuying Dong, Jian Kong, Fandong Kong, Jinge Kong, Jun Gao, Shan Ke, Shaohong Wang, Xuemei Ding, Wenbing Sun and Lemin Zheng
    Citation: Journal of Translational Medicine 2013 11:273
  28. Transglutaminase-4 (TGase-4), also known as the Prostate Transglutaminase, is an enzyme found to be expressed predominately in the prostate gland. The protein has been recently reported to influence the migrat...

    Authors: Wen G Jiang, Lin Ye, Andrew J Sanders, Fiona Ruge, Howard G Kynaston, Richard J Ablin and Malcolm D Mason
    Citation: Journal of Translational Medicine 2013 11:269
  29. Dinaciclib, a small-molecule, cyclin-dependent kinase inhibitor, inhibits cell cycle progression and proliferation in various tumor cell lines in vitro. We conducted an open-label, dose-escalation study to det...

    Authors: John J Nemunaitis, Karen A Small, Paul Kirschmeier, Da Zhang, Yali Zhu, Ying-Ming Jou, Paul Statkevich, Siu-Long Yao and Rajat Bannerji
    Citation: Journal of Translational Medicine 2013 11:259
  30. Up to 40% of patients initially diagnosed with clinically-confined renal cell carcinoma (RCC) and who undergo curative surgery will nevertheless relapse with metastatic disease (mRCC) associated with poor long...

    Authors: Lee Campbell, Ghaith Al-Jayyoussi, Robert Gutteridge, Nigel Gumbleton, Rosie Griffiths, Simon Gumbleton, Mathew W Smith, David FR Griffiths and Mark Gumbleton
    Citation: Journal of Translational Medicine 2013 11:255
  31. The chemokine CXCL12 and its receptor CXCR4 play a major role in tumor invasion, proliferation and metastasis in different malignant diseases, including esophageal carcinoma, amongst others. CXCR7 was recently...

    Authors: Michael Tachezy, Hilke Zander, Florian Gebauer, Katharina von Loga, Klaus Pantel, Jakob R Izbicki and Maximilian Bockhorn
    Citation: Journal of Translational Medicine 2013 11:238
  32. Oct4 is a major transcription factor related to stem cell self-renewal and differentiation. To fulfill its functions, it must be able to enter the nucleus and remain there to affect transcription. KPNA2, a mem...

    Authors: Xiao-Lei Li, Lan-Ling Jia, Mu-Mu Shi, Xin Li, Zhong-Hua Li, Hui-Feng Li, En-Hua Wang and Xin-Shan Jia
    Citation: Journal of Translational Medicine 2013 11:232
  33. Special AT rich sequence binding protein 1 (SATB1) plays a crucial role in the biology of various types of human cancer. However, the role of SATB1 in human nasopharyngeal carcinoma (NPC) remains unknown. In t...

    Authors: Zhihua Shen, Yumei Zeng, Junli Guo, Yanxia Wu, Xiaofan Jiang, Ranran Ding, Changli Wu, Rujia Li, Botao Luo, Chao Zeng, Hanguo Jiang and Wei Jie
    Citation: Journal of Translational Medicine 2013 11:217
  34. Recent studies have indicated that the expression of endothelin A receptor (ETAR) and chemokine receptor 4 (CXCR4) could be used as an indicator of the metastatic potential of nasopharyngeal carcinoma (NPC). T...

    Authors: Dong-Hua Luo, Qiu-Yan Chen, Huai Liu, Li-Hua Xu, Hui-Zhong Zhang, Lu Zhang, Lin-Quan Tang, Hao-Yuan Mo, Pei-Yu Huang, Xiang Guo and Hai-Qiang Mai
    Citation: Journal of Translational Medicine 2013 11:203
  35. Chronic inflammation has been recognized to foster tumour development. Whether chemotherapy can be used to neutralize chronic inflammation is unclear.

    Authors: Andreas Carus, Howard Gurney, Val Gebski, Paul Harnett, Rina Hui, Richard Kefford, Nicholas Wilcken, Morten Ladekarl, Hans von der Maase and Frede Donskov
    Citation: Journal of Translational Medicine 2013 11:189
  36. Array-CGH represents a comprehensive tool to discover genomic disease alterations that could potentially be applied to body fluids. In this report, we aimed at applying array-CGH to urinary samples to characte...

