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Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

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  1. Content type: Research

    Hemodialysis patients have higher rates of cardiovascular morbidity and mortality compared to the general population. Mannose-binding lectin (MBL) plays an important role in the development of cardiovascular d...

    Authors: Felix Poppelaars, Mariana Gaya da Costa, Stefan P. Berger, Solmaz Assa, Anita H. Meter-Arkema, Mohamed R. Daha, Willem J. van Son, Casper F. M. Franssen and Marc A. J. Seelen

    Citation: Journal of Translational Medicine 2016 14:236

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    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:245

  2. Content type: Research

    The dependency of miRNA abundance from physiological processes such as exercises remains partially understood. We set out to analyze the effect of physical exercises on miRNA profiles in blood and plasma of en...

    Authors: Anne Hecksteden, Petra Leidinger, Christina Backes, Stefanie Rheinheimer, Mark Pfeiffer, Alexander Ferrauti, Michael Kellmann, Farbod Sedaghat, Benjamin Meder, Eckart Meese, Tim Meyer and Andreas Keller

    Citation: Journal of Translational Medicine 2016 14:219

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    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:293

  3. Content type: Research

    Colorectal cancer is a preventable disease if caught at early stages. This disease is highly aggressive and has a higher incidence in African Americans. Several biomarkers and mutations of aggressive tumor beh...

    Authors: Hassan Ashktorab, Pia Hermann, Mehdi Nouraie, Babak Shokrani, Edward Lee, Tahmineh Haidary, Hassan Brim and Ulrike Stein

    Citation: Journal of Translational Medicine 2016 14:215

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  4. Content type: Research

    Individual patients show a large variability in albuminuria response to angiotensin receptor blockers (ARB). Identifying novel biomarkers that predict ARB response may help tailor therapy. We aimed to discover...

    Authors: Michelle J. Pena, Andreas Heinzel, Peter Rossing, Hans-Henrik Parving, Guido Dallmann, Kasper Rossing, Steen Andersen, Bernd Mayer and Hiddo J. L. Heerspink

    Citation: Journal of Translational Medicine 2016 14:203

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  5. Content type: Research

    Hepatocellular carcinoma (HCC), a primary liver malignancy, is the most common cancer in males and fourth common cancer in females in Taiwan. HCC patients usually have a poor prognosis due to late diagnosis. I...

    Authors: Yu-Chiau Shyu, Tung-Liang Lee, Mu-Jie Lu, Jim-Ray Chen, Rong-Nan Chien, Huang-Yang Chen, Ji-Fan Lin, Ann-Ping Tsou, Yu-Hsien Chen, Chia-Wen Hsieh and Ting-Shuo Huang

    Citation: Journal of Translational Medicine 2016 14:200

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  6. Content type: Research

    Occurrence and progression of hepatocellular carcinoma (HCC) are associated with hepatitis B virus (HBV) infection. miR-1269b is up-regulated in HCC cells and tissues. However, the regulation of miR-1269b expr...

    Authors: Xiao-xiao Kong, Yan-ru Lv, Li-ping Shao, Xiang-yang Nong, Guang-ling Zhang, Yi Zhang, Hong-xia Fan, Min Liu, Xin Li and Hua Tang

    Citation: Journal of Translational Medicine 2016 14:189

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  7. Content type: Research

    To date, there are no effective therapeutic targeting agents for triple-negative breast cancer (TNBC), and PD-L1 has presented potential as an effective marker of immunotherapeutic agents. The aim of this stud...

    Authors: Woo Young Sun, Yu Kyung Lee and Ja Seung Koo

    Citation: Journal of Translational Medicine 2016 14:173

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  8. Content type: Research

    MicroRNAs have the potential as diagnostic biomarkers and therapeutic targets in autoimmune diseases. However, very limited studies have evaluated the expression of microRNA profile in thyroid gland related to...

    Authors: Jin Zhu, Yuehua Zhang, Weichen Zhang, Wei Zhang, Linni Fan, Lu Wang, Yixiong Liu, Shasha Liu, Ying Guo, Yingmei Wang, Jun Yi, Qingguo Yan, Zhe Wang and Gaosheng Huang

    Citation: Journal of Translational Medicine 2016 14:166

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  9. Content type: Research

    Adjuvant chemotherapy in patients with resected esophageal squamous cell cancer (ESCC) remains controversial for its uncertain role in improving overall survival (OS). Nucleotide excision repair (NER) removes ...

