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Immunovirology

Section edited by Luigi Buonaguro

The Immunovirology section focuses on translational research related to virology and immunity to virus-based diseases, with a particular interest in human oncogenic viruses.

Studies focused on the role of innate, as well as adaptive, immunity in the establishment, containment and/or progression of viral infections up to cancer, including vaccine and adjuvanting strategies, will be considered for publication. Classic immunology as well as more recent, less established "omics" approaches (genomics, proteomics, immunogenomics, pharmacogenomics) will also be considered.

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  1. A major obstacle for the development of HIV vaccines is the virus’ worldwide sequence diversity. Nevertheless, the presence of T cell epitopes within conserved regions of the virus’ structural Gag protein and ...

    Authors: Anne-Marie Carola Andersson and Peter Johannes Holst

    Citation: Journal of Translational Medicine 2016 14:343

    Content type: Research

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  2. The new microcapillary and fluorescence-based EC IVD-qualified Muse™ Auto CD4/CD4% single-platform assay (EMD Millipore Corporation, Merck Life Sciences, KGaA, Darmstadt, Germany) for CD4 T cell numeration in ...

    Authors: Christian Diamant Mossoro-Kpinde, André Kouabosso, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Edouard Kokanzo, Rosine Féissona, Gérard Grésenguet and Laurent Bélec

    Citation: Journal of Translational Medicine 2016 14:326

    Content type: Research

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  3. Ebola virus (EBOV) is a Category A pathogen that is a member of Filoviridae family that causes hemorrhagic fever in humans and non-human primates. Unpredictable and devastating outbreaks of disease have recently ...

    Authors: Alfonso Rosamilia, Sarah Jacca, Giulia Tebaldi, Silvia Tiberti, Valentina Franceschi, Francesca Macchi, Sandro Cavirani, Gary Kobinger, Donald P. Knowles and Gaetano Donofrio

    Citation: Journal of Translational Medicine 2016 14:325

    Content type: Research

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  4. Many investigators detected the simian polyomavirus SV40 footprints in human brain tumors and neurologic diseases and recently it has been indicated that SV40 seems to be associated with multiple sclerosis (MS...

    Authors: Roberta Rizzo, Silvia Pietrobon, Elisa Mazzoni, Daria Bortolotti, Fernanda Martini, Massimiliano Castellazzi, Ilaria Casetta, Enrico Fainardi, Dario Di Luca, Enrico Granieri and Mauro Tognon

    Citation: Journal of Translational Medicine 2016 14:216

    Content type: Research

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  5. The FluoroSpot assay, an advancement of the ELISpot assay, enables simultaneous measurement of different analytes secreted at a single-cell level. This allows parallel detection of several cytokines secreted b...

    Authors: Nina Körber, Uta Behrends, Alexander Hapfelmeier, Ulrike Protzer and Tanja Bauer

    Citation: Journal of Translational Medicine 2016 14:175

    Content type: Methodology

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  6. We previously demonstrated that the HLA class II transactivator CIITA inhibits HIV-1 replication in T cells by competing with the viral transactivator Tat for the binding to Cyclin T1 subunit of the P-TEFb com...

    Authors: Greta Forlani, Filippo Turrini, Silvia Ghezzi, Alessandra Tedeschi, Guido Poli, Roberto S. Accolla and Giovanna Tosi

    Citation: Journal of Translational Medicine 2016 14:94

    Content type: Research

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  7. Autoimmune Addison’s disease (AAD) is caused by multiple genetic and environmental factors. Variants of genes encoding immunologically important proteins such as the HLA molecules are strongly associated with ...

    Authors: Kine Edvardsen, Alexander Hellesen, Eystein S. Husebye and Eirik Bratland

    Citation: Journal of Translational Medicine 2016 14:68

    Content type: Research

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  8. The tumor immunosuppressive microenvironment represents a major obstacle to an effective tumor-specific cellular immune response.

