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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. From a global viewpoint, endometrial cancer belongs to the most common female cancers. Despite the heavy burden of diseases and numerous unanswered questions, no detailed pictures of the global structure of en...

    Authors: Dörthe Brüggmann, Katja Ouassou, Doris Klingelhöfer, Michael K. Bohlmann, Jenny Jaque and David A. Groneberg
    Citation: Journal of Translational Medicine 2020 18:386
  2. It often takes more than 10 years and costs more than 1 billion dollars to develop a new drug for a particular disease and bring it to the market. Drug repositioning can significantly reduce costs and time in ...

    Authors: Ghazale Fahimian, Javad Zahiri, Seyed Shahriar Arab and Reza H. Sajedi
    Citation: Journal of Translational Medicine 2020 18:375
  3. Cannabis has been documented for use in alleviating anxiety. However, certain research has also shown that it can produce feelings of anxiety, panic, paranoia and psychosis. In humans, Δ9-tetrahydrocannabinol (TH...

    Authors: Lara Sharpe, Justin Sinclair, Andrew Kramer, Michael de Manincor and Jerome Sarris
    Citation: Journal of Translational Medicine 2020 18:374
  4. Kidney transplantation is the optimal treatment to cure the patients with end-stage renal disease (ESRD). However, the infectious complication, especially pneumonia, is the main cause of mortality in the early...

    Authors: Bo Peng, Hang Gong, Han Tian, Quan Zhuang, Junhui Li, Ke Cheng and Yingzi Ming
    Citation: Journal of Translational Medicine 2020 18:370
  5. The complexities of modern biomedicine are rapidly increasing. Thus, modeling and simulation have become increasingly important as a strategy to understand and predict the trajectory of pathophysiology, diseas...

    Authors: Ahmet Erdemir, Lealem Mulugeta, Joy P. Ku, Andrew Drach, Marc Horner, Tina M. Morrison, Grace C. Y. Peng, Rajanikanth Vadigepalli, William W. Lytton and Jerry G. Myers Jr.
    Citation: Journal of Translational Medicine 2020 18:369
  6. The prediction of potential drug-target interactions (DTIs) not only provides a better comprehension of biological processes but also is critical for identifying new drugs. However, due to the disadvantages of...

    Authors: Bo-Ya Ji, Zhu-Hong You, Han-Jing Jiang, Zhen-Hao Guo and Kai Zheng
    Citation: Journal of Translational Medicine 2020 18:347
  7. Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spreads rapidly and has attracted worldwide attention.

    Authors: Shuo Jiang, Qiuyue Li, Chaoqun Li, Shanshan Liu, Xiaomeng He, Tao Wang, Hua Li, Christopher Corpe, Xiaoyan Zhang, Jianqing Xu and Jin Wang
    Citation: Journal of Translational Medicine 2020 18:345
  8. Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the first coronavirus disease 2019 (COVID-19) outbreak in China and has become a public health emergency of international concern. SARS-CoV-2 outbrea...

    Authors: Maria Pachetti, Bruna Marini, Fabiola Giudici, Francesca Benedetti, Silvia Angeletti, Massimo Ciccozzi, Claudio Masciovecchio, Rudy Ippodrino and Davide Zella
    Citation: Journal of Translational Medicine 2020 18:338
  9. Patients with severe Coronavirus Disease 2019 (COVID-19) will progress rapidly to acute respiratory failure or death. We aimed to develop a quantitative tool for early predicting mortality risk of patients wit...

    Authors: Zhihong Weng, Qiaosen Chen, Sumeng Li, Huadong Li, Qian Zhang, Sihong Lu, Li Wu, Leiqun Xiong, Bobin Mi, Di Liu, Mengji Lu, Dongliang Yang, Hongbo Jiang, Shaoping Zheng and Xin Zheng
    Citation: Journal of Translational Medicine 2020 18:328
  10. Serum cell-free DNA (cfDNA) holds promise as a non-invasive cancer biomarker. The objective of this study was to evaluate the association of cfDNA concentration with clinicopathologic variables of poor prognos...