    Authors: Fei Zhou, Meiling Zhu, Mengyun Wang, Lixin Qiu, Lei Cheng, Ming Jia, Jiaqing Xiang and Qingyi Wei

    Citation: Journal of Translational Medicine 2016 14:154

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  10. Content type: Research

    Diabetes testing using saliva, rather than blood and urine, could facilitate diabetes screening in public spaces. We previously identified 1,5-anhydro-d-glucitol (1,5-AG) in saliva as a diabetes biomarker. The Gl...

    Authors: Anna Halama, Michal Kulinski, Sara Abdul Kader, Noothan J. Satheesh, Abdul Badi Abou-Samra, Karsten Suhre and Ramzi M. Mohammad

    Citation: Journal of Translational Medicine 2016 14:140

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  11. Content type: Research

    The prognosis of children with metastatic stage 4 neuroblastoma (NB) has remained poor in the past decade.

    Authors: Daniela Formicola, Giuseppe Petrosino, Vito Alessandro Lasorsa, Piero Pignataro, Flora Cimmino, Simona Vetrella, Luca Longo, Gian Paolo Tonini, André Oberthuer, Achille Iolascon, Matthias Fischer and Mario Capasso

    Citation: Journal of Translational Medicine 2016 14:142

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  12. Content type: Research

    Esophageal squamous cell carcinoma (ESCC) is one of the most aggressively malignant tumors with dismal prognosis. Profilin 2 (PFN2) is an actin-binding protein that regulates the dynamics of actin polymerizati...

    Authors: Xiao-bin Cui, Shu-mao Zhang, Yue-xun Xu, Hong-wei Dang, Chun-xia Liu, Liang-hai Wang, Lan Yang, Jian-ming Hu, Wei-hua Liang, Jin-fang Jiang, Na Li, Yong Li, Yun-zhao Chen and Feng Li

    Citation: Journal of Translational Medicine 2016 14:137

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  13. Content type: Research

    There is an unmet need for more efficient patient stratification for receiving trastuzumab in the metastatic breast cancer (mBC) setting, since only part of such patients benefit from the addition of this agen...

    Authors: Helen Gogas, Vassiliki Kotoula, Zoi Alexopoulou, Christos Christodoulou, Ioannis Kostopoulos, Mattheos Bobos, Georgia Raptou, Elpida Charalambous, Eleftheria Tsolaki, Ioannis Xanthakis, George Pentheroudakis, Angelos Koutras, Dimitrios Bafaloukos, Pavlos Papakostas, Gerasimos Aravantinos, Amanda Psyrri…

    Citation: Journal of Translational Medicine 2016 14:136

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  14. Content type: Research

    The receptor for activated C kinase 1 (RACK1) is involved in various cancers, but its roles in nasopharyngeal carcinoma (NPC) have not yet been fully elucidated.

    Authors: Hong Peng, Ping-Gui Gong, Jin-Bang Li, Long-Mei Cai, Le Yang, Yun-yi Liu, Kai-tai Yao and Xin Li

    Citation: Journal of Translational Medicine 2016 14:131

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  15. Content type: Research

    Podocalyxin-like 1 (PODXL) is an anti-adhesive transmembrane protein that has been demonstrated to be an independent factor of poor prognosis in colorectal cancer (CRC). The gene encoding PODXL is located to c...

    Authors: Anna H. Larsson, Sophie Lehn, Sakarias Wangefjord, Emelie Karnevi, Eugenia Kuteeva, Magnus Sundström, Björn Nodin, Mathias Uhlén, Jakob Eberhard, Helgi Birgisson and Karin Jirström

    Citation: Journal of Translational Medicine 2016 14:128

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  16. Content type: Research

    The oncogenic role of the fibroblast growth factor receptor (FGFR) has been recognized in a number of different cancer types. However, the prognostic significance of FGFRs has not been elucidated yet in cervic...

