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Cardiovascular, metabolic and Lipoprotein translation

Section edited by Nehal N. Mehta

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

Featured articles

Transforming growth factor-beta 1 produced by vascular smooth muscle cells predicts fibrosis in the gastrocnemius of patients with peripheral artery disease
Duy M. Ha, et al

Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction
Roseanne Raphael, et al

Chronic, not acute, skin-specific inflammation promotes thrombosis in psoriasis murine models.
Jackelyn B. Golden, et al

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  1. Psoriasis patients exhibit an increased risk of atherothrombotic events, including myocardial infarction and stroke. Clinical evidence suggests that psoriasis patients with early onset and more severe disease ...

    Authors: Jackelyn B. Golden, Yunmei Wang, Yi Fritz, Doina Diaconu, Xiufen Zhang, Sara M. Debanne, Daniel I. Simon, Thomas S. McCormick and Nicole L. Ward

    Citation: Journal of Translational Medicine 2015 13:382

    Content type: Research

    Published on:

  2. XBP1 is a key transcription factor of the unfolded protein response in mammalian cells, which is involved in several cardiovascular pathological progression including cardiac hypertrophy and myocardial infarct...

    Authors: Quanlu Duan, Chen Chen, Lei Yang, Ni Li, Wei Gong, Sheng Li and Dao Wen Wang

    Citation: Journal of Translational Medicine 2015 13:363

    Content type: Research

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  3. Gamma-glutamyltransferase (GGT) is a well-established independent risk factor for cardiovascular mortality related to atherosclerotic disease. Four GGT fractions have been identified in plasma, but only b-GGT ...

    Authors: Eugenia Belcastro, Maria Franzini, Silvana Cianchetti, Evelina Lorenzini, Silvia Masotti, Vanna Fierabracci, Angela Pucci, Alfonso Pompella and Alessandro Corti

    Citation: Journal of Translational Medicine 2015 13:325

    Content type: Research

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  4. Inflammation mediated by nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of hypertensive nephropathy (HN). Cytoskeletal remodelling is necessary for the activation of NF-κB. An actin-bindin...

    Authors: Quan-zhen Wang, Hai-qing Gao, Ying Liang, Jun Zhang, Jian Wang and Jie Qiu

    Citation: Journal of Translational Medicine 2015 13:323

    Content type: Research

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  5. Methionine sulfoxide reductase A (MsrA) is a potent intracellular oxidoreductase and serves as an essential factor that protects cells against oxidative damage. However, therapeutic use of exogenous MsrA in ox...

    Authors: Yao Wu, Guanghui Xie, Yanyong Xu, Li Ma, Chuanfeng Tong, Daping Fan, Fen Du and Hong Yu

    Citation: Journal of Translational Medicine 2015 13:316

    Content type: Research

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  6. Circulating microRNAs may represent novel markers for cardiovascular diseases. We evaluated whether circulating miRNAs served as potential biomarkers for diffuse myocardial fibrosis in patients with hypertroph...

    Authors: Lu Fang, Andris H. Ellims, Xiao-lei Moore, David A. White, Andrew J. Taylor, Jaye Chin-Dusting and Anthony M. Dart

    Citation: Journal of Translational Medicine 2015 13:314

    Content type: Research

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  7. From a pharmacological perspective, readily-available, well-characterized animal models of cardiovascular disease, including relevant in vivo markers of atherosclerosis are important for evaluation of novel dr...

    Authors: Trine Pagh Ludvigsen, Rikke Kaae Kirk, Berit Østergaard Christoffersen, Henrik Duelund Pedersen, Torben Martinussen, Jonas Kildegaard, Peter M. H. Heegaard, Jens Lykkesfeldt and Lisbeth Høier Olsen

    Citation: Journal of Translational Medicine 2015 13:312

    Content type: Research

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  8. Energy loss (EL) was regarded to be one of the key parameters in predicting the rupture risk of IA. In this paper, we took varied aspect ratio (AR) as a scaling law to create a series of longitudinal models to...

