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Immunobiology and immunotherapy

Section edited by Alessandra Cesano

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. Lung cancer is the most common cancer and cause of cancer‐related mortality worldwide, increasing evidence indicated that there was a significant correlation between tumors and the long non‐coding RNAs (lncRNA...

    Authors: Lan Mu, Ke Ding, Ranran Tu and Wei Yang
    Citation: Journal of Translational Medicine 2021 19:127
  2. Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induces uncontrolled and self-amplified pulmonary inflammation, and has high morbidity and mortality rates in critically ill patients. In rece...

    Authors: Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv and Wei Han
    Citation: Journal of Translational Medicine 2021 19:96
  3. Regimens combining pemetrexed (PEM) and immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1) or programmed death-ligand 1 (PD-L1) are widely used for the treatment of advanced non-squam...

    Authors: Issei Sumiyoshi, Takahiro Okabe, Shinsaku Togo, Haruhi Takagi, Hiroaki Motomura, Yusuke Ochi, Naoko Shimada, Mizuki Haraguchi, Rina Shibayama, Yuichi Fujimoto, Junko Watanabe, Moe Iwai, Kotaro Kadoya, Shin-ichiro Iwakami and Kazuhisa Takahashi
    Citation: Journal of Translational Medicine 2021 19:92
  4. Autoantibody production against endogenous cellular components is pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (TFH) cells aid in B cell differentiation into autoantibody-producin...

    Authors: Se Gwang Jang, Jaeseon Lee, Seung-Min Hong, Young-Seok Song, Min Jun Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2021 19:86
  5. Systemic lupus erythematosus (SLE) is a multisystemic, chronic inflammatory disease characterized by destructive systemic organ involvement, which could cause the decreased functional capacity, increased morbi...

    Authors: Xingwang Zhao, Longlong Zhang, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni and Yi You
    Citation: Journal of Translational Medicine 2021 19:35

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:64

  6. Although the tumour immune microenvironment is known to significantly influence immunotherapy outcomes, its association with changes in gene expression patterns in hepatocellular carcinoma (HCC) during immunot...

    Authors: Xinyu Gu, Jun Guan, Jia Xu, Qiuxian Zheng, Chao Chen, Qin Yang, Chunhong Huang, Gang Wang, Haibo Zhou, Zhi Chen and Haihong Zhu
    Citation: Journal of Translational Medicine 2021 19:26
  7. Immune checkpoint inhibitors (ICIs) have become a frontier in the field of clinical technology for advanced non-small cell lung cancer (NSCLC). Currently, the predictive biomarker of ICIs mainly including the ...

    Authors: Li Wang, Zhixuan Ren, Bentong Yu and Jian Tang
    Citation: Journal of Translational Medicine 2021 19:22
  8. Metabolic cell features are able to give reliable information on cell functional state. Thus, metabolic potential assessment of T cells in malignancy setting represents a promising area, especially in adoptive...

    Authors: Patricia Mercier-Letondal, Chrystel Marton, Yann Godet and Jeanne Galaine
    Citation: Journal of Translational Medicine 2021 19:21
  9. Rheumatoid arthritis (RA) is the most common chronic autoimmune connective tissue disease. However, early RA is difficult to diagnose due to the lack of effective biomarkers. This study aimed to identify new b...

    Authors: Qi Cheng, Xin Chen, Huaxiang Wu and Yan Du
    Citation: Journal of Translational Medicine 2021 19:18
  10. Inflammatory disorders like diabetes, systemic lupus erythematodes, inflammatory lung diseases, rheumatoid arthritis and multiple sclerosis, but also rejection of transplanted organs and GvHD, form a major bur...

    Authors: Sija Landman, Chiel van der Horst, Piet E. J. van Erp, Irma Joosten, Rob de Vries and Hans J. P. M. Koenen
    Citation: Journal of Translational Medicine 2021 19:11
  11. Ankylosing spondylitis (AS) is characterized by excessive production of inflammatory cytokines. Recent evidence suggests that inflammation underlies the neurodegenerative process of Parkinson’s disease (PD). W...

