Skip to main content

Immunobiology and Immunotherapy

Section edited by Alessandra Cesano

The Immunobiology and Immunotherapy section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Pedro Romero was the founding Section Editor.

Page 2 of 9

  1. Silicosis is one of the most common occupational pulmonary fibrosis caused by respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a commonly used biguanide antidiabetic agent,...

    Authors: Demin Cheng, Qi Xu, Yue Wang, Guanru Li, Wenqing Sun, Dongyu Ma, Siyun Zhou, Yi Liu, Lei Han and Chunhui Ni
    Citation: Journal of Translational Medicine 2021 19:349
  2. Kidney transplantation is an optimal method for treatment of end-stage kidney failure. However, kidney transplant rejection (KTR) is commonly observed to have negative effects on allograft function. MicroRNAs ...

    Authors: Yuxin Lin, Liangliang Wang, Wenqing Ge, Yu Hui, Zheng Zhou, Linkun Hu, Hao Pan, Yuhua Huang and Bairong Shen
    Citation: Journal of Translational Medicine 2021 19:346
  3. We tried to elaborate the molecular mechanism of ETS-like transcription factor 4 (ELK4) affecting gastric cancer (GC) progression through M2 polarization of macrophages mediated by lysine-specific demethylase ...

    Authors: Lei Zheng, Hongmei Xu, Ya Di, Lanlan Chen, Jiao Liu, Liying Kang and Liming Gao
    Citation: Journal of Translational Medicine 2021 19:342
  4. Biomarkers for distinguishing psoriatic arthritis (PsA) from psoriasis without arthritis (PsO) are still lacking.

    Authors: Jie Zhu, Ling Han, Ruilai Liu, Zhenghua Zhang, Qiong Huang, Xu Fang, Ke Yang, Guiqin Huang, Zhizhong Zheng, Nikhil Yawalkar, Hui Deng and Kexiang Yan
    Citation: Journal of Translational Medicine 2021 19:331
  5. Tumor microenvironment (TME) is associated with tumor progression and prognosis. Previous studies provided tools to estimate immune and stromal cell infiltration in TME. However, there is still a lack of singl...

    Authors: Zihang Zeng, Jiali Li, Jianguo Zhang, Yangyi Li, Xingyu Liu, Jiarui Chen, Zhengrong Huang, Qiuji Wu, Yan Gong and Conghua Xie
    Citation: Journal of Translational Medicine 2021 19:330
  6. Accumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs in CD4+ T cells from patients with systemic lupus er...

    Authors: Guannan Geng, Huijing Wang, Weiwei Xin, Zhe Liu, Jie Chen, Zhang Danting, Fei Han and Shuang Ye
    Citation: Journal of Translational Medicine 2021 19:305
  7. Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity I...

    Authors: Hui-Na Wang, Kunmei Ji, Li-Na Zhang, Chu-Chu Xie, Wei-Yong Li, Zhen-Fu Zhao and Jia-Jie Chen
    Citation: Journal of Translational Medicine 2021 19:261
  8. Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this ...

    Authors: Wendi Wei, Weida Chen and Naifeng He
    Citation: Journal of Translational Medicine 2021 19:258
  9. Recent studies reporting the intricate crosstalk between cellular and molecular mediators and the lymphatic endothelium in the development of inflammatory bowel diseases (IBD) suggest altered inflammatory cell...

    Authors: Dickson Kofi Wiredu Ocansey, Bing Pei, Xinwei Xu, Lu Zhang, Chinasa Valerie Olovo and Fei Mao
    Citation: Journal of Translational Medicine 2021 19:254
  10. N6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human dise...

    Authors: Chang Liu, Zhe Yang, Rong Li, Yanju Wu, Ming Chi, Shuting Gao, Xun Sun, Xin Meng and Biao Wang
    Citation: Journal of Translational Medicine 2021 19:251
  11. Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder of the gastrointestinal tract and comprises ulcerative colitis (UC) and Crohn’s disease (CD). Crohn’s disease can affect any p...

