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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. Ophthalmic epidemiology is concerned with the prevalence, distribution and other factors relating to human eye disease. While observational studies cannot avoid confounding factors from interventions, human ey...

    Authors: Jiaxin Li, Cong Li, Yu Huang, Peng Guan, Desheng Huang, Honghua Yu, Xiaohong Yang and Lei Liu
    Citation: Journal of Translational Medicine 2022 20:621
    Content type: Review Published on:

  2. Bloodstream infection (BSI) is a significant cause of mortality among patients with fever of unknown origin (FUO). Inappropriate empiric antimicrobial therapy increases difficulty in BSI diagnosis and treatmen...

    Authors: Teng Xu, Shi Wu, Jingwen Li, Li Wang and Haihui Huang
    Citation: Journal of Translational Medicine 2022 20:575
    Content type: Research Published on:

  3. In observational studies, testosterone has been reported to be associated with some types of cancers. However, the direction and magnitude of the causal association between testosterone and different types of ...

    Authors: Junke Chang, Yongming Wu, Sicheng Zhou, Ye Tian, Yan Wang, Jie Tian, Wenpeng Song, Yinxian Dong, Jue Li, Ziyi Zhao and Guowei Che
    Citation: Journal of Translational Medicine 2022 20:573
    Content type: Research Published on:

  4. The coronavirus disease 2019 (COVID-19) severely hindered the timely receipt of health care for patients with cancer, especially female patients. Depression and anxiety were more pronounced in female patients ...

    Authors: Yu Min, Zheran Liu, Rendong Huang, Ruidan Li, Jing Jin, Zhigong Wei, Ling He, Yiyan Pei, Ning Li, Yongllin Su, Xiaolin Hu and Xingchen Peng
    Citation: Journal of Translational Medicine 2022 20:560
    Content type: Research Published on:

  5. Associations of drugs with diseases provide important information for expediting drug development. Due to the number of known drug-disease associations is still insufficient, and considering that inferring ass...

    Authors: Mei-Neng Wang, Xue-Jun Xie, Zhu-Hong You, De-Wu Ding and Leon Wong
    Citation: Journal of Translational Medicine 2022 20:552
    Content type: Research Published on:

  6. Gene editing has great potential in treating diseases caused by well-characterized molecular alterations. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associate...

    Authors: Ajaz A. Bhat, Sabah Nisar, Soumi Mukherjee, Nirmalya Saha, Nageswari Yarravarapu, Saife N. Lone, Tariq Masoodi, Ravi Chauhan, Selma Maacha, Puneet Bagga, Punita Dhawan, Ammira Al-Shabeeb Akil, Wael El-Rifai, Shahab Uddin, Ravinder Reddy, Mayank Singh…
    Citation: Journal of Translational Medicine 2022 20:534
    Content type: Review Published on:

  7. Despite a recent increase in the number of RNA-seq datasets investigating heart failure (HF), accessibility and usability remain critical issues for medical researchers. We address the need for an intuitive an...

    Authors: Thiago Britto-Borges, Annekathrin Ludt, Etienne Boileau, Enio Gjerga, Federico Marini and Christoph Dieterich
    Citation: Journal of Translational Medicine 2022 20:513
    Content type: Research Published on:

  8. The low number of patients suffering from any given rare diseases poses a difficult problem for medical research: With the exception of some specialized biobanks and disease registries, potential study partici...

    Authors: Tobias Kussel, Torben Brenner, Galina Tremper, Josef Schepers, Martin Lablans and Kay Hamacher
    Citation: Journal of Translational Medicine 2022 20:458
    Content type: Research Published on:

  9. With the development of digital pathology and the renewal of deep learning algorithm, artificial intelligence (AI) is widely applied in tumor pathology. Previous researches have demonstrated that AI-based tumo...

    Authors: Zefeng Shen, Jintao Hu, Haiyang Wu, Zeshi Chen, Weixia Wu, Junyi Lin, Zixin Xu, Jianqiu Kong and Tianxin Lin
    Citation: Journal of Translational Medicine 2022 20:409
    Content type: Research Published on:

  10. Second primary malignancy (SPM) represents the leading long-term cause of death among patients with index head and neck squamous cell carcinoma (HNSCC). We aimed to quantify the association between postoperati...