    Authors: Yunling Long, Jingru Zhong, Hongyu Yu, Huagang Yan, Zhizheng Zhuo, Qianqian Meng, Xinjian Yang and Haiyun Li

    Citation: Journal of Translational Medicine 2015 13:311

    Content type: Research

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  9. Heart failure (HF) is characterized by a series of adaptive changes in energy metabolism. The use of metabolomics enables the parallel assessment of a wide range of metabolites. In this study, we appraised whe...

    Authors: Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Emanuela Locci, Luigi Barberini, Federica Torri, Federica Ascedu, Luigi Atzori and Giuseppe Mercuro

    Citation: Journal of Translational Medicine 2015 13:297

    Content type: Research

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  11. Apelin is an endogenous ligand for the G protein-coupled receptor APJ. The association between apelin and cardiac modeling has been reported. However, if serum apelin affect the left ventricular hypertrophy (L...

    Authors: Lijun Ye, Fenghua Ding, Liang Zhang, Anna Shen, Huaguo Yao, Liehua Deng and Yuanlin Ding

    Citation: Journal of Translational Medicine 2015 13:290

    Content type: Research

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  12. Berberine (BBR), as a new medicine for hyperlipidemia, can reduce the blood lipids in patients. Mechanistic studies have shown that BBR activates the extracellular-signal regulated kinase pathway by stabilizin...

    Authors: Xiao-Yang Li, Zhen-Xiong Zhao, Min Huang, Ru Feng, Chi-Yu He, Chao Ma, Shi-Heng Luo, Jie Fu, Bao-Ying Wen, Long Ren, Jia-Wen Shou, Fang Guo, Yangchao Chen, Xin Gao, Yan Wang and Jian-Dong Jiang

    Citation: Journal of Translational Medicine 2015 13:278

    Content type: Research

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  13. The aim of this study was to assess the relationship between extracorporeal blood flow (EBF) and left ventricular (LV) performance during venoarterial extracorporeal membrane oxygenation (VA ECMO) therapy.

    Authors: Petr Ostadal, Mikulas Mlcek, Andreas Kruger, Pavel Hala, Stanislav Lacko, Martin Mates, Dagmar Vondrakova, Tomas Svoboda, Matej Hrachovina, Marek Janotka, Hana Psotova, Svitlana Strunina, Otomar Kittnar and Petr Neuzil

    Citation: Journal of Translational Medicine 2015 13:266

    Content type: Research

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  14. The renin-angiotensin system (RAS) has been implicated in atherosclerotic lesions and progression to chronic kidney diseases. We examined regulatory roles of angiotensin-converting enzyme 2 (ACE2) in the apoli...

    Authors: Hai-Yan Jin, Lai-Jiang Chen, Zhen-Zhou Zhang, Ying-Le Xu, Bei Song, Ran Xu, Gavin Y Oudit, Ping-Jin Gao, Ding-Liang Zhu and Jiu-Chang Zhong

    Citation: Journal of Translational Medicine 2015 13:255

    Content type: Research

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  15. Metabolic derangement is a key hallmark of major traumatic injury. The recent introduction of mass spectrometry-based metabolomics technologies in the field of trauma shed new light on metabolic aberrations in...

    Authors: Angelo D’Alessandro, Annie L Slaughter, Erik D Peltz, Ernest E Moore, Christopher C Silliman, Matthew Wither, Travis Nemkov, Anthony W Bacon, Miguel Fragoso, Anirban Banerjee and Kirk C Hansen

    Citation: Journal of Translational Medicine 2015 13:253

    Content type: Research

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  16. Inflammation is a key etiologic component in atherogenesis. Previously we demonstrated that adeno-associated virus (AAV) 2/8 gene delivery of Netrin1 inhibited atherosclerosis in the low density lipoprotein re...

    Authors: M Cao, S A Theus, K D Straub, J A Figueroa, L Mirandola, M Chiriva-Internati and P L Hermonat

    Citation: Journal of Translational Medicine 2015 13:235

    Content type: Research

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  17. Febuxostat is a selective inhibitor of xanthine oxidase (XO). XO is a critical source of reactive oxygen species (ROS) during myocardial ischemia/reperfusion (I/R) injury. Inhibition of XO is therapeutically e...