    Authors: Ilkyu Park, Jaeeun Jung, Sugi Lee, Kunhyang Park, Jea-Woon Ryu, Mi-Young Son, Hyun-Soo Cho and Dae-Soo Kim
    Citation: Journal of Translational Medicine 2021 19:250

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:329

  12. Programmed cell death ligand-1 (PD-L1) expression is a promising biomarker for identifying treatment related to non-small cell lung cancer (NSCLC). Automated image analysis served as an aided PD-L1 scoring too...

    Authors: Boju Pan, Yuxin Kang, Yan Jin, Lin Yang, Yushuang Zheng, Lei Cui, Jian Sun, Jun Feng, Yuan Li, Lingchuan Guo and Zhiyong Liang
    Citation: Journal of Translational Medicine 2021 19:249
  13. Recently, increased interleukin (IL)-24 expression has been demonstrated in the colon biopsies of adult patients with inflammatory bowel disease (IBD). However, the role of IL-24 in the pathomechanism of IBD i...

    Authors: Anna Ónody, Apor Veres-Székely, Domonkos Pap, Réka Rokonay, Beáta Szebeni, Erna Sziksz, Franz Oswald, Gábor Veres, Áron Cseh, Attila J. Szabó and Ádám Vannay
    Citation: Journal of Translational Medicine 2021 19:237
  14. The main limitation of current immune checkpoint inhibitors (ICIs) in the treatment of cervical cancer comes from the fact that it benefits only a minority of patients. The study aims to develop a classificati...

    Authors: Yimin Li, Shun Lu, Shubin Wang, Xinhao Peng and Jinyi Lang
    Citation: Journal of Translational Medicine 2021 19:222
  15. The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between the gut and brain, and is increasingly recognized as playing a central role in physiology and disease. MicroRNAs are import...

    Authors: Liang Zhao, Yingze Ye, Lijuan Gu, Zhihong Jian, Creed M. Stary and Xiaoxing Xiong
    Citation: Journal of Translational Medicine 2021 19:202
  16. Scleroderma is an autoimmune disease that causes dermal fibrosis. It occurs when collagen accumulates in tissue as a result of persistent inflammation. Th17 cells and pro-inflammatory cytokines such as IL-1β,...

    Authors: Jeonghyeon Moon, Seon-yeong Lee, Jeong Won Choi, A Ram Lee, Jin Hee Yoo, Su-Jin Moon, Sung-Hwan Park and Mi-La Cho
    Citation: Journal of Translational Medicine 2021 19:192

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:266

  17. T cells and B cells play a key role in alloimmune responses. We aimed to characterize the shift of T cell subsets and B cell subsets during acute hepatic rejection, and further determine whether they could ser...

    Authors: Ji-Qiao Zhu, Jing Wang, Xian-Liang Li, Wen-Li Xu, Shao-cheng Lv, Xin Zhao, Ren Lang and Qiang He
    Citation: Journal of Translational Medicine 2021 19:187
  18. New medications for Rheumatoid Arthritis (RA) have emerged in the last decades, including Disease Modifying Antirheumatic Drugs (DMARDs) and biologics. However, there is no known cure, since a significant prop...

    Authors: Lydia Ntari, Christoforos Nikolaou, Ksanthi Kranidioti, Dimitra Papadopoulou, Eleni Christodoulou-Vafeiadou, Panagiotis Chouvardas, Florian Meier, Christina Geka, Maria C. Denis, Niki Karagianni and George Kollias
    Citation: Journal of Translational Medicine 2021 19:165
  19. Osteoarthritis (OA) is a disease of the entire joint involving synovial fibrosis and inflammation. Pathological changes to the synovium can accelerate the progression of OA. Pirfenidone (PFD) is a potent anti-...

    Authors: Qilu Wei, Ning Kong, Xiaohui Liu, Run Tian, Ming Jiao, Yiyang Li, Huanshuai Guan, Kunzheng Wang and Pei Yang
    Citation: Journal of Translational Medicine 2021 19:157

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:434

  20. Modification of the gut microbiota by antibiotics may influence the disease susceptibility and immunological responses. Infants in the neonatal intensive care unit (NICU) subjected to frequent antibiotics and ...