    Authors: Chel Hun Choi, Joon-Yong Chung, Jae-Hoon Kim, Byoung-Gie Kim and Stephen M. Hewitt

    Citation: Journal of Translational Medicine 2016 14:124

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  17. Content type: Research

    Circulating microRNAs (miRNAs) emerge as novel biomarkers in cardiovascular diseases. Diagnosing acute pulmonary embolism (PE) remains challenging due to a diverse clinical presentation and the lack of specifi...

    Authors: Thorsten Kessler, Jeanette Erdmann, Baiba Vilne, Petra Bruse, Volkhard Kurowski, Patrick Diemert, Heribert Schunkert and Hendrik B. Sager

    Citation: Journal of Translational Medicine 2016 14:120

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  18. Content type: Review

    Annexins are Ca2+-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial rol...

    Authors: Mehdi Mirsaeidi, Sanaz Gidfar, Ann Vu and Dean Schraufnagel

    Citation: Journal of Translational Medicine 2016 14:89

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  19. Content type: Research

    S100A13 and high mobility group A (HMGA1) are known to play essential roles in the carcinogenesis and progression of cancer. However, the correlation between S100A13 and HMGA1 during cancer progression is not...

    Authors: Jing Zhong, Chang Liu, Ya-jun Chen, Qing-hai Zhang, Jing Yang, Xuan Kang, Si-Rui Chen, Ge-bo Wen, Xu-yu Zu and Ren-xian Cao

    Citation: Journal of Translational Medicine 2016 14:80

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  20. Content type: Research

    Low back pain and sciatica caused by intervertebral disc (IVD) disease are associated with inflammatory responses. The cytokine interleukin 17 (IL-17) is elevated in herniated and degenerated IVD tissues and a...

    Authors: Jing-kun Li, Lin Nie, Yun-peng Zhao, Yuan-qiang Zhang, Xiaoqing Wang, Shuai-shuai Wang, Yi Liu, Hua Zhao and Lei Cheng

    Citation: Journal of Translational Medicine 2016 14:77

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  21. Content type: Research

    Beta-2-microglobulin (B2M), a light chain subunit of the major histocompatibility complex (MHC) class I complex, has been implicated in tumorigenesis. However, whether it is expressed in different epithelial-t...

    Authors: Wenwen Sun, Lu Gui, Xulei Zuo, Lingyun Zhang, Daibing Zhou, Xiaoling Duan, Weimin Ren and Guoxiong Xu

    Citation: Journal of Translational Medicine 2016 14:75

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  22. Content type: Research

    Despite the efficacy of decitabine treatment in myelodysplastic syndrome (MDS), no definite predictor of response is known. In this study, we investigated whether the expression levels of human equilibrative n...

    Authors: Lingyun Wu, Wenhui Shi, Xiao Li, Chunkang Chang, Feng Xu, Qi He, Dong Wu, Jiying Su, Liyu Zhou, Luxi Song, Chao Xiao and Zheng Zhang

    Citation: Journal of Translational Medicine 2016 14:66

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  23. Content type: Research

    C14orf166 (chromosome 14 open reading frame 166) plays a crucial role in some tumors, but its role in bladder cancer hasn’t been explored.

    Authors: Mingkun Chen, Yunlin Ye, Baojia Zou, Suping Guo, Fangjian Zhou, Keshi Lu, Jianye Liu, Zhenzhou Xu, Hui Han, Zhuowei Liu, Yonghong Li, Kai Yao, Cundong Liu and Zike Qin

    Citation: Journal of Translational Medicine 2016 14:55

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  24. Content type: Research

    Urine based assays that can non-invasively detect bladder cancer (BCa) have the potential to reduce unnecessary and invasive procedures. The purpose of this study was to develop a multiplex immunoassay that ca...

    Authors: Yoshiko Shimizu, Hideki Furuya, Peter Bryant Greenwood, Owen Chan, Yunfeng Dai, Mark D. Thornquist, Steve Goodison and Charles J. Rosser

    Citation: Journal of Translational Medicine 2016 14:31

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  25. Content type: Research

    Mitochondrial dysfunction has been hypothesized to occur in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a disease characterized by fatigue, cognitive difficulties, pain, malaise, and exercise ...

    Authors: Paul Billing-Ross, Arnaud Germain, Kaixiong Ye, Alon Keinan, Zhenglong Gu and Maureen R. Hanson

    Citation: Journal of Translational Medicine 2016 14:19

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  26. Content type: Research

    The challenging diagnosis and poor prognosis of cholangiocarcinoma require the determination of biomarkers. Autoantibodies could be used in the clinic as diagnostic markers for the early detection of tumours. ...

