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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. Early prediction of acute kidney injury (AKI) after liver transplantation (LT) facilitates timely recognition and intervention. We aimed to build a risk predictor of post-LT AKI via supervised machine learning...

    Authors: Yihan Zhang, Dong Yang, Zifeng Liu, Chaojin Chen, Mian Ge, Xiang Li, Tongsen Luo, Zhengdong Wu, Chenguang Shi, Bohan Wang, Xiaoshuai Huang, Xiaodong Zhang, Shaoli Zhou and Ziqing Hei
    Citation: Journal of Translational Medicine 2021 19:321
    Content type: Research Published on:

  2. Several predictive factors for chronic kidney disease (CKD) following radical nephrectomy (RN) or partial nephrectomy (PN) have been identified. However, early postoperative laboratory values were infrequently...

    Authors: Dongwoo Chae, Na Young Kim, Ki Jun Kim, Kyemyung Park, Chaerim Oh and So Yeon Kim
    Citation: Journal of Translational Medicine 2021 19:307
    Content type: Research Published on:

  3. Immunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which is one of the important challenges. Detecting the regulation of immune cells and biomarkers concerning immune checkpoint...

    Authors: Jingwen Wang, Feng Li, Yanjun Xu, Xuan Zheng, Chunlong Zhang, Congxue Hu, Yingqi Xu, Wanqi Mi, Xia Li and Yunpeng Zhang
    Citation: Journal of Translational Medicine 2021 19:296
    Content type: Research Published on:

  4. Heart failure (HF) with preserved ejection fraction (HFpEF) is a leading cause of hospitalizations and mortality when diagnosed at the age of ≥ 65 years. HFpEF represents multifactorial and multisystemic syndr...

    Authors: Ying Lin, Shihui Fu, Yao Yao, Yulong Li, Yali Zhao and Leiming Luo
    Citation: Journal of Translational Medicine 2021 19:291
    Content type: Review Published on:

  5. We performed a prospective multicentre diagnostic study to evaluate the combined interferon-γ (IFN-γ) and interleukin-2 (IL-2) release assay for detect active pulmonary tuberculosis (TB) in China.

    Authors: Yaoju Tan, Yunhong Tan, Junlian Li, Pengnan Hu, Ping Guan, Haobin Kuang, Qide Liang, Yanyan Yu, Zhongnan Chen, Quan Wang, Zhenping Yang, DiLiNaZi AiKeReMu, Yu Pang and Jianxiong Liu
    Citation: Journal of Translational Medicine 2021 19:289
    Content type: Research Published on:

  6. This study aimed to establish and validate an easy-to-operate novel scoring system based on simple and readily available clinical indices for predicting the progression of chronic kidney disease (CKD).

    Authors: Qian Xu, Yunyun Wang, Yiqun Fang, Shanshan Feng, Cuiyun Chen and Yanxia Jiang
    Citation: Journal of Translational Medicine 2021 19:288
    Content type: Research Published on:

  7. There is a huge body of scientific literature describing the relation between tumor types and anti-cancer drugs. The vast amount of scientific literature makes it impossible for researchers and physicians to e...

    Authors: Chris Bauer, Ralf Herwig, Matthias Lienhard, Paul Prasse, Tobias Scheffer and Johannes Schuchhardt
    Citation: Journal of Translational Medicine 2021 19:274
    Content type: Research Published on:

  8. Biobanking is an area of scientific activity that is growing in strength and importance. The variety of collections combining biological samples and medical scientific information makes biobanking an indispens...

    Authors: Anna Chróścicka, Angelika Paluch, Łukasz Kozera and Małgorzata Lewandowska-Szumieł
    Citation: Journal of Translational Medicine 2021 19:267
    Content type: Research Published on:

  9. Polycystic kidney disease (PKD) is a common renal disorder affecting approximately 1 in 1000 live births. Tuberculosis (TB) is an infectious disease worldwide. This study investigated the risk of TB infection ...

    Authors: Ting-Fang Chiu, Tung-Min Yu, Chih-Wei Chiu, Brian K. Lee, Tsuo-Hung Lan, Chi-Yuan Li, Mei-Chen Lin and Chia-Hung Kao
    Citation: Journal of Translational Medicine 2021 19:253
    Content type: Research Published on:

  10. To investigate the COVID-19 pandemic related alteration of health promoting behaviour during lockdown among medical students compared to other students.

