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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. Papillary thyroid carcinoma (PTC), which is the most common endocrine malignancy, has been steadily increasing worldwide in incidence over the years, while mechanisms underlying the pathogenesis and diagnostic...

    Authors: Yang Liu, Ting-Yu Chen, Zhi-Yan Yang, Wei Fang, Qian Wu and Chao Zhang
    Citation: Journal of Translational Medicine 2020 18:170
  2. Studies on the early 2000s documented increasing attrition rates and duration of clinical trials, leading to a representation of a “productivity crisis” in pharmaceutical research and development (R&D). In thi...

    Authors: Fabio Pammolli, Lorenzo Righetto, Sergio Abrignani, Luca Pani, Pier Giuseppe Pelicci and Emanuele Rabosio
    Citation: Journal of Translational Medicine 2020 18:162
  3. The formal risk assessment is essential in the management of acute coronary syndrome (ACS). In this study, we develop a risk model for the prediction of 3-year mortality for Chinese ACS patients with machine l...

    Authors: Yi-ming Li, Zhuo-lun Li, Fei Chen, Qi Liu, Yong Peng and Mao Chen
    Citation: Journal of Translational Medicine 2020 18:157
  4. The statin family of drugs are safe and effective therapeutic agents for the treatment of arteriosclerotic cardiovascular disease (CVD). Due to a wide range of health benefits in addition to their cholesterol ...

    Authors: Shabnam Tahamtan, Farinaz Shirban, Mohammad Bagherniya, Thomas P. Johnston and Amirhossein Sahebkar
    Citation: Journal of Translational Medicine 2020 18:155
  5. The selection of treatment for a patient with breast cancer largely relies on the cancer subtype. However, this process is complicated by changes in tumor biology at relapse. Smoking has been identified as a r...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Rika Kouhashi, Akimichi Yabumoto, Tamami Morisaki, Hisakazu Fujita, Masatsune Shibutani, Tsutomu Takashima, Kosei Hirakawa and Masaichi Ohira
    Citation: Journal of Translational Medicine 2020 18:153
  6. Current guidelines recommend angiotensin-converting-enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) as a first-line therapy in diabetic hypertensive patients and for secondary prevention in patien...

    Authors: Yue Zhang, Xiaosong Ding, Bing Hua, Qingbo Liu, Hui Chen, Xue-Qiao Zhao, Weiping Li and Hongwei Li
    Citation: Journal of Translational Medicine 2020 18:150
  7. Given that abnormal autophagy is involved in the pathogenesis of cancers, we sought to explore the potential value of autophagy-associated genes in lung adenocarcinoma (LUAD).

    Authors: Xiaofei Wang, Shuang Yao, Zengtuan Xiao, Jialin Gong, Zuo Liu, Baoai Han and Zhenfa Zhang
    Citation: Journal of Translational Medicine 2020 18:149
  8. Chronic obstructive pulmonary disease (COPD) is a major public health problem and cause of mortality worldwide. However, COPD in the early stage is usually not recognized and diagnosed. It is necessary to esta...

    Authors: Xia Ma, Yanping Wu, Ling Zhang, Weilan Yuan, Li Yan, Sha Fan, Yunzhi Lian, Xia Zhu, Junhui Gao, Jiangman Zhao, Ping Zhang, Hui Tang and Weihua Jia
    Citation: Journal of Translational Medicine 2020 18:146
  9. Bladder cancer is the most common cancer in the urinary system and the fourth most common cancer in males. This study aimed to examine differences in the survival of bladder cancer patients of different ethnic...

    Authors: Wei Fang, Zhi-Yan Yang, Ting-Yu Chen, Xian-Feng Shen and Chao Zhang
    Citation: Journal of Translational Medicine 2020 18:145

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2020 18:486

  10. As the most common form of lymphoma, diffuse large B-cell lymphoma (DLBCL) is a clinical highly heterogeneous disease with variability in therapeutic outcomes and biological features. It is a challenge to iden...

    Authors: Jinglei Hu, Jing Xu, Muqiao Yu, Yongchao Gao, Rong Liu, Honghao Zhou and Wei Zhang
    Citation: Journal of Translational Medicine 2020 18:144
  11. Smoke inhalation injury increases overall burn mortality by up to 20 times. Current therapy remains supportive with a failure to identify an optimal or targeted treatment protocol for smoke inhalation injury. ...

    Authors: Alexandra Mercel, Nick D. Tsihlis, Rob Maile and Melina R. Kibbe
    Citation: Journal of Translational Medicine 2020 18:141
  12. The rise in incidence and mortality of gastrointestinal mixed adenoneuroendocrine carcinoma (MANEC) has not been well focused. The aim of our study was to examine epidemiological trends in incidence and incide...