    Authors: Xiao Ran, Yu He, Qing Ai and Yuan Shi
    Citation: Journal of Translational Medicine 2021 19:155
  21. Lung cancer is the most common cancer and cause of cancer‐related mortality worldwide, increasing evidence indicated that there was a significant correlation between tumors and the long non‐coding RNAs (lncRNA...

    Authors: Lan Mu, Ke Ding, Ranran Tu and Wei Yang
    Citation: Journal of Translational Medicine 2021 19:127
  22. Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induces uncontrolled and self-amplified pulmonary inflammation, and has high morbidity and mortality rates in critically ill patients. In rece...

    Authors: Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv and Wei Han
    Citation: Journal of Translational Medicine 2021 19:96
  23. Regimens combining pemetrexed (PEM) and immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1) or programmed death-ligand 1 (PD-L1) are widely used for the treatment of advanced non-squam...

    Authors: Issei Sumiyoshi, Takahiro Okabe, Shinsaku Togo, Haruhi Takagi, Hiroaki Motomura, Yusuke Ochi, Naoko Shimada, Mizuki Haraguchi, Rina Shibayama, Yuichi Fujimoto, Junko Watanabe, Moe Iwai, Kotaro Kadoya, Shin-ichiro Iwakami and Kazuhisa Takahashi
    Citation: Journal of Translational Medicine 2021 19:92
  24. Autoantibody production against endogenous cellular components is pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (TFH) cells aid in B cell differentiation into autoantibody-producin...

    Authors: Se Gwang Jang, Jaeseon Lee, Seung-Min Hong, Young-Seok Song, Min Jun Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2021 19:86
  25. Systemic lupus erythematosus (SLE) is a multisystemic, chronic inflammatory disease characterized by destructive systemic organ involvement, which could cause the decreased functional capacity, increased morbi...

    Authors: Xingwang Zhao, Longlong Zhang, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni and Yi You
    Citation: Journal of Translational Medicine 2021 19:35

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:64

  26. Although the tumour immune microenvironment is known to significantly influence immunotherapy outcomes, its association with changes in gene expression patterns in hepatocellular carcinoma (HCC) during immunot...

    Authors: Xinyu Gu, Jun Guan, Jia Xu, Qiuxian Zheng, Chao Chen, Qin Yang, Chunhong Huang, Gang Wang, Haibo Zhou, Zhi Chen and Haihong Zhu
    Citation: Journal of Translational Medicine 2021 19:26
  27. Immune checkpoint inhibitors (ICIs) have become a frontier in the field of clinical technology for advanced non-small cell lung cancer (NSCLC). Currently, the predictive biomarker of ICIs mainly including the ...

    Authors: Li Wang, Zhixuan Ren, Bentong Yu and Jian Tang
    Citation: Journal of Translational Medicine 2021 19:22
  28. Metabolic cell features are able to give reliable information on cell functional state. Thus, metabolic potential assessment of T cells in malignancy setting represents a promising area, especially in adoptive...

    Authors: Patricia Mercier-Letondal, Chrystel Marton, Yann Godet and Jeanne Galaine
    Citation: Journal of Translational Medicine 2021 19:21
  29. Rheumatoid arthritis (RA) is the most common chronic autoimmune connective tissue disease. However, early RA is difficult to diagnose due to the lack of effective biomarkers. This study aimed to identify new b...

    Authors: Qi Cheng, Xin Chen, Huaxiang Wu and Yan Du
    Citation: Journal of Translational Medicine 2021 19:18
  30. Inflammatory disorders like diabetes, systemic lupus erythematodes, inflammatory lung diseases, rheumatoid arthritis and multiple sclerosis, but also rejection of transplanted organs and GvHD, form a major bur...