    Authors: Fu-Chiang Yeh, Hsiang-Cheng Chen, Yu-Ching Chou, Cheng-Li Lin, Chia-Hung Kao, Hsin-Yi Lo, Feng-Cheng Liu and Tse-Yen Yang
    Citation: Journal of Translational Medicine 2020 18:455
  12. Dysregulation of transcription and cytokine expression has been implicated in the pathogenesis of a variety inflammatory diseases. The resulting imbalance between inflammatory and resolving transcriptional pro...

    Authors: Gregory Thomas, Elizabeth Frederick, Lisa Thompson, Raphael Bar-Or, Yetti Mulugeta, Melissa Hausburg, Michael Roshon, Charles Mains and David Bar-Or
    Citation: Journal of Translational Medicine 2020 18:452
  13. Thymocyte-expressed, positive selection-associated 1 (Tespa1) is a critical signaling molecule in thymocyte development. This study aimed to investigate the regulatory effect of Tespa1 on mast cells in the pat...

    Authors: Ruhui Yang, Guangli Wang, Lingyun Li, Hanjiang He, Mingzhu Zheng, Linrong Lu and Songquan Wu
    Citation: Journal of Translational Medicine 2020 18:444
  14. Immunity reaction plays an essential role in periodontitis progress and we aim to investigate the underlying regulatory network of immune reactions in periodontitis.

    Authors: Xiaoqi Zhang, Qingxuan Wang, Xinyu Yan, Yue Shan, Lu Xing, Minqi Li, Hu Long and Wenli Lai
    Citation: Journal of Translational Medicine 2020 18:438
  15. Neutrophil extracellular traps (NETs) from patients with systemic lupus erythematosus (SLE) are characterized by lower ubiquitylation and myeloperoxidase (MPO) as a substrate. The structural and functional eff...

    Authors: Daniel Alberto Carrillo-Vázquez, Eduardo Jardón-Valadez, Jiram Torres-Ruiz, Guillermo Juárez-Vega, José Luis Maravillas-Montero, David Eduardo Meza-Sánchez, María Lilia Domínguez-López, Jorge Carlos Alcocer Varela and Diana Gómez-Martín
    Citation: Journal of Translational Medicine 2020 18:429
  16. Foxp3+ regulatory T cells (Tregs) play essential roles in immune homeostasis and repair of damaged lung tissue. We hypothesized that patients whose lung injury resolves quickly, as measured by time to liberation ...

    Authors: Dustin L. Norton, Agathe Ceppe, Miriya K. Tune, Matthew McCravy, Thomas Devlin, M. Bradley Drummond, Shannon S. Carson, Benjamin G. Vincent, Robert S. Hagan, Hong Dang, Claire M. Doerschuk and Jason R. Mock
    Citation: Journal of Translational Medicine 2020 18:427
  17. Numerous tissue-derived factors have been postulated to be involved in tissue migration of circulating monocytes. The aim of this study was to evaluate whether a defined hypoxic gradient can induce directed mi...

    Authors: Lars Hummitzsch, Rouven Berndt, Matthias Kott, Rene Rusch, Fred Faendrich, Matthias Gruenewald, Markus Steinfath, Martin Albrecht and Karina Zitta
    Citation: Journal of Translational Medicine 2020 18:404
  18. In Crohn’s disease (CD), one of the major inflammatory bowel disease (IBD) in human beings, there is over-expression of Smad7, an intracellular inhibitor of the suppressive cytokine TGF-β1. The aim of this stu...

    Authors: Francesca Zorzi, Emma Calabrese, Davide Di Fusco, Elena De Cristofaro, Livia Biancone, Sara Casella, Giampiero Palmieri and Giovanni Monteleone
    Citation: Journal of Translational Medicine 2020 18:395
  19. Rheumatoid arthritis (RA) and periodontitis (PD) are proven to share common risk markers, including genetic factors. In the present study we focused on genetic variants in PTPN22 (rs2476601), PADI4 (rs2240340), C...

    Authors: Susanne Schulz, Pauline Zimmer, Natalie Pütz, Elisa Jurianz, Hans-Günter Schaller and Stefan Reichert
    Citation: Journal of Translational Medicine 2020 18:389
  20. Autoimmune hepatitis (AIH) is a liver disease characterized by the autoimmune-induced injury of hepatocytes which can lead to cirrhosis and hepatic failure. The diagnosis and disease management of AIH patients...

