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Disease Biomarkers

Section edited by Xiangdong Wang and Hao Fang

The Disease Biomarkers section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Featured articles

Microfluidic devices for neutrophil chemotaxis studies

Review | Wenjie Zhao et al

Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model

Research | Han Wang et al

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Research | Michael A. Kiebish et al

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  1. Human saliva is a protein-rich, easily accessible source of potential biomarkers for the diagnosis of oral and systemic diseases. However, little is known about the changes in salivary proteome associated with...

    Authors: Kun Wang, Xiuqing Wang, Sainan Zheng, Yumei Niu, Wenyue Zheng, Xi Qin, Zhongcheng Li, Junyuan Luo, Wentao Jiang, Xuedong Zhou, Wei Li and Linglin Zhang
    Citation: Journal of Translational Medicine 2018 16:293
  2. Chronic kidney disease (CKD) is recognised as a global public health problem, more prevalent in older persons and associated with multiple co-morbidities. Diabetes mellitus and hypertension are common aetiolog...

    Authors: M. Cañadas-Garre, K. Anderson, J. McGoldrick, A. P. Maxwell and A. J. McKnight
    Citation: Journal of Translational Medicine 2018 16:292
  3. Epidemiological evidence suggests sex difference in serum uric acid (SUA) and alanine aminotransferase (ALT) might be a potential explanation for the gender difference in prevalence of non-alcoholic fatty live...

    Authors: Huanhuan Yang, Deming Li, Xiaochao Song, Fang Liu, Xinjing Wang, Qinghua Ma, Xi Zhang and Xinli Li
    Citation: Journal of Translational Medicine 2018 16:285
  4. Molecular and cellular pathophysiological events occurring in the majority of rare kidney diseases remain to be elucidated. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare au...

    Authors: M. Vall-Palomar, J. Arévalo, G. Ariceta and A. Meseguer
    Citation: Journal of Translational Medicine 2018 16:278
  5. Systemic inflammation and immune dysfunction has been proved to be significantly associated with cancer progression and metastasis in many cancer types, including colorectal cancer. We examined the prognostic ...

    Authors: Qian-Kun Xie, Ping Chen, Wan-Ming Hu, Peng Sun, Wen-Zhuo He, Chang Jiang, Peng-Fei Kong, Shou-Sheng Liu, Hai-Tian Chen, Yuan-Zhong Yang, Dan Wang, Lin Yang and Liang-Ping Xia
    Citation: Journal of Translational Medicine 2018 16:273
  6. In the recent years Plasmodium vivax has been reported to cause severe infections associated with mortality. Clinical evaluation has limited accuracy for the early identification of the patients progressing towar...

    Authors: Hargobinder Kaur, Rakesh Sehgal, Archit Kumar, Alka Sehgal, Devendra Bansal and Ali A. Sultan
    Citation: Journal of Translational Medicine 2018 16:272
  7. Limited evidence suggests that inherited predisposing risk variants might affect the disease outcome. In this study, we analyzed the effect of genome-wide association studies—identified breast cancer-risk sing...

    Authors: Fangmeng Fu, Wenhui Guo, Yuxiang Lin, Bangwei Zeng, Wei Qiu, Meng Huang and Chuan Wang
    Citation: Journal of Translational Medicine 2018 16:270
  8. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and controversial clinical condition without having established causative factors. Increasing numbers of cases during past decade have c...

    Authors: Santa Rasa, Zaiga Nora-Krukle, Nina Henning, Eva Eliassen, Evelina Shikova, Thomas Harrer, Carmen Scheibenbogen, Modra Murovska and Bhupesh K. Prusty
    Citation: Journal of Translational Medicine 2018 16:268
  9. Substantial evidence indicates that β-catenin is a pivotal regulator that contributes to the initiation and development of various types of diseases. Recently, β-catenin can be detected in human serum and also...

    Authors: Liang Duan, Qianfan Yang, Jun Yang, Qin Hu, Bo Wang, Pu Li and Weixian Chen
    Citation: Journal of Translational Medicine 2018 16:265
  10. Increasing evidence has underscored the role of long non-coding RNAs (lncRNAs) acting as competing endogenous RNAs (ceRNAs) in the development and progression of tumors. Nevertheless, lncRNA biomarkers in lncR...

    Authors: Chun-Ni Fan, Lei Ma and Ning Liu
    Citation: Journal of Translational Medicine 2018 16:264
  11. The airway smooth muscle (ASM) plays an indispensable role in airway structure and function. Dysfunction in ASM plays a central role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and cont...

