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Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

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  1. Content type: Research

    Urine based assays that can non-invasively detect bladder cancer (BCa) have the potential to reduce unnecessary and invasive procedures. The purpose of this study was to develop a multiplex immunoassay that ca...

    Authors: Yoshiko Shimizu, Hideki Furuya, Peter Bryant Greenwood, Owen Chan, Yunfeng Dai, Mark D. Thornquist, Steve Goodison and Charles J. Rosser

    Citation: Journal of Translational Medicine 2016 14:31

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  2. Content type: Research

    Mitochondrial dysfunction has been hypothesized to occur in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a disease characterized by fatigue, cognitive difficulties, pain, malaise, and exercise ...

    Authors: Paul Billing-Ross, Arnaud Germain, Kaixiong Ye, Alon Keinan, Zhenglong Gu and Maureen R. Hanson

    Citation: Journal of Translational Medicine 2016 14:19

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  3. Content type: Research

    The challenging diagnosis and poor prognosis of cholangiocarcinoma require the determination of biomarkers. Autoantibodies could be used in the clinic as diagnostic markers for the early detection of tumours. ...

    Authors: Mohammad Zahid Mustafa, Viet Hung Nguyen, François Le Naour, Eleonora De Martin, Elvire Beleoken, Catherine Guettier, Catherine Johanet, Didier Samuel, Jean-Charles Duclos-Vallee and Eric Ballot

    Citation: Journal of Translational Medicine 2016 14:17

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  4. Content type: Research

    Recent studies have linked non-alcoholic fatty liver disease (NAFLD) to a reduced bone mineral density (BMD). We aimed to detect the quantitative association of liver fat content (LFC) and serum alanine aminot...

    Authors: Ming-Feng Xia, Huan-Dong Lin, Hong-Mei Yan, Hua Bian, Xin-Xia Chang, Lin-Shan Zhang, Wan-Yuan He and Xin Gao

    Citation: Journal of Translational Medicine 2016 14:11

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  5. Content type: Research

    Cabozantinib is an orally available inhibitor of tyrosine kinases including VEGFR2 and c-MET. We performed a post hoc analysis to find associations between select plasma biomarkers and treatment response in p...

    Authors: Raya Leibowitz-Amit, Melania Pintilie, Leila Khoja, Arun A. Azad, Raanan Berger, A. Douglas Laird, Dana T. Aftab, Kim N. Chi and Anthony M. Joshua

    Citation: Journal of Translational Medicine 2016 14:12

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  6. Content type: Research

    Hepatocarcinogenesis is a multistep process characterized in patients with chronic liver diseases by a spectrum of hepatic nodules that mark the progression from regenerative nodules to dysplastic lesions foll...

    Authors: Chengyuan Peng, Slávka Kaščáková, Franck Chiappini, Natalia Olaya, Christophe Sandt, Ibraheem Yousef, Didier Samuel, Paul Dumas, Catherine Guettier and François Le Naour

    Citation: Journal of Translational Medicine 2016 14:9

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  7. Content type: Research

    Colorectal cancer (CRC) remains a major public concern. While conventional chemotherapeutic regimens have proved useful against advanced/metastatic diseases, progresses are to be made to effectively cure the l...

    Authors: Christophe Bounaix Morand du Puch, Michelle Nouaille, Stéphanie Giraud, Anaïs Labrunie, Sandrine Luce, Pierre-Marie Preux, François Labrousse, Alain Gainant, Nicole Tubiana-Mathieu, Valérie Le Brun-Ly, Denis Valleix, Angélique Guillaudeau, Laura Mesturoux, Béma Coulibaly, Christophe Lautrette and Muriel Mathonnet

    Citation: Journal of Translational Medicine 2016 14:10

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  8. Content type: Research

    Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been used to treat patients with melanoma. However, HDAC inh...

