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Cancer Microenvironment

Section edited by Davide Bedognetti and Jessica Roelands

© © nopparit / Getty Images / iStock

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles


microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ

Research | Zhenming Jiang et al


Tumor microenvironment differences between primary tumor and brain metastases

Review | Bernardo Cacho-Díaz et al


Identification of key genes controlling breast cancer stem cell characteristics via stemness indices analysis

Research | Jianying Pei et al

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  1. Inhibitor of DNA binding 1 (Id1) and 3 (Id3) genes have been related with the inhibition of cell differentiation, cell growth promotion and tumor metastasis. Recently, Id1 has been identified as an independent...

    Authors: Eduardo Castañon, Joaquim Bosch-Barrera, Inés López, Víctor Collado, Marta Moreno, José María López-Picazo, Leire Arbea, María Dolores Lozano, Alfonso Calvo and Ignacio Gil-Bazo
    Citation: Journal of Translational Medicine 2013 11:13
    Content type: Research Published on:

  2. The chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but the role of CXCL14 in colorectal carcinoma (C...

    Authors: Jun Zeng, Xudan Yang, Lin Cheng, Rui Liu, Yunlong Lei, Dandan Dong, Fanghua Li, Quek Choon Lau, Longfei Deng, Edouard C Nice, Ke Xie and Canhua Huang
    Citation: Journal of Translational Medicine 2013 11:6
    Content type: Research Published on:

  3. The globular heads of the human C1q receptor (gC1qR) localize predominantly to the mitochondrial matrix. gC1qR mediates many biological responses, including growth perturbation, morphological abnormalities and...

    Authors: Zheng-lin Chen, Ping-qing Gu, Kangsheng Liu, Ya-juan Su and Ling-juan Gao
    Citation: Journal of Translational Medicine 2012 10:255
    Content type: Research Published on:

  4. The mechanism regarding rapid progression of residual hepatocellular carcinoma (HCC) after insufficient radiofrequency ablation (RFA) has been preliminarily discussed. However, most studies have mainly focused...

    Authors: Jian Kong, Lingqun Kong, Jinge Kong, Shan Ke, Jun Gao, Xuemei Ding, Lemin Zheng, Huichuan Sun and Wenbing Sun
    Citation: Journal of Translational Medicine 2012 10:230
    Content type: Research Published on:

  5. Breast cancers are phenotypically and genotypically heterogeneous tumors containing multiple cancer cell populations with various metastatic potential. Aggressive tumor cell subpopulations might more easily be...

    Authors: Aleksandra Markiewicz, Tomasz Ahrends, Marzena Wełnicka-Jaśkiewicz, Barbara Seroczyńska, Jarosław Skokowski, Janusz Jaśkiewicz, Jolanta Szade, Wojciech Biernat and Anna J Żaczek
    Citation: Journal of Translational Medicine 2012 10:226
    Content type: Research Published on:

  6. High endothelial venules (HEV) have been recognized to play a role in metastasis by its changes seen in the cancer microenvironment of lymph nodes (LN) and solid cancers. Squamous cell carcinoma (SCC) of the t...

    Authors: Ser Yee Lee, Chao-Nan Qian, Aik Seng Ooi, Peiyi Chen, Hui Min Bernice Wong, Swe Swe Myint, Jing Chii Wong, Siok Gek Jacqueline Hwang and Khee Chee Soo
    Citation: Journal of Translational Medicine 2012 10:206
    Content type: Research Published on:

  8. Cervical cancer is the third most common cancer in women worldwide. The most common histopathological subtype is cervical squamous cell carcinoma (SCC, 75-80%), followed by adenocarcinoma (AC) and adenosquamou...

    Authors: Vivian M Spaans, Alexander AW Peters, Gert Jan Fleuren and Ekaterina S Jordanova
    Citation: Journal of Translational Medicine 2012 10:184
    Content type: Research Published on:

  9. The transforming growth factor (TGF-β) family of growth factors controls an immense number of cellular responses and figures prominently in development and homeostasis of most human tissues. Work over the past...

