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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Osteosarcoma (OS) is the most frequent primary bone cancer, affecting mostly children and adolescents. Although much progress has been made throughout the years towards treating primary OS, the 5-year survival...

    Authors: Taiana Campos Leite, Rebecca Jean Watters, Kurt Richard Weiss and Giuseppe Intini
    Citation: Journal of Translational Medicine 2021 19:450
  2. Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of bitterness. Although in the fir...

    Authors: Kamila Tuzim and Agnieszka Korolczuk
    Citation: Journal of Translational Medicine 2021 19:440

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:478

  3. The number of older people is estimated to increase from 524 million in 2010 to 1.5 billion in 2050. The factors and models of human longevity and successful aging are questions that have intrigued individuals...

    Authors: Shihui Fu, Ping Ping, Yulong Li, Bo Li, Yali Zhao, Yao Yao and Pei Zhang
    Citation: Journal of Translational Medicine 2021 19:436
  4. Human milk is a vehicle for bioactive compounds and beneficial bacteria which promote the establishment of a healthy gut microbiome of newborns, especially of preterm infants. Pasteurized donor human milk (PDH...

    Authors: D. Mallardi, C. Tabasso, P. Piemontese, S. Morandi, T. Silvetti, F. Biscarini, P. Cremonesi, B. Castiglioni, V. Pica, M. Stuknyte, I. De Noni, O. Amato, N. Liotto, F. Mosca and P. Roggero
    Citation: Journal of Translational Medicine 2021 19:420
  5. Peritoneal dialysis (PD) is a form of dialysis to replace the function of kidney, that uses the peritoneum as a dialysis membrane to remove metabolites and water retained in the body. Vitamin D deficiency is p...

    Authors: Chi Zhang, Junsheng Wang, Xiaohui Xie and Dong Sun
    Citation: Journal of Translational Medicine 2021 19:411
  6. Metabolism is one of the most complex cellular biochemical reactions, providing energy and substances for basic activities such as cell growth and proliferation. Early studies have shown that glucose is an imp...

    Authors: Beibei Luo, Xin Zhou, Qingming Tang, Ying Yin, Guangxia Feng, Shue Li and Lili Chen
    Citation: Journal of Translational Medicine 2021 19:410
  7. Sphingosine Kinase (SphK) that catalyzes sphingosine (Sph) to sphingosine 1-phosphate (S1P), plays a key role in both sphingolipid metabolism and cellular signaling. While SphK has been implicated in type 2 di...

    Authors: Qi Chen, Wei Wang, Ming-Feng Xia, You-li Lu, Hua Bian, Chen Yu, Xiao-Ying Li, Mathew A. Vadas, Xin Gao, Huan-Dong Lin and Pu Xia
    Citation: Journal of Translational Medicine 2021 19:393
  8. Gestational diabetes mellitus (GDM) is a serious public health issue affecting 9–15% of all pregnancies worldwide. Recently, it has been suggested that extracellular vesicles (EVs) play a role throughout gesta...

    Authors: Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacós, Fátima Crispi, Gregory Duncombe, Martha Lappas…
    Citation: Journal of Translational Medicine 2021 19:360
  9. Diabetic nephropathy (DN) is a leading cause of renal failure, whereas the effective and early diagnostic biomarkers are still lacking.

    Authors: Ye Feng, Xin Zhong, Hai-Feng Ni, Cui Wang, Tao-Tao Tang, Li-Ting Wang, Kai-Yun Song, Ri-Ning Tang, Hong Liu, Bi-Cheng Liu and Lin-Li Lv
    Citation: Journal of Translational Medicine 2021 19:355
  10. Given the clinical low efficient treatment based on mono-brain-target design in Alzheimer’s disease (AD) and an increasing emphasis on microbiome-gut-brain axis which was considered as a crucial pathway to aff...

