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Immunobiology and Immunotherapy

Section edited by Alessandra Cesano

The Immunobiology and Immunotherapy section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Pedro Romero was the founding Section Editor.

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  1. TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and a potential target for cancer immunotherapy. In our study, we evaluated the role of TIGIT/CD155 checkpoints in the progression of c...

    Authors: Lu Liu, Aihong Wang, Xiaoli Liu, Sai Han, Yu Sun, Junhua Zhang, Lingyu Guo and Youzhong Zhang
    Citation: Journal of Translational Medicine 2022 20:280
    Content type: Research Published on:

  2. High immune infiltration is associated with favourable prognosis in patients with non-small-cell lung cancer (NSCLC), but an automated workflow for characterizing immune infiltration, with high validity and re...

    Authors: Huan Lin, Xipeng Pan, Zhengyun Feng, Lixu Yan, Junjie Hua, Yanting Liang, Chu Han, Zeyan Xu, Yumeng Wang, Lin Wu, Yanfen Cui, Xiaomei Huang, Zhenwei Shi, Xin Chen, Xiaobo Chen, Qingling Zhang…
    Citation: Journal of Translational Medicine 2022 20:261
    Content type: Research Published on:

  5. Spondyloarthritis (SpA) and rheumatoid arthritis (RA) are chronic autoimmune diseases, but they are usually difficult to distinguish in the early stage of the diseases. The purpose of this study is to explore ...

    Authors: Jiaqian Wang, Yuan Xue and Liang Zhou
    Citation: Journal of Translational Medicine 2022 20:196
    Content type: Research Published on:

  6. Pemphigus is an autoimmune skin disease. Ectopic lymphoid-like structures (ELSs) were found to be commonly present in the pemphigus lesions, presumably supporting in situ desmoglein (Dsg)-specific antibody pro...

    Authors: Zi-xuan Huang, Peng Qu, Kan-kan Wang, Jie Zheng, Meng Pan and Hai-qin Zhu
    Citation: Journal of Translational Medicine 2022 20:182
    Content type: Research Published on:

  7. To evaluate the capability of basal and one-month differed white blood cells (WBC), neutrophil, lymphocyte and platelet values and their ratios (neutrophils-to-lymphocytes ratio, NLR, and platelets-to-lymphocy...

    Authors: Michele Guida, Nicola Bartolomeo, Davide Quaresmini, Pietro Quaglino, Gabriele Madonna, Jacopo Pigozzo, Anna Maria Di Giacomo, Alessandro Marco Minisini, Marco Tucci, Francesco Spagnolo, Marcella Occelli, Laura Ridolfi, Paola Queirolo, Ivana De Risi, Monica Valente, Angela Monica Sciacovelli…
    Citation: Journal of Translational Medicine 2022 20:159
    Content type: Research Published on:

  8. The phagocytosis checkpoints of CD47/SIRPα, PD1/PDL1, CD24/SIGLEC10, and MHC/LILRB1 have shown inhibited phagocytosis of macrophages in distinct tumors. However, phagocytosis checkpoints and their therapeutic ...

    Authors: Hui Yang, Meimei Yan, Wei Li and Linping Xu
    Citation: Journal of Translational Medicine 2022 20:140
    Content type: Research Published on:

  9. Immune checkpoint blockade therapy has revolutionized non-small cell lung cancer treatment. However, not all patients respond to this therapy. Assessing the tumor expression of immune checkpoint molecules, inc...

    Authors: Yen-Yu Lin, Lei-Chi Wang, Yu-Han Hsieh, Yu-Ling Hung, Yung-An Chen, Yu-Chieh Lin, Yen-Yin Lin and Teh-Ying Chou
    Citation: Journal of Translational Medicine 2022 20:131
    Content type: Research Published on:

  10. Autoimmunity has emerged as a characteristic of the post-COVID syndrome (PCS), which may be related to sex. In order to further investigate the relationship between SARS-CoV-2 and autoimmunity in PCS, a clinic...

    Authors: Manuel Rojas, Yhojan Rodríguez, Yeny Acosta-Ampudia, Diana M. Monsalve, Chengsong Zhu, Quan-Zhen Li, Carolina Ramírez-Santana and Juan-Manuel Anaya
    Citation: Journal of Translational Medicine 2022 20:129
    Content type: Commentary Published on:

  11. Triple negative breast cancer (TNBC) is an aggressive breast cancer for which there is currently no targeted therapy. Tumor-infiltrating B-cells (TIB) have been observed in tumor tissues of TNBC patients, but ...

