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Section edited by Lotfi Chouchane
This section aims to provide a platform for research that will revolutionize patient care through the use of novel molecular predisposing screening, diagnostic, prognostic and pharmacogenomics. Advances in human genome research are opening the door to a new paradigm for practicing medicine that promises to transform healthcare. Personalized medicine will impact the way that medicine is practiced.
Pharmacogenetics driving personalized medicine: analysis of genetic polymorphisms related to breast cancer medications in Italian isolated populations
Massimiliano Cocca, et alAnti-cytokine autoantibodies in postherpetic neuralgia
Ahmad Bayat, et alComprehensive molecular characterization of human adipocytes reveals a transient brown phenotype
Andrea Guennoun, et al
Research
Malignant peripheral nerve sheath tumors (MPNST) are rare highly aggressive sarcomas that affect 8-13% of people with neurofibromatosis type 1. The prognosis for patients with MPNST is very poor. Despite TOP2A...
Journal of Translational Medicine 2013 11:213
Published on: 17 September 2013
Research
Prevalence and distribution of pathogenetic mutations in BRAF and NRAS genes were evaluated in multiple melanoma lesions from patients with different geographical origin within the same Italian population.
Journal of Translational Medicine 2013 11:202
Published on: 29 August 2013
Research
Hearing loss is caused by several environmental and genetic factors and the proportion attributed to inherited causes is assumed at 50 ~ 60% . Mutations in GJB2 and mitochondrial DNA (mtDNA) 12S rRNA are the most...
Journal of Translational Medicine 2013 11:163
Published on: 4 July 2013
Research
A successful therapeutic strategy, specifically tailored to the molecular constitution of an individual and their disease, is an ambitious objective of modern medicine. In this report, we highlight a feasibili...
Journal of Translational Medicine 2013 11:158
Published on: 1 July 2013
Research
Large databases focused on genetic susceptibility to prostate cancer have been accumulated from population studies of different ancestries, including Europeans and African-Americans. Arab populations, however,...
Journal of Translational Medicine 2013 11:121
Published on: 13 May 2013
Research
This study was designed to determine whether advanced non-small-cell lung cancer (NSCLC) patients with high copy number of epidermal growth factor receptor (EGFR) can benefit from treatment with EGFR-tyrosine ...
Journal of Translational Medicine 2013 11:90
Published on: 4 April 2013
Research
Synovial sarcoma, X breakpoint 2 interacting protein (SSX2IP), which has been identified as an acute myeloid leukemia associated antigen, is a potential target for leukemia immunotherapy. In rodents, its homol...
Journal of Translational Medicine 2013 11:52
Published on: 1 March 2013
Research
Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factor...
Journal of Translational Medicine 2012 10:235
Published on: 21 November 2012
Research
Understanding how sexual dimorphism affects the physiological and pathological responses of the immune system is of considerable clinical importance and could lead to new approaches in therapy. Sexual dimorphi...
Journal of Translational Medicine 2012 10:223
Published on: 14 November 2012
Research
Mutations in the SLC26A4 gene, which encodes the anion transporter, pendrin, are a major cause of autosomal recessive non-syndromic hearing loss (NSHL) in some Asian populations. SLC26A4 c.919-2A>G (IVS7-2A>G)...
Journal of Translational Medicine 2012 10:225
Published on: 14 November 2012
Research
The aim of this study was to assess the prognostic and predictive values of circulating tumor cell (CTC) analysis in colorectal cancer patients.
Journal of Translational Medicine 2012 10:222
Published on: 13 November 2012
Review
Disease heterogeneity is as major issue in Type II Diabetes Mellitus (T2DM), and this patient inter-variability might not be sufficiently reflected by measurements of glycated haemoglobin (HbA1c).
Journal of Translational Medicine 2012 10:214
Published on: 30 October 2012
Research
Glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49) deficiency is caused by one or more mutations in the G6PD gene on chromosome X. An association between enzyme levels and gene haplotypes remains to be establi...
Journal of Translational Medicine 2012 10:199
Published on: 24 September 2012
Research
The purpose of this study is to evaluate the predictive significance of preoperative serum level of cytokeratin 19 fragments (Cyfra21-1) and squamous cell carcinoma antigen (SCC-Ag) after complete resection in...
Journal of Translational Medicine 2012 10:197
Published on: 21 September 2012
Research
The clinical course of cutaneous melanoma (CM) can differ significantly for patients with identical stages of disease, defined clinico-pathologically, and no molecular markers differentiate patients with such ...
Journal of Translational Medicine 2012 10:185
Published on: 5 September 2012
Research
BRCA1–associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21. Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocyti...
Journal of Translational Medicine 2012 10:179
Published on: 30 August 2012
Research
Clinical dogma is that healthy urine is sterile and the presence of bacteria with an inflammatory response is indicative of urinary tract infection (UTI). Asymptomatic bacteriuria (ABU) represents the state in...
Journal of Translational Medicine 2012 10:174
Published on: 28 August 2012
Research
The aim of this study is to analyse CDKN2A methylation using pyrosequencing on a large cohort of colorectal cancers and corresponding non-neoplastic tissues. In a second step, the effect of methylation on clinica...
Journal of Translational Medicine 2012 10:173
Published on: 27 August 2012
Research
Recent studies showed that overwhelming inflammatory response mediated by the toll-like receptor (TLR)-related pathway was important in the development of acute lung injury (ALI). The aim of this study was to ...
Journal of Translational Medicine 2012 10:166
Published on: 17 August 2012
Research
This study was performed to determine if a chemotherapy-induced apoptosis assay (MiCK) could predict the best therapy for patients with ovarian cancer.
Journal of Translational Medicine 2012 10:162
Published on: 8 August 2012
