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Cancer Microenvironment

Section edited by Davide Bedognetti and Jessica Roelands

© © nopparit / Getty Images / iStock

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles


microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ

Research | Zhenming Jiang et al


Tumor microenvironment differences between primary tumor and brain metastases

Review | Bernardo Cacho-Díaz et al


Identification of key genes controlling breast cancer stem cell characteristics via stemness indices analysis

Research | Jianying Pei et al

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  1. We studied whether thymidylate synthase (TS) genotype has an independent prognostic/predictive impact on a European population of advanced non-small cell lung cancer (NSCLC) patients receiving pemetrexed.

    Authors: Estefanía Arévalo, Eduardo Castañón, Inés López, Josefa Salgado, Víctor Collado, Marta Santisteban, María Rodríguez-Ruiz, Patricia Martín, Leire Zubiri, Ana Patiño-García, Christian Rolfo and Ignacio Gil-Bazo
    Citation: Journal of Translational Medicine 2014 12:98
    Content type: Research Published on:

  3. Reliable prognostic markers based on biopsy specimens of colorectal cancer (CRC) are currently missing. We hypothesize that assessment of T-cell infiltration in biopsies of CRC may predict patient survival and...

    Authors: Viktor H Koelzer, Alessandro Lugli, Heather Dawson, Marion Hädrich, Martin D Berger, Markus Borner, Makhmudbek Mallaev, José A Galván, Jennifer Amsler, Beat Schnüriger, Inti Zlobec and Daniel Inderbitzin
    Citation: Journal of Translational Medicine 2014 12:81
    Content type: Research Published on:

  4. Transforming growth factor β (TGF-β) signaling functions as a suppressor or a promoter in tumor development, depending on the tumor stage and type. However, the role of TGF-β signaling in nonfunctioning pituit...

    Authors: Li Zhenye, Li Chuzhong, Wu Youtu, Lan Xiaolei, Cao Lei, Hong Lichuan, Wang Hongyun, Wu Yonggang, Wang Fei and Zhang Yazhuo
    Citation: Journal of Translational Medicine 2014 12:71
    Content type: Research Published on:

  5. The cross talk between the stroma and cancer cells plays a major role in phenotypic modulation. During peritoneal carcinomatosis ovarian cancer cells interact with mesenchymal stem cells (MSC) resulting in inc...

    Authors: Raphael Lis, Cyril Touboul, Najeeb M Halabi, Abishek Sainath Madduri, Denis Querleu, Jason Mezey, Joel A Malek, Karsten Suhre and Arash Rafii
    Citation: Journal of Translational Medicine 2014 12:59
    Content type: Research Published on:

  7. Recently, involvement of the chemokine/receptor system CCL20/CCR6 in colorectal cancer (CRC) progression was shown. Here, we analyzed the functional interaction of miRNA-518-5p (miR-518a-5p) with CCR6 and its ...

    Authors: Claudia Rubie, Bianca Kruse, Vilma Oliveira Frick, Kathrin Kölsch, Pirus Ghadjar, Mathias Wagner, Friedrich Grässer, Stefan Wagenpfeil and Mathias Glanemann
    Citation: Journal of Translational Medicine 2014 12:48
    Content type: Research Published on:

  8. Stents are recommended in patients with dysphagia caused by esophageal stricture, but an ideal stent does not currently exist. Thus, studies on new esophageal stents are necessary, and suitable animal models a...

    Authors: Jin Huang, Jinquan Shuang, Guanyin Xiong, Xiang Wang, Yin Zhang, Xiaowei Tang, Zhining Fan, Yingzhou Shen, Hanming Song and Zhi Liu
    Citation: Journal of Translational Medicine 2014 12:40
    Content type: Methodology Published on:

  9. miR-200b has been reported to be a tumor suppressor and a promising therapeutic target in cancer. miR-200b has been associated with epithelial-mesenchymal transition and chemo-resistance in cancer. The aim of ...

