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Immunobiology and immunotherapy

Section edited by Alessandra Cesano

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. Content type: Research

    Systemic lupus erythematosus (SLE) is an autoimmune-mediated chronic inflammatory disease. Half of patients with SLE suffer from lupus nephritis, which is major cause of death in SLE. TNF-like weak inducer of ...

    Authors: Hong-Ki Min, Sung-Min Kim, Jin-Sil Park, Jae-Kyeong Byun, Jennifer Lee, Seung-Ki Kwok, Young-Woo Park, Mi-La Cho and Sung-Hwan Park

    Citation: Journal of Translational Medicine 2016 14:98

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  2. Content type: Research

    Natural Killer (NK) cell effector functions are dependent on phosphorylation of the mitogen-activated protein kinases (MAPK) pathway to produce an effective immune response for the clearance of target cells in...

    Authors: Teilah Kathryn Huth, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2016 14:97

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  3. Content type: Research

    An efficient strategy for programing dendritic cells (DCs) for cancer immunotherapy is the optimization of their maturation so that they can efficiently stimulate cancer-specific T cell responses. Interleukin ...

    Authors: Valérie Chabot, Laurence Martin, Daniel Meley, Luc Sensebé, Christophe Baron, Yvon Lebranchu, Frédéric Dehaut and Florence Velge-Roussel

    Citation: Journal of Translational Medicine 2016 14:93

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  4. Content type: Research

    Double-negative (DN) T cells could delay the onset and the progression of autoimmune diabetes, yet they were less efficient on reversing autoimmune diabetes. The aim of this study was to investigate whether th...

    Authors: Tianhui Liu, Min Cong, Guangyong Sun, Ping Wang, Yue Tian, Wen Shi, Xinmin Li, Hong You and Dong Zhang

    Citation: Journal of Translational Medicine 2016 14:57

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  5. Content type: Research

    Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA chall...

    Authors: Irma Mahmutovic Persson, Hamid Akbarshahi, Mandy Menzel, Angelica Brandelius and Lena Uller

    Citation: Journal of Translational Medicine 2016 14:52

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  6. Content type: Research

    Potent antitumor responses can be induced through cytokine immunotherapy. Interleukin (IL)-2 and granulocyte–macrophage colony-stimulating factor (GM-CSF) are among the most effective cytokines to induce tumo...

    Authors: Qian Wen, Wenjing Xiong, Jianchun He, Shimeng Zhang, Xialin Du, Sudong Liu, Juanjuan Wang, Mingqian Zhou and Li Ma

    Citation: Journal of Translational Medicine 2016 14:41

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  7. Content type: Research

    In vivo depletion of host T cells with antithymocyte globulin (ATG) is a common strategy for preventing graft-versus-host disease in allogeneic hematopoietic stem cell transplantation (HSCT). The total dose of...

    Authors: Jiangying Liu, Lan-Ping Xu, Zhilei Bian, Ying-Jun Chang, Yu Wang, Xiao-Hui Zhang and Xiao-Jun Huang

    Citation: Journal of Translational Medicine 2015 13:391

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  8. Content type: Research

    Impaired Toll-like receptor 2 (TLR2) function has been associated with the pathogenesis of atopic dermatitis (AD). However, there are only few studies reporting on the TLR2-induced immunological responses of ...

    Authors: Yangyang Yu, Yarui Zhang, Jie Zhang, Xia Dou, Hong Yang, Yong Shao, Kepeng Wang, Bo Yu, Wei Zhang and Hang Yung Alaster Lau

    Citation: Journal of Translational Medicine 2015 13:384

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  9. Content type: Research

    Autoimmune hemolytic anemia (AIHA), a life-threatening anemia with rapid onset, is caused by autoantibody directed to self red blood cells (RBCs). Currently, mechanisms underlying AIHA pathogenesis are largel...

    Authors: Xiangmao Bu, Tenglong Zhang, Chunhong Wang, Tao Ren and Zhenke Wen

    Citation: Journal of Translational Medicine 2015 13:381

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  10. Content type: Research

    Ipilimumab is an approved immunotherapy that has shown an overall survival benefit in patients with cutaneous metastatic melanoma in two phase III trials. As results of registrational trials might not answer a...

