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Immunobiology and immunotherapy

Section edited by Alessandra Cesano

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. Content type: Research

    HIV-negative, CD20-negative de novo diffuse large B-cell lymphoma (DLBCL) patients has rarely been reported. To elucidate the nature of this entity, we retrospectively reviewed the data of 1,456 consecutive de no...

    Authors: Ya-Jun Li, Zhi-Ming Li, Hui-Lan Rao, Yi Xia, Hui-Qiang Huang, Zhong-Jun Xia, Su Li, Wen-Yu Li and Wen-Qi Jiang

    Citation: Journal of Translational Medicine 2012 10:84

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  2. Content type: Methodology

    To date very few systems have been described for preclinical investigations of human cellular therapeutics in vivo. However, the ability to carry out comparisons of new cellular vaccines in vivo would be of subst...

    Authors: Stefani Spranger, Bernhard Frankenberger and Dolores J Schendel

    Citation: Journal of Translational Medicine 2012 10:30

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  3. Content type: Research

    Patients with HER2-overexpressing metastatic breast cancer, despite initially benefiting from the monoclonal antibody trastuzumab and the EGFR/HER2 tyrosine kinase inhibitor lapatinib, will eventually have pro...

    Authors: Erika Hamilton, Kimberly Blackwell, Amy C Hobeika, Timothy M Clay, Gloria Broadwater, Xiu-Rong Ren, Wei Chen, Henry Castro, Frederic Lehmann, Neil Spector, Junping Wei, Takuya Osada and H Kim Lyerly

    Citation: Journal of Translational Medicine 2012 10:28

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    The Erratum to this article has been published in Journal of Translational Medicine 2013 11:82

  4. Content type: Review

    It is widely accepted that systemic neoplastic spread is a late event in tumour progression. However, sometimes, rapidly invasive cancers are diagnosed because of appearance of metastatic lesions in absence of...

    Authors: Giulia Maria Stella, Rebecca Senetta, Adele Cassenti, Margherita Ronco and Paola Cassoni

    Citation: Journal of Translational Medicine 2012 10:12

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  5. Content type: Research

    The immune modulatory effect of granulocyte colony-stimulating factor (G-CSF) on T cells resulted in an unexpected low incidence of graft-versus-host disease (GVHD) in allogeneic peripheral blood stem cell tra...

    Authors: Li Xuan, Xiuli Wu, Yu Zhang, Zhiping Fan, Yiwen Ling, Fen Huang, Fuhua Zhang, Xiao Zhai and Qifa Liu

    Citation: Journal of Translational Medicine 2011 9:215

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  6. Content type: Commentary

    Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a ...

    Authors: Bernard A Fox, Dolores J Schendel, Lisa H Butterfield, Steinar Aamdal, James P Allison, Paolo Antonio Ascierto, Michael B Atkins, Jirina Bartunkova, Lothar Bergmann, Neil Berinstein, Cristina C Bonorino, Ernest Borden, Jonathan L Bramson, Cedrik M Britten, Xuetao Cao, William E Carson…

    Citation: Journal of Translational Medicine 2011 9:214

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  7. Content type: Research

    Treatment failure for breast cancer is frequently due to lymph node metastasis and invasion to neighboring organs. The aim of the present study was to investigate invasion- and metastasis-related genes in brea...

    Authors: Jian Pan, Li-Chao Sun, Yan-Fang Tao, Zhuan Zhou, Xiao-Li Du, Liang Peng, Xing Feng, Jian Wang, Yi-Ping Li, Ling Liu, Shui-Yan Wu, Yan-Lan Zhang, Shao-Yan Hu, Wen-Li Zhao, Xue-Ming Zhu, Guo-Liang Lou…

    Citation: Journal of Translational Medicine 2011 9:211

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  8. Content type: Research

    T-cell based immunotherapy for lung cancer (LC) could be a promising and novel therapeutic approach. Six-transmembrane epithelial antigen of the prostate (STEAP) and the polycomb group protein enhancer of zest...

