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Cardiovascular, metabolic and Lipoprotein translation

Section edited by Nehal N. Mehta

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

Featured articles

Transforming growth factor-beta 1 produced by vascular smooth muscle cells predicts fibrosis in the gastrocnemius of patients with peripheral artery disease
Duy M. Ha, et al

Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction
Roseanne Raphael, et al

Chronic, not acute, skin-specific inflammation promotes thrombosis in psoriasis murine models.
Jackelyn B. Golden, et al

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  1. Cardiac gene therapy for heart disease is a major translational research area with potential, yet problems with safe and efficient gene transfer into cardiac muscle remain unresolved. Existing methodology to i...

    Authors: Anthony S Fargnoli, Anbin Mu, Michael G Katz, Richard D Williams, Kenneth B Margulies, David B Weiner, Shu Yang and Charles R Bridges

    Citation: Journal of Translational Medicine 2014 12:171

    Content type: Methodology

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  2. Consecutive treatment of normal heart with a high dose of isoproterenol and adenosine (Iso/Ade treatment), confers strong protection against ischaemia/reperfusion injury. In preparation for translation of this...

    Authors: Igor Khaliulin, Andrew P Halestrap, Simon M Bryant, Declan J Dudley, Andrew F James and M-Saadeh Suleiman

    Citation: Journal of Translational Medicine 2014 12:139

    Content type: Research

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  3. Despite recent advances, myocardial infarction (MI) remains the leading cause of death worldwide. Pre-clinical animal models that closely mimic human MI are pivotal for a quick translation of research and swin...

    Authors: Carolina Gálvez-Montón, Cristina Prat-Vidal, Idoia Díaz-Güemes, Verónica Crisóstomo, Carolina Soler-Botija, Santiago Roura, Aida Llucià-Valldeperas, Isaac Perea-Gil, Francisco M Sánchez-Margallo and Antoni Bayes-Genis

    Citation: Journal of Translational Medicine 2014 12:137

    Content type: Research

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  4. The addition of an intra-aortic balloon pump (IABP) during peripheral venoarterial extracorporeal membrane oxygenation (VA ECMO) support has been shown to improve coronary bypass graft flows and cardiac functi...

    Authors: Feng Yang, Zai-shen Jia, Jia-lin Xing, Zheng Wang, Yuan Liu, Xing Hao, Chun-jing Jiang, Hong Wang, Ming Jia and Xiao-tong Hou

    Citation: Journal of Translational Medicine 2014 12:106

    Content type: Research

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  5. Berberine (BBR), a natural plant extract, has been shown to improve lipid metabolism. However, its effects on PCSK9, a key factor involving in the lipid metabolism, have not yet been evaluated in vivo. The aim...

    Authors: Yan-Jun Jia, Rui-Xa Xu, Jing Sun, Yue Tang and Jian-Jun Li

    Citation: Journal of Translational Medicine 2014 12:103

    Content type: Research

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  6. We tested the hypothesis that clopidogrel and cilostazol combination therapy could effectively attenuate systemic inflammatory reaction, facilitate proliferation of circulating endothelial progenitor cell (EPC...

    Authors: Jiunn-Jye Sheu, Pao-Yuan Lin, Pei-Hsun Sung, Yi-Ching Chen, Steve Leu, Yung-Lung Chen, Tzu-Hsien Tsai, Han-Tan Chai, Sarah Chua, Hsueh-Wen Chang, Sheng-Ying Chung, Chih-Hung Chen, Sheung-Fat Ko and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2014 12:101

    Content type: Research

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  7. Transient episodes of ischemia in a remote organ or tissue (remote ischemic preconditioning, RIPC) can attenuate myocardial injury. Myocardial damage is associated with tissue remodeling and the matrix metallo...

    Authors: Karina Zitta, Patrick Meybohm, Berthold Bein, Matthias Gruenewald, Fabian Lauer, Markus Steinfath, Jochen Cremer, Kai Zacharowski and Martin Albrecht

    Citation: Journal of Translational Medicine 2014 12:94

    Content type: Research

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  8. The atrial fibrillation (AF) associated microRNAs (miRNAs) were found in the right atrium (RA) and left atrium (LA) from patients with rheumatic mitral valve disease (RMVD). However, most studies only focus on...

    Authors: Hai Liu, Han Qin, Guang-xian Chen, Meng-ya Liang, Jian Rong, Jian-ping Yao and Zhong-kai Wu

    Citation: Journal of Translational Medicine 2014 12:90

    Content type: Research

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  9. Up-regulation of HO-1 by genetic manipulation or pharmacological pre-treatment has been reported to provide benefits in several animal models of myocardial infarction (MI). However, its efficacy following MI i...