    Authors: Nicole J. Toney, Lynn M. Opdenaker, Kader Cicek, Lisa Frerichs, Christopher Ryan Kennington, Samuel Oberly, Holly Archinal, Rajasekharan Somasundaram and Jennifer Sims-Mourtada
    Citation: Journal of Translational Medicine 2022 20:112
    Content type: Research Published on:

  12. Graft-versus-host disease (GvHD) is a critical complication after allogeneic hematopoietic stem cell transplantation (HSCT). The immunosuppressants given to patients undergoing allogeneic HSCT disturb the microbi...

    Authors: Jin-Ah Beak, Min-Jung Park, Se-Young Kim, JooYeon Jhun, Jin Seok Woo, Jeong Won Choi, Hyun Sik Na, Soon Kyu Lee, Jong Young Choi and Mi-La Cho
    Citation: Journal of Translational Medicine 2022 20:104
    Content type: Research Published on:

  13. Interstitial cystitis/bladder pain syndrome (IC/BPS) is a disorder characterized by bladder pain upon filling which severely affects quality of life. Clinical presentation can vary. Local inflammatory events t...

    Authors: Robert M. Moldwin, Vishaan Nursey, Oksana Yaskiv, Siddhartha Dalvi, Eric J. Macdonald, Michael Funaro, Chengliang Zhang, William DeGouveia, Marina Ruzimovsky, Horacio R. Rilo, Edmund J. Miller, Souhel Najjar, Inna Tabansky and Joel N. H. Stern
    Citation: Journal of Translational Medicine 2022 20:97
    Content type: Research Published on:

  14. Rheumatoid arthritis (RA) is a progressive systemic autoimmune disease that is characterized by infiltration of inflammatory cells into the hyperplastic synovial tissue, resulting in subsequent destruction of ...

    Authors: Jin-Sil Park, Donghyun Lee, SeungCheon Yang, Ha Yeon Jeong, Hyun Sik Na, Keun-Hyung Cho, JeongWon Choi, Heebeom Koo, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2022 20:85
    Content type: Research Published on:

  15. Natural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim of this study was to investigate the prognostic significance and functional implication ...

    Authors: Hee Young Na, Yujun Park, Soo Kyung Nam, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Kyu Sang Lee and Hye Seung Lee
    Citation: Journal of Translational Medicine 2021 19:529
    Content type: Research Published on:

  16. Osteoarthritis (OA), which is due to the progressive loss and degeneration of articular cartilage, is the leading cause of disability worldwide. Therefore, it is of great significance to explore OA biomarkers ...

    Authors: YaGuang Han, Jun Wu, ZhenYu Gong, YiQin Zhou, HaoBo Li, Bo Wang and QiRong Qian
    Citation: Journal of Translational Medicine 2021 19:522
    Content type: Research Published on:

  17. Bullous pemphigoid (BP) is the most common autoimmune bullous skin disease that affects primarily patients older than 60 years. The majority of BP cases are spontaneous, but BP can also be triggered by certain...

    Authors: Karim Chouchane, Giovanni Di Zenzo, Dario Pitocco, Laura Calabrese and Clara De Simone
    Citation: Journal of Translational Medicine 2021 19:520
    Content type: Review Published on:

  18. Over the past decade, human Interleukin 33 (hIL-33) has emerged as a key contributor to the pathogenesis of numerous inflammatory diseases. Despite the existence of several commercial hIL-33 assays spanning mu...

    Authors: Elaine Mai, Joyce Chan, Levina Goon, Braeden K. Ego, Jack Bevers, Tiffany Wong, Manda Wong, Racquel Corpuz, Hongkang Xi, Jia Wu, Kellen Schneider, Dhaya Seshasayee, Michele Grimbaldeston, Gerald Nakamura, Vahan B. Indjeian, Menno van Lookeren Campagne…
    Citation: Journal of Translational Medicine 2021 19:517
    Content type: Methodology Published on:

  19. The development of Bruton’s tyrosine kinase inhibitors (BTKi) for the treatment of chronic lymphocytic leukaemia (CLL) has provided a highly effective and relatively non-toxic alternative to conventional chemo...