    Authors: Jie Gao, Nian Zhou, Yongkang Wu, Mengna Lu, Qixue Wang, Chenyi Xia, Mingmei Zhou and Ying Xu
    Citation: Journal of Translational Medicine 2021 19:351
  11. The roles of FTO gene and the level of serum 25-OH-vitamin D in obesity are frequently reported. This study aimed to investigate the interactions of serum 25-OH-vitamin D level, FTO and IRX3 genes expression, ...

    Authors: Maryam Gholamalizadeh, Saeid Doaei, Zohreh Mokhtari, Vahideh Jalili, Fatemeh Bourbour, Saeed Omidi, Kamal Ebrahimi, Naser Kalantari, Sheyda Abdi, Ghasem Azizi Tabesh, Mohammad Naimi Joubani, Esmaeil Roohbakhsh and Seyed Alireza Mosavi Jarrahi
    Citation: Journal of Translational Medicine 2021 19:350
  12. Chronotype is defined as a trait determining the subject circadian preference in behavioral and biological rhythms relative to external light–dark cycle. Although individual differences in chronotype have been...

    Authors: Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Roberta Modica, Daniela Laudisio, Sara Aprano, Antongiulio Faggiano, Annamaria Colao and Silvia Savastano
    Citation: Journal of Translational Medicine 2021 19:324
  13. Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease caused by severe loss of pancreatic β cells. Immune cells are key mediators of β cell destruction. This study attempted to investigate the role o...

    Authors: Jian Lin, Yuanhua Lu, Bizhou Wang, Ping Jiao and Jie Ma
    Citation: Journal of Translational Medicine 2021 19:319
  14. Sarcopenia is a loss of muscle mass and strength causing disability, morbidity, and mortality in older adults, which is characterized by alterations of the neuromuscular junctions (NMJs). SNAP-25 is essential ...

    Authors: Simone Agostini, Roberta Mancuso, Andrea Saul Costa, Franca Rosa Guerini, Fabio Trecate, Rossella Miglioli, Elisabetta Menna, Beatrice Arosio and Mario Clerici
    Citation: Journal of Translational Medicine 2021 19:315
  15. The coronavirus disease 2019 (COVID-19) pandemic has struck globally and is exerting a devastating toll on humans. The pandemic has led to calls for widespread vitamin D supplementation in public. However, evi...

    Authors: Zhiyong Cui and Yun Tian
    Citation: Journal of Translational Medicine 2021 19:300
  16. Diabetic nephropathy (DN) has an increasing global prevalence with excessive health expenditure and burden. Exosomal mRNAs regulate intercellular communications and participate in the pathogenesis of various d...

    Authors: Ehsan Hashemi, Hojat Dehghanbanadaki, Alireza Abbasi Baharanchi, Katayoon Forouzanfar, Ardeshir Kakaei, Seyed Mohammad Mohammadi, Saba Zeidi and Farideh Razi
    Citation: Journal of Translational Medicine 2021 19:299
  17. Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiol...

    Authors: Knut Sindre Mølmen, Daniel Hammarström, Gunnar Slettaløkken Falch, Morten Grundtvig, Lise Koll, Marita Hanestadhaugen, Yusuf Khan, Rafi Ahmad, Bente Malerbakken, Tore Jørgen Rødølen, Roger Lien, Bent R. Rønnestad, Truls Raastad and Stian Ellefsen
    Citation: Journal of Translational Medicine 2021 19:292
  18. Understanding the distinct patterns (trajectories) of variation in blood lipid levels before diagnosing cardiovascular disease (CVD) might carry important implications for improving disease prevention or treat...

    Authors: Fatemeh Koohi, Davood Khalili, Mohammad Ali Mansournia, Farzad Hadaegh and Hamid Soori
    Citation: Journal of Translational Medicine 2021 19:286
  19. The association between serum advanced oxidation protein products (AOPP) and mortality risk remains equivocal. We aimed to assess the correlation of serum AOPP levels with the risk of all-cause mortality in he...

