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Pain, Critical Care and Anesthesia

Section edited by Yasin S. Al Makadma and Ahmed Labib

Pain, Critical Care and Anesthesia section encompasses three major fields that are often tightly inter-related both historically and in everyday practice. A systematic Translational Medical approach may be our best route towards analysing common links and complete some of our limited understanding of common clinical pictures. Our section will also contribute in the understanding of mechanistic aspect of different anaesthetic agents and molecules and attempt to deepen the insight in the role of pharmacogenetics.

For that to happen, this section welcomes a very wide range of original research and review articles in related areas.

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  1. The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and recent epidemiological evidence has indicated an association between suboptimal vitamin C status and spinal pain. Furthermor...

    Authors: Anitra C. Carr and Cate McCall
    Citation: Journal of Translational Medicine 2017 15:77
  2. Sepsis delays wound re-epithelialization. In this study we explored the effect of human sepsis sera as well as the effects of cytokines, growth factors and exosomes of sepsis sera treated normal fibroblasts (N...

    Authors: Henna Jaurila, Vesa Koivukangas, Marjo Koskela, Fiia Gäddnäs, Sirpa Salo, Johanna Korvala, Maija Risteli, Toni Karhu, Karl-Heinz Herzig, Tuula Salo and Tero I. Ala-Kokko
    Citation: Journal of Translational Medicine 2017 15:11
  3. Extracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic hypothermia. The surv...

    Authors: Harald A. Bergan, Per S. Halvorsen, Helge Skulstad, Erik Fosse and Jan F. Bugge
    Citation: Journal of Translational Medicine 2016 14:345
  4. The C-allele of the aquaporin (AQP5) -1364A/C polymorphism is associated with decreased AQP5 expression but increased 30-day survival in patients with severe sepsis. AQP5 expression might affect survival via a...

    Authors: Katharina Rump, Matthias Unterberg, Lars Bergmann, Agnes Bankfalvi, Anil Menon, Simon Schäfer, André Scherag, Zainab Bazzi, Winfried Siffert, Jürgen Peters and Michael Adamzik
    Citation: Journal of Translational Medicine 2016 14:321
  5. Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics–pharmacodynamics (PK/PD) ...

    Authors: Valentina Selmi, Beatrice Loriga, Luca Vitali, Martina Carlucci, Alessandro Di Filippo, Giulio Carta, Eleonora Sgambati, Lorenzo Tofani, Angelo Raffaele De Gaudio, Andrea Novelli and Chiara Adembri
    Citation: Journal of Translational Medicine 2016 14:316
  6. Acute respiratory distress syndrome (ARDS) remains a common organ dysfunction in the critically ill patient. Mechanisms for its development have focused on immune mediated causes, aspects of our understanding ...

    Authors: Sean F. Monaghan, Chun-Shiang Chung, Yaping Chen, Joanne Lomas-Neira, William G. Fairbrother, Daithi S. Heffernan, William G. Cioffi and Alfred Ayala
    Citation: Journal of Translational Medicine 2016 14:312
  7. The noble gas helium induces pre- and postconditioning in animals and humans. Volatile anesthetics induce cardioprotection in humans undergoing coronary artery bypass graft (CABG) surgery. We hypothesized that...

    Authors: Kirsten F. Smit, Daniel Brevoord, Stefan De Hert, Bas A. de Mol, Raphaela P. Kerindongo, Susan van Dieren, Wolfgang S. Schlack, Markus W. Hollmann, Nina C. Weber and Benedikt Preckel
    Citation: Journal of Translational Medicine 2016 14:294
  8. Current research highlights the role of microcirculatory disorders in post-cardiac arrest patients. Affected microcirculation shows not only dissociation from systemic hemodynamics but also strong connection t...

    Authors: Petra Krupičková, Mikuláš Mlček, Michal Huptych, Zuzana Mormanová, Tomáš Bouček, Tomáš Belza, Stanislav Lacko, Miloš Černý, Petr Neužil, Otomar Kittnar, Aleš Linhart and Jan Bělohlávek
    Citation: Journal of Translational Medicine 2016 14:163
  9. Ketamine provides relief for a subset of patients with complex regional pain syndrome (CRPS). The poor responders had a lower body mass index (BMI) relative to responders. Regulation of proopiomelanocortin (PO...

    Authors: Botros B. Shenoda, Guillermo M. Alexander and Seena K. Ajit
    Citation: Journal of Translational Medicine 2016 14:64
  10. Volume resuscitation with hydroxyethyl starch (HES) is controversially discussed and we recently showed that HES perfusion impairs endothelial and epithelial intestinal barrier integrity. Here we investigated ...