    Authors: Xiaoke Zhu, Jian Zhou, Liang Zhou, Ming Zhang, Chunli Gao and Lei Tao
    Citation: Journal of Translational Medicine 2022 20:405
    Content type: Research Published on:

  11. The immune system plays a vital role in the pathological process of ischaemic stroke. However, the exact immune-related mechanism remains unclear. The current research aimed to identify immune-related key gene...

    Authors: Peng-Fei Zheng, Lu-Zhu Chen, Peng Liu, Hong Wei Pan, Wen-Juan Fan and Zheng-Yu Liu
    Citation: Journal of Translational Medicine 2022 20:361
    Content type: Research Published on:

  12. The current study aimed to construct a novel cancer artificial intelligence survival analysis system for predicting the individual mortality risk curves for cervical carcinoma patients receiving different trea...

    Authors: Jieyi Liang, Tingshan He, Hong Li, Xueqing Guo and Zhiqiao Zhang
    Citation: Journal of Translational Medicine 2022 20:293
    Content type: Research Published on:

  13. Sepsis is a life-threatening syndrome eliciting highly heterogeneous host responses. Current prognostic evaluation methods used in clinical practice are characterized by an inadequate effectiveness in predicti...

    Authors: Fei Guo, Xishun Zhu, Zhiheng Wu, Li Zhu, Jianhua Wu and Fan Zhang
    Citation: Journal of Translational Medicine 2022 20:265
    Content type: Research Published on:

  14. Previous studies demonstrated a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations also emerged, and the nature of such relationship ...

    Authors: Meng Zhang, Jiahao Qiao, Shuo Zhang and Ping Zeng
    Citation: Journal of Translational Medicine 2022 20:227
    Content type: Research Published on:

  15. While ondansetron (OND) is widespread availability, the contribution of OND to improve patient outcomes among intensive care unit (ICU) patients has not been examined. This study aimed to illustrate the associ...

    Authors: Yingying Fang, Chao Xiong and Xinghe Wang
    Citation: Journal of Translational Medicine 2022 20:223
    Content type: Research Published on:

  16. Acute kidney injury (AKI) is the most common and serious complication of sepsis, accompanied by high mortality and disease burden. The early prediction of AKI is critical for timely intervention and ultimately...

    Authors: Suru Yue, Shasha Li, Xueying Huang, Jie Liu, Xuefei Hou, Yumei Zhao, Dongdong Niu, Yufeng Wang, Wenkai Tan and Jiayuan Wu
    Citation: Journal of Translational Medicine 2022 20:215
    Content type: Research Published on:

  17. Oropharyngeal dysphagia (OD) refers to any abnormality in the physiology of swallowing in the upper gastrointestinal tract, which leads to the related clinical complications, such as malnutrition, dehydration,...

    Authors: Fatemeh Rajati, Nassim Ahmadi, Zahra Al-sadat Naghibzadeh and Mohsen Kazeminia
    Citation: Journal of Translational Medicine 2022 20:175
    Content type: Review Published on:

  19. Acute kidney injury (AKI) is a major complication following cardiac surgery that substantially increases morbidity and mortality. Current diagnostic guidelines based on elevated serum creatinine and/or the pre...

    Authors: Hang Zhang, Zhongtian Wang, Yingdan Tang, Xin Chen, Dongfang You, Yaqian Wu, Min Yu, Wen Chen, Yang Zhao and Xin Chen
    Citation: Journal of Translational Medicine 2022 20:166
    Content type: Research Published on:

  21. Established prediction models of Diabetic kidney disease (DKD) are limited to the analysis of clinical research data or general population data and do not consider hospital visits. Construct a 3-year diabetic ...

    Authors: Zheyi Dong, Qian Wang, Yujing Ke, Weiguang Zhang, Quan Hong, Chao Liu, Xiaomin Liu, Jian Yang, Yue Xi, Jinlong Shi, Li Zhang, Ying Zheng, Qiang Lv, Yong Wang, Jie Wu, Xuefeng Sun…
    Citation: Journal of Translational Medicine 2022 20:143
    Content type: Research Published on:

  23. Determining the risk of Cardiovascular Disease (CVD) is a necessity for timely preventive interventions in high-risk groups. However, laboratory testing may be impractical in countries with limited resources. ...

