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Disease Biomarkers

Section edited by Xiangdong Wang and Hao Fang

The Disease Biomarkers section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Featured articles

Microfluidic devices for neutrophil chemotaxis studies

Review | Wenjie Zhao et al

Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model

Research | Han Wang et al

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Research | Michael A. Kiebish et al

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  1. The functions of the protein expressed in the nucleus and cytoplasm were different or opposite. The previous study found that oncogene Klf4 played a role of tumor suppressor in the nasopharyngeal cytoplasm. Cetux...

    Authors: Xiqing Li, Zunlan Zhao, Shijiang Yi, Lei Ma, Ming Li, Mingyue Liu, Yaping Zhang and Guangzhi Liu
    Citation: Journal of Translational Medicine 2018 16:183
  2. Patients with brain tumor or pancreatic cancer exhibit the poorest prognosis, while immune fitness and cellular immune exhaustion impacts their survival immensely. This work identifies differences in the immun...

    Authors: Zhenjiang Liu, Thomas Poiret, Qingda Meng, Martin Rao, Anna von Landenberg, Esther Schoutrop, Davide Valentini, Ernest Dodoo, Inti Peredo-Harvey and Markus Maeurer
    Citation: Journal of Translational Medicine 2018 16:182
  3. Circulating tumor cells (CTCs) have been suggested as potential prognostic indicators for multiple tumors, including gastric cancer; however, pre- and post-operative CTC changes in resectable gastric cancer an...

    Authors: Qiyue Zhang, Fei Shan, Ziyu Li, Jing Gao, Yilin Li, Lin Shen, Jiafu Ji and Ming Lu
    Citation: Journal of Translational Medicine 2018 16:171
  4. The carboxyl terminus of Hsc70-interacting protein (CHIP) is an E3 ubiquitin ligase that plays a controversial role in different cancers, either as a tumor suppressor or a tumor promoter. To date, the exact fu...

    Authors: Jingjing Xu, Jun Zhou, Hanjue Dai, Fei Liu, Wenjing Li, Wenjuan Wang and Feng Guo
    Citation: Journal of Translational Medicine 2018 16:169
  5. Symptomatic peripheral artery disease (PAD) is an atherosclerotic occlusive disease affecting the lower extremities. The cause of symptomatic PAD is atherosclerosis, vascular dysfunctions, impaired angiogenesi...

    Authors: Line Ea Hemstra, Anders Schlosser, Jes Sanddal Lindholt and Grith L. Sorensen
    Citation: Journal of Translational Medicine 2018 16:159
  6. Granulin epithelin precursor (GEP) is reported to function as a growth factor stimulating proliferation and migration, and conferring chemoresistance in many cancer types. However, the expression and functiona...

    Authors: Yi Pan, Siu Tim Cheung, Joanna Hung Man Tong, Ka Yee Tin, Wei Kang, Raymond Wai Ming Lung, Feng Wu, Hui Li, Simon Siu Man Ng, Tony Wing Chung Mak, Ka Fai To and Anthony Wing Hung Chan
    Citation: Journal of Translational Medicine 2018 16:150
  7. Diabetic kidney disease is a renal microvascular disease caused by diabetes, known as one of the most serious and lethal complications of diabetes. Early renal hypertrophy is the main pathological feature, whi...

    Authors: Yue Wang, Zong-ji Zheng, Yi-jie Jia, Yan-lin Yang and Yao-ming Xue
    Citation: Journal of Translational Medicine 2018 16:146
  8. Increasing studies showed that miR-200 family (miR-200s) clusters are aberrantly expressed in multiple human cancers, and miR-200s clusters function as tumor suppressor genes by affecting cell proliferation, self...

    Authors: Jing-dong Zhou, Liu-chao Zhang, Ting-juan Zhang, Yu Gu, De-hong Wu, Wei Zhang, Ji-chun Ma, Xiang-mei Wen, Hong Guo, Jiang Lin and Jun Qian
    Citation: Journal of Translational Medicine 2018 16:135
  9. Prostate cancer (PCa) is a fatal malignant tumor among males in the world and the metastasis is a leading cause for PCa death. Biomarkers are therefore urgently needed to detect PCa metastatic signature at the...

    Authors: Yuxin Lin, Feifei Chen, Li Shen, Xiaoyu Tang, Cui Du, Zhandong Sun, Huijie Ding, Jiajia Chen and Bairong Shen
    Citation: Journal of Translational Medicine 2018 16:134
  10. Cancer and coagulation activation are tightly related. The extent to which factors related to both these pathologic conditions concur to patient prognosis intensely animates the inherent research areas. The st...