    Authors: Julius Steffen, Jenny Schlichtiger, Stefan Brunner and Bruno C. Huber
    Citation: Journal of Translational Medicine 2021 19:242
    Content type: Letter to the Editor Published on:

  11. Post-translational modification (PTM) is a biological process that alters proteins and is therefore involved in the regulation of various cellular activities and pathogenesis. Protein phosphorylation is an ess...

    Authors: Salma Jamal, Waseem Ali, Priya Nagpal, Abhinav Grover and Sonam Grover
    Citation: Journal of Translational Medicine 2021 19:218
    Content type: Research Published on:

  12. Sidedness (right/left) of colorectal cancer (CRC) is essential for treatment. Whether carcinogenesis of tobacco varies by sidedness remains unclear. The present study aims to evaluate the sidedness tendency of...

    Authors: Lu-Ping Yang, Zi-Xian Wang, Rui Zhang, Na Zhou, A-Man Wang, Wei Liang, Zhi-Qiang Wang, Hui-Yan Luo, Feng Wang, Ji-Wei Liu, Fang Liu, Xiao-Chun Zhang, Yun-Peng Liu and Ying Jin
    Citation: Journal of Translational Medicine 2021 19:150
    Content type: Research Published on:

  13. Steroid resistant (SR) nephrotic syndrome (NS) affects up to 30% of children and is responsible for fast progression to end stage renal disease. Currently there is no early prognostic marker of SR and studied ...

    Authors: Katarzyna Zaorska, Piotr Zawierucha, Monika Świerczewska, Danuta Ostalska-Nowicka, Jacek Zachwieja and Michał Nowicki
    Citation: Journal of Translational Medicine 2021 19:130
    Content type: Research Published on:

  14. Discovering potential predictive risks in the super precarcinomatous phase of hepatocellular carcinoma (HCC) without any clinical manifestations is impossible under normal paradigm but critical to control this...

    Authors: Yinying Chen, Wei Yang, Qilong Chen, Qiong Liu, Jun Liu, Yingying Zhang, Bing Li, Dongfeng Li, Jingyi Nan, Xiaodong Li, Huikun Wu, Xinghua Xiang, Yehui Peng, Jie Wang, Shibing Su and Zhong Wang
    Citation: Journal of Translational Medicine 2021 19:122
    Content type: Research Published on:

  15. The aim of the study was to systematically review relevant studies to evaluate the diagnostic value of urinary kidney injury molecule 1 (uKIM-1) for acute kidney injury (AKI) in adults.

    Authors: Jiwen Geng, Yuxuan Qiu, Zheng Qin and Baihai Su
    Citation: Journal of Translational Medicine 2021 19:105
    Content type: Review Published on:

  16. This study investigated whether maternal serum D-dimer (DD) alone or DD combined with alpha-fetoprotein (AFP) and free β-subunit of human chorionic gonadotropin (free β-hCG) in the second trimester could be us...

    Authors: Yiming Chen, Yijie Chen, Xue Wang, Xuelian Chu, Wenwen Ning, Linyuan Gu, Liyao Li, Zhen Xie and Caihe Wen
    Citation: Journal of Translational Medicine 2021 19:94
    Content type: Research Published on:

  17. tRNA-derived fragments (tRFs) are 14–40-nucleotide-long, small non-coding RNAs derived from specific tRNA cleavage events with key regulatory functions in many biological processes. Many studies have shown tha...

    Authors: Qiong Xiao, Peng Gao, Xuanzhang Huang, Xiaowan Chen, Quan Chen, Xinger Lv, Yu Fu, Yongxi Song and Zhenning Wang
    Citation: Journal of Translational Medicine 2021 19:88
    Content type: Research Published on:

  18. The 21-gene recurrence score (RS) testing can predict the prognosis for luminal breast cancer patients. Meanwhile, patients > 50 years with RS > 25 have improved survival with adjuvant chemotherapy. The curren...

    Authors: Jing Yu, Jiayi Wu, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Xiaosong Chen and Kunwei Shen
    Citation: Journal of Translational Medicine 2021 19:75
    Content type: Research Published on:

  19. Neurotrophic tropomyosin receptor kinases (NTRKs) are a gene family function as oncogene or tumor suppressor gene in distinct cancers. We aimed to investigate the methylation and expression profiles and prognosti...

