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Cancer Microenvironment

Section edited by Davide Bedognetti and Jessica Roelands

© © nopparit / Getty Images / iStock

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles

microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ

Research | Zhenming Jiang et al

Tumor microenvironment differences between primary tumor and brain metastases

Review | Bernardo Cacho-Díaz et al

Identification of key genes controlling breast cancer stem cell characteristics via stemness indices analysis

Research | Jianying Pei et al

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  1. Cisplatin is the main chemotherapeutic drug for the treatment of cervical cancers, however resistance to cisplatin is increasingly common and therefore has limited the efficacy and use of this drug in the clin...

    Authors: Gina Leisching, Benjamin Loos, Matthys Botha and Anna-Mart Engelbrecht
    Citation: Journal of Translational Medicine 2015 13:328
  2. Malignant pleural effusion resulting mainly from pleural metastases of lung adenocarcinoma has clinical relevance, being a sign of poor prognosis and low life expectancy. Experimental models can mimic the hum...

    Authors: Milena Marques Pagliarelli Acencio, Juliana Puka, Evaldo Marchi, Leila Antonangelo, Ricardo Mingarini Terra, Francisco Suso Vargas, Vera Luiza Capelozzi and Lisete Ribeiro Teixeira
    Citation: Journal of Translational Medicine 2015 13:302
  3. An increasing number of studies have demonstrated that deregulation of microRNAs (miRNAs) was a common event in tumor tissues and miRNAs would be treated as ideal tumor biomarkers or therapeutic targets. miR-1...

    Authors: Jian Wu, Alin Ji, Xiao Wang, Yi Zhu, Yasai Yu, Yiwei Lin, Yunfu Liu, Shiqi Li, Zhen Liang, Xin Xu, Xiangyi Zheng and Liping Xie
    Citation: Journal of Translational Medicine 2015 13:289
  4. Hepatocyte growth factor (HGF) is a cytokine that has a profound effect on cancer cells by stimulating migration and invasion and acting as an angiogenic factor. In lung cancer, the factor also plays a pivota...

    Authors: Wen G. Jiang, Lin Ye, Fiona Ruge, Sioned Owen, Tracey Martin, Ping-Hui Sun, Andrew J. Sanders, Jane Lane, Lucy Satherley, Hoi P. Weeks, Yong Gao, Cong Wei, Yiling Wu and Malcolm D. Mason
    Citation: Journal of Translational Medicine 2015 13:280

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:20

  5. Various microRNAs (miRNAs) negatively modulate genes that are involved in cellular proliferation, differentiation, invasion, and apoptosis. In many types of cancer, the expression profiles of these miRNAs are ...

    Authors: MingHua Li, LinLi Tian, Hui Ren, XiaoXue Chen, Yu Wang, JingChun Ge, ShuLiang Wu, YaNan Sun, Ming Liu and Hui Xiao
    Citation: Journal of Translational Medicine 2015 13:271
  6. Liver metastases appear in 20–30% of patients diagnosed with non-small cell lung cancer (NSCLC) and represent a poor prognosis feature of NSCLC and a possibly more treatment-resistant condition. Potential clin...

    Authors: Eduardo Castañón, Christian Rolfo, David Viñal, Inés López, Juan P Fusco, Marta Santisteban, Patricia Martin, Leire Zubiri, José I Echeveste and Ignacio Gil-Bazo
    Citation: Journal of Translational Medicine 2015 13:257
  7. Radioresistance is a challenge in the treatment of patients with colorectal cancer (CRC). Individuals display different therapeutic responses to preoperative radiotherapy, and the need of targeted therapies is...

    Authors: Lin Zheng, Yuqin Zhang, Yan Liu, Min Zhou, Yanxia Lu, Li Yuan, Chao Zhang, Min Hong, Shuang Wang and Xuenong Li
    Citation: Journal of Translational Medicine 2015 13:252
  8. Carcinoma associated fibroblasts (CAFs), an important component of tumor microenvironment, are capable of enhancing tumor cells invasion and migration through initiation of epithelial–mesenchymal transition (E...

    Authors: Songming Ding, Guoliang Chen, Wu Zhang, Chunyang Xing, Xiao Xu, Haiyang Xie, Aili Lu, Kangjie Chen, Haijun Guo, Zhigang Ren, Shusen Zheng and Lin Zhou
    Citation: Journal of Translational Medicine 2015 13:237
  9. We and others have extensively investigated the role of PARP-1 in cell growth and demise in response to pathophysiological cues. Most of the clinical trials on PARP inhibitors are targeting primarily estrogen ...