    Authors: Lisa Zimmer, Thomas K. Eigentler, Felix Kiecker, Jan Simon, Jochen Utikal, Peter Mohr, Carola Berking, Eckhart Kämpgen, Edgar Dippel, Rudolf Stadler, Axel Hauschild, Michael Fluck, Patrick Terheyden, Rainer Rompel, Carmen Loquai, Zeinab Assi…

    Citation: Journal of Translational Medicine 2015 13:351

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  11. Content type: Research

    Autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease are treated with TNF-alpha-blocking antibodies such as infliximab and adalimumab. A common side effect of therapeutic antibodies is...

    Authors: Arne Homann, Niels Röckendorf, Arno Kromminga, Andreas Frey and Uta Jappe

    Citation: Journal of Translational Medicine 2015 13:339

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  12. Content type: Research

    Trastuzumab is a humanized monoclonal antibody (mAb) currently used for the treatment of breast cancer (BC) patients with HER-2 overexpressing tumor subtype. Previous data reported the involvement of FcγRIIIA/...

    Authors: Silvia Boero, Anna Morabito, Barbara Banelli, Barbara Cardinali, Beatrice Dozin, Gianluigi Lunardi, Patrizia Piccioli, Sonia Lastraioli, Roberta Carosio, Sandra Salvi, Alessia Levaggi, Francesca Poggio, Alessia D’Alonzo, Massimo Romani, Lucia Del Mastro, Alessandro Poggi…

    Citation: Journal of Translational Medicine 2015 13:324

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    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:24

  13. Content type: Research

    Characterization of PD-L1 expression within clinically/radiologically negative but microscopically tumor positive sentinel lymph nodes (SLN) is important to our understanding of the relevance of this immune ch...

    Authors: Ahmad A. Tarhini, Haris Zahoor, Jennifer H. Yearley, Christopher Gibson, Zahra Rahman, Rachel Dubner, Uma N. M. Rao, Cindy Sander and John M. Kirkwood

    Citation: Journal of Translational Medicine 2015 13:319

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  14. Content type: Research

    Hepatitis B (HB) is an infectious disease with unfavorable consequence for patients and involved in chronic inflammation of liver. The present study aimed to investigate whether High-mobility group protein B (...

    Authors: JooYeon Jhun, SeungHoon Lee, HeeYeon Kim, Yang-Mi Her, Jae Kyeong Byun, Eun-Kyung Kim, Soon Kyu Lee, Mi-La Cho and Jong Young Choi

    Citation: Journal of Translational Medicine 2015 13:310

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  15. Content type: Research

    Several attempts to improve immune function in young children have been made and encouraging results have been collected with pidotimod (PDT), a synthetic dipeptide molecule that seems to have immunomodulatory...

    Authors: Susanna Esposito, Micaela Garziano, Veronica Rainone, Daria Trabattoni, Mara Biasin, Laura Senatore, Paola Marchisio, Marta Rossi, Nicola Principi and Mario Clerici

    Citation: Journal of Translational Medicine 2015 13:288

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  16. Content type: Research

    Bronchial smooth muscle cells (BSMCs) from severe asthmatics have been shown to overexpress the Th2-driving and asthma-associated cytokine IL-33. However, little is known regarding factors involved in BSMC pro...

    Authors: Jenny Calvén, Hamid Akbarshahi, Mandy Menzel, Cemil Korcan Ayata, Marco Idzko, Leif Bjermer and Lena Uller

    Citation: Journal of Translational Medicine 2015 13:281

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  17. Content type: Research

    Tapasin is a crucial component of the major histocompatibility (MHC) class I antigen presentation pathway. Defects in this pathway can lead to tumor immune evasion. The aim of this study was to test whether ta...

