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Personalized medicine

Section edited by Lotfi Chouchane

This section aims to provide a platform for research that will revolutionize patient care through the use of novel molecular predisposing screening, diagnostic, prognostic and pharmacogenomics. Advances in human genome research are opening the door to a new paradigm for practicing medicine that promises to transform healthcare. Personalized medicine will impact the way that medicine is practiced.

Featured articles

Pharmacogenetics driving personalized medicine: analysis of genetic polymorphisms related to breast cancer medications in Italian isolated populations
Massimiliano Cocca, et al

Anti-cytokine autoantibodies in postherpetic neuralgia
Ahmad Bayat, et al



Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype
Andrea Guennoun, et al

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  1. The 235delC mutation of GJB2 gene is considered as a risk factor for the non-syndromic hearing loss (NSHL), and a significant difference in the frequency and distribution of the 235delC mutation has been describe...

    Authors: Jun Yao, Yajie Lu, Qinjun Wei, Xin Cao and Guangqian Xing
    Citation: Journal of Translational Medicine 2012 10:136
    Content type: Review Published on:

  2. High mobility group box 1(HMGB1) overexpression has been reported in a variety of human cancers. However, the role of HMGB1 in hepatocellular carcinoma (HCC) remains unclear. The aim of present study was to an...

    Authors: Furong Liu, Yaojun Zhang, Zhenwei Peng, Hengjun Gao, Li Xu and Minshan Chen
    Citation: Journal of Translational Medicine 2012 10:135
    Content type: Research Published on:

  3. There is resurgence within drug and biomarker development communities for the use of primary tumorgraft models as improved predictors of patient tumor response to novel therapeutic strategies. Despite perceive...

    Authors: David J Monsma, Noel R Monks, David M Cherba, Dawna Dylewski, Emily Eugster, Hailey Jahn, Sujata Srikanth, Stephanie B Scott, Patrick J Richardson, Robin E Everts, Aleksandr Ishkin, Yuri Nikolsky, James H Resau, Robert Sigler, Brian J Nickoloff and Craig P Webb
    Citation: Journal of Translational Medicine 2012 10:125
    Content type: Research Published on:

  4. Ovarian cancer is the most deadly gynecological cancer due to late diagnosis at advanced stage with major peritoneal involvement. To date most research has focused on primary tumor. However the prognosis is di...

    Authors: Joel A Malek, Alejandra Martinez, Eliane Mery, Gwenael Ferron, Ruby Huang, Christophe Raynaud, Eva Jouve, Jean-Paul Thiery, Denis Querleu and Arash Rafii
    Citation: Journal of Translational Medicine 2012 10:121
    Content type: Research Published on:

  5. Degummed silk fibroin from Bombyx mori (silkworm) has potential carrier capabilities for drug delivery in humans; however, the processing methods have yet to be comparatively analyzed to determine the differentia...

    Authors: Hao Zhang, Ling-ling Li, Fang-yin Dai, Hao-hao Zhang, Bing Ni, Wei Zhou, Xia Yang and Yu-zhang Wu
    Citation: Journal of Translational Medicine 2012 10:117
    Content type: Research Published on:

  6. KRAS mutations negatively affect outcome after treatment with cetuximab in metastatic colorectal cancer (mCRC) patients. As only 20% of KRAS wild type (WT) patients respond to cetuximab it is possible that other ...

    Authors: Paola Ulivi, Laura Capelli, Martina Valgiusti, Wainer Zoli, Emanuela Scarpi, Elisa Chiadini, Paola Rosetti, Sara Bravaccini, Daniele Calistri, Luca Saragoni, Andrea Casadei Gardini, Angela Ragazzini, Giovanni Luca Frassineti, Dino Amadori and Alessandro Passardi
    Citation: Journal of Translational Medicine 2012 10:87
    Content type: Research Published on:

  7. Nasopharyngeal carcinoma (NPC) is a multi-factorial malignancy closely associated with environmental factors, genetic factors and Epstein-Barr virus infection. Human leukocyte antigen (HLA) complex, specially ...

    Authors: Manli Zhao, Hongbing Cai, Xin Li, Hang Zheng, Xuexi Yang, Weiyi Fang, Longcheng Zhang, Ganguan Wei, Ming Li, Kaitai Yao and Xin Li
    Citation: Journal of Translational Medicine 2012 10:57
    Content type: Research Published on:

  8. There is no standard serum biomarker used for diagnosis or early detection of recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been...

    Authors: Martina Redova, Alexandr Poprach, Jana Nekvindova, Robert Iliev, Lenka Radova, Radek Lakomy, Marek Svoboda, Rostislav Vyzula and Ondrej Slaby
    Citation: Journal of Translational Medicine 2012 10:55
    Content type: Research Published on:

  9. MicroRNAs (miRNAs) have been recently detected in the circulation of cancer patients, where they are associated with clinical parameters. Discovery profiling of circulating small RNAs has not been reported in ...

    Authors: Xiwei Wu, George Somlo, Yang Yu, Melanie R Palomares, Arthur Xuejun Li, Weiying Zhou, Amy Chow, Yun Yen, John J Rossi, Harry Gao, Jinhui Wang, Yate-Ching Yuan, Paul Frankel, Sierra Li, Kimlin Tam Ashing-Giwa, Guihua Sun…
    Citation: Journal of Translational Medicine 2012 10:42
    Content type: Research Published on:

  10. Human genome sequencing is the process by which the exact order of nucleic acid base pairs in the 24 human chromosomes is determined. Since the completion of the Human Genome Project in 2003, genomic sequencin...

    Authors: Karen K Mestan, Leonard Ilkhanoff, Samdeep Mouli and Simon Lin
    Citation: Journal of Translational Medicine 2011 9:222
    Content type: Review Published on:
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