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Cardiovascular, Metabolic and Lipoprotein Translation

Section edited by Nehal N. Mehta and Tommaso Angelone
© Juan Gärtner/ stock.adob

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

Featured articles


Immune cell phenotyping in low blood volumes for assessment of cardiovascular disease risk, development, and progression: a pilot study

Research | Yvonne Baumer et al


Comprehensive analysis of differential immunocyte infiltration and the potential ceRNA networks during epicardial adipose tissue development in congenital heart disease

Research | Li Ma et al


Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration​​​​​​​

Research | Sharon F Wu et al

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  1. We investigated whether attenuating dipeptidyl peptidase-IV (DPP4) enzyme activity protected rat heart from ischemia-reperfusion (IR) injury (40-min left anterior descending coronary artery ligation followed by 7...

    Authors: Sarah Chua, Fan-Yen Lee, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Steve Leu, Cheuk-Kwan Sun, Yung-Lung Chen, Hsueh-Wen Chang, Han-Tan Chai, Chu-Feng Liu, Hung-I Lu and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2014 12:357
  2. Aldosterone synthase inhibition provides the potential to attenuate both the mineralocorticoid receptor-dependent and independent actions of aldosterone. In vitro studies with recombinant human enzymes showed LCI...

    Authors: Joël Ménard, Dean F Rigel, Catherine Watson, Arco Y Jeng, Fumin Fu, Michael Beil, Jing Liu, Wei Chen, Chii-Whei Hu, Jennifer Leung-Chu, Daniel LaSala, Guiqing Liang, Sam Rebello, Yiming Zhang and William P Dole
    Citation: Journal of Translational Medicine 2014 12:340
  3. Glycated hemoglobin A1c (HbA1c) has been used as an index of glycemic control in the management, guidance, and clinical trials of diabetic patients for the past 35 years. The aim of this study was to validate the...

    Authors: Piotr Ladyzynski, Piotr Foltynski, Marianna I Bak, Stanislawa Sabalinska, Janusz Krzymien and Jerzy Kawiak
    Citation: Journal of Translational Medicine 2014 12:328
  4. Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to the various effects of steroids on multi-system pathways involved into osteoblast differentiation, oste...

    Authors: Yini Jiang, Yanqiong Zhang, Weiheng Chen, Chunfang Liu, Xiaomin Li, Danni Sun, Zhenli Liu, Ying Xu, Xia Mao, Qiuyan Guo and Na Lin
    Citation: Journal of Translational Medicine 2014 12:334

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:208

  5. Acute, high-dose folic acid (FA) administration has recently been shown to possess unprecedented effective cardioprotection against ischaemia/reperfusion (I/R) injury. Here we explore the translation potential...

    Authors: Coert J Zuurbier, Andre Heinen, Anneke Koeman, Roy Stuifbergen, Theodorus BM Hakvoort, Nina C Weber and Markus W Hollmann
    Citation: Journal of Translational Medicine 2014 12:325
  6. Our previous in vitro and clinical work has demonstrated anti-inflammatory effects of berberine (BBR), but the clinical application of BBR is limited by its poor bioavailability. Derivatives of BBR have been sugg...

    Authors: Junwen Chen, Jiatian Cao, Lu Fang, Bo Liu, Qing Zhou, Yinggang Sun, Yue Wang, Yigang Li and Shu Meng
    Citation: Journal of Translational Medicine 2014 12:326
  7. Hordeum vulgare L. (HV or barley) is used by traditional healers to treat various inflammatory and cardiovascular diseases, without the knowledge of pharmacologic rationale behind its actions. This study was des...

    Authors: Saima Gul, Sagheer Ahmed, Nurolaini Kifli, Qazi Tahir Uddin, Nafisa Batool Tahir, Abrar Hussain, Hawa ZE Jaafar, Marius Moga and Muhammad Zia-Ul-Haq
    Citation: Journal of Translational Medicine 2014 12:316
  8. Patients with pulmonary arterial hypertension (PAH) are treated with vasodilators, including endothelin receptor antagonists (ERAs), phosphodiesterase-5 (PDE-5) inhibitors, soluble guanylyl cyclase activators,...

    Authors: Maria A Cavasin, Kimberly M Demos-Davies, Katherine B Schuetze, Weston W Blakeslee, Matthew S Stratton, Rubin M Tuder and Timothy A McKinsey
    Citation: Journal of Translational Medicine 2014 12:314
  9. Nonalcoholic steatohepatitis (NASH), the advanced stage of nonalcoholic fatty liver disease that is characterized by both steatosis and severe injury in liver, still lacks efficient treatment. The traditional ...

