Personalized medicine

Further evidence for the existence of major susceptibility of nasopharyngeal carcinoma in the region near HLA-A locus in Southern Chinese

Nasopharyngeal carcinoma (NPC) is a multi-factorial malignancy closely associated with environmental factors, genetic factors and Epstein-Barr virus infection. Human leukocyte antigen (HLA) complex, specially ...

Authors: Manli Zhao, Hongbing Cai, Xin Li, Hang Zheng, Xuexi Yang, Weiyi Fang, Longcheng Zhang, Ganguan Wei, Ming Li, Kaitai Yao and Xin Li

De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer

MicroRNAs (miRNAs) have been recently detected in the circulation of cancer patients, where they are associated with clinical parameters. Discovery profiling of circulating small RNAs has not been reported in ...

Authors: Xiwei Wu, George Somlo, Yang Yu, Melanie R Palomares, Arthur Xuejun Li, Weiying Zhou, Amy Chow, Yun Yen, John J Rossi, Harry Gao, Jinhui Wang, Yate-Ching Yuan, Paul Frankel, Sierra Li, Kimlin Tam Ashing-Giwa, Guihua Sun…

Genomic sequencing in clinical trials

Human genome sequencing is the process by which the exact order of nucleic acid base pairs in the 24 human chromosomes is determined. Since the completion of the Human Genome Project in 2003, genomic sequencin...

Authors: Karen K Mestan, Leonard Ilkhanoff, Samdeep Mouli and Simon Lin

Personalized medicine: a patient - centered paradigm

Authors: Lotfi Chouchane, Ravinder Mamtani, Ashraf Dallol and Javaid I Sheikh