    Authors: Maria Tagliamonte, Annacarmen Petrizzo, Maria Napolitano, Antonio Luciano, Domenica Rea, Antonio Barbieri, Claudio Arra, Piera Maiolino, Marialina Tornesello, Gennaro Ciliberto, Franco M. Buonaguro and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2016 14:58

    Content type: Research

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  9. Research challenges associated with understanding HIV persistence during antiretroviral therapy can be categorized as temporal, spatial and combinatorial. Temporal research challenges relate to the timing of e...

    Authors: Paul W. Denton, Ole S. Søgaard and Martin Tolstrup

    Citation: Journal of Translational Medicine 2016 14:44

    Content type: Review

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  10. Human myeloid-derived suppressor cells (MDSC) have been described as a group of immature myeloid cells which exert immunosuppressive action by inhibiting function of T lymphocytes. While there is a huge scient...

    Authors: Eva Grützner, Renate Stirner, Lukas Arenz, Anastasia P. Athanasoulia, Kathrin Schrödl, Carola Berking, Johannes R. Bogner and Rika Draenert

    Citation: Journal of Translational Medicine 2016 14:2

    Content type: Methodology

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  11. In recent years the scientific literature in the field of the prostate carcinoma (PCa) pointed out on the genetic heterogeneity and mutations occurring in this tumour, while little attention was given to the c...

    Authors: Mauro Tognon and Maurizio Provenzano

    Citation: Journal of Translational Medicine 2015 13:387

    Content type: Commentary

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  12. HPV infections are detected in sexually naive children. This has raised the question about the role of early HPV infections in either protecting or predisposing to further HPV infections. HPV16-specific cell-m...

    Authors: Hanna-Mari Koskimaa, Anna Paaso, Marij J. P. Welters, Seija Grénman, Kari Syrjänen, Sjoerd H. van der Burg and Stina Syrjänen

    Citation: Journal of Translational Medicine 2015 13:370

    Content type: Research

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  13. Virus-like particles (VLPs) based on Newcastle disease virus (NDV) core proteins, M and NP, and containing two chimera proteins, F/F and H/G, composed of the respiratory syncytial virus (RSV) fusion protein (F...

    Authors: Lori McGinnes Cullen, Jorge C. G. Blanco and Trudy G. Morrison

    Citation: Journal of Translational Medicine 2015 13:350

    Content type: Research

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  14. Deep invasion of the normal surrounding tissue by primary cervical cancers is a prognostic parameter for postoperative radiotherapy and relatively worse survival. However, patients with tumor-specific immunity...

    Authors: Arko Gorter, Frans Prins, Merel van Diepen, Simone Punt and Sjoerd H. van der Burg

    Citation: Journal of Translational Medicine 2015 13:295

    Content type: Research

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  15. Helminths infections have been suggested to worsen the outcome of HIV infection by polarizing the immune response towards Th2. The purpose of this study is to determine the activity of Th2 immune response by m...

    Authors: Andargachew Mulu, Belay Anagaw, Aschalew Gelaw, Fuso Ota, Afework Kassu and Sisay Yifru

    Citation: Journal of Translational Medicine 2015 13:236

    Content type: Research

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  16. High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. Howe...

    Authors: Marta Massanella, Elisabet Gómez-Mora, Jorge Carrillo, Marta Curriu, Dan Ouchi, Jordi Puig, Eugènia Negredo, Cecilia Cabrera, Bonaventura Clotet and Julià Blanco

    Citation: Journal of Translational Medicine 2015 13:230

    Content type: Research

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  17. Filovirus virus-like particles (VLP) are strong immunogens with the potential for development into a safe, non-infectious vaccine. However, the large size and filamentous structure of this virus has heretofore...