    Authors: Claudia Kusmic, Cristina Barsanti, Marco Matteucci, Nicoletta Vesentini, Gualtiero Pelosi, Nader G Abraham and Antonio L’Abbate

    Citation: Journal of Translational Medicine 2014 12:89

    Content type: Research

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  10. In kidney transplantation, the prevalence of hypercholesterolemia as a co-morbidity factor known to affect graft function, is rising due to the increased number of older donors in response to organ shortage as...

    Authors: Nicolas Chatauret, Frédéric Favreau, Sebastien Giraud, Antoine Thierry, Ludivine Rossard, Sylvain Le Pape, Lilach O Lerman and Thierry Hauet

    Citation: Journal of Translational Medicine 2014 12:76

    Content type: Research

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  11. Restoration of the mechanical and endocrine functions of the left atrium remains controversial after electrical cardioversion treatment for persistent atrial fibrillation. The objective of the prospective stud...

    Authors: Anne Bernard-Brunet, Christophe Saint Etienne, Eric Piver, Noura Zannad, Jean-Christophe Pagés, Laurent Fauchier and Dominique Babuty

    Citation: Journal of Translational Medicine 2014 12:51

    Content type: Research

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  12. Although reperfusion injury has been shown to be responsible for cardiomyocytes death after an acute myocardial infarction, there is currently no drug on the market that reduces this type of injury. TRO40303 i...

    Authors: Sophie Le Lamer, Stéphanie Paradis, Hidayat Rahmouni, Corinne Chaimbault, Magali Michaud, Marcel Culcasi, Jean Afxantidis, Mathilde Latreille, Patrick Berna, Alain Berdeaux, Sylvia Pietri, Didier Morin, Yves Donazzolo, Jean-Louis Abitbol, Rebacca M Pruss and Sophie Schaller

    Citation: Journal of Translational Medicine 2014 12:38

    Content type: Research

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  13. We aim to develop a rat model of veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

    Authors: Ayyaz A Ali, Peter Downey, Gopal Singh, Wei Qi, Isaac George, Hiroo Takayama, Ajay Kirtane, Prakash Krishnan, Adrian Zalewski, Darren Freed, Stephen R Large, Euan A Ashley, Martin B Leon, Matthew Bacchetta and Ziad A Ali

    Citation: Journal of Translational Medicine 2014 12:37

    Content type: Methodology

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  14. Oxidative stress and DNA damage have been implicated in the pathogenesis of renovascular hypertension induced by renal artery stenosis in the two-kidney, one-clip (2K1C) Goldblatt model. Considering our previo...

    Authors: Ananda T Dias, Bianca P Rodrigues, Marcella L Porto, Agata L Gava, Camille M Balarini, Flavia P S Freitas, Zaira Palomino, Dulce E Casarini, Bianca P Campagnaro, Thiago M C Pereira, Silvana S Meyrelles and Elisardo C Vasquez

    Citation: Journal of Translational Medicine 2014 12:35

    Content type: Research

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  17. Selenoprotein S (SelS) is an important endoplasmic reticulum and plasma membrane-located selenoprotein implicated in inflammatory responses and insulin resistance. However, the effects of SelS on endothelial c...

    Authors: Yin Zhao, Hua Li, Li-li Men, Rong-chong Huang, Hai-cheng Zhou, Qian Xing, Jun-jie Yao, Chun-hong Shi and Jian-ling Du

    Citation: Journal of Translational Medicine 2013 11:287

    Content type: Research

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  18. Insulin resistance (IR) is frequently associated with endothelial dysfunction and has been proposed to play a major role in cardiovascular disease (CVD). On the other hand, obesity has long been related to IR ...

    Authors: Mariam El Assar, Juan Carlos Ruiz de Adana, Javier Angulo, María Luz Pindado Martínez, Alberto Hernández Matías and Leocadio Rodríguez-Mañas

    Citation: Journal of Translational Medicine 2013 11:263

    Content type: Research

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  19. Notch signaling is known to be activated following myocardial ischemia, but its role in cardioprotection provided by ischemic preconditioning (IPC) and ischemic postconditioning (IPost) remains unclear.