    Authors: Jiakun Wang, Aoxiao He, Qian Feng, Ping Hou, Junjun Wu, Zhihao Huang, Zhouqing Xiao, Chi Sun, Wenjun Liao and Linquan Wu
    Citation: Journal of Translational Medicine 2020 18:128
  13. Research has associated human epidermal growth factor receptor (HER2) with glucose and lipid metabolism. However, the association between circulating HER2 levels and coronary artery disease (CAD) remains to be...

    Authors: Wen Jian, Chun-Mei Wei, Jia-Hui Guan, Chang-Hua Mo, Yu-Tao Xu, Wen-Bo Zheng, Lang Li and Chun Gui
    Citation: Journal of Translational Medicine 2020 18:124
  14. The performance of previously published glomerular filtration rate (GFR) estimation equations degrades when directly used in Chinese population. We incorporated more independent variables and using complicated...

    Authors: Ningshan Li, Hui Huang, Han-Zhu Qian, Peijia Liu, Hui Lu and Xun Liu
    Citation: Journal of Translational Medicine 2020 18:120
  15. Prostate cancer (PCa) is a common malignant tumor with increasing incidence and high heterogeneity among males worldwide. In the era of big data and artificial intelligence, the paradigm of biomarker discovery...

    Authors: Yuxin Lin, Xiaojun Zhao, Zhijun Miao, Zhixin Ling, Xuedong Wei, Jinxian Pu, Jianquan Hou and Bairong Shen
    Citation: Journal of Translational Medicine 2020 18:119
  16. The identity management is a central component in medical research. Patients are recruited from various sites, which requires an error tolerant record linkage method, to ensure that patients are registered onl...

    Authors: Christopher Hampf, Lars Geidel, Norman Zerbe, Martin Bialke, Dana Stahl, Arne Blumentritt, Thomas Bahls, Peter Hufnagl and Wolfgang Hoffmann
    Citation: Journal of Translational Medicine 2020 18:86
  17. Tumour cells interfere with normal immune functions by affecting the expression of some immune-related genes, which play roles in the prognosis of cancer patients. In recent years, immunotherapy for tumours ha...

    Authors: Xiaoshun Shi, Ruidong Li, Xiaoying Dong, Allen Menglin Chen, Xiguang Liu, Di Lu, Siyang Feng, He Wang and Kaican Cai
    Citation: Journal of Translational Medicine 2020 18:55
  18. Accurate lymph node metastasis (LNM) prediction in colorectal cancer (CRC) patients is of great significance for treatment decision making and prognostic evaluation. We aimed to develop and validate a clinical...

    Authors: Menglei Li, Jing Zhang, Yibo Dan, Yefeng Yao, Weixing Dai, Guoxiang Cai, Guang Yang and Tong Tong
    Citation: Journal of Translational Medicine 2020 18:46
  19. During pregnancy in humans, the physiology of the mother and foetus are finely regulated by many factors. Inappropriate regulation can result in pregnancy disorders, such as complications and foetal abnormalit...

    Authors: Haiou Yang, Qianqian Ma, Yu Wang and Zhenhua Tang
    Citation: Journal of Translational Medicine 2020 18:32
  20. A correct perception of the body image, as defined by comparison with actual anthropometric analyses, is crucial to ensure the best possible nutritional status of each individual. Bioimpedance analysis (BIA) r...

    Authors: Luciana Zaccagni, Natascia Rinaldo, Barbara Bramanti, Jessica Mongillo and Emanuela Gualdi-Russo
    Citation: Journal of Translational Medicine 2020 18:20
  21. Artificial intelligence (AI), with its seemingly limitless power, holds the promise to truly revolutionize patient healthcare. However, the discourse carried out in public does not always correlate with the ac...

    Authors: M.-C. Laï, M. Brian and M.-F. Mamzer
    Citation: Journal of Translational Medicine 2020 18:14
  22. The Spanish HIV HGM BioBank is of great relevance for basic and clinical investigation, and for those groups trying to establish large networks focused on investigation on specific clinical problems. The colle...

    Authors: Irene Consuegra Fernández, Isabel García Merino and María Ángeles Muñoz-Fernández
    Citation: Journal of Translational Medicine 2020 18:6
  23. Inflammatory bowel disease (IBD) was emerging as a worldwide epidemic disease, and the advanced therapy changed the clinical course and possibly the outcomes. Our previous study reported a higher mortality rat...

    Authors: Wei-Chen Lin, Meng-Tzu Weng, Chien-Chih Tung, Yuan-Ting Chang, Yew-Loong Leong, Yu-Ting Wang, Horng-Yuan Wang, Jau-Min Wong and Shu-Chen Wei
    Citation: Journal of Translational Medicine 2019 17:414
  24. The current study aimed to construct competing endogenous RNA (ceRNA) regulation network and develop two precision medicine predictive tools for colorectal cancer (CRC).

