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Immunobiology and immunotherapy

Section edited by Alessandra Cesano

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. Content type: Research

    Clinical trials of immunologic therapies provide opportunities to study the cellular and molecular effects of those therapies and may permit identification of biomarkers of response. When the trials are perfor...

    Authors: Walter C Olson, Mark E Smolkin, Erin M Farris, Robyn J Fink, Andrea R Czarkowski, Jonathan H Fink, Kimberly A Chianese-Bullock and Craig L Slingluff Jr

    Citation: Journal of Translational Medicine 2011 9:26

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  2. Content type: Review

    The Society for Immunotherapy of Cancer, SITC (formerly the International Society for Biological Therapy of Cancer, iSBTc), aims to improve cancer patient outcomes by advancing the science, development and app...

    Authors: James M Balwit, Patrick Hwu, Walter J Urba and Francesco M Marincola

    Citation: Journal of Translational Medicine 2011 9:18

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  3. Content type: Review

    Developing new vaccination strategies and optimizing current vaccines through heterologous prime-boost carries the promise of integrating the benefits of different yet synergistic vectors. It has been widely t...

    Authors: Adrian Bot, Zhiyong Qiu, Raymond Wong, Mihail Obrocea and Kent A Smith

    Citation: Journal of Translational Medicine 2010 8:132

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  4. Content type: Commentary

    The International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) hosted a one-day symposium at the National Institutes of Health on September 3...

    Authors: Lisa H Butterfield, Mary L Disis, Samir N Khleif, James M Balwit and Francesco M Marincola

    Citation: Journal of Translational Medicine 2010 8:130

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  5. Content type: Research

    Cytokine-induced killer (CIK) cells are typically differentiated in vitro with interferon (IFN)-γ and αCD3 monoclonal antibodies (mAb), followed by the repeated provision of interleukin (IL)-2. It is presently un...

    Authors: Giuseppina Bonanno, Paola Iudicone, Andrea Mariotti, Annabella Procoli, Annino Pandolfi, Daniela Fioravanti, Maria Corallo, Alessandro Perillo, Giovanni Scambia, Luca Pierelli and Sergio Rutella

    Citation: Journal of Translational Medicine 2010 8:129

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  6. Content type: Research

    Recent preclinical adoptive immunotherapy studies in murine models prompt to employ "proper" rather than "as many as possible" antigen-specific T cells to gain better therapeutic results. Ideally, "proper" T c...

    Authors: Anna Merlo, Riccardo Turrini, Cristina Trento, Paola Zanovello, Riccardo Dolcetti and Antonio Rosato

    Citation: Journal of Translational Medicine 2010 8:121

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  7. Content type: Research

    DNA vaccines represent an attractive approach for cancer treatment by inducing active T cell and B cell immune responses to tumor antigens. Previous studies have shown that interleukin-13 receptor α2 chain (IL...

    Authors: Hideyuki Nakashima, Toshio Fujisawa, Syed R Husain and Raj K Puri

    Citation: Journal of Translational Medicine 2010 8:116

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  8. Content type: Research

    Pegylated granulocyte colony-stimulating factor (G-CSF; pegfilgrastim) is a longer-acting form of G-CSF, whose effects on dendritic cell (DC) and regulatory T cell (Treg) mobilization, and on the in vivo and ex v...

    Authors: Giuseppina Bonanno, Annabella Procoli, Andrea Mariotti, Maria Corallo, Alessandro Perillo, Silvio Danese, Raimondo De Cristofaro, Giovanni Scambia and Sergio Rutella

    Citation: Journal of Translational Medicine 2010 8:114

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  9. Content type: Methodology

    The complex data sets generated by higher-order polychromatic flow cytometry experiments are a challenge to analyze. Here we describe Exhaustive Expansion, a data analysis approach for deriving hundreds to tho...

    Authors: Janet C Siebert, Lian Wang, Daniel P Haley, Ann Romer, Bo Zheng, Wes Munsil, Kenton W Gregory and Edwin B Walker

    Citation: Journal of Translational Medicine 2010 8:106

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  10. Content type: Research

    Tumor immune responses are first generated and metastases often begin in tumor sentinel lymph nodes (TSLN). Therefore, it is important to promote tumor immunity within this microenvironment. Mifepristone (RU48...