    Authors: Feng Ye, Hailin Tang, Qing Liu, Xinhua Xie, Minqing Wu, Xiaoping Liu, Bo Chen and Xiaoming Xie
    Citation: Journal of Translational Medicine 2014 12:17
    Content type: Research Published on:

  10. Estrogen receptor-alpha36 (ER-α36) is a new isoform of estrogen receptors without transcriptional activation domains of the classical ER-α(ER − α66). ER-α36 is mainly located in cytoplasm and plasma membrane. ...

    Authors: Yu Gu, Tianxiang Chen, Elena López, Weizhu Wu, Xiangdong Wang, Jiang Cao and Lisong Teng
    Citation: Journal of Translational Medicine 2014 12:16
    Content type: Review Published on:

  11. The interaction between tumor cells and inflammatory cells has not been systematically investigated in esophageal squamous cell carcinoma (ESCC). The main aims of the study were to investigate the clinical sig...

    Authors: Jianbo Wang, Yibin Jia, Nana Wang, Xiaomei Zhang, Bingxu Tan, Guangyu Zhang and Yufeng Cheng
    Citation: Journal of Translational Medicine 2014 12:7
    Content type: Research Published on:

  12. The role of exosomes in the pathogenesis and metastatic spread of cancer remains to be fully elucidated. Recent studies support the hypothesis that the release of exosomes from cells modifies local extracellul...

    Authors: Miharu Kobayashi, Carlos Salomon, Jorge Tapia, Sebastian E Illanes, Murray D Mitchell and Gregory E Rice
    Citation: Journal of Translational Medicine 2014 12:4
    Content type: Research Published on:

  14. XB130 has been reported to be expressed by various types of cells such as thyroid cancer and esophageal cancer cells, and it promotes the proliferation and invasion of thyroid cancer cells. Our previous study ...

    Authors: Min Shi, Dayong Zheng, Li Sun, Lin Wang, Li Lin, Yajun Wu, Minyu Zhou, Wenjun Liao, Yulin Liao, Qiang Zuo and Wangjun Liao
    Citation: Journal of Translational Medicine 2014 12:1
    Content type: Research Published on:

  15. CD34+ progenitor cells comprise both hematopoietic and endothelial progenitor cells. Recent studies suggest that circulating endothelial progenitor cells are recruited into the angiogenic vascular system of sever...

    Authors: Barbara Vizio, Fiorella Biasi, Tiziana Scirelli, Anna Novarino, Adriana Prati, Libero Ciuffreda, Giuseppe Montrucchio, Giuseppe Poli and Graziella Bellone
    Citation: Journal of Translational Medicine 2013 11:314
    Content type: Research Published on:

  16. Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human cancers and is known to inhibit Ras/Raf/MEK/ERK signaling. By suppressing the activation of the NF...

    Authors: Eva Karamitopoulou, Inti Zlobec, Beat Gloor, Agathi Kondi-Pafiti, Alessandro Lugli and Aurel Perren
    Citation: Journal of Translational Medicine 2013 11:311
    Content type: Research Published on:

  18. Conformal intensity-modulated radiation therapy (IMRT) involves irradiation of large volume of normal tissue with low and medium doses, biological relevance of which is not clear yet. Serum proteome features w...

    Authors: Piotr Widłak, Monika Pietrowska, Joanna Polańska, Tomasz Rutkowski, Karol Jelonek, Magdalena Kalinowska-Herok, Agnieszka Gdowicz-Kłosok, Andrzej Wygoda, Rafał Tarnawski and Krzysztof Składowski
    Citation: Journal of Translational Medicine 2013 11:299
    Content type: Research Published on:

  19. Bone marrow stromal cells (BMSCs) are multipotent cells that support angiogenesis, wound healing, and immunomodulation. In the hematopoietic niche, they nurture hematopoietic cells, leukemia, tumors and metast...

