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Cancer microenvironment

Section edited by Davide Bedognetti

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles

Anovel non-hodgkin lymphoma murine model closer to the standard clinical scenario A novel non-Hodgkin lymphoma murine model closer to the standard clinical scenario
Thais Bascuas, et al


Impact of agin on host immune response and survival in melanomaImpact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts
Sarah A. Weiss, et al


Differential tumour infiltration by T-Cells characterises intrinsic molecular subtypes in breast cancerDifferential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer
M. Miyan, J, et al

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  1. Cancer invasion results from constant interactions between cancer cells and their microenvironment. Major components of the cancer microenvironment are stromal cells, infiltrating inflammatory cells, collagens...

    Authors: Chun-Wei Peng, Xiu-Li Liu, Xiong Liu and Yan Li

    Citation: Journal of Translational Medicine 2010 8:101

    Content type: Research

    Published on:

  2. Esophageal adenocarcinomas (EACs) arise due to gastroesophageal reflux, with Barrett's esophagus (BE) regarded as precancerous lesion. Matrix metalloproteinases (MMPs) might play a role during the multistep ca...

    Authors: Martin Grimm, Maria Lazariotou, Stefan Kircher, Luisa Stuermer, Christoph Reiber, Andreas Höfelmayr, Stefan Gattenlöhner, Christoph Otto, Christoph T Germer and Burkhard HA von Rahden

    Citation: Journal of Translational Medicine 2010 8:99

    Content type: Research

    Published on:

  3. Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation. The aim of this study was to examine the association between Oct4 and Sox2 expression levels with bo...

    Authors: Nan Ge, Huan-Xin Lin, Xiang-Sheng Xiao, Ling Guo, Hui-Min Xu, Xin Wang, Ting Jin, Xiu-Yu Cai, Yi Liang, Wei-Han Hu and Tiebang Kang

    Citation: Journal of Translational Medicine 2010 8:94

    Content type: Research

    Published on:

  4. Esophageal squamous cell carcinomas (ESCC) are usually asymptomatic and go undetected until they are incurable. Cytological screening is one strategy to detect ESCC at an early stage and has shown promise in p...

    Authors: Sumana Mukherjee, Mark J Roth, Sanford M Dawsey, Wusheng Yan, Jaime Rodriguez-Canales, Heidi S Erickson, Nan Hu, Alisa M Goldstein, Philip R Taylor, Annely M Richardson, Michael A Tangrea, Rodrigo F Chuaqui and Michael R Emmert-Buck

    Citation: Journal of Translational Medicine 2010 8:91

    Content type: Research

    Published on:

  5. Helicobacter pylori (H. pylori) infection is associated with chronic gastritis, peptic ulceration and gastric carcinoma. Protease-activated receptor-2 (PAR-2), which is activated by trypsin, induced the activatio...

    Authors: Joo Weon Lim and Hyeyoung Kim

    Citation: Journal of Translational Medicine 2010 8:85

    Content type: Research

    Published on:

  6. This study represents the first attempt to perform a profiling analysis of the intergenerational differences in the microRNAs (miRNAs) of primary cutaneous melanocytic neoplasms in young adult and older age gr...

    Authors: Drazen M Jukic, Uma NM Rao, Lori Kelly, Jihad S Skaf, Laura M Drogowski, John M Kirkwood and Monica C Panelli

    Citation: Journal of Translational Medicine 2010 8:27

    Content type: Research

    Published on:

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