    Authors: Jiaqi Liu, Jianying Gu, Zihao Feng, Yanhong Yang, Ningwen Zhu, Weiyue Lu and Fazhi Qi

    Citation: Journal of Translational Medicine 2016 14:7

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  9. Content type: Research

    Orthotopic liver transplantation (OLT) can be an effective treatment option for certain patients with early stage hepatocellular carcinoma (HCC) meeting Milan, UCSF, or Hangzhou criteria. However, HCC recurren...

    Authors: Feng Xue, Brandon W. Higgs, Jiaqi Huang, Chris Morehouse, Wei Zhu, Xin Yao, Philip Brohawn, Zhan Xiao, Yinong Sebastian, Zheng Liu, Yun Xia, Dong Shen, Mike Kuziora, Zhengwei Dong, Hulin Han, Yi Gu…

    Citation: Journal of Translational Medicine 2015 13:379

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  10. Content type: Research

    Diabetic nephropathy (DN) is the leading cause of chronic kidney failure and end-stage kidney disease. More accurate and non-invasive test for the diagnosis and monitoring the progression of DN is urgently nee...

    Authors: Zhengguang Guo, Xuejiao Liu, Menglin Li, Chen Shao, Jianling Tao, Wei Sun and Mingxi Li

    Citation: Journal of Translational Medicine 2015 13:371

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  11. Content type: Research

    Plasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)—mainly associated with acute renal failure (ARF)—and incr...

    Authors: Fabien Herbert, Nicolas Tchitchek, Devendra Bansal, Julien Jacques, Sulabha Pathak, Christophe Bécavin, Constantin Fesel, Esther Dalko, Pierre-André Cazenave, Cristian Preda, Balachandran Ravindran, Shobhona Sharma, Bidyut Das and Sylviane Pied

    Citation: Journal of Translational Medicine 2015 13:369

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  12. Content type: Research

    Prompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in...

    Authors: Ruben Magni, Benjamin H. Espina, Ketul Shah, Benjamin Lepene, Christine Mayuga, Temple A. Douglas, Virginia Espina, Sally Rucker, Ross Dunlap, Emanuel F. III Petricoin, Mary Frekko Kilavos, Donald M. Poretz, Gilbert R. Irwin, Samuel M. Shor, Lance A. Liotta and Alessandra Luchini

    Citation: Journal of Translational Medicine 2015 13:346

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  13. Content type: Research

    Studies report conflicting evidence regarding the existence of a DCIS-associated premalignant pathway in BRCA mutation carriers. We aimed to examine the prevalence, phenotype, and expression of oncodrivers in ...

    Authors: Rachel L. Yang, Rosemarie Mick, Kathreen Lee, Holly L. Graves, Katherine L. Nathanson, Susan M. Domchek, Rachel R. Kelz, Paul J. Zhang and Brian J. Czerniecki

    Citation: Journal of Translational Medicine 2015 13:335

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  14. Content type: Research

    Several promising biomarkers have been found for RCC, but none of them has been used in clinical practice for predicting tumour progression. The most widely used features for predicting tumour aggressiveness s...

    Authors: Clizia Chinello, Marta Cazzaniga, Gabriele De Sio, Andrew James Smith, Angelica Grasso, Bernardo Rocco, Stefano Signorini, Marco Grasso, Silvano Bosari, Italo Zoppis, Giancarlo Mauri and Fulvio Magni

    Citation: Journal of Translational Medicine 2015 13:332

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  15. Content type: Research

    The wingless-type MMTV integration site (Wnt) signaling is a group of signal transduction pathways. In canonical Wnt pathway, Wnt ligands bind to low-density lipoprotein receptor-related protein 5 or 6 (LRP5 o...

    Authors: Jingsheng Tuo, Yujuan Wang, Rui Cheng, Yichao Li, Mei Chen, Fangfang Qiu, Haohua Qian, Defen Shen, Rosana Penalva, Heping Xu, Jian-Xing Ma and Chi-Chao Chan

    Citation: Journal of Translational Medicine 2015 13:330

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  16. Content type: Research

    Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer, and its underlying molecular mechanisms are poorly understood. Recent large-scale genome-wide association studies in Chinese Han populations...

