Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z: The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010, 327 (5973): 1650-1653. 10.1126/science.1186624.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hoang VT, Zepeda-Moreno A, Ho AD: Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance. Biotechnol J. 2012, 7 (6): 779-788. 10.1002/biot.201100350.
Article
CAS
PubMed
Google Scholar
Ashton JM, Balys M, Neering SJ, Hassane DC, Cowley G, Root DE: Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells. Cell Stem Cell. 2012, 11 (3): 359-372. 10.1016/j.stem.2012.05.024.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ferretti E, Cocco C, Airoldi I, Pistoia V: Targeting acute myeloid leukemia cells with cytokines. J Leukoc Biol. 2012, 92 (3): 567-575. 10.1189/jlb.0112036.
Article
CAS
PubMed
Google Scholar
Jordan CT, Upchurch D, Szilvassy SJ, Guzman ML, Howard DS, Pettigrew AL: The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia: official journal of the Leukemia Society of America. Leukemia. 2000, 14 (10): 1777-1784. 10.1038/sj.leu.2401903.
Article
CAS
PubMed
Google Scholar
van Rhenen A, Moshaver B, Kelder A, Feller N, Nieuwint AW, Zweegman S: Aberrant marker expression patterns on the CD34+CD38- stem cell compartment in acute myeloid leukemia allows to distinguish the malignant from the normal stem cell compartment both at diagnosis and in remission. Leukemia. 2007, 21 (8): 1700-1707. 10.1038/sj.leu.2404754.
Article
CAS
PubMed
Google Scholar
Hosen N, Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M: CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Proc Natl Acad Sci USA. 2007, 104 (26): 11008-11013. 10.1073/pnas.0704271104.
Article
PubMed Central
CAS
PubMed
Google Scholar
Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD: CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 2009, 138 (2): 286-299. 10.1016/j.cell.2009.05.045.
Article
PubMed Central
CAS
PubMed
Google Scholar
Jaiswal S, Jamieson CH, Pang WW, Park CY, Chao MP, Majeti R: CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009, 138 (2): 271-285. 10.1016/j.cell.2009.05.046.
Article
PubMed Central
CAS
PubMed
Google Scholar
Colmone A, Amorim M, Pontier AL, Wang S, Jablonski E, Sipkins DA: Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science. 2008, 322 (5909): 1861-1865. 10.1126/science.1164390.
Article
CAS
PubMed
Google Scholar
Konopleva MY, Jordan CT: Leukemia stem cells and microenvironment: biology and therapeutic targeting. J Clin Oncol. 2011, 29 (5): 591-599. 10.1200/JCO.2010.31.0904.
Article
PubMed
Google Scholar
Kojima K, McQueen T, Chen Y, Jacamo R, Konopleva M, Shinojima N: p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1alpha-mediated down-regulation of CXCL12. Blood. 2011, 118 (16): 4431-4439. 10.1182/blood-2011-02-334136.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling X, Frolova O: Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood. 2009, 113 (24): 6215-6224. 10.1182/blood-2008-05-158311.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tabe Y, Jin L, Iwabuchi K, Wang RY, Ichikawa N, Miida T: Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts. Leukemia: official journal of the Leukemia Society of America. Leukemia. 2012, 26 (5): 883-892. 10.1038/leu.2011.291.
Article
CAS
PubMed
Google Scholar
Sansonetti A, Bourcier S, Durand L, Chomienne C, Smadja-Joffe F, Robert-Lezenes J: CD44 activation enhances acute monoblastic leukemia cell survival via Mcl-1 upregulation. Leuk Res. 2012, 36 (3): 358-362. 10.1016/j.leukres.2011.09.022.
Article
CAS
PubMed
Google Scholar
Becker PS: Dependence of acute myeloid leukemia on adhesion within the bone marrow microenvironment. Scientific World Journal. 2012, 2012: 856467-
Article
PubMed Central
PubMed
Google Scholar
Nagahisa H, Nagata Y, Ohnuki T, Osada M, Nagasawa T, Abe T: Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation. Blood. 1996, 87 (4): 1309-1316.
CAS
PubMed
Google Scholar
Bianco P, Robey PG, Simmons PJ: Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell. 2008, 2 (4): 313-319. 10.1016/j.stem.2008.03.002.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA: Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010, 466 (7308): 829-834. 10.1038/nature09262.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nagasawa T, Omatsu Y, Sugiyama T: Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells. Trends Immunol. 2011, 32 (7): 315-320. 10.1016/j.it.2011.03.009.