    Authors: Chiara Mandoj, Laura Pizzuti, Domenico Sergi, Isabella Sperduti, Marco Mazzotta, Luigi Di Lauro, Antonella Amodio, Silvia Carpano, Anna Di Benedetto, Claudio Botti, Francesca Ferranti, Anna Antenucci, Maria Gabriella D’Alessandro, Paolo Marchetti, Silverio Tomao, Giuseppe Sanguineti…
    Citation: Journal of Translational Medicine 2018 16:129
  11. Recently, accumulating evidences have revealed that microRNA-106 (miR-106) may serve as a non-invasive and cost-effective biomarker in gastric cancer (GC) detection. However, inconsistent results have prevente...

    Authors: Qiliang Peng, Yi Shen, Kaisu Lin, Li Zou, Yuntian Shen and Yaqun Zhu
    Citation: Journal of Translational Medicine 2018 16:127
  12. Intra-tumoral heterogeneity has been recently addressed in different types of cancer, including breast cancer. A concept describing the origin of intra-tumoral heterogeneity is the cancer stem-cell hypothesis,...

    Authors: Pascale Kündig, Charlotte Giesen, Hartland Jackson, Bernd Bodenmiller, Bärbel Papassotirolopus, Sandra Nicole Freiberger, Catharine Aquino, Lennart Opitz and Zsuzsanna Varga
    Citation: Journal of Translational Medicine 2018 16:118

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:180

  13. A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in kidney tissue predicted a worse renal outcome. However, this finding must be validated in ind...

    Authors: Xiaoyan Zhang, Sufang Shi, Yan Ouyang, Meng Yang, Manman Shi, Xiaoxia Pan, Jicheng Lv, Zhaohui Wang, Hong Ren, Pingyan Shen, Weiming Wang, Hong Zhang, Jingyuan Xie and Nan Chen
    Citation: Journal of Translational Medicine 2018 16:115
  14. CA125 is a prevalently used serum biomarker for detecting ovarian cancer over the last three decades. However, it has a significant deficiency in screening for early-stage cancer. With the purpose of exploring...

    Authors: Zhuowei Gu, Yifeng He, Yue Zhang, Mo Chen, Keqi Song, Yuting Huang, Qing Li and Wen Di
    Citation: Journal of Translational Medicine 2018 16:114
  15. Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme obesity. Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors invol...

    Authors: Xin Chu, Qunyan Jin, Hui Chen, G. Craig Wood, Anthony Petrick, William Strodel, Jon Gabrielsen, Peter Benotti, Tooraj Mirshahi, David J. Carey, Christopher D. Still, Johanna K. DiStefano and Glenn S. Gerhard
    Citation: Journal of Translational Medicine 2018 16:108
  16. Human tissues are invaluable resources for researchers worldwide. Biobanks are repositories of such human tissues and can have a strategic importance for genetic research, clinical care, and future discoveries...

    Authors: Ehsan Ullah, Raghvendra Mall, Reda Rawi, Naima Moustaid-Moussa, Adeel A. Butt and Halima Bensmail
    Citation: Journal of Translational Medicine 2018 16:99

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:283

  17. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is clinically defined and characterised by persistent disabling tiredness and exertional malaise, leading to functional impairment.

    Authors: Alice M. Richardson, Don P. Lewis, Badia Kita, Helen Ludlow, Nigel P. Groome, Mark P. Hedger, David M. de Kretser and Brett A. Lidbury
    Citation: Journal of Translational Medicine 2018 16:97
  18. Urinary miRNAs may potentially serve as noninvasive biomarkers in various kidney diseases to reflect disease activity, severity and progression, especially those correlated with the pathogenesis of kidney dise...

    Authors: Changming Zhang, Shaoshan Liang, Shuiqin Cheng, Wei Li, Xia Wang, Chunxia Zheng, Caihong Zeng, Shaolin Shi, Lu Xie, Ke Zen and Zhihong Liu
    Citation: Journal of Translational Medicine 2018 16:91
  19. Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor prognosis. CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein. Recently, CD109 emerges as a potenti...

    Authors: Ruixia Qi, Fengyun Dong, Qiang Liu, Yoshiki Murakumo and Ju Liu
    Citation: Journal of Translational Medicine 2018 16:88
  20. Telocytes (TCs), a recently discovered novel type of interstitial cells, were also found in a wide variety of human and mammalian reproductive organs/tissues, including uterus, oviduct and placenta. Previously...

