Personalized medicine

High expression of high mobility group box 1 (hmgb1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy

High mobility group box 1(HMGB1) overexpression has been reported in a variety of human cancers. However, the role of HMGB1 in hepatocellular carcinoma (HCC) remains unclear. The aim of present study was to an...

Authors: Furong Liu, Yaojun Zhang, Zhenwei Peng, Hengjun Gao, Li Xu and Minshan Chen

Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue

There is resurgence within drug and biomarker development communities for the use of primary tumorgraft models as improved predictors of patient tumor response to novel therapeutic strategies. Despite perceive...

Authors: David J Monsma, Noel R Monks, David M Cherba, Dawna Dylewski, Emily Eugster, Hailey Jahn, Sujata Srikanth, Stephanie B Scott, Patrick J Richardson, Robin E Everts, Aleksandr Ishkin, Yuri Nikolsky, James H Resau, Robert Sigler, Brian J Nickoloff and Craig P Webb

Gene expression analysis of matched ovarian primary tumors and peritoneal metastasis

Ovarian cancer is the most deadly gynecological cancer due to late diagnosis at advanced stage with major peritoneal involvement. To date most research has focused on primary tumor. However the prognosis is di...

Authors: Joel A Malek, Alejandra Martinez, Eliane Mery, Gwenael Ferron, Ruby Huang, Christophe Raynaud, Eva Jouve, Jean-Paul Thiery, Denis Querleu and Arash Rafii

Preparation and characterization of silk fibroin as a biomaterial with potential for drug delivery

Degummed silk fibroin from Bombyx mori (silkworm) has potential carrier capabilities for drug delivery in humans; however, the processing methods have yet to be comparatively analyzed to determine the differentia...

Authors: Hao Zhang, Ling-ling Li, Fang-yin Dai, Hao-hao Zhang, Bing Ni, Wei Zhou, Xia Yang and Yu-zhang Wu

Predictive role of multiple gene alterations in response to cetuximab in metastatic colorectal cancer: A single center study

KRAS mutations negatively affect outcome after treatment with cetuximab in metastatic colorectal cancer (mCRC) patients. As only 20% of KRAS wild type (WT) patients respond to cetuximab it is possible that other ...

Authors: Paola Ulivi, Laura Capelli, Martina Valgiusti, Wainer Zoli, Emanuela Scarpi, Elisa Chiadini, Paola Rosetti, Sara Bravaccini, Daniele Calistri, Luca Saragoni, Andrea Casadei Gardini, Angela Ragazzini, Giovanni Luca Frassineti, Dino Amadori and Alessandro Passardi

Further evidence for the existence of major susceptibility of nasopharyngeal carcinoma in the region near HLA-A locus in Southern Chinese

Nasopharyngeal carcinoma (NPC) is a multi-factorial malignancy closely associated with environmental factors, genetic factors and Epstein-Barr virus infection. Human leukocyte antigen (HLA) complex, specially ...

Authors: Manli Zhao, Hongbing Cai, Xin Li, Hang Zheng, Xuexi Yang, Weiyi Fang, Longcheng Zhang, Ganguan Wei, Ming Li, Kaitai Yao and Xin Li

Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma

There is no standard serum biomarker used for diagnosis or early detection of recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been...

Authors: Martina Redova, Alexandr Poprach, Jana Nekvindova, Robert Iliev, Lenka Radova, Radek Lakomy, Marek Svoboda, Rostislav Vyzula and Ondrej Slaby

De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer

MicroRNAs (miRNAs) have been recently detected in the circulation of cancer patients, where they are associated with clinical parameters. Discovery profiling of circulating small RNAs has not been reported in ...

Authors: Xiwei Wu, George Somlo, Yang Yu, Melanie R Palomares, Arthur Xuejun Li, Weiying Zhou, Amy Chow, Yun Yen, John J Rossi, Harry Gao, Jinhui Wang, Yate-Ching Yuan, Paul Frankel, Sierra Li, Kimlin Tam Ashing-Giwa, Guihua Sun…

Genomic sequencing in clinical trials

Human genome sequencing is the process by which the exact order of nucleic acid base pairs in the 24 human chromosomes is determined. Since the completion of the Human Genome Project in 2003, genomic sequencin...

Authors: Karen K Mestan, Leonard Ilkhanoff, Samdeep Mouli and Simon Lin

Personalized medicine: a patient - centered paradigm

Authors: Lotfi Chouchane, Ravinder Mamtani, Ashraf Dallol and Javaid I Sheikh