    Authors: Rui Wu, Yan Liu, Ruyu Yan, Xiaoyu Liu and Liang Duan
    Citation: Journal of Translational Medicine 2020 18:384
  21. The study of localized immune-related factors has proven beneficial for a variety of conditions, and one area of interest in the field of orthopaedics is the impact of implants and localized infections on immu...

    Authors: Nicole Prince, Julia A. Penatzer, Matthew J. Dietz and Jonathan W. Boyd
    Citation: Journal of Translational Medicine 2020 18:330
  22. To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells.

    Authors: Jooyeon Jhun, Hong Ki Min, Jaeyoon Ryu, Seon-Yeong Lee, Jun-Geol Ryu, Jeong Won Choi, Hyun Sik Na, Seung Yoon Lee, Yunju Jung, Sang-Jun Park, Myeong Soo Park, Bin Kwon, Geun Eog Ji, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2020 18:317
  23. Fibrinogen-like protein 1 (FGL1)—Lymphocyte activating gene 3 (LAG-3) pathway is a promising immunotherapeutic target and has synergistic effect with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1)...

    Authors: Mengzhou Guo, Feifei Yuan, Feng Qi, Jialei Sun, Qianwen Rao, Zhiying Zhao, Peixin Huang, Tingting Fang, Biwei Yang and Jinglin Xia
    Citation: Journal of Translational Medicine 2020 18:306
  24. Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their cl...

    Authors: Hyun Sik Na, Seon-yeong Lee, Hong Ki Min, Wan-je Park, Jung-hwan Lee, Ka-hee Cho, Shin-hee Hong, Dae-hoon Kim, Jooyeon Jhun, Jeong-Won Choi, Sung-Min Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2020 18:264
  25. Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansio...

    Authors: Adam Brufsky, Juan Luis Gomez Marti, Azadeh Nasrazadani and Michael T. Lotze
    Citation: Journal of Translational Medicine 2020 18:261
  26. Pools of overlapping synthetic peptides are routinely used for ex vivo monitoring of antigen-specific T-cell responses. However, it is rather unlikely that these peptides match those resulting from naturally p...

    Authors: Nina Körber, Uta Behrends, Ulrike Protzer and Tanja Bauer
    Citation: Journal of Translational Medicine 2020 18:242
  27. Fibrosis is the formation of excess connective tissue in an organ or tissue during a reparative or reactive process. Graft-versus-host disease (GvHD) is a medical complication of allogeneic tissue transplantat...

    Authors: Jaeyoon Ryu, Jooyeon Jhun, Min-Jung Park, Jin-ah Baek, Se-Young Kim, Keun-Hyung Cho, Jeong-Won Choi, Sung-Hwan Park, Jong Young Choi and Mi-La Cho
    Citation: Journal of Translational Medicine 2020 18:225
  28. During early pregnancy, tolerance of the semi-allogeneic fetus necessitates comprehensive modifications of the maternal immune system. How decidual CD8+T (CD8+dT) cells balance maternal tolerance of the fetus wit...

    Authors: Lu Liu, Xixi Huang, Chunfang Xu, Chunqin Chen, Weijie Zhao, Dajin Li, Liping Li, Li Wang and Meirong Du
    Citation: Journal of Translational Medicine 2020 18:221
  29. Previous studies have shown clinical relevance of programmed death-ligand 1 (PD-L1) and soluble PD-L1 (sPD-L1) in human cancers. However, still contradictory results exist. Our aim was evaluation of PD-L1-expr...

    Authors: Karolina Okła, Alicja Rajtak, Arkadiusz Czerwonka, Marcin Bobiński, Anna Wawruszak, Rafał Tarkowski, Wiesława Bednarek, Justyna Szumiło and Jan Kotarski
    Citation: Journal of Translational Medicine 2020 18:220

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:258

  30. Patients with critical illness due to infection with the 2019 coronavirus disease (COVID-19) show rapid disease progression to acute respiratory failure. The study aimed to screen the most useful predictive fa...