    Authors: Hogyoung Kim, Abdelmetalab Tarhuni, Zakaria Y Abd Elmageed and A Hamid Boulares
    Citation: Journal of Translational Medicine 2015 13:233
  10. In this era of precision medicine, the deep and comprehensive characterization of tumor phenotypes will lead to therapeutic strategies beyond classical factors such as primary sites or anatomical staging. Rece...

    Authors: Anna Halama, Bella S Guerrouahen, Jennifer Pasquier, Ilhem Diboun, Edward D Karoly, Karsten Suhre and Arash Rafii
    Citation: Journal of Translational Medicine 2015 13:223
  11. Cancer-associated fibroblast (CAF) is the most studied element of the tumor microenvironment, although no relationship has been identified between expression of their related proteins and the metastasis site. ...

    Authors: Hye Min Kim, Woo Hee Jung and Ja Seung Koo
    Citation: Journal of Translational Medicine 2015 13:222
  12. Oncolytic virotherapy is a novel approach for the treatment of glioblastoma multiforme (GBM) which is still a fatal disease. Pathologic features of GBM are characterized by the infiltration with microglia/macr...

    Authors: Christina Kober, Susanne Rohn, Stephanie Weibel, Ulrike Geissinger, Nanhai G Chen and Aladar A Szalay
    Citation: Journal of Translational Medicine 2015 13:216
  13. Since the mid-1950’s, melanoma incidence has been rising steadily in industrialized Caucasian populations, thereby pointing to the pivotal involvement of environmental factors in melanomagenesis. Recent eviden...

    Authors: Bodo C Melnik
    Citation: Journal of Translational Medicine 2015 13:202
  14. Oral tongue squamous cell carcinoma (OTSCC) is still associated with a poor prognosis due to local recurrence and metastasis. Cancer-associated fibroblasts (CAFs) play an important role in the complex processe...

    Authors: Huan Li, Ji Zhang, Shu-Wei Chen, Lu-lu Liu, Lei Li, Fan Gao, Shi-Min Zhuang, Li-ping Wang, Yan Li and Ming Song
    Citation: Journal of Translational Medicine 2015 13:198
  15. Adrenomedullin (AM) is a regulatory peptide whose involvement in tumour progression is becoming more relevant with recent studies. AM is produced and secreted by the tumour cells but also by numerous stromal c...

    Authors: Ignacio M Larráyoz, Sonia Martínez-Herrero, Josune García-Sanmartín, Laura Ochoa-Callejero and Alfredo Martínez
    Citation: Journal of Translational Medicine 2014 12:339
  16. Ovarian cancer is the deadliest gynaecologic malignancy. Despite progresses in chemotherapy and ultra-radical surgeries, this locally metastatic disease presents a high rate of local recurrence advocating for ...

    Authors: Cyril Touboul, Fabien Vidal, Jennifer Pasquier, Raphael Lis and Arash Rafii
    Citation: Journal of Translational Medicine 2014 12:271
  17. We previously confirmed that propofol directly inhibited the viability, proliferation, and invasiveness of hepatocellular carcinoma cells in vitro. In this study, we investigated the mechanism underlying the anti...

    Authors: Jian Zhang, Wei-feng Shan, Te-te Jin, Guo-qing Wu, Xiao-xing Xiong, Hai-yan Jin and Sheng-mei Zhu
    Citation: Journal of Translational Medicine 2014 12:279
  18. Human papillomavirus type-16 (HPV-16) E2 protein acts as a transcriptional modulator and plays a key role in regulating many biological responses. The purpose of this study was to investigate the relationship ...

    Authors: Zheng-lin Chen, Ya-juan Su, Hui-lin Zhang, Ping-qing Gu and Ling-juan Gao
    Citation: Journal of Translational Medicine 2014 12:286
  19. Aberrant AKT activation contributes to gastric cancer cell survival and chemotherapy resistance, however its regulation is poorly understood. microRNAs have been established to be important regulators in gastr...

    Authors: Wei Kang, Joanna HM Tong, Raymond WM Lung, Yujuan Dong, Weiqin Yang, Yi Pan, Kin Mang Lau, Jun Yu, Alfred SL Cheng and Ka Fai To
    Citation: Journal of Translational Medicine 2014 12:281
  20. Although several studies suggest that stromal fibroblasts mediate treatment resistance in several cancer types, little is known about how tumor-associated astrocytes modulate the treatment response in brain tu...