    Authors: Claudia Raja Gabaglia, Alexandra DeLaney, Jennifer Gee, Ramesh Halder, Frank L Graham, Jack Gauldie, Eli E Sercarz and Todd A Braciak

    Citation: Journal of Translational Medicine 2010 8:98

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  11. Content type: Research

    Antigen-loaded dendritic cells (DC) are capable of priming naïve T cells and therefore represent an attractive adjuvant for vaccine development in anti-tumor immunotherapy. Numerous protocols have been describ...

    Authors: Maja Bürdek, Stefani Spranger, Susanne Wilde, Bernhard Frankenberger, Dolores J Schendel and Christiane Geiger

    Citation: Journal of Translational Medicine 2010 8:90

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  12. Content type: Research

    Several single center studies have provided evidence of immune activation and antitumor activity of therapeutic vaccination with dendritic cells (DC) in patients with metastatic melanoma. The efficacy of this ...

    Authors: Antoni Ribas, Luis H Camacho, Sun Min Lee, Evan M Hersh, Charles K Brown, Jon M Richards, Maria Jovie Rodriguez, Victor G Prieto, John A Glaspy, Denise K Oseguera, Jackie Hernandez, Arturo Villanueva, Bartosz Chmielowski, Peggie Mitsky, Nadège Bercovici, Ernesto Wasserman…

    Citation: Journal of Translational Medicine 2010 8:89

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  13. Content type: Research

    The tumor associated antigen (TAA) gp100 was one of the first identified and has been used in clinical trials to treat melanoma patients. However, the gp100 epitope peptide restricted to HLA-A*2402 has not bee...

    Authors: Toshiyuki Baba, Marimo Sato-Matsushita, Akira Kanamoto, Akihiko Itoh, Naoki Oyaizu, Yusuke Inoue, Yutaka Kawakami and Hideaki Tahara

    Citation: Journal of Translational Medicine 2010 8:84

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  14. Content type: Research

    The oncogene CDC25B phosphatase plays an important role in cancer cell growth. We have recently reported that patients with esophageal squamous cell carcinoma (ESCC) have significantly higher serum levels of C...

    Authors: Jun Dong, Bo-hang Zeng, Li-hua Xu, Jun-ye Wang, Man-Zhi Li, Mu-sheng Zeng and Wan-li Liu

    Citation: Journal of Translational Medicine 2010 8:81

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  15. Content type: Research

    Melanoma vaccines have not been optimized. Adjuvants are added to activate dendritic cells (DCs) and to induce a favourable immunologic milieu, however, little is known about their cellular and molecular effec...

    Authors: Jochen T Schaefer, James W Patterson, Donna H Deacon, Mark E Smolkin, Gina R Petroni, Emily M Jackson and Craig L Slingluff Jr

    Citation: Journal of Translational Medicine 2010 8:79

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  16. Content type: Research

    High-dose interferon-alpha 2b (IFN-α 2b) is the only approved systemic therapy in the United States for the adjuvant treatment of melanoma. The study objective was to explore the immunomodulatory mechanism of ...

    Authors: Paolo A Ascierto, Maria Napolitano, Egidio Celentano, Ester Simeone, Giusy Gentilcore, Antonio Daponte, Mariaelena Capone, Corrado Caracò, Rosa Calemma, Gerardo Beneduce, Margherita Cerrone, Vincenzo De Rosa, Giuseppe Palmieri, Giuseppe Castello, John M Kirkwood, Francesco M Marincola…

    Citation: Journal of Translational Medicine 2010 8:76

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  17. Content type: Research

    IMP321 is a recombinant soluble LAG-3Ig fusion protein that binds to MHC class II with high avidity and mediates APC and then antigen-experienced memory CD8+ T cell activation. We report clinical and biological r...

    Authors: Chrystelle Brignone, Maya Gutierrez, Fawzia Mefti, Etienne Brain, Rosana Jarcau, Frédérique Cvitkovic, Nabil Bousetta, Jacques Medioni, Joseph Gligorov, Caroline Grygar, Manon Marcu and Frédéric Triebel

    Citation: Journal of Translational Medicine 2010 8:71

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  18. Content type: Research

    Adjuvant trastuzumab (Herceptin) treatment of breast cancer patients significantly improves their clinical outcome. Vaccination is an attractive alternative approach to provide HER-2/neu (Her2)-specific antibo...

