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Cardiovascular, Metabolic and Lipoprotein Translation

Section edited by Nehal N. Mehta and Tommaso Angelone
© Juan Gärtner/ stock.adob

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

Featured articles

Immune cell phenotyping in low blood volumes for assessment of cardiovascular disease risk, development, and progression: a pilot study

Research | Yvonne Baumer et al

Comprehensive analysis of differential immunocyte infiltration and the potential ceRNA networks during epicardial adipose tissue development in congenital heart disease

Research | Li Ma et al

Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration​​​​​​​

Research | Sharon F Wu et al

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  1. The prevalence of hyperuricemia has increased dramatically during the past several decades. Studies indicating uric acid is an independent risk factor for hypertension did not sufficiently control for other kn...

    Authors: Fengjiang Wei, Ning Sun, Chunyou Cai, Shuzhi Feng, Jianli Tian, Wentao Shi, Weili Xu, Yaogang Wang, Xilin Yang and Wei-Dong Li
    Citation: Journal of Translational Medicine 2016 14:110
  2. Mammalian microRNAs (miR) regulate the expression of genes relevant for the development of adaptive and innate immunity against cancer. Since T cell dysfunction has previously been reported in patients with re...

    Authors: Margherita Gigante, Paola Pontrelli, Wolfgang Herr, Maddalena Gigante, Morena D’Avenia, Gianluigi Zaza, Elisabetta Cavalcanti, Matteo Accetturo, Giuseppe Lucarelli, Giuseppe Carrieri, Michele Battaglia, Walter J. Storkus, Loreto Gesualdo and Elena Ranieri
    Citation: Journal of Translational Medicine 2016 14:84
  3. Energy metabolism disorder is a critical process in lung ischemia–reperfusion injury (LIRI). This study was aimed to determine the effects of resolvin D1 (RvD1) on the energy metabolism in LIRI.

    Authors: Qifeng Zhao, Ji Wu, Qingwang Hua, Zhiyong Lin, Leping Ye, Weixi Zhang, Guowei Wu, Jie Du, Jie Xia, Maoping Chu and Xingti Hu
    Citation: Journal of Translational Medicine 2016 14:81
  4. To explore whether plasma fatty acids and SNPs in the fatty acid desaturase (FADS) gene associated with type 2 diabetes (T2D) and coronary artery disease (CAD).

    Authors: Si-Wei Li, Jin Wang, Ying Yang, Zhi-Jie Liu, Lin Cheng, Huan-Yu Liu, Pei Ma, Wan Luo and Song-Mei Liu
    Citation: Journal of Translational Medicine 2016 14:79
  5. Aspirin resistance established by different laboratory methods is still a debated problem. Using COX1 specific methods no aspirin resistance was detected among healthy volunteers. Here we tested the effect of ...

    Authors: Nóra Homoródi, Emese G. Kovács, Sarolta Leé, Éva Katona, Amir H. Shemirani, Gizella Haramura, László Balogh, Zsuzsanna Bereczky, Gabriella Szőke, Hajna Péterfy, Róbert G. Kiss, István Édes and László Muszbek
    Citation: Journal of Translational Medicine 2016 14:74
  6. Lower leg ischemia, myopathy, and limb dysfunction are distinguishing features of peripheral artery disease (PAD). The myopathy of PAD is characterized by myofiber degeneration in association with extracellula...

    Authors: Duy M. Ha, Lauren C. Carpenter, Panagiotis Koutakis, Stanley A. Swanson, Zhen Zhu, Mina Hanna, Holly K. DeSpiegelaere, Iraklis I. Pipinos and George P. Casale
    Citation: Journal of Translational Medicine 2016 14:39
  7. Endothelial progenitor cells (EPCs) contribute to recanalization of deep vein thrombosis (DVT). This study aimed to detect miRNA expression profiles in EPCs from patients with DVT and characterize the role of ...

