Gustafson P: Soft tissue sarcoma. Epidemiology and prognosis in 508 patients. Acta Orthop Scand Suppl. 1994, 259: 1-31.
CAS
PubMed
Google Scholar
Wibmer C, Leithner A, Zielonke N, Sperl M, Windhager R: Increasing incidence rates of soft tissue sarcomas? A population-based epidemiologic study and literature review. Ann Oncol. 2010, 21: 1106-1111. 10.1093/annonc/mdp415.
Article
CAS
PubMed
Google Scholar
Engellau J, Anderson H, Rydholm A, Bauer HC, Hall KS, Gustafson P: Time dependence of prognostic factors for patients with soft tissue sarcoma: a Scandinavian Sarcoma Group Study of 338 malignant fibrous histiocytomas. Cancer. 2004, 100: 2233-2239. 10.1002/cncr.20254.
Article
PubMed
Google Scholar
Dickinson IC, Whitwell DJ, Battistuta D, Thompson B, Strobel N, Duggal A: Surgical margin and its influence on survival in soft tissue sarcoma. ANZ J Surg. 2006, 76: 104-109. 10.1111/j.1445-2197.2006.03615.x.
Article
PubMed
Google Scholar
Zagars GK, Ballo MT, Pisters PW, Pollock RE, Patel SR, Benjamin RS: Prognostic factors for disease-specific survival after first relapse of soft-tissue sarcoma: analysis of 402 patients with disease relapse after initial conservative surgery and radiotherapy. Int J Radiat Oncol Biol Phys. 2003, 57: 739-747. 10.1016/S0360-3016(03)00714-4.
Article
PubMed
Google Scholar
Raney RB, Crist WM, Maurer HM, Foulkes MA: Prognosis of children with soft tissue sarcoma who relapse after achieving a complete response. A report from the Intergroup Rhabdomyosarcoma Study I. Cancer. 1983, 52: 44-50.
Article
PubMed
Google Scholar
Kiatisevi P, Asavamongkolkul A, Phimolsarnti R, Waikakul S, Benjarassamerote S: The outcomes and prognostic factors of patients with soft-tissue sarcoma. J Med Assoc Thai. 2006, 89: 334-342.
CAS
PubMed
Google Scholar
Yang RS, Lane JM, Eilber FR, Dorey FJ, al Shaikh R, Schumacher LY: High grade soft tissue sarcoma of the flexor fossae. Size rather than compartmental status determine prognosis. Cancer. 1995, 76: 1398-1405. 10.1002/1097-0142(19951015)76:8<1398::AID-CNCR2820760815>3.0.CO;2-B.
Article
CAS
PubMed
Google Scholar
Mendenhall WM, Zlotecki RA, Hochwald SN, Hemming AW, Grobmyer SR, Cance WG: Retroperitoneal soft tissue sarcoma. Cancer. 2005, 104: 669-675. 10.1002/cncr.21264.
Article
PubMed
Google Scholar
Koea JB, Leung D, Lewis JJ, Brennan MF: Histopathologic type: an independent prognostic factor in primary soft tissue sarcoma of the extremity?. Ann Surg Oncol. 2003, 10: 432-440. 10.1245/ASO.2003.05.014.
Article
PubMed
Google Scholar
Guillou L, Aurias A: Soft tissue sarcomas with complex genomic profiles. Virchows Arch. 2009
Google Scholar
Verweij J, Baker LH: Future treatment of soft tissue sarcomas will be driven by histological subtype and molecular aberrations. Eur J Cancer. 2010, 46: 863-868. 10.1016/j.ejca.2010.01.016.
Article
CAS
PubMed
Google Scholar
Beck AH, West RB, van de RM: Gene expression profiling for the investigation of soft tissue sarcoma pathogenesis and the identification of diagnostic, prognostic, and predictive biomarkers. Virchows Arch. 2010, 456: 141-151. 10.1007/s00428-009-0774-2.
Article
CAS
PubMed
Google Scholar
Franke TF, Kaplan DR, Cantley LC: PI3K: downstream AKTion blocks apoptosis. Cell. 1997, 88: 435-437. 10.1016/S0092-8674(00)81883-8.
Article
CAS
PubMed
Google Scholar
Hager M, Haufe H, Kemmerling R, Hitzl W, Mikuz G, Moser PL: Increased activated Akt expression in renal cell carcinomas and prognosis. J Cell Mol Med. 2009, 13: 2181-2188. 10.1111/j.1582-4934.2008.00488.x.
Article
PubMed
Google Scholar
Woenckhaus J, Steger K, Sturm K, Munstedt K, Franke FE, Fenic I: Prognostic value of PIK3CA and phosphorylated AKT expression in ovarian cancer. Virchows Arch. 2007, 450: 387-395. 10.1007/s00428-006-0358-3.
Article
CAS
PubMed
Google Scholar
Tang JM, He QY, Guo RX, Chang XJ: Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer. 2006, 51: 181-191. 10.1016/j.lungcan.2005.10.003.
Article
PubMed
Google Scholar
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB: Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 2005, 4: 988-1004. 10.1038/nrd1902.
Article
CAS
PubMed
Google Scholar
Maniscalco L, Iussich S, Martin de Las MJ, Millan Y, Biolatti B, Sasaki N: Activation of AKT in feline mammary carcinoma: A new prognostic factor for feline mammary tumours. Vet J. 2011
Google Scholar
Hasselblom S, Hansson U, Olsson M, Toren L, Bergstrom A, Nilsson-Ehle H: High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Br J Haematol. 2010, 149: 560-568. 10.1111/j.1365-2141.2010.08123.x.