    Authors: Chun Zhou, Yuanyuan Zhang, Jianghua Chen, Changlin Mei, Fei Xiong, Wei Shi, Wei Zhou, Xusheng Liu, Shiren Sun, Jianwei Tian, Ziliang Ye, Qimeng Wu, Xianhui Qin, Jianping Jiang and Fan Fan Hou
    Citation: Journal of Translational Medicine 2021 19:284
  20. Fasting plasma glucose (FPG) and 2-h post challenge plasma glucose (2 h-PCPG), whether as continuous or categorical variables, are associated with incident cardiovascular disease (CVD) and diabetes; however, t...

    Authors: Maryam Kabootari, Samaneh Asgari, Seyedeh Maryam Ghavam, Hengameh Abdi, Fereidoun Azizi and Farzad Hadaegh
    Citation: Journal of Translational Medicine 2021 19:277
  21. Obstructive sleep apnea (OSA), a sleep disorder frequently observed in individuals living with obesity, consists of repeated involuntary breathing obstructions during sleep, leading to intermittent hypoxia (IH...

    Authors: Renée Morin, Jean-François Mauger, Ruwan Amaratunga and Pascal Imbeault
    Citation: Journal of Translational Medicine 2021 19:268
  22. The hallmark of non-alcoholic fatty liver disease (NAFLD) is the excessive hepatic lipid accumulation. Currently, no pharmacotherapy exists for NAFLD. However, the glucagon-like peptide-1 receptor agonists hav...

    Authors: Khaoula Errafii, Neyla S. Al-Akl, Olfa Khalifa and Abdelilah Arredouani
    Citation: Journal of Translational Medicine 2021 19:235
  23. Alcohol consumption is one of the modifiable risk factors for intracerebral hemorrhage, which accounts for approximately 10–20% of all strokes worldwide. We evaluated the association of stroke with genetic pol...

    Authors: Chun-Hsiang Lin, Oswald Ndi Nfor, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Yi-Chia Liaw, Mochly-Rosen Daria, Che-Hong Chen and Yung-Po Liaw
    Citation: Journal of Translational Medicine 2021 19:227
  24. Until now, epidemiological evidence regarding the association between vitamin C intake (both diet and supplements) and Parkinson’s disease (PD) remains inconsistent. Hence, it is necessary to establish the cau...

    Authors: Haijie Liu, Yan Zhang, Haihua Zhang, Longcai Wang, Tao Wang, Zhifa Han, Liyong Wu and Guiyou Liu
    Citation: Journal of Translational Medicine 2021 19:221
  25. The intestinal barrier plays an important role in the defense against infections, and nutritional, endocrine, and immune functions. The gut microbiota playing an important role in development of the gastrointe...

    Authors: Mariusz Kaczmarczyk, Ulrike Löber, Karolina Adamek, Dagmara Węgrzyn, Karolina Skonieczna-Żydecka, Damian Malinowski, Igor Łoniewski, Lajos Markó, Thomas Ulas, Sofia K. Forslund and Beata Łoniewska
    Citation: Journal of Translational Medicine 2021 19:177
  26. sarcopenia is a highly prevalent condition in elderly individuals which is characterized by loss of muscle mass and functions; recent results showed that it is also associated with inflammation. Rehabilitation...

    Authors: Francesca La Rosa, Simone Agostini, Marina Saresella, Andrea Saul Costa, Federica Piancone, Rossella Miglioli, Fabio Trecate and Mario Clerici
    Citation: Journal of Translational Medicine 2021 19:172
  27. Acne is a chronic, inflammatory and debilitating skin disorder. Dietary factors and nutritional status are among the exacerbating factors of acne. Phase angle (PhA), a direct measure of Bioelectrical Impedance...

    Authors: Luigi Barrea, Marianna Donnarumma, Sara Cacciapuoti, Giovanna Muscogiuri, Ludovica De Gregorio, Chiara Blasio, Silvia Savastano, Annamaria Colao and Gabriella Fabbrocini
    Citation: Journal of Translational Medicine 2021 19:171
  28. Vitamin D status in patients with COVID-19 is an on-going controversial issue. This study aims to determine differences in the serum 25(OH)D concentrations of Arab Gulf adult residents screened for SARS-CoV-2 ...

