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Translational Cancer Biology

Section edited by Cristina Maccalli

This section aims to provide a platform for the communication and dissemination of advances in cancer biology and their translational applications. Studies considered for publication include those dissecting the mechanisms of transformation, progression and metastatization, the biology of cancer stem cells and their immunological properties, the mechanisms undergoing the epithelial-to mesenchymal (EMT) transition and tumor dormancy, their relationship with immune functions and the mechanisms undergoing cancer resistance to therapies. 

This section is also dedicated to those investigations dedicated to the translational aspects and the development of novel therapies related to the aforementioned themes and the identification of patient’s responsiveness and outcome to therapies.

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  1. Generally, cancer cells undergo metabolic reprogramming to adapt to energetic and biosynthetic requirements that support their uncontrolled proliferation. However, the mutual relationship between two critical ...

    Authors: Guoshu Bi, Yunyi Bian, Jiaqi Liang, Jiacheng Yin, Runmei Li, Mengnan Zhao, Yiwei Huang, Tao Lu, Cheng Zhan, Hong Fan and Qun Wang
    Citation: Journal of Translational Medicine 2021 19:219
    Content type: Research Published on:

  2. Eukaryotic translation initiation factor 6 (eIF6) has a crucial function in the maturation of 60S ribosomal subunits, and it controls the initiation of protein translation. Although emerging studies indicate t...

    Authors: Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen and Hong Shen
    Citation: Journal of Translational Medicine 2021 19:216
    Content type: Research Published on:

  3. As a significant cause of malignancy mortality, gastric carcinoma (GC) has been well documented to be an often-fatal diagnosis. Despite the limitations of effective therapy, immunotherapy has emerged as a prom...

    Authors: Qianmei Fu, Xiaohong Tan, Huaming Tang and Jijiang Liu
    Citation: Journal of Translational Medicine 2021 19:210
    Content type: Research Published on:

  4. Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of renal malignancy. Methyltransferase like 13 (METTL13) functions as an oncogene in most of human cancers, but its function and m...

    Authors: Zhuonan Liu, Tianshui Sun, Chiyuan Piao, Zhe Zhang and Chuize Kong
    Citation: Journal of Translational Medicine 2021 19:209
    Content type: Research Published on:

  5. Tumor metastasis is the main cause of death of cancer patients, and cancer stem cells (CSCs) is the basis of tumor metastasis. However, systematic analysis of the stemness of prostate cancer cells is still not...

    Authors: Zao Dai and Ping Liu
    Citation: Journal of Translational Medicine 2021 19:206
    Content type: Research Published on:

  6. Lung cancer is one of the most widely spread cancers in the world and half of the non-small cell lung cancers are lung adenocarcinoma (LUAD). Although there were several drugs been approved for LUAD therapy, a...

    Authors: Guangyan Kan, Ziyang Wang, Chunjie Sheng, Chen Yao, Yizhi Mao and Shuai Chen
    Citation: Journal of Translational Medicine 2021 19:161
    Content type: Research Published on:

  8. CKLF like MARVEL transmembrane domain containing 6 (CMTM6) has been associated with the development in many kinds of cancers. However, the roles of CMTM6 in hepatocellular carcinoma (HCC) are largely unknown. ...

    Authors: Xiaoting Huang, Leyang Xiang, Baiyao Wang, Jijie Hu, Chunshan Liu, Anbang Ren, Kunpeng Du, Gengtai Ye, Yingying Liang, Yunqiang Tang, Dinghua Yang and Yawei Yuan
    Citation: Journal of Translational Medicine 2021 19:120
    Content type: Research Published on:

  9. Glucose-regulating protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum (ER) that promotes folding and assembly of proteins, controls the quality of proteins, and regulates ER stress signal...

    Authors: Shengkai Xia, Wenzhe Duan, Wenwen Liu, Xinri Zhang and Qi Wang
    Citation: Journal of Translational Medicine 2021 19:118
    Content type: Review Published on:

  10. Bladder cancer (BCa) is a common malignancy characterized by high heterogeneity, yet the current treatment modalities are limited. The aim of the present investigation was to unravel the functional role of Kar...

    Authors: Fanchang Zeng, Liumei Luo, Daoyuan Li, Juncheng Guo and Min Guo
    Citation: Journal of Translational Medicine 2021 19:112
    Content type: Research Published on:

  11. Ovarian cancer (OV) is the deadliest gynecological cancer. Transmembrane protein 119 (TMEM119) has been reported as oncogene in several human cancers. However, the function of TMEM119 in OV is still poorly known.