    Authors: Furong Yan, Hongzhi Gao, Hong Zhao, Madhav Bhatia and Yiming Zeng
    Citation: Journal of Translational Medicine 2018 16:262
  12. MUC4 is a membrane-bound mucin that promotes carcinogenetic progression and is often proposed as a promising biomarker for various carcinomas. In this manuscript, we analyzed large scale genomic datasets in or...

    Authors: Nicolas Jonckheere and Isabelle Van Seuningen
    Citation: Journal of Translational Medicine 2018 16:259
  13. Even though multi-focused psychosocial residence rehabilitation intervention (MPRRI) programs are widely implemented by the Shanghai Cancer Rehabilitation Club, these programs have not been rigorously evaluate...

    Authors: Xuefen Chen, Xiaohuan Gong, Changhong Shi, Li Sun, Zheng Tang, Zhengping Yuan, Jiwei Wang and Jinming Yu
    Citation: Journal of Translational Medicine 2018 16:250
  14. Metabolomics represent a valuable tool to recover biological information using body fluids and may help to characterize pathophysiological mechanisms of the studied disease. This approach has not been widely u...

    Authors: Abdellah Tebani, Lenaig Abily-Donval, Isabelle Schmitz-Afonso, Bénédicte Héron, Monique Piraud, Jérôme Ausseil, Farid Zerimech, Bruno Gonzalez, Stéphane Marret, Carlos Afonso and Soumeya Bekri
    Citation: Journal of Translational Medicine 2018 16:248
  15. We have previously reported that nuclear expression of the Hippo transducer TAZ in association with Wnt pathway mutations negatively impacts survival outcomes in advanced gastric cancer (GC) patients. Here, we...

    Authors: Matteo Pallocca, Frauke Goeman, Francesca De Nicola, Elisa Melucci, Francesca Sperati, Irene Terrenato, Laura Pizzuti, Beatrice Casini, Enzo Gallo, Carla Azzurra Amoreo, Patrizia Vici, Luigi Di Lauro, Simonetta Buglioni, Maria Grazia Diodoro, Edoardo Pescarmona, Marco Mazzotta…
    Citation: Journal of Translational Medicine 2018 16:247
  16. Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionalit...

    Authors: Di Liu, Xi Chu, Hao Wang, Jing Dong, Si-Qi Ge, Zhong-Yao Zhao, Hong-Li Peng, Ming Sun, Li-Juan Wu, Man-Shu Song, Xiu-Hua Guo, Qun Meng, You-Xin Wang, Gordan Lauc and Wei Wang
    Citation: Journal of Translational Medicine 2018 16:235
  17. Expression of the NPM1 gene, encoding nucleophosmin, is upregulated in cancers. Although more than ten NPM1 transcripts are known, the reports were usually limited to one predominant transcript. In leukemia, the

    Authors: Luiza Handschuh, Pawel Wojciechowski, Maciej Kazmierczak, Malgorzata Marcinkowska-Swojak, Magdalena Luczak, Krzysztof Lewandowski, Mieczyslaw Komarnicki, Jacek Blazewicz, Marek Figlerowicz and Piotr Kozlowski
    Citation: Journal of Translational Medicine 2018 16:232
  18. There is increasing interest in using extracellular vesicle-derived microRNAs (miRNAs) as biomarkers in renal dysfunction and injury. Preliminary evidence indicates that miRNAs regulate the progression of glom...

    Authors: Javier Perez-Hernandez, Dolores Olivares, Maria J. Forner, Ana Ortega, Elena Solaz, Fernando Martinez, Felipe J. Chaves, Josep Redon and Raquel Cortes
    Citation: Journal of Translational Medicine 2018 16:228
  19. Circulating exosomes from prostate cancer (PCa) patients undergoing radiotherapy are attractive candidate biomarkers for monitoring treatment response. Multiple workflows for isolation and content characteriza...

    Authors: Bijaya Malla, Daniel M. Aebersold and Alan Dal Pra
    Citation: Journal of Translational Medicine 2018 16:223
  20. MicroRNAs play roles in the pathogenesis of bronchial asthma. However, the mechanism of miR-29c in allergic asthma remains unclear. This study is to elucidate the regulation of Th cell differentiation by miR-2...