    Authors: Satoshi Hayashi, Takumi Kumai, Yoshiya Matsuda, Naoko Aoki, Keisuke Sato, Shoji Kimura, Masahiro Kitada, Masatoshi Tateno, Esteban Celis and Hiroya Kobayashi

    Citation: Journal of Translational Medicine 2011 9:191

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  9. Content type: Research

    CD8+ effector cells often have an antitumor function in patients with cancer. However, CD8+Foxp3+ regulatory T cells (Tcregs) and interleukin (IL)-17-producing CD8+ T cells (Tc17 cells) also derive from the CD8+ ...

    Authors: Jiang Li, Zhou-Feng Huang, Geng Xiong, Hao-Yuan Mo, Fang Qiu, Hai-Qiang Mai, Qiu-Yan Chen, Jia He, Shu-peng Chen, Li-Min Zheng, Chao-Nan Qian and Yi-Xin Zeng

    Citation: Journal of Translational Medicine 2011 9:189

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  10. Content type: Research

    In the last years human proteomic has represented a promising tool to promote the communication between basic and clinical science.

    Authors: Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesco Ferro, Sara Galimberti, Valentina Donati, Laura Bazzichi, Stefano Bombardieri and Antonio Lucacchini

    Citation: Journal of Translational Medicine 2011 9:188

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  11. Content type: Research

    Human Leukocyte Antigen (HLA)-E is a non-classical class I HLA molecule that can be stabilized by ligands donated by other classical (HLA-A, -B, -C) and non-classical (HLA-G) family members. HLA-E engages a va...

    Authors: Maria Benevolo, Marcella Mottolese, Elisa Tremante, Francesca Rollo, Maria Grazia Diodoro, Cristiana Ercolani, Isabella Sperduti, Elisa Lo Monaco, Maurizio Cosimelli and Patrizio Giacomini

    Citation: Journal of Translational Medicine 2011 9:184

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  12. Content type: Research

    In head and neck squamous cell carcinoma (HNSCC), expression levels of the epidermal growth factor receptor (EGFR) correlate with poor prognosis and decreased survival rates. As the mechanisms responsible for ...

    Authors: Patrick J Schuler, Petra Boeckers, Rainer Engers, Edwin Boelke, Murat Bas, Jens Greve, Claudia A Dumitru, Goetz F Lehnerdt, Robert L Ferris, Pedro A Andrade Filho, Sven Brandau, Stephan Lang, Theresa L Whiteside and Thomas K Hoffmann

    Citation: Journal of Translational Medicine 2011 9:168

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  13. Content type: Methodology

    The ability to measure T-cell responses to antigens is proving critical in the field of vaccine development and for understanding immunity to pathogens, allergens and self-antigens. Although a variety of techn...

    Authors: Aron Chakera, Sophia C Bennett and Richard J Cornall

    Citation: Journal of Translational Medicine 2011 9:143

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  14. Content type: Research

    Active-specific immunotherapy used as an adjuvant therapeutic strategy is rather unexplored for cancers with poorly characterized tumor antigens like gastric cancer. The aim of this study was to augment a ther...

    Authors: Natasja K van den Engel, Dominik Rüttinger, Margareta Rusan, Robert Kammerer, Wolfgang Zimmermann, Rudolf A Hatz and Hauke Winter

    Citation: Journal of Translational Medicine 2011 9:140

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  15. Content type: Review

    T cell therapy represents an emerging and promising modality for the treatment of both infectious disease and cancer. Data from recent clinical trials have highlighted the potential for this therapeutic modali...

    Authors: Michael Kalos

    Citation: Journal of Translational Medicine 2011 9:138

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  16. Content type: Methodology

    Development of a standardized platform for the rapid expansion of tumor-infiltrating lymphocytes (TILs) with anti-tumor function from patients with limited TIL numbers or tumor tissues challenges their clinica...

