McGlynn KA, Petrick JL, London WT. Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability. Clin Liver Dis. 2015;19:223–38.
Article
PubMed
PubMed Central
Google Scholar
Li Y, Zhang Z, Shi J, Jin L, Wang L, Xu D, Wang FS. Risk factors for naturally-occurring early-onset hepatocellular carcinoma in patients with HBV-associated liver cirrhosis in China. Int J Clin Exp Med. 2015;8:1205–12.
CAS
PubMed
PubMed Central
Google Scholar
Zhu M, Guo J, Li W, Xia H, Lu Y, Dong X, Chen Y, Xie X, Fu S, Li M. HBx induced AFP receptor expressed to activate PI3 K/AKT signal to promote expression of Src in liver cells and hepatoma cells. BMC Cancer. 2015;15:362.
Article
PubMed
PubMed Central
Google Scholar
Lee YH, Yun Y. HBx protein of hepatitis B virus activates Jak1-STAT signaling. J Biol Chem. 1998;273:25510–5.
Article
CAS
PubMed
Google Scholar
Lee YI, Kang-Park S, Do SI, Lee YI. The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem. 2001;276:16969–77.
Article
CAS
PubMed
Google Scholar
Ringelhan M, O’Connor T, Protzer U, Heikenwalder M. The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets. J Pathol. 2015;235:355–67.
Article
CAS
PubMed
Google Scholar
Ambros V. The functions of animal microRNAs. Nature. 2004;431:350–5.
Article
CAS
PubMed
Google Scholar
Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell. 2005;122:6–7.
Article
CAS
PubMed
Google Scholar
Zhang B, Pan X, Cobb GP, Anderson TA. microRNAs as oncogenes and tumor suppressors. Dev Biol. 2007;302:1–12.
Article
CAS
PubMed
Google Scholar
Zhou J, Yu L, Gao X, Hu J, Wang J, Dai Z, Wang JF, Zhang Z, Lu S, Huang X, et al. Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol. 2011;29:4781–8.
Article
CAS
PubMed
Google Scholar
Fornari F, Gramantieri L, Giovannini C, Veronese A, Ferracin M, Sabbioni S, Calin GA, Grazi GL, Croce CM, Tavolari S, et al. MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res. 2009;69:5761–7.
Article
CAS
PubMed
Google Scholar
Zhao WY, Wang DD, Song MQ, Yang L, Ye J, Chen LB. Role of microRNA-223 and its target gene oncogene c-myc in hepatocellular carcinoma pathogenesis. Zhonghua Gan Zang Bing Za Zhi. 2011;19:114–7.
CAS
PubMed
Google Scholar
Wang Y, Lu Y, Toh ST, Sung WK, Tan P, Chow P, Chung AY, Jooi LL, Lee CG. Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3. J Hepatol. 2010;53:57–66.
Article
CAS
PubMed
Google Scholar
Wu XJ, Li Y, Liu D, Zhao LD, Bai B, Xue MH. miR-27a as an oncogenic microRNA of hepatitis B virus—related hepatocellular carcinoma. Asian Pac J Cancer Prev. 2013;14:885–9.
Article
PubMed
Google Scholar
Wei X, Xiang T, Ren G, Tan C, Liu R, Xu X, Wu Z. miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A. Cell Signal. 2013;25:439–46.
Article
CAS
PubMed
Google Scholar
Feng Y, Liu J, Kang Y, He Y, Liang B, Yang P, Yu Z. miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer. J Exp Clin Cancer Res. 2014;33:67.
Article
PubMed
PubMed Central
Google Scholar
Liu Y, Lou G, Wu W, Shi Y, Zheng M, Chen Z. Interferon-alpha sensitizes HBx-expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx-mediated NF-kappaB activation. Virol J. 2013;10:168.
Article
PubMed
PubMed Central
Google Scholar
Wu Y, Zhang W, Yang Y, Yu B, Huang A. Identification of a novel negative regulatory element on the hepatitis B virus S-(+)-strand. Acta Biochim Biophys Sin (Shanghai). 2009;41:873–82.
Article
CAS
Google Scholar
Tarocchi M, Polvani S, Marroncini G, Galli A. Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis. World J Gastroenterol. 2014;20:11630–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhu R, Mok MT, Kang W, Lau SS, Yip WK, Chen Y, Lai PB, Wong VW, To KF, Sung JJ, et al. Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis. J Pathol. 2015;237(1):38–49.
Article
CAS
PubMed
Google Scholar
Hammond SM. An overview of microRNAs. Adv Drug Deliv Rev. 2015;87:3–14.
Article
CAS
PubMed
Google Scholar
Liu WH, Yeh SH, Chen PJ. Role of microRNAs in hepatitis B virus replication and pathogenesis. Biochim Biophys Acta. 2011;1809:678–85.
Article
CAS
PubMed
Google Scholar
Milella M, Falcone I, Conciatori F, Incani UC, Curatolo AD, Inzerilli N, Nuzzo CM, Vaccaro V, Vari S, Cognetti F, Ciuffreda L. PTEN: multiple functions in human malignant tumors. Front Oncol. 2015;5:24.
Article
PubMed
PubMed Central
Google Scholar
Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C, Eng C. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies. Hum Mol Genet. 1999;8:185–93.
Article
CAS
PubMed
Google Scholar
Jia Z, Wang K, Zhang A, Wang G, Kang C, Han L, Pu P. miR-19a and miR-19b overexpression in gliomas. Pathol Oncol Res. 2013;19:847–53.
Article
CAS
PubMed
Google Scholar
Li X, Xie W, Xie C, Huang C, Zhu J, Liang Z, Deng F, Zhu M, Zhu W, Wu R, et al. Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation. Phytother Res. 2014;28:1553–60.