    Authors: Xinxing Zhang, Xin Zhao, Huiming Sun, Yongdong Yan, Li Huang, Wenjin Gu, Wujun Jiang, Yuqing Wang, Canhong Zhu, Wei Ji, Chuangli Hao and Zhengrong Chen
    Citation: Journal of Translational Medicine 2018 16:218
  21. Little has been known about the role of non-coding RNA regulatory network in the patterns of growth and invasiveness of gastric cancer (GC) development.

    Authors: Jia Cheng, Huiqin Zhuo, Mao Xu, Linpei Wang, Hao Xu, Jigui Peng, Jingjing Hou, Lingyun Lin and Jianchun Cai
    Citation: Journal of Translational Medicine 2018 16:216
  22. Membranous glomerulonephritis (MGN) is the most common cause of nephrotic syndrome in adult patients. Despite extensive evidences suggested that many immune-related genes could serve as effective biomarkers in...

    Authors: Chengwei Zhang, Lei Leng, Xiaoming Zhang, Yao Zhao and Zhaozheng Li
    Citation: Journal of Translational Medicine 2018 16:210
  23. The early and accurate diagnosis of tuberculosis (TB) is critical for controlling the global TB epidemic. Although early studies have supported the potential role of cytokine biomarkers in blood for the diagno...

    Authors: Sen Wang, Yang Li, Yaojie Shen, Jing Wu, Yan Gao, Shu Zhang, Lingyun Shao, Jialin Jin, Ying Zhang and Wenhong Zhang
    Citation: Journal of Translational Medicine 2018 16:206
  24. Abnormal microRNAs (miRNAs) were reported to be involved in the mechanism of Graves’ disease (GD). Dysregulated miRNAs may be overlapping in different cells and can be secreted to circulation. We chose miRNAs ...

    Authors: Xinxin Chen, Fengjiao Huang, Yicheng Qi, Mengxi Zhou, Qinglei Yin, Ying Peng, Yulin Zhou, Guang Ning and Shu Wang
    Citation: Journal of Translational Medicine 2018 16:188
  25. Implantation failure is not only a major cause of early pregnancy loss, but it is also an obstacle to assisted reproductive technologies. The identification of potential circulating biomarkers for recurrent mi...

    Authors: Qian Yang, Wen-Wen Gu, Yan Gu, Na-Na Yan, Yan-Yan Mao, Xing-Xing Zhen, Jian-Mei Wang, Jing Yang, Hui-Juan Shi, Xuan Zhang and Jian Wang
    Citation: Journal of Translational Medicine 2018 16:186
  26. We previously reported early on-treatment significant modulation in circulating regulatory T cell (Treg), myeloid derived suppressor cells (MDSC) and antigen-specific type I CD4+ and CD8+ T cells that correlat...

    Authors: Janet Retseck, Alexis Nasr, Yan Lin, Huang Lin, Prateek Mendiratta, Lisa H. Butterfield and Ahmad A. Tarhini
    Citation: Journal of Translational Medicine 2018 16:184
  27. The functions of the protein expressed in the nucleus and cytoplasm were different or opposite. The previous study found that oncogene Klf4 played a role of tumor suppressor in the nasopharyngeal cytoplasm. Cetux...

    Authors: Xiqing Li, Zunlan Zhao, Shijiang Yi, Lei Ma, Ming Li, Mingyue Liu, Yaping Zhang and Guangzhi Liu
    Citation: Journal of Translational Medicine 2018 16:183
  28. Patients with brain tumor or pancreatic cancer exhibit the poorest prognosis, while immune fitness and cellular immune exhaustion impacts their survival immensely. This work identifies differences in the immun...

    Authors: Zhenjiang Liu, Thomas Poiret, Qingda Meng, Martin Rao, Anna von Landenberg, Esther Schoutrop, Davide Valentini, Ernest Dodoo, Inti Peredo-Harvey and Markus Maeurer
    Citation: Journal of Translational Medicine 2018 16:182
  29. Circulating tumor cells (CTCs) have been suggested as potential prognostic indicators for multiple tumors, including gastric cancer; however, pre- and post-operative CTC changes in resectable gastric cancer an...

    Authors: Qiyue Zhang, Fei Shan, Ziyu Li, Jing Gao, Yilin Li, Lin Shen, Jiafu Ji and Ming Lu
    Citation: Journal of Translational Medicine 2018 16:171
  30. The carboxyl terminus of Hsc70-interacting protein (CHIP) is an E3 ubiquitin ligase that plays a controversial role in different cancers, either as a tumor suppressor or a tumor promoter. To date, the exact fu...