    Authors: Sara Civini, Ping Jin, Jiaqiang Ren, Marianna Sabatino, Luciano Castiello, Jianjian Jin, Huan Wang, Yuanlong Zhao, Francesco Marincola and David Stroncek
    Citation: Journal of Translational Medicine 2013 11:298
    Content type: Research Published on:

  20. Obesity is a well established risk factor of colorectal cancer (CRC), but how body size influences risk of colorectal cancer defined by key molecular alterations remains unclear. In this study, we investigated...

    Authors: Jenny Brändstedt, Sakarias Wangefjord, Signe Borgquist, Björn Nodin, Jakob Eberhard, Jonas Manjer and Karin Jirström
    Citation: Journal of Translational Medicine 2013 11:293
    Content type: Research Published on:

  21. Cadherin 12 (CDH12), which encodes a type II classical cadherin from the cadherin superfamily, may mediate calcium-dependent cell adhesion. It has been demonstrated that CDH12 could play an important role in t...

    Authors: Jingkun Zhao, Pu Li, Hao Feng, Puxiongzhi Wang, Yaping Zong, Junjun Ma, Zhuo Zhang, Xuehua Chen, Minhua Zheng, Zhenggang Zhu and Aiguo Lu
    Citation: Journal of Translational Medicine 2013 11:288
    Content type: Research Published on:

  22. In recent years an increasing number of publications have emphasized the growing importance of hydrogen ion dynamics in modern cancer research, from etiopathogenesis and treatment. A proton [H+]-related mechanism...

    Authors: Salvador Harguindey, Jose Luis Arranz, Julian David Polo Orozco, Cyril Rauch, Stefano Fais, Rosa Angela Cardone and Stephan J Reshkin
    Citation: Journal of Translational Medicine 2013 11:282
    Content type: Review Published on:

  23. Residual tumor progression after insufficient radiofrequency ablation (RFA) has been recently reported. However, whether epithelial-mesenchymal transition (EMT), which is a key process that drives cancer metas...

    Authors: Shuying Dong, Jian Kong, Fandong Kong, Jinge Kong, Jun Gao, Shan Ke, Shaohong Wang, Xuemei Ding, Wenbing Sun and Lemin Zheng
    Citation: Journal of Translational Medicine 2013 11:273
    Content type: Research Published on:

  24. Transglutaminase-4 (TGase-4), also known as the Prostate Transglutaminase, is an enzyme found to be expressed predominately in the prostate gland. The protein has been recently reported to influence the migrat...

    Authors: Wen G Jiang, Lin Ye, Andrew J Sanders, Fiona Ruge, Howard G Kynaston, Richard J Ablin and Malcolm D Mason
    Citation: Journal of Translational Medicine 2013 11:269
    Content type: Research Published on:

  25. Dinaciclib, a small-molecule, cyclin-dependent kinase inhibitor, inhibits cell cycle progression and proliferation in various tumor cell lines in vitro. We conducted an open-label, dose-escalation study to det...

    Authors: John J Nemunaitis, Karen A Small, Paul Kirschmeier, Da Zhang, Yali Zhu, Ying-Ming Jou, Paul Statkevich, Siu-Long Yao and Rajat Bannerji
    Citation: Journal of Translational Medicine 2013 11:259
    Content type: Research Published on:

  26. Up to 40% of patients initially diagnosed with clinically-confined renal cell carcinoma (RCC) and who undergo curative surgery will nevertheless relapse with metastatic disease (mRCC) associated with poor long...

    Authors: Lee Campbell, Ghaith Al-Jayyoussi, Robert Gutteridge, Nigel Gumbleton, Rosie Griffiths, Simon Gumbleton, Mathew W Smith, David FR Griffiths and Mark Gumbleton
    Citation: Journal of Translational Medicine 2013 11:255
    Content type: Research Published on:

  27. The chemokine CXCL12 and its receptor CXCR4 play a major role in tumor invasion, proliferation and metastasis in different malignant diseases, including esophageal carcinoma, amongst others. CXCR7 was recently...