    Authors: Lenka Kubiczkova, Lenka Sedlarikova, Roman Hajek and Sabina Sevcikova
    Citation: Journal of Translational Medicine 2012 10:183
    Content type: Review Published on:

  10. Increased expression of transcriptional coactivator p300 has been observed in a variety of human cancers. However, the expression status of p300 protein/mRNA in nasopharyngeal carcinoma (NPC) tissues and its c...

    Authors: Zhi-Wei Liao, Tong-Chong Zhou, Xiao-Jun Tan, Xian-Lu Song, Yuan Liu, Xing-Yuan Shi, Wen-Jin Huang, Li-Li Du, Bo-Jun Tu and Xiao-dan Lin
    Citation: Journal of Translational Medicine 2012 10:110
    Content type: Research Published on:

  11. Zinc-alpha2-glycoprotein (AZGP1, ZAG) was recently demonstrated to be an important factor in tumor carcinogenesis. However, AZGP1 expression in hepatocellular carcinoma (HCC) and its significance remain largel...

    Authors: Yan Huang, Lin-Zi Li, Chris Zhi-Yi Zhang, Chun Yi, Li-Li Liu, Xuan Zhou, Guo-Bing Xie, Mu-Yan Cai, Yan Li and Jing-Ping Yun
    Citation: Journal of Translational Medicine 2012 10:106
    Content type: Research Published on:

  12. Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated.

    Authors: Man-Bo Cai, Xiao-Pai Wang, Jia-Xing Zhang, Hui-Qiong Han, Chao-Chun Liu, Jin-Xin Bei, Ruo-Jun Peng, Yi Liang, Qi-Sheng Feng, Hai-Yun Wang, Li-Zhen Chen, Sha Fu, Tiebang Kang, Jian-Yong Shao and Yi-Xin Zeng
    Citation: Journal of Translational Medicine 2012 10:96
    Content type: Research Published on:

  13. Nasopharyngeal carcinoma (NPC) is well-known for its highly metastatic characteristics, but little is known of its molecular mechanisms. New biomarkers that predict clinical outcome, in particular the ability ...

    Authors: Chang-Han Chen, Li-Yen Shiu, Li-Jen Su, Chi-Ying F Huang, Shun-Chen Huang, Chao-Cheng Huang, Yu-Fang Yin, Wei-Sheng Wang, Hsin-Ting Tsai, Fu-Min Fang, Wan-Chu Chuang, Hong-Chang Kang and Chung-Feng Hwang
    Citation: Journal of Translational Medicine 2012 10:93
    Content type: Research Published on:

  14. Advanced endometrial cancer often shows resistance to clinical chemotherapy although potencies of anticancer drugs in vitro are promising. The disparity suggests that in vi vo microenvironments are not recapitula...

    Authors: Kenny Chitcholtan, Peter H Sykes and John J Evans
    Citation: Journal of Translational Medicine 2012 10:38
    Content type: Research Published on:

  15. Intratumoral and circulating regulatory T cells (Tregs) have been shown to be critical in the pathogenesis of hepatocellular carcinoma (HCC). However there is limited knowledge on the alterations of regulatory...

    Authors: Tianxiang Chen, Dongli Song, Zhihui Min, Xiangdong Wang, Yu Gu, Bajin Wei, Jia Yao, Kangjie Chen, Zhijun Jiang, Haiyang Xie, Lin Zhou and Shusen Zheng
    Citation: Journal of Translational Medicine 2012 10:14
    Content type: Research Published on:

  16. Bcl-2 is believed to contribute to melanoma chemoresistance. However, expression of Bcl-2 proteins may be different among melanomas. Thus correlations among expression of Bcl-2-related proteins and in vivo melano...

