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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al

The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. Determining the risk of Cardiovascular Disease (CVD) is a necessity for timely preventive interventions in high-risk groups. However, laboratory testing may be impractical in countries with limited resources. ...

    Authors: Fatemeh Rezaei, Mozhgan Seif, Abdullah Gandomkar, Mohammad Reza Fattahi, Fatemeh Malekzadeh, Sadaf G. Sepanlou and Jafar Hasanzadeh
    Citation: Journal of Translational Medicine 2022 20:133
  2. Safety, tolerability and efficacy of granulocyte colony-stimulating factor (G-CSF) for mobilization of hematopoietic stem and progenitor cells (HSPCs) from healthy donors have been conclusively demonstrated. T...

    Authors: J. Heyn, S. Bräuninger, M. Dimova-Dobreva, N. Mathieson, N. Koptelova, A. Kolpakova, C. Seidl, P. Reinhardt, C. Tsamadou, H. Schrezenmeier, R. Nakov, E. Seifried and H. Bonig
    Citation: Journal of Translational Medicine 2022 20:121
  3. Frailty, determined by the Canadian Study of Health and Aging-Clinical Frailty Scale (CFS), is strongly associated with clinical outcomes including mortality in patients with COVID-19. However, the relationshi...

    Authors: Josh McGovern, Yassir Al-Azzawi, Olivia Kemp, Peter Moffitt, Conor Richards, Ross D. Dolan, Barry J. Laird, Donald C. McMillan and Donogh Maguire
    Citation: Journal of Translational Medicine 2022 20:98
  4. The number of elderly patients with early renal cell carcinoma (RCC) is on the rise. However, there is still a lack of accurate prediction models for the prognosis of early RCC in elderly patients. It is neces...

    Authors: Jinkui Wang, Jie Tang, Tiaoyao Chen, Song Yue, Wanting Fu, Zulong Xie and Xiaozhu Liu
    Citation: Journal of Translational Medicine 2022 20:90
  5. Epithelial–mesenchymal transition (EMT) is a dynamic and complex cellular process that is known to be hijacked by cancer cells to facilitate invasion, metastasis and therapeutic resistance. Several quantitativ...

    Authors: Ankit P. Jain, Janani Sambath, Gajanan Sathe, Irene A. George, Akhilesh Pandey, Erik W. Thompson and Prashant Kumar
    Citation: Journal of Translational Medicine 2022 20:84
  6. Chinese herbal medicine is made up of hundreds of natural drug molecules and has played a major role in traditional Chinese medicine (TCM) for several thousand years. Therefore, it is of great significance to ...

    Authors: Pengcheng Zhao, Lin Lin, Mozheng Wu, Lili Wang, Qi Geng, Li Li, Ning Zhao, Jianyu Shi and Cheng Lu
    Citation: Journal of Translational Medicine 2022 20:67
  7. Approximately 40% of persons with inflammatory bowel disease (IBD) experience psychiatric comorbidities (PC). Previous studies demonstrated the polygenetic effect on both IBD and PC. In this study, we evaluate...

    Authors: Yao Li, Charles N. Bernstein, Wei Xu and Pingzhao Hu
    Citation: Journal of Translational Medicine 2022 20:43
  8. A fraction of patients referred for complex molecular profiling of biopsied tumors may harbor germline variants in genes associated with the development of hereditary cancer syndromes (HCS). Neither the bioinf...

    Authors: Alexandra Lebedeva, Yulia Shaykhutdinova, Daria Seriak, Ekaterina Ignatova, Ekaterina Rozhavskaya, Divyasphoorthi Vardhan, Sofia Manicka, Margarita Sharova, Tatiana Grigoreva, Ancha Baranova, Vladislav Mileyko and Maxim Ivanov
    Citation: Journal of Translational Medicine 2022 20:29
  9. Sepsis is the leading cause of death in the intensive care unit (ICU). Expediting its diagnosis, largely determined by clinical assessment, improves survival. Predictive and explanatory modelling of sepsis in ...

    Authors: Holger A. Lindner, Shigehiko Schamoni, Thomas Kirschning, Corinna Worm, Bianka Hahn, Franz-Simon Centner, Jochen J. Schoettler, Michael Hagmann, Jörg Krebs, Dennis Mangold, Stephanie Nitsch, Stefan Riezler, Manfred Thiel and Verena Schneider-Lindner
    Citation: Journal of Translational Medicine 2022 20:27
  10. We aimed to compare cardiovascular risks among participants with T2DM with and without subsequent HTN and participants with HTN with and without subsequent T2DM.