    Authors: Jingjing Xu, Jun Zhou, Hanjue Dai, Fei Liu, Wenjing Li, Wenjuan Wang and Feng Guo
    Citation: Journal of Translational Medicine 2018 16:169
  31. Symptomatic peripheral artery disease (PAD) is an atherosclerotic occlusive disease affecting the lower extremities. The cause of symptomatic PAD is atherosclerosis, vascular dysfunctions, impaired angiogenesi...

    Authors: Line Ea Hemstra, Anders Schlosser, Jes Sanddal Lindholt and Grith L. Sorensen
    Citation: Journal of Translational Medicine 2018 16:159
  32. Granulin epithelin precursor (GEP) is reported to function as a growth factor stimulating proliferation and migration, and conferring chemoresistance in many cancer types. However, the expression and functiona...

    Authors: Yi Pan, Siu Tim Cheung, Joanna Hung Man Tong, Ka Yee Tin, Wei Kang, Raymond Wai Ming Lung, Feng Wu, Hui Li, Simon Siu Man Ng, Tony Wing Chung Mak, Ka Fai To and Anthony Wing Hung Chan
    Citation: Journal of Translational Medicine 2018 16:150
  33. Diabetic kidney disease is a renal microvascular disease caused by diabetes, known as one of the most serious and lethal complications of diabetes. Early renal hypertrophy is the main pathological feature, whi...

    Authors: Yue Wang, Zong-ji Zheng, Yi-jie Jia, Yan-lin Yang and Yao-ming Xue
    Citation: Journal of Translational Medicine 2018 16:146
  34. Increasing studies showed that miR-200 family (miR-200s) clusters are aberrantly expressed in multiple human cancers, and miR-200s clusters function as tumor suppressor genes by affecting cell proliferation, self...

    Authors: Jing-dong Zhou, Liu-chao Zhang, Ting-juan Zhang, Yu Gu, De-hong Wu, Wei Zhang, Ji-chun Ma, Xiang-mei Wen, Hong Guo, Jiang Lin and Jun Qian
    Citation: Journal of Translational Medicine 2018 16:135
  35. Prostate cancer (PCa) is a fatal malignant tumor among males in the world and the metastasis is a leading cause for PCa death. Biomarkers are therefore urgently needed to detect PCa metastatic signature at the...

    Authors: Yuxin Lin, Feifei Chen, Li Shen, Xiaoyu Tang, Cui Du, Zhandong Sun, Huijie Ding, Jiajia Chen and Bairong Shen
    Citation: Journal of Translational Medicine 2018 16:134
  36. Cancer and coagulation activation are tightly related. The extent to which factors related to both these pathologic conditions concur to patient prognosis intensely animates the inherent research areas. The st...

    Authors: Chiara Mandoj, Laura Pizzuti, Domenico Sergi, Isabella Sperduti, Marco Mazzotta, Luigi Di Lauro, Antonella Amodio, Silvia Carpano, Anna Di Benedetto, Claudio Botti, Francesca Ferranti, Anna Antenucci, Maria Gabriella D’Alessandro, Paolo Marchetti, Silverio Tomao, Giuseppe Sanguineti…
    Citation: Journal of Translational Medicine 2018 16:129
  37. Recently, accumulating evidences have revealed that microRNA-106 (miR-106) may serve as a non-invasive and cost-effective biomarker in gastric cancer (GC) detection. However, inconsistent results have prevente...

    Authors: Qiliang Peng, Yi Shen, Kaisu Lin, Li Zou, Yuntian Shen and Yaqun Zhu
    Citation: Journal of Translational Medicine 2018 16:127
  38. Intra-tumoral heterogeneity has been recently addressed in different types of cancer, including breast cancer. A concept describing the origin of intra-tumoral heterogeneity is the cancer stem-cell hypothesis,...

    Authors: Pascale Kündig, Charlotte Giesen, Hartland Jackson, Bernd Bodenmiller, Bärbel Papassotirolopus, Sandra Nicole Freiberger, Catharine Aquino, Lennart Opitz and Zsuzsanna Varga
    Citation: Journal of Translational Medicine 2018 16:118

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:180

  39. A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in kidney tissue predicted a worse renal outcome. However, this finding must be validated in ind...

    Authors: Xiaoyan Zhang, Sufang Shi, Yan Ouyang, Meng Yang, Manman Shi, Xiaoxia Pan, Jicheng Lv, Zhaohui Wang, Hong Ren, Pingyan Shen, Weiming Wang, Hong Zhang, Jingyuan Xie and Nan Chen
    Citation: Journal of Translational Medicine 2018 16:115
  40. CA125 is a prevalently used serum biomarker for detecting ovarian cancer over the last three decades. However, it has a significant deficiency in screening for early-stage cancer. With the purpose of exploring...