    Authors: Ning Yang, Tao Yan, Huaiyang Zhu, Xiao Liang, Lina Leiss, Per Øystein Sakariassen, Kai Ove Skaftnesmo, Bin Huang, Daniela Elena Costea, Per Øyvind Enger, Xingang Li and Jian Wang
    Citation: Journal of Translational Medicine 2014 12:278
  21. Galectin-3, a member of the beta-galactoside-binding lectin family, is a multifunctional protein with various biological functions, including the proliferation and differentiation of tumor cells, angiogenesis,...

    Authors: Shan-Shan Jiang, De-Sheng Weng, Qi-Jing Wang, Ke Pan, Yao-Jun Zhang, Yong-Qiang Li, Jian-Jun Li, Jing-Jing Zhao, Jia He, Lin Lv, Qiu-Zhong Pan and Jian-Chuan Xia
    Citation: Journal of Translational Medicine 2014 12:273
  22. The omentum is one of the initial sites for peritoneal metastasis because it possesses milky spots that provide a microenvironment for cancer cells to readily migrate and grow into micrometastases. This study ...

    Authors: Liang Cao, Xiang Hu, Jian Zhang, Gang Huang and Yi Zhang
    Citation: Journal of Translational Medicine 2014 12:267
  23. EGFR-targeted therapy is an attractive option for head and neck squamous cell carcinoma patients. We have recently reported the use of EGFR inhibitors as an adjunct treatment to enhance HLA-DR expression in tu...

    Authors: Takumi Kumai, Kensuke Oikawa, Naoko Aoki, Shoji Kimura, Yasuaki Harabuchi, Esteban Celis and Hiroya Kobayashi
    Citation: Journal of Translational Medicine 2014 12:265
  24. Recently, miR-10b is identified as a miRNA highly expressed in many human cancers, promoting cell migration and invasion. However, the specific function of miR-10b in hepatocellular carcinoma (HCC) is unclear ...

    Authors: Cheng-gong Liao, Ling-min Kong, Ping Zhou, Xiu-li Yang, Jian-guo Huang, He-long Zhang and Ning Lu
    Citation: Journal of Translational Medicine 2014 12:234
  25. Angiogenesis plays a pivotal role in malignant tumour growth and the metastatic process. We analysed the prognostic value of two angiogenesis parameters, microRNA-126 (miRNA-126) and microvessel density (MVD),...

    Authors: Torben Frøstrup Hansen, Sanne Kjær-Frifeldt, Søren Morgenthaler, Thorarinn Blondal, Jan Lindebjerg, Anders Jakobsen and Flemming Brandt Sørensen
    Citation: Journal of Translational Medicine 2014 12:254
  26. The treatment of oral squamous cell carcinoma (OSCC) following early detection is associated with good outcomes. Therefore, the survival and prognosis of OSCC patients could be hugely improved by identifying r...

    Authors: Yi-Hui Lai, Ru-Yin He, Jian-Liang Chou, Michael W-Y Chan, Yu-Fen Li and Chien-Kuo Tai
    Citation: Journal of Translational Medicine 2014 12:237
  27. Expression of the long non-coding RNA (lncRNA) LOC285194 was previously shown to be correlated with aggressive clinicopathological features and poor prognosis in several cancers. The aim of the present study w...

    Authors: Yu-suo Tong, Xi-lei Zhou, Xiao-wei Wang, Qing-quan Wu, Tong-xin Yang, Jin Lv, Jin-song Yang, Bin Zhu and Xiu-feng Cao
    Citation: Journal of Translational Medicine 2014 12:233
  28. Epithelial ovarian carcinoma is the most lethal gynecological cancer due to its silent onset and recurrence with resistance to chemotherapy. Overexpression of oncogene c-Myc is one of the most frequently encou...

    Authors: Jiandong Wang, Xiaoli Ma, Hannah M Jones, Leo Li-Ying Chan, Fang Song, Weiyuan Zhang, Victoria L Bae-Jump and Chunxiao Zhou
    Citation: Journal of Translational Medicine 2014 12:226
  29. Esophageal squamous cell carcinoma (ESCC) is the major histological type of esophageal cancer in developing countries. The prognosis and survival rate of ESCC are very poor. Recently, microRNAs (miRNAs) have e...

