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Immunobiology and immunotherapy

Section edited by Alessandra Cesano

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. Content type: Research

    Due to their self-renewal capacity, multi-lineage potential, and immunomodulatory properties, mesenchymal stromal cells (MSCs) are an attractive tool for different therapeutic strategies. Foreskin (FSK), consi...

    Authors: Hussein Fayyad-Kazan, Mohammad Fayyad-Kazan, Bassam Badran, Dominique Bron, Laurence Lagneaux and Mehdi Najar

    Citation: Journal of Translational Medicine 2017 15:10

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  2. Content type: Research

    Prophylactic and therapeutic vaccines often depend upon a strong activation of the innate immune system to drive a potent adaptive immune response, often mediated by a strong adjuvant. For a number of adjuvant...

    Authors: Darin K. Edwards, Edith Jasny, Heesik Yoon, Nigel Horscroft, Brian Schanen, Tanya Geter, Mariola Fotin-Mleczek, Benjamin Petsch and Vaughan Wittman

    Citation: Journal of Translational Medicine 2017 15:1

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  3. Content type: Research

    The mechanisms by which vaccinia virus (VACV) interacts with the innate immune components are complex and involve different mechanisms. iNOS-mediated NO production by myeloid cells is one of the central antivi...

    Authors: Mehmet Okyay Kilinc, Klaas Ehrig, Maysam Pessian, Boris R. Minev and Aladar A. Szalay

    Citation: Journal of Translational Medicine 2016 14:340

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  4. Content type: Research

    An infection-immune association of periodontal disease with rheumatoid arthritis has been suggested. This study aimed to investigate the effect of pre-existing periodontitis on the development and the immune/i...

    Authors: Kaja Eriksson, Erik Lönnblom, Gregory Tour, Anna Kats, Piotr Mydel, Pierre Georgsson, Catharina Hultgren, Nastya Kharlamova, Ulrika Norin, Jörgen Jönsson, Anna Lundmark, Annelie Hellvard, Karin Lundberg, Leif Jansson, Rikard Holmdahl and Tülay Yucel-Lindberg

    Citation: Journal of Translational Medicine 2016 14:311

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  5. Content type: Research

    Chemokines and chemokine receptors play important roles in autoimmune diseases; however, their role in immune thrombocytopenia (ITP) is unclear. High-dose dexamethasone (HD-DXM) may become a first-line therapy...

    Authors: Zongtang Liu, Meiying Wang, Shufen Zhou, Ji Ma, Yan Shi, Jun Peng, Ming Hou and Chengshan Guo

    Citation: Journal of Translational Medicine 2016 14:301

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  6. Content type: Research

    Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Efficient antiviral T-cell responses are necessary to clear infect...

    Authors: Sabine Tischer, René Geyeregger, Julian Kwoczek, Albert Heim, Constanca Figueiredo, Rainer Blasczyk, Britta Maecker-Kolhoff and Britta Eiz-Vesper

    Citation: Journal of Translational Medicine 2016 14:286

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  7. Content type: Research

    Cancer immunotherapy can be potentiated by conditioning regimens such as cyclophosphamide, which reduces the level of regulatory T cells (tregs). However, myeloid suppressive cells are still remaining. Accordi...

    Authors: Emma Eriksson, Jessica Wenthe, Sandra Irenaeus, Angelica Loskog and Gustav Ullenhag

    Citation: Journal of Translational Medicine 2016 14:282

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  8. Content type: Research

    Asthma is prone to Th2-mediated chronic airway inflammation. Interleukin-27 (IL-27) is a member of the IL-12 family that promotes the differentiation of Th1 cells and inhibits Th2 cells. We use human/mouse CD4+ T...