    Authors: Yang Liu, Haiyan Song, Lei Wang, Hanchen Xu, Xiangbing Shu, Li Zhang, Ying Li, Dongfei Li and Guang Ji
    Citation: Journal of Translational Medicine 2014 12:315
  10. Autonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to the progression of heart failure (HF). We hypothesized that chronic vagus nerve stimulation (VNS) could preve...

    Authors: Haiwen Yu, Min Tang, Jun Yu, Xiaohong Zhou, Lepeng Zeng and Shu Zhang
    Citation: Journal of Translational Medicine 2014 12:302
  11. Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic disease, inc...

    Authors: Xin-chen Xu, Hui Chen, Xi Zhang, Zan-jing Zhai, Xu-qiang Liu, An Qin and Er-yi Lu
    Citation: Journal of Translational Medicine 2014 12:284
  12. In coronary arteries, plaque disruption, the major acute clinical manifestations of atherosclerosis, leads to a subsequent cardiac event, such as acute myocardial infarction (AMI) and unstable angina pectoris ...

    Authors: Jiatian Cao, Zhihua Han, Lei Tian, Kan Chen, Yuqi Fan, Bozhi Ye, Weijian Huang, Changqian Wang and Zhouqing Huang
    Citation: Journal of Translational Medicine 2014 12:266
  13. Adipose tissue normally contains immune cells that regulate adipocyte function and contribute to metabolic disorders including obesity and diabetes mellitus. Psoriasis is associated with increased risk for met...

    Authors: Shawn Rose, Elena Stansky, Pradeep K Dagur, Leigh Samsel, Elizabeth Weiner, Amir Jahanshad, Julia Doveikis, Haley B Naik, Martin P Playford, J Philip McCoy and Nehal N Mehta
    Citation: Journal of Translational Medicine 2014 12:258
  14. The clipping of an artery supplying one of the two kidneys (2K1C) activates the renin-angiotensin (Ang) system (RAS), resulting in hypertension and endothelial dysfunction. Recently, we demonstrated the intrar...

    Authors: Ananda T Dias, Amanda S Cintra, Jéssica C Frossard, Zaira Palomino, Dulce E Casarini, Isabele BS Gomes, Camille M Balarini, Agata L Gava, Bianca P Campagnaro, Thiago MC Pereira, Silvana S Meyrelles and Elisardo C Vasquez
    Citation: Journal of Translational Medicine 2014 12:250
  15. Postural tachycardia syndrome (POTS) is a heterogeneous disorder that creates challenges for treatment. Beta-blocker was one of the most commonly used drugs, but it is inconsistently effective. The purpose of ...

    Authors: Qingyou Zhang, Xia Chen, Jiawei Li and Junbao Du
    Citation: Journal of Translational Medicine 2014 12:249
  16. Salvia-Nelumbinis naturalis (SNN), initially called Jiangzhi Granula as a formulae of Chinese medicinal decoction, has been used clinically to treat non-alcoholic fatty liver disease (NAFLD) and related syndro...

    Authors: Li Zhang, Jiaoya Xu, Haiyan Song, Zemin Yao and Guang Ji
    Citation: Journal of Translational Medicine 2014 12:236
  17. Peroxisome proliferator-activated receptor gamma-2 gene (PPARγ2) rs1801282 (Pro12Ala) polymorphism has been associated with lower risk of metabolic disturbance and atherosclerosis. The aim of this study was to an...

    Authors: Pilar García-Broncano, Juan Berenguer, Amanda Fernández-Rodríguez, Daniel Pineda-Tenor, María Ángeles Jiménez-Sousa, Mónica García–Alvarez, Pilar Miralles, Teresa Aldámiz-Echevarria, Juan Carlos López, Dariela Micheloud and Salvador Resino
    Citation: Journal of Translational Medicine 2014 12:235
  18. Remote ischemic preconditioning (RIPC) protects the heart from ischemia and reperfusion (I/R) injury. The underlying molecular mechanisms are unclear. It has been demonstrated that Connexin 43 (Cx43) is critic...

    Authors: Timo Brandenburger, Ragnar Huhn, Andreas Galas, Benedikt H Pannen, Verena Keitel, Franziska Barthel, Inge Bauer and André Heinen
    Citation: Journal of Translational Medicine 2014 12:228
  19. Relative hypovolemia is frequently found in early stages of severe sepsis and septic shock and prompt and aggressive fluid therapy has become standard of care improving tissue perfusion and patient outcome. Th...