    Authors: John H Carra, Karen A O Martins, Rowena D Schokman, Camenzind G Robinson, Jesse T Steffens and Sina Bavari

    Citation: Journal of Translational Medicine 2015 13:228

    Content type: Research

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  18. Interleukin-7 (IL-7) is a critical factor for T cell development and for maintaining and restoring homeostasis of mature T cells. Polymorphisms at α-chain of the IL-7 receptor (IL7R or CD127) gene are related ...

    Authors: María Guzmán-Fulgencio, Juan Berenguer, María A Jiménez-Sousa, Daniel Pineda-Tenor, Teresa Aldámiz-Echevarria, Pilar García-Broncano, Ana Carrero, Mónica García-Álvarez, Francisco Tejerina, Cristina Diez, Sonia Vazquez-Morón and Salvador Resino

    Citation: Journal of Translational Medicine 2015 13:206

    Content type: Research

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  19. For more than 240 million chronic HBV carriers worldwide, effective therapeutic HBV vaccines are urgently needed. Recently, we demonstrated that autophagosomes were efficient antigens carriers and capable to c...

    Authors: Meng Xue, Fei Fan, Lei Ding, Jingyu Liu, Shu Su, Pengfei Yin, Meng Cao, Wei Zhao, Hong-ming Hu and Lixin Wang

    Citation: Journal of Translational Medicine 2014 12:361

    Content type: Research

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  20. Early events in HIV infection are still poorly understood; virus derived from acute infections, the transmitted/founders IMCs, could provide more reliable information as they represent strains that established...

    Authors: Riccardo Miglietta, Claudia Pastori, Assunta Venuti, Christina Ochsenbauer and Lucia Lopalco

    Citation: Journal of Translational Medicine 2014 12:346

    Content type: Research

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  21. Understanding the mechanisms by which some individuals are able to naturally control HIV-1 infection is an important goal of AIDS research. We here describe the case of an HIV-1+ woman, CASE1, who has spontaneous...

    Authors: Marco Moroni, Silvia Ghezzi, Paolo Baroli, Silvia Heltai, Davide De Battista, Simone Pensieroso, Mariangela Cavarelli, Stefania Dispinseri, Irene Vanni, Claudia Pastori, Pietro Zerbi, Antonella Tosoni, Elisa Vicenzi, Manuela Nebuloni, Kim Wong, Hong Zhao…

    Citation: Journal of Translational Medicine 2014 12:335

    Content type: Research

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  22. MUC4 plays important roles in the malignant progression of human pancreatic cancer. But the huge length of MUC4 gene fragment restricts its functional and mechanism research. As one of its splice variants, MUC...

    Authors: Yi Zhu, Jing-Jing Zhang, Kun-Ling Xie, Jie Tang, Wen-Biao Liang, Rong Zhu, Yan Zhu, Bin Wang, Jin-Qiu Tao, Xiao-Fei Zhi, Zheng Li, Wen-Tao Gao, Kui-Rong Jiang, Yi Miao and Ze-Kuan Xu

    Citation: Journal of Translational Medicine 2014 12:309

    Content type: Research

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  23. Mutations in the tumor suppressor gene TP53 and proto-oncogene PIK3CA and alterations of p53 and PIK3CA AKT mTOR pathways are common events in several human cancers. We focused on the analysis of TP53 and PIK3CA ...

    Authors: Maria Lina Tornesello, Clorinda Annunziata, Luigi Buonaguro, Simona Losito, Stefano Greggi and Franco M Buonaguro

    Citation: Journal of Translational Medicine 2014 12:255

    Content type: Research

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  24. IL-10+ regulatory B (Bregs), CD4+Foxp3+ regulatory T (Tregs), and CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells regulate the progression of infection disease. This study aimed at examining how those cells ...

    Authors: Li Wang, Jinpeng Qiu, Lei Yu, Xiaoli Hu, Pingwei Zhao and Yanfang Jiang

    Citation: Journal of Translational Medicine 2014 12:251

    Content type: Research

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  25. Treatment with interferon-alpha (IFN-α) and ribavirin successfully clears hepatitis C virus (HCV) infection in 50% of patients infected with genotype 1. Addition of NS3-4A protease inhibitors (PIs) increases r...