    Authors: Heping Li, Dayong Zheng, Bing Zhang, Liangshuai Liu, Junwei Ou, Wei Chen, Shiqiu Xiong, Yong Gu and Jianyong Yang
    Citation: Journal of Translational Medicine 2014 12:196
  30. Inflammatory factors play a vital role in the progression of liver cancer, although exact factors and related mechanisms still remain unclear. The present study aimed at screening inflammatory factors related ...

    Authors: Xiaojing Xu, Peixin Huang, Biwei Yang, Xiangdong Wang and Jinglin Xia
    Citation: Journal of Translational Medicine 2014 12:193
  31. As a surface glycoprotein, CD147 is capable of stimulating the production of matrix metalloproteinases (MMPs) from neighboring fibroblasts. The aim of the present study is to explore the role of soluble CD147 ...

    Authors: Jiao Wu, Zhi-Wei Hao, You-Xu Zhao, Xiang-Min Yang, Hao Tang, Xin Zhang, Fei Song, Xiu-Xuan Sun, Bin Wang, Gang Nan, Zhi-Nan Chen and Huijie Bian
    Citation: Journal of Translational Medicine 2014 12:190
  32. Disulfiram (DS), an anti-alcoholism drug, demonstrates strong antitumor activity in a copper (Cu)-dependent manner. This study investigates the cytotoxicity of DS/Cu complex in lymphoid malignant cell lines in vi...

    Authors: Jie Zha, Feili Chen, Huijuan Dong, Pengcheng Shi, Yao Yao, Yanyan Zhang, Rongwei Li, Shiyun Wang, Peng Li, Weiguang Wang and Bing Xu
    Citation: Journal of Translational Medicine 2014 12:163
  33. Tumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology...

    Authors: Peter D Caie, Arran K Turnbull, Susan M Farrington, Anca Oniscu and David J Harrison
    Citation: Journal of Translational Medicine 2014 12:156
  34. Nuclear factor-κB (NF-κB) induces a variety of biological processes through transcriptional gene control whose products are components in various signaling pathways. MicroRNAs are a small endogenous non-coding...

    Authors: Jian Zhang, Haidong Wu, Pu Li, Yanzheng Zhao, Min Liu and Hua Tang
    Citation: Journal of Translational Medicine 2014 12:155
  35. The goal of this study was to investigate the expression of sarcosine metabolism-related proteins, namely glycine N-methyltransferase (GNMT), sarcosine dehydrogenase (SARDH), and l-pipecolic acid oxidase (PIPOX),...

    Authors: Ja Kyung Yoon, Do Hee Kim and Ja Seung Koo
    Citation: Journal of Translational Medicine 2014 12:149
  36. Anti-angiogenic therapy inhibits tumor growth and is considered as a potential clinical therapy for malignant glioma. However, inevitable recurrences and unexpected tumor resistance, particularly increased inv...

    Authors: Cheng-Shi Xu, Ze-Fen Wang, Li-Ming Dai, Sheng-Hua Chu, Ling-Ling Gong, Ming-Huan Yang and Zhi-Qiang Li
    Citation: Journal of Translational Medicine 2014 12:148
  37. The use of autoantibodies for the early detection of breast cancer has generated much interest as antibodies can be readily assayed in serum when antigen levels are low. Ideally, diagnostic autoantibodies woul...

    Authors: Jianning Mao, Jon Ladd, Ekram Gad, Lauren Rastetter, Melissa M Johnson, Edmond Marzbani, Jennifer S Childs, Hailing Lu, Yushe Dang, Elizabeth Broussard, Sasha E Stanton, Sam M Hanash and Mary L Disis
    Citation: Journal of Translational Medicine 2014 12:121
  38. Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite current therapeutic advances, still confer a poor outcome to half of the patients. As other solid tumors, STSs exhibit high glucose consumpt...

    Authors: Céline Pinheiro, Valter Penna, Filipa Morais-Santos, Lucas F Abrahão-Machado, Guilherme Ribeiro, Emílio C Curcelli, Marcus V Olivieri, Sandra Morini, Isabel Valença, Daniela Ribeiro, Fernando C Schmitt, Rui M Reis and Fátima Baltazar
    Citation: Journal of Translational Medicine 2014 12:118
  39. We studied whether thymidylate synthase (TS) genotype has an independent prognostic/predictive impact on a European population of advanced non-small cell lung cancer (NSCLC) patients receiving pemetrexed.