    Authors: Qunrui Ye, Maria Loisiou, Bruce L Levine, Megan M Suhoski, James L Riley, Carl H June, George Coukos and Daniel J Powell Jr

    Citation: Journal of Translational Medicine 2011 9:131

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  17. Content type: Research

    Vitiligo is a common toxicity associated with immunotherapy for melanoma. Cytotoxic T lymphocytes (CTLs) against melanoma commonly target melanoma-associated antigens (MAAs) which are also expressed by melanoc...

    Authors: Gwendolen Y Chang, Holbrook E Kohrt, Tor B Stuge, Erich J Schwartz, Jeffrey S Weber and Peter P Lee

    Citation: Journal of Translational Medicine 2011 9:122

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  18. Content type: Research

    Time-dependent chemotherapeutic agents can selectively target tumor cells in susceptible phases of the cell cycle however a fraction of tumor cells in non-vulnerable cell cycle phases remain drug-resistant. Im...

    Authors: Ioannis Alagkiozidis, Andrea Facciabene, Marinos Tsiatas, Carmine Carpenito, Fabian Benencia, Sarah Adams, Zdenka Jonak, Carl H June, Daniel J Powell Jr and George Coukos

    Citation: Journal of Translational Medicine 2011 9:77

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  19. Content type: Research

    Aurora kinase ensures accurate chromosome segregation during cell cycle, maintaining genetic integrity in cell division. VX-680, a small-molecule Aurora kinase inhibitor, interferes with mitotic entry and form...

    Authors: Duo-Rong Xu, Shan Huang, Zi-Jie Long, Jia-Jie Chen, Zheng-Zhi Zou, Juan Li, Dong-Jun Lin and Quentin Liu

    Citation: Journal of Translational Medicine 2011 9:74

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  20. Content type: Meeting report

    Led by key opinion leaders in the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) provided a...

    Authors: James M Balwit, Pawel Kalinski, Vernon K Sondak, Pierre G Coulie, Elizabeth M Jaffee, Thomas F Gajewski and Francesco M Marincola

    Citation: Journal of Translational Medicine 2011 9:60

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  21. Content type: Research

    High-dose Interferon (HDI) therapy produces a clinical response and achieves relapse-free survival in 20-33% of patients with operable high risk or metastatic melanoma. However, patients may develop significan...

    Authors: Diana L Simons, Gerald Lee, John M Kirkwood and Peter P Lee

    Citation: Journal of Translational Medicine 2011 9:52

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  22. Content type: Research

    The differentiation of CD8+ T lymphocytes following priming of naïve cells is central in the establishment of the adaptive immune response. Yet, the molecular events underlying this process are not fully understo...

    Authors: Bruno Salaun, Takuya Yamamoto, Bassam Badran, Yasuko Tsunetsugu-Yokota, Antoine Roux, Lukas Baitsch, Redouane Rouas, Hussein Fayyad-Kazan, Petra Baumgaertner, Estelle Devevre, Anirudh Ramesh, Marion Braun, Daniel Speiser, Brigitte Autran, Philippe Martiat, Victor Appay…

    Citation: Journal of Translational Medicine 2011 9:44

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  23. Content type: Research

    Many peptide-based cancer vaccines have been tested in clinical trials with a limited success, mostly due to difficulties associated with peptide stability and delivery, resulting in inefficient antigen presen...

    Authors: Wenxue Ma, Trevor Smith, Vladimir Bogin, Yu Zhang, Cengiz Ozkan, Mihri Ozkan, Melanie Hayden, Stephanie Schroter, Ewa Carrier, Davorka Messmer, Vipin Kumar and Boris Minev

    Citation: Journal of Translational Medicine 2011 9:34

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  24. Content type: Research

    Infiltration of colorectal carcinomas (CRC) with T-cells has been associated with good prognosis. There are some indications that chemokines could be involved in T-cell infiltration of tumors. Selective modula...