    Authors: Lena Sokol, Viktor H. Koelzer, Tilman T. Rau, Eva Karamitopoulou, Inti Zlobec and Alessandro Lugli

    Citation: Journal of Translational Medicine 2015 13:279

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  18. Content type: Research

    The transcription factor forkhead box P3 (Foxp3) is a master regulatory gene necessary for the development and function of CD4+CD25+ regulatory T cells (Tregs). Mesenchymal stem cells (MSC) have recently emerged ...

    Authors: Haizhi Qi, Guangshun Chen, Yaxun Huang, Zhongzhou Si and Jiequn Li

    Citation: Journal of Translational Medicine 2015 13:274

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  19. Content type: Review

    The complement mediators are the major effectors of the immune balance, which operates at the interface between the innate and adaptive immunity, and is vital for many immunoregulatory functions. Activation of...

    Authors: Mohammad Afzal Khan, Abdullah Mohammed Assiri and Dieter Clemens Broering

    Citation: Journal of Translational Medicine 2015 13:272

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  20. Content type: Research

    Foxp3+ T cells regulate inflammation and tumorigenesis. However, little is known about the role of different subsets of Foxp3+ T cells in malignant or tuberculous hydrothorax.

    Authors: Ying Tang, Li-Ping Peng, Gui-Xiang Qin, Jing-Ting Sun, Li-Jun Xu and Yan-Fang Jiang

    Citation: Journal of Translational Medicine 2015 13:268

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  21. Content type: Research

    Chronic fatigue syndrome (CFS) is considered as a neuroimmunological disease but the etiology and pathophysiology is poorly understood. Patients suffer from sustained exhaustion, cognitive impairment and an in...

    Authors: Madlen Löbel, Agnes Anna Mooslechner, Sandra Bauer, Sabrina Günther, Anne Letsch, Leif G Hanitsch, Patricia Grabowski, Christian Meisel, Hans-Dieter Volk and Carmen Scheibenbogen

    Citation: Journal of Translational Medicine 2015 13:264

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  22. Content type: Research

    The beneficial outcome associated with the use of proton pump inhibitors (PPIs) in idiopathic pulmonary fibrosis (IPF) has been reported in retrospective studies. To date, no prospective study has been conduct...

    Authors: Yohannes T Ghebremariam, John P Cooke, William Gerhart, Carol Griego, Jeremy B Brower, Melanie Doyle-Eisele, Benjamin C Moeller, Qingtao Zhou, Lawrence Ho, Joao de Andrade, Ganesh Raghu, Leif Peterson, Andreana Rivera and Glenn D Rosen

    Citation: Journal of Translational Medicine 2015 13:249

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  23. Content type: Research

    Monoclonal antibodies (mAb) that block programmed death (PD)-1 signaling pathway hold great potential as a novel cancer immunotherapy. Recent evidence suggests that combining with conventional, targeted or oth...

    Authors: Zhiqiang Guo, Haolin Wang, Fandong Meng, Jie Li and Shulan Zhang

    Citation: Journal of Translational Medicine 2015 13:247

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  24. Content type: Research

    Acute myeloid leukemia (AML) is an incurable disease with fatal infections or relapse being the main causes of death in most cases. In particular, the severe infections occurring in these patients before or du...

    Authors: Gerardo Musuraca, Serena De Matteis, Roberta Napolitano, Cristina Papayannidis, Viviana Guadagnuolo, Francesco Fabbri, Delia Cangini, Michela Ceccolini, Maria Benedetta Giannini, Alessandro Lucchesi, Sonia Ronconi, Paolo Mariotti, Paolo Savini, Monica Tani, Pier Paolo Fattori, Massimo Guidoboni…

    Citation: Journal of Translational Medicine 2015 13:229

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  25. Content type: Research

    An important portion of asthmatics do not respond to current therapies. Thus, the need for new therapeutic drugs is urgent. We have demonstrated a critical role for PARP in experimental asthma. Olaparib, a PAR...