    Authors: Virginia López, Pilar González-Peramato, Javier Suela, Alvaro Serrano, Ferrán Algaba, Juan C Cigudosa, August Vidal, Joaquim Bellmunt, Oscar Heredero and Marta Sánchez-Carbayo
    Citation: Journal of Translational Medicine 2013 11:182
  37. Estrogens were recently demonstrated to be synthesized in non-small cell lung carcinomas (NSCLCs) via aromatase activity and aromatase inhibitor (AI) did suppressed estrogen receptor (ER) positive NSCLC growth. H...

    Authors: Mohit K Verma, Yasuhiro Miki, Keiko Abe, Takashi Suzuki, Hiromichi Niikawa, Satoshi Suzuki, Takashi Kondo and Hironobu Sasano
    Citation: Journal of Translational Medicine 2013 11:167
  38. The epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) play pivotal roles in metastasis of epithelial cancers. The distinction between them has shed new light on the mole...

    Authors: Songming Ding, Wu Zhang, Zhiyuan Xu, Chunyang Xing, Haiyang Xie, Haijun Guo, Kanjie Chen, Penghong Song, Yu Gu, Fengqiang Xiao, Lin Zhou and Shusen Zheng
    Citation: Journal of Translational Medicine 2013 11:164
  39. Given the complexity of tumor microenvironment, no single marker from cancer cells could adequately predict the clinical outcomes of gastric cancer (GC). The objective of this study was to evaluate the prognos...

    Authors: Chun-Wei Peng, Lin-Wei Wang, Min Fang, Gui-Fang Yang, Yan Li and Dai-Wen Pang
    Citation: Journal of Translational Medicine 2013 11:153
  40. Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic know...

    Authors: Vincent Lavoué, Aurélie Thédrez, Jean Levêque, Fabrice Foucher, Sébastien Henno, Vincent Jauffret, Marc-Antoine Belaud-Rotureau, Veronique Catros and Florian Cabillic
    Citation: Journal of Translational Medicine 2013 11:147
  41. Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems.

    Authors: Maria Libera Ascierto, Michael O Idowu, Yingdong Zhao, Hanif Khalak, Kyle K Payne, Xiang-Yang Wang, Catherine I Dumur, Davide Bedognetti, Sara Tomei, Paolo A Ascierto, Anil Shanker, Harry D Bear, Ena Wang, Francesco M Marincola, Andrea De Maria and Masoud H Manjili
    Citation: Journal of Translational Medicine 2013 11:145
  42. Human papillomavirus type 16 (HPV 16) E2 protein is a multifunctional DNA-binding protein. HPV 16 E2 regulates many biological responses, including DNA replication, gene expression, and apoptosis. The purpose ...

    Authors: Ling-juan Gao, Ping-qing Gu, Wei Zhao, Wen-yan Ding, Xue-qing Zhao, Shu-yu Guo and Tian-ying Zhong
    Citation: Journal of Translational Medicine 2013 11:118
  43. Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as the global chromatin organizer to regulate chromatin structure and gene expression gene expression. SATB1 has been shown...

    Authors: Lijun Mao, Chunhua Yang, Junqi Wang, Wang Li, Rumin Wen, Jiacun Chen and Junnian Zheng
    Citation: Journal of Translational Medicine 2013 11:111
  44. Studies of primary patient tumor xenografts grown in immunodeficient mice have shown that these tumors histologically and genetically closely resemble the original tumors. These patient xenograft models are be...

    Authors: Bonnie L Hylander, Natalie Punt, Haikuo Tang, Joanna Hillman, Mary Vaughan, Wiam Bshara, Rose Pitoniak and Elizabeth A Repasky
    Citation: Journal of Translational Medicine 2013 11:110
  45. Interleukin (IL)-6 (mainly of tumor origin) activates glutathione (GSH) release from hepatocytes and its interorgan transport to B16-F10 melanoma metastatic foci. We studied if this capacity to overproduce IL-...

    Authors: Soraya L Valles, María Benlloch, María L Rodriguez, Salvador Mena, José A Pellicer, Miguel Asensi, Elena Obrador and José M Estrela
    Citation: Journal of Translational Medicine 2013 11:72

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