    Authors: Salvador Mena, María L Rodriguez, Angel Ortega, Sonia Priego, Elena Obrador, Miguel Asensi, Ignacio Petschen, Miguel Cerdá, Bob D Brown and José M Estrela
    Citation: Journal of Translational Medicine 2012 10:8
    Content type: Research Published on:

  17. A large amount of information has been collected on the molecular tumorigenesis of thyroid cancer. A low expression of c-KIT gene has been reported during the transformation of normal thyroid epithelium to pap...

    Authors: Sara Tomei, Chiara Mazzanti, Ivo Marchetti, Leonardo Rossi, Katia Zavaglia, Francesca Lessi, Alessandro Apollo, Paolo Aretini, Giancarlo Di Coscio and Generoso Bevilacqua
    Citation: Journal of Translational Medicine 2012 10:7
    Content type: Research Published on:

  18. Astrocyte elevated gene-1 (AEG-1) is associated with tumorigenesis and progression in diverse human cancers. The present study was aimed to investigate the clinical and prognostic significance of AEG-1 in sali...

    Authors: Wen-Ting Liao, Ling Guo, Yi Zhong, Yan-Heng Wu, Jun Li and Li-Bing Song
    Citation: Journal of Translational Medicine 2011 9:205
    Content type: Research Published on:

  19. The PI3K/Akt pathway is involved in cellular survival pathways by inhibiting apoptotic processes and stimulating cell growth and proliferation. Its negative prognostic value has been proven in many types of ca...

    Authors: Andrej Valkov, Thomas K Kilvaer, Sveinung W Sorbye, Tom Donnem, Eivind Smeland, Roy M Bremnes and Lill-Tove Busund
    Citation: Journal of Translational Medicine 2011 9:200
    Content type: Research Published on:

  20. Tumour cells communicate with the cells of their microenvironment via a series of molecular and cellular interactions to aid their progression to a malignant state and ultimately their metastatic spread. Of th...

    Authors: Thea L Rogers and Ingunn Holen
    Citation: Journal of Translational Medicine 2011 9:177
    Content type: Review Published on:

  21. Human melanoma frequently colonizes bone marrow (BM) since its earliest stage of systemic dissemination, prior to clinical metastasis occurrence. However, how melanoma cell adhesion and proliferation mechanism...

    Authors: María Valcárcel, Lorea Mendoza, José-Julio Hernández, Teresa Carrascal, Clarisa Salado, Olatz Crende and Fernando Vidal-Vanaclocha
    Citation: Journal of Translational Medicine 2011 9:142
    Content type: Research Published on:

  22. Metastasis is a common feature of many advanced stage cancers and metastatic spread is thought to be responsible for cancer progression. Most cancer cells are localized in the primary tumor and only a small po...

    Authors: Mirosław Andrusiewicz, Anna Szczerba, Maria Wołuń-Cholewa, Wojciech Warchoł, Ewa Nowak-Markwitz, Emilia Gąsiorowska, Krystyna Adamska and Anna Jankowska
    Citation: Journal of Translational Medicine 2011 9:130
    Content type: Research Published on:

  23. Serum IGF-I and IGF-II levels decline with age. IGF-I replacement therapy reduces the impact of age in rats. We have recently reported that IGF-II is able to act, in part, as an analogous of IGF-I in aging rat...

    Authors: Maria Garcia-Fernandez, Inma Sierra, Juan E Puche, Lucia Guerra and Inma Castilla-Cortazar
    Citation: Journal of Translational Medicine 2011 9:123
    Content type: Research Published on:

  24. We have previously reported that expression of the RNA- and DNA-binding protein RBM3 is associated with a good prognosis in breast cancer and ovarian cancer. In this study, the prognostic value of immunohistoc...

    Authors: Liv Jonsson, Julia Bergman, Björn Nodin, Jonas Manjer, Fredrik Pontén, Mathias Uhlén and Karin Jirström
    Citation: Journal of Translational Medicine 2011 9:114
    Content type: Research Published on:

  25. Aurora kinase A (AURKA) is a member of serine/threonine kinase family. Several kinases belonging to this family are activated in the G2/M phase of the cell cycle being involved in mitotic chromosomal segregation....