    Authors: Xiaoqiong Su, Jue Pan, Fengxi Bai, Honglei Yuan, Nian Dong, Dandan Li, Xiangdong Wang and Zhihong Chen

    Citation: Journal of Translational Medicine 2016 14:283

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  9. Content type: Research

    Cytokine-induced-killer (CIK) cells are a promising immunotherapeutic approach for impending relapse following hematopoietic stem cell transplantation (HSCT). However, there is a high risk for treatment failur...

    Authors: Melanie Bremm, Sabine Huenecke, Olga Zimmermann, Verena Pfirrmann, Andrea Quaiser, Halvard Bonig, Jan Soerensen, Thomas Klingebiel, Eva Rettinger, Peter Bader and Claudia Cappel

    Citation: Journal of Translational Medicine 2016 14:264

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  10. Content type: Research

    The Vk*MYC transgenic and transplant mouse models of multiple myeloma (MM) are well established as a research tool for anti-myeloma drug discovery. However, little is known of the immune response in these mode...

    Authors: Rachel E. Cooke, Nicholas A. Gherardin, Simon J. Harrison, Hang Quach, Dale I. Godfrey, Miles Prince, Rachel Koldej and David S. Ritchie

    Citation: Journal of Translational Medicine 2016 14:259

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  11. Content type: Research

    Tumour resistance to a wide range of drugs (multiple drug resistant, MDR) acquired after intensive chemotherapy is considered to be the main obstacle of the curative treatment of cancer patients. Recent work h...

    Authors: Elena P. Goncharova, Julia S. Ruzhenkova, Ivan S. Petrov, Sergey N. Shchelkunov and Marina A. Zenkova

    Citation: Journal of Translational Medicine 2016 14:241

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    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:280

  12. Content type: Review

    Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host’s health and disease. Gut microbiota in fact plays a crucial role in modulating innate an...

    Authors: Andrea Picchianti Diamanti, M. Manuela Rosado, Bruno Laganà and Raffaele D’Amelio

    Citation: Journal of Translational Medicine 2016 14:233

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  13. Content type: Research

    Epstein-Barr virus and Cytomegalovirus reactivations frequently occur after allogeneic stem cell transplantation (SCT).

    Authors: Julia Drylewicz, Ingrid M. M. Schellens, Rogier Gaiser, Nening M. Nanlohy, Esther D. Quakkelaar, Henny Otten, Suzanne van Dorp, Ronald Jacobi, Leonie Ran, Sanne Spijkers, Dan Koning, Rob Schuurman, Ellen Meijer, Floortje L. Pietersma, Jurgen Kuball and Debbie van Baarle

    Citation: Journal of Translational Medicine 2016 14:230

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  14. Content type: Research

    High-risk human papillomaviruses (HR-HPVs) types 16 and 18 are the main etiological agents of cervical cancer, with more than 550,000 new cases each year worldwide. HPVs are also associated with other ano-geni...

    Authors: Elena Illiano, Olivia Costantina Demurtas, Silvia Massa, Paola Di Bonito, Valerio Consalvi, Roberta Chiaraluce, Carlo Zanotto, Carlo De Giuli Morghen, Antonia Radaelli, Aldo Venuti and Rosella Franconi

    Citation: Journal of Translational Medicine 2016 14:224

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  15. Content type: Research

    Immunotherapy based on the adoptive transfer of gene modified T cells is an emerging approach for the induction of tumor-specific immune responses. Memory stem T cells, due to their enhanced antitumor and self...

    Authors: C. Alvarez-Fernández, L. Escribà-Garcia, S. Vidal, J. Sierra and J. Briones

    Citation: Journal of Translational Medicine 2016 14:214

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  16. Content type: Research

    T helper (Th) 17 cells are a subset of T helper cells that express interleukin (IL)-17 and initiate the inflammatory response in autoimmune diseases. Regulatory T cells (Tregs) are a subpopulation of T cells t...