    Authors: Joanne E. Davis, Chia Sharpe, Kylie Mason, Constantine S. Tam, Rachel M. Koldej and David S. Ritchie
    Citation: Journal of Translational Medicine 2021 19:473
    Content type: Research Published on:

  20. Toll-like receptors (TLRs) on neutrophils play a crucial role in detecting pathogens and organ/tissue injury in acute-on-chronic liver failure (ACLF). However, little is known about the exact mechanisms and po...

    Authors: Yi Zhang, Wei Wu, Yijie Wang, Lingjia Tong, Meng Hong, Qi Xia and Zhi Chen
    Citation: Journal of Translational Medicine 2021 19:465
    Content type: Research Published on:

  21. Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patient...

    Authors: Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee and Hae-Rim Kim
    Citation: Journal of Translational Medicine 2021 19:392
    Content type: Research Published on:

  22. Neuroinflammation has been proved to play a role in dopaminergic neuronal death in Parkinson’s disease (PD). This link highlights the relevance of the immune response in the progression of the disease. However...

    Authors: Diana D. Álvarez-Luquín, Adrián Guevara-Salinas, Asiel Arce-Sillas, Raquel Espinosa-Cárdenas, Jaquelín Leyva-Hernández, Esteban U. Montes-Moratilla and Laura Adalid-Peralta
    Citation: Journal of Translational Medicine 2021 19:378
    Content type: Research Published on:

  23. Immune cells in the tumor microenvironment have prognostic value. In preclinical models, recruitment and infiltration of these cells depends on immune cell homing (ICH) genes such as chemokines, cell adhesion ...

    Authors: Minyoung Kwak, Gulsun Erdag, Katie M. Leick, Stefan Bekiranov, Victor H. Engelhard and Craig L. Slingluff
    Citation: Journal of Translational Medicine 2021 19:371
    Content type: Research Published on:

  24. Systemic lupus erythematosus (SLE) is an autoimmune disease with a complicated pathogenesis, and its aetiology has not been clearly unveiled. The lack of effective diagnosis and treatment methods makes it nece...

    Authors: Wencong Song, Jie Qiu, Lianghong Yin, Xiaoping Hong, Weier Dai, Donge Tang, Dongzhou Liu and Yong Dai
    Citation: Journal of Translational Medicine 2021 19:362
    Content type: Research Published on:

  25. Silicosis is one of the most common occupational pulmonary fibrosis caused by respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a commonly used biguanide antidiabetic agent,...

    Authors: Demin Cheng, Qi Xu, Yue Wang, Guanru Li, Wenqing Sun, Dongyu Ma, Siyun Zhou, Yi Liu, Lei Han and Chunhui Ni
    Citation: Journal of Translational Medicine 2021 19:349
    Content type: Research Published on:

  26. Kidney transplantation is an optimal method for treatment of end-stage kidney failure. However, kidney transplant rejection (KTR) is commonly observed to have negative effects on allograft function. MicroRNAs ...

    Authors: Yuxin Lin, Liangliang Wang, Wenqing Ge, Yu Hui, Zheng Zhou, Linkun Hu, Hao Pan, Yuhua Huang and Bairong Shen
    Citation: Journal of Translational Medicine 2021 19:346
    Content type: Research Published on:

  27. We tried to elaborate the molecular mechanism of ETS-like transcription factor 4 (ELK4) affecting gastric cancer (GC) progression through M2 polarization of macrophages mediated by lysine-specific demethylase ...

    Authors: Lei Zheng, Hongmei Xu, Ya Di, Lanlan Chen, Jiao Liu, Liying Kang and Liming Gao
    Citation: Journal of Translational Medicine 2021 19:342
    Content type: Research Published on:

  28. Biomarkers for distinguishing psoriatic arthritis (PsA) from psoriasis without arthritis (PsO) are still lacking.

    Authors: Jie Zhu, Ling Han, Ruilai Liu, Zhenghua Zhang, Qiong Huang, Xu Fang, Ke Yang, Guiqin Huang, Zhizhong Zheng, Nikhil Yawalkar, Hui Deng and Kexiang Yan
    Citation: Journal of Translational Medicine 2021 19:331
    Content type: Research Published on:

  29. Tumor microenvironment (TME) is associated with tumor progression and prognosis. Previous studies provided tools to estimate immune and stromal cell infiltration in TME. However, there is still a lack of singl...