    Authors: Xiao-Juan Jiang, Dragos Cretoiu, Zong-Ji Shen and Xiao-Jun Yang
    Citation: Journal of Translational Medicine 2018 16:85
  21. S100A9 protein, which is recently classified as a novel damage associated molecular pattern, is released from stressed cells undergoing necrosis or secreted by living cells undergoing a stress that act as endo...

    Authors: Rui Wu, Yuhong Zhang, Yu Xiang, Yishu Tang, Fang Cui, Ju Cao, Lan Zhou, Yan You and Liang Duan
    Citation: Journal of Translational Medicine 2018 16:83
  22. Immune checkpoint inhibitors (anti-CTLA-4, anti-PD-1, or the combination) enhance anti-tumor immune responses, yielding durable clinical benefit in several cancer types, including melanoma. However, a subset o...

    Authors: Michael F. Gowen, Keith M. Giles, Danny Simpson, Jeremy Tchack, Hua Zhou, Una Moran, Zarmeena Dawood, Anna C. Pavlick, Shaohui Hu, Melissa A. Wilson, Hua Zhong, Michelle Krogsgaard, Tomas Kirchhoff and Iman Osman
    Citation: Journal of Translational Medicine 2018 16:82
  23. Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection. We analyzed the role of HI...

    Authors: Noemy Starita, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello
    Citation: Journal of Translational Medicine 2018 16:77
  24. This study addresses whether the association of adiponectin gene (ADIPOQ) variants with idiopathic recurrent pregnancy loss (RPL) is influenced by obesity.

    Authors: Maryam Dendana, Wael Bahia, Ramzi R. Finan, Mariam Al-Mutawa and Wassim Y. Almawi
    Citation: Journal of Translational Medicine 2018 16:76
  25. Controversy exists in previous studies on macrophage M1/M2 polarization in chronic obstructive pulmonary disease (COPD). We hypothesized that formyl peptide receptor (FPR), a marker of efferocytosis and mediat...

    Authors: Yung-Che Chen, Meng-Chih Lin, Chih-Hung Lee, Shih-Feng Liu, Chin-Chou Wang, Wen-Feng Fang, Tung-Ying Chao, Chao-Chien Wu, Yu-Feng Wei, Huang-Chih Chang, Chia-Cheng Tsen and Hung-Chen Chen
    Citation: Journal of Translational Medicine 2018 16:69
  26. MicroRNAs are of special interest in cancer research and hold significant promise as diagnostic and prognostic biomarkers for malignant disease. MiR-362-5p have been found to exert both oncogenic and tumor sup...

    Authors: Qiu-Ling Ma, Jing-Han Wang, Min Yang, Huan-ping Wang and Jie Jin
    Citation: Journal of Translational Medicine 2018 16:68
  27. Human neutrophil antigen 3 (HNA-3) is encoded by the SLC44A2 gene. Antibodies against HNAs can cause severe, often fatal, transfusion reactions, known as transfusion-related acute lung injury, and neonatal neu...

    Authors: Guo-Jin Ou, Pin-Can Su, Hao Yu, Xin Ji, Fan Liu, Sheng-Lan Wang, Yu-Jie Kong, Ling Li, Jue Wang, Zhong Liu and Willy Albert Flegel
    Citation: Journal of Translational Medicine 2018 16:67
  28. Circulating microRNAs (miRNAs) are emerging as novel biomarkers for detecting cardiovascular diseases. In this study, we aimed to investigate the usefulness of miRNAs as biomarkers in diagnosing and predicting...

    Authors: Yong Song, Hilda Higgins, Jing Guo, Katrina Harrison, En Nee Schultz, Belinda J. Hales, Eric K. Moses, Jack Goldblatt, Nicholas Pachter and Guicheng Zhang
    Citation: Journal of Translational Medicine 2018 16:42
  29. An extensive crosstalk co-regulates the Hippo and Wnt pathway. Preclinical studies revealed that the Hippo transducers YAP/TAZ mediate a number of oncogenic functions in gastric cancer (GC). Moreover, comprehe...

    Authors: Elisa Melucci, Beatrice Casini, Livia Ronchetti, Laura Pizzuti, Francesca Sperati, Matteo Pallocca, Francesca De Nicola, Frauke Goeman, Enzo Gallo, Carla Azzurra Amoreo, Domenico Sergi, Irene Terrenato, Patrizia Vici, Luigi Di Lauro, Maria Grazia Diodoro, Edoardo Pescarmona…
    Citation: Journal of Translational Medicine 2018 16:22
  30. Dental caries is a major worldwide oral disease afflicting a large proportion of children. As an important host factor of caries susceptibility, saliva plays a significant role in the occurrence and developmen...

