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Cancer Microenvironment

Section edited by Davide Bedognetti and Jessica Roelands

© © nopparit / Getty Images / iStock

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles


microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ

Research | Zhenming Jiang et al


Tumor microenvironment differences between primary tumor and brain metastases

Review | Bernardo Cacho-Díaz et al


Identification of key genes controlling breast cancer stem cell characteristics via stemness indices analysis

Research | Jianying Pei et al

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  1. Serum IGF-I and IGF-II levels decline with age. IGF-I replacement therapy reduces the impact of age in rats. We have recently reported that IGF-II is able to act, in part, as an analogous of IGF-I in aging rat...

    Authors: Maria Garcia-Fernandez, Inma Sierra, Juan E Puche, Lucia Guerra and Inma Castilla-Cortazar
    Citation: Journal of Translational Medicine 2011 9:123
    Content type: Research Published on:

  2. We have previously reported that expression of the RNA- and DNA-binding protein RBM3 is associated with a good prognosis in breast cancer and ovarian cancer. In this study, the prognostic value of immunohistoc...

    Authors: Liv Jonsson, Julia Bergman, Björn Nodin, Jonas Manjer, Fredrik Pontén, Mathias Uhlén and Karin Jirström
    Citation: Journal of Translational Medicine 2011 9:114
    Content type: Research Published on:

  3. Aurora kinase A (AURKA) is a member of serine/threonine kinase family. Several kinases belonging to this family are activated in the G2/M phase of the cell cycle being involved in mitotic chromosomal segregation....

    Authors: Marco Lo Iacono, Valentina Monica, Silvia Saviozzi, Paolo Ceppi, Enrico Bracco, Mauro Papotti and Giorgio V Scagliotti
    Citation: Journal of Translational Medicine 2011 9:100
    Content type: Research Published on:

  4. Protein kinase CK2 is a highly conserved, ubiquitous protein serine/threonine kinase that phosphorylates many substrates and has a global role in numerous biological and pathological processes. Overexpression ...

    Authors: Jinjin Zou, Hesan Luo, Qin Zeng, Zhongyi Dong, Dehua Wu and Li Liu
    Citation: Journal of Translational Medicine 2011 9:97
    Content type: Research Published on:

  5. Mast cells promote the progression of experimental tumors and might be a valuable therapeutic target. However, the relevant clinical evidence is still controversial. This study analyzed the relationship betwee...

    Authors: Qing Xia, Xiao-Jun Wu, Qiang Zhou, Jing-Zeng, Jing-Hui Hou, Zhi-Zhong Pan and Xiao-Shi Zhang
    Citation: Journal of Translational Medicine 2011 9:88
    Content type: Research Published on:

  6. Preliminary experimental studies have suggested that the in situ destruction of tumor tissue by local laser ablation (LA) may also stimulate host immunity against cancer. We investigated local and systemic ind...

    Authors: Wen Xu Lin, Theodora Fifis, Caterina Malcontenti-Wilson, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Linh Nguyen and Christopher Christophi
    Citation: Journal of Translational Medicine 2011 9:83
    Content type: Research Published on:

  7. Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, se...

    Authors: Thomas GP Grunewald, Saskia M Herbst, Jürgen Heinze and Stefan Burdach
    Citation: Journal of Translational Medicine 2011 9:79
    Content type: Review Published on:

  8. The sulfation pattern of heparan sulfate chains influences signaling events mediated by heparan sulfate proteoglycans located on cell surface. SULF1 and SULF2 are two endosulfatases able to cleave specific 6-O...

    Authors: Caroline Bret, Jérôme Moreaux, Jean-François Schved, Dirk Hose and Bernard Klein
    Citation: Journal of Translational Medicine 2011 9:72
    Content type: Research Published on:

  9. Implantation and growth of metastatic cancer cells at distant organs is promoted by inflammation-dependent mechanisms. A hepatic melanoma metastasis model where a majority of metastases are generated via inter...

    Authors: Clarisa Salado, Elvira Olaso, Natalia Gallot, Maria Valcarcel, Eider Egilegor, Lorea Mendoza and Fernando Vidal-Vanaclocha
    Citation: Journal of Translational Medicine 2011 9:59
    Content type: Research Published on:

  10. Metabolic reprogramming resulting in enhanced glycolysis is a phenotypic trait of cancer cells, which is imposed by the tumor microenvironment and is linked to the down-regulation of the catalytic subunit of t...