    Authors: Nivaldo Ribeiro Villela, Ana Olimpia Maia Teixeira dos Santos, Marcos Lopes de Miranda and Eliete Bouskela
    Citation: Journal of Translational Medicine 2014 12:232
  20. Atherosclerosis is a chronic inflammatory process of the vessel walls, and CD4+ T-cells are peculiar to both human and murine atherosclerotic lesions. There is a recent line of research favoring hypothetic allerg...

    Authors: Giovanni Tarantino, Susan Costantini, Carmine Finelli, Francesca Capone, Eliana Guerriero, Nicolina La Sala, Saverio Gioia and Giuseppe Castello
    Citation: Journal of Translational Medicine 2014 12:214
  21. BAG3 gene mutations have been recently implicated as a novel cause of dilated cardiomyopathy (DCM). Our aim was to evaluate the prevalence of BAG3 mutations in Polish patients with DCM and to search for genotype...

    Authors: Maria Franaszczyk, Zofia T Bilinska, Małgorzata Sobieszczańska-Małek, Ewa Michalak, Justyna Sleszycka, Agnieszka Sioma, Łukasz A Małek, Dorota Kaczmarska, Ewa Walczak, Paweł Włodarski, Łukasz Hutnik, Blanka Milanowska, Zofia Dzielinska, Grzegorz Religa, Jacek Grzybowski, Tomasz Zieliński…
    Citation: Journal of Translational Medicine 2014 12:192
  22. Experimental and human studies have demonstrated that innate immune mechanisms and consequent inflammatory reaction play a critical role in cardiac response to ischemic injury. Thus, the detection of immuno-in...

    Authors: Emanuela Turillazzi, Marco Di Paolo, Margherita Neri, Irene Riezzo and Vittorio Fineschi
    Citation: Journal of Translational Medicine 2014 12:188
  23. Cardiac gene therapy for heart disease is a major translational research area with potential, yet problems with safe and efficient gene transfer into cardiac muscle remain unresolved. Existing methodology to i...

    Authors: Anthony S Fargnoli, Anbin Mu, Michael G Katz, Richard D Williams, Kenneth B Margulies, David B Weiner, Shu Yang and Charles R Bridges
    Citation: Journal of Translational Medicine 2014 12:171
  24. Circulating endothelial progenitor cells (EPCs) may be a biomarker for vascular function and cardiovascular risk in patients with coronary artery disease (CAD). Dimethylarginine dimethylaminohydrolase 2 (DDAH2...

    Authors: Pan-Pan Niu, Yu Cao, Ting Gong, Jin-Hui Guo, Bi-Kui Zhang and Su-Jie Jia
    Citation: Journal of Translational Medicine 2014 12:170
  25. Consecutive treatment of normal heart with a high dose of isoproterenol and adenosine (Iso/Ade treatment), confers strong protection against ischaemia/reperfusion injury. In preparation for translation of this...

    Authors: Igor Khaliulin, Andrew P Halestrap, Simon M Bryant, Declan J Dudley, Andrew F James and M-Saadeh Suleiman
    Citation: Journal of Translational Medicine 2014 12:139
  26. Despite recent advances, myocardial infarction (MI) remains the leading cause of death worldwide. Pre-clinical animal models that closely mimic human MI are pivotal for a quick translation of research and swin...

    Authors: Carolina Gálvez-Montón, Cristina Prat-Vidal, Idoia Díaz-Güemes, Verónica Crisóstomo, Carolina Soler-Botija, Santiago Roura, Aida Llucià-Valldeperas, Isaac Perea-Gil, Francisco M Sánchez-Margallo and Antoni Bayes-Genis
    Citation: Journal of Translational Medicine 2014 12:137
  27. The addition of an intra-aortic balloon pump (IABP) during peripheral venoarterial extracorporeal membrane oxygenation (VA ECMO) support has been shown to improve coronary bypass graft flows and cardiac functi...

    Authors: Feng Yang, Zai-shen Jia, Jia-lin Xing, Zheng Wang, Yuan Liu, Xing Hao, Chun-jing Jiang, Hong Wang, Ming Jia and Xiao-tong Hou
    Citation: Journal of Translational Medicine 2014 12:106
  28. Berberine (BBR), a natural plant extract, has been shown to improve lipid metabolism. However, its effects on PCSK9, a key factor involving in the lipid metabolism, have not yet been evaluated in vivo. The aim...

    Authors: Yan-Jun Jia, Rui-Xa Xu, Jing Sun, Yue Tang and Jian-Jun Li
    Citation: Journal of Translational Medicine 2014 12:103
  29. We tested the hypothesis that clopidogrel and cilostazol combination therapy could effectively attenuate systemic inflammatory reaction, facilitate proliferation of circulating endothelial progenitor cell (EPC...