    Authors: Nollaig M Bourke, Mary-Teresa O’Neill, Shahzad Sarwar, Suzanne Norris, Stephen Stewart, John E Hegarty, Nigel J Stevenson and Cliona O’Farrelly

    Citation: Journal of Translational Medicine 2014 12:206

    Content type: Research

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  26. Serum quantitative hepatitis B surface antigen (HBsAg) levels may be an important predictor of hepatitis B e antigen (HBeAg) seroconversion (SC) in HBeAg-positive chronic hepatitis B (CHB) patients during anti...

    Authors: Jiezuan Yang, Jiajia Chen, Ping Ye, Linfeng Jin, Wei Wu, Guoping Sheng and Lan-Juan Li

    Citation: Journal of Translational Medicine 2014 12:183

    Content type: Research

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  27. Hydrogen sulfide (H2S), together with nitric oxide (NO) and carbon monoxide (CO), belongs to a family of endogenous signaling mediators termed “gasotransmitters”. Recent studies suggest that H2S modulates many ce...

    Authors: Francesca Benedetti, Sergio Davinelli, Selvi Krishnan, Robert C Gallo, Giovanni Scapagnini, Davide Zella and Sabrina Curreli

    Citation: Journal of Translational Medicine 2014 12:145

    Content type: Research

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  28. Chronic hepatitis B and C are the leading causes of liver disease and liver transplantation worldwide. Ability to mount an effective immune response against both HBV and HCV is associated with spontaneous clea...

    Authors: Emily Funk, Shyam Kottilil, Bruce Gilliam and Rohit Talwani

    Citation: Journal of Translational Medicine 2014 12:129

    Content type: Review

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  29. Hepatitis C virus (HCV) is a universal health issue and a significant risk factor leading to hepatocellular carcinoma. HCV has infected approximately 170 million individuals worldwide. It is a member of Flaviv...

    Authors: Samia Afzal, Muhammad Idrees and Mazhar Hussain

    Citation: Journal of Translational Medicine 2014 12:115

    Content type: Research

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  30. Chikungunya fever (CHIKF) is a recently re-emerged mosquito transmitted viral disease caused by the chikungunya virus (CHIKV), an Alphavirus belonging to the family Togaviridae. Infection of humans with CHIKV can...

    Authors: Nitwara Wikan, Sarawut Khongwichit, Weerawat Phuklia, Sukathida Ubol, Tipparat Thonsakulprasert, Montri Thannagith, Duangrudee Tanramluk, Atchara Paemanee, Suthathip Kittisenachai, Sittiruk Roytrakul and Duncan R Smith

    Citation: Journal of Translational Medicine 2014 12:96

    Content type: Research

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  31. Human papillomavirus (HPV) infection has traditionally been regarded as a sexually transmitted disease (STD), but recent evidence implicates that an infected mother can transmit HPV to her newborn during pregn...

    Authors: Hanna-Mari Koskimaa, Anna E Paaso, Marij JP Welters, Seija E Grénman, Kari J Syrjänen, Sjoerd H van der Burg and Stina M Syrjänen

    Citation: Journal of Translational Medicine 2014 12:44

    Content type: Research

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  32. We have previously shown that a candidate idiotype vaccine, based on the IGKV3-20 light chain protein, is able to induce activation of circulating antigen presenting cells (APCs) in both HCV-positive and HCV-n...

    Authors: Annacarmen Petrizzo, Maria Tagliamonte, Maria Lina Tornesello, Franco M Buonaguro and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2014 12:11

    Content type: Research

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  33. Digestive malignancies, especially pancreatic cancer (PC), gastric cancer (GC), and colorectal cancer (CRC), still occur at persistently high rates, and disease progression in these cancers has been associated...