    Authors: Tianshui Sun, Fangfang Bi, Zhuonan Liu and Qing Yang
    Citation: Journal of Translational Medicine 2021 19:111
    Content type: Research Published on:

  12. As a significant cause of cancer deaths worldwide, breast cancer continues to be a troublesome malignancy. Long non-coding RNAs (lncRNAs) have been implicated in the development of breast cancer. Abnormal meth...

    Authors: Aixia Hu, Fan Hong, Daohong Li, Yuwei Jin, Lingfei Kon, Ziguang Xu, Hui He and Qi Xie
    Citation: Journal of Translational Medicine 2021 19:95
    Content type: Research Published on:

  13. Nasopharyngeal carcinoma (NPC) is one of the most common malignancy in head and neck. With the development of treatments, the prognosis has improved these years, but metastasis is still the main cause of treat...

    Authors: Hui Tian, Si Shi, Bo You, Qicheng Zhang, Miao Gu and Yiwen You
    Citation: Journal of Translational Medicine 2021 19:77
    Content type: Research Published on:

  14. Studies of molecular mechanisms underlying tumor cell signaling highlighted a critical role for kinases in carcinogenesis and cancer progression. To this regard, protein kinases regulates a number of critical ...

    Authors: Francesca Benedetti, Sabrina Curreli, Robert C. Gallo and Davide Zella
    Citation: Journal of Translational Medicine 2021 19:60
    Content type: Research Published on:

  15. Colorectal cancer (CRC) is a common malignant tumor globally. Meanwhile, LINC01116 has been proposed as risk factor for various tumors, including CRC. But the regulation of LINC01116 in CRC required more valid...

    Authors: Weijie Liang, Jie Wu and Xinguang Qiu
    Citation: Journal of Translational Medicine 2021 19:45
    Content type: Research Published on:

  16. Non-small cell lung cancer (NSCLC) is a common type of lung cancer. Extracellular vehicles (EVs) are nano-sized particles containing proteins, lipids, and miRNAs secreted by various cells, which play important...

    Authors: Liming Gao, Qi Tian, Tong Wu, Shanshan Shi, Xiaobo Yin, Lijie Liu, Lei Zheng, Ping Wang, Yaling Tian and Shufeng Xu
    Citation: Journal of Translational Medicine 2021 19:37
    Content type: Research Published on:

  17. The ability of tumor cells to spread from their origin place and form secondary tumor foci is determined by the epithelial–mesenchymal transition process. In epithelial tumors such as prostate cancer (PCa), th...

    Authors: Martyna Parol, Arkadiusz Gzil, Magdalena Bodnar and Dariusz Grzanka
    Citation: Journal of Translational Medicine 2021 19:28
    Content type: Review Published on:

  20. Driver genes of GBM may be crucial for the onset of isocitrate dehydrogenase (IDH)-wildtype (WT) glioblastoma (GBM). However, it is still unknown whether the genes are expressed in the identical cluster of cells....

    Authors: Seon-Jin Yoon, Hye Young Son, Jin-Kyoung Shim, Ju Hyung Moon, Eui-Hyun Kim, Jong Hee Chang, Wan Yee Teo, Se Hoon Kim, Sahng Wook Park, Yong-Min Huh and Seok-Gu Kang
    Citation: Journal of Translational Medicine 2020 18:482
    Content type: Research Published on:

  21. Platelet derived growth factor receptor alpha (PDGFRα) has been considered as a relevant factor in tumor proliferation, angiogenesis and metastatic dissemination. It was a target of tyrosine kinase (TK) inhibi...

    Authors: Nadia Ben Jemii, Haifa Tounsi-Kettiti, Hamza Yaiche, Najla Mezghanni, Amira Jaballah Gabteni, Emna Fehri, Chayma Ben Fayala, Sonia Abdelhak and Samir Boubaker
    Citation: Journal of Translational Medicine 2020 18:440
    Content type: Research Published on:

  22. Cancer stem cells (CSCs) play an important role in drug resistance, recurrence, and metastasis of tumors. Considering the heterogeneity of tumors, this study aimed to explore the key genes regulating stem cell...

    Authors: Rui Guo, Aining Chu and Yuehua Gong
    Citation: Journal of Translational Medicine 2020 18:418
    Content type: Research Published on:

  23. Molecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition (PMT) of glioma is known to be associated with aggressive phenotypes,...

    Authors: Qingyu Liang, Gefei Guan, Xue Li, Chunmi Wei, Jianqi Wu, Peng Cheng, Anhua Wu and Wen Cheng
    Citation: Journal of Translational Medicine 2020 18:378
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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