    Authors: Zihang Zeng, Jiali Li, Jianguo Zhang, Yangyi Li, Xingyu Liu, Jiarui Chen, Zhengrong Huang, Qiuji Wu, Yan Gong and Conghua Xie
    Citation: Journal of Translational Medicine 2021 19:330
    Content type: Research Published on:

  30. Accumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs in CD4+ T cells from patients with systemic lupus er...

    Authors: Guannan Geng, Huijing Wang, Weiwei Xin, Zhe Liu, Jie Chen, Zhang Danting, Fei Han and Shuang Ye
    Citation: Journal of Translational Medicine 2021 19:305
    Content type: Research Published on:

  31. Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity I...

    Authors: Hui-Na Wang, Kunmei Ji, Li-Na Zhang, Chu-Chu Xie, Wei-Yong Li, Zhen-Fu Zhao and Jia-Jie Chen
    Citation: Journal of Translational Medicine 2021 19:261
    Content type: Research Published on:

  32. Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this ...

    Authors: Wendi Wei, Weida Chen and Naifeng He
    Citation: Journal of Translational Medicine 2021 19:258
    Content type: Research Published on:

  33. Recent studies reporting the intricate crosstalk between cellular and molecular mediators and the lymphatic endothelium in the development of inflammatory bowel diseases (IBD) suggest altered inflammatory cell...

    Authors: Dickson Kofi Wiredu Ocansey, Bing Pei, Xinwei Xu, Lu Zhang, Chinasa Valerie Olovo and Fei Mao
    Citation: Journal of Translational Medicine 2021 19:254
    Content type: Review Published on:

  34. N6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human dise...

    Authors: Chang Liu, Zhe Yang, Rong Li, Yanju Wu, Ming Chi, Shuting Gao, Xun Sun, Xin Meng and Biao Wang
    Citation: Journal of Translational Medicine 2021 19:251
    Content type: Review Published on:

  35. Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder of the gastrointestinal tract and comprises ulcerative colitis (UC) and Crohn’s disease (CD). Crohn’s disease can affect any p...

    Authors: Ilkyu Park, Jaeeun Jung, Sugi Lee, Kunhyang Park, Jea-Woon Ryu, Mi-Young Son, Hyun-Soo Cho and Dae-Soo Kim
    Citation: Journal of Translational Medicine 2021 19:250
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:329

  36. Programmed cell death ligand-1 (PD-L1) expression is a promising biomarker for identifying treatment related to non-small cell lung cancer (NSCLC). Automated image analysis served as an aided PD-L1 scoring too...

    Authors: Boju Pan, Yuxin Kang, Yan Jin, Lin Yang, Yushuang Zheng, Lei Cui, Jian Sun, Jun Feng, Yuan Li, Lingchuan Guo and Zhiyong Liang
    Citation: Journal of Translational Medicine 2021 19:249
    Content type: Research Published on:

  37. Recently, increased interleukin (IL)-24 expression has been demonstrated in the colon biopsies of adult patients with inflammatory bowel disease (IBD). However, the role of IL-24 in the pathomechanism of IBD i...

    Authors: Anna Ónody, Apor Veres-Székely, Domonkos Pap, Réka Rokonay, Beáta Szebeni, Erna Sziksz, Franz Oswald, Gábor Veres, Áron Cseh, Attila J. Szabó and Ádám Vannay
    Citation: Journal of Translational Medicine 2021 19:237
    Content type: Research Published on:

  38. The main limitation of current immune checkpoint inhibitors (ICIs) in the treatment of cervical cancer comes from the fact that it benefits only a minority of patients. The study aims to develop a classificati...

    Authors: Yimin Li, Shun Lu, Shubin Wang, Xinhao Peng and Jinyi Lang
    Citation: Journal of Translational Medicine 2021 19:222
    Content type: Research Published on:

  39. The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between the gut and brain, and is increasingly recognized as playing a central role in physiology and disease. MicroRNAs are import...

    Authors: Liang Zhao, Yingze Ye, Lijuan Gu, Zhihong Jian, Creed M. Stary and Xiaoxing Xiong
    Citation: Journal of Translational Medicine 2021 19:202
    Content type: Review Published on:

  40. Scleroderma is an autoimmune disease that causes dermal fibrosis. It occurs when collagen accumulates in tissue as a result of persistent inflammation. Th17 cells and pro-inflammatory cytokines such as IL-1β,...