    Authors: Yuk Lung Wong, Ingmar Lautenschläger, Karina Zitta, Christin Schildhauer, Kerstin Parczany, Christoph Röcken, Markus Steinfath, Norbert Weiler and Martin Albrecht
    Citation: Journal of Translational Medicine 2016 14:60
  11. The repair of organs and tissues has stepped into a prospective era of regenerative medicine. However, basic research and clinical practice in the lung regeneration remains crawling. Owing to the complicated t...

    Authors: Ce Yang, Jianxin Jiang, Xuetao Yang, Haiyan Wang and Juan Du
    Citation: Journal of Translational Medicine 2016 14:47
  12. In kidney transplantation, the conditions of organ preservation following removal influence function recovery. Current static preservation procedures are generally based on immersion in a cold-storage solution...

    Authors: Alice Faure, Laurie Bruzzese, Jean-Guillaume Steinberg, Yves Jammes, Julia Torrents, Stephane V. Berdah, Emmanuelle Garnier, Tristan Legris, Anderson Loundou, Matthieu Chalopin, Guy Magalon, Regis Guieu, Emmanuel Fenouillet and Eric Lechevallier
    Citation: Journal of Translational Medicine 2016 14:40
  13. Post-liver transplantation acute lung injury (ALI) severely affects patients’ survival, whereas the mechanism is unclear and effective therapy is lacking. The authors postulated that reperfusion-induced increa...

    Authors: Xinjin Chi, Na Guo, Weifeng Yao, Yi Jin, Wanling Gao, Jun Cai and Ziqing Hei
    Citation: Journal of Translational Medicine 2016 14:35
  14. Regional anesthesia has several advantages over general anesthesia but requires accurate needle placement to be effective. To achieve accurate placement, a needle equipped with optical fibers that allows tiss...

    Authors: Benno H. W. Hendriks, Andrea J. R. Balthasar, Gerald W. Lucassen, Marjolein van der Voort, Manfred Mueller, Vishnu V. Pully, Torre M. Bydlon, Christian Reich, Arnold T. M. H. van Keersop, Jeroen Kortsmit, Gerrit C. Langhout and Geert-Jan van Geffen
    Citation: Journal of Translational Medicine 2015 13:380
  15. Processed Chuanwu (PCW), the mother root of Aconitum carmichaelii Debeaux, has been widely used as a classic Traditional Chinese Medicine for pain relieve for over two millennia clinic...

    Authors: Chao Wang, Danni Sun, Chunfang Liu, Chunyan Zhu, Xianghong Jing, Shuping Chen, Cuiling Liu, Kai Zhi, Tengfei Xu, Hui Wang, Junling Liu, Ying Xu, Zhiqiang Liu and Na Lin
    Citation: Journal of Translational Medicine 2015 13:284
  16. Diabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. The aim of this study was to assess the effect of regional anaesthesia on post surgery opioid ...

    Authors: Anne Gomez-Brouchet, Nelly Blaes, Lionel Mouledous, Olivier Fourcade, Ivan Tack, Bernard Francès, Jean-Pierre Girolami and Vincent Minville
    Citation: Journal of Translational Medicine 2015 13:208
  17. To investigate whether pretreatment with dexmedetomidine (Dex) has a protective effect against acute lung injury (ALI) in an orthotopic autologous liver transplantation (OALT) rat model and to explore the mech...

    Authors: Xinjin Chi, Xiaoxia Wei, Wanling Gao, Jianqiang Guan, Xiaofan Yu, Yiheng Wang, Xi Li and Jun Cai
    Citation: Journal of Translational Medicine 2015 13:190
  18. Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen sp...

    Authors: Song-Xue Guo, Quan Fang, Chuan-Gang You, Yun-Yun Jin, Xin-Gang Wang, Xin-Lei Hu and Chun-Mao Han
    Citation: Journal of Translational Medicine 2015 13:183
  19. Acupuncture has analgesic effect to most pain conditions. Many neuroimaging studies were conducted to explore acupoint specificity in pain and other condition, but till now there is still discrepancy. Based on...

    Authors: Mingxiao Yang, Jie Yang, Fang Zeng, Peng Liu, Zhenhong Lai, Shufang Deng, Li Fang, Wenzhong Song, Hongjun Xie and Fanrong Liang
    Citation: Journal of Translational Medicine 2014 12:351

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