    Authors: Michael Tachezy, Hilke Zander, Florian Gebauer, Katharina von Loga, Klaus Pantel, Jakob R Izbicki and Maximilian Bockhorn
    Citation: Journal of Translational Medicine 2013 11:238
    Content type: Research Published on:

  28. Oct4 is a major transcription factor related to stem cell self-renewal and differentiation. To fulfill its functions, it must be able to enter the nucleus and remain there to affect transcription. KPNA2, a mem...

    Authors: Xiao-Lei Li, Lan-Ling Jia, Mu-Mu Shi, Xin Li, Zhong-Hua Li, Hui-Feng Li, En-Hua Wang and Xin-Shan Jia
    Citation: Journal of Translational Medicine 2013 11:232
    Content type: Research Published on:

  29. Special AT rich sequence binding protein 1 (SATB1) plays a crucial role in the biology of various types of human cancer. However, the role of SATB1 in human nasopharyngeal carcinoma (NPC) remains unknown. In t...

    Authors: Zhihua Shen, Yumei Zeng, Junli Guo, Yanxia Wu, Xiaofan Jiang, Ranran Ding, Changli Wu, Rujia Li, Botao Luo, Chao Zeng, Hanguo Jiang and Wei Jie
    Citation: Journal of Translational Medicine 2013 11:217
    Content type: Research Published on:

  30. Recent studies have indicated that the expression of endothelin A receptor (ETAR) and chemokine receptor 4 (CXCR4) could be used as an indicator of the metastatic potential of nasopharyngeal carcinoma (NPC). T...

    Authors: Dong-Hua Luo, Qiu-Yan Chen, Huai Liu, Li-Hua Xu, Hui-Zhong Zhang, Lu Zhang, Lin-Quan Tang, Hao-Yuan Mo, Pei-Yu Huang, Xiang Guo and Hai-Qiang Mai
    Citation: Journal of Translational Medicine 2013 11:203
    Content type: Research Published on:

  31. Chronic inflammation has been recognized to foster tumour development. Whether chemotherapy can be used to neutralize chronic inflammation is unclear.

    Authors: Andreas Carus, Howard Gurney, Val Gebski, Paul Harnett, Rina Hui, Richard Kefford, Nicholas Wilcken, Morten Ladekarl, Hans von der Maase and Frede Donskov
    Citation: Journal of Translational Medicine 2013 11:189
    Content type: Research Published on:

  32. Array-CGH represents a comprehensive tool to discover genomic disease alterations that could potentially be applied to body fluids. In this report, we aimed at applying array-CGH to urinary samples to characte...

    Authors: Virginia López, Pilar González-Peramato, Javier Suela, Alvaro Serrano, Ferrán Algaba, Juan C Cigudosa, August Vidal, Joaquim Bellmunt, Oscar Heredero and Marta Sánchez-Carbayo
    Citation: Journal of Translational Medicine 2013 11:182
    Content type: Research Published on:

  33. Estrogens were recently demonstrated to be synthesized in non-small cell lung carcinomas (NSCLCs) via aromatase activity and aromatase inhibitor (AI) did suppressed estrogen receptor (ER) positive NSCLC growth. H...

    Authors: Mohit K Verma, Yasuhiro Miki, Keiko Abe, Takashi Suzuki, Hiromichi Niikawa, Satoshi Suzuki, Takashi Kondo and Hironobu Sasano
    Citation: Journal of Translational Medicine 2013 11:167
    Content type: Research Published on:

  34. The epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) play pivotal roles in metastasis of epithelial cancers. The distinction between them has shed new light on the mole...