    Authors: Lingshang Kong, Nan Hu, Xiaolong Du, Wenbin Wang, Hong Chen, Wendong Li, Sen Wei, Hao Zhuang, Xiaoqiang Li and Chenglong Li
    Citation: Journal of Translational Medicine 2016 14:23
  8. Heart failure with ejection fraction (HFpEF) is a syndrome resulting from several co-morbidities in which specific mediators are unknown. The platelet proteome responds to disease processes. We hypothesize tha...

    Authors: Roseanne Raphael, Diana Purushotham, Courtney Gastonguay, Marla A. Chesnik, Wai-Meng Kwok, Hsiang-En Wu, Sanjiv J. Shah, Shama P. Mirza and Jennifer L. Strande
    Citation: Journal of Translational Medicine 2016 14:18
  9. Psoriasis patients exhibit an increased risk of atherothrombotic events, including myocardial infarction and stroke. Clinical evidence suggests that psoriasis patients with early onset and more severe disease ...

    Authors: Jackelyn B. Golden, Yunmei Wang, Yi Fritz, Doina Diaconu, Xiufen Zhang, Sara M. Debanne, Daniel I. Simon, Thomas S. McCormick and Nicole L. Ward
    Citation: Journal of Translational Medicine 2015 13:382
  10. XBP1 is a key transcription factor of the unfolded protein response in mammalian cells, which is involved in several cardiovascular pathological progression including cardiac hypertrophy and myocardial infarct...

    Authors: Quanlu Duan, Chen Chen, Lei Yang, Ni Li, Wei Gong, Sheng Li and Dao Wen Wang
    Citation: Journal of Translational Medicine 2015 13:363
  11. Gamma-glutamyltransferase (GGT) is a well-established independent risk factor for cardiovascular mortality related to atherosclerotic disease. Four GGT fractions have been identified in plasma, but only b-GGT ...

    Authors: Eugenia Belcastro, Maria Franzini, Silvana Cianchetti, Evelina Lorenzini, Silvia Masotti, Vanna Fierabracci, Angela Pucci, Alfonso Pompella and Alessandro Corti
    Citation: Journal of Translational Medicine 2015 13:325
  12. Inflammation mediated by nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of hypertensive nephropathy (HN). Cytoskeletal remodelling is necessary for the activation of NF-κB. An actin-bindin...

    Authors: Quan-zhen Wang, Hai-qing Gao, Ying Liang, Jun Zhang, Jian Wang and Jie Qiu
    Citation: Journal of Translational Medicine 2015 13:323
  13. Methionine sulfoxide reductase A (MsrA) is a potent intracellular oxidoreductase and serves as an essential factor that protects cells against oxidative damage. However, therapeutic use of exogenous MsrA in ox...

    Authors: Yao Wu, Guanghui Xie, Yanyong Xu, Li Ma, Chuanfeng Tong, Daping Fan, Fen Du and Hong Yu
    Citation: Journal of Translational Medicine 2015 13:316
  14. Circulating microRNAs may represent novel markers for cardiovascular diseases. We evaluated whether circulating miRNAs served as potential biomarkers for diffuse myocardial fibrosis in patients with hypertroph...

    Authors: Lu Fang, Andris H. Ellims, Xiao-lei Moore, David A. White, Andrew J. Taylor, Jaye Chin-Dusting and Anthony M. Dart
    Citation: Journal of Translational Medicine 2015 13:314
  15. From a pharmacological perspective, readily-available, well-characterized animal models of cardiovascular disease, including relevant in vivo markers of atherosclerosis are important for evaluation of novel dr...

    Authors: Trine Pagh Ludvigsen, Rikke Kaae Kirk, Berit Østergaard Christoffersen, Henrik Duelund Pedersen, Torben Martinussen, Jonas Kildegaard, Peter M. H. Heegaard, Jens Lykkesfeldt and Lisbeth Høier Olsen
    Citation: Journal of Translational Medicine 2015 13:312
  16. Energy loss (EL) was regarded to be one of the key parameters in predicting the rupture risk of IA. In this paper, we took varied aspect ratio (AR) as a scaling law to create a series of longitudinal models to...