    Authors: Klara Berencsi, Pyapalli Rani, Tianqian Zhang, Laura Gross, Michael Mastrangelo, Neal J Meropol, Dorothee Herlyn and Rajasekharan Somasundaram

    Citation: Journal of Translational Medicine 2011 9:33

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  25. Content type: Research

    Clinical trials of immunologic therapies provide opportunities to study the cellular and molecular effects of those therapies and may permit identification of biomarkers of response. When the trials are perfor...

    Authors: Walter C Olson, Mark E Smolkin, Erin M Farris, Robyn J Fink, Andrea R Czarkowski, Jonathan H Fink, Kimberly A Chianese-Bullock and Craig L Slingluff Jr

    Citation: Journal of Translational Medicine 2011 9:26

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  26. Content type: Review

    The Society for Immunotherapy of Cancer, SITC (formerly the International Society for Biological Therapy of Cancer, iSBTc), aims to improve cancer patient outcomes by advancing the science, development and app...

    Authors: James M Balwit, Patrick Hwu, Walter J Urba and Francesco M Marincola

    Citation: Journal of Translational Medicine 2011 9:18

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  27. Content type: Review

    Developing new vaccination strategies and optimizing current vaccines through heterologous prime-boost carries the promise of integrating the benefits of different yet synergistic vectors. It has been widely t...

    Authors: Adrian Bot, Zhiyong Qiu, Raymond Wong, Mihail Obrocea and Kent A Smith

    Citation: Journal of Translational Medicine 2010 8:132

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  28. Content type: Commentary

    The International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) hosted a one-day symposium at the National Institutes of Health on September 3...

    Authors: Lisa H Butterfield, Mary L Disis, Samir N Khleif, James M Balwit and Francesco M Marincola

    Citation: Journal of Translational Medicine 2010 8:130

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  29. Content type: Research

    Cytokine-induced killer (CIK) cells are typically differentiated in vitro with interferon (IFN)-γ and αCD3 monoclonal antibodies (mAb), followed by the repeated provision of interleukin (IL)-2. It is presently un...

    Authors: Giuseppina Bonanno, Paola Iudicone, Andrea Mariotti, Annabella Procoli, Annino Pandolfi, Daniela Fioravanti, Maria Corallo, Alessandro Perillo, Giovanni Scambia, Luca Pierelli and Sergio Rutella

    Citation: Journal of Translational Medicine 2010 8:129

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  30. Content type: Research

    Recent preclinical adoptive immunotherapy studies in murine models prompt to employ "proper" rather than "as many as possible" antigen-specific T cells to gain better therapeutic results. Ideally, "proper" T c...

    Authors: Anna Merlo, Riccardo Turrini, Cristina Trento, Paola Zanovello, Riccardo Dolcetti and Antonio Rosato

    Citation: Journal of Translational Medicine 2010 8:121

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  31. Content type: Research

    DNA vaccines represent an attractive approach for cancer treatment by inducing active T cell and B cell immune responses to tumor antigens. Previous studies have shown that interleukin-13 receptor α2 chain (IL...

    Authors: Hideyuki Nakashima, Toshio Fujisawa, Syed R Husain and Raj K Puri

    Citation: Journal of Translational Medicine 2010 8:116

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  32. Content type: Research

    Pegylated granulocyte colony-stimulating factor (G-CSF; pegfilgrastim) is a longer-acting form of G-CSF, whose effects on dendritic cell (DC) and regulatory T cell (Treg) mobilization, and on the in vivo and ex v...

    Authors: Giuseppina Bonanno, Annabella Procoli, Andrea Mariotti, Maria Corallo, Alessandro Perillo, Silvio Danese, Raimondo De Cristofaro, Giovanni Scambia and Sergio Rutella

    Citation: Journal of Translational Medicine 2010 8:114

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  33. Content type: Methodology

    The complex data sets generated by higher-order polychromatic flow cytometry experiments are a challenge to analyze. Here we describe Exhaustive Expansion, a data analysis approach for deriving hundreds to tho...