    Authors: Xue-liang Zhou, Li Wan, Qi-rong Xu, Yong Zhao and Ji-chun Liu

    Citation: Journal of Translational Medicine 2013 11:251

    Content type: Research

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  20. Angiotensin-converting enzyme 2 (ACE2), a monocarboxypeptidase which metabolizes angiotensin II (Ang II) to generate Ang-(1–7), has been shown to prevent cardiac hypertrophy and injury but the mechanism remain...

    Authors: Zhen-Zhou Zhang, Qian-Hui Shang, Hai-Yan Jin, Bei Song, Gavin Y Oudit, Lin Lu, Tong Zhou, Ying-Le Xu, Ping-Jin Gao, Ding-Liang Zhu, Josef M Penninger and Jiu-Chang Zhong

    Citation: Journal of Translational Medicine 2013 11:229

    Content type: Research

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  21. The presence of endothelial dysfunction (ED) constitutes an early risk factor for cardiovascular disease (CVD) in children. Nitric oxide (NO) and endothelin (EDN) are generated in endothelial cells and are cri...

    Authors: Siriporn Chatsuriyawong, David Gozal, Leila Kheirandish-Gozal, Rakesh Bhattacharjee, Ahamed A Khalyfa, Yang Wang, Hakon Hakonarson, Brendan Keating, Wasana Sukhumsirichart and Abdelnaby Khalyfa

    Citation: Journal of Translational Medicine 2013 11:227

    Content type: Research

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  22. Clinical studies have shown that radiotherapy increases the risk of cardiovascular disease at irradiated sites years after exposure. However, there is a lack of biological explanations in humans. We therefore ...

    Authors: Tinna Christersdottir Björklund, Sarah-Jayne Reilly, Caroline Gahm, Barbara Bottazzi, Alberto Mantovani, Per Tornvall and Martin Halle

    Citation: Journal of Translational Medicine 2013 11:223

    Content type: Research

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  23. Previous study demonstrated that miR-133a was released into blood from injured myocardium in cardiovascular diseases. However, the dynamic change of circulating miR-133a level in the early phase of acute myoca...

    Authors: Feng Wang, Guangwen Long, Chunxia Zhao, Huaping Li, Sandip Chaugai, Yan Wang, Chen Chen and Dao Wen Wang

    Citation: Journal of Translational Medicine 2013 11:222

    Content type: Research

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  24. M3 muscarinic acetylcholine receptor (M3-mAChR) is stably expressed in the myocardium, but its pathophysiological role remains largely undefined. This study aimed to investigate the role of M3-mAChR in cardiac hy...

    Authors: Yan Liu, Shu Wang, Chao Wang, Haoxin Song, Hongmei Han, Pengzhou Hang, Yanan Jiang, Lanlan Wei, Rong Huo, Lihua Sun, Xu Gao, Yanjie Lu and Zhimin Du

    Citation: Journal of Translational Medicine 2013 11:209

    Content type: Research

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  25. Vascular smooth muscle cells (SMC) are central to arterial structure and function yet their involvement in the progression of abdominal aortic aneurysm (AAA) disease is not well studied. The progressive and si...

    Authors: Kirsten Riches, Timothy G Angelini, Gurprit S Mudhar, Jean Kaye, Emily Clark, Marc A Bailey, Soroush Sohrabi, Sotirios Korossis, Peter G Walker, D Julian A Scott and Karen E Porter

    Citation: Journal of Translational Medicine 2013 11:208

    Content type: Research

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  27. Wall stress is a useful concept to understand the progression of ventricular remodeling. We measured cumulative LV wall stress throughout the cardiac cycle over unit time and tested whether this “integrated wa...

    Authors: Hailong Dong, Heather Mosca, Erhe Gao, Robert E Akins, Samuel S Gidding and Takeshi Tsuda

    Citation: Journal of Translational Medicine 2013 11:183

    Content type: Research

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  28. The adipokine leptin and its receptor are expressed in the heart, and leptin has been shown to promote cardiomyocyte hypertrophy in vitro. Obesity is associated with hyperleptinemia and hypothalamic leptin resist...

    Authors: Maren Leifheit-Nestler, Nana-Maria Wagner, Rajinikanth Gogiraju, Michael Didié, Stavros Konstantinides, Gerd Hasenfuss and Katrin Schäfer

    Citation: Journal of Translational Medicine 2013 11:170

    Content type: Research

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  29. There is a significant clinical overlap between patients with hepatocyte nuclear factor (HNF)-1A and HNF4A maturity-onset diabetes of the young (MODY), two forms of monogenic diabetes. HNF1A and HNF4A are tran...