    Authors: Nasser M. Al-Daghri, Osama E. Amer, Naif H. Alotaibi, Dara A. Aldisi, Mushira A. Enani, Eman Sheshah, Naji J. Aljohani, Naemah Alshingetti, Suliman Y. Alomar, Hanan Alfawaz, Syed D. Hussain, Abdullah M. Alnaami and Shaun Sabico
    Citation: Journal of Translational Medicine 2021 19:166
  29. Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, w...

    Authors: Emma Stolt, Thomas Olsen, Amany Elshorbagy, Viktor Kožich, Marleen van Greevenbroek, Bente Øvrebø, Magne Thoresen, Helga Refsum, Kjetil Retterstøl and Kathrine J. Vinknes
    Citation: Journal of Translational Medicine 2021 19:153
  30. Nonalcoholic fatty liver disease (NAFLD) is a common metabolic disease that affects 20–30% of individuals worldwide. Liver puncture remains the gold standard for the diagnosis of liver diseases despite limitat...

    Authors: Cheng Hu, Tao Wang, Xiaoyu Zhuang, Qiaoli Sun, Xiaochun Wang, Hui Lin, Mingli Feng, Jiaqi Zhang, Qin Cao and Yuanye Jiang
    Citation: Journal of Translational Medicine 2021 19:152

    The Correction to this article has been published in Journal of Translational Medicine 2022 20:24

  31. Time-restricted feeding (TRF) is a form of intermittent fasting, which is beneficial for weight loss and cardiometabolic health. Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrin...

    Authors: Chunzhu Li, Chuan Xing, Jiaqi Zhang, Han Zhao, Wenjing Shi and Bing He
    Citation: Journal of Translational Medicine 2021 19:148
  32. Coronavirus disease (COVID-19) pandemic has affected health and lifestyle behaviors of people globally. This project aims to identify the impact of COVID-19 on lifestyle behavior of individuals in the Middle E...

    Authors: Mohamed Abouzid, Dina M. El-Sherif, Nael Kamel Eltewacy, Nesrine Ben Hadj Dahman, Salah A. Okasha, Sherief Ghozy and Sheikh Mohammed Shariful Islam
    Citation: Journal of Translational Medicine 2021 19:129
  33. Omega-3 polyunsaturated fatty acids (n3-PUFAs) may exert beneficial effects on the immune system of patients with viral infections. This paper aimed to examine the effect of n3-PUFA supplementation on inflamma...

    Authors: Saeid Doaei, Somayeh Gholami, Samira Rastgoo, Maryam Gholamalizadeh, Fatemeh Bourbour, Seyedeh Elaheh Bagheri, Forough Samipoor, Mohammad Esmail Akbari, Mahdi Shadnoush, Fereshteh Ghorat, Seyed Alireza Mosavi Jarrahi, Narjes Ashouri Mirsadeghi, Azadeh Hajipour, Parvin Joola, Alireza Moslem and Mark O. Goodarzi
    Citation: Journal of Translational Medicine 2021 19:128

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2021 19:282

  34. Muscle wasting, low protein intake, hypoalbuminemia, low body mass, and chronic fatigue are prevalent in hemodialysis patients. Impaired creatine status may be an often overlooked, potential contributor to the...

    Authors: Adrian Post, Joëlle C. Schutten, Daan Kremer, Yvonne van der Veen, Dion Groothof, Camilo G. Sotomayor, Christa A. Koops, Pim de Blaauw, Ido P. Kema, Ralf Westerhuis, Theo Wallimann, M. Rebecca Heiner-Fokkema, Stephan J. L. Bakker and Casper F. M. Franssen
    Citation: Journal of Translational Medicine 2021 19:115
  35. Non-alcoholic steatohepatitis (NASH) is a key stage in leading development of non-alcoholic simple fatty liver (NAFL) into cirrhosis and even liver cancer. This study aimed at exploring the lncRNAs expression ...