    Authors: Håkan Norell, Isabel Poschke, Jehad Charo, Wei Z Wei, Courtney Erskine, Marie P Piechocki, Keith L Knutson, Jonas Bergh, Elisabet Lidbrink and Rolf Kiessling

    Citation: Journal of Translational Medicine 2010 8:53

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  19. Content type: Research

    In preparation for potential clinical development of Ab-01, an antagonistic antibody directed against the IL21R, studies were undertaken to address translational medicine needs that fall into four categories: ...

    Authors: Maya Arai, Sadhana Jain, Amy A Weaver, Andrew A Hill, Yongjing Guo, Andrea G Bree, Michael F Smith Jr, Scott W Allen, Edward R LaVallie, Deborah Young, Laird Bloom, Karissa Adkins and Margot O'Toole

    Citation: Journal of Translational Medicine 2010 8:51

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  20. Content type: Research

    Selective neutralization of the IL21/IL21R signaling pathway is a promising approach for the treatment of a variety of autoimmune diseases. Ab-01 is a human neutralizing anti-IL21R antibody. In order to ensure...

    Authors: Yongjing Guo, Andrew A Hill, Renee C Ramsey, Frederick W Immermann, Christopher Corcoran, Deborah Young, Edward R LaVallie, Mark Ryan, Theresa Bechard, Richard Pfeifer, Garvin Warner, Marcia Bologna, Laird Bloom and Margot O'Toole

    Citation: Journal of Translational Medicine 2010 8:50

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  21. Content type: Research

    T-cell immunodeficiency is a common feature in cancer patients, which may relate to initiation and development of tumor. Based on our previous finding, to further characterize the immune status, T cell prolife...

    Authors: Yangqiu Li, Suxia Geng, Qingsong Yin, Shaohua Chen, Lijian Yang, Xiuli Wu, Bo Li, Xin Du, Christian A Schmidt and Grzegorz K Przybylski

    Citation: Journal of Translational Medicine 2010 8:47

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  22. Content type: Research

    Combination immunotherapies can be effective against subcutaneous tumors in mice but the effect against orthotopic malignant disease is less well characterized. In particular, a combination of three agonist an...

    Authors: Jennifer A Westwood, Phillip K Darcy, Preethi Mayura Guru, Janelle Sharkey, Hollie J Pegram, Sally M Amos, Mark J Smyth and Michael H Kershaw

    Citation: Journal of Translational Medicine 2010 8:42

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  23. Content type: Research

    Anti-IL-21R antibodies are potential therapeutics for the treatment of autoimmune diseases. This study evaluated correlations between the pharmacodynamic (PD) activity, pharmacokinetics, and anti-product antib...

    Authors: Yulia Vugmeyster, Scott Allen, Pamela Szklut, Andrea Bree, Mark Ryan, Margery Ma, Vikki Spaulding, Deborah Young, Heath Guay, Laird Bloom, Michael W Leach, Margot O'Toole and Karissa Adkins

    Citation: Journal of Translational Medicine 2010 8:41

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  24. Content type: Research

    Several immunotherapeutic approaches rely on antigen-specific T-cells. Restrictions in the T-cell receptor (TCR) repertoire were reported as indicator of anti-tumor cytotoxic T-lymphocyte (CTL) response in var...

    Authors: Sebastian Ochsenreither, Alberto Fusi, Susanne Wojtke, Antonia Busse, Natascha C Nüssler, Eckhard Thiel, Ulrich Keilholz and Dirk Nagorsen

    Citation: Journal of Translational Medicine 2010 8:35

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  25. Content type: Research

    Type-1 T cells are critical for effective anti-tumor immune responses. The recently discovered microRNAs (miRs) are a large family of small regulatory RNAs that control diverse aspects of cell function, includ...