    Authors: Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu and Chii-Min Hwu
    Citation: Journal of Translational Medicine 2022 20:9
  11. People with liver disease are at increased risk of developing cardiovascular disease (CVD), however, there has yet been an investigation of incidence burden, risk, and premature mortality across a wide range o...

    Authors: Wai Hoong Chang, Stefanie H. Mueller, Sheng-Chia Chung, Graham R. Foster and Alvina G. Lai
    Citation: Journal of Translational Medicine 2022 20:2
  12. The current guidelines of the American Joint Committee on Cancer (AJCC) for the staging of exocrine pancreatic tumors seem inapplicable to malignant pancreatic intraductal papillary mucinous neoplasms (IPMN). ...

    Authors: Haoxiang Zhang, Chenggang Gao, Jiaoshun Chen, Shihong Wu, Jianwei Bai and Tao Yin
    Citation: Journal of Translational Medicine 2021 19:525
  13. Association between blood pressure (BP) and kidney function among the middle and old aged general population without hypertension remains unclear.

    Authors: Huai-yu Wang, Qinqin Meng, Chao Yang, Yafeng Wang, Guilan Kong, Yaohui Zhao, Fang Wang and Luxia Zhang
    Citation: Journal of Translational Medicine 2021 19:512
  14. Cancer is one of the most serious diseases threatening human health. Cancer immunotherapy represents the most promising treatment strategy due to its high efficacy and selectivity and lower side effects compar...

    Authors: Shihu Jiao, Quan Zou, Huannan Guo and Lei Shi
    Citation: Journal of Translational Medicine 2021 19:449
  15. High morbidity and mortality due to carbapenem-resistant Gram-negative bacilli (CR-GNB) has led to the resurgence of polymyxin B (PMB) use in the last decade. The aim of our multicenter, real-world study was t...

    Authors: Xiaojuan Zhang, Shaoyan Qi, Xiaoguang Duan, Bing Han, Shuguang Zhang, Shaohua Liu, Haixu Wang, Haibo Zhang and Tongwen Sun
    Citation: Journal of Translational Medicine 2021 19:431
  16. The association between exposure to air pollution and sudden sensorineural hearing loss (SSNHL) has not been extensively discussed in the literature. Therefore, we conducted this nationwide study to evaluate t...

    Authors: Stella Chin-Shaw Tsai, Yi-Chao Hsu, Jung-Nien Lai, Ruey-Hwang Chou, Hueng-Chuen Fan, Frank Cheau-Feng Lin, Ruihong Zhang, Cheng-Li Lin and Kuang-Hsi Chang
    Citation: Journal of Translational Medicine 2021 19:424
  17. The Wnt signaling pathway is core to the growth of bladder tumors. Epithelial-to-mesenchymal transition (EMT) is significant for bladder tumor metastasis. Nevertheless, the relationship between the Wnt signali...

    Authors: Siqing Sun, Yutao Wang, Jianfeng Wang and Jianbin Bi
    Citation: Journal of Translational Medicine 2021 19:409
  18. The molecular profiling of glioblastoma (GBM) based on transcriptomic analysis could provide precise treatment and prognosis. However, current subtyping (classic, mesenchymal, neural, proneural) is time-consum...

    Authors: Minjie Fu, Jinsen Zhang, Weifeng Li, Shan He, Jingwen Zhang, Daniel Tennant, Wei Hua and Ying Mao
    Citation: Journal of Translational Medicine 2021 19:404
  19. Sjogren’s syndrome (SS) is a heterogenous disease with various phenotypes. We aimed to provide a relevant subclassification based on symptom-based clustering for patients with primary (p) SS.

    Authors: Jennifer Jooha Lee, Young Jae Park, Misun Park, Hyeon Woo Yim, Sung Hwan Park and Seung-Ki Kwok
    Citation: Journal of Translational Medicine 2021 19:394
  20. COVID-19 remains globally a highly infectious disease targeting multiple organs. Rehabilitation is increasingly valued among the supportive care fields to combat COVID-19 as currently definitive curative treat...