    Authors: Shulin Wang, Yunpeng Li, Xudong Song, Xianbao Wang, Cong Zhao, Aihua Chen and Pingzhen Yang

    Citation: Journal of Translational Medicine 2015 13:209

    Content type: Research

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  18. Atherosclerosis (AS) presents characteristic of a chronic inflammatory disease in which both adaptive and innate immune cells play roles. Accumulating evidence has showed the impairment of natural killer (NK) ...

    Authors: Jin Zuo, Zhaoliang Shan, Lin Zhou, Jian Yu, Xiaopeng Liu and Yuan Gao

    Citation: Journal of Translational Medicine 2015 13:188

    Content type: Research

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  19. Although the incidence of acute death related to coronary artery disease has decreased with the advent of new interventional therapies, myocardial infarction remains one of the leading causes of death in the U...

    Authors: Derek W Hanes, Maelene L Wong, C W Jenny Chang, Sterling Humphrey, J Kevin Grayson, Walter D Boyd and Leigh G Griffiths

    Citation: Journal of Translational Medicine 2015 13:187

    Content type: Research

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  20. Recent experimental and clinical studies have indicated the cardioprotective role of sildenafil during ischemia/reperfusion (I/R) injury. Sildenafil has been shown to attenuate postresuscitation myocardial dys...

    Authors: Qian Zhang, Guoxing Wang, Wei Yuan, Junyuan Wu, Miaomiao Wang and ChunSheng Li

    Citation: Journal of Translational Medicine 2015 13:177

    Content type: Research

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  21. Jiangzhi Capsule is an Australian listed patented traditional Chinese medicine and has been used for management of lipid abnormalities over the past 10 years. To obtain a better understanding r...

    Authors: Yuanyang Zhao, Yongquan Pan, Yifan Yang, Robert Batey, Jianwei Wang and Yuhao Li

    Citation: Journal of Translational Medicine 2015 13:174

    Content type: Research

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  22. We investigated whether attenuating dipeptidyl peptidase-IV (DPP4) enzyme activity protected rat heart from ischemia-reperfusion (IR) injury (40-min left anterior descending coronary artery ligation followed by 7...

    Authors: Sarah Chua, Fan-Yen Lee, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Steve Leu, Cheuk-Kwan Sun, Yung-Lung Chen, Hsueh-Wen Chang, Han-Tan Chai, Chu-Feng Liu, Hung-I Lu and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2014 12:357

    Content type: Research

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  23. Aldosterone synthase inhibition provides the potential to attenuate both the mineralocorticoid receptor-dependent and independent actions of aldosterone. In vitro studies with recombinant human enzymes showed LCI...

    Authors: Joël Ménard, Dean F Rigel, Catherine Watson, Arco Y Jeng, Fumin Fu, Michael Beil, Jing Liu, Wei Chen, Chii-Whei Hu, Jennifer Leung-Chu, Daniel LaSala, Guiqing Liang, Sam Rebello, Yiming Zhang and William P Dole

    Citation: Journal of Translational Medicine 2014 12:340

    Content type: Research

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  24. Glycated hemoglobin A1c (HbA1c) has been used as an index of glycemic control in the management, guidance, and clinical trials of diabetic patients for the past 35 years. The aim of this study was to validate the...

    Authors: Piotr Ladyzynski, Piotr Foltynski, Marianna I Bak, Stanislawa Sabalinska, Janusz Krzymien and Jerzy Kawiak

    Citation: Journal of Translational Medicine 2014 12:328

    Content type: Research

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  25. Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to the various effects of steroids on multi-system pathways involved into osteoblast differentiation, oste...

    Authors: Yini Jiang, Yanqiong Zhang, Weiheng Chen, Chunfang Liu, Xiaomin Li, Danni Sun, Zhenli Liu, Ying Xu, Xia Mao, Qiuyan Guo and Na Lin

    Citation: Journal of Translational Medicine 2014 12:334

    Content type: Research

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  26. Acute, high-dose folic acid (FA) administration has recently been shown to possess unprecedented effective cardioprotection against ischaemia/reperfusion (I/R) injury. Here we explore the translation potential...