    Authors: Mohamed A Ghonim, Kusma Pyakurel, Salome V Ibba, Amir A Al-Khami, Jeffrey Wang, Paulo Rodriguez, Hamada F Rady, Ali H El-Bahrawy, Matthew R Lammi, Moselhy S Mansy, Kamel Al-Ghareeb, Alistair Ramsay, Augusto Ochoa, Amarjit S Naura and A Hamid Boulares

    Citation: Journal of Translational Medicine 2015 13:225

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  26. Content type: Research

    Killer cell immunoglobulin-like receptors (KIRs) show extensive variation in genetic content and allelic polymorphi sms among different populations.

    Authors: Qiongxiu Zhou, Jue Wang, Zhi He, Xiaojuan Li, Song Mao, Shu Huang, Guohui Bian and Feng Ma

    Citation: Journal of Translational Medicine 2015 13:221

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  27. Content type: Research

    There are a number of studies regarding to the susceptibility of A20 SNPs in rheumatoid arthritis (RA); however, a few of these studies have shown an association between polymorphisms in the A20 gene and RA risk ...

    Authors: Lihua Zhu, Liang Wang, Xu Wang, Lingling Zhou, Ziwei Liao, Ling Xu, Huixia Wu, Jie Ren, Zhaoxia Li, Lijian Yang, Shaohua Chen, Bo Li, Xiuli Wu, Yi Zhou and Yangqiu Li

    Citation: Journal of Translational Medicine 2015 13:215

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  28. Content type: Research

    Osteonecrosis of the jaw (ONJ) is a rare but serious adverse drug effect linked to long-term and/or high-dose exposure to nitrogen-bisphosphonates (N-BP), the standard of care for the treatment of bone fragili...

    Authors: Shirin Kalyan, Jun Wang, Elgar Susanne Quabius, Jörn Huck, Jörg Wiltfang, John F Baines and Dieter Kabelitz

    Citation: Journal of Translational Medicine 2015 13:212

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  29. Content type: Research

    Locally advanced HER2-overexpressing breast cancer (BC) patients achieve a high rate of pathological complete responses (pCR) after neoadjuvant chemotherapy (NC). The apparently unaltered immune proficiency of...

    Authors: E Muraro, E Comaro, R Talamini, E Turchet, G Miolo, S Scalone, L Militello, D Lombardi, S Spazzapan, T Perin, S Massarut, D Crivellari, Riccardo Dolcetti and D Martorelli

    Citation: Journal of Translational Medicine 2015 13:204

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  30. Content type: Research

    Resistin is a pro-inflammatory adipokine that increases after brain injury (trauma, bleeding) and may initiate an inflammatory response. Resistin was found increased in deceased, brain dead organ donors (DBD) ...

    Authors: Rille Pullerits, Simona Oltean, Anne Flodén and Mihai Oltean

    Citation: Journal of Translational Medicine 2015 13:201

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  31. Content type: Research

    Most patients with multiple myeloma (MM) will relapse after an initial response and eventually succumb to their disease. This is due to the persistence of chemotherapy-resistant tumor cells in the patients’ bo...

    Authors: Sara Yousef, Johanna Heise, Nesrine Lajmi, Katrin Bartels, Nicolaus Kröger, Tim Luetkens and Djordje Atanackovic

    Citation: Journal of Translational Medicine 2015 13:197

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  32. Content type: Research

    Anti-glomerular basement membrane nephritis and Goodpasture syndrome result from autoantibody (Ab)-mediated destruction of kidney and lung. Ab target the noncollagenous 1 (NC1) domain of alpha3(IV) collagen, b...

    Authors: Inge M Worni-Schudel, Amy G Clark, Tiffany Chien, Kwan-Ki Hwang, Benny J Chen and Mary H Foster

    Citation: Journal of Translational Medicine 2015 13:185

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  33. Content type: Research

    NK cells contribute to tumour surveillance, inhibition of growth and dissemination by cytotoxicity, secretion of cytokines and interaction with immune cells. Their precise role in human breast cancer is unclea...