    Authors: Zijian Chen, Zenghong Huang, Yanxin Luo, Qi Zou, Liangliang Bai, Guannan Tang, Xiaolin Wang, Guangwen Cao, Meijin Huang, Jun Xiang and Huichuan Yu
    Citation: Journal of Translational Medicine 2021 19:73
    Content type: Research Published on:

  20. Data analysis for biomedical research often requires a record linkage step to identify records from multiple data sources referring to the same person. Due to the lack of unique personal identifiers across the...

    Authors: Florens Rohde, Martin Franke, Ziad Sehili, Martin Lablans and Erhard Rahm
    Citation: Journal of Translational Medicine 2021 19:33
    Content type: Methodology Published on:

  22. Myopathies are a heterogenous collection of disorders characterized by dysfunction of skeletal muscle. In practice, myopathies are frequently encountered by physicians and precise diagnosis remains a challenge...

    Authors: Andrew Tran, Chris J. Walsh, Jane Batt, Claudia C. dos Santos and Pingzhao Hu
    Citation: Journal of Translational Medicine 2020 18:454
    Content type: Research Published on:

  23. Squamous cell carcinoma (SCC) is a main pathological type of non-small cell lung cancer. It is common among elderly patients with poor prognosis. We aimed to establish an accurate nomogram to predict survival ...

    Authors: Siying Chen, Chunxia Gao, Qian Du, Lina Tang, Haisheng You and Yalin Dong
    Citation: Journal of Translational Medicine 2020 18:436
    Content type: Research Published on:

  24. Metastasized clear cell renal cell carcinoma (ccRCC) is associated with a poor prognosis. Almost one-third of patients with non-metastatic tumors at diagnosis will later progress with metastatic disease. These...

    Authors: Emma Andersson-Evelönn, Linda Vidman, David Källberg, Mattias Landfors, Xijia Liu, Börje Ljungberg, Magnus Hultdin, Patrik Rydén and Sofie Degerman
    Citation: Journal of Translational Medicine 2020 18:435
    Content type: Research Published on:

  25. Clinical whole exome sequencing was introduced in an Australian centre in 2017, as an alternative to Sanger sequencing. We aimed to identify predictors of cancer physicians’ somatic mutation test ordering beha...

    Authors: Anastassia Demeshko, David J. Pennisi, Sushil Narayan, Stacy W. Gray, Matthew A. Brown and Aideen M. McInerney-Leo
    Citation: Journal of Translational Medicine 2020 18:431
    Content type: Research Published on:

  26. Iodine is an essential trace element for the production of thyroid hormones, and plays a key role during the gestational period for optimal foetal growth and (neuro-)development. To this day, iodine deficiency...

    Authors: Kristof Y. Neven, Bianca Cox, Karen Vrijens, Michelle Plusquin, Harry A. Roels, Ann Ruttens and Tim S. Nawrot
    Citation: Journal of Translational Medicine 2020 18:426
    Content type: Research Published on:

  27. Medical data from family doctors are of great importance to health care researchers but seem to be locked in German practices and, thus, are underused in research. The RADAR project (Routine Anonymized Data fo...

    Authors: Thomas Bahls, Johannes Pung, Stephanie Heinemann, Johannes Hauswaldt, Iris Demmer, Arne Blumentritt, Henriette Rau, Johannes Drepper, Philipp Wieder, Roland Groh, Eva Hummers and Falk Schlegelmilch
    Citation: Journal of Translational Medicine 2020 18:394
    Content type: Research Published on:

  28. Huntington’s disease (HD) is a neurodegenerative disorder characterized by psychiatric symptoms, serious motor and cognitive deficits. Certain pathological changes can already be observed in pre-symptomatic HD...

    Authors: Chunchen Xiang, Shengri Cong, Bin Liang and Shuyan Cong
    Citation: Journal of Translational Medicine 2020 18:388
    Content type: Research Published on:

  29. From a global viewpoint, endometrial cancer belongs to the most common female cancers. Despite the heavy burden of diseases and numerous unanswered questions, no detailed pictures of the global structure of en...

    Authors: Dörthe Brüggmann, Katja Ouassou, Doris Klingelhöfer, Michael K. Bohlmann, Jenny Jaque and David A. Groneberg
    Citation: Journal of Translational Medicine 2020 18:386
    Content type: Research Published on:

  30. It often takes more than 10 years and costs more than 1 billion dollars to develop a new drug for a particular disease and bring it to the market. Drug repositioning can significantly reduce costs and time in ...