    Authors: Min-Jung Park, Seung Hoon Lee, Sung-Hee Lee, Eun-Kyung Kim, Eun Jung Lee, Young-Mee Moon and Mi- La Cho

    Citation: Journal of Translational Medicine 2016 14:206

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  17. Content type: Research

    Foxp3 is a key regulator of the development and function of regulatory T cells (Tregs), and its expression is thought to be T cell-restricted. We found that B cells in mice can express Foxp3 and B cells expres...

    Authors: Mi Kyung Park, Young Ok Jung, Seon-Yeong Lee, Seung Hoon Lee, Yu Jung Heo, Eun Kyung Kim, Hye Jwa Oh, Young Mee Moon, Hye-Jin Son, Min Jung Park, Sung Hwan Park, Ho Youn Kim, Mi La Cho and Jun Ki Min

    Citation: Journal of Translational Medicine 2016 14:191

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    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:221

  18. Content type: Research

    Spondyloarthritis (SpA) usually manifests as arthritis of the axial and peripheral joints but can also result in extra-articular manifestations such as inflammatory bowel disease. Proinflammatory cytokine inte...

    Authors: Hong-Ki Min, Jae-Kyung Kim, Seon-Yeong Lee, Eun-Kyung Kim, Seung Hoon Lee, Jennifer Lee, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

    Citation: Journal of Translational Medicine 2016 14:190

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  19. Content type: Research

    TNF weakly inducer of apoptosis (TWEAK) is member of the TNF ligand superfamily. Various data support that TWEAK produced by synovial macrophages may contribute to synovitis observed in psoriatic arthritis (P...

    Authors: Sandrine Guis, Philippe Berbis, Delphine Stephan, Daniel Bertin, Florent Amatore, Nathalie Balandraud, Nathalie Lesavre and Sophie Desplat-Jégo

    Citation: Journal of Translational Medicine 2016 14:185

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  20. Content type: Research

    Exosomes are nano-sized extracellular vesicles participating in cell-to-cell communication both in health and disease. However, the knowledge about the functions and molecular composition of exosomes in the up...

    Authors: Cecilia Lässer, Serena E. O’Neil, Ganesh V. Shelke, Carina Sihlbom, Sara F. Hansson, Yong Song Gho, Bo Lundbäck and Jan Lötvall

    Citation: Journal of Translational Medicine 2016 14:181

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  21. Content type: Research

    Tuberculosis (TB) remains a major public health concern worldwide. Previous studies have demonstrated that IL-17 plays an important role in initial immune response and is involved in both immune-mediated prote...

    Authors: Lichen Xu, Guangying Cui, Hongyu Jia, Yunan Zhu, Yulong Ding, Jianing Chen, Chong Lu, Ping Ye, Hainv Gao, Lanjuan Li, Weihang Ma, Jianxin Lyu and Hongyan Diao

    Citation: Journal of Translational Medicine 2016 14:179

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  22. Content type: Research

    Organizing pneumonia is a reaction pattern and an inflammatory response to acute lung injuries, and is characterized by intraluminal plugs of granulation tissue in distal airspaces. In contrast to other fibrot...

    Authors: Nicole Izykowski, Mark Kuehnel, Kais Hussein, Kristin Mitschke, Michael Gunn, Sabina Janciauskiene, Axel Haverich, Gregor Warnecke, Florian Laenger, Ulrich Maus and Danny Jonigk

    Citation: Journal of Translational Medicine 2016 14:169

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  23. Content type: Research

    The risk for developing cardiovascular disease is greater in patients with rheumatoid arthritis (RA) than in the general population. While patients with RA also have dyslipidemia, the impact of dyslipidemia on...

    Authors: Amy M. Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V. Misharin, FuNien Tsai, G. Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E. Vaughan, Carla M. Cuda and Harris Perlman

    Citation: Journal of Translational Medicine 2016 14:170

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  24. Content type: Research

    Our previous results showed that intrasynovial Rifamycin SV caused the lysis of synoviocites and freed the autoantigens which in turn stimulated the immunoregulatory rather than autoreactive T cell response in...

