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Translational Signaling and System Biology

Section edited by Marcello Maggiolini

© © selvanegra / Getty Images / iStock

The Translational Signaling and System Biology section aims to uncover pivotal transduction signaling involved in pathophysiological processes toward a translational impact on the discovery of novel targets and therapeutics. 

The section welcomes research and review articles providing new mechanistic insights on a broad range of fields such as cancer, cardiovascular biology, neuroscience, metabolism, inflammation, immunology, microbiology, drug action also through new formulations and delivery methods, novel cellular and animal models, computational and systems biology, innovative laboratory concepts fostering translational research from the bench to the bedside.

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  1. Hepatocellular carcinoma (HCC), as the most common type of liver cancer, is characterized by high recurrence and metastasis. Circular RNA (circRNA) circ_0036412 was selected for studying the underlying mechani...

    Authors: Liyan Wang, Bin Li, Xiaoyuan Yi, Xuhua Xiao, Qinghua Zheng and Lei Ma
    Citation: Journal of Translational Medicine 2022 20:154
  2. Oral squamous cell carcinoma (OSCC), as one of the commonest malignancies showing poor prognosis, has been increasingly suggested to be modulated by circular RNAs (circRNAs). Through GEO (Gene Expression Omnib...

    Authors: Liang Rong, Bo Chen, Ke Liu, Bingyao Liu, Xinyao He, Juan Liu, Junxia Li, Maodian He, Lei Zhu, Ke Liu, Xiaolei Shi, Yi Shuai and Lei Jin
    Citation: Journal of Translational Medicine 2022 20:148
  3. Adiponectin is an adipocyte-secreted cytokine that enhances insulin sensitivity and attenuates inflammation. Although circulating adiponectin level is often inversely associated with several malignancies, its...

    Authors: Zongmeng Zhang, Jinlin Du, Hui Shi, Shuai Wang, Yunjing Yan, Qihua Xu, Sujin Zhou, Zhenggang Zhao, Yunping Mu, Chaonan Qian, Allan Zijian Zhao, Sumei Cao and Fanghong Li
    Citation: Journal of Translational Medicine 2022 20:89
  4. Colon cancer is a common malignant tumor of the digestive tract, and its incidence is ranked third among gastrointestinal tumors. The present study aims to investigate the role of a novel circular RNA (circCSP...

    Authors: Jin Wang, Lei Zhou, Bingxin Chen, Zhuwen Yu, Jianglei Zhang, Zhe Zhang, Chenrui Hu, Yanjin Bai, Xiaokang Ruan, Shengjia Wang, Jun Ouyang, Airong Wu and Xin Zhao
    Citation: Journal of Translational Medicine 2022 20:58
  5. Gastric cancer (GC) is the fifth leading cause of cancer-related death worldwide and is accompanied by low diagnosis and survival rates. The molecular mechanism of GC must be elucidated to improve treatment st...

    Authors: Zhijun Geng, Jing Li, Sandang Li, Yueyue Wang, Lele Zhang, Qiuzi Hu, Xinru Wang, Lugen Zuo, Xue Song, Xiaofeng Zhang, Sitang Ge and Jianguo Hu
    Citation: Journal of Translational Medicine 2022 20:50
  6. The aberrant expression of E3 ubiquitin ligase Pellino-1 (PELI1) contributes to several human cancer development and progression. However, its expression patterns and functional importance in papillary thyroid...

    Authors: Tingting Zheng, Youxing Zhou, Xiaowei Xu, Xin Qi, Jiameng Liu, Yanan Pu, Shan Zhang, Xuerong Gao, Xinkai Luo, Mei Li, Xuefeng Wang, Liyang Dong, Ying Wang and Chaoming Mao
    Citation: Journal of Translational Medicine 2022 20:20