Article
CAS
PubMed
Google Scholar
Westerterp M, Gourion-Arsiquaud S, Murphy AJ, Shih A, Cremers S, Levine RL: Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell. 2012, 11 (2): 195-206. 10.1016/j.stem.2012.04.024.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bianco P: Minireview: The stem cell next door: skeletal and hematopoietic stem cell “niches” in bone. Endocrinology. 2011, 152 (8): 2957-2962. 10.1210/en.2011-0217.
Article
CAS
PubMed
Google Scholar
Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006, 8 (4): 315-317. 10.1080/14653240600855905.
Article
CAS
PubMed
Google Scholar
Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC: Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy. 2005, 7 (5): 393-395. 10.1080/14653240500319234.
Article
CAS
PubMed
Google Scholar
Aggarwal S, Pittenger MF: Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005, 105 (4): 1815-1822. 10.1182/blood-2004-04-1559.
Article
CAS
PubMed
Google Scholar
Caplan AI, Dennis JE: Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006, 98 (5): 1076-1084. 10.1002/jcb.20886.
Article
CAS
PubMed
Google Scholar
Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI: Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell. 2008, 2 (2): 141-150. 10.1016/j.stem.2007.11.014.
Article
CAS
PubMed
Google Scholar
Horwitz EM, Dominici M: How do mesenchymal stromal cells exert their therapeutic benefit?. Cytotherapy. 2008, 10 (8): 771-774. 10.1080/14653240802618085.
Article
CAS
PubMed
Google Scholar
Ren J, Jin P, Sabatino M, Balakumaran A, Feng J, Kuznetsov SA: Global transcriptome analysis of human bone marrow stromal cells (BMSC) reveals proliferative, mobile and interactive cells that produce abundant extracellular matrix proteins, some of which may affect BMSC potency. Cytotherapy. 2011, 13 (6): 661-674. 10.3109/14653249.2010.548379.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mercier FE, Ragu C, Scadden DT: The bone marrow at the crossroads of blood and immunity. Nature reviews. Immunology. 2012, 12 (1): 49-60.
CAS
Google Scholar
Zhang W, Trachootham D, Liu J, Chen G, Pelicano H, Garcia-Prieto C: Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. Nat Cell Biol. 2012, 14 (3): 276-286. 10.1038/ncb2432.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yusuf RZ, Wang YH, Scadden DT: The secrets of the bone marrow niche: Metabolic priming for AML. Nat Med. 2012, 18 (6): 865-867. 10.1038/nm.2831.
Article
PubMed Central
CAS
PubMed
Google Scholar
Shain KH, Yarde DN, Meads MB, Huang M, Jove R, Hazlehurst LA: Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation. Cancer Res. 2009, 69 (3): 1009-1015. 10.1158/0008-5472.CAN-08-2419.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bergfeld SA, DeClerck YA: Bone marrow-derived mesenchymal stem cells and the tumor microenvironment. Cancer Metastasis Rev. 2010, 29 (2): 249-261. 10.1007/s10555-010-9222-7.
Article
PubMed
Google Scholar
Anderson KC, Carrasco RD: Pathogenesis of myeloma. Annu Rev Pathol. 2011, 6: 249-274. 10.1146/annurev-pathol-011110-130249.
Article
CAS
PubMed
Google Scholar
Sabatino M, Ren J, David-Ocampo V, England L, McGann M, Tran M: The establishment of a bank of stored clinical bone marrow stromal cell products. J Transl Med. 2012, 10: 23-10.1186/1479-5876-10-23.
Article
PubMed Central
CAS
PubMed
Google Scholar
Garrido SM, Appelbaum FR, Willman CL, Banker DE: Acute myeloid leukemia cells are protected from spontaneous and drug-induced apoptosis by direct contact with a human bone marrow stromal cell line (HS-5). Exp Hematol. 2001, 29 (4): 448-457. 10.1016/S0301-472X(01)00612-9.
Article
CAS
PubMed
Google Scholar
Weisberg E, Liu Q, Nelson E, Kung AL, Christie AL, Bronson R: Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors. Leukemia. 2012, 26 (10): 2233-2244. 10.1038/leu.2012.96.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tabe Y, Jin L, Tsutsumi-Ishii Y, Xu Y, McQueen T, Priebe W: Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Cancer Res. 2007, 67 (2): 684-694. 10.1158/0008-5472.CAN-06-3166.