    Authors: Innocenzo Caruso, Salvatore Santandrea, Mariarita Gismondo, Alessandra Lombardi, Franco Montrone, Enzo Massimo Caruso and Piercarlo Sarzi Puttini

    Citation: Journal of Translational Medicine 2016 14:162

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  25. Content type: Research

    NLRP3 inflammasome has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). The activation of NLRP3 inflammasome results in the production of IL-1β and the subsequent inflammation. Anti-d...

    Authors: Hui Zhang, Rong Fu, Chaohuan Guo, Yuefang Huang, Hongyue Wang, Shuang Wang, Jijun Zhao and Niansheng Yang

    Citation: Journal of Translational Medicine 2016 14:156

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  26. Content type: Research

    Noroviruses (NoVs) are a major cause of childhood gastroenteritis and foodborne diseases worldwide. Lack of appropriate animal models or cell-based culture systems makes the development and evaluation of NoV-s...

    Authors: Vivek Verma, Wenzhi Tan, Sao Puth, Kyoung-Oh Cho, Shee Eun Lee and Joon Haeng Rhee

    Citation: Journal of Translational Medicine 2016 14:135

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  27. Content type: Research

    Dendritic cells (DCs) rendered suppressive by treatment with mitomycin C and loaded with the autoantigen myelin basic protein demonstrated earlier their ability to prevent experimental autoimmune encephalomyel...

    Authors: Christian Kleist, Elisabeth Mohr, Sadanand Gaikwad, Laura Dittmar, Stefanie Kuerten, Michael Platten, Walter Mier, Michael Schmitt, Gerhard Opelz and Peter Terness

    Citation: Journal of Translational Medicine 2016 14:99

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  28. Content type: Research

    Chronic lymphocytic leukemia (CLL) remains incurable with standard therapy, and is characterized by excessive expansion of monoclonal abnormal mature B cells and more regulatory immune properties of T cell com...

    Authors: Jiusheng Deng, Andrea Pennati, Jonathon B. Cohen, Yuanqiang Wu, Spencer Ng, Jian Hui Wu, Christopher R. Flowers and Jacques Galipeau

    Citation: Journal of Translational Medicine 2016 14:106

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  29. Content type: Research

    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been established as an effective treatment for patients with hematological malignancies. Disease relapse remains a major cause of transplant f...

    Authors: X.-Y. Qin, Y. Wang, G.-X. Li, Y.-Z. Qin, F.-R. Wang, L.-P. Xu, H. Chen, W. Han, J.-Z. Wang, X.-H. Zhang, Y.-J. Chang, K.-Y. Liu, Z.-F. Jiang and X.-J. Huang

    Citation: Journal of Translational Medicine 2016 14:100

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  30. Content type: Research

    Natural Killer (NK) cell effector functions are dependent on phosphorylation of the mitogen-activated protein kinases (MAPK) pathway to produce an effective immune response for the clearance of target cells in...

    Authors: Teilah Kathryn Huth, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2016 14:97

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  31. Content type: Research

    Systemic lupus erythematosus (SLE) is an autoimmune-mediated chronic inflammatory disease. Half of patients with SLE suffer from lupus nephritis, which is major cause of death in SLE. TNF-like weak inducer of ...

    Authors: Hong-Ki Min, Sung-Min Kim, Jin-Sil Park, Jae-Kyeong Byun, Jennifer Lee, Seung-Ki Kwok, Young-Woo Park, Mi-La Cho and Sung-Hwan Park

    Citation: Journal of Translational Medicine 2016 14:98

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  32. Content type: Research

    An efficient strategy for programing dendritic cells (DCs) for cancer immunotherapy is the optimization of their maturation so that they can efficiently stimulate cancer-specific T cell responses. Interleukin ...

