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Cancer microenvironment

Section edited by Davide Bedognetti

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles

Anovel non-hodgkin lymphoma murine model closer to the standard clinical scenario A novel non-Hodgkin lymphoma murine model closer to the standard clinical scenario
Thais Bascuas, et al

Impact of agin on host immune response and survival in melanomaImpact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts
Sarah A. Weiss, et al

Differential tumour infiltration by T-Cells characterises intrinsic molecular subtypes in breast cancerDifferential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer
M. Miyan, J, et al

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  1. Content type: Research

    Cervical cancer is the third most common cancer in women worldwide. The most common histopathological subtype is cervical squamous cell carcinoma (SCC, 75-80%), followed by adenocarcinoma (AC) and adenosquamou...

    Authors: Vivian M Spaans, Alexander AW Peters, Gert Jan Fleuren and Ekaterina S Jordanova

    Citation: Journal of Translational Medicine 2012 10:184

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  2. Content type: Review

    The transforming growth factor (TGF-β) family of growth factors controls an immense number of cellular responses and figures prominently in development and homeostasis of most human tissues. Work over the past...

    Authors: Lenka Kubiczkova, Lenka Sedlarikova, Roman Hajek and Sabina Sevcikova

    Citation: Journal of Translational Medicine 2012 10:183

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  3. Content type: Research

    Increased expression of transcriptional coactivator p300 has been observed in a variety of human cancers. However, the expression status of p300 protein/mRNA in nasopharyngeal carcinoma (NPC) tissues and its c...

    Authors: Zhi-Wei Liao, Tong-Chong Zhou, Xiao-Jun Tan, Xian-Lu Song, Yuan Liu, Xing-Yuan Shi, Wen-Jin Huang, Li-Li Du, Bo-Jun Tu and Xiao-dan Lin

    Citation: Journal of Translational Medicine 2012 10:110

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  4. Content type: Research

    Zinc-alpha2-glycoprotein (AZGP1, ZAG) was recently demonstrated to be an important factor in tumor carcinogenesis. However, AZGP1 expression in hepatocellular carcinoma (HCC) and its significance remain largel...

    Authors: Yan Huang, Lin-Zi Li, Chris Zhi-Yi Zhang, Chun Yi, Li-Li Liu, Xuan Zhou, Guo-Bing Xie, Mu-Yan Cai, Yan Li and Jing-Ping Yun

    Citation: Journal of Translational Medicine 2012 10:106

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  5. Content type: Research

    Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated.

    Authors: Man-Bo Cai, Xiao-Pai Wang, Jia-Xing Zhang, Hui-Qiong Han, Chao-Chun Liu, Jin-Xin Bei, Ruo-Jun Peng, Yi Liang, Qi-Sheng Feng, Hai-Yun Wang, Li-Zhen Chen, Sha Fu, Tiebang Kang, Jian-Yong Shao and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2012 10:96

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  6. Content type: Research

    Nasopharyngeal carcinoma (NPC) is well-known for its highly metastatic characteristics, but little is known of its molecular mechanisms. New biomarkers that predict clinical outcome, in particular the ability ...

    Authors: Chang-Han Chen, Li-Yen Shiu, Li-Jen Su, Chi-Ying F Huang, Shun-Chen Huang, Chao-Cheng Huang, Yu-Fang Yin, Wei-Sheng Wang, Hsin-Ting Tsai, Fu-Min Fang, Wan-Chu Chuang, Hong-Chang Kang and Chung-Feng Hwang

    Citation: Journal of Translational Medicine 2012 10:93

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  7. Content type: Research

    Advanced endometrial cancer often shows resistance to clinical chemotherapy although potencies of anticancer drugs in vitro are promising. The disparity suggests that in vi vo microenvironments are not recapitula...

    Authors: Kenny Chitcholtan, Peter H Sykes and John J Evans

    Citation: Journal of Translational Medicine 2012 10:38

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  8. Content type: Research

    Intratumoral and circulating regulatory T cells (Tregs) have been shown to be critical in the pathogenesis of hepatocellular carcinoma (HCC). However there is limited knowledge on the alterations of regulatory...