    Authors: Zhuowei Gu, Yifeng He, Yue Zhang, Mo Chen, Keqi Song, Yuting Huang, Qing Li and Wen Di
    Citation: Journal of Translational Medicine 2018 16:114
  41. Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme obesity. Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors invol...

    Authors: Xin Chu, Qunyan Jin, Hui Chen, G. Craig Wood, Anthony Petrick, William Strodel, Jon Gabrielsen, Peter Benotti, Tooraj Mirshahi, David J. Carey, Christopher D. Still, Johanna K. DiStefano and Glenn S. Gerhard
    Citation: Journal of Translational Medicine 2018 16:108
  42. Human tissues are invaluable resources for researchers worldwide. Biobanks are repositories of such human tissues and can have a strategic importance for genetic research, clinical care, and future discoveries...

    Authors: Ehsan Ullah, Raghvendra Mall, Reda Rawi, Naima Moustaid-Moussa, Adeel A. Butt and Halima Bensmail
    Citation: Journal of Translational Medicine 2018 16:99

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:283

  43. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is clinically defined and characterised by persistent disabling tiredness and exertional malaise, leading to functional impairment.

    Authors: Alice M. Richardson, Don P. Lewis, Badia Kita, Helen Ludlow, Nigel P. Groome, Mark P. Hedger, David M. de Kretser and Brett A. Lidbury
    Citation: Journal of Translational Medicine 2018 16:97
  44. Urinary miRNAs may potentially serve as noninvasive biomarkers in various kidney diseases to reflect disease activity, severity and progression, especially those correlated with the pathogenesis of kidney dise...

    Authors: Changming Zhang, Shaoshan Liang, Shuiqin Cheng, Wei Li, Xia Wang, Chunxia Zheng, Caihong Zeng, Shaolin Shi, Lu Xie, Ke Zen and Zhihong Liu
    Citation: Journal of Translational Medicine 2018 16:91
  45. Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor prognosis. CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein. Recently, CD109 emerges as a potenti...

    Authors: Ruixia Qi, Fengyun Dong, Qiang Liu, Yoshiki Murakumo and Ju Liu
    Citation: Journal of Translational Medicine 2018 16:88
  46. Telocytes (TCs), a recently discovered novel type of interstitial cells, were also found in a wide variety of human and mammalian reproductive organs/tissues, including uterus, oviduct and placenta. Previously...

    Authors: Xiao-Juan Jiang, Dragos Cretoiu, Zong-Ji Shen and Xiao-Jun Yang
    Citation: Journal of Translational Medicine 2018 16:85
  47. S100A9 protein, which is recently classified as a novel damage associated molecular pattern, is released from stressed cells undergoing necrosis or secreted by living cells undergoing a stress that act as endo...

    Authors: Rui Wu, Yuhong Zhang, Yu Xiang, Yishu Tang, Fang Cui, Ju Cao, Lan Zhou, Yan You and Liang Duan
    Citation: Journal of Translational Medicine 2018 16:83
  48. Immune checkpoint inhibitors (anti-CTLA-4, anti-PD-1, or the combination) enhance anti-tumor immune responses, yielding durable clinical benefit in several cancer types, including melanoma. However, a subset o...

    Authors: Michael F. Gowen, Keith M. Giles, Danny Simpson, Jeremy Tchack, Hua Zhou, Una Moran, Zarmeena Dawood, Anna C. Pavlick, Shaohui Hu, Melissa A. Wilson, Hua Zhong, Michelle Krogsgaard, Tomas Kirchhoff and Iman Osman
    Citation: Journal of Translational Medicine 2018 16:82
  49. Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection. We analyzed the role of HI...

    Authors: Noemy Starita, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello
    Citation: Journal of Translational Medicine 2018 16:77
  50. This study addresses whether the association of adiponectin gene (ADIPOQ) variants with idiopathic recurrent pregnancy loss (RPL) is influenced by obesity.

    Authors: Maryam Dendana, Wael Bahia, Ramzi R. Finan, Mariam Al-Mutawa and Wassim Y. Almawi
    Citation: Journal of Translational Medicine 2018 16:76

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  • 2022 Citation Impact
    7.4 - 2-year Impact Factor
    6.9 - 5-year Impact Factor
    1.458 - SNIP (Source Normalized Impact per Paper)
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