    Authors: Fatemeh Rezaei, Mozhgan Seif, Abdullah Gandomkar, Mohammad Reza Fattahi, Fatemeh Malekzadeh, Sadaf G. Sepanlou and Jafar Hasanzadeh
    Citation: Journal of Translational Medicine 2022 20:133
    Content type: Research Published on:

  24. Safety, tolerability and efficacy of granulocyte colony-stimulating factor (G-CSF) for mobilization of hematopoietic stem and progenitor cells (HSPCs) from healthy donors have been conclusively demonstrated. T...

    Authors: J. Heyn, S. Bräuninger, M. Dimova-Dobreva, N. Mathieson, N. Koptelova, A. Kolpakova, C. Seidl, P. Reinhardt, C. Tsamadou, H. Schrezenmeier, R. Nakov, E. Seifried and H. Bonig
    Citation: Journal of Translational Medicine 2022 20:121
    Content type: Research Published on:

  25. Frailty, determined by the Canadian Study of Health and Aging-Clinical Frailty Scale (CFS), is strongly associated with clinical outcomes including mortality in patients with COVID-19. However, the relationshi...

    Authors: Josh McGovern, Yassir Al-Azzawi, Olivia Kemp, Peter Moffitt, Conor Richards, Ross D. Dolan, Barry J. Laird, Donald C. McMillan and Donogh Maguire
    Citation: Journal of Translational Medicine 2022 20:98
    Content type: Research Published on:

  26. The number of elderly patients with early renal cell carcinoma (RCC) is on the rise. However, there is still a lack of accurate prediction models for the prognosis of early RCC in elderly patients. It is neces...

    Authors: Jinkui Wang, Jie Tang, Tiaoyao Chen, Song Yue, Wanting Fu, Zulong Xie and Xiaozhu Liu
    Citation: Journal of Translational Medicine 2022 20:90
    Content type: Research Published on:

  27. Epithelial–mesenchymal transition (EMT) is a dynamic and complex cellular process that is known to be hijacked by cancer cells to facilitate invasion, metastasis and therapeutic resistance. Several quantitativ...

    Authors: Ankit P. Jain, Janani Sambath, Gajanan Sathe, Irene A. George, Akhilesh Pandey, Erik W. Thompson and Prashant Kumar
    Citation: Journal of Translational Medicine 2022 20:84
    Content type: Research Published on:

  28. Chinese herbal medicine is made up of hundreds of natural drug molecules and has played a major role in traditional Chinese medicine (TCM) for several thousand years. Therefore, it is of great significance to ...

    Authors: Pengcheng Zhao, Lin Lin, Mozheng Wu, Lili Wang, Qi Geng, Li Li, Ning Zhao, Jianyu Shi and Cheng Lu
    Citation: Journal of Translational Medicine 2022 20:67
    Content type: Research Published on:

  29. Approximately 40% of persons with inflammatory bowel disease (IBD) experience psychiatric comorbidities (PC). Previous studies demonstrated the polygenetic effect on both IBD and PC. In this study, we evaluate...

    Authors: Yao Li, Charles N. Bernstein, Wei Xu and Pingzhao Hu
    Citation: Journal of Translational Medicine 2022 20:43
    Content type: Research Published on:

  30. A fraction of patients referred for complex molecular profiling of biopsied tumors may harbor germline variants in genes associated with the development of hereditary cancer syndromes (HCS). Neither the bioinf...

    Authors: Alexandra Lebedeva, Yulia Shaykhutdinova, Daria Seriak, Ekaterina Ignatova, Ekaterina Rozhavskaya, Divyasphoorthi Vardhan, Sofia Manicka, Margarita Sharova, Tatiana Grigoreva, Ancha Baranova, Vladislav Mileyko and Maxim Ivanov
    Citation: Journal of Translational Medicine 2022 20:29
    Content type: Research Published on:

  31. Sepsis is the leading cause of death in the intensive care unit (ICU). Expediting its diagnosis, largely determined by clinical assessment, improves survival. Predictive and explanatory modelling of sepsis in ...

    Authors: Holger A. Lindner, Shigehiko Schamoni, Thomas Kirschning, Corinna Worm, Bianka Hahn, Franz-Simon Centner, Jochen J. Schoettler, Michael Hagmann, Jörg Krebs, Dennis Mangold, Stephanie Nitsch, Stefan Riezler, Manfred Thiel and Verena Schneider-Lindner
    Citation: Journal of Translational Medicine 2022 20:27
    Content type: Research Published on:

  32. We aimed to compare cardiovascular risks among participants with T2DM with and without subsequent HTN and participants with HTN with and without subsequent T2DM.