    Authors: Coert J Zuurbier, Andre Heinen, Anneke Koeman, Roy Stuifbergen, Theodorus BM Hakvoort, Nina C Weber and Markus W Hollmann

    Citation: Journal of Translational Medicine 2014 12:325

    Content type: Research

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  27. Our previous in vitro and clinical work has demonstrated anti-inflammatory effects of berberine (BBR), but the clinical application of BBR is limited by its poor bioavailability. Derivatives of BBR have been sugg...

    Authors: Junwen Chen, Jiatian Cao, Lu Fang, Bo Liu, Qing Zhou, Yinggang Sun, Yue Wang, Yigang Li and Shu Meng

    Citation: Journal of Translational Medicine 2014 12:326

    Content type: Research

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  28. Hordeum vulgare L. (HV or barley) is used by traditional healers to treat various inflammatory and cardiovascular diseases, without the knowledge of pharmacologic rationale behind its actions. This study was des...

    Authors: Saima Gul, Sagheer Ahmed, Nurolaini Kifli, Qazi Tahir Uddin, Nafisa Batool Tahir, Abrar Hussain, Hawa ZE Jaafar, Marius Moga and Muhammad Zia-Ul-Haq

    Citation: Journal of Translational Medicine 2014 12:316

    Content type: Research

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  29. Patients with pulmonary arterial hypertension (PAH) are treated with vasodilators, including endothelin receptor antagonists (ERAs), phosphodiesterase-5 (PDE-5) inhibitors, soluble guanylyl cyclase activators,...

    Authors: Maria A Cavasin, Kimberly M Demos-Davies, Katherine B Schuetze, Weston W Blakeslee, Matthew S Stratton, Rubin M Tuder and Timothy A McKinsey

    Citation: Journal of Translational Medicine 2014 12:314

    Content type: Research

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  30. Nonalcoholic steatohepatitis (NASH), the advanced stage of nonalcoholic fatty liver disease that is characterized by both steatosis and severe injury in liver, still lacks efficient treatment. The traditional ...

    Authors: Yang Liu, Haiyan Song, Lei Wang, Hanchen Xu, Xiangbing Shu, Li Zhang, Ying Li, Dongfei Li and Guang Ji

    Citation: Journal of Translational Medicine 2014 12:315

    Content type: Research

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  31. Autonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to the progression of heart failure (HF). We hypothesized that chronic vagus nerve stimulation (VNS) could preve...

    Authors: Haiwen Yu, Min Tang, Jun Yu, Xiaohong Zhou, Lepeng Zeng and Shu Zhang

    Citation: Journal of Translational Medicine 2014 12:302

    Content type: Research

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  32. Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic disease, inc...

    Authors: Xin-chen Xu, Hui Chen, Xi Zhang, Zan-jing Zhai, Xu-qiang Liu, An Qin and Er-yi Lu

    Citation: Journal of Translational Medicine 2014 12:284

    Content type: Research

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  33. In coronary arteries, plaque disruption, the major acute clinical manifestations of atherosclerosis, leads to a subsequent cardiac event, such as acute myocardial infarction (AMI) and unstable angina pectoris ...

    Authors: Jiatian Cao, Zhihua Han, Lei Tian, Kan Chen, Yuqi Fan, Bozhi Ye, Weijian Huang, Changqian Wang and Zhouqing Huang

    Citation: Journal of Translational Medicine 2014 12:266

    Content type: Research

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  34. Adipose tissue normally contains immune cells that regulate adipocyte function and contribute to metabolic disorders including obesity and diabetes mellitus. Psoriasis is associated with increased risk for met...

    Authors: Shawn Rose, Elena Stansky, Pradeep K Dagur, Leigh Samsel, Elizabeth Weiner, Amir Jahanshad, Julia Doveikis, Haley B Naik, Martin P Playford, J Philip McCoy and Nehal N Mehta

    Citation: Journal of Translational Medicine 2014 12:258

    Content type: Research

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  35. The clipping of an artery supplying one of the two kidneys (2K1C) activates the renin-angiotensin (Ang) system (RAS), resulting in hypertension and endothelial dysfunction. Recently, we demonstrated the intrar...