    Authors: Sija Landman, Chiel van der Horst, Piet E. J. van Erp, Irma Joosten, Rob de Vries and Hans J. P. M. Koenen
    Citation: Journal of Translational Medicine 2021 19:11
  31. Ankylosing spondylitis (AS) is characterized by excessive production of inflammatory cytokines. Recent evidence suggests that inflammation underlies the neurodegenerative process of Parkinson’s disease (PD). W...

    Authors: Fu-Chiang Yeh, Hsiang-Cheng Chen, Yu-Ching Chou, Cheng-Li Lin, Chia-Hung Kao, Hsin-Yi Lo, Feng-Cheng Liu and Tse-Yen Yang
    Citation: Journal of Translational Medicine 2020 18:455
  32. Dysregulation of transcription and cytokine expression has been implicated in the pathogenesis of a variety inflammatory diseases. The resulting imbalance between inflammatory and resolving transcriptional pro...

    Authors: Gregory Thomas, Elizabeth Frederick, Lisa Thompson, Raphael Bar-Or, Yetti Mulugeta, Melissa Hausburg, Michael Roshon, Charles Mains and David Bar-Or
    Citation: Journal of Translational Medicine 2020 18:452
  33. Thymocyte-expressed, positive selection-associated 1 (Tespa1) is a critical signaling molecule in thymocyte development. This study aimed to investigate the regulatory effect of Tespa1 on mast cells in the pat...

    Authors: Ruhui Yang, Guangli Wang, Lingyun Li, Hanjiang He, Mingzhu Zheng, Linrong Lu and Songquan Wu
    Citation: Journal of Translational Medicine 2020 18:444
  34. Immunity reaction plays an essential role in periodontitis progress and we aim to investigate the underlying regulatory network of immune reactions in periodontitis.

    Authors: Xiaoqi Zhang, Qingxuan Wang, Xinyu Yan, Yue Shan, Lu Xing, Minqi Li, Hu Long and Wenli Lai
    Citation: Journal of Translational Medicine 2020 18:438
  35. Neutrophil extracellular traps (NETs) from patients with systemic lupus erythematosus (SLE) are characterized by lower ubiquitylation and myeloperoxidase (MPO) as a substrate. The structural and functional eff...

    Authors: Daniel Alberto Carrillo-Vázquez, Eduardo Jardón-Valadez, Jiram Torres-Ruiz, Guillermo Juárez-Vega, José Luis Maravillas-Montero, David Eduardo Meza-Sánchez, María Lilia Domínguez-López, Jorge Carlos Alcocer Varela and Diana Gómez-Martín
    Citation: Journal of Translational Medicine 2020 18:429
  36. Foxp3+ regulatory T cells (Tregs) play essential roles in immune homeostasis and repair of damaged lung tissue. We hypothesized that patients whose lung injury resolves quickly, as measured by time to liberation ...

    Authors: Dustin L. Norton, Agathe Ceppe, Miriya K. Tune, Matthew McCravy, Thomas Devlin, M. Bradley Drummond, Shannon S. Carson, Benjamin G. Vincent, Robert S. Hagan, Hong Dang, Claire M. Doerschuk and Jason R. Mock
    Citation: Journal of Translational Medicine 2020 18:427
  37. Numerous tissue-derived factors have been postulated to be involved in tissue migration of circulating monocytes. The aim of this study was to evaluate whether a defined hypoxic gradient can induce directed mi...

    Authors: Lars Hummitzsch, Rouven Berndt, Matthias Kott, Rene Rusch, Fred Faendrich, Matthias Gruenewald, Markus Steinfath, Martin Albrecht and Karina Zitta
    Citation: Journal of Translational Medicine 2020 18:404
  38. In Crohn’s disease (CD), one of the major inflammatory bowel disease (IBD) in human beings, there is over-expression of Smad7, an intracellular inhibitor of the suppressive cytokine TGF-β1. The aim of this stu...