    Authors: Marco Lo Iacono, Valentina Monica, Silvia Saviozzi, Paolo Ceppi, Enrico Bracco, Mauro Papotti and Giorgio V Scagliotti
    Citation: Journal of Translational Medicine 2011 9:100
    Content type: Research Published on:

  26. Protein kinase CK2 is a highly conserved, ubiquitous protein serine/threonine kinase that phosphorylates many substrates and has a global role in numerous biological and pathological processes. Overexpression ...

    Authors: Jinjin Zou, Hesan Luo, Qin Zeng, Zhongyi Dong, Dehua Wu and Li Liu
    Citation: Journal of Translational Medicine 2011 9:97
    Content type: Research Published on:

  27. Mast cells promote the progression of experimental tumors and might be a valuable therapeutic target. However, the relevant clinical evidence is still controversial. This study analyzed the relationship betwee...

    Authors: Qing Xia, Xiao-Jun Wu, Qiang Zhou, Jing-Zeng, Jing-Hui Hou, Zhi-Zhong Pan and Xiao-Shi Zhang
    Citation: Journal of Translational Medicine 2011 9:88
    Content type: Research Published on:

  28. Preliminary experimental studies have suggested that the in situ destruction of tumor tissue by local laser ablation (LA) may also stimulate host immunity against cancer. We investigated local and systemic ind...

    Authors: Wen Xu Lin, Theodora Fifis, Caterina Malcontenti-Wilson, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Linh Nguyen and Christopher Christophi
    Citation: Journal of Translational Medicine 2011 9:83
    Content type: Research Published on:

  29. Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, se...

    Authors: Thomas GP Grunewald, Saskia M Herbst, Jürgen Heinze and Stefan Burdach
    Citation: Journal of Translational Medicine 2011 9:79
    Content type: Review Published on:

  30. The sulfation pattern of heparan sulfate chains influences signaling events mediated by heparan sulfate proteoglycans located on cell surface. SULF1 and SULF2 are two endosulfatases able to cleave specific 6-O...

    Authors: Caroline Bret, Jérôme Moreaux, Jean-François Schved, Dirk Hose and Bernard Klein
    Citation: Journal of Translational Medicine 2011 9:72
    Content type: Research Published on:

  31. Implantation and growth of metastatic cancer cells at distant organs is promoted by inflammation-dependent mechanisms. A hepatic melanoma metastasis model where a majority of metastases are generated via inter...

    Authors: Clarisa Salado, Elvira Olaso, Natalia Gallot, Maria Valcarcel, Eider Egilegor, Lorea Mendoza and Fernando Vidal-Vanaclocha
    Citation: Journal of Translational Medicine 2011 9:59
    Content type: Research Published on:

  32. Metabolic reprogramming resulting in enhanced glycolysis is a phenotypic trait of cancer cells, which is imposed by the tumor microenvironment and is linked to the down-regulation of the catalytic subunit of t...

    Authors: María Sánchez-Aragó and José M Cuezva
    Citation: Journal of Translational Medicine 2011 9:19
    Content type: Research Published on:

  33. Despite an ever-improving understanding of the molecular biology of cancer, the treatment of most cancers has not changed dramatically in the past three decades and drugs that do not discriminate between tumor...

    Authors: Tomohisa Horibe, Masayuki Kohno, Mari Haramoto, Koji Ohara and Koji Kawakami
    Citation: Journal of Translational Medicine 2011 9:8
    Content type: Research Published on:

  34. Integrins are heterodimeric receptors that play a critical role in cell-cell and cell-matrix adhesion processes. Among them, αVβ3 integrin, that recognizes the aminoacidic RGD triad, is reported to be involved in...