    Authors: Gregory M. Gressel, Elaine C. Maggi, Bryan E. Harmon, Kenny Q. Ye, D. Y. S. Kuo, Siobhan M. Dolan and Cristina Montagna
    Citation: Journal of Translational Medicine 2020 18:323
  11. Endometriosis is a chronic inflammatory hormone-dependent condition associated with pelvic pain and infertility, characterized by the growth of ectopic endometrium outside the uterus. Given its still unknown e...

    Authors: Helena Malvezzi, Eliana Blini Marengo, Sérgio Podgaec and Carla de Azevedo Piccinato
    Citation: Journal of Translational Medicine 2020 18:311
  12. The severe acute respiratory syndrome virus SARS-CoV-2, a close relative of the SARS-CoV virus, is the cause of the recent COVID-19 pandemic affecting, to date, over 14 million individuals across the globe and...

    Authors: Nophar Geifman and Anthony D. Whetton
    Citation: Journal of Translational Medicine 2020 18:297
  13. The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the pandemic has now been reported on all inhabited continen...

    Authors: Syed Ovais Aftab, Muhammad Zubair Ghouri, Muhammad Umer Masood, Zeshan Haider, Zulqurnain Khan, Aftab Ahmad and Nayla Munawar
    Citation: Journal of Translational Medicine 2020 18:275
  14. Since the outbreak of coronavirus disease 2019 (COVID-19), many researchers in China have performed related clinical research. However, systematic reviews of the registered clinical trials are still lacking. T...

    Authors: Rui-fang Zhu, Yu-lu Gao, Sue-Ho Robert, Jin-ping Gao, Shi-gui Yang and Chang-tai Zhu
    Citation: Journal of Translational Medicine 2020 18:274
  15. Lung cancer (LC) remains the deadliest form of cancer globally. While surgery remains the optimal treatment strategy for individuals with early-stage LC, what the metabolic consequences are of such surgical in...

    Authors: Dawei Yang, Xiaofang Yang, Yang Li, Peige Zhao, Rao Fu, Tianying Ren, Ping Hu, Yaping Wu, Hongjun Yang and Na Guo
    Citation: Journal of Translational Medicine 2020 18:243
  16. Controversy remains whether white coat hypertension (WCH) is associated with renal prognosis in patients with chronic kidney disease (CKD).

    Authors: Qin Wang, Yu Wang, Jinwei Wang, Luxia Zhang and Ming-hui Zhao
    Citation: Journal of Translational Medicine 2020 18:238

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:282

  17. Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatmen...

    Authors: Francesco Messina, Emanuela Giombini, Chiara Agrati, Francesco Vairo, Tommaso Ascoli Bartoli, Samir Al Moghazi, Mauro Piacentini, Franco Locatelli, Gary Kobinger, Markus Maeurer, Alimuddin Zumla, Maria R. Capobianchi, Francesco Nicola Lauria and Giuseppe Ippolito
    Citation: Journal of Translational Medicine 2020 18:233
  18. Myocardial infarction (MI) is one of the most severe manifestations of coronary artery disease (CAD) and the leading cause of death from non-infectious diseases worldwide. It is known that the central componen...

    Authors: German Osmak, Natalia Baulina, Philipp Koshkin and Olga Favorova
    Citation: Journal of Translational Medicine 2020 18:231
  19. The high prevalence of mental stress induced myocardial ischemia (MSIMI) causes double risk of adverse cardiac events in patients with MSIMI. However, multiple types of mental stress, diagnostic techniques, an...

    Authors: Lijun Zhang, Yanping Bao, Xi Wang, Yuxin Zhou, Shuhui Tao, Wan Xu and Meiyan Liu
    Citation: Journal of Translational Medicine 2020 18:218
  20. The association between blood pressure change and kidney damage in patients with abnormal blood glucose remains unclear. The current study aimed to identify systolic blood pressure (SBP) trajectories among the...