    Authors: Tianxiang Chen, Dongli Song, Zhihui Min, Xiangdong Wang, Yu Gu, Bajin Wei, Jia Yao, Kangjie Chen, Zhijun Jiang, Haiyang Xie, Lin Zhou and Shusen Zheng

    Citation: Journal of Translational Medicine 2012 10:14

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  9. Content type: Research

    Bcl-2 is believed to contribute to melanoma chemoresistance. However, expression of Bcl-2 proteins may be different among melanomas. Thus correlations among expression of Bcl-2-related proteins and in vivo melano...

    Authors: Salvador Mena, María L Rodriguez, Angel Ortega, Sonia Priego, Elena Obrador, Miguel Asensi, Ignacio Petschen, Miguel Cerdá, Bob D Brown and José M Estrela

    Citation: Journal of Translational Medicine 2012 10:8

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  10. Content type: Research

    A large amount of information has been collected on the molecular tumorigenesis of thyroid cancer. A low expression of c-KIT gene has been reported during the transformation of normal thyroid epithelium to pap...

    Authors: Sara Tomei, Chiara Mazzanti, Ivo Marchetti, Leonardo Rossi, Katia Zavaglia, Francesca Lessi, Alessandro Apollo, Paolo Aretini, Giancarlo Di Coscio and Generoso Bevilacqua

    Citation: Journal of Translational Medicine 2012 10:7

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  11. Content type: Research

    Astrocyte elevated gene-1 (AEG-1) is associated with tumorigenesis and progression in diverse human cancers. The present study was aimed to investigate the clinical and prognostic significance of AEG-1 in sali...

    Authors: Wen-Ting Liao, Ling Guo, Yi Zhong, Yan-Heng Wu, Jun Li and Li-Bing Song

    Citation: Journal of Translational Medicine 2011 9:205

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  12. Content type: Research

    The PI3K/Akt pathway is involved in cellular survival pathways by inhibiting apoptotic processes and stimulating cell growth and proliferation. Its negative prognostic value has been proven in many types of ca...

    Authors: Andrej Valkov, Thomas K Kilvaer, Sveinung W Sorbye, Tom Donnem, Eivind Smeland, Roy M Bremnes and Lill-Tove Busund

    Citation: Journal of Translational Medicine 2011 9:200

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  13. Content type: Review

    Tumour cells communicate with the cells of their microenvironment via a series of molecular and cellular interactions to aid their progression to a malignant state and ultimately their metastatic spread. Of th...

    Authors: Thea L Rogers and Ingunn Holen

    Citation: Journal of Translational Medicine 2011 9:177

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  14. Content type: Research

    Human melanoma frequently colonizes bone marrow (BM) since its earliest stage of systemic dissemination, prior to clinical metastasis occurrence. However, how melanoma cell adhesion and proliferation mechanism...

    Authors: María Valcárcel, Lorea Mendoza, José-Julio Hernández, Teresa Carrascal, Clarisa Salado, Olatz Crende and Fernando Vidal-Vanaclocha

    Citation: Journal of Translational Medicine 2011 9:142

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  15. Content type: Research

    Metastasis is a common feature of many advanced stage cancers and metastatic spread is thought to be responsible for cancer progression. Most cancer cells are localized in the primary tumor and only a small po...

    Authors: Mirosław Andrusiewicz, Anna Szczerba, Maria Wołuń-Cholewa, Wojciech Warchoł, Ewa Nowak-Markwitz, Emilia Gąsiorowska, Krystyna Adamska and Anna Jankowska

    Citation: Journal of Translational Medicine 2011 9:130

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  16. Content type: Research

    Serum IGF-I and IGF-II levels decline with age. IGF-I replacement therapy reduces the impact of age in rats. We have recently reported that IGF-II is able to act, in part, as an analogous of IGF-I in aging rat...

    Authors: Maria Garcia-Fernandez, Inma Sierra, Juan E Puche, Lucia Guerra and Inma Castilla-Cortazar

    Citation: Journal of Translational Medicine 2011 9:123

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  17. Content type: Research

    We have previously reported that expression of the RNA- and DNA-binding protein RBM3 is associated with a good prognosis in breast cancer and ovarian cancer. In this study, the prognostic value of immunohistoc...