    Authors: María Sánchez-Aragó and José M Cuezva
    Citation: Journal of Translational Medicine 2011 9:19
    Content type: Research Published on:

  11. Despite an ever-improving understanding of the molecular biology of cancer, the treatment of most cancers has not changed dramatically in the past three decades and drugs that do not discriminate between tumor...

    Authors: Tomohisa Horibe, Masayuki Kohno, Mari Haramoto, Koji Ohara and Koji Kawakami
    Citation: Journal of Translational Medicine 2011 9:8
    Content type: Research Published on:

  12. Integrins are heterodimeric receptors that play a critical role in cell-cell and cell-matrix adhesion processes. Among them, αVβ3 integrin, that recognizes the aminoacidic RGD triad, is reported to be involved in...

    Authors: Gaetano Santulli, Maria Felicia Basilicata, Mariarosaria De Simone, Carmine Del Giudice, Antonio Anastasio, Daniela Sorriento, Michele Saviano, Annarita Del Gatto, Bruno Trimarco, Carlo Pedone, Laura Zaccaro and Guido Iaccarino
    Citation: Journal of Translational Medicine 2011 9:7
    Content type: Research Published on:

  13. Immunohistochemistry (IHC) with mutation-specific antibodies may be an ancillary method of detecting EGFR mutations in lung cancer patients.

    Authors: Sara Simonetti, Miguel Angel Molina, Cristina Queralt, Itziar de Aguirre, Clara Mayo, Jordi Bertran-Alamillo, José Javier Sanchez, Jose Luis Gonzalez-Larriba, Ulpiano Jimenez, Dolores Isla, Teresa Moran, Santiago Viteri, Carlos Camps, Rosario Garcia-Campelo, Bartomeu Massuti, Susana Benlloch…
    Citation: Journal of Translational Medicine 2010 8:135
    Content type: Research Published on:

  15. Cancer invasion results from constant interactions between cancer cells and their microenvironment. Major components of the cancer microenvironment are stromal cells, infiltrating inflammatory cells, collagens...

    Authors: Chun-Wei Peng, Xiu-Li Liu, Xiong Liu and Yan Li
    Citation: Journal of Translational Medicine 2010 8:101
    Content type: Research Published on:

  16. Esophageal adenocarcinomas (EACs) arise due to gastroesophageal reflux, with Barrett's esophagus (BE) regarded as precancerous lesion. Matrix metalloproteinases (MMPs) might play a role during the multistep ca...

    Authors: Martin Grimm, Maria Lazariotou, Stefan Kircher, Luisa Stuermer, Christoph Reiber, Andreas Höfelmayr, Stefan Gattenlöhner, Christoph Otto, Christoph T Germer and Burkhard HA von Rahden
    Citation: Journal of Translational Medicine 2010 8:99
    Content type: Research Published on:

  17. Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation. The aim of this study was to examine the association between Oct4 and Sox2 expression levels with bo...

    Authors: Nan Ge, Huan-Xin Lin, Xiang-Sheng Xiao, Ling Guo, Hui-Min Xu, Xin Wang, Ting Jin, Xiu-Yu Cai, Yi Liang, Wei-Han Hu and Tiebang Kang
    Citation: Journal of Translational Medicine 2010 8:94
    Content type: Research Published on:

  18. Esophageal squamous cell carcinomas (ESCC) are usually asymptomatic and go undetected until they are incurable. Cytological screening is one strategy to detect ESCC at an early stage and has shown promise in p...

    Authors: Sumana Mukherjee, Mark J Roth, Sanford M Dawsey, Wusheng Yan, Jaime Rodriguez-Canales, Heidi S Erickson, Nan Hu, Alisa M Goldstein, Philip R Taylor, Annely M Richardson, Michael A Tangrea, Rodrigo F Chuaqui and Michael R Emmert-Buck
    Citation: Journal of Translational Medicine 2010 8:91
    Content type: Research Published on:

  19. Helicobacter pylori (H. pylori) infection is associated with chronic gastritis, peptic ulceration and gastric carcinoma. Protease-activated receptor-2 (PAR-2), which is activated by trypsin, induced the activatio...

    Authors: Joo Weon Lim and Hyeyoung Kim
    Citation: Journal of Translational Medicine 2010 8:85
    Content type: Research Published on:

  21. This study represents the first attempt to perform a profiling analysis of the intergenerational differences in the microRNAs (miRNAs) of primary cutaneous melanocytic neoplasms in young adult and older age gr...

    Authors: Drazen M Jukic, Uma NM Rao, Lori Kelly, Jihad S Skaf, Laura M Drogowski, John M Kirkwood and Monica C Panelli
    Citation: Journal of Translational Medicine 2010 8:27
    Content type: Research Published on:
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