    Authors: Liangying Ye, Dan Zhao, Yangzhi Xu, Jiaen Lin, Jiahui Xu, Kunyuan Wang, Zhanhui Ye, Yufeng Luo, Shiming Liu and Hui Yang
    Citation: Journal of Translational Medicine 2021 19:101
  36. To identify sex specific trajectories of waist circumference (WC),triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and fasting plasma glucose (FPG) during adulthood and e...

    Authors: Noushin Sadat Ahanchi, Seyed Saeed Tamehri Zadeh, Davood Khalili, Fereidoun Azizi and Farzad Hadaegh
    Citation: Journal of Translational Medicine 2021 19:84
  37. Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are highly prevalent comorbidities in patients with Type 2 diabetes. While many of these patients eventually will need treatme...

    Authors: Victoria Svop Jensen, Christian Fledelius, Christina Zachodnik, Jesper Damgaard, Helle Nygaard, Kristina Steinicke Tornqvist, Rikke Kaae Kirk, Birgitte Martine Viuff, Erik Max Wulff, Jens Lykkesfeldt and Henning Hvid
    Citation: Journal of Translational Medicine 2021 19:80
  38. The prevalence of metabolic syndrome (Mets) is closely related to an increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, h...

    Authors: Zhoujie Tong, Jie Peng, Hongtao Lan, Wenwen Sai, Yulin Li, Jiaying Xie, Yanmin Tan, Wei Zhang, Ming Zhong and Zhihao Wang
    Citation: Journal of Translational Medicine 2021 19:72
  39. Atherosclerosis is a chronic vascular disease posing a great threat to public health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities to inhibit lipid accumulation and polarization co...

    Authors: Xinxin Zhang, Yating Qin, Xiaoning Wan, Hao Liu, Chao Lv, Weibin Ruan, Lin He, Li Lu and Xiaomei Guo
    Citation: Journal of Translational Medicine 2021 19:62
  40. Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes ...

    Authors: Wei Pan, Pengfei Jiang, Jinxiu Zhao, Hongli Shi, Peng Zhang, Xiaoying Yang, Joanna Biazik, Minmin Hu, Hui Hua, Xing Ge, Xu-Feng Huang and Yinghua Yu
    Citation: Journal of Translational Medicine 2021 19:54
  41. Interleukin-33 (IL-33) plays a pivotal role in regulating innate immune response and metabolic homeostasis. However, whether its circulating level is correlated with obesity and metabolic disorders in humans r...

    Authors: Haoneng Tang, Ning Liu, Xiaojing Feng, Yanyi Yang, Yiyuan Fang, Siqi Zhuang, Yufeng Dai, Meilian Liu and Lingli Tang
    Citation: Journal of Translational Medicine 2021 19:52
  42. By binding to negatively charged polysaccharides called glycosaminoglycans, sodium can be stored in the body—particularly in the skin—without concurrent water retention. Concordantly, individuals with changed ...

    Authors: Eliane F. E. Wenstedt, Jetta J. Oppelaar, Stijn Besseling, Nienke M. G. Rorije, Rik H. G. Olde Engberink, Arie Oosterhof, Toin H. van Kuppevelt, Bert-Jan H. van den Born, Jan Aten and Liffert Vogt
    Citation: Journal of Translational Medicine 2021 19:38
  43. Benign prostatic hyperplasia (BPH) is the most common urologic disease among elderly men. The diagnosis of BPH is usually driven by lower urinary tract symptoms (LUTS) that can significantly affect patients’ q...

    Authors: Luigi Cormio, Beppe Calò, Ugo Falagario, Manuela Iezzi, Alessia Lamolinara, Paola Vitaglione, Giovanni Silecchia, Giuseppe Carrieri, Vincenzo Fogliano, Stefano Iacobelli, Pier Giorgio Natali and Mauro Piantelli
    Citation: Journal of Translational Medicine 2021 19:24

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