    Authors: Yunling Long, Jingru Zhong, Hongyu Yu, Huagang Yan, Zhizheng Zhuo, Qianqian Meng, Xinjian Yang and Haiyun Li
    Citation: Journal of Translational Medicine 2015 13:311
  17. Heart failure (HF) is characterized by a series of adaptive changes in energy metabolism. The use of metabolomics enables the parallel assessment of a wide range of metabolites. In this study, we appraised whe...

    Authors: Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Emanuela Locci, Luigi Barberini, Federica Torri, Federica Ascedu, Luigi Atzori and Giuseppe Mercuro
    Citation: Journal of Translational Medicine 2015 13:297
  18. Apelin is an endogenous ligand for the G protein-coupled receptor APJ. The association between apelin and cardiac modeling has been reported. However, if serum apelin affect the left ventricular hypertrophy (L...

    Authors: Lijun Ye, Fenghua Ding, Liang Zhang, Anna Shen, Huaguo Yao, Liehua Deng and Yuanlin Ding
    Citation: Journal of Translational Medicine 2015 13:290
  19. Berberine (BBR), as a new medicine for hyperlipidemia, can reduce the blood lipids in patients. Mechanistic studies have shown that BBR activates the extracellular-signal regulated kinase pathway by stabilizin...

    Authors: Xiao-Yang Li, Zhen-Xiong Zhao, Min Huang, Ru Feng, Chi-Yu He, Chao Ma, Shi-Heng Luo, Jie Fu, Bao-Ying Wen, Long Ren, Jia-Wen Shou, Fang Guo, Yangchao Chen, Xin Gao, Yan Wang and Jian-Dong Jiang
    Citation: Journal of Translational Medicine 2015 13:278
  20. The aim of this study was to assess the relationship between extracorporeal blood flow (EBF) and left ventricular (LV) performance during venoarterial extracorporeal membrane oxygenation (VA ECMO) therapy.

    Authors: Petr Ostadal, Mikulas Mlcek, Andreas Kruger, Pavel Hala, Stanislav Lacko, Martin Mates, Dagmar Vondrakova, Tomas Svoboda, Matej Hrachovina, Marek Janotka, Hana Psotova, Svitlana Strunina, Otomar Kittnar and Petr Neuzil
    Citation: Journal of Translational Medicine 2015 13:266
  21. The renin-angiotensin system (RAS) has been implicated in atherosclerotic lesions and progression to chronic kidney diseases. We examined regulatory roles of angiotensin-converting enzyme 2 (ACE2) in the apoli...

    Authors: Hai-Yan Jin, Lai-Jiang Chen, Zhen-Zhou Zhang, Ying-Le Xu, Bei Song, Ran Xu, Gavin Y Oudit, Ping-Jin Gao, Ding-Liang Zhu and Jiu-Chang Zhong
    Citation: Journal of Translational Medicine 2015 13:255
  22. Metabolic derangement is a key hallmark of major traumatic injury. The recent introduction of mass spectrometry-based metabolomics technologies in the field of trauma shed new light on metabolic aberrations in...

    Authors: Angelo D’Alessandro, Annie L Slaughter, Erik D Peltz, Ernest E Moore, Christopher C Silliman, Matthew Wither, Travis Nemkov, Anthony W Bacon, Miguel Fragoso, Anirban Banerjee and Kirk C Hansen
    Citation: Journal of Translational Medicine 2015 13:253
  23. Inflammation is a key etiologic component in atherogenesis. Previously we demonstrated that adeno-associated virus (AAV) 2/8 gene delivery of Netrin1 inhibited atherosclerosis in the low density lipoprotein re...

    Authors: M Cao, S A Theus, K D Straub, J A Figueroa, L Mirandola, M Chiriva-Internati and P L Hermonat
    Citation: Journal of Translational Medicine 2015 13:235
  24. Febuxostat is a selective inhibitor of xanthine oxidase (XO). XO is a critical source of reactive oxygen species (ROS) during myocardial ischemia/reperfusion (I/R) injury. Inhibition of XO is therapeutically e...