    Authors: Songming Ding, Wu Zhang, Zhiyuan Xu, Chunyang Xing, Haiyang Xie, Haijun Guo, Kanjie Chen, Penghong Song, Yu Gu, Fengqiang Xiao, Lin Zhou and Shusen Zheng
    Citation: Journal of Translational Medicine 2013 11:164
    Content type: Research Published on:

  35. Given the complexity of tumor microenvironment, no single marker from cancer cells could adequately predict the clinical outcomes of gastric cancer (GC). The objective of this study was to evaluate the prognos...

    Authors: Chun-Wei Peng, Lin-Wei Wang, Min Fang, Gui-Fang Yang, Yan Li and Dai-Wen Pang
    Citation: Journal of Translational Medicine 2013 11:153
    Content type: Research Published on:

  36. Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic know...

    Authors: Vincent Lavoué, Aurélie Thédrez, Jean Levêque, Fabrice Foucher, Sébastien Henno, Vincent Jauffret, Marc-Antoine Belaud-Rotureau, Veronique Catros and Florian Cabillic
    Citation: Journal of Translational Medicine 2013 11:147
    Content type: Review Published on:

  37. Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems.

    Authors: Maria Libera Ascierto, Michael O Idowu, Yingdong Zhao, Hanif Khalak, Kyle K Payne, Xiang-Yang Wang, Catherine I Dumur, Davide Bedognetti, Sara Tomei, Paolo A Ascierto, Anil Shanker, Harry D Bear, Ena Wang, Francesco M Marincola, Andrea De Maria and Masoud H Manjili
    Citation: Journal of Translational Medicine 2013 11:145
    Content type: Research Published on:

  38. Human papillomavirus type 16 (HPV 16) E2 protein is a multifunctional DNA-binding protein. HPV 16 E2 regulates many biological responses, including DNA replication, gene expression, and apoptosis. The purpose ...

    Authors: Ling-juan Gao, Ping-qing Gu, Wei Zhao, Wen-yan Ding, Xue-qing Zhao, Shu-yu Guo and Tian-ying Zhong
    Citation: Journal of Translational Medicine 2013 11:118
    Content type: Research Published on:

  39. Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as the global chromatin organizer to regulate chromatin structure and gene expression gene expression. SATB1 has been shown...

    Authors: Lijun Mao, Chunhua Yang, Junqi Wang, Wang Li, Rumin Wen, Jiacun Chen and Junnian Zheng
    Citation: Journal of Translational Medicine 2013 11:111
    Content type: Research Published on:

  40. Studies of primary patient tumor xenografts grown in immunodeficient mice have shown that these tumors histologically and genetically closely resemble the original tumors. These patient xenograft models are be...

    Authors: Bonnie L Hylander, Natalie Punt, Haikuo Tang, Joanna Hillman, Mary Vaughan, Wiam Bshara, Rose Pitoniak and Elizabeth A Repasky
    Citation: Journal of Translational Medicine 2013 11:110
    Content type: Research Published on:

  41. Interleukin (IL)-6 (mainly of tumor origin) activates glutathione (GSH) release from hepatocytes and its interorgan transport to B16-F10 melanoma metastatic foci. We studied if this capacity to overproduce IL-...

    Authors: Soraya L Valles, María Benlloch, María L Rodriguez, Salvador Mena, José A Pellicer, Miguel Asensi, Elena Obrador and José M Estrela
    Citation: Journal of Translational Medicine 2013 11:72
    Content type: Research Published on:

  42. T-cell infiltration in primary colon tumors is associated with improved patient survival. Preliminary data supports a similar association in colorectal liver metastases (CRLM), and we previously identified inc...

    Authors: Jian Zhong Qin, Vivek Upadhyay, Bellur Prabhakar and Ajay V Maker
    Citation: Journal of Translational Medicine 2013 11:70
    Content type: Research Published on:

  43. Our previous study showed that SLC22A18 downregulation and promoter methylation were associated with the development and progression of glioma and the elevated expression of SLC22A18 was found to increase the ...