    Authors: Mohammad Zahid Mustafa, Viet Hung Nguyen, François Le Naour, Eleonora De Martin, Elvire Beleoken, Catherine Guettier, Catherine Johanet, Didier Samuel, Jean-Charles Duclos-Vallee and Eric Ballot

    Citation: Journal of Translational Medicine 2016 14:17

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  27. Content type: Research

    Cabozantinib is an orally available inhibitor of tyrosine kinases including VEGFR2 and c-MET. We performed a post hoc analysis to find associations between select plasma biomarkers and treatment response in p...

    Authors: Raya Leibowitz-Amit, Melania Pintilie, Leila Khoja, Arun A. Azad, Raanan Berger, A. Douglas Laird, Dana T. Aftab, Kim N. Chi and Anthony M. Joshua

    Citation: Journal of Translational Medicine 2016 14:12

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  28. Content type: Research

    Recent studies have linked non-alcoholic fatty liver disease (NAFLD) to a reduced bone mineral density (BMD). We aimed to detect the quantitative association of liver fat content (LFC) and serum alanine aminot...

    Authors: Ming-Feng Xia, Huan-Dong Lin, Hong-Mei Yan, Hua Bian, Xin-Xia Chang, Lin-Shan Zhang, Wan-Yuan He and Xin Gao

    Citation: Journal of Translational Medicine 2016 14:11

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  29. Content type: Research

    Colorectal cancer (CRC) remains a major public concern. While conventional chemotherapeutic regimens have proved useful against advanced/metastatic diseases, progresses are to be made to effectively cure the l...

    Authors: Christophe Bounaix Morand du Puch, Michelle Nouaille, Stéphanie Giraud, Anaïs Labrunie, Sandrine Luce, Pierre-Marie Preux, François Labrousse, Alain Gainant, Nicole Tubiana-Mathieu, Valérie Le Brun-Ly, Denis Valleix, Angélique Guillaudeau, Laura Mesturoux, Béma Coulibaly, Christophe Lautrette and Muriel Mathonnet

    Citation: Journal of Translational Medicine 2016 14:10

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  30. Content type: Research

    Hepatocarcinogenesis is a multistep process characterized in patients with chronic liver diseases by a spectrum of hepatic nodules that mark the progression from regenerative nodules to dysplastic lesions foll...

    Authors: Chengyuan Peng, Slávka Kaščáková, Franck Chiappini, Natalia Olaya, Christophe Sandt, Ibraheem Yousef, Didier Samuel, Paul Dumas, Catherine Guettier and François Le Naour

    Citation: Journal of Translational Medicine 2016 14:9

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  31. Content type: Research

    Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been used to treat patients with melanoma. However, HDAC inh...

    Authors: Jiaqi Liu, Jianying Gu, Zihao Feng, Yanhong Yang, Ningwen Zhu, Weiyue Lu and Fazhi Qi

    Citation: Journal of Translational Medicine 2016 14:7

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  32. Content type: Research

    Orthotopic liver transplantation (OLT) can be an effective treatment option for certain patients with early stage hepatocellular carcinoma (HCC) meeting Milan, UCSF, or Hangzhou criteria. However, HCC recurren...

    Authors: Feng Xue, Brandon W. Higgs, Jiaqi Huang, Chris Morehouse, Wei Zhu, Xin Yao, Philip Brohawn, Zhan Xiao, Yinong Sebastian, Zheng Liu, Yun Xia, Dong Shen, Mike Kuziora, Zhengwei Dong, Hulin Han, Yi Gu…

    Citation: Journal of Translational Medicine 2015 13:379

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  33. Content type: Research

    Diabetic nephropathy (DN) is the leading cause of chronic kidney failure and end-stage kidney disease. More accurate and non-invasive test for the diagnosis and monitoring the progression of DN is urgently nee...

    Authors: Zhengguang Guo, Xuejiao Liu, Menglin Li, Chen Shao, Jianling Tao, Wei Sun and Mingxi Li

    Citation: Journal of Translational Medicine 2015 13:371

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  34. Content type: Research

    Plasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)—mainly associated with acute renal failure (ARF)—and incr...