    Authors: Zhiqiao Zhang, Tingshan He, Liwen Huang, Yanling Ouyang, Jing Li, Yiyan Huang, Peng Wang and Jianqiang Ding
    Citation: Journal of Translational Medicine 2019 17:405
  25. Since both genomic and environmental factors are involved in obesity etiology, several studies about the influence of adiposity on both nuclear DNA and mitochondrial DNA methylation patterns have been carried ...

    Authors: Laura Bordoni, Vanessa Smerilli, Cinzia Nasuti and Rosita Gabbianelli
    Citation: Journal of Translational Medicine 2019 17:399
  26. Understanding cancer heterogeneity, its temporal evolution over time, and the outcomes of guided treatment depend on accurate data collection in a context of routine clinical care. We have developed a hospital...

    Authors: Grigory Sidorenkov, Janny Nagel, Coby Meijer, Jacko J. Duker, Harry J. M. Groen, Gyorgy B. Halmos, Maaike H. M. Oonk, Rene J. Oostergo, Bert van der Vegt, Max J. H. Witjes, Marcel Nijland, Klaas Havenga, John H. Maduro, Jourik A. Gietema and Gertruida H. de Bock
    Citation: Journal of Translational Medicine 2019 17:374
  27. Subarachnoid hemorrhage (SAH) accounts for 4.4% of cerebral vascular disease, which is one of the leading causes of death in China. Rupture of intracranial aneurysms (IAs) is the most common cause of SAH. The ...

    Authors: Haixiao Liu, Wei Guo, Sishi Xiang, Peng Hu, Feifei Sun, Junmei Gao, Xiaoyang Zhang, Ping Wang, Wenting Jing, Lei Zhang, Xinjian Yang, Chuanzhi Duan, Min He, Hongqi Zhang and Yan Qu
    Citation: Journal of Translational Medicine 2019 17:349
  28. Genomic and radiomic data integration, namely radiogenomics, can provide meaningful knowledge in cancer diagnosis, prognosis and treatment. Despite several data structures based on multi-layer architecture pro...

    Authors: Mario Zanfardino, Monica Franzese, Katia Pane, Carlo Cavaliere, Serena Monti, Giuseppina Esposito, Marco Salvatore and Marco Aiello
    Citation: Journal of Translational Medicine 2019 17:337
  29. Best vitelliform macular dystrophy (BVMD) is an autosomal dominant macular degeneration. The typical central yellowish yolk-like lesion usually appears in childhood and gradually worsens. Most cases are caused...

    Authors: Vladimir Frecer, Giancarlo Iarossi, Anna Paola Salvetti, Paolo Enrico Maltese, Giulia Delledonne, Marta Oldani, Giovanni Staurenghi, Benedetto Falsini, Angelo Maria Minnella, Lucia Ziccardi, Adriano Magli, Leonardo Colombo, Fabiana D’Esposito, Jan Miertus, Francesco Viola, Marcella Attanasio…
    Citation: Journal of Translational Medicine 2019 17:330
  30. Post-transcriptional modifications have been recently expanded with the addition of RNA editing, which is predominantly mediated by adenosine and cytidine deaminases acting on DNA and RNA. Here, we review the ...

    Authors: Theodoulakis Christofi and Apostolos Zaravinos
    Citation: Journal of Translational Medicine 2019 17:319
  31. Infertility has become a global health issue with the number of couples seeking in vitro fertilization (IVF) worldwide continuing to rise. Some couples remain childless after several IVF cycles. Women undergoi...

    Authors: Jiahui Qiu, Pingping Li, Meng Dong, Xing Xin and Jichun Tan
    Citation: Journal of Translational Medicine 2019 17:317
  32. Wearable smart watches provide large amount of real-time data on the environmental state of the users and are useful to determine risk factors for onset and progression of myopia. We aim to evaluate the effica...

    Authors: Bin Ye, Kangping Liu, Siting Cao, Padmaja Sankaridurg, Wayne Li, Mengli Luan, Bo Zhang, Jianfeng Zhu, Haidong Zou, Xun Xu and Xiangui He
    Citation: Journal of Translational Medicine 2019 17:314
  33. Estrogen receptors (ERs) are thought to play an important role in non-small cell lung cancer (NSCLC). However, the effect of ERs in NSCLC is still controversial and needs further investigation. A new considera...

    Authors: Xiujuan Gao, Yue Cai, Zhuo Wang, Wenjuan He, Sisi Cao, Rong Xu and Hui Chen
    Citation: Journal of Translational Medicine 2019 17:308
  34. Identifying how pain transitions from acute to chronic is critical in designing effective prevention and management techniques for patients’ well-being, physically, psychosocially, and financially. There is an...