    Authors: Zi-Jun Sun, Jin-Wei Wang, Dong-Yuan Chang, Shuo-Hua Chen, Hui-Fen Zhang, Shou-Ling Wu, Kevin He, Lu-Xia Zhang, Min Chen and Ming-Hui Zhao
    Citation: Journal of Translational Medicine 2020 18:194
  21. The modified Gompertz equation has been proposed to fit experimental data for direct current treated tumors when multiple-straight needle electrodes are individually inserted into the base perpendicular to the...

    Authors: Narciso Antonio Villar Goris, Jorge Luis García Rodríguez, Maraelys Morales González, Beatriz Olivares Borges, Dasha Fuentes Morales, Enaide Maine Calzado, Antonio Rafael Selva Castañeda, Leonardo Mesa Torres, Juan Ignacio Montijano, Victoriano Gustavo Sierra González, Daniel Jay Pérez, Oscar Ortiz Posada, Janet Avellanet Martínez, Arlem García Delgado, Karina García Martínez, Mayrel Labrada Mon…
    Citation: Journal of Translational Medicine 2020 18:190
  22. The prognosis of patients with advanced schistosomiasis is poor. Pre-existing prognosis studies did not differentiate the causes of the deaths. The objectives were to evaluate the 2-year overall survival (OS) ...

    Authors: Guo Li, Lifei Lian, Shanshan Huang, Jinfeng Miao, Huan Cao, Chengchao Zuo, Xiaoyan Liu and Zhou Zhu
    Citation: Journal of Translational Medicine 2020 18:187
  23. Papillary thyroid carcinoma (PTC), which is the most common endocrine malignancy, has been steadily increasing worldwide in incidence over the years, while mechanisms underlying the pathogenesis and diagnostic...

    Authors: Yang Liu, Ting-Yu Chen, Zhi-Yan Yang, Wei Fang, Qian Wu and Chao Zhang
    Citation: Journal of Translational Medicine 2020 18:170
  24. Studies on the early 2000s documented increasing attrition rates and duration of clinical trials, leading to a representation of a “productivity crisis” in pharmaceutical research and development (R&D). In thi...

    Authors: Fabio Pammolli, Lorenzo Righetto, Sergio Abrignani, Luca Pani, Pier Giuseppe Pelicci and Emanuele Rabosio
    Citation: Journal of Translational Medicine 2020 18:162
  25. The formal risk assessment is essential in the management of acute coronary syndrome (ACS). In this study, we develop a risk model for the prediction of 3-year mortality for Chinese ACS patients with machine l...

    Authors: Yi-ming Li, Zhuo-lun Li, Fei Chen, Qi Liu, Yong Peng and Mao Chen
    Citation: Journal of Translational Medicine 2020 18:157
  26. The statin family of drugs are safe and effective therapeutic agents for the treatment of arteriosclerotic cardiovascular disease (CVD). Due to a wide range of health benefits in addition to their cholesterol ...

    Authors: Shabnam Tahamtan, Farinaz Shirban, Mohammad Bagherniya, Thomas P. Johnston and Amirhossein Sahebkar
    Citation: Journal of Translational Medicine 2020 18:155
  27. The selection of treatment for a patient with breast cancer largely relies on the cancer subtype. However, this process is complicated by changes in tumor biology at relapse. Smoking has been identified as a r...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Rika Kouhashi, Akimichi Yabumoto, Tamami Morisaki, Hisakazu Fujita, Masatsune Shibutani, Tsutomu Takashima, Kosei Hirakawa and Masaichi Ohira
    Citation: Journal of Translational Medicine 2020 18:153
  28. Current guidelines recommend angiotensin-converting-enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) as a first-line therapy in diabetic hypertensive patients and for secondary prevention in patien...