    Authors: Shulin Wang, Yunpeng Li, Xudong Song, Xianbao Wang, Cong Zhao, Aihua Chen and Pingzhen Yang
    Citation: Journal of Translational Medicine 2015 13:209
  25. Atherosclerosis (AS) presents characteristic of a chronic inflammatory disease in which both adaptive and innate immune cells play roles. Accumulating evidence has showed the impairment of natural killer (NK) ...

    Authors: Jin Zuo, Zhaoliang Shan, Lin Zhou, Jian Yu, Xiaopeng Liu and Yuan Gao
    Citation: Journal of Translational Medicine 2015 13:188
  26. Although the incidence of acute death related to coronary artery disease has decreased with the advent of new interventional therapies, myocardial infarction remains one of the leading causes of death in the U...

    Authors: Derek W Hanes, Maelene L Wong, C W Jenny Chang, Sterling Humphrey, J Kevin Grayson, Walter D Boyd and Leigh G Griffiths
    Citation: Journal of Translational Medicine 2015 13:187
  27. Recent experimental and clinical studies have indicated the cardioprotective role of sildenafil during ischemia/reperfusion (I/R) injury. Sildenafil has been shown to attenuate postresuscitation myocardial dys...

    Authors: Qian Zhang, Guoxing Wang, Wei Yuan, Junyuan Wu, Miaomiao Wang and ChunSheng Li
    Citation: Journal of Translational Medicine 2015 13:177
  28. Jiangzhi Capsule is an Australian listed patented traditional Chinese medicine and has been used for management of lipid abnormalities over the past 10 years. To obtain a better understanding r...

    Authors: Yuanyang Zhao, Yongquan Pan, Yifan Yang, Robert Batey, Jianwei Wang and Yuhao Li
    Citation: Journal of Translational Medicine 2015 13:174
  29. We investigated whether attenuating dipeptidyl peptidase-IV (DPP4) enzyme activity protected rat heart from ischemia-reperfusion (IR) injury (40-min left anterior descending coronary artery ligation followed by 7...

    Authors: Sarah Chua, Fan-Yen Lee, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Steve Leu, Cheuk-Kwan Sun, Yung-Lung Chen, Hsueh-Wen Chang, Han-Tan Chai, Chu-Feng Liu, Hung-I Lu and Hon-Kan Yip
    Citation: Journal of Translational Medicine 2014 12:357
  30. Aldosterone synthase inhibition provides the potential to attenuate both the mineralocorticoid receptor-dependent and independent actions of aldosterone. In vitro studies with recombinant human enzymes showed LCI...

    Authors: Joël Ménard, Dean F Rigel, Catherine Watson, Arco Y Jeng, Fumin Fu, Michael Beil, Jing Liu, Wei Chen, Chii-Whei Hu, Jennifer Leung-Chu, Daniel LaSala, Guiqing Liang, Sam Rebello, Yiming Zhang and William P Dole
    Citation: Journal of Translational Medicine 2014 12:340
  31. Glycated hemoglobin A1c (HbA1c) has been used as an index of glycemic control in the management, guidance, and clinical trials of diabetic patients for the past 35 years. The aim of this study was to validate the...

    Authors: Piotr Ladyzynski, Piotr Foltynski, Marianna I Bak, Stanislawa Sabalinska, Janusz Krzymien and Jerzy Kawiak
    Citation: Journal of Translational Medicine 2014 12:328
  32. Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to the various effects of steroids on multi-system pathways involved into osteoblast differentiation, oste...

    Authors: Yini Jiang, Yanqiong Zhang, Weiheng Chen, Chunfang Liu, Xiaomin Li, Danni Sun, Zhenli Liu, Ying Xu, Xia Mao, Qiuyan Guo and Na Lin
    Citation: Journal of Translational Medicine 2014 12:334

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:208

  33. Acute, high-dose folic acid (FA) administration has recently been shown to possess unprecedented effective cardioprotection against ischaemia/reperfusion (I/R) injury. Here we explore the translation potential...