Article
CAS
PubMed
Google Scholar
Liu M, Liu J, Wang L, Wu H, Zhou C, Zhu H, Xu N, Xie Y. Association of serum microRNA expression in hepatocellular carcinomas treated with transarterial chemoembolization and patient survival. PLoS One. 2014;9:e109347.
Article
PubMed
PubMed Central
Google Scholar
Zhang Y, Guo X, Li Z, Li B, Li Z, Li R, Guo Q, Xiong L, Yu L, Zhao J, Lin N. A systematic investigation based on microRNA-mediated gene regulatory network reveals that dysregulation of microRNA-19a/Cyclin D1 axis confers an oncogenic potential and a worse prognosis in human hepatocellular carcinoma. RNA Biol. 2015;12(6):643–57.
Article
PubMed
Google Scholar
Saitta C, Tripodi G, Barbera A, Bertuccio A, Smedile A, Ciancio A, Raffa G, Sangiovanni A, Navarra G, Raimondo G, Pollicino T. Hepatitis B virus (HBV) DNA integration in patients with occult HBV infection and hepatocellular carcinoma. Liver Int. 2015;35(10):2311–7.
Article
CAS
PubMed
Google Scholar
Zhao X, Liu M, Li D. Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis. Mol Cell Biochem. 2015;400:1–7.
Article
CAS
PubMed
Google Scholar
Xing TJ, Jiang DF, Huang JX, Xu ZL. Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease. Genet Mol Res. 2014;13:7912–8.
Article
CAS
PubMed
Google Scholar
Peng F, Xiao X, Jiang Y, Luo K, Tian Y, Peng M, Zhang M, Xu Y, Gong G. HBx down-regulated Gld2 plays a critical role in HBV-related dysregulation of miR-122. PLoS One. 2014;9:e92998.
Article
PubMed
PubMed Central
Google Scholar
Dang CV. MYC on the path to cancer. Cell. 2012;149:22–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Buendia MA, Bourre L, Cairo S. Myc target miRs and liver cancer: small molecules to get Myc sick. Gastroenterology. 2012;142:214–8.
Article
PubMed
Google Scholar
McMahon SB. MYC and the control of apoptosis. Cold Spring Harb Perspect Med. 2014;4:a014407.
Article
PubMed
Google Scholar
Wong QW, Lung RW, Law PT, Lai PB, Chan KY, To KF, Wong N. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology. 2008;135:257–69.
Article
CAS
PubMed
Google Scholar
Dong YW, Wang R, Cai QQ, Qi B, Wu W, Zhang YH, Wu XZ. Sulfatide epigenetically regulates miR-223 and promotes the migration of human hepatocellular carcinoma cells. J Hepatol. 2014;60:792–801.
Article
CAS
PubMed
Google Scholar
Li X, Zhang Y, Zhang H, Liu X, Gong T, Li M, Sun L, Ji G, Shi Y, Han Z, et al. miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3. Mol Cancer Res. 2011;9:824–33.
Article
CAS
PubMed
Google Scholar
Li ZW, Yang YM, Du LT, Dong Z, Wang LL, Zhang X, Zhou XJ, Zheng GX, Qu AL, Wang CX. Overexpression of miR-223 correlates with tumor metastasis and poor prognosis in patients with colorectal cancer. Med Oncol. 2014;31:256.
Article
PubMed
Google Scholar
Zhang J, Luo X, Li H, Yue X, Deng L, Cui Y, Lu Y. MicroRNA-223 functions as an oncogene in human colorectal cancer cells. Oncol Rep. 2014;32:115–20.
PubMed
Google Scholar
Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH, Zhang XD. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin. 2011;32:1173–80.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lu K, Liu C, Tao T, Zhang X, Zhang L, Sun C, Wang Y, Chen S, Xu B, Chen M. MicroRNA-19a regulates proliferation and apoptosis of castration-resistant prostate cancer cells by targeting BTG1. FEBS Lett. 2015;589:1485–90.
Article
CAS
PubMed
Google Scholar
Lu WD, Zuo Y, Xu Z, Zhang M. MiR-19a promotes epithelial-mesenchymal transition through PI3 K/AKT pathway in gastric cancer. World J Gastroenterol. 2015;21:4564–73.
CAS
PubMed
PubMed Central
Google Scholar
Connolly E, Melegari M, Landgraf P, Tchaikovskaya T, Tennant BC, Slagle BL, Rogler LE, Zavolan M, Tuschl T, Rogler CE. Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype. Am J Pathol. 2008;173:856–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tan Y, Ge G, Pan T, Wen D, Chen L, Yu X, Zhou X, Gan J. A serum microRNA panel as potential biomarkers for hepatocellular carcinoma related with hepatitis B virus. PLoS One. 2014;9:e107986.
Article
PubMed
PubMed Central
Google Scholar
Li C, Wang Y, Wang S, Wu B, Hao J, Fan H, Ju Y, Ding Y, Chen L, Chu X, et al. Hepatitis B virus mrna-mediated mir-122 inhibition upregulates pttg1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion. J Virol. 2013;87:2193–205.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li G, Shen Q, Li C, Li D, Chen J, He M. Identification of circulating microRNAs as novel potential biomarkers for hepatocellular carcinoma detection: a systematic review and meta-analysis. Clin Transl Oncol. 2015;17(9):684–93.
Article
CAS
PubMed
Google Scholar
Wang Y, Gao Y, Shi W, Zhai D, Rao Q, Jia X, Liu J, Jiao X, Du Z. Profiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma. Cancer Biomark. 2015;15:177–86.
Google Scholar