    Authors: Ghazale Fahimian, Javad Zahiri, Seyed Shahriar Arab and Reza H. Sajedi
    Citation: Journal of Translational Medicine 2020 18:375
    Content type: Research Published on:

  31. Cannabis has been documented for use in alleviating anxiety. However, certain research has also shown that it can produce feelings of anxiety, panic, paranoia and psychosis. In humans, Δ9-tetrahydrocannabinol (TH...

    Authors: Lara Sharpe, Justin Sinclair, Andrew Kramer, Michael de Manincor and Jerome Sarris
    Citation: Journal of Translational Medicine 2020 18:374
    Content type: Research Published on:

  32. Kidney transplantation is the optimal treatment to cure the patients with end-stage renal disease (ESRD). However, the infectious complication, especially pneumonia, is the main cause of mortality in the early...

    Authors: Bo Peng, Hang Gong, Han Tian, Quan Zhuang, Junhui Li, Ke Cheng and Yingzi Ming
    Citation: Journal of Translational Medicine 2020 18:370
    Content type: Research Published on:

  33. The complexities of modern biomedicine are rapidly increasing. Thus, modeling and simulation have become increasingly important as a strategy to understand and predict the trajectory of pathophysiology, diseas...

    Authors: Ahmet Erdemir, Lealem Mulugeta, Joy P. Ku, Andrew Drach, Marc Horner, Tina M. Morrison, Grace C. Y. Peng, Rajanikanth Vadigepalli, William W. Lytton and Jerry G. Myers Jr.
    Citation: Journal of Translational Medicine 2020 18:369
    Content type: Review Published on:

  34. The prediction of potential drug-target interactions (DTIs) not only provides a better comprehension of biological processes but also is critical for identifying new drugs. However, due to the disadvantages of...

    Authors: Bo-Ya Ji, Zhu-Hong You, Han-Jing Jiang, Zhen-Hao Guo and Kai Zheng
    Citation: Journal of Translational Medicine 2020 18:347
    Content type: Research Published on:

  35. Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spreads rapidly and has attracted worldwide attention.

    Authors: Shuo Jiang, Qiuyue Li, Chaoqun Li, Shanshan Liu, Xiaomeng He, Tao Wang, Hua Li, Christopher Corpe, Xiaoyan Zhang, Jianqing Xu and Jin Wang
    Citation: Journal of Translational Medicine 2020 18:345
    Content type: Research Published on:

  36. Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the first coronavirus disease 2019 (COVID-19) outbreak in China and has become a public health emergency of international concern. SARS-CoV-2 outbrea...

    Authors: Maria Pachetti, Bruna Marini, Fabiola Giudici, Francesca Benedetti, Silvia Angeletti, Massimo Ciccozzi, Claudio Masciovecchio, Rudy Ippodrino and Davide Zella
    Citation: Journal of Translational Medicine 2020 18:338
    Content type: Research Published on:

  37. Patients with severe Coronavirus Disease 2019 (COVID-19) will progress rapidly to acute respiratory failure or death. We aimed to develop a quantitative tool for early predicting mortality risk of patients wit...

    Authors: Zhihong Weng, Qiaosen Chen, Sumeng Li, Huadong Li, Qian Zhang, Sihong Lu, Li Wu, Leiqun Xiong, Bobin Mi, Di Liu, Mengji Lu, Dongliang Yang, Hongbo Jiang, Shaoping Zheng and Xin Zheng
    Citation: Journal of Translational Medicine 2020 18:328
    Content type: Research Published on:

  38. Serum cell-free DNA (cfDNA) holds promise as a non-invasive cancer biomarker. The objective of this study was to evaluate the association of cfDNA concentration with clinicopathologic variables of poor prognos...

    Authors: Gregory M. Gressel, Elaine C. Maggi, Bryan E. Harmon, Kenny Q. Ye, D. Y. S. Kuo, Siobhan M. Dolan and Cristina Montagna
    Citation: Journal of Translational Medicine 2020 18:323
    Content type: Research Published on:

  39. Endometriosis is a chronic inflammatory hormone-dependent condition associated with pelvic pain and infertility, characterized by the growth of ectopic endometrium outside the uterus. Given its still unknown e...

    Authors: Helena Malvezzi, Eliana Blini Marengo, Sérgio Podgaec and Carla de Azevedo Piccinato
    Citation: Journal of Translational Medicine 2020 18:311
    Content type: Review Published on:

  41. The severe acute respiratory syndrome virus SARS-CoV-2, a close relative of the SARS-CoV virus, is the cause of the recent COVID-19 pandemic affecting, to date, over 14 million individuals across the globe and...