    Authors: Kun Wang, Yufei Wang, Xiuqing Wang, Qian Ren, Sili Han, Longjiang Ding, Zhongcheng Li, Xuedong Zhou, Wei Li and Linglin Zhang
    Citation: Journal of Translational Medicine 2018 16:11
  31. Bladder cancer (BCa) is one of the most common cancers in the urinary system among the world. Previous studies suggested that TMEM40 expression level was significantly associated with clinicopathological param...

    Authors: Zhen-Fei Zhang, Han-Rong Zhang, Qing-Yan Zhang, Shu-Yu Lai, Yu-Zhen Feng, Yi Zhou, Si-Rong Zheng, Rong Shi and Jue-Yu Zhou
    Citation: Journal of Translational Medicine 2018 16:9
  32. To screen tumors with microsatellite instability (MSI) arising due to DNA mismatch repair deficiency (dMMR), a panel of five quasi-monomorphic mononucleotide-repeat markers amplified in a multiplex PCR (Pentap...

    Authors: Yuko Takehara, Takeshi Nagasaka, Akihiro Nyuya, Tomoko Haruma, Junko Haraga, Yoshiko Mori, Keiichiro Nakamura, Toshiyoshi Fujiwara, C. Richard Boland and Ajay Goel
    Citation: Journal of Translational Medicine 2018 16:5
  33. Plasma extracellular vesicles (EVs), especially exosome-like vesicles (ELVs), are being increasingly explored as a source of potential noninvasive disease biomarkers. The discovery of blood-based biomarkers as...

    Authors: Ruzena Stranska, Laurens Gysbrechts, Jens Wouters, Pieter Vermeersch, Katarzyna Bloch, Daan Dierickx, Graciela Andrei and Robert Snoeck
    Citation: Journal of Translational Medicine 2018 16:1
  34. In our previous study, we revealed that MEG3 was a tumor suppressor gene in retinoblastoma and inhibited proliferation of retinoblastoma cells by regulating the activity of the Wnt/β-catenin pathway. Here, we ...

    Authors: Yali Gao, Peng Huang and Jun Zhang
    Citation: Journal of Translational Medicine 2017 15:268
  35. Sepsis represents a complex disease with the dysregulated inflammatory response and high mortality rate. The goal of this study was to identify potential transcriptomic markers in developing pediatric sepsis b...

    Authors: Yiping Li, Yanhong Li, Zhenjiang Bai, Jian Pan, Jian Wang and Fang Fang
    Citation: Journal of Translational Medicine 2017 15:254
  36. Sprifermin (recombinant human fibroblast growth factor 18) is in clinical development as a potential disease-modifying osteoarthritis drug (DMOAD). In vitro studies have shown that cartilage regenerative prope...

    Authors: Ditte Reker, Cecilie F. Kjelgaard-Petersen, Anne Sofie Siebuhr, Martin Michaelis, Anne Gigout, Morten A. Karsdal, Christoph Ladel and Anne C. Bay-Jensen
    Citation: Journal of Translational Medicine 2017 15:250
  37. The role of single nucleotide polymorphisms (SNPs) associated with inflammatory bowel disease (IBD) is gaining interest. With the advent of novel therapies, personalized treatment in IBD is a future goal. We w...

    Authors: V. J. A. A. Nuij, M. P. Peppelenbosch, C. J. van der Woude and G. M. Fuhler
    Citation: Journal of Translational Medicine 2017 15:248
  38. Biomarkers of early plaque progression are still elusive. Myeloid DAP12-associating lectin-1 (MDL-1), also called CLEC5A, is a C-type lectin receptor implicated in the progression of multiple acute and chronic...

    Authors: Weixin Xiong, Haibo Wang, Lin Lu, Rui Xi, Fang Wang, Gang Gu and Rong Tao
    Citation: Journal of Translational Medicine 2017 15:234
  39. Developmental dysplasia of the hip (DDH) is a debilitating condition whose distinguishing signs include incomplete formation of the acetabulum leading to dislocation of the femur, accelerated wear of the artic...

    Authors: George Feldman, Arlene Offemaria, Hind Sawan, Javad Parvizi and Theresa A. Freeman
    Citation: Journal of Translational Medicine 2017 15:233
  40. Platelet autoantibody detection is critical for immune thrombocytopenia (ITP) diagnosis and prognosis. Therefore, we aimed to establish a quantitative flow cytometric immunobead assay (FCIA) for ITP platelet a...