    Authors: Xiao-Bin Cui, Yao-yuan Shen, Ting-ting Jin, Su Li, Ting-ting Li, Shu-mao Zhang, Hao Peng, Chun-xia Liu, Shu-gang Li, Lan Yang, Na Li, Jian-ming Hu, Jin-Fang Jiang, Man Li, Wei-hua Liang, Yong Li…

    Citation: Journal of Translational Medicine 2015 13:321

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  17. Content type: Research

    The gastric cancer is one of the most common and mortal cancer worldwide. The initial asymptomatic development and further nonspecific symptoms result in diagnosis at the advanced stage with poor prognosis. Ye...

    Authors: Agata Abramowicz, Anna Wojakowska, Agnieszka Gdowicz-Klosok, Joanna Polanska, Pawel Rodziewicz, Pawel Polanowski, Agnieszka Namysl-Kaletka, Monika Pietrowska, Jerzy Wydmanski and Piotr Widlak

    Citation: Journal of Translational Medicine 2015 13:304

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  18. Content type: Research

    Interferons (IFNs) have potent anti-proliferative, pro-apoptotic, and immunomodulatory activities against cancer. However, the clinical utility of IFNs is limited by toxicity and pharmacokinetics making it dif...

    Authors: Junjie Chen, Jialu Zhao, Lefu Chen, Nian Dong, Zhaojian Ying, Zhenzhen Cai, Dongxiang Ji, Yong Zhang, Li Dong, Yuping Li, Lei Jiang, Michael J. Holtzman and Chengshui Chen

    Citation: Journal of Translational Medicine 2015 13:293

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  19. Content type: Research

    Post-transcriptional regulation by heterogeneous ribonucleoproteins (hnRNPs) is an important regulatory paradigm in cancer development. Our proteomic analysis revealed hnRNPD overexpression in oral dysplasia ...

    Authors: Manish Kumar, Ajay Matta, Olena Masui, Gunjan Srivastava, Jatinder Kaur, Alok Thakar, Nootan Kumar Shukla, Ajoy RoyChoudhury, Meherchand Sharma, Paul G. Walfish, K. W. Michael Siu, Shyam Singh Chauhan and Ranju Ralhan

    Citation: Journal of Translational Medicine 2015 13:285

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  20. Content type: Research

    Activation of the MET oncogene promotes tumor growth, invasion and metastasis in several tumor types. Additionally, MET is activated as a compensatory pathway in the presence of EGFR blockade, thus resulting in a...

    Authors: Juan Madoz-Gúrpide, Sandra Zazo, Cristina Chamizo, Victoria Casado, Cristina Caramés, Eduardo Gavín, Ion Cristóbal, Jesús García-Foncillas and Federico Rojo

    Citation: Journal of Translational Medicine 2015 13:282

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  21. Content type: Research

    It has been well documented that alcohol and its metabolites induce injury and inflammation in the liver. However, there is no potential biomarker to monitor the extent of liver injury in alcoholic hepatitis p...

    Authors: Fatemeh Momen-Heravi, Banishree Saha, Karen Kodys, Donna Catalano, Abhishek Satishchandran and Gyongyi Szabo

    Citation: Journal of Translational Medicine 2015 13:261

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  22. Content type: Review

    Definitive radiation therapy is the mainstay of treatment for early stage laryngeal squamous cell carcinoma (LSCC). However, up to 30% of the patients do not respond to radiotherapy. Unfortunately, we are unab...

    Authors: Danielle Maia, Ana Carolina de Carvalho, Maria Aderuza Horst, André Lopes Carvalho, Cristovam Scapulatempo-Neto and Andre Luiz Vettore

    Citation: Journal of Translational Medicine 2015 13:262

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  23. Content type: Research

    Bevacizumab plus chemotherapy is a widely used therapeutic option for first-line treatment of metastatic colorectal cancer (mCRC). However, molecular predictors of bevacizumab efficacy have not yet been identi...