    Authors: Yue Zhang, Xiaosong Ding, Bing Hua, Qingbo Liu, Hui Chen, Xue-Qiao Zhao, Weiping Li and Hongwei Li
    Citation: Journal of Translational Medicine 2020 18:150
  29. Given that abnormal autophagy is involved in the pathogenesis of cancers, we sought to explore the potential value of autophagy-associated genes in lung adenocarcinoma (LUAD).

    Authors: Xiaofei Wang, Shuang Yao, Zengtuan Xiao, Jialin Gong, Zuo Liu, Baoai Han and Zhenfa Zhang
    Citation: Journal of Translational Medicine 2020 18:149
  30. Chronic obstructive pulmonary disease (COPD) is a major public health problem and cause of mortality worldwide. However, COPD in the early stage is usually not recognized and diagnosed. It is necessary to esta...

    Authors: Xia Ma, Yanping Wu, Ling Zhang, Weilan Yuan, Li Yan, Sha Fan, Yunzhi Lian, Xia Zhu, Junhui Gao, Jiangman Zhao, Ping Zhang, Hui Tang and Weihua Jia
    Citation: Journal of Translational Medicine 2020 18:146
  31. Bladder cancer is the most common cancer in the urinary system and the fourth most common cancer in males. This study aimed to examine differences in the survival of bladder cancer patients of different ethnic...

    Authors: Wei Fang, Zhi-Yan Yang, Ting-Yu Chen, Xian-Feng Shen and Chao Zhang
    Citation: Journal of Translational Medicine 2020 18:145

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2020 18:486

  32. As the most common form of lymphoma, diffuse large B-cell lymphoma (DLBCL) is a clinical highly heterogeneous disease with variability in therapeutic outcomes and biological features. It is a challenge to iden...

    Authors: Jinglei Hu, Jing Xu, Muqiao Yu, Yongchao Gao, Rong Liu, Honghao Zhou and Wei Zhang
    Citation: Journal of Translational Medicine 2020 18:144
  33. Smoke inhalation injury increases overall burn mortality by up to 20 times. Current therapy remains supportive with a failure to identify an optimal or targeted treatment protocol for smoke inhalation injury. ...

    Authors: Alexandra Mercel, Nick D. Tsihlis, Rob Maile and Melina R. Kibbe
    Citation: Journal of Translational Medicine 2020 18:141
  34. The rise in incidence and mortality of gastrointestinal mixed adenoneuroendocrine carcinoma (MANEC) has not been well focused. The aim of our study was to examine epidemiological trends in incidence and incide...

    Authors: Jiakun Wang, Aoxiao He, Qian Feng, Ping Hou, Junjun Wu, Zhihao Huang, Zhouqing Xiao, Chi Sun, Wenjun Liao and Linquan Wu
    Citation: Journal of Translational Medicine 2020 18:128
  35. Research has associated human epidermal growth factor receptor (HER2) with glucose and lipid metabolism. However, the association between circulating HER2 levels and coronary artery disease (CAD) remains to be...

    Authors: Wen Jian, Chun-Mei Wei, Jia-Hui Guan, Chang-Hua Mo, Yu-Tao Xu, Wen-Bo Zheng, Lang Li and Chun Gui
    Citation: Journal of Translational Medicine 2020 18:124
  36. The performance of previously published glomerular filtration rate (GFR) estimation equations degrades when directly used in Chinese population. We incorporated more independent variables and using complicated...

    Authors: Ningshan Li, Hui Huang, Han-Zhu Qian, Peijia Liu, Hui Lu and Xun Liu
    Citation: Journal of Translational Medicine 2020 18:120
  37. Prostate cancer (PCa) is a common malignant tumor with increasing incidence and high heterogeneity among males worldwide. In the era of big data and artificial intelligence, the paradigm of biomarker discovery...

    Authors: Yuxin Lin, Xiaojun Zhao, Zhijun Miao, Zhixin Ling, Xuedong Wei, Jinxian Pu, Jianquan Hou and Bairong Shen
    Citation: Journal of Translational Medicine 2020 18:119
  38. The identity management is a central component in medical research. Patients are recruited from various sites, which requires an error tolerant record linkage method, to ensure that patients are registered onl...