    Authors: Valérie Chabot, Laurence Martin, Daniel Meley, Luc Sensebé, Christophe Baron, Yvon Lebranchu, Frédéric Dehaut and Florence Velge-Roussel

    Citation: Journal of Translational Medicine 2016 14:93

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  33. Content type: Research

    Double-negative (DN) T cells could delay the onset and the progression of autoimmune diabetes, yet they were less efficient on reversing autoimmune diabetes. The aim of this study was to investigate whether th...

    Authors: Tianhui Liu, Min Cong, Guangyong Sun, Ping Wang, Yue Tian, Wen Shi, Xinmin Li, Hong You and Dong Zhang

    Citation: Journal of Translational Medicine 2016 14:57

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  34. Content type: Research

    Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA chall...

    Authors: Irma Mahmutovic Persson, Hamid Akbarshahi, Mandy Menzel, Angelica Brandelius and Lena Uller

    Citation: Journal of Translational Medicine 2016 14:52

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  35. Content type: Research

    Potent antitumor responses can be induced through cytokine immunotherapy. Interleukin (IL)-2 and granulocyte–macrophage colony-stimulating factor (GM-CSF) are among the most effective cytokines to induce tumo...

    Authors: Qian Wen, Wenjing Xiong, Jianchun He, Shimeng Zhang, Xialin Du, Sudong Liu, Juanjuan Wang, Mingqian Zhou and Li Ma

    Citation: Journal of Translational Medicine 2016 14:41

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  36. Content type: Research

    In vivo depletion of host T cells with antithymocyte globulin (ATG) is a common strategy for preventing graft-versus-host disease in allogeneic hematopoietic stem cell transplantation (HSCT). The total dose of...

    Authors: Jiangying Liu, Lan-Ping Xu, Zhilei Bian, Ying-Jun Chang, Yu Wang, Xiao-Hui Zhang and Xiao-Jun Huang

    Citation: Journal of Translational Medicine 2015 13:391

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  37. Content type: Research

    Impaired Toll-like receptor 2 (TLR2) function has been associated with the pathogenesis of atopic dermatitis (AD). However, there are only few studies reporting on the TLR2-induced immunological responses of ...

    Authors: Yangyang Yu, Yarui Zhang, Jie Zhang, Xia Dou, Hong Yang, Yong Shao, Kepeng Wang, Bo Yu, Wei Zhang and Hang Yung Alaster Lau

    Citation: Journal of Translational Medicine 2015 13:384

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  38. Content type: Research

    Autoimmune hemolytic anemia (AIHA), a life-threatening anemia with rapid onset, is caused by autoantibody directed to self red blood cells (RBCs). Currently, mechanisms underlying AIHA pathogenesis are largel...

    Authors: Xiangmao Bu, Tenglong Zhang, Chunhong Wang, Tao Ren and Zhenke Wen

    Citation: Journal of Translational Medicine 2015 13:381

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  39. Content type: Research

    Ipilimumab is an approved immunotherapy that has shown an overall survival benefit in patients with cutaneous metastatic melanoma in two phase III trials. As results of registrational trials might not answer a...

    Authors: Lisa Zimmer, Thomas K. Eigentler, Felix Kiecker, Jan Simon, Jochen Utikal, Peter Mohr, Carola Berking, Eckhart Kämpgen, Edgar Dippel, Rudolf Stadler, Axel Hauschild, Michael Fluck, Patrick Terheyden, Rainer Rompel, Carmen Loquai, Zeinab Assi…

    Citation: Journal of Translational Medicine 2015 13:351

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  40. Content type: Research

    Autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease are treated with TNF-alpha-blocking antibodies such as infliximab and adalimumab. A common side effect of therapeutic antibodies is...

    Authors: Arne Homann, Niels Röckendorf, Arno Kromminga, Andreas Frey and Uta Jappe

    Citation: Journal of Translational Medicine 2015 13:339

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  41. Content type: Research

    Trastuzumab is a humanized monoclonal antibody (mAb) currently used for the treatment of breast cancer (BC) patients with HER-2 overexpressing tumor subtype. Previous data reported the involvement of FcγRIIIA/...