    Authors: Paola Ulivi, Emanuela Scarpi, Alessandro Passardi, Giorgia Marisi, Daniele Calistri, Wainer Zoli, Marzia Del Re, Giovanni Luca Frassineti, Davide Tassinari, Stefano Tamberi, Bernadette Vertogen and Dino Amadori

    Citation: Journal of Translational Medicine 2015 13:258

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  24. Content type: Research

    Long noncoding RNAs (lncRNAs) are emerging as key regulators governing fundamental biological processes, and their disorder expression involves in tumorigenesis. SPRY4-IT1 (SPRY4 intronic transcript 1), a lncRNA ...

    Authors: Min Xie, Feng-qi Nie, Ming Sun, Rui Xia, Yan-wen Liu, Peng Zhou, Wei De and Xiang-hua Liu

    Citation: Journal of Translational Medicine 2015 13:250

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  25. Content type: Research

    Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, and oocyte developmental competence is altered in patients with PCOS. In recent years microRNAs (miRNAs) have emerg...

    Authors: Suying Liu, Xuan Zhang, Changgen Shi, Jimin Lin, Guowu Chen, Bin Wu, Ligang Wu, Huijuan Shi, Yao Yuan, Weijin Zhou, Zhaogui Sun, Xi Dong and Jian Wang

    Citation: Journal of Translational Medicine 2015 13:238

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  26. Content type: Research

    PARP inhibitors (PARPi) are a novel class of drugs with activity in patients with acquired or germline homologous recombination (HR) deficiency-associated high-grade serous ovarian cancer (HGSOC). We hypothesi...

    Authors: Jung-Min Lee, Nicolas Gordon, Jane B Trepel, Min-Jung Lee, Minshu Yu and Elise C Kohn

    Citation: Journal of Translational Medicine 2015 13:239

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  27. Content type: Research

    Accumulated evidence suggests that dysregulated expression of long non-coding RNAs (lncRNAs) may play a critical role in tumorigenesis and prognosis of cancer, indicating the potential utility of lncRNAs as ca...

    Authors: Meng Zhou, Maoni Guo, Dongfeng He, Xiaojun Wang, Yinqiu Cui, Haixiu Yang, Dapeng Hao and Jie Sun

    Citation: Journal of Translational Medicine 2015 13:231

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  28. Content type: Research

    SERPINA1 is the gene for alpha-1 antitrypsin (AAT), an acute phase protein with anti-protease and immunoregulatory activities. Mutations in SERPINA1 gene cause AAT deficiency and predispose individuals to earl...

    Authors: Nerea Matamala, Maria Teresa Martínez, Beatriz Lara, Laura Pérez, Irene Vázquez, Azucena Jimenez, Miguel Barquín, Ilaria Ferrarotti, Ignacio Blanco, Sabina Janciauskiene and Beatriz Martinez-Delgado

    Citation: Journal of Translational Medicine 2015 13:211

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  29. Content type: Research

    Clinical therapy for metastatic colorectal cancer (CRC) remains limited, especially when the tumor harbors a KRAS mutation. This study aimed to identify prognostic biomarkers in CRC that are accessible for the...

    Authors: Anne-France le Rolle, Thang K Chiu, Michael Fara, Jinru Shia, Zhaoshi Zeng, Martin R Weiser, Philip B Paty and Vi K Chiu

    Citation: Journal of Translational Medicine 2015 13:199

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  30. Content type: Review

    There is an emerging demand for the use of molecular profiling to facilitate biomarker identification and development, and to stratify patients for more efficient treatment decisions with reduced adverse effec...

    Authors: Jin-Qiu Chen, Lalage M Wakefield and David J Goldstein

    Citation: Journal of Translational Medicine 2015 13:182

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  31. Content type: Research

    The purpose of this study was to examine the expression of metabolism-related proteins according to metastatic site in metastatic breast cancer and to assess the implication of site-specific differential expre...