    Authors: Ananda T Dias, Amanda S Cintra, Jéssica C Frossard, Zaira Palomino, Dulce E Casarini, Isabele BS Gomes, Camille M Balarini, Agata L Gava, Bianca P Campagnaro, Thiago MC Pereira, Silvana S Meyrelles and Elisardo C Vasquez

    Citation: Journal of Translational Medicine 2014 12:250

    Content type: Research

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  36. Postural tachycardia syndrome (POTS) is a heterogeneous disorder that creates challenges for treatment. Beta-blocker was one of the most commonly used drugs, but it is inconsistently effective. The purpose of ...

    Authors: Qingyou Zhang, Xia Chen, Jiawei Li and Junbao Du

    Citation: Journal of Translational Medicine 2014 12:249

    Content type: Research

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  37. Salvia-Nelumbinis naturalis (SNN), initially called Jiangzhi Granula as a formulae of Chinese medicinal decoction, has been used clinically to treat non-alcoholic fatty liver disease (NAFLD) and related syndro...

    Authors: Li Zhang, Jiaoya Xu, Haiyan Song, Zemin Yao and Guang Ji

    Citation: Journal of Translational Medicine 2014 12:236

    Content type: Research

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  38. Peroxisome proliferator-activated receptor gamma-2 gene (PPARγ2) rs1801282 (Pro12Ala) polymorphism has been associated with lower risk of metabolic disturbance and atherosclerosis. The aim of this study was to an...

    Authors: Pilar García-Broncano, Juan Berenguer, Amanda Fernández-Rodríguez, Daniel Pineda-Tenor, María Ángeles Jiménez-Sousa, Mónica García–Alvarez, Pilar Miralles, Teresa Aldámiz-Echevarria, Juan Carlos López, Dariela Micheloud and Salvador Resino

    Citation: Journal of Translational Medicine 2014 12:235

    Content type: Research

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  39. Remote ischemic preconditioning (RIPC) protects the heart from ischemia and reperfusion (I/R) injury. The underlying molecular mechanisms are unclear. It has been demonstrated that Connexin 43 (Cx43) is critic...

    Authors: Timo Brandenburger, Ragnar Huhn, Andreas Galas, Benedikt H Pannen, Verena Keitel, Franziska Barthel, Inge Bauer and André Heinen

    Citation: Journal of Translational Medicine 2014 12:228

    Content type: Research

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  40. Relative hypovolemia is frequently found in early stages of severe sepsis and septic shock and prompt and aggressive fluid therapy has become standard of care improving tissue perfusion and patient outcome. Th...

    Authors: Nivaldo Ribeiro Villela, Ana Olimpia Maia Teixeira dos Santos, Marcos Lopes de Miranda and Eliete Bouskela

    Citation: Journal of Translational Medicine 2014 12:232

    Content type: Research

    Published on:

  41. Atherosclerosis is a chronic inflammatory process of the vessel walls, and CD4+ T-cells are peculiar to both human and murine atherosclerotic lesions. There is a recent line of research favoring hypothetic allerg...

    Authors: Giovanni Tarantino, Susan Costantini, Carmine Finelli, Francesca Capone, Eliana Guerriero, Nicolina La Sala, Saverio Gioia and Giuseppe Castello

    Citation: Journal of Translational Medicine 2014 12:214

    Content type: Research

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  42. BAG3 gene mutations have been recently implicated as a novel cause of dilated cardiomyopathy (DCM). Our aim was to evaluate the prevalence of BAG3 mutations in Polish patients with DCM and to search for genotype...

    Authors: Maria Franaszczyk, Zofia T Bilinska, Małgorzata Sobieszczańska-Małek, Ewa Michalak, Justyna Sleszycka, Agnieszka Sioma, Łukasz A Małek, Dorota Kaczmarska, Ewa Walczak, Paweł Włodarski, Łukasz Hutnik, Blanka Milanowska, Zofia Dzielinska, Grzegorz Religa, Jacek Grzybowski, Tomasz Zieliński…

    Citation: Journal of Translational Medicine 2014 12:192

    Content type: Research

    Published on:

  43. Experimental and human studies have demonstrated that innate immune mechanisms and consequent inflammatory reaction play a critical role in cardiac response to ischemic injury. Thus, the detection of immuno-in...