    Authors: Chaoran Yu and Ernest Johann Helwig
    Citation: Journal of Translational Medicine 2021 19:376
  21. The prevalence of chronic pain conditions is growing. Low back pain was the primary cause of disability worldwide out of 156 conditions assessed between 1990 and 2016, according to the Global Burden of Disease...

    Authors: Daniel I. Rhon, Julie M. Fritz, Tina A. Greenlee, Katie E. Dry, Rachel J. Mayhew, Mary C. Laugesen, Edita Dragusin and Deydre S. Teyhen
    Citation: Journal of Translational Medicine 2021 19:357
  22. Pancreatic cancer is a fatal malignancy of the digestive system and the 5-year survival rate remains low. Therefore, new molecular therapeutic targets are required to improve treatments, prognosis, and the sur...

    Authors: Juan Zeng, Heying Zhang, Yonggang Tan, Zhe Wang, Yunwei Li and Xianghong Yang
    Citation: Journal of Translational Medicine 2021 19:323
  23. Early prediction of acute kidney injury (AKI) after liver transplantation (LT) facilitates timely recognition and intervention. We aimed to build a risk predictor of post-LT AKI via supervised machine learning...

    Authors: Yihan Zhang, Dong Yang, Zifeng Liu, Chaojin Chen, Mian Ge, Xiang Li, Tongsen Luo, Zhengdong Wu, Chenguang Shi, Bohan Wang, Xiaoshuai Huang, Xiaodong Zhang, Shaoli Zhou and Ziqing Hei
    Citation: Journal of Translational Medicine 2021 19:321
  24. Several predictive factors for chronic kidney disease (CKD) following radical nephrectomy (RN) or partial nephrectomy (PN) have been identified. However, early postoperative laboratory values were infrequently...

    Authors: Dongwoo Chae, Na Young Kim, Ki Jun Kim, Kyemyung Park, Chaerim Oh and So Yeon Kim
    Citation: Journal of Translational Medicine 2021 19:307
  25. Immunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which is one of the important challenges. Detecting the regulation of immune cells and biomarkers concerning immune checkpoint...

    Authors: Jingwen Wang, Feng Li, Yanjun Xu, Xuan Zheng, Chunlong Zhang, Congxue Hu, Yingqi Xu, Wanqi Mi, Xia Li and Yunpeng Zhang
    Citation: Journal of Translational Medicine 2021 19:296
  26. Heart failure (HF) with preserved ejection fraction (HFpEF) is a leading cause of hospitalizations and mortality when diagnosed at the age of ≥ 65 years. HFpEF represents multifactorial and multisystemic syndr...

    Authors: Ying Lin, Shihui Fu, Yao Yao, Yulong Li, Yali Zhao and Leiming Luo
    Citation: Journal of Translational Medicine 2021 19:291
  27. We performed a prospective multicentre diagnostic study to evaluate the combined interferon-γ (IFN-γ) and interleukin-2 (IL-2) release assay for detect active pulmonary tuberculosis (TB) in China.

    Authors: Yaoju Tan, Yunhong Tan, Junlian Li, Pengnan Hu, Ping Guan, Haobin Kuang, Qide Liang, Yanyan Yu, Zhongnan Chen, Quan Wang, Zhenping Yang, DiLiNaZi AiKeReMu, Yu Pang and Jianxiong Liu
    Citation: Journal of Translational Medicine 2021 19:289
  28. This study aimed to establish and validate an easy-to-operate novel scoring system based on simple and readily available clinical indices for predicting the progression of chronic kidney disease (CKD).

    Authors: Qian Xu, Yunyun Wang, Yiqun Fang, Shanshan Feng, Cuiyun Chen and Yanxia Jiang
    Citation: Journal of Translational Medicine 2021 19:288
  29. There is a huge body of scientific literature describing the relation between tumor types and anti-cancer drugs. The vast amount of scientific literature makes it impossible for researchers and physicians to e...

    Authors: Chris Bauer, Ralf Herwig, Matthias Lienhard, Paul Prasse, Tobias Scheffer and Johannes Schuchhardt
    Citation: Journal of Translational Medicine 2021 19:274
  30. Biobanking is an area of scientific activity that is growing in strength and importance. The variety of collections combining biological samples and medical scientific information makes biobanking an indispens...