Article
CAS
PubMed
Google Scholar
Konopleva M, Konoplev S, Hu W, Zaritskey AY, Afanasiev BV, Andreeff M: Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia. 2002, 16 (9): 1713-1724. 10.1038/sj.leu.2402608.
Article
CAS
PubMed
Google Scholar
Nefedova Y, Landowski TH, Dalton WS: Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms. Leukemia. 2003, 17 (6): 1175-1182. 10.1038/sj.leu.2402924.
Article
CAS
PubMed
Google Scholar
Qian Y, Kang Z, Liu C, Li X: IL-17 signaling in host defense and inflammatory diseases. Cell Mol Immunol. 2010, 7 (5): 328-333. 10.1038/cmi.2010.27.
Article
PubMed Central
CAS
PubMed
Google Scholar
Parmar A, Marz S, Rushton S, Holzwarth C, Lind K, Kayser S: Stromal niche cells protect early leukemic FLT3-ITD + progenitor cells against first-generation FLT3 tyrosine kinase inhibitors. Cancer Res. 2011, 71 (13): 4696-4706. 10.1158/0008-5472.CAN-10-4136.
Article
CAS
PubMed
Google Scholar
Reikvam H, Mosevoll KA, Melve GK, Gunther CC, Sjo M, Bentsen PT: The pretransplantation serum cytokine profile in allogeneic stem cell recipients differs from healthy individuals, and various profiles are associated with different risks of posttransplantation complications. Biol Blood Marrow Transplant. 2012, 18 (2): 190-199. 10.1016/j.bbmt.2011.10.007.
Article
CAS
PubMed
Google Scholar
Kornblau SM, McCue D, Singh N, Chen W, Estrov Z, Coombes KR: Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia. Blood. 2010, 116 (20): 4251-4261. 10.1182/blood-2010-01-262071.
Article
PubMed Central
CAS
PubMed
Google Scholar
Burgess M, Cheung C, Chambers L, Ravindranath K, Minhas G, Knop L: CCL2 and CXCL2 enhance survival of primary chronic lymphocytic leukemia cells in vitro. Leuk Lymphoma. 2012, 53 (10): 1988-1998. 10.3109/10428194.2012.672735.
Article
CAS
PubMed
Google Scholar
Cashman JD, Eaves CJ, Sarris AH, Eaves AC: MCP-1, not MIP-1alpha, is the endogenous chemokine that cooperates with TGF-beta to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures. Blood. 1998, 92 (7): 2338-2344.
CAS
PubMed
Google Scholar
Broxmeyer HE, Cooper S, Cacalano G, Hague NL, Bailish E, Moore MW: Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue. J Exp Med. 1996, 184 (5): 1825-1832. 10.1084/jem.184.5.1825.
Article
CAS
PubMed
Google Scholar
Schwartz GN, Kammula U, Warren MK, Park MK, Yan XY, Marincola FM: Thrombopoietin and chemokine mRNA expression in patient post-chemotherapy and in vitro cytokine-treated marrow stromal cell layers. Stem Cells. 2000, 18( (5): 331-342.
Article
Google Scholar
Ren J, Stroncek DF, Zhao Y, Jin P, Castiello L, Civini S: Intra-subject variability in human bone marrow stromal cell (BMSC) replicative senescence: Molecular changes associated with BMSC senescence. Stem Cell Res. 2013, 11 (3): 1060-1073. 10.1016/j.scr.2013.07.005.
Article
CAS
PubMed
Google Scholar
Zhukareva V, Obrocka M, Houle JD, Fischer I, Neuhuber B: Secretion profile of human bone marrow stromal cells: donor variability and response to inflammatory stimuli. Cytokine. 2010, 50 (3): 317-321. 10.1016/j.cyto.2010.01.004.
Article
CAS
PubMed
Google Scholar
Wei J, Wunderlich M, Fox C, Alvarez S, Cigudosa JC, Wilhelm JS: Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell. 2008, 13 (6): 483-495. 10.1016/j.ccr.2008.04.020.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hole PS, Darley RL, Tonks A: Do reactive oxygen species play a role in myeloid leukemias?. Blood. 2011, 117 (22): 5816-5826. 10.1182/blood-2011-01-326025.
Article
CAS
PubMed
Google Scholar