    Authors: Yun-Peng Peng, Yi Zhu, Jing-Jing Zhang, Ze-Kuan Xu, Zhu-Yin Qian, Cun-Cai Dai, Kui-Rong Jiang, Jun-Li Wu, Wen-Tao Gao, Qiang Li, Qing Du and Yi Miao

    Citation: Journal of Translational Medicine 2013 11:262

    Content type: Research

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  34. It has been proved that hepatitis B virus (HBV) infection alters the metastatic pattern and affects survival in colorectal cancer (CRC) and hepatocellular carcinoma (HCC), while the influence of HBV infection ...

    Authors: Xiao-li Wei, Miao-zhen Qiu, Wei-wei Chen, Ying Jin, Chao Ren, Feng Wang, Hui-yan Luo, Zhi-qiang Wang, Dong-sheng Zhang, Feng-hua Wang, Yu-hong Li and Rui-hua Xu

    Citation: Journal of Translational Medicine 2013 11:249

    Content type: Research

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  35. Forkhead box transcription factor 1 (FOXM1) has been reported to overexpress and correlate with pathogenesis in a variety of human malignancies. However, little research has been done to investigate its clinic...

    Authors: Xiaoxiao Li, Wensheng Qiu, Bin Liu, Ruyong Yao, Shihai Liu, Yasai Yao and Jun Liang

    Citation: Journal of Translational Medicine 2013 11:204

    Content type: Research

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  36. Trimeric soluble forms of HIV gp140 envelope glycoproteins represent one of the closest molecular structures compared to native spikes present on intact virus particles. Trimeric soluble gp140 have been genera...

    Authors: Maria Luisa Visciano, Maria Tagliamonte, Guillaume Stewart-Jones, Leo Heyndrickx, Guido Vanham, Marianne Jansson, Anders Fomsgaard, Berit Grevstad, Meghna Ramaswamy, Franco M Buonaguro, Maria Lina Tornesello, Priscilla Biswas, Gabriella Scarlatti and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2013 11:165

    Content type: Research

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  37. HCV is causing hundreds of cases yearly in Pakistan and has become a threat for Pakistani population. HCV E2 protein is a transmembrane protein involved in viral attachment and thus can serve as an important t...

    Authors: Sobia Idrees, Usman A Ashfaq and Saba Khaliq

    Citation: Journal of Translational Medicine 2013 11:105

    Content type: Research

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  38. The traditional smallpox vaccine, administered by scarification, was discontinued in the general population from 1980, because of the absence of new smallpox cases. However, the development of an effective pro...

    Authors: Sole Maria Pacchioni, Massimiliano Bissa, Carlo Zanotto, Carlo De Giuli Morghen, Elena Illiano and Antonia Radaelli

    Citation: Journal of Translational Medicine 2013 11:95

    Content type: Research

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  39. Human papilloma virus type 16 (HPV16)-induced gynecological cancers, in particular cervical cancers, are found in many women worldwide. The HPV16 encoded oncoproteins E6 and E7 are tumor-specific targets for t...

    Authors: Mariette I E van Poelgeest, Marij J P Welters, Edith M G van Esch, Linda F M Stynenbosch, Gijs Kerpershoek, Els L van Persijn van Meerten, Muriel van den Hende, Margriet J G Löwik, Dorien M A Berends-van der Meer, Lorraine M Fathers, A Rob P M Valentijn, Jaap Oostendorp, Gert Jan Fleuren, Cornelis J M Melief, Gemma G Kenter and Sjoerd H van der Burg

    Citation: Journal of Translational Medicine 2013 11:88

    Content type: Research

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  40. HIV-infected patients display an increased and early incidence of osteopenia/osteoporosis. We investigated whether bone metabolism disorders in HIV-infected patients are related to immune hyperactivation and p...