    Authors: Anna Chróścicka, Angelika Paluch, Łukasz Kozera and Małgorzata Lewandowska-Szumieł
    Citation: Journal of Translational Medicine 2021 19:267
  31. Polycystic kidney disease (PKD) is a common renal disorder affecting approximately 1 in 1000 live births. Tuberculosis (TB) is an infectious disease worldwide. This study investigated the risk of TB infection ...

    Authors: Ting-Fang Chiu, Tung-Min Yu, Chih-Wei Chiu, Brian K. Lee, Tsuo-Hung Lan, Chi-Yuan Li, Mei-Chen Lin and Chia-Hung Kao
    Citation: Journal of Translational Medicine 2021 19:253
  32. To investigate the COVID-19 pandemic related alteration of health promoting behaviour during lockdown among medical students compared to other students.

    Authors: Julius Steffen, Jenny Schlichtiger, Stefan Brunner and Bruno C. Huber
    Citation: Journal of Translational Medicine 2021 19:242
  33. Post-translational modification (PTM) is a biological process that alters proteins and is therefore involved in the regulation of various cellular activities and pathogenesis. Protein phosphorylation is an ess...

    Authors: Salma Jamal, Waseem Ali, Priya Nagpal, Abhinav Grover and Sonam Grover
    Citation: Journal of Translational Medicine 2021 19:218
  34. Sidedness (right/left) of colorectal cancer (CRC) is essential for treatment. Whether carcinogenesis of tobacco varies by sidedness remains unclear. The present study aims to evaluate the sidedness tendency of...

    Authors: Lu-Ping Yang, Zi-Xian Wang, Rui Zhang, Na Zhou, A-Man Wang, Wei Liang, Zhi-Qiang Wang, Hui-Yan Luo, Feng Wang, Ji-Wei Liu, Fang Liu, Xiao-Chun Zhang, Yun-Peng Liu and Ying Jin
    Citation: Journal of Translational Medicine 2021 19:150
  35. Steroid resistant (SR) nephrotic syndrome (NS) affects up to 30% of children and is responsible for fast progression to end stage renal disease. Currently there is no early prognostic marker of SR and studied ...

    Authors: Katarzyna Zaorska, Piotr Zawierucha, Monika Świerczewska, Danuta Ostalska-Nowicka, Jacek Zachwieja and Michał Nowicki
    Citation: Journal of Translational Medicine 2021 19:130
  36. Discovering potential predictive risks in the super precarcinomatous phase of hepatocellular carcinoma (HCC) without any clinical manifestations is impossible under normal paradigm but critical to control this...

    Authors: Yinying Chen, Wei Yang, Qilong Chen, Qiong Liu, Jun Liu, Yingying Zhang, Bing Li, Dongfeng Li, Jingyi Nan, Xiaodong Li, Huikun Wu, Xinghua Xiang, Yehui Peng, Jie Wang, Shibing Su and Zhong Wang
    Citation: Journal of Translational Medicine 2021 19:122
  37. The aim of the study was to systematically review relevant studies to evaluate the diagnostic value of urinary kidney injury molecule 1 (uKIM-1) for acute kidney injury (AKI) in adults.

    Authors: Jiwen Geng, Yuxuan Qiu, Zheng Qin and Baihai Su
    Citation: Journal of Translational Medicine 2021 19:105
  38. This study investigated whether maternal serum D-dimer (DD) alone or DD combined with alpha-fetoprotein (AFP) and free β-subunit of human chorionic gonadotropin (free β-hCG) in the second trimester could be us...

    Authors: Yiming Chen, Yijie Chen, Xue Wang, Xuelian Chu, Wenwen Ning, Linyuan Gu, Liyao Li, Zhen Xie and Caihe Wen
    Citation: Journal of Translational Medicine 2021 19:94
  39. tRNA-derived fragments (tRFs) are 14–40-nucleotide-long, small non-coding RNAs derived from specific tRNA cleavage events with key regulatory functions in many biological processes. Many studies have shown tha...

    Authors: Qiong Xiao, Peng Gao, Xuanzhang Huang, Xiaowan Chen, Quan Chen, Xinger Lv, Yu Fu, Yongxi Song and Zhenning Wang
    Citation: Journal of Translational Medicine 2021 19:88
  40. The 21-gene recurrence score (RS) testing can predict the prognosis for luminal breast cancer patients. Meanwhile, patients > 50 years with RS > 25 have improved survival with adjuvant chemotherapy. The curren...