    Authors: Jiunn-Jye Sheu, Pao-Yuan Lin, Pei-Hsun Sung, Yi-Ching Chen, Steve Leu, Yung-Lung Chen, Tzu-Hsien Tsai, Han-Tan Chai, Sarah Chua, Hsueh-Wen Chang, Sheng-Ying Chung, Chih-Hung Chen, Sheung-Fat Ko and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2014 12:101
  30. Transient episodes of ischemia in a remote organ or tissue (remote ischemic preconditioning, RIPC) can attenuate myocardial injury. Myocardial damage is associated with tissue remodeling and the matrix metallo...

    Authors: Karina Zitta, Patrick Meybohm, Berthold Bein, Matthias Gruenewald, Fabian Lauer, Markus Steinfath, Jochen Cremer, Kai Zacharowski and Martin Albrecht
    Citation: Journal of Translational Medicine 2014 12:94
  31. The atrial fibrillation (AF) associated microRNAs (miRNAs) were found in the right atrium (RA) and left atrium (LA) from patients with rheumatic mitral valve disease (RMVD). However, most studies only focus on...

    Authors: Hai Liu, Han Qin, Guang-xian Chen, Meng-ya Liang, Jian Rong, Jian-ping Yao and Zhong-kai Wu
    Citation: Journal of Translational Medicine 2014 12:90
  32. Up-regulation of HO-1 by genetic manipulation or pharmacological pre-treatment has been reported to provide benefits in several animal models of myocardial infarction (MI). However, its efficacy following MI i...

    Authors: Claudia Kusmic, Cristina Barsanti, Marco Matteucci, Nicoletta Vesentini, Gualtiero Pelosi, Nader G Abraham and Antonio L’Abbate
    Citation: Journal of Translational Medicine 2014 12:89
  33. In kidney transplantation, the prevalence of hypercholesterolemia as a co-morbidity factor known to affect graft function, is rising due to the increased number of older donors in response to organ shortage as...

    Authors: Nicolas Chatauret, Frédéric Favreau, Sebastien Giraud, Antoine Thierry, Ludivine Rossard, Sylvain Le Pape, Lilach O Lerman and Thierry Hauet
    Citation: Journal of Translational Medicine 2014 12:76
  34. Restoration of the mechanical and endocrine functions of the left atrium remains controversial after electrical cardioversion treatment for persistent atrial fibrillation. The objective of the prospective stud...

    Authors: Anne Bernard-Brunet, Christophe Saint Etienne, Eric Piver, Noura Zannad, Jean-Christophe Pagés, Laurent Fauchier and Dominique Babuty
    Citation: Journal of Translational Medicine 2014 12:51
  35. Although reperfusion injury has been shown to be responsible for cardiomyocytes death after an acute myocardial infarction, there is currently no drug on the market that reduces this type of injury. TRO40303 i...

    Authors: Sophie Le Lamer, Stéphanie Paradis, Hidayat Rahmouni, Corinne Chaimbault, Magali Michaud, Marcel Culcasi, Jean Afxantidis, Mathilde Latreille, Patrick Berna, Alain Berdeaux, Sylvia Pietri, Didier Morin, Yves Donazzolo, Jean-Louis Abitbol, Rebacca M Pruss and Sophie Schaller
    Citation: Journal of Translational Medicine 2014 12:38
  36. We aim to develop a rat model of veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

    Authors: Ayyaz A Ali, Peter Downey, Gopal Singh, Wei Qi, Isaac George, Hiroo Takayama, Ajay Kirtane, Prakash Krishnan, Adrian Zalewski, Darren Freed, Stephen R Large, Euan A Ashley, Martin B Leon, Matthew Bacchetta and Ziad A Ali
    Citation: Journal of Translational Medicine 2014 12:37
  37. Oxidative stress and DNA damage have been implicated in the pathogenesis of renovascular hypertension induced by renal artery stenosis in the two-kidney, one-clip (2K1C) Goldblatt model. Considering our previo...

    Authors: Ananda T Dias, Bianca P Rodrigues, Marcella L Porto, Agata L Gava, Camille M Balarini, Flavia P S Freitas, Zaira Palomino, Dulce E Casarini, Bianca P Campagnaro, Thiago M C Pereira, Silvana S Meyrelles and Elisardo C Vasquez
    Citation: Journal of Translational Medicine 2014 12:35
  38. Selenoprotein S (SelS) is an important endoplasmic reticulum and plasma membrane-located selenoprotein implicated in inflammatory responses and insulin resistance. However, the effects of SelS on endothelial c...