    Authors: Francesca Zorzi, Emma Calabrese, Davide Di Fusco, Elena De Cristofaro, Livia Biancone, Sara Casella, Giampiero Palmieri and Giovanni Monteleone
    Citation: Journal of Translational Medicine 2020 18:395
  39. Rheumatoid arthritis (RA) and periodontitis (PD) are proven to share common risk markers, including genetic factors. In the present study we focused on genetic variants in PTPN22 (rs2476601), PADI4 (rs2240340), C...

    Authors: Susanne Schulz, Pauline Zimmer, Natalie Pütz, Elisa Jurianz, Hans-Günter Schaller and Stefan Reichert
    Citation: Journal of Translational Medicine 2020 18:389
  40. Autoimmune hepatitis (AIH) is a liver disease characterized by the autoimmune-induced injury of hepatocytes which can lead to cirrhosis and hepatic failure. The diagnosis and disease management of AIH patients...

    Authors: Rui Wu, Yan Liu, Ruyu Yan, Xiaoyu Liu and Liang Duan
    Citation: Journal of Translational Medicine 2020 18:384
  41. The study of localized immune-related factors has proven beneficial for a variety of conditions, and one area of interest in the field of orthopaedics is the impact of implants and localized infections on immu...

    Authors: Nicole Prince, Julia A. Penatzer, Matthew J. Dietz and Jonathan W. Boyd
    Citation: Journal of Translational Medicine 2020 18:330
  42. To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells.

    Authors: Jooyeon Jhun, Hong Ki Min, Jaeyoon Ryu, Seon-Yeong Lee, Jun-Geol Ryu, Jeong Won Choi, Hyun Sik Na, Seung Yoon Lee, Yunju Jung, Sang-Jun Park, Myeong Soo Park, Bin Kwon, Geun Eog Ji, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2020 18:317
  43. Fibrinogen-like protein 1 (FGL1)—Lymphocyte activating gene 3 (LAG-3) pathway is a promising immunotherapeutic target and has synergistic effect with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1)...

    Authors: Mengzhou Guo, Feifei Yuan, Feng Qi, Jialei Sun, Qianwen Rao, Zhiying Zhao, Peixin Huang, Tingting Fang, Biwei Yang and Jinglin Xia
    Citation: Journal of Translational Medicine 2020 18:306
  44. Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their cl...

    Authors: Hyun Sik Na, Seon-yeong Lee, Hong Ki Min, Wan-je Park, Jung-hwan Lee, Ka-hee Cho, Shin-hee Hong, Dae-hoon Kim, Jooyeon Jhun, Jeong-Won Choi, Sung-Min Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2020 18:264
  45. Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansio...

    Authors: Adam Brufsky, Juan Luis Gomez Marti, Azadeh Nasrazadani and Michael T. Lotze
    Citation: Journal of Translational Medicine 2020 18:261
  46. Pools of overlapping synthetic peptides are routinely used for ex vivo monitoring of antigen-specific T-cell responses. However, it is rather unlikely that these peptides match those resulting from naturally p...

    Authors: Nina Körber, Uta Behrends, Ulrike Protzer and Tanja Bauer
    Citation: Journal of Translational Medicine 2020 18:242
  47. Fibrosis is the formation of excess connective tissue in an organ or tissue during a reparative or reactive process. Graft-versus-host disease (GvHD) is a medical complication of allogeneic tissue transplantat...

    Authors: Jaeyoon Ryu, Jooyeon Jhun, Min-Jung Park, Jin-ah Baek, Se-Young Kim, Keun-Hyung Cho, Jeong-Won Choi, Sung-Hwan Park, Jong Young Choi and Mi-La Cho
    Citation: Journal of Translational Medicine 2020 18:225

Annual Journal Metrics

  • 2022 Citation Impact
    7.4 - 2-year Impact Factor
    6.9 - 5-year Impact Factor
    1.458 - SNIP (Source Normalized Impact per Paper)
    1.544 - SJR (SCImago Journal Rank)

    2022 Speed
    10 days submission to first editorial decision for all manuscripts (Median)
    84 days submission to accept (Median)

    2022 Usage 
    4,243,080 downloads
    32,614 Altmetric mentions