    Authors: Ma P Kyithar, Caroline Bonner, Siobhan Bacon, Seán M Kilbride, Jasmin Schmid, Rolf Graf, Jochen HM Prehn and Maria M Byrne

    Citation: Journal of Translational Medicine 2013 11:156

    Content type: Research

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  30. MicroRNAs were enrolled in various cardiovascular disease especially ischemic heart diseases, but the microRNA changes during myocardial ischemia reperfusion injury underwent cardiopulmonary bypass are still u...

    Authors: Han Qin, Guang-xian Chen, Meng-ya Liang, Jian Rong, Jian-ping Yao, Hai Liu and Zhong-kai Wu

    Citation: Journal of Translational Medicine 2013 11:154

    Content type: Research

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  31. The present study aimed at using a proteomics based approach to: a) analyze and contrast the proteome of the healthy and isoproterenol induced hypertrophied hearts and b) identify potential biomarkers for diag...

    Authors: Debabrata Chowdhury, Anjana Devi Tangutur, Tarak Nath Khatua, Priyanka Saxena, Sanjay K Banerjee and Manika Pal Bhadra

    Citation: Journal of Translational Medicine 2013 11:130

    Content type: Research

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  32. Mild therapeutic hypothermia (HT) has been implemented in the management of post cardiac arrest (CA) syndrome after the publication of clinical trials comparing HT with common practice (ie, usually hyperthermi...

    Authors: Petr Ostadal, Mikulas Mlcek, Andreas Kruger, Svatava Horakova, Marcela Skabradova, Frantisek Holy, Tomas Svoboda, Jan Belohlavek, Vladimir Hrachovina, Ludek Taborsky, Vlasta Dudkova, Hana Psotova, Otomar Kittnar and Petr Neuzil

    Citation: Journal of Translational Medicine 2013 11:124

    Content type: Research

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  33. Whilst advances in reperfusion therapies have reduced early mortality from acute myocardial infarction, heart failure remains a common complication, and may develop very early or long after the acute event. Re...

    Authors: Nishat Siddiqi, Margaret Bruce, Christopher J Neil, Baljit Jagpal, Graeme Maclennon, Seonaidh C Cotton, Sofia A Papadopoulo, Nicholas Bunce, Pitt Lim, Konstantin Schwarz, Satnam Singh, David Hildick-Smith, John D Horowitz, Melanie Madhani, Nicholas Boon, Juan-Carlos Kaski…

    Citation: Journal of Translational Medicine 2013 11:116

    Content type: Protocol

    Published on:

  34. Catalase (CAT) breaks down H2O2 into H2O and O2 to protects cells from oxidative damage. However, its translational potential is limited because exogenous CAT cannot enter living cells automatically. This study i...

    Authors: Lei Zhang, Shuang Wei, Jun-Ming Tang, Ling-Yun Guo, Fei Zheng, Jian-Ye Yang, Xia Kong, Yong-Zhang Huang, Shi-You Chen and Jia-Ning Wang

    Citation: Journal of Translational Medicine 2013 11:113

    Content type: Research

    Published on:

  35. Endothelium-dependent flow mediated dilation (FMD) and pulse-wave velocity (PWV), are used as measures of vascular health and predictors of cardiovascular risk in clinical studies, and both are age-dependent. ...

    Authors: Delvin R Knight Jr, Andrew H Smith, Richard L Schroeder, Chunli Huang, David A Beebe, Sharon A Sokolowski and Miao Wang

    Citation: Journal of Translational Medicine 2013 11:101

    Content type: Research

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  36. Serum thiols have shown associations with surrogate markers of cardiovascular disease. However, little information is available on their combined association with validated cardiovascular risk scores for prima...

    Authors: Arduino A Mangoni, Angelo Zinellu, Ciriaco Carru, John R Attia and Marc McEvoy

    Citation: Journal of Translational Medicine 2013 11:99

    Content type: Research

    Published on:

  37. Sevoflurane is an anesthetic agent which also participates in protective mechanisms in sepsis, likely due to anti-inflammatory properties. A key tissue in sepsis is the endothelium, which expresses TLR2 and TL...

    Authors: Raquel Rodríguez-González, Aurora Baluja, Sonia Veiras Del Río, Alfonso Rodríguez, Jaime Rodríguez, Manuel Taboada, David Brea and Julián Álvarez

    Citation: Journal of Translational Medicine 2013 11:87

    Content type: Research

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  38. Lixisenatide is a glucagon-like peptide-1 analog which stimulates insulin secretion and inhibits glucagon secretion and gastric emptying. We investigated cardioprotective effects of lixisenatide in rodent mode...