    Authors: Nophar Geifman and Anthony D. Whetton
    Citation: Journal of Translational Medicine 2020 18:297
    Content type: Research Published on:

  42. The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the pandemic has now been reported on all inhabited continen...

    Authors: Syed Ovais Aftab, Muhammad Zubair Ghouri, Muhammad Umer Masood, Zeshan Haider, Zulqurnain Khan, Aftab Ahmad and Nayla Munawar
    Citation: Journal of Translational Medicine 2020 18:275
    Content type: Research Published on:

  43. Since the outbreak of coronavirus disease 2019 (COVID-19), many researchers in China have performed related clinical research. However, systematic reviews of the registered clinical trials are still lacking. T...

    Authors: Rui-fang Zhu, Yu-lu Gao, Sue-Ho Robert, Jin-ping Gao, Shi-gui Yang and Chang-tai Zhu
    Citation: Journal of Translational Medicine 2020 18:274
    Content type: Review Published on:

  44. Lung cancer (LC) remains the deadliest form of cancer globally. While surgery remains the optimal treatment strategy for individuals with early-stage LC, what the metabolic consequences are of such surgical in...

    Authors: Dawei Yang, Xiaofang Yang, Yang Li, Peige Zhao, Rao Fu, Tianying Ren, Ping Hu, Yaping Wu, Hongjun Yang and Na Guo
    Citation: Journal of Translational Medicine 2020 18:243
    Content type: Research Published on:

  45. Controversy remains whether white coat hypertension (WCH) is associated with renal prognosis in patients with chronic kidney disease (CKD).

    Authors: Qin Wang, Yu Wang, Jinwei Wang, Luxia Zhang and Ming-hui Zhao
    Citation: Journal of Translational Medicine 2020 18:238
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:282

  46. Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatmen...

    Authors: Francesco Messina, Emanuela Giombini, Chiara Agrati, Francesco Vairo, Tommaso Ascoli Bartoli, Samir Al Moghazi, Mauro Piacentini, Franco Locatelli, Gary Kobinger, Markus Maeurer, Alimuddin Zumla, Maria R. Capobianchi, Francesco Nicola Lauria and Giuseppe Ippolito
    Citation: Journal of Translational Medicine 2020 18:233
    Content type: Research Published on:

  47. Myocardial infarction (MI) is one of the most severe manifestations of coronary artery disease (CAD) and the leading cause of death from non-infectious diseases worldwide. It is known that the central componen...

    Authors: German Osmak, Natalia Baulina, Philipp Koshkin and Olga Favorova
    Citation: Journal of Translational Medicine 2020 18:231
    Content type: Research Published on:

  48. The high prevalence of mental stress induced myocardial ischemia (MSIMI) causes double risk of adverse cardiac events in patients with MSIMI. However, multiple types of mental stress, diagnostic techniques, an...

    Authors: Lijun Zhang, Yanping Bao, Xi Wang, Yuxin Zhou, Shuhui Tao, Wan Xu and Meiyan Liu
    Citation: Journal of Translational Medicine 2020 18:218
    Content type: Research Published on:

  49. The association between blood pressure change and kidney damage in patients with abnormal blood glucose remains unclear. The current study aimed to identify systolic blood pressure (SBP) trajectories among the...

    Authors: Zi-Jun Sun, Jin-Wei Wang, Dong-Yuan Chang, Shuo-Hua Chen, Hui-Fen Zhang, Shou-Ling Wu, Kevin He, Lu-Xia Zhang, Min Chen and Ming-Hui Zhao
    Citation: Journal of Translational Medicine 2020 18:194
    Content type: Research Published on:

  50. The modified Gompertz equation has been proposed to fit experimental data for direct current treated tumors when multiple-straight needle electrodes are individually inserted into the base perpendicular to the...

    Authors: Narciso Antonio Villar Goris, Jorge Luis García Rodríguez, Maraelys Morales González, Beatriz Olivares Borges, Dasha Fuentes Morales, Enaide Maine Calzado, Antonio Rafael Selva Castañeda, Leonardo Mesa Torres, Juan Ignacio Montijano, Victoriano Gustavo Sierra González, Daniel Jay Pérez, Oscar Ortiz Posada, Janet Avellanet Martínez, Arlem García Delgado, Karina García Martínez, Mayrel Labrada Mon…
    Citation: Journal of Translational Medicine 2020 18:190
    Content type: Research Published on:
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