    Authors: Janet C Siebert, Lian Wang, Daniel P Haley, Ann Romer, Bo Zheng, Wes Munsil, Kenton W Gregory and Edwin B Walker

    Citation: Journal of Translational Medicine 2010 8:106

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  34. Content type: Research

    Tumor immune responses are first generated and metastases often begin in tumor sentinel lymph nodes (TSLN). Therefore, it is important to promote tumor immunity within this microenvironment. Mifepristone (RU48...

    Authors: Claudia Raja Gabaglia, Alexandra DeLaney, Jennifer Gee, Ramesh Halder, Frank L Graham, Jack Gauldie, Eli E Sercarz and Todd A Braciak

    Citation: Journal of Translational Medicine 2010 8:98

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  35. Content type: Research

    Antigen-loaded dendritic cells (DC) are capable of priming naïve T cells and therefore represent an attractive adjuvant for vaccine development in anti-tumor immunotherapy. Numerous protocols have been describ...

    Authors: Maja Bürdek, Stefani Spranger, Susanne Wilde, Bernhard Frankenberger, Dolores J Schendel and Christiane Geiger

    Citation: Journal of Translational Medicine 2010 8:90

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  36. Content type: Research

    Several single center studies have provided evidence of immune activation and antitumor activity of therapeutic vaccination with dendritic cells (DC) in patients with metastatic melanoma. The efficacy of this ...

    Authors: Antoni Ribas, Luis H Camacho, Sun Min Lee, Evan M Hersh, Charles K Brown, Jon M Richards, Maria Jovie Rodriguez, Victor G Prieto, John A Glaspy, Denise K Oseguera, Jackie Hernandez, Arturo Villanueva, Bartosz Chmielowski, Peggie Mitsky, Nadège Bercovici, Ernesto Wasserman…

    Citation: Journal of Translational Medicine 2010 8:89

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  37. Content type: Research

    The tumor associated antigen (TAA) gp100 was one of the first identified and has been used in clinical trials to treat melanoma patients. However, the gp100 epitope peptide restricted to HLA-A*2402 has not bee...

    Authors: Toshiyuki Baba, Marimo Sato-Matsushita, Akira Kanamoto, Akihiko Itoh, Naoki Oyaizu, Yusuke Inoue, Yutaka Kawakami and Hideaki Tahara

    Citation: Journal of Translational Medicine 2010 8:84

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  38. Content type: Research

    The oncogene CDC25B phosphatase plays an important role in cancer cell growth. We have recently reported that patients with esophageal squamous cell carcinoma (ESCC) have significantly higher serum levels of C...

    Authors: Jun Dong, Bo-hang Zeng, Li-hua Xu, Jun-ye Wang, Man-Zhi Li, Mu-sheng Zeng and Wan-li Liu

    Citation: Journal of Translational Medicine 2010 8:81

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  39. Content type: Research

    Melanoma vaccines have not been optimized. Adjuvants are added to activate dendritic cells (DCs) and to induce a favourable immunologic milieu, however, little is known about their cellular and molecular effec...

    Authors: Jochen T Schaefer, James W Patterson, Donna H Deacon, Mark E Smolkin, Gina R Petroni, Emily M Jackson and Craig L Slingluff Jr

    Citation: Journal of Translational Medicine 2010 8:79

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  40. Content type: Research

    High-dose interferon-alpha 2b (IFN-α 2b) is the only approved systemic therapy in the United States for the adjuvant treatment of melanoma. The study objective was to explore the immunomodulatory mechanism of ...

    Authors: Paolo A Ascierto, Maria Napolitano, Egidio Celentano, Ester Simeone, Giusy Gentilcore, Antonio Daponte, Mariaelena Capone, Corrado Caracò, Rosa Calemma, Gerardo Beneduce, Margherita Cerrone, Vincenzo De Rosa, Giuseppe Palmieri, Giuseppe Castello, John M Kirkwood, Francesco M Marincola…

    Citation: Journal of Translational Medicine 2010 8:76

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  41. Content type: Research

    IMP321 is a recombinant soluble LAG-3Ig fusion protein that binds to MHC class II with high avidity and mediates APC and then antigen-experienced memory CD8+ T cell activation. We report clinical and biological r...