    Authors: Gaetano Santulli, Maria Felicia Basilicata, Mariarosaria De Simone, Carmine Del Giudice, Antonio Anastasio, Daniela Sorriento, Michele Saviano, Annarita Del Gatto, Bruno Trimarco, Carlo Pedone, Laura Zaccaro and Guido Iaccarino
    Citation: Journal of Translational Medicine 2011 9:7
    Content type: Research Published on:

  35. Immunohistochemistry (IHC) with mutation-specific antibodies may be an ancillary method of detecting EGFR mutations in lung cancer patients.

    Authors: Sara Simonetti, Miguel Angel Molina, Cristina Queralt, Itziar de Aguirre, Clara Mayo, Jordi Bertran-Alamillo, José Javier Sanchez, Jose Luis Gonzalez-Larriba, Ulpiano Jimenez, Dolores Isla, Teresa Moran, Santiago Viteri, Carlos Camps, Rosario Garcia-Campelo, Bartomeu Massuti, Susana Benlloch…
    Citation: Journal of Translational Medicine 2010 8:135
    Content type: Research Published on:

  37. Cancer invasion results from constant interactions between cancer cells and their microenvironment. Major components of the cancer microenvironment are stromal cells, infiltrating inflammatory cells, collagens...

    Authors: Chun-Wei Peng, Xiu-Li Liu, Xiong Liu and Yan Li
    Citation: Journal of Translational Medicine 2010 8:101
    Content type: Research Published on:

  38. Esophageal adenocarcinomas (EACs) arise due to gastroesophageal reflux, with Barrett's esophagus (BE) regarded as precancerous lesion. Matrix metalloproteinases (MMPs) might play a role during the multistep ca...

    Authors: Martin Grimm, Maria Lazariotou, Stefan Kircher, Luisa Stuermer, Christoph Reiber, Andreas Höfelmayr, Stefan Gattenlöhner, Christoph Otto, Christoph T Germer and Burkhard HA von Rahden
    Citation: Journal of Translational Medicine 2010 8:99
    Content type: Research Published on:

  39. Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation. The aim of this study was to examine the association between Oct4 and Sox2 expression levels with bo...

    Authors: Nan Ge, Huan-Xin Lin, Xiang-Sheng Xiao, Ling Guo, Hui-Min Xu, Xin Wang, Ting Jin, Xiu-Yu Cai, Yi Liang, Wei-Han Hu and Tiebang Kang
    Citation: Journal of Translational Medicine 2010 8:94
    Content type: Research Published on:

  40. Esophageal squamous cell carcinomas (ESCC) are usually asymptomatic and go undetected until they are incurable. Cytological screening is one strategy to detect ESCC at an early stage and has shown promise in p...

    Authors: Sumana Mukherjee, Mark J Roth, Sanford M Dawsey, Wusheng Yan, Jaime Rodriguez-Canales, Heidi S Erickson, Nan Hu, Alisa M Goldstein, Philip R Taylor, Annely M Richardson, Michael A Tangrea, Rodrigo F Chuaqui and Michael R Emmert-Buck
    Citation: Journal of Translational Medicine 2010 8:91
    Content type: Research Published on:

  41. Helicobacter pylori (H. pylori) infection is associated with chronic gastritis, peptic ulceration and gastric carcinoma. Protease-activated receptor-2 (PAR-2), which is activated by trypsin, induced the activatio...

    Authors: Joo Weon Lim and Hyeyoung Kim
    Citation: Journal of Translational Medicine 2010 8:85
    Content type: Research Published on:

  43. This study represents the first attempt to perform a profiling analysis of the intergenerational differences in the microRNAs (miRNAs) of primary cutaneous melanocytic neoplasms in young adult and older age gr...

    Authors: Drazen M Jukic, Uma NM Rao, Lori Kelly, Jihad S Skaf, Laura M Drogowski, John M Kirkwood and Monica C Panelli
    Citation: Journal of Translational Medicine 2010 8:27
    Content type: Research Published on:
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