    Authors: Emanuela Turillazzi, Marco Di Paolo, Margherita Neri, Irene Riezzo and Vittorio Fineschi

    Citation: Journal of Translational Medicine 2014 12:188

    Content type: Research

    Published on:

  44. Cardiac gene therapy for heart disease is a major translational research area with potential, yet problems with safe and efficient gene transfer into cardiac muscle remain unresolved. Existing methodology to i...

    Authors: Anthony S Fargnoli, Anbin Mu, Michael G Katz, Richard D Williams, Kenneth B Margulies, David B Weiner, Shu Yang and Charles R Bridges

    Citation: Journal of Translational Medicine 2014 12:171

    Content type: Methodology

    Published on:

  45. Circulating endothelial progenitor cells (EPCs) may be a biomarker for vascular function and cardiovascular risk in patients with coronary artery disease (CAD). Dimethylarginine dimethylaminohydrolase 2 (DDAH2...

    Authors: Pan-Pan Niu, Yu Cao, Ting Gong, Jin-Hui Guo, Bi-Kui Zhang and Su-Jie Jia

    Citation: Journal of Translational Medicine 2014 12:170

    Content type: Research

    Published on:

  46. Consecutive treatment of normal heart with a high dose of isoproterenol and adenosine (Iso/Ade treatment), confers strong protection against ischaemia/reperfusion injury. In preparation for translation of this...

    Authors: Igor Khaliulin, Andrew P Halestrap, Simon M Bryant, Declan J Dudley, Andrew F James and M-Saadeh Suleiman

    Citation: Journal of Translational Medicine 2014 12:139

    Content type: Research

    Published on:

  47. Despite recent advances, myocardial infarction (MI) remains the leading cause of death worldwide. Pre-clinical animal models that closely mimic human MI are pivotal for a quick translation of research and swin...

    Authors: Carolina Gálvez-Montón, Cristina Prat-Vidal, Idoia Díaz-Güemes, Verónica Crisóstomo, Carolina Soler-Botija, Santiago Roura, Aida Llucià-Valldeperas, Isaac Perea-Gil, Francisco M Sánchez-Margallo and Antoni Bayes-Genis

    Citation: Journal of Translational Medicine 2014 12:137

    Content type: Research

    Published on:

  48. The addition of an intra-aortic balloon pump (IABP) during peripheral venoarterial extracorporeal membrane oxygenation (VA ECMO) support has been shown to improve coronary bypass graft flows and cardiac functi...

    Authors: Feng Yang, Zai-shen Jia, Jia-lin Xing, Zheng Wang, Yuan Liu, Xing Hao, Chun-jing Jiang, Hong Wang, Ming Jia and Xiao-tong Hou

    Citation: Journal of Translational Medicine 2014 12:106

    Content type: Research

    Published on:

  49. Berberine (BBR), a natural plant extract, has been shown to improve lipid metabolism. However, its effects on PCSK9, a key factor involving in the lipid metabolism, have not yet been evaluated in vivo. The aim...

    Authors: Yan-Jun Jia, Rui-Xa Xu, Jing Sun, Yue Tang and Jian-Jun Li

    Citation: Journal of Translational Medicine 2014 12:103

    Content type: Research

    Published on:

  50. We tested the hypothesis that clopidogrel and cilostazol combination therapy could effectively attenuate systemic inflammatory reaction, facilitate proliferation of circulating endothelial progenitor cell (EPC...

    Authors: Jiunn-Jye Sheu, Pao-Yuan Lin, Pei-Hsun Sung, Yi-Ching Chen, Steve Leu, Yung-Lung Chen, Tzu-Hsien Tsai, Han-Tan Chai, Sarah Chua, Hsueh-Wen Chang, Sheng-Ying Chung, Chih-Hung Chen, Sheung-Fat Ko and Hon-Kan Yip

    Citation: Journal of Translational Medicine 2014 12:101

    Content type: Research

    Published on:

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