    Authors: Jeonghyeon Moon, Seon-yeong Lee, Jeong Won Choi, A Ram Lee, Jin Hee Yoo, Su-Jin Moon, Sung-Hwan Park and Mi-La Cho
    Citation: Journal of Translational Medicine 2021 19:192
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:266

  41. T cells and B cells play a key role in alloimmune responses. We aimed to characterize the shift of T cell subsets and B cell subsets during acute hepatic rejection, and further determine whether they could ser...

    Authors: Ji-Qiao Zhu, Jing Wang, Xian-Liang Li, Wen-Li Xu, Shao-cheng Lv, Xin Zhao, Ren Lang and Qiang He
    Citation: Journal of Translational Medicine 2021 19:187
    Content type: Research Published on:

  42. New medications for Rheumatoid Arthritis (RA) have emerged in the last decades, including Disease Modifying Antirheumatic Drugs (DMARDs) and biologics. However, there is no known cure, since a significant prop...

    Authors: Lydia Ntari, Christoforos Nikolaou, Ksanthi Kranidioti, Dimitra Papadopoulou, Eleni Christodoulou-Vafeiadou, Panagiotis Chouvardas, Florian Meier, Christina Geka, Maria C. Denis, Niki Karagianni and George Kollias
    Citation: Journal of Translational Medicine 2021 19:165
    Content type: Research Published on:

  43. Osteoarthritis (OA) is a disease of the entire joint involving synovial fibrosis and inflammation. Pathological changes to the synovium can accelerate the progression of OA. Pirfenidone (PFD) is a potent anti-...

    Authors: Qilu Wei, Ning Kong, Xiaohui Liu, Run Tian, Ming Jiao, Yiyang Li, Huanshuai Guan, Kunzheng Wang and Pei Yang
    Citation: Journal of Translational Medicine 2021 19:157
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:434

  44. Modification of the gut microbiota by antibiotics may influence the disease susceptibility and immunological responses. Infants in the neonatal intensive care unit (NICU) subjected to frequent antibiotics and ...

    Authors: Xiao Ran, Yu He, Qing Ai and Yuan Shi
    Citation: Journal of Translational Medicine 2021 19:155
    Content type: Research Published on:

  45. Lung cancer is the most common cancer and cause of cancer‐related mortality worldwide, increasing evidence indicated that there was a significant correlation between tumors and the long non‐coding RNAs (lncRNA...

    Authors: Lan Mu, Ke Ding, Ranran Tu and Wei Yang
    Citation: Journal of Translational Medicine 2021 19:127
    Content type: Research Published on:

  47. Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induces uncontrolled and self-amplified pulmonary inflammation, and has high morbidity and mortality rates in critically ill patients. In rece...

    Authors: Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv and Wei Han
    Citation: Journal of Translational Medicine 2021 19:96
    Content type: Research Published on:

  48. Regimens combining pemetrexed (PEM) and immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1) or programmed death-ligand 1 (PD-L1) are widely used for the treatment of advanced non-squam...

    Authors: Issei Sumiyoshi, Takahiro Okabe, Shinsaku Togo, Haruhi Takagi, Hiroaki Motomura, Yusuke Ochi, Naoko Shimada, Mizuki Haraguchi, Rina Shibayama, Yuichi Fujimoto, Junko Watanabe, Moe Iwai, Kotaro Kadoya, Shin-ichiro Iwakami and Kazuhisa Takahashi
    Citation: Journal of Translational Medicine 2021 19:92
    Content type: Research Published on:

  49. Autoantibody production against endogenous cellular components is pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (TFH) cells aid in B cell differentiation into autoantibody-producin...

    Authors: Se Gwang Jang, Jaeseon Lee, Seung-Min Hong, Young-Seok Song, Min Jun Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2021 19:86
    Content type: Research Published on:

  50. Systemic lupus erythematosus (SLE) is a multisystemic, chronic inflammatory disease characterized by destructive systemic organ involvement, which could cause the decreased functional capacity, increased morbi...

    Authors: Xingwang Zhao, Longlong Zhang, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni and Yi You
    Citation: Journal of Translational Medicine 2021 19:35
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:64

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