    Authors: Paulus Wohlfart, Wolfgang Linz, Thomas Hübschle, Dominik Linz, Jochen Huber, Sibylle Hess, Daniel Crowther, Ulrich Werner and Hartmut Ruetten

    Citation: Journal of Translational Medicine 2013 11:84

    Content type: Research

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  39. Ritonavir is a HIV protease inhibitor. In addition to its antiviral effect, Ritonavir directly inhibits the insulin-regulated glucose transporter GLUT4 and blocks glucose entry into fat and muscle cells. Howev...

    Authors: Prachi Gupta, Abhinav Kanwal, Uday Kumar Putcha, Yogesh Bulani, Bhavesh Sojitra, Tarak Nath Khatua, Madhusudana Kuncha and Sanjay Kumar Banerjee

    Citation: Journal of Translational Medicine 2013 11:80

    Content type: Research

    Published on:

  40. Race- and gender-variation in innate immunity may contribute to demographic differences in inflammatory and cardiometabolic disease; yet their influence on dynamic responses during inflammatory stress is poorl...

    Authors: Jane F Ferguson, Parth N Patel, Rhia Y Shah, Claire K Mulvey, Ram Gadi, Prabhjot S Nijjar, Haris M Usman, Nehal N Mehta, Rachana Shah, Stephen R Master, Kathleen J Propert and Muredach P Reilly

    Citation: Journal of Translational Medicine 2013 11:63

    Content type: Research

    Published on:

  41. This pilot study investigated the association between heat shock protein 70 (HSP70) and anti-HSP70 antibodies as well as their changes and rhythm outcome after atrial fibrillation (AF) catheter ablation.

    Authors: Jelena Kornej, Claudia Reinhardt, Jedrzej Kosiuk, Arash Arya, Gerhard Hindricks, Volker Adams, Daniela Husser and Andreas Bollmann

    Citation: Journal of Translational Medicine 2013 11:49

    Content type: Research

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  42. Left ventricular (LV) remodeling following large transmural myocardial infarction (MI) remains a pivotal clinical issue despite the advance of medical treatment over the past few decades. Identification of new...

    Authors: Yue-Feng Chen, Nathan Y Weltman, Xiang Li, Steven Youmans, David Krause and Anthony Martin Gerdes

    Citation: Journal of Translational Medicine 2013 11:40

    Content type: Research

    Published on:

  43. Recently, the high-mobility group A1 gene (HMGA1) variant IVS5-13insC has been associated with type 2 diabetes, but reported associations are inconsistent and data are lacking in Hispanic and African American pop...

    Authors: Jason H Karnes, Taimour Y Langaee, Caitrin W McDonough, Shin-Wen Chang, Miguel Ramos, James R Catlin Jr, Octavio E Casanova, Yan Gong, Carl J Pepine, Julie A Johnson and Rhonda M Cooper-DeHoff

    Citation: Journal of Translational Medicine 2013 11:12

    Content type: Research

    Published on:

  44. Increasing evidences have suggested that autoantibodies against muscarinic-2 acetylcholine receptor (anti-M2-R) may play an important role in the development of atrial fibrillation (AF). Predictive value of pre-p...

    Authors: Changhong Zou, Zhiyong Zhang, Wenmin Zhao, Guang Li, Guiling Ma, Xinchun Yang, Jianjun Zhang and Lin Zhang

    Citation: Journal of Translational Medicine 2013 11:7

    Content type: Research

    Published on:

  45. Atherosclerosis is an inflammatory process of the arterial walls and is initiated by endothelial dysfunction accompanied by an imbalance in the production of reactive oxygen species (ROS) and nitric oxide (NO)...

    Authors: Camille M Balarini, Marcos A Leal, Isabele B S Gomes, Thiago M C Pereira, Agata L Gava, Silvana S Meyrelles and Elisardo C Vasquez

    Citation: Journal of Translational Medicine 2013 11:3

    Content type: Research

    Published on:

  47. The additive effects of obesity and metabolic syndrome on left ventricular (LV) maladaptive remodeling and function in hypertension are not characterized.

    Authors: Dominik Linz, Mathias Hohl, Felix Mahfoud, Jan-Christian Reil, Wolfgang Linz, Thomas Hübschle, Hans-Paul Juretschke, Claudia Neumann-Häflin, Hartmut Rütten and Michael Böhm

    Citation: Journal of Translational Medicine 2012 10:187

    Content type: Research

    Published on:

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Journal of Translational Medicine

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