    Authors: Jing Yu, Jiayi Wu, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Xiaosong Chen and Kunwei Shen
    Citation: Journal of Translational Medicine 2021 19:75
  41. Neurotrophic tropomyosin receptor kinases (NTRKs) are a gene family function as oncogene or tumor suppressor gene in distinct cancers. We aimed to investigate the methylation and expression profiles and prognosti...

    Authors: Zijian Chen, Zenghong Huang, Yanxin Luo, Qi Zou, Liangliang Bai, Guannan Tang, Xiaolin Wang, Guangwen Cao, Meijin Huang, Jun Xiang and Huichuan Yu
    Citation: Journal of Translational Medicine 2021 19:73
  42. Data analysis for biomedical research often requires a record linkage step to identify records from multiple data sources referring to the same person. Due to the lack of unique personal identifiers across the...

    Authors: Florens Rohde, Martin Franke, Ziad Sehili, Martin Lablans and Erhard Rahm
    Citation: Journal of Translational Medicine 2021 19:33
  43. Myopathies are a heterogenous collection of disorders characterized by dysfunction of skeletal muscle. In practice, myopathies are frequently encountered by physicians and precise diagnosis remains a challenge...

    Authors: Andrew Tran, Chris J. Walsh, Jane Batt, Claudia C. dos Santos and Pingzhao Hu
    Citation: Journal of Translational Medicine 2020 18:454
  44. Squamous cell carcinoma (SCC) is a main pathological type of non-small cell lung cancer. It is common among elderly patients with poor prognosis. We aimed to establish an accurate nomogram to predict survival ...

    Authors: Siying Chen, Chunxia Gao, Qian Du, Lina Tang, Haisheng You and Yalin Dong
    Citation: Journal of Translational Medicine 2020 18:436
  45. Metastasized clear cell renal cell carcinoma (ccRCC) is associated with a poor prognosis. Almost one-third of patients with non-metastatic tumors at diagnosis will later progress with metastatic disease. These...

    Authors: Emma Andersson-Evelönn, Linda Vidman, David Källberg, Mattias Landfors, Xijia Liu, Börje Ljungberg, Magnus Hultdin, Patrik Rydén and Sofie Degerman
    Citation: Journal of Translational Medicine 2020 18:435
  46. Clinical whole exome sequencing was introduced in an Australian centre in 2017, as an alternative to Sanger sequencing. We aimed to identify predictors of cancer physicians’ somatic mutation test ordering beha...

    Authors: Anastassia Demeshko, David J. Pennisi, Sushil Narayan, Stacy W. Gray, Matthew A. Brown and Aideen M. McInerney-Leo
    Citation: Journal of Translational Medicine 2020 18:431
  47. Iodine is an essential trace element for the production of thyroid hormones, and plays a key role during the gestational period for optimal foetal growth and (neuro-)development. To this day, iodine deficiency...

    Authors: Kristof Y. Neven, Bianca Cox, Karen Vrijens, Michelle Plusquin, Harry A. Roels, Ann Ruttens and Tim S. Nawrot
    Citation: Journal of Translational Medicine 2020 18:426
  48. Medical data from family doctors are of great importance to health care researchers but seem to be locked in German practices and, thus, are underused in research. The RADAR project (Routine Anonymized Data fo...

    Authors: Thomas Bahls, Johannes Pung, Stephanie Heinemann, Johannes Hauswaldt, Iris Demmer, Arne Blumentritt, Henriette Rau, Johannes Drepper, Philipp Wieder, Roland Groh, Eva Hummers and Falk Schlegelmilch
    Citation: Journal of Translational Medicine 2020 18:394
  49. Huntington’s disease (HD) is a neurodegenerative disorder characterized by psychiatric symptoms, serious motor and cognitive deficits. Certain pathological changes can already be observed in pre-symptomatic HD...

    Authors: Chunchen Xiang, Shengri Cong, Bin Liang and Shuyan Cong
    Citation: Journal of Translational Medicine 2020 18:388

Annual Journal Metrics

  • 2022 Citation Impact
    7.4 - 2-year Impact Factor
    6.9 - 5-year Impact Factor
    1.458 - SNIP (Source Normalized Impact per Paper)
    1.544 - SJR (SCImago Journal Rank)

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    10 days submission to first editorial decision for all manuscripts (Median)
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