    Authors: Jianzhong Su, Ying Du, Kelley Bevers, Pengcheng Xiao, John Licciardone, Marco Brotto and Robert J. Gatchel
    Citation: Journal of Translational Medicine 2019 17:306
  35. Trauma is the leading cause of mortality in humans below the age of 40. Patients injured by accidents frequently suffer severe multiple trauma, which is life-threatening and leads to death in many cases. In mu...

    Authors: Birte Weber, Ina Lackner, Melanie Haffner-Luntzer, Annette Palmer, Jochen Pressmar, Karin Scharffetter-Kochanek, Bernd Knöll, Hubert Schrezenemeier, Borna Relja and Miriam Kalbitz
    Citation: Journal of Translational Medicine 2019 17:305
  36. Emerging evidences show that microRNA (miRNA) plays an important role in many human complex diseases. However, considering the inherent time-consuming and expensive of traditional in vitro experiments, more an...

    Authors: Kai Zheng, Zhu-Hong You, Lei Wang, Yong Zhou, Li-Ping Li and Zheng-Wei Li
    Citation: Journal of Translational Medicine 2019 17:260
  37. Pooled testing, in which biological specimens from multiple subjects are combined into a testing pool and tested via a single test, is a common testing method for both surveillance and screening activities. Th...

    Authors: Ngoc T. Nguyen, Hrayer Aprahamian, Ebru K. Bish and Douglas R. Bish
    Citation: Journal of Translational Medicine 2019 17:252
  38. Drug development is currently hampered by high attrition rates; many developed treatments fail during clinical testing. Part of the attrition may be due to low animal-to-human translational success rates; so-c...

    Authors: Cathalijn H. C. Leenaars, Carien Kouwenaar, Frans R. Stafleu, André Bleich, Merel Ritskes-Hoitinga, Rob B. M. De Vries and Franck L. B. Meijboom
    Citation: Journal of Translational Medicine 2019 17:223
  39. Tumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation....

    Authors: Madhu Sudhana Saddala and Hu Huang
    Citation: Journal of Translational Medicine 2019 17:215
  40. Given the benefits of physical activity for health and survival, clinicians are seeking opportunities for cancer patients to become more active independent of rehabilitation programs that are small, time-limit...

    Authors: Catherine M. Sabiston, Angela J. Fong, Erin K. O’Loughlin and Sarkis Meterissian
    Citation: Journal of Translational Medicine 2019 17:206
  41. Serum uric acid (SUA) had been associated with incident hypertension, but it is uncertain whether and to what extent the effect of SUA is mediated by other metabolic factors.

    Authors: Zhi Cao, Yangyang Cheng, Shu Li, Hongxi Yang, Li Sun, Ying Gao, Pei Yu, Weidong Li and Yaogang Wang
    Citation: Journal of Translational Medicine 2019 17:202
  42. Lymph node status and liver metastasis (LIM) are important in determining the prognosis of early colon carcinoma. We attempted to develop and validate nomograms to predict lymph node metastasis (LNM) and LIM i...

    Authors: Yongcong Yan, Haohan Liu, Kai Mao, Mengyu Zhang, Qianlei Zhou, Wei Yu, Bingchao Shi, Jie Wang and Zhiyu Xiao
    Citation: Journal of Translational Medicine 2019 17:193
  43. The aim of the present review is to discuss how the promising field of biobanking can support health care research strategies. As the concept has evolved over time, biobanks have grown from simple biological s...

    Authors: Luigi Coppola, Alessandra Cianflone, Anna Maria Grimaldi, Mariarosaria Incoronato, Paolo Bevilacqua, Francesco Messina, Simona Baselice, Andrea Soricelli, Peppino Mirabelli and Marco Salvatore
    Citation: Journal of Translational Medicine 2019 17:172
  44. Predicting adverse drug reactions (ADRs) has become very important owing to the huge global health burden and failure of drugs. This indicates a need for prior prediction of probable ADRs in preclinical stages...

    Authors: Salma Jamal, Waseem Ali, Priya Nagpal, Sonam Grover and Abhinav Grover
    Citation: Journal of Translational Medicine 2019 17:171
  45. Compared with clinically functioning pituitary adenoma (FPA), clinically non-functioning pituitary adenoma (NFPA) lacks of detectable hypersecreting serum hormones and related symptoms which make it difficult ...

    Authors: Sen Cheng, Jiaqi Wu, Chuzhong Li, Yangfang Li, Chunhui Liu, Guilin Li, Wuju Li, Shuofeng Hu, Xiaomin Ying and Yazhuo Zhang
    Citation: Journal of Translational Medicine 2019 17:164

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