    Authors: Hye Min Kim, Woo Hee Jung and Ja Seung Koo

    Citation: Journal of Translational Medicine 2014 12:354

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  32. Content type: Research

    In end-stage heart failure (HF), the implantation of a left ventricular assist device (LVAD) is able to induce reverse remodeling. Cellular proteases, such as cathepsins, are involved in the progression of HF....

    Authors: Andrea D’Amico, Rosetta Ragusa, Raffaele Caruso, Tommaso Prescimone, Sandra Nonini, Manuela Cabiati, Silvia Del Ry, Maria Giovanna Trivella, Daniela Giannessi and Chiara Caselli

    Citation: Journal of Translational Medicine 2014 12:350

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  33. Content type: Research

    Many current therapies for metastatic castration-resistant prostate cancer (mCRPC) are aimed at AR signaling; however, resistance to these therapies is inevitable. To personalize CRPC therapy in an individual ...

    Authors: Edwin E Reyes, David J VanderWeele, Masis Isikbay, Ryan Duggan, Alexa Campanile, Walter M Stadler, Donald J Vander Griend and Russell Z Szmulewitz

    Citation: Journal of Translational Medicine 2014 12:313

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  34. Content type: Research

    Human replication factor C4 (RFC4) is involved in DNA replication as a clamp loader and is aberrantly regulated across a range of cancers. The current study aimed to investigate the function of RFC4 in colorec...

    Authors: Jun Xiang, Lekun Fang, Yanxin Luo, Zuli Yang, Yi Liao, Ji Cui, Meijin Huang, Zihuan Yang, Yan Huang, Xinjuan Fan, Huashe Wang, Lei Wang, Junsheng Peng and Jianping Wang

    Citation: Journal of Translational Medicine 2014 12:320

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  35. Content type: Research

    The role of miRNAs in familial breast cancer (fBC) is poorly investigated as also in the BRCA-like tumors. To identify a specific miRNA expression pattern which could allow a better fBC classification not only...

    Authors: Katia Danza, Simona De Summa, Brunella Pilato, Massimo Carella, Orazio Palumbo, Ondina Popescu, Angelo Paradiso, Rosamaria Pinto and Stefania Tommasi

    Citation: Journal of Translational Medicine 2014 12:319

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  36. Content type: Research

    Among genitourinary malignancies, bladder cancer (BCa) ranks second in both prevalence and cause of death. Biomarkers of BCa for diagnosis, prognosis and disease surveillance could potentially help prevent pro...

    Authors: Brian K McNeil, Maximiliano Sorbellini, Robert L Grubb III, Andrea B Apolo, Fabiola Cecchi, Gagani Athauda, Benjamin Cohen, Alessio Giubellino, Haley Simpson, Piyush K Agarwal, Jonathan Coleman, Robert H Getzenberg, George J Netto, Joanna Shih, W Marston Linehan, Peter A Pinto…

    Citation: Journal of Translational Medicine 2014 12:199

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  37. Content type: Research

    Pancreatic cancer and other pancreaticobiliary type periampullary adenocarcinomas have a dismal prognosis even after resection and neoadjuvant chemotherapy. Intestinal type periampullary adenocarcinomas genera...

    Authors: Jacob Elebro, Margareta Heby, Alexander Gaber, Björn Nodin, Liv Jonsson, Richard Fristedt, Mathias Uhlén, Karin Jirström and Jakob Eberhard

    Citation: Journal of Translational Medicine 2014 12:289

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  38. Content type: Research

    Glioblastoma (GBM) is the most common and lethal intracranial malignancy in adults, with dismal prognosis despite multimodal therapies. Tectonic family member 1 (TCTN1) is a protein involved in a diverse range...