    Authors: Estefanía Arévalo, Eduardo Castañón, Inés López, Josefa Salgado, Víctor Collado, Marta Santisteban, María Rodríguez-Ruiz, Patricia Martín, Leire Zubiri, Ana Patiño-García, Christian Rolfo and Ignacio Gil-Bazo
    Citation: Journal of Translational Medicine 2014 12:98
  40. Reliable prognostic markers based on biopsy specimens of colorectal cancer (CRC) are currently missing. We hypothesize that assessment of T-cell infiltration in biopsies of CRC may predict patient survival and...

    Authors: Viktor H Koelzer, Alessandro Lugli, Heather Dawson, Marion Hädrich, Martin D Berger, Markus Borner, Makhmudbek Mallaev, José A Galván, Jennifer Amsler, Beat Schnüriger, Inti Zlobec and Daniel Inderbitzin
    Citation: Journal of Translational Medicine 2014 12:81
  41. Transforming growth factor β (TGF-β) signaling functions as a suppressor or a promoter in tumor development, depending on the tumor stage and type. However, the role of TGF-β signaling in nonfunctioning pituit...

    Authors: Li Zhenye, Li Chuzhong, Wu Youtu, Lan Xiaolei, Cao Lei, Hong Lichuan, Wang Hongyun, Wu Yonggang, Wang Fei and Zhang Yazhuo
    Citation: Journal of Translational Medicine 2014 12:71
  42. The cross talk between the stroma and cancer cells plays a major role in phenotypic modulation. During peritoneal carcinomatosis ovarian cancer cells interact with mesenchymal stem cells (MSC) resulting in inc...

    Authors: Raphael Lis, Cyril Touboul, Najeeb M Halabi, Abishek Sainath Madduri, Denis Querleu, Jason Mezey, Joel A Malek, Karsten Suhre and Arash Rafii
    Citation: Journal of Translational Medicine 2014 12:59
  43. Recently, involvement of the chemokine/receptor system CCL20/CCR6 in colorectal cancer (CRC) progression was shown. Here, we analyzed the functional interaction of miRNA-518-5p (miR-518a-5p) with CCR6 and its ...

    Authors: Claudia Rubie, Bianca Kruse, Vilma Oliveira Frick, Kathrin Kölsch, Pirus Ghadjar, Mathias Wagner, Friedrich Grässer, Stefan Wagenpfeil and Mathias Glanemann
    Citation: Journal of Translational Medicine 2014 12:48
  44. Stents are recommended in patients with dysphagia caused by esophageal stricture, but an ideal stent does not currently exist. Thus, studies on new esophageal stents are necessary, and suitable animal models a...

    Authors: Jin Huang, Jinquan Shuang, Guanyin Xiong, Xiang Wang, Yin Zhang, Xiaowei Tang, Zhining Fan, Yingzhou Shen, Hanming Song and Zhi Liu
    Citation: Journal of Translational Medicine 2014 12:40
  45. miR-200b has been reported to be a tumor suppressor and a promising therapeutic target in cancer. miR-200b has been associated with epithelial-mesenchymal transition and chemo-resistance in cancer. The aim of ...

    Authors: Feng Ye, Hailin Tang, Qing Liu, Xinhua Xie, Minqing Wu, Xiaoping Liu, Bo Chen and Xiaoming Xie
    Citation: Journal of Translational Medicine 2014 12:17
  46. Estrogen receptor-alpha36 (ER-α36) is a new isoform of estrogen receptors without transcriptional activation domains of the classical ER-α(ER − α66). ER-α36 is mainly located in cytoplasm and plasma membrane. ...

    Authors: Yu Gu, Tianxiang Chen, Elena López, Weizhu Wu, Xiangdong Wang, Jiang Cao and Lisong Teng
    Citation: Journal of Translational Medicine 2014 12:16
  47. The interaction between tumor cells and inflammatory cells has not been systematically investigated in esophageal squamous cell carcinoma (ESCC). The main aims of the study were to investigate the clinical sig...

    Authors: Jianbo Wang, Yibin Jia, Nana Wang, Xiaomei Zhang, Bingxu Tan, Guangyu Zhang and Yufeng Cheng
    Citation: Journal of Translational Medicine 2014 12:7

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