    Authors: Jingyuan Liu, Yao Liu, Pan Xiang, Lin Pu, Haofeng Xiong, Chuansheng Li, Ming Zhang, Jianbo Tan, Yanli Xu, Rui Song, Meihua Song, Lin Wang, Wei Zhang, Bing Han, Li Yang, Xiaojing Wang…
    Citation: Journal of Translational Medicine 2020 18:206
  31. Sjögren’s syndrome (SS) is an autoimmune disease mediated by lymphocytic infiltration into exocrine glands, resulting in progressive lacrimal and salivary destruction and dysfunctional glandular secretion. Met...

    Authors: Sun-Hee Hwang, Jin-Sil Park, SeungCheon Yang, Kyung-Ah Jung, JeongWon Choi, Seung-Ki Kwok, Sung-Hwan Park and Mi-La Cho
    Citation: Journal of Translational Medicine 2020 18:186
  32. In a randomized phase II trial conducted in patients with metastatic melanoma, patient-specific autologous dendritic cell vaccines (DCV) were associated with longer survival than autologous tumor cell vaccines...

    Authors: Gabriel I. Nistor and Robert O. Dillman
    Citation: Journal of Translational Medicine 2020 18:176
  33. The mechanisms underlying the therapeutic activity of interferon-β in multiple sclerosis are still not completely understood. In the present study, we evaluated the short and long-term effects of interferon-β ...

    Authors: Marco Chiarini, Ruggero Capra, Federico Serana, Diego Bertoli, Alessandra Sottini, Viviana Giustini, Cristina Scarpazza, Marco Rovaris, Valentina Torri Clerici, Diana Ferraro, Simonetta Galgani, Claudio Solaro, Marta Zaffira Conti, Andrea Visconti and Luisa Imberti
    Citation: Journal of Translational Medicine 2020 18:169
  34. Complement Regulatory Proteins (CRPs), especially CD55 primarily negate complement factor 3-mediated injuries and maintain tissue homeostasis during complement cascade activation. Complement activation and reg...

    Authors: Mohammad Afzal Khan, Talal Shamma, Shadab Kazmi, Abdullah Altuhami, Hala Abdalrahman Ahmed, Abdullah Mohammed Assiri and Dieter Clemens Broering
    Citation: Journal of Translational Medicine 2020 18:147
  35. Cancer Immunotherapy has recently emerged as a promising and effective modality to treat different malignancies. Antigenic profiling of cancer tissues and determination of any pre-existing immune responses to ...

    Authors: Afsheen Raza, Maysaloun Merhi, Varghese Philipose Inchakalody, Roopesh Krishnankutty, Allan Relecom, Shahab Uddin and Said Dermime
    Citation: Journal of Translational Medicine 2020 18:140
  36. Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by an alteration in airway epithelial cell functions including barrier function, wound repair mechanisms, mucociliary clearance. The mechanism...

    Authors: Emilie Bequignon, David Mangin, Justine Bécaud, Jennifer Pasquier, Christelle Angely, Mathieu Bottier, Estelle Escudier, Daniel Isabey, Marcel Filoche, Bruno Louis, Jean-François Papon and André Coste
    Citation: Journal of Translational Medicine 2020 18:136
  37. Transitional B cells (TrB cells) represent a crucial link between immature B cells in the bone marrow and mature peripheral B cells. Although TrB cells represent one of the regulatory B cell subpopulations in ...

    Authors: Yang Zhou, Ying Zhang, Jinming Han, Mengge Yang, Jie Zhu and Tao Jin
    Citation: Journal of Translational Medicine 2020 18:131
  38. PD-1 blocking agents, such as nivolumab, have demonstrated clear anti-tumor effects and clinical benefits in a subset of patients with advanced malignancies. Nonetheless, more efforts are needed to identify re...

    Authors: Mariaelena Capone, Federica Fratangelo, Diana Giannarelli, Claudia Sorrentino, Roberta Turiello, Serena Zanotta, Domenico Galati, Gabriele Madonna, Marilena Tuffanelli, Luigi Scarpato, Antonio M. Grimaldi, Assunta Esposito, Rosa Azzaro, Antonio Pinto, Ernesta Cavalcanti, Aldo Pinto…
    Citation: Journal of Translational Medicine 2020 18:121
  39. Lung adenocarcinoma (LUAD) is the most frequent subtype of lung cancer. The prognostic signature could be reliable to stratify LUAD patients according to risk, which helps the management of the systematic trea...