    Authors: Silvia Boero, Anna Morabito, Barbara Banelli, Barbara Cardinali, Beatrice Dozin, Gianluigi Lunardi, Patrizia Piccioli, Sonia Lastraioli, Roberta Carosio, Sandra Salvi, Alessia Levaggi, Francesca Poggio, Alessia D’Alonzo, Massimo Romani, Lucia Del Mastro, Alessandro Poggi…

    Citation: Journal of Translational Medicine 2015 13:324

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    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:24

  42. Content type: Research

    Characterization of PD-L1 expression within clinically/radiologically negative but microscopically tumor positive sentinel lymph nodes (SLN) is important to our understanding of the relevance of this immune ch...

    Authors: Ahmad A. Tarhini, Haris Zahoor, Jennifer H. Yearley, Christopher Gibson, Zahra Rahman, Rachel Dubner, Uma N. M. Rao, Cindy Sander and John M. Kirkwood

    Citation: Journal of Translational Medicine 2015 13:319

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  43. Content type: Research

    Hepatitis B (HB) is an infectious disease with unfavorable consequence for patients and involved in chronic inflammation of liver. The present study aimed to investigate whether High-mobility group protein B (...

    Authors: JooYeon Jhun, SeungHoon Lee, HeeYeon Kim, Yang-Mi Her, Jae Kyeong Byun, Eun-Kyung Kim, Soon Kyu Lee, Mi-La Cho and Jong Young Choi

    Citation: Journal of Translational Medicine 2015 13:310

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  44. Content type: Research

    Several attempts to improve immune function in young children have been made and encouraging results have been collected with pidotimod (PDT), a synthetic dipeptide molecule that seems to have immunomodulatory...

    Authors: Susanna Esposito, Micaela Garziano, Veronica Rainone, Daria Trabattoni, Mara Biasin, Laura Senatore, Paola Marchisio, Marta Rossi, Nicola Principi and Mario Clerici

    Citation: Journal of Translational Medicine 2015 13:288

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  45. Content type: Research

    Bronchial smooth muscle cells (BSMCs) from severe asthmatics have been shown to overexpress the Th2-driving and asthma-associated cytokine IL-33. However, little is known regarding factors involved in BSMC pro...

    Authors: Jenny Calvén, Hamid Akbarshahi, Mandy Menzel, Cemil Korcan Ayata, Marco Idzko, Leif Bjermer and Lena Uller

    Citation: Journal of Translational Medicine 2015 13:281

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  46. Content type: Research

    Tapasin is a crucial component of the major histocompatibility (MHC) class I antigen presentation pathway. Defects in this pathway can lead to tumor immune evasion. The aim of this study was to test whether ta...

    Authors: Lena Sokol, Viktor H. Koelzer, Tilman T. Rau, Eva Karamitopoulou, Inti Zlobec and Alessandro Lugli

    Citation: Journal of Translational Medicine 2015 13:279

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  47. Content type: Research

    The transcription factor forkhead box P3 (Foxp3) is a master regulatory gene necessary for the development and function of CD4+CD25+ regulatory T cells (Tregs). Mesenchymal stem cells (MSC) have recently emerged ...

    Authors: Haizhi Qi, Guangshun Chen, Yaxun Huang, Zhongzhou Si and Jiequn Li

    Citation: Journal of Translational Medicine 2015 13:274

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  48. Content type: Review

    The complement mediators are the major effectors of the immune balance, which operates at the interface between the innate and adaptive immunity, and is vital for many immunoregulatory functions. Activation of...

    Authors: Mohammad Afzal Khan, Abdullah Mohammed Assiri and Dieter Clemens Broering

    Citation: Journal of Translational Medicine 2015 13:272

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