    Authors: Yin Zhao, Hua Li, Li-li Men, Rong-chong Huang, Hai-cheng Zhou, Qian Xing, Jun-jie Yao, Chun-hong Shi and Jian-ling Du
    Citation: Journal of Translational Medicine 2013 11:287
  39. Insulin resistance (IR) is frequently associated with endothelial dysfunction and has been proposed to play a major role in cardiovascular disease (CVD). On the other hand, obesity has long been related to IR ...

    Authors: Mariam El Assar, Juan Carlos Ruiz de Adana, Javier Angulo, María Luz Pindado Martínez, Alberto Hernández Matías and Leocadio Rodríguez-Mañas
    Citation: Journal of Translational Medicine 2013 11:263
  40. Notch signaling is known to be activated following myocardial ischemia, but its role in cardioprotection provided by ischemic preconditioning (IPC) and ischemic postconditioning (IPost) remains unclear.

    Authors: Xue-liang Zhou, Li Wan, Qi-rong Xu, Yong Zhao and Ji-chun Liu
    Citation: Journal of Translational Medicine 2013 11:251
  41. Angiotensin-converting enzyme 2 (ACE2), a monocarboxypeptidase which metabolizes angiotensin II (Ang II) to generate Ang-(1–7), has been shown to prevent cardiac hypertrophy and injury but the mechanism remain...

    Authors: Zhen-Zhou Zhang, Qian-Hui Shang, Hai-Yan Jin, Bei Song, Gavin Y Oudit, Lin Lu, Tong Zhou, Ying-Le Xu, Ping-Jin Gao, Ding-Liang Zhu, Josef M Penninger and Jiu-Chang Zhong
    Citation: Journal of Translational Medicine 2013 11:229
  42. The presence of endothelial dysfunction (ED) constitutes an early risk factor for cardiovascular disease (CVD) in children. Nitric oxide (NO) and endothelin (EDN) are generated in endothelial cells and are cri...

    Authors: Siriporn Chatsuriyawong, David Gozal, Leila Kheirandish-Gozal, Rakesh Bhattacharjee, Ahamed A Khalyfa, Yang Wang, Hakon Hakonarson, Brendan Keating, Wasana Sukhumsirichart and Abdelnaby Khalyfa
    Citation: Journal of Translational Medicine 2013 11:227
  43. Clinical studies have shown that radiotherapy increases the risk of cardiovascular disease at irradiated sites years after exposure. However, there is a lack of biological explanations in humans. We therefore ...

    Authors: Tinna Christersdottir Björklund, Sarah-Jayne Reilly, Caroline Gahm, Barbara Bottazzi, Alberto Mantovani, Per Tornvall and Martin Halle
    Citation: Journal of Translational Medicine 2013 11:223
  44. Previous study demonstrated that miR-133a was released into blood from injured myocardium in cardiovascular diseases. However, the dynamic change of circulating miR-133a level in the early phase of acute myoca...

    Authors: Feng Wang, Guangwen Long, Chunxia Zhao, Huaping Li, Sandip Chaugai, Yan Wang, Chen Chen and Dao Wen Wang
    Citation: Journal of Translational Medicine 2013 11:222
  45. M3 muscarinic acetylcholine receptor (M3-mAChR) is stably expressed in the myocardium, but its pathophysiological role remains largely undefined. This study aimed to investigate the role of M3-mAChR in cardiac hy...

    Authors: Yan Liu, Shu Wang, Chao Wang, Haoxin Song, Hongmei Han, Pengzhou Hang, Yanan Jiang, Lanlan Wei, Rong Huo, Lihua Sun, Xu Gao, Yanjie Lu and Zhimin Du
    Citation: Journal of Translational Medicine 2013 11:209
  46. Vascular smooth muscle cells (SMC) are central to arterial structure and function yet their involvement in the progression of abdominal aortic aneurysm (AAA) disease is not well studied. The progressive and si...

    Authors: Kirsten Riches, Timothy G Angelini, Gurprit S Mudhar, Jean Kaye, Emily Clark, Marc A Bailey, Soroush Sohrabi, Sotirios Korossis, Peter G Walker, D Julian A Scott and Karen E Porter
    Citation: Journal of Translational Medicine 2013 11:208
  47. Wall stress is a useful concept to understand the progression of ventricular remodeling. We measured cumulative LV wall stress throughout the cardiac cycle over unit time and tested whether this “integrated wa...

    Authors: Hailong Dong, Heather Mosca, Erhe Gao, Robert E Akins, Samuel S Gidding and Takeshi Tsuda
    Citation: Journal of Translational Medicine 2013 11:183

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