    Authors: Juping Zhai, Mengyuan Ding, Tianjie Yang, Bin Zuo, Zhen Weng, Yunxiao Zhao, Jun He, Qingyu Wu, Changgeng Ruan and Yang He
    Citation: Journal of Translational Medicine 2017 15:214
  41. While the mortality rate is declining in the United States, the life expectancy gap among different population groups suggests a need to identify biomarkers to improve early identification of individuals at ri...

    Authors: Salman M. Tajuddin, Mike A. Nalls, Alan B. Zonderman and Michele K. Evans
    Citation: Journal of Translational Medicine 2017 15:208
  42. High expression of proviral integration site for Moloney murine leukemia virus-1 (PIM-1), a serine/threonine kinase, is associated with many cancers. The main purpose of this study were to investigate that the...

    Authors: Hui Cheng, Chongmei Huang, Xiaoqian Xu, Xiaoxia Hu, Shenglan Gong, Gusheng Tang, Xianmin Song, Weiping Zhang, Jianmin Wang, Li Chen and Jianmin Yang
    Citation: Journal of Translational Medicine 2017 15:179
  43. Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it ...

    Authors: Hui Wang, Christopher E. Barbieri, Jintang He, Yuqian Gao, Tujin Shi, Chaochao Wu, Athena A. Schepmoes, Thomas L. Fillmore, Sung-Suk Chae, Dennis Huang, Juan Miguel Mosquera, Wei-Jun Qian, Richard D. Smith, Sudhir Srivastava, Jacob Kagan, David G. Camp II…
    Citation: Journal of Translational Medicine 2017 15:175
  44. It is now recognized that asthma can present in different forms. Typically, asthma present with symptoms of wheeze, breathlessness and cough. Atypical forms of asthma such as cough variant asthma (CVA) or che...

    Authors: Chao Cao, Wen Li, Wen Hua, Fugui Yan, Hao Zhang, Huaqiong Huang, Yinghua Ying, Na Li, Fen Lan, Shaobin Wang, Xiao Chen, Jing Li, Jinkai Liu, Tianwen Lai, Zhengqiang Bao, Yuan Cao…
    Citation: Journal of Translational Medicine 2017 15:171
  45. Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to t...

    Authors: Whitney A. Sumner, William A. Stokes, Ayman Oweida, Kiersten L. Berggren, Jessica D. McDermott, David Raben, Diana Abbott, Bernard Jones, Gregory Gan and Sana D. Karam
    Citation: Journal of Translational Medicine 2017 15:168
  46. The purpose of this study was to explore gene copy number (GCN) variation of EGFR, HER2, c-MYC, and MET in patients with primary colorectal cancer (CRC).

    Authors: Yoonjin Kwak, Sumi Yun, Soo Kyung Nam, An Na Seo, Kyu Sang Lee, Eun Shin, Heung-Kwon Oh, Duck Woo Kim, Sung Bum Kang, Woo Ho Kim and Hye Seung Lee
    Citation: Journal of Translational Medicine 2017 15:167
  47. ETS2 is a downstream effector of the RAS/RAF/ERK pathway, which plays a critical role in the development of malignant tumor. However, the clinical impact of ETS2 expression in AML rema...

    Authors: Lin Fu, Huaping Fu, Qingyun Wu, Yifan Pang, Keman Xu, Lei Zhou, Jianlin Qiao, Xiaoyan Ke, Kailin Xu and Jinlong Shi
    Citation: Journal of Translational Medicine 2017 15:159
  48. Promoter methylation has emerged as a promising class of epigenetic biomarkers for diagnosis and prognosis of renal cell tumors (RCTs). Although differential gene promoter methylation patterns have been report...

    Authors: Ana Sílvia Pires-Luís, Pedro Costa-Pinheiro, Maria João Ferreira, Luís Antunes, Francisco Lobo, Jorge Oliveira, Rui Henrique and Carmen Jerónimo
    Citation: Journal of Translational Medicine 2017 15:149
  49. Influenza challenge trials are important for vaccine efficacy testing. Currently, disease severity is determined by self-reported scores to a list of symptoms which can be highly subjective. A more objective m...

    Authors: Julius Muller, Eneida Parizotto, Richard Antrobus, James Francis, Campbell Bunce, Amanda Stranks, Marshall Nichols, Micah McClain, Adrian V. S. Hill, Adaikalavan Ramasamy and Sarah C. Gilbert
    Citation: Journal of Translational Medicine 2017 15:134

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