    Authors: Liv Jonsson, Julia Bergman, Björn Nodin, Jonas Manjer, Fredrik Pontén, Mathias Uhlén and Karin Jirström

    Citation: Journal of Translational Medicine 2011 9:114

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  18. Content type: Research

    Aurora kinase A (AURKA) is a member of serine/threonine kinase family. Several kinases belonging to this family are activated in the G2/M phase of the cell cycle being involved in mitotic chromosomal segregation....

    Authors: Marco Lo Iacono, Valentina Monica, Silvia Saviozzi, Paolo Ceppi, Enrico Bracco, Mauro Papotti and Giorgio V Scagliotti

    Citation: Journal of Translational Medicine 2011 9:100

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  19. Content type: Research

    Protein kinase CK2 is a highly conserved, ubiquitous protein serine/threonine kinase that phosphorylates many substrates and has a global role in numerous biological and pathological processes. Overexpression ...

    Authors: Jinjin Zou, Hesan Luo, Qin Zeng, Zhongyi Dong, Dehua Wu and Li Liu

    Citation: Journal of Translational Medicine 2011 9:97

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  20. Content type: Research

    Mast cells promote the progression of experimental tumors and might be a valuable therapeutic target. However, the relevant clinical evidence is still controversial. This study analyzed the relationship betwee...

    Authors: Qing Xia, Xiao-Jun Wu, Qiang Zhou, Jing-Zeng, Jing-Hui Hou, Zhi-Zhong Pan and Xiao-Shi Zhang

    Citation: Journal of Translational Medicine 2011 9:88

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  21. Content type: Research

    Preliminary experimental studies have suggested that the in situ destruction of tumor tissue by local laser ablation (LA) may also stimulate host immunity against cancer. We investigated local and systemic ind...

    Authors: Wen Xu Lin, Theodora Fifis, Caterina Malcontenti-Wilson, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Linh Nguyen and Christopher Christophi

    Citation: Journal of Translational Medicine 2011 9:83

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  22. Content type: Review

    Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, se...

    Authors: Thomas GP Grunewald, Saskia M Herbst, Jürgen Heinze and Stefan Burdach

    Citation: Journal of Translational Medicine 2011 9:79

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  23. Content type: Research

    The sulfation pattern of heparan sulfate chains influences signaling events mediated by heparan sulfate proteoglycans located on cell surface. SULF1 and SULF2 are two endosulfatases able to cleave specific 6-O...

    Authors: Caroline Bret, Jérôme Moreaux, Jean-François Schved, Dirk Hose and Bernard Klein

    Citation: Journal of Translational Medicine 2011 9:72

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  24. Content type: Research

    Implantation and growth of metastatic cancer cells at distant organs is promoted by inflammation-dependent mechanisms. A hepatic melanoma metastasis model where a majority of metastases are generated via inter...

    Authors: Clarisa Salado, Elvira Olaso, Natalia Gallot, Maria Valcarcel, Eider Egilegor, Lorea Mendoza and Fernando Vidal-Vanaclocha

    Citation: Journal of Translational Medicine 2011 9:59

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  25. Content type: Research

    Metabolic reprogramming resulting in enhanced glycolysis is a phenotypic trait of cancer cells, which is imposed by the tumor microenvironment and is linked to the down-regulation of the catalytic subunit of t...

    Authors: María Sánchez-Aragó and José M Cuezva

    Citation: Journal of Translational Medicine 2011 9:19

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  26. Content type: Research

    Despite an ever-improving understanding of the molecular biology of cancer, the treatment of most cancers has not changed dramatically in the past three decades and drugs that do not discriminate between tumor...

    Authors: Tomohisa Horibe, Masayuki Kohno, Mari Haramoto, Koji Ohara and Koji Kawakami

    Citation: Journal of Translational Medicine 2011 9:8

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  27. Content type: Research

    Integrins are heterodimeric receptors that play a critical role in cell-cell and cell-matrix adhesion processes. Among them, αVβ3 integrin, that recognizes the aminoacidic RGD triad, is reported to be involved in...