    Authors: Delong Meng, Yuanyuan Chen, Yingjie Zhao, Jingkun Wang, Dapeng Yun, Song Yang, Juxiang Chen, Hongyan Chen and Daru Lu

    Citation: Journal of Translational Medicine 2014 12:288

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  39. Content type: Research

    The major cancer related mortality is caused by metastasis and invasion. It is important to identify genes regulating metastasis and invasion in order to curtail metastatic spread of cancer cells.

    Authors: Chih-Hao Chang, Tan-Chi Fan, Jyh-Cherng Yu, Guo-Shiou Liao, You-Chin Lin, Arthur Chun-Chieh Shih, Wen-Hsiung Li and Alice Lin-Tsing Yu

    Citation: Journal of Translational Medicine 2014 12:257

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  40. Content type: Research

    Human cystatin C (HCC) is a potential biomarker for tubular damage and impaired renal function. It is difficult to obtain efficient paired monoclonal antibodies against HCC with low molecular to meet the requi...

    Authors: Renren Jiang, Chao Xu, Xiaoli Zhou, Tianhao Wang and Gang Yao

    Citation: Journal of Translational Medicine 2014 12:205

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  41. Content type: Research

    Platinum-based chemotherapy improves survival among patients with non-small cell lung cancer (NSCLC), but the efficiency is limited due to resistance. In this study, we aimed to identify the expression of Auro...

    Authors: Jie Xu, Cai-feng Yue, Wei-hua Zhou, Yuan-min Qian, Yan Zhang, Shao-wu Wang, An-wen Liu and Quentin Liu

    Citation: Journal of Translational Medicine 2014 12:200

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  42. Content type: Research

    Toll-like receptor 4 (TLR4), a lipopolysaccharide (LPS) receptor complex signal-transducing molecule, plays a crucial role in sensing LPS from gram-negative bacteria. TLR4 signaling pathway activation by LPS p...

    Authors: Ashham Mansur, Luisa von Gruben, Aron F Popov, Maximilian Steinau, Ingo Bergmann, Daniel Ross, Michael Ghadimi, Tim Beissbarth, Martin Bauer and José Hinz

    Citation: Journal of Translational Medicine 2014 12:177

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  43. Content type: Methodology

    Overall cure rates in acute myeloid leukemia (AML) continue to range between 60-65% with disease relapse being a major cause of mortality. The PI3K-Akt-mTOR kinase pathway plays a vital role in pro-survival si...

    Authors: Himalee Sabnis, Heath L Bradley, Silvia T Bunting, Todd M Cooper and Kevin D Bunting

    Citation: Journal of Translational Medicine 2014 12:166

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  44. Content type: Research

    HER2 status assessment is a prerequisite for the establishment of an appropriate treatment strategy in gastric cancer. Gastric cancers are very heterogeneous and separate evaluations of gene amplification and ...

    Authors: Dominique Werner, Achim Battmann, Kristina Steinmetz, Tobin Jones, Tiffany Lamb, Michele Martinez, Hans-Michael Altmannsberger and Salah-Eddin Al-Batran

    Citation: Journal of Translational Medicine 2014 12:160

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  45. Content type: Research

    Lung adenocarcinoma is a heterogernous disease that creates challenges for classification and management. The purpose of this study is to identify specific miRNA markers closely associated with the survival of...

    Authors: Xuelian Li, Yunrui Shi, Zhihua Yin, Xiaoxia Xue and Baosen Zhou

    Citation: Journal of Translational Medicine 2014 12:159

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  46. Content type: Research

    Telomere dysfunction is important in carcinogenesis, and recently, stathmin and elongation factor 1α (EF1α) were reported to be up-regulated in telomere dysfunctional mice.

    Authors: Ei Yong Ahn, Jeong Eun Yoo, Hyungjin Rhee, Myung Soo Kim, Junjeong Choi, Jung Eun Ko, Jee San Lee and Young Nyun Park

    Citation: Journal of Translational Medicine 2014 12:154

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