    Authors: Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu and Chii-Min Hwu
    Citation: Journal of Translational Medicine 2022 20:9
    Content type: Research Published on:

  33. People with liver disease are at increased risk of developing cardiovascular disease (CVD), however, there has yet been an investigation of incidence burden, risk, and premature mortality across a wide range o...

    Authors: Wai Hoong Chang, Stefanie H. Mueller, Sheng-Chia Chung, Graham R. Foster and Alvina G. Lai
    Citation: Journal of Translational Medicine 2022 20:2
    Content type: Research Published on:

  34. The current guidelines of the American Joint Committee on Cancer (AJCC) for the staging of exocrine pancreatic tumors seem inapplicable to malignant pancreatic intraductal papillary mucinous neoplasms (IPMN). ...

    Authors: Haoxiang Zhang, Chenggang Gao, Jiaoshun Chen, Shihong Wu, Jianwei Bai and Tao Yin
    Citation: Journal of Translational Medicine 2021 19:525
    Content type: Research Published on:

  35. Association between blood pressure (BP) and kidney function among the middle and old aged general population without hypertension remains unclear.

    Authors: Huai-yu Wang, Qinqin Meng, Chao Yang, Yafeng Wang, Guilan Kong, Yaohui Zhao, Fang Wang and Luxia Zhang
    Citation: Journal of Translational Medicine 2021 19:512
    Content type: Research Published on:

  36. Cancer is one of the most serious diseases threatening human health. Cancer immunotherapy represents the most promising treatment strategy due to its high efficacy and selectivity and lower side effects compar...

    Authors: Shihu Jiao, Quan Zou, Huannan Guo and Lei Shi
    Citation: Journal of Translational Medicine 2021 19:449
    Content type: Research Published on:

  37. High morbidity and mortality due to carbapenem-resistant Gram-negative bacilli (CR-GNB) has led to the resurgence of polymyxin B (PMB) use in the last decade. The aim of our multicenter, real-world study was t...

    Authors: Xiaojuan Zhang, Shaoyan Qi, Xiaoguang Duan, Bing Han, Shuguang Zhang, Shaohua Liu, Haixu Wang, Haibo Zhang and Tongwen Sun
    Citation: Journal of Translational Medicine 2021 19:431
    Content type: Research Published on:

  38. The association between exposure to air pollution and sudden sensorineural hearing loss (SSNHL) has not been extensively discussed in the literature. Therefore, we conducted this nationwide study to evaluate t...

    Authors: Stella Chin-Shaw Tsai, Yi-Chao Hsu, Jung-Nien Lai, Ruey-Hwang Chou, Hueng-Chuen Fan, Frank Cheau-Feng Lin, Ruihong Zhang, Cheng-Li Lin and Kuang-Hsi Chang
    Citation: Journal of Translational Medicine 2021 19:424
    Content type: Research Published on:

  39. The Wnt signaling pathway is core to the growth of bladder tumors. Epithelial-to-mesenchymal transition (EMT) is significant for bladder tumor metastasis. Nevertheless, the relationship between the Wnt signali...

    Authors: Siqing Sun, Yutao Wang, Jianfeng Wang and Jianbin Bi
    Citation: Journal of Translational Medicine 2021 19:409
    Content type: Research Published on:

  40. The molecular profiling of glioblastoma (GBM) based on transcriptomic analysis could provide precise treatment and prognosis. However, current subtyping (classic, mesenchymal, neural, proneural) is time-consum...

    Authors: Minjie Fu, Jinsen Zhang, Weifeng Li, Shan He, Jingwen Zhang, Daniel Tennant, Wei Hua and Ying Mao
    Citation: Journal of Translational Medicine 2021 19:404
    Content type: Research Published on:

  41. Sjogren’s syndrome (SS) is a heterogenous disease with various phenotypes. We aimed to provide a relevant subclassification based on symptom-based clustering for patients with primary (p) SS.