    Authors: Kotaro Sasaki, Gary Kohanbash, Aki Hoji, Ryo Ueda, Heather A McDonald, Todd A Reinhart, Jeremy Martinson, Michael T Lotze, Francesco M Marincola, Ena Wang, Mitsugu Fujita and Hideho Okada

    Citation: Journal of Translational Medicine 2010 8:17

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  26. Content type: Research

    Although an abundance of evidence has indicated that tumor-associated macrophages (TAMs) are associated with a favorable prognosis in patients with colon cancer, it is still unknown how TAMs exert a protective...

    Authors: Qiang Zhou, Rui-Qing Peng, Xiao-Jun Wu, Qing Xia, Jing-Hui Hou, Ya Ding, Qi-Ming Zhou, Xing Zhang, Zhi-Zhong Pang, De-Sen Wan, Yi-Xin Zeng and Xiao-Shi Zhang

    Citation: Journal of Translational Medicine 2010 8:13

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  27. Content type: Research

    Glycoprotein-96, a non-polymorphic heat-shock protein, associates with intracellular peptides. Autologous tumor-derived heat shock protein-peptide complex 96 (HSPPC-96) can elicit potent tumor-specific T cell ...

    Authors: Omar Eton, Merrick I Ross, Mary Jo East, Paul F Mansfield, Nicholas Papadopoulos, Julie A Ellerhorst, Agop Y Bedikian and Jeffrey E Lee

    Citation: Journal of Translational Medicine 2010 8:9

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  28. Content type: Research

    Due to the lack of specific tumor antigens, the majority of tested cancer vaccines for renal cell carcinoma (RCC) are based on tumor cell lysate. The identification of the von Hippel-Lindau (VHL) gene mutations i...

    Authors: Osama E Rahma, Ed Ashtar, Ramy Ibrahim, Antoun Toubaji, Barry Gause, Vincent E Herrin, W Marston Linehan, Seth M Steinberg, Frank Grollman, George Grimes, Sarah A Bernstein, Jay A Berzofsky and Samir N Khleif

    Citation: Journal of Translational Medicine 2010 8:8

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  29. Content type: Research

    The conventional treatment protocol in high-intensity focused ultrasound (HIFU) therapy utilizes a dense-scan strategy to produce closely packed thermal lesions aiming at eradicating as much tumor mass as poss...

    Authors: Fang Liu, Zhenlin Hu, Lei Qiu, Chun Hui, Chao Li, Pei Zhong and Junping Zhang

    Citation: Journal of Translational Medicine 2010 8:7

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  30. Content type: Research

    Efficacy of cancer vaccines may be limited due to immune escape mechanisms like loss or mutation of target antigens. Here, we analyzed 10 HLA-A2 positive patients with acute myeloid leukemia (AML) for loss or ...

    Authors: Antonia Busse, Anne Letsch, Carmen Scheibenbogen, Anika Nonnenmacher, Sebastian Ochsenreither, Eckhard Thiel and Ulrich Keilholz

    Citation: Journal of Translational Medicine 2010 8:5

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  31. Content type: Research

    Dendritic cells (DCs) are often produced by granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) stimulation of monocytes. To improve the effectiveness of DC adoptive immune cance...

    Authors: Ping Jin, Tae Hee Han, Jiaqiang Ren, Stefanie Saunders, Ena Wang, Francesco M Marincola and David F Stroncek

    Citation: Journal of Translational Medicine 2010 8:4

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  32. Content type: Research

    Liposomal doxorubicin (Doxil) is a cytotoxic chemotherapy drug with a favorable hematologic toxicity profile. Its active drug, doxorubicin, has interesting immunomodulatory properties. Here, the effects of Dox...

    Authors: Ioannis Alagkiozidis, Andrea Facciabene, Carmine Carpenito, Fabian Benencia, Zdenka Jonak, Sarah Adams, Richard G Carroll, Phyllis A Gimotty, Rachel Hammond, Gwen-äel Danet-Desnoyers, Carl H June, Daniel J Powell Jr and George Coukos

    Citation: Journal of Translational Medicine 2009 7:104

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  33. Content type: Research

    CD40 activation of antigen presenting cells (APC) such as dendritic cells (DC) and B cells plays an important role in immunological licensing of T cell immunity. Agonist CD40 antibodies have been previously sh...

    Authors: Erica L Carpenter, Rosemarie Mick, Jens Rüter and Robert H Vonderheide

    Citation: Journal of Translational Medicine 2009 7:93

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