    Authors: Coert J Zuurbier, Andre Heinen, Anneke Koeman, Roy Stuifbergen, Theodorus BM Hakvoort, Nina C Weber and Markus W Hollmann
    Citation: Journal of Translational Medicine 2014 12:325
  34. Our previous in vitro and clinical work has demonstrated anti-inflammatory effects of berberine (BBR), but the clinical application of BBR is limited by its poor bioavailability. Derivatives of BBR have been sugg...

    Authors: Junwen Chen, Jiatian Cao, Lu Fang, Bo Liu, Qing Zhou, Yinggang Sun, Yue Wang, Yigang Li and Shu Meng
    Citation: Journal of Translational Medicine 2014 12:326
  35. Hordeum vulgare L. (HV or barley) is used by traditional healers to treat various inflammatory and cardiovascular diseases, without the knowledge of pharmacologic rationale behind its actions. This study was des...

    Authors: Saima Gul, Sagheer Ahmed, Nurolaini Kifli, Qazi Tahir Uddin, Nafisa Batool Tahir, Abrar Hussain, Hawa ZE Jaafar, Marius Moga and Muhammad Zia-Ul-Haq
    Citation: Journal of Translational Medicine 2014 12:316
  36. Patients with pulmonary arterial hypertension (PAH) are treated with vasodilators, including endothelin receptor antagonists (ERAs), phosphodiesterase-5 (PDE-5) inhibitors, soluble guanylyl cyclase activators,...

    Authors: Maria A Cavasin, Kimberly M Demos-Davies, Katherine B Schuetze, Weston W Blakeslee, Matthew S Stratton, Rubin M Tuder and Timothy A McKinsey
    Citation: Journal of Translational Medicine 2014 12:314
  37. Nonalcoholic steatohepatitis (NASH), the advanced stage of nonalcoholic fatty liver disease that is characterized by both steatosis and severe injury in liver, still lacks efficient treatment. The traditional ...

    Authors: Yang Liu, Haiyan Song, Lei Wang, Hanchen Xu, Xiangbing Shu, Li Zhang, Ying Li, Dongfei Li and Guang Ji
    Citation: Journal of Translational Medicine 2014 12:315
  38. Autonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to the progression of heart failure (HF). We hypothesized that chronic vagus nerve stimulation (VNS) could preve...

    Authors: Haiwen Yu, Min Tang, Jun Yu, Xiaohong Zhou, Lepeng Zeng and Shu Zhang
    Citation: Journal of Translational Medicine 2014 12:302
  39. Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic disease, inc...

    Authors: Xin-chen Xu, Hui Chen, Xi Zhang, Zan-jing Zhai, Xu-qiang Liu, An Qin and Er-yi Lu
    Citation: Journal of Translational Medicine 2014 12:284
  40. In coronary arteries, plaque disruption, the major acute clinical manifestations of atherosclerosis, leads to a subsequent cardiac event, such as acute myocardial infarction (AMI) and unstable angina pectoris ...

    Authors: Jiatian Cao, Zhihua Han, Lei Tian, Kan Chen, Yuqi Fan, Bozhi Ye, Weijian Huang, Changqian Wang and Zhouqing Huang
    Citation: Journal of Translational Medicine 2014 12:266
  41. Adipose tissue normally contains immune cells that regulate adipocyte function and contribute to metabolic disorders including obesity and diabetes mellitus. Psoriasis is associated with increased risk for met...

    Authors: Shawn Rose, Elena Stansky, Pradeep K Dagur, Leigh Samsel, Elizabeth Weiner, Amir Jahanshad, Julia Doveikis, Haley B Naik, Martin P Playford, J Philip McCoy and Nehal N Mehta
    Citation: Journal of Translational Medicine 2014 12:258
  42. The clipping of an artery supplying one of the two kidneys (2K1C) activates the renin-angiotensin (Ang) system (RAS), resulting in hypertension and endothelial dysfunction. Recently, we demonstrated the intrar...