    Authors: Gaetano Santulli, Maria Felicia Basilicata, Mariarosaria De Simone, Carmine Del Giudice, Antonio Anastasio, Daniela Sorriento, Michele Saviano, Annarita Del Gatto, Bruno Trimarco, Carlo Pedone, Laura Zaccaro and Guido Iaccarino

    Citation: Journal of Translational Medicine 2011 9:7

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  28. Content type: Research

    Immunohistochemistry (IHC) with mutation-specific antibodies may be an ancillary method of detecting EGFR mutations in lung cancer patients.

    Authors: Sara Simonetti, Miguel Angel Molina, Cristina Queralt, Itziar de Aguirre, Clara Mayo, Jordi Bertran-Alamillo, José Javier Sanchez, Jose Luis Gonzalez-Larriba, Ulpiano Jimenez, Dolores Isla, Teresa Moran, Santiago Viteri, Carlos Camps, Rosario Garcia-Campelo, Bartomeu Massuti, Susana Benlloch…

    Citation: Journal of Translational Medicine 2010 8:135

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  29. Content type: Research

    Cancer invasion results from constant interactions between cancer cells and their microenvironment. Major components of the cancer microenvironment are stromal cells, infiltrating inflammatory cells, collagens...

    Authors: Chun-Wei Peng, Xiu-Li Liu, Xiong Liu and Yan Li

    Citation: Journal of Translational Medicine 2010 8:101

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  30. Content type: Research

    Esophageal adenocarcinomas (EACs) arise due to gastroesophageal reflux, with Barrett's esophagus (BE) regarded as precancerous lesion. Matrix metalloproteinases (MMPs) might play a role during the multistep ca...

    Authors: Martin Grimm, Maria Lazariotou, Stefan Kircher, Luisa Stuermer, Christoph Reiber, Andreas Höfelmayr, Stefan Gattenlöhner, Christoph Otto, Christoph T Germer and Burkhard HA von Rahden

    Citation: Journal of Translational Medicine 2010 8:99

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  31. Content type: Research

    Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation. The aim of this study was to examine the association between Oct4 and Sox2 expression levels with bo...

    Authors: Nan Ge, Huan-Xin Lin, Xiang-Sheng Xiao, Ling Guo, Hui-Min Xu, Xin Wang, Ting Jin, Xiu-Yu Cai, Yi Liang, Wei-Han Hu and Tiebang Kang

    Citation: Journal of Translational Medicine 2010 8:94

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  32. Content type: Research

    Esophageal squamous cell carcinomas (ESCC) are usually asymptomatic and go undetected until they are incurable. Cytological screening is one strategy to detect ESCC at an early stage and has shown promise in p...

    Authors: Sumana Mukherjee, Mark J Roth, Sanford M Dawsey, Wusheng Yan, Jaime Rodriguez-Canales, Heidi S Erickson, Nan Hu, Alisa M Goldstein, Philip R Taylor, Annely M Richardson, Michael A Tangrea, Rodrigo F Chuaqui and Michael R Emmert-Buck

    Citation: Journal of Translational Medicine 2010 8:91

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  33. Content type: Research

    Helicobacter pylori (H. pylori) infection is associated with chronic gastritis, peptic ulceration and gastric carcinoma. Protease-activated receptor-2 (PAR-2), which is activated by trypsin, induced the activatio...

    Authors: Joo Weon Lim and Hyeyoung Kim

    Citation: Journal of Translational Medicine 2010 8:85

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  34. Content type: Research

    This study represents the first attempt to perform a profiling analysis of the intergenerational differences in the microRNAs (miRNAs) of primary cutaneous melanocytic neoplasms in young adult and older age gr...

    Authors: Drazen M Jukic, Uma NM Rao, Lori Kelly, Jihad S Skaf, Laura M Drogowski, John M Kirkwood and Monica C Panelli

    Citation: Journal of Translational Medicine 2010 8:27

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