    Authors: Jennifer Jooha Lee, Young Jae Park, Misun Park, Hyeon Woo Yim, Sung Hwan Park and Seung-Ki Kwok
    Citation: Journal of Translational Medicine 2021 19:394
    Content type: Research Published on:

  42. COVID-19 remains globally a highly infectious disease targeting multiple organs. Rehabilitation is increasingly valued among the supportive care fields to combat COVID-19 as currently definitive curative treat...

    Authors: Chaoran Yu and Ernest Johann Helwig
    Citation: Journal of Translational Medicine 2021 19:376
    Content type: Review Published on:

  43. The prevalence of chronic pain conditions is growing. Low back pain was the primary cause of disability worldwide out of 156 conditions assessed between 1990 and 2016, according to the Global Burden of Disease...

    Authors: Daniel I. Rhon, Julie M. Fritz, Tina A. Greenlee, Katie E. Dry, Rachel J. Mayhew, Mary C. Laugesen, Edita Dragusin and Deydre S. Teyhen
    Citation: Journal of Translational Medicine 2021 19:357
    Content type: Methodology Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:573

  44. Pancreatic cancer is a fatal malignancy of the digestive system and the 5-year survival rate remains low. Therefore, new molecular therapeutic targets are required to improve treatments, prognosis, and the sur...

    Authors: Juan Zeng, Heying Zhang, Yonggang Tan, Zhe Wang, Yunwei Li and Xianghong Yang
    Citation: Journal of Translational Medicine 2021 19:323
    Content type: Research Published on:

  45. Early prediction of acute kidney injury (AKI) after liver transplantation (LT) facilitates timely recognition and intervention. We aimed to build a risk predictor of post-LT AKI via supervised machine learning...

    Authors: Yihan Zhang, Dong Yang, Zifeng Liu, Chaojin Chen, Mian Ge, Xiang Li, Tongsen Luo, Zhengdong Wu, Chenguang Shi, Bohan Wang, Xiaoshuai Huang, Xiaodong Zhang, Shaoli Zhou and Ziqing Hei
    Citation: Journal of Translational Medicine 2021 19:321
    Content type: Research Published on:

  46. Several predictive factors for chronic kidney disease (CKD) following radical nephrectomy (RN) or partial nephrectomy (PN) have been identified. However, early postoperative laboratory values were infrequently...

    Authors: Dongwoo Chae, Na Young Kim, Ki Jun Kim, Kyemyung Park, Chaerim Oh and So Yeon Kim
    Citation: Journal of Translational Medicine 2021 19:307
    Content type: Research Published on:

  47. Immunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which is one of the important challenges. Detecting the regulation of immune cells and biomarkers concerning immune checkpoint...

    Authors: Jingwen Wang, Feng Li, Yanjun Xu, Xuan Zheng, Chunlong Zhang, Congxue Hu, Yingqi Xu, Wanqi Mi, Xia Li and Yunpeng Zhang
    Citation: Journal of Translational Medicine 2021 19:296
    Content type: Research Published on:

  48. Heart failure (HF) with preserved ejection fraction (HFpEF) is a leading cause of hospitalizations and mortality when diagnosed at the age of ≥ 65 years. HFpEF represents multifactorial and multisystemic syndr...

    Authors: Ying Lin, Shihui Fu, Yao Yao, Yulong Li, Yali Zhao and Leiming Luo
    Citation: Journal of Translational Medicine 2021 19:291
    Content type: Review Published on:

  49. We performed a prospective multicentre diagnostic study to evaluate the combined interferon-γ (IFN-γ) and interleukin-2 (IL-2) release assay for detect active pulmonary tuberculosis (TB) in China.

    Authors: Yaoju Tan, Yunhong Tan, Junlian Li, Pengnan Hu, Ping Guan, Haobin Kuang, Qide Liang, Yanyan Yu, Zhongnan Chen, Quan Wang, Zhenping Yang, DiLiNaZi AiKeReMu, Yu Pang and Jianxiong Liu
    Citation: Journal of Translational Medicine 2021 19:289
    Content type: Research Published on:

  50. This study aimed to establish and validate an easy-to-operate novel scoring system based on simple and readily available clinical indices for predicting the progression of chronic kidney disease (CKD).

    Authors: Qian Xu, Yunyun Wang, Yiqun Fang, Shanshan Feng, Cuiyun Chen and Yanxia Jiang
    Citation: Journal of Translational Medicine 2021 19:288
    Content type: Research Published on:
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