    Authors: Christopher Hampf, Lars Geidel, Norman Zerbe, Martin Bialke, Dana Stahl, Arne Blumentritt, Thomas Bahls, Peter Hufnagl and Wolfgang Hoffmann
    Citation: Journal of Translational Medicine 2020 18:86
  39. Tumour cells interfere with normal immune functions by affecting the expression of some immune-related genes, which play roles in the prognosis of cancer patients. In recent years, immunotherapy for tumours ha...

    Authors: Xiaoshun Shi, Ruidong Li, Xiaoying Dong, Allen Menglin Chen, Xiguang Liu, Di Lu, Siyang Feng, He Wang and Kaican Cai
    Citation: Journal of Translational Medicine 2020 18:55
  40. Accurate lymph node metastasis (LNM) prediction in colorectal cancer (CRC) patients is of great significance for treatment decision making and prognostic evaluation. We aimed to develop and validate a clinical...

    Authors: Menglei Li, Jing Zhang, Yibo Dan, Yefeng Yao, Weixing Dai, Guoxiang Cai, Guang Yang and Tong Tong
    Citation: Journal of Translational Medicine 2020 18:46
  41. During pregnancy in humans, the physiology of the mother and foetus are finely regulated by many factors. Inappropriate regulation can result in pregnancy disorders, such as complications and foetal abnormalit...

    Authors: Haiou Yang, Qianqian Ma, Yu Wang and Zhenhua Tang
    Citation: Journal of Translational Medicine 2020 18:32
  42. A correct perception of the body image, as defined by comparison with actual anthropometric analyses, is crucial to ensure the best possible nutritional status of each individual. Bioimpedance analysis (BIA) r...

    Authors: Luciana Zaccagni, Natascia Rinaldo, Barbara Bramanti, Jessica Mongillo and Emanuela Gualdi-Russo
    Citation: Journal of Translational Medicine 2020 18:20
  43. Artificial intelligence (AI), with its seemingly limitless power, holds the promise to truly revolutionize patient healthcare. However, the discourse carried out in public does not always correlate with the ac...

    Authors: M.-C. Laï, M. Brian and M.-F. Mamzer
    Citation: Journal of Translational Medicine 2020 18:14
  44. The Spanish HIV HGM BioBank is of great relevance for basic and clinical investigation, and for those groups trying to establish large networks focused on investigation on specific clinical problems. The colle...

    Authors: Irene Consuegra Fernández, Isabel García Merino and María Ángeles Muñoz-Fernández
    Citation: Journal of Translational Medicine 2020 18:6
  45. Inflammatory bowel disease (IBD) was emerging as a worldwide epidemic disease, and the advanced therapy changed the clinical course and possibly the outcomes. Our previous study reported a higher mortality rat...

    Authors: Wei-Chen Lin, Meng-Tzu Weng, Chien-Chih Tung, Yuan-Ting Chang, Yew-Loong Leong, Yu-Ting Wang, Horng-Yuan Wang, Jau-Min Wong and Shu-Chen Wei
    Citation: Journal of Translational Medicine 2019 17:414
  46. The current study aimed to construct competing endogenous RNA (ceRNA) regulation network and develop two precision medicine predictive tools for colorectal cancer (CRC).

    Authors: Zhiqiao Zhang, Tingshan He, Liwen Huang, Yanling Ouyang, Jing Li, Yiyan Huang, Peng Wang and Jianqiang Ding
    Citation: Journal of Translational Medicine 2019 17:405
  47. Since both genomic and environmental factors are involved in obesity etiology, several studies about the influence of adiposity on both nuclear DNA and mitochondrial DNA methylation patterns have been carried ...

    Authors: Laura Bordoni, Vanessa Smerilli, Cinzia Nasuti and Rosita Gabbianelli
    Citation: Journal of Translational Medicine 2019 17:399

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