    Authors: Lidia Gazzola, Giusi Maria Bellistri, Camilla Tincati, Valentina Ierardi, Alessia Savoldi, Angelo Del Sole, Luca Tagliabue, Antonella d’Arminio Monforte and Giulia Marchetti

    Citation: Journal of Translational Medicine 2013 11:51

    Content type: Research

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  41. HIV-1 infection generates numerous abnormalities in the B cell compartment which can be partly reversed by antiretroviral therapy. Our aim was to evaluate the effects that re-exposure to HIV antigens might hav...

    Authors: Anuska Llano, Jorge Carrillo, Beatriz Mothe, Lidia Ruiz, Silvia Marfil, Elisabet García, Eloísa Yuste, Víctor Sánchez, Bonaventura Clotet, Julià Blanco and Christian Brander

    Citation: Journal of Translational Medicine 2013 11:48

    Content type: Research

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  42. An immunoinformatics study was conducted to determine the highly conserved antigenic epitope regions of hemagglutinin (HA) and neuraminidase (NA) genes in the humoral immunity and CD4+ and CD8+ T cellular immu...

    Authors: Ping Huang, Shouyi Yu, Changyou Wu and Lijun Liang

    Citation: Journal of Translational Medicine 2013 11:47

    Content type: Research

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  43. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by B-cell hyper-reactivity and the production of pathogenic anti-nuclear-directed auto-antibodies (Abs). B-cell ontogeny is part...

    Authors: Vincent Biajoux, Alexandre Bignon, Christelle Freitas, Valérie Martinez, Marcus Thelen, Guadalupe Lima, Juan Jakez-Ocampo, Dominique Emilie, Luis Llorente and Karl Balabanian

    Citation: Journal of Translational Medicine 2012 10:251

    Content type: Research

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  44. The use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albeit rarely, evolve into frank progressive multifocal leucoencephalopathy ...

    Authors: Roberta Mancuso, Marina Saresella, Ambra Hernis, Ivana Marventano, Cristian Ricci, Simone Agostini, Marco Rovaris, Domenico Caputo and Mario Clerici

    Citation: Journal of Translational Medicine 2012 10:248

    Content type: Research

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  45. CD4+CD25+ regulatory T cells (Tregs) play an important role in maintaining immunological tolerance to self and foreign antigens. T cell receptors (TCR) reflect the composition and function of T cells. It is not u...

    Authors: Jiezuan Yang, Ping Yi, Li Wei, Zherong Xu, Yunbo Chen, Lingling Tang and Lanjuan Li

    Citation: Journal of Translational Medicine 2012 10:193

    Content type: Research

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  46. As Chronic Fatigue Syndrome (CFS) has been known to follow Epstein-Bar virus (EBV) and other systemic infections; our objective was to describe differences in immune activation in post-infective CFS (PI-CFS) p...

    Authors: Gordon Broderick, Ben Z Katz, Henrique Fernandes, Mary Ann Fletcher, Nancy Klimas, Frederick A Smith, Maurice RG O’Gorman, Suzanne D Vernon and Renee Taylor

    Citation: Journal of Translational Medicine 2012 10:191

    Content type: Research

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  47. In China, high prevalence of HBV and HCV parallels with the growing epidemic of syphilis and HIV in the general population poses a great threat to blood safety. This study investigated the prevalence of serolo...

    Authors: Changqing Li, Xiaopu Xiao, Huimin Yin, Miao He, Jianping Li, Yudong Dai, Yongshui Fu, Jianmin Ge, Yonglin Yang, Yan Luan, Changzhou Lin, Hongxiang Zhao and Wuping Li

    Citation: Journal of Translational Medicine 2012 10:176

    Content type: Research

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  48. The relationship between Hepatitis C Virus (HCV) infection and immunosuppression is complex and multifaceted. Although HCV-related hepatocytolysis is classically interpreted as secondary to the attack by cytot...

    Authors: Anna Linda Zignego, Carlo Giannini, Laura Gragnani, Alessia Piluso and Elisa Fognani

    Citation: Journal of Translational Medicine 2012 10:158

    Content type: Review

    Published on:

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