    Authors: Chrystelle Brignone, Maya Gutierrez, Fawzia Mefti, Etienne Brain, Rosana Jarcau, Frédérique Cvitkovic, Nabil Bousetta, Jacques Medioni, Joseph Gligorov, Caroline Grygar, Manon Marcu and Frédéric Triebel

    Citation: Journal of Translational Medicine 2010 8:71

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  42. Content type: Research

    Adjuvant trastuzumab (Herceptin) treatment of breast cancer patients significantly improves their clinical outcome. Vaccination is an attractive alternative approach to provide HER-2/neu (Her2)-specific antibo...

    Authors: Håkan Norell, Isabel Poschke, Jehad Charo, Wei Z Wei, Courtney Erskine, Marie P Piechocki, Keith L Knutson, Jonas Bergh, Elisabet Lidbrink and Rolf Kiessling

    Citation: Journal of Translational Medicine 2010 8:53

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  43. Content type: Research

    In preparation for potential clinical development of Ab-01, an antagonistic antibody directed against the IL21R, studies were undertaken to address translational medicine needs that fall into four categories: ...

    Authors: Maya Arai, Sadhana Jain, Amy A Weaver, Andrew A Hill, Yongjing Guo, Andrea G Bree, Michael F Smith Jr, Scott W Allen, Edward R LaVallie, Deborah Young, Laird Bloom, Karissa Adkins and Margot O'Toole

    Citation: Journal of Translational Medicine 2010 8:51

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  44. Content type: Research

    Selective neutralization of the IL21/IL21R signaling pathway is a promising approach for the treatment of a variety of autoimmune diseases. Ab-01 is a human neutralizing anti-IL21R antibody. In order to ensure...

    Authors: Yongjing Guo, Andrew A Hill, Renee C Ramsey, Frederick W Immermann, Christopher Corcoran, Deborah Young, Edward R LaVallie, Mark Ryan, Theresa Bechard, Richard Pfeifer, Garvin Warner, Marcia Bologna, Laird Bloom and Margot O'Toole

    Citation: Journal of Translational Medicine 2010 8:50

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  45. Content type: Research

    T-cell immunodeficiency is a common feature in cancer patients, which may relate to initiation and development of tumor. Based on our previous finding, to further characterize the immune status, T cell prolife...

    Authors: Yangqiu Li, Suxia Geng, Qingsong Yin, Shaohua Chen, Lijian Yang, Xiuli Wu, Bo Li, Xin Du, Christian A Schmidt and Grzegorz K Przybylski

    Citation: Journal of Translational Medicine 2010 8:47

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  46. Content type: Research

    Combination immunotherapies can be effective against subcutaneous tumors in mice but the effect against orthotopic malignant disease is less well characterized. In particular, a combination of three agonist an...

    Authors: Jennifer A Westwood, Phillip K Darcy, Preethi Mayura Guru, Janelle Sharkey, Hollie J Pegram, Sally M Amos, Mark J Smyth and Michael H Kershaw

    Citation: Journal of Translational Medicine 2010 8:42

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  47. Content type: Research

    Anti-IL-21R antibodies are potential therapeutics for the treatment of autoimmune diseases. This study evaluated correlations between the pharmacodynamic (PD) activity, pharmacokinetics, and anti-product antib...

    Authors: Yulia Vugmeyster, Scott Allen, Pamela Szklut, Andrea Bree, Mark Ryan, Margery Ma, Vikki Spaulding, Deborah Young, Heath Guay, Laird Bloom, Michael W Leach, Margot O'Toole and Karissa Adkins

    Citation: Journal of Translational Medicine 2010 8:41

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