    Authors: Fabien Herbert, Nicolas Tchitchek, Devendra Bansal, Julien Jacques, Sulabha Pathak, Christophe Bécavin, Constantin Fesel, Esther Dalko, Pierre-André Cazenave, Cristian Preda, Balachandran Ravindran, Shobhona Sharma, Bidyut Das and Sylviane Pied

    Citation: Journal of Translational Medicine 2015 13:369

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  35. Content type: Research

    Prompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in...

    Authors: Ruben Magni, Benjamin H. Espina, Ketul Shah, Benjamin Lepene, Christine Mayuga, Temple A. Douglas, Virginia Espina, Sally Rucker, Ross Dunlap, Emanuel F. III Petricoin, Mary Frekko Kilavos, Donald M. Poretz, Gilbert R. Irwin, Samuel M. Shor, Lance A. Liotta and Alessandra Luchini

    Citation: Journal of Translational Medicine 2015 13:346

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  36. Content type: Research

    Studies report conflicting evidence regarding the existence of a DCIS-associated premalignant pathway in BRCA mutation carriers. We aimed to examine the prevalence, phenotype, and expression of oncodrivers in ...

    Authors: Rachel L. Yang, Rosemarie Mick, Kathreen Lee, Holly L. Graves, Katherine L. Nathanson, Susan M. Domchek, Rachel R. Kelz, Paul J. Zhang and Brian J. Czerniecki

    Citation: Journal of Translational Medicine 2015 13:335

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  37. Content type: Research

    Several promising biomarkers have been found for RCC, but none of them has been used in clinical practice for predicting tumour progression. The most widely used features for predicting tumour aggressiveness s...

    Authors: Clizia Chinello, Marta Cazzaniga, Gabriele De Sio, Andrew James Smith, Angelica Grasso, Bernardo Rocco, Stefano Signorini, Marco Grasso, Silvano Bosari, Italo Zoppis, Giancarlo Mauri and Fulvio Magni

    Citation: Journal of Translational Medicine 2015 13:332

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  38. Content type: Research

    The wingless-type MMTV integration site (Wnt) signaling is a group of signal transduction pathways. In canonical Wnt pathway, Wnt ligands bind to low-density lipoprotein receptor-related protein 5 or 6 (LRP5 o...

    Authors: Jingsheng Tuo, Yujuan Wang, Rui Cheng, Yichao Li, Mei Chen, Fangfang Qiu, Haohua Qian, Defen Shen, Rosana Penalva, Heping Xu, Jian-Xing Ma and Chi-Chao Chan

    Citation: Journal of Translational Medicine 2015 13:330

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  39. Content type: Research

    Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer, and its underlying molecular mechanisms are poorly understood. Recent large-scale genome-wide association studies in Chinese Han populations...

    Authors: Xiao-Bin Cui, Yao-yuan Shen, Ting-ting Jin, Su Li, Ting-ting Li, Shu-mao Zhang, Hao Peng, Chun-xia Liu, Shu-gang Li, Lan Yang, Na Li, Jian-ming Hu, Jin-Fang Jiang, Man Li, Wei-hua Liang, Yong Li…

    Citation: Journal of Translational Medicine 2015 13:321

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  40. Content type: Research

    The gastric cancer is one of the most common and mortal cancer worldwide. The initial asymptomatic development and further nonspecific symptoms result in diagnosis at the advanced stage with poor prognosis. Ye...

    Authors: Agata Abramowicz, Anna Wojakowska, Agnieszka Gdowicz-Klosok, Joanna Polanska, Pawel Rodziewicz, Pawel Polanowski, Agnieszka Namysl-Kaletka, Monika Pietrowska, Jerzy Wydmanski and Piotr Widlak

    Citation: Journal of Translational Medicine 2015 13:304

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  41. Content type: Research

    Interferons (IFNs) have potent anti-proliferative, pro-apoptotic, and immunomodulatory activities against cancer. However, the clinical utility of IFNs is limited by toxicity and pharmacokinetics making it dif...