    Authors: Dina Guo, Mian Wang, Zhihong Shen and Jiaona Zhu
    Citation: Journal of Translational Medicine 2020 18:123
  40. Salmonella enterica serovar Typhi (S. Typhi) is a highly invasive bacterium that infects the human intestinal mucosa and causes ~ 11.9–20.6 million infections and ~ 130,000–223,000 deaths annually worldwide. Oral...

    Authors: Jayaum S. Booth, Eric Goldberg, Robin S. Barnes, Bruce D. Greenwald and Marcelo B. Sztein
    Citation: Journal of Translational Medicine 2020 18:102
  41. Macrophages are heterogenous phagocytic cells with an important role in the innate immunity. They are, also, significant contributors in the adaptive immune system. Macrophages are the most abundant immune cel...

    Authors: Mohamed Hamed Abdelaziz, Sayed F. Abdelwahab, Jie Wan, Wei Cai, Wang Huixuan, Cheng Jianjun, Kesavan Dinesh Kumar, Aparna Vasudevan, Ahmed Sadek, Zhaoliang Su, Shengjun Wang and Huaxi Xu
    Citation: Journal of Translational Medicine 2020 18:58
  42. Crohn’s disease (CD) is a multifactorial disease characterized by chronic intestinal inflammation. The increased visceral adiposity near the affected intestinal area, of which mesenteric adipose tissue (MAT) i...

    Authors: Francesca Aparecida Ramos da Silva, Lívia Bitencourt Pascoal, Isabella Dotti, Maria de Lourdes Setsuko Ayrizono, Daniel Aguilar, Bruno Lima Rodrigues, Montserrat Arroyes, Elena Ferrer-Picon, Marciane Milanski, Lício Augusto Velloso, João José Fagundes, Azucena Salas and Raquel Franco Leal
    Citation: Journal of Translational Medicine 2020 18:44
  43. Recently, involvement of IL-19, IL-20 and IL-24 has been reported in inflammatory diseases associated with tissue remodeling. However, their impact on the pathomechanism of coeliac disease (CD) is still comple...

    Authors: Réka Rokonay, Apor Veres-Székely, Beáta Szebeni, Domonkos Pap, Rita Lippai, Nóra J. Béres, Gábor Veres, Attila J. Szabó and Ádám Vannay
    Citation: Journal of Translational Medicine 2020 18:36
  44. We have previously shown that HCC patients and healthy subjects are equally responsive to a RNAdjuvant®, a novel TLR-7/8/RIG-I agonist based on noncoding RNA developed by CureVac, by an ex vivo evaluation. Howeve...

    Authors: Angela Mauriello, Carmen Manolio, Beatrice Cavalluzzo, Antonio Avallone, Marco Borrelli, Alessandro Morabito, Emanuele Iovine, Angela Chambery, Rosita Russo, Maria Lina Tornesello, Franco M. Buonaguro, Maria Tagliamonte and Luigi Buonaguro
    Citation: Journal of Translational Medicine 2020 18:34
  45. The inefficacy of standard therapeutic strategies for ovarian cancer is reflected by the enduring poor prognosis of this malignancy. Due to the potential for exquisite specificity, sensitivity and long-term me...

    Authors: Leonardo Mirandola, Maurizio Chiriva-Internati, Robert Bresalier, Lucia Piccotti, Fabio Grizzi and Francesco M. Marincola
    Citation: Journal of Translational Medicine 2019 17:424
  46. Inflammatory Bowel Disease (IBD) is a multifactorial chronic disease. Understanding only one aspect of IBD pathogenesis does not reflect the complex nature of IBD nor will it improve its clinical management. T...

    Authors: Manoj Kumar, Mathieu Garand and Souhaila Al Khodor
    Citation: Journal of Translational Medicine 2019 17:419
  47. Immunosuppression caused by tumorigenesis may promote tumor progress and invasion. Here, we investigated whether the characteristics of circulating T lymphocyte subtypes in patients with extensive small cell l...

    Authors: Ning An, Haoyi Wang, Wenxiao Jia, Wang Jing, Chao Liu, Hui Zhu and Jinming Yu
    Citation: Journal of Translational Medicine 2019 17:402

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