    Authors: Ananda T Dias, Amanda S Cintra, Jéssica C Frossard, Zaira Palomino, Dulce E Casarini, Isabele BS Gomes, Camille M Balarini, Agata L Gava, Bianca P Campagnaro, Thiago MC Pereira, Silvana S Meyrelles and Elisardo C Vasquez
    Citation: Journal of Translational Medicine 2014 12:250
  43. Postural tachycardia syndrome (POTS) is a heterogeneous disorder that creates challenges for treatment. Beta-blocker was one of the most commonly used drugs, but it is inconsistently effective. The purpose of ...

    Authors: Qingyou Zhang, Xia Chen, Jiawei Li and Junbao Du
    Citation: Journal of Translational Medicine 2014 12:249
  44. Salvia-Nelumbinis naturalis (SNN), initially called Jiangzhi Granula as a formulae of Chinese medicinal decoction, has been used clinically to treat non-alcoholic fatty liver disease (NAFLD) and related syndro...

    Authors: Li Zhang, Jiaoya Xu, Haiyan Song, Zemin Yao and Guang Ji
    Citation: Journal of Translational Medicine 2014 12:236
  45. Peroxisome proliferator-activated receptor gamma-2 gene (PPARγ2) rs1801282 (Pro12Ala) polymorphism has been associated with lower risk of metabolic disturbance and atherosclerosis. The aim of this study was to an...

    Authors: Pilar García-Broncano, Juan Berenguer, Amanda Fernández-Rodríguez, Daniel Pineda-Tenor, María Ángeles Jiménez-Sousa, Mónica García–Alvarez, Pilar Miralles, Teresa Aldámiz-Echevarria, Juan Carlos López, Dariela Micheloud and Salvador Resino
    Citation: Journal of Translational Medicine 2014 12:235
  46. Remote ischemic preconditioning (RIPC) protects the heart from ischemia and reperfusion (I/R) injury. The underlying molecular mechanisms are unclear. It has been demonstrated that Connexin 43 (Cx43) is critic...

    Authors: Timo Brandenburger, Ragnar Huhn, Andreas Galas, Benedikt H Pannen, Verena Keitel, Franziska Barthel, Inge Bauer and André Heinen
    Citation: Journal of Translational Medicine 2014 12:228
  47. Relative hypovolemia is frequently found in early stages of severe sepsis and septic shock and prompt and aggressive fluid therapy has become standard of care improving tissue perfusion and patient outcome. Th...

    Authors: Nivaldo Ribeiro Villela, Ana Olimpia Maia Teixeira dos Santos, Marcos Lopes de Miranda and Eliete Bouskela
    Citation: Journal of Translational Medicine 2014 12:232
  48. Atherosclerosis is a chronic inflammatory process of the vessel walls, and CD4+ T-cells are peculiar to both human and murine atherosclerotic lesions. There is a recent line of research favoring hypothetic allerg...

    Authors: Giovanni Tarantino, Susan Costantini, Carmine Finelli, Francesca Capone, Eliana Guerriero, Nicolina La Sala, Saverio Gioia and Giuseppe Castello
    Citation: Journal of Translational Medicine 2014 12:214
  49. BAG3 gene mutations have been recently implicated as a novel cause of dilated cardiomyopathy (DCM). Our aim was to evaluate the prevalence of BAG3 mutations in Polish patients with DCM and to search for genotype...

    Authors: Maria Franaszczyk, Zofia T Bilinska, Małgorzata Sobieszczańska-Małek, Ewa Michalak, Justyna Sleszycka, Agnieszka Sioma, Łukasz A Małek, Dorota Kaczmarska, Ewa Walczak, Paweł Włodarski, Łukasz Hutnik, Blanka Milanowska, Zofia Dzielinska, Grzegorz Religa, Jacek Grzybowski, Tomasz Zieliński…
    Citation: Journal of Translational Medicine 2014 12:192

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