Article
CAS
PubMed
Google Scholar
Yoshioka A, Miyata H, Doki Y, Yasuda T, Yamasaki M, Motoori M: The activation of Akt during preoperative chemotherapy for esophageal cancer correlates with poor prognosis. Oncol Rep. 2008, 19: 1099-1107.
CAS
PubMed
Google Scholar
Baba Y, Nosho K, Shima K, Hayashi M, Meyerhardt JA, Chan AT: Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. Cancer. 2010
Google Scholar
Mori N, Kyo S, Sakaguchi J, Mizumoto Y, Ohno S, Maida Y: Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss. Cancer Sci. 2007, 98: 1881-1888. 10.1111/j.1349-7006.2007.00630.x.
Article
CAS
PubMed
Google Scholar
Tomita Y, Morooka T, Hoshida Y, Zhang B, Qiu Y, Nakamichi I: Prognostic significance of activated AKT expression in soft-tissue sarcoma. Clin Cancer Res. 2006, 12: 3070-3077. 10.1158/1078-0432.CCR-05-1732.
Article
CAS
PubMed
Google Scholar
Valkov A, Sorbye S, Kilvaer TK, Donnem T, Smeland E, Bremnes RM: Estrogen receptor and progesterone receptor are prognostic factors in soft tissue sarcomas. Int J Oncol. 2011
Google Scholar
Valkov A, Sorbye SW, Kilvaer TK, Donnem T, Smeland E, Bremnes RM: The prognostic impact of TGF-beta1, fascin, NF-kappaB and PKC-zeta expression in soft tissue sarcomas. PLoS One. 2011, 6: e17507-10.1371/journal.pone.0017507.
Article
PubMed Central
CAS
PubMed
Google Scholar
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Edited by: Fletcher CDM, Unni KK, Mertens F. 2002, Lyon: IARC press
Google Scholar
Bremnes RM, Veve R, Gabrielson E, Hirsch FR, Baron A, Bemis L: High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. J Clin Oncol. 2002, 20: 2417-2428. 10.1200/JCO.2002.08.159.
Article
CAS
PubMed
Google Scholar
Zinda MJ, Johnson MA, Paul JD, Horn C, Konicek BW, Lu ZH: AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon. Clin Cancer Res. 2001, 7: 2475-2479.
CAS
PubMed
Google Scholar
Glass DJ: PI3 kinase regulation of skeletal muscle hypertrophy and atrophy. Curr Top Microbiol Immunol. 2010, 346: 267-278. 10.1007/82_2010_78.
CAS
PubMed
Google Scholar
She QB, Solit DB, Ye Q, O'Reilly KE, Lobo J, Rosen N: The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell. 2005, 8: 287-297. 10.1016/j.ccr.2005.09.006.
Article
PubMed Central
CAS
PubMed
Google Scholar
Stoica BA, Movsesyan VA, Lea PM, Faden AI: Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. Mol Cell Neurosci. 2003, 22: 365-382. 10.1016/S1044-7431(02)00028-3.
Article
CAS
PubMed
Google Scholar
Al Saad S, Donnem T, Al Shibli K, Persson M, Bremnes RM, Busund LT: Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer. Anticancer Res. 2009, 29: 4175-4183.
PubMed
Google Scholar
Chen J, Gomes AR, Monteiro LJ, Wong SY, Wu LH, Ng TT: Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer. PLoS One. 2010, 5: e12293-10.1371/journal.pone.0012293.
Article
PubMed Central
PubMed
Google Scholar
Wang M, Wang Y, Weil B, Abarbanell A, Herrmann J, Tan J: Estrogen receptor beta mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia. Am J Physiol Regul Integr Comp Physiol. 2009, 296: R972-R978. 10.1152/ajpregu.00045.2009.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tsai EM, Wang SC, Lee JN, Hung MC: Akt activation by estrogen in estrogen receptor-negative breast cancer cells. Cancer Res. 2001, 61: 8390-8392.
CAS
PubMed
Google Scholar
Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T: Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 2001, 15: 2203-2208. 10.1101/gad.913901.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kato S, Iida S, Higuchi T, Ishikawa T, Takagi Y, Yasuno M: PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. Int J Cancer. 2007, 121: 1771-1778. 10.1002/ijc.22890.
Article
CAS
PubMed
Google Scholar
Adams JR, Schachter NF, Liu JC, Zacksenhaus E, Egan SE: Elevated PI3K signaling drives multiple Breast Cancer subtypes. Oncotarget. 2011
Google Scholar
Kim JG, Chae YS, Sohn SK, Kang BW, Moon JH, Lee SJ: Clinical significance of genetic variations in the PI3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer. Oncology. 2010, 79: 278-282. 10.1159/000320761.
Article
CAS
PubMed
Google Scholar
Janssen EA, Soiland H, Skaland I, Gudlaugson E, Kjellevold KH, Nysted A: Comparing the prognostic value of PTEN and Akt expression with the Mitotic Activity Index in adjuvant chemotherapy-treated node-negative breast cancer patients aged <55 years. Cell Oncol. 2007, 29: 25-35.
CAS
PubMed
Google Scholar
Le Page C, Koumakpayi IH, Alam-Fahmy M, Mes-Masson AM, Saad F: Expression and localisation of Akt-1, Akt-2 and Akt-3 correlate with clinical outcome of prostate cancer patients. Br J Cancer. 2006, 94: 1906-1912. 10.1038/sj.bjc.6603184.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gazitt Y, Kolaparthi V, Moncada K, Thomas C, Freeman J: Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. Int J Oncol. 2009, 34: 551-561.
CAS
PubMed
Google Scholar
Mayeenuddin LH, Yu Y, Kang Z, Helman LJ, Cao L: Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-x(L). Oncogene. 2010, 29: 6367-6377. 10.1038/onc.2010.364.
Article
PubMed Central
CAS
PubMed
Google Scholar