    Authors: Sheng-Hua Chu, Yan-Bin Ma, Dong-Fu Feng, Zhi-Qiang Li and Pu-Cha Jiang
    Citation: Journal of Translational Medicine 2013 11:69
    Content type: Research Published on:

  44. Tumor-derived cytokines and their receptors usually take important roles in the disease progression and prognosis of cancer patients. In this survey, we aimed to detect the expression levels of MIF and CXCR4 i...

    Authors: Lin Zhang, Shu-Biao Ye, Gang Ma, Xiao-Feng Tang, Shi-Ping Chen, Jia He, Wan-Li Liu, Dan Xie, Yi-Xin Zeng and Jiang Li
    Citation: Journal of Translational Medicine 2013 11:60
    Content type: Research Published on:

  45. Protein tyrosine kinase 6 (PTK6), also known as breast tumor kinase (Brk), was a nonreceptor tyrosine kinase containing SH3, SH2, and tyrosine kinase catalytic domains. The deregulated expression of PTK6 was o...

    Authors: Xue-Kui Liu, Xin-Rui Zhang, Qian Zhong, Man-Zhi Li, Zhi-Min Liu, Zhi-Rui Lin, Di Wu and Mu-Sheng Zeng
    Citation: Journal of Translational Medicine 2013 11:59
    Content type: Research Published on:

  46. According to the Lauren classification, gastric adenocarcinomas are divided into diffuse and intestinal types. The causative attribution explaining the dismal prognosis of diffuse-type remains unknown.

    Authors: Miao-zhen Qiu, Mu-yan Cai, Dong-sheng Zhang, Zhi-qiang Wang, De-shen Wang, Yu-hong Li and Rui-hua Xu
    Citation: Journal of Translational Medicine 2013 11:58
    Content type: Research Published on:

  47. Wnt signaling in the colon cancer tumor microenvironment (TME) may affect cancer biologic properties including invasion and metastatic dissemination. Prior reports have suggested that the expression of select ...

    Authors: Kestutis Planutis, Marina Planutiene, Anthony V Nguyen, Mary Pat Moyer and Randall F Holcombe
    Citation: Journal of Translational Medicine 2013 11:50
    Content type: Research Published on:

  48. Cryoablation is one of the local therapies for hepatocellular carcinoma (HCC), but its safety and effect has not been studied in patients with Child class A or B and Barcelona Clinic Liver Cancer (BCLC) stage ...

    Authors: Yong-Ping Yang, Jian-Hui Qu, Xiu-Juan Chang, Yin-Ying Lu, Wen-Lin Bai, Zheng Dong, Hong Wang, Lin-Jing An, Zhong-Xian Xu, Chun-Ping Wang, Zhen Zeng and Ke-Qin Hu
    Citation: Journal of Translational Medicine 2013 11:41
    Content type: Research Published on:

  49. Myeloid-derived suppressor cells (MDSCs) are one of the major components of the immune-suppressive network, play key roles in tumor progression and limit therapeutic responses. Recently, we reported that tumor...

    Authors: Archana Thakur, Dana Schalk, Elyse Tomaszewski, Sri Vidya Kondadasula, Hiroshi Yano, Fazlul H Sarkar and Lawrence G Lum
    Citation: Journal of Translational Medicine 2013 11:35
    Content type: Research Published on:

  50. Colorectal carcinomas spread easily to nearby tissues around the colon or rectum, and display strong potential for invasion and metastasis. CSE1L, the chromosome segregation 1-like protein, is implicated in ca...

    Authors: Cheng-Jeng Tai, Tzu-Cheng Su, Ming-Chung Jiang, Hung-Chang Chen, Shing-Chuan Shen, Woan-Ruoh Lee, Ching-Fong Liao, Ying-Chun Chen, Shu-Hui Lin, Li-Tzu Li, Ko-Hung Shen, Chung-Min Yeh, Kun-Tu Yeh, Ching-Hsiao Lee, Hsin-Yi Shih and Chun-Chao Chang
    Citation: Journal of Translational Medicine 2013 11:29
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:315

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