    Authors: Junjie Chen, Jialu Zhao, Lefu Chen, Nian Dong, Zhaojian Ying, Zhenzhen Cai, Dongxiang Ji, Yong Zhang, Li Dong, Yuping Li, Lei Jiang, Michael J. Holtzman and Chengshui Chen

    Citation: Journal of Translational Medicine 2015 13:293

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  42. Content type: Research

    Post-transcriptional regulation by heterogeneous ribonucleoproteins (hnRNPs) is an important regulatory paradigm in cancer development. Our proteomic analysis revealed hnRNPD overexpression in oral dysplasia ...

    Authors: Manish Kumar, Ajay Matta, Olena Masui, Gunjan Srivastava, Jatinder Kaur, Alok Thakar, Nootan Kumar Shukla, Ajoy RoyChoudhury, Meherchand Sharma, Paul G. Walfish, K. W. Michael Siu, Shyam Singh Chauhan and Ranju Ralhan

    Citation: Journal of Translational Medicine 2015 13:285

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  43. Content type: Research

    Activation of the MET oncogene promotes tumor growth, invasion and metastasis in several tumor types. Additionally, MET is activated as a compensatory pathway in the presence of EGFR blockade, thus resulting in a...

    Authors: Juan Madoz-Gúrpide, Sandra Zazo, Cristina Chamizo, Victoria Casado, Cristina Caramés, Eduardo Gavín, Ion Cristóbal, Jesús García-Foncillas and Federico Rojo

    Citation: Journal of Translational Medicine 2015 13:282

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  44. Content type: Review

    Definitive radiation therapy is the mainstay of treatment for early stage laryngeal squamous cell carcinoma (LSCC). However, up to 30% of the patients do not respond to radiotherapy. Unfortunately, we are unab...

    Authors: Danielle Maia, Ana Carolina de Carvalho, Maria Aderuza Horst, André Lopes Carvalho, Cristovam Scapulatempo-Neto and Andre Luiz Vettore

    Citation: Journal of Translational Medicine 2015 13:262

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  45. Content type: Research

    It has been well documented that alcohol and its metabolites induce injury and inflammation in the liver. However, there is no potential biomarker to monitor the extent of liver injury in alcoholic hepatitis p...

    Authors: Fatemeh Momen-Heravi, Banishree Saha, Karen Kodys, Donna Catalano, Abhishek Satishchandran and Gyongyi Szabo

    Citation: Journal of Translational Medicine 2015 13:261

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  46. Content type: Research

    Bevacizumab plus chemotherapy is a widely used therapeutic option for first-line treatment of metastatic colorectal cancer (mCRC). However, molecular predictors of bevacizumab efficacy have not yet been identi...

    Authors: Paola Ulivi, Emanuela Scarpi, Alessandro Passardi, Giorgia Marisi, Daniele Calistri, Wainer Zoli, Marzia Del Re, Giovanni Luca Frassineti, Davide Tassinari, Stefano Tamberi, Bernadette Vertogen and Dino Amadori

    Citation: Journal of Translational Medicine 2015 13:258

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  47. Content type: Research

    Long noncoding RNAs (lncRNAs) are emerging as key regulators governing fundamental biological processes, and their disorder expression involves in tumorigenesis. SPRY4-IT1 (SPRY4 intronic transcript 1), a lncRNA ...

    Authors: Min Xie, Feng-qi Nie, Ming Sun, Rui Xia, Yan-wen Liu, Peng Zhou, Wei De and Xiang-hua Liu

    Citation: Journal of Translational Medicine 2015 13:250

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  48. Content type: Research

    PARP inhibitors (PARPi) are a novel class of drugs with activity in patients with acquired or germline homologous recombination (HR) deficiency-associated high-grade serous ovarian cancer (HGSOC). We hypothesi...

    Authors: Jung-Min Lee, Nicolas Gordon, Jane B Trepel, Min-Jung Lee, Minshu Yu and Elise C Kohn

    Citation: Journal of Translational Medicine 2015 13:239

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  49. Content type: Research

    Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, and oocyte developmental competence is altered in patients with PCOS. In recent years microRNAs (miRNAs) have emerg...

    Authors: Suying Liu, Xuan Zhang, Changgen Shi, Jimin Lin, Guowu Chen, Bin Wu, Ligang Wu, Huijuan Shi, Yao Yuan, Weijin Zhou, Zhaogui Sun, Xi Dong and Jian Wang

    Citation: Journal of Translational Medicine 2015 13:238

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