    Authors: Chandan Verma, Viriya Kaewkangsadan, Jennifer M Eremin, Gerard P Cowley, Mohammad Ilyas, Mohamed A El-Sheemy and Oleg Eremin

    Citation: Journal of Translational Medicine 2015 13:180

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  34. Content type: Research

    Anti-dsDNA antibodies play an important role in the pathogenesis of lupus nephritis (LN). Endoplasmic reticulum (ER) stress is a physical reaction under stressful condition and can cause inflammation when stim...

    Authors: Hui Zhang, Chunmei Zhao, Shuang Wang, Yuefang Huang, Hongyue Wang, Jijun Zhao and Niansheng Yang

    Citation: Journal of Translational Medicine 2015 13:178

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  35. Content type: Research

    Dendritic cells (DC) are currently implemented as immunotherapeutic strategy for the treatment of tumor patients based on their central role in the immune system. Despite good results were obtained in vitro an...

    Authors: Chiara Massa, Carolin Thomas, Ena Wang, Francesco Marincola and Barbara Seliger

    Citation: Journal of Translational Medicine 2015 13:175

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  36. Content type: Research

    Redirection of T lymphocytes against tumor antigens can induce dramatic regression of advanced stage malignancy. The use of bispecific antibodies (BsAbs) that bind both the T-cell receptor (TCR) and a target a...

    Authors: Katarzyna Urbanska, Rachel C Lynn, Caitlin Stashwick, Archana Thakur, Lawrence G Lum and Daniel J Powell

    Citation: Journal of Translational Medicine 2014 12:347

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  37. Content type: Research

    Nanobodies (Nbs) have proved their great value as therapeutic molecules and clinical diagnostic tools. Although the routine procedure to obtain Nbs is to immunize camels with antigens, it is unavailable to imm...

    Authors: Junrong Yan, Guanghui Li, Yonghong Hu, Weijun Ou and Yakun Wan

    Citation: Journal of Translational Medicine 2014 12:343

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  38. Content type: Research

    Matrix metalloproteinase-23 (MMP-23) can block the voltage-gated potassium channel Kv1.3, whose function is important for sustained Ca2+ signaling during T cell activation. MMP-23 may also alter T cell activity a...

    Authors: Duane Moogk, Ines Pires da Silva, Michelle W Ma, Erica B Friedman, Eleazar Vega-Saenz de Miera, Farbod Darvishian, Patrick Scanlon, Arianne Perez-Garcia, Anna C Pavlick, Nina Bhardwaj, Paul J Christos, Iman Osman and Michelle Krogsgaard

    Citation: Journal of Translational Medicine 2014 12:342

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  39. Content type: Review

    Even in the era of successful combination antiretroviral therapy (cART), co-infection of Hepatitis C virus (HCV) remains one of the leading causes of non-AIDS-related mortality and morbidity among HIV-positive...

    Authors: AW Wahid Ansari, Reinhold E Schmidt, Esaki M Shankar and Adeeba Kamarulzaman

    Citation: Journal of Translational Medicine 2014 12:341

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  40. Content type: Research

    Endometrial regenerative cells (ERCs) are mesenchymal-like stem cells that can be non-invasively obtained from menstrual blood and are easily grown /generated at a large scale without tumorigenesis. We previou...

    Authors: Yongcheng Lv, Xiaoxi Xu, Bai Zhang, Guangying Zhou, Hongyue Li, Caigan Du, Hongqiu Han and Hao Wang

    Citation: Journal of Translational Medicine 2014 12:344

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  41. Content type: Research

    GL261 cells are murine glioma cells that demonstrate proliferation, invasion, and angiogenesis when implanted in syngeneic C57BL/6 mice, providing a highly useful immunocompetent animal model of glioblastoma. ...

    Authors: Aaron J Clark, Michael Safaee, Taemin Oh, Michael E Ivan, Vamsi Parimi, Rintaro Hashizume, Tomoko Ozawa, Charles D James, Orin Bloch and Andrew T Parsa

    Citation: Journal of Translational Medicine 2014 12:345

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  42. Content type: Methodology

    Cytomegalovirus (CMV)-specific T cell infusion to immunocompromised patients following allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) is able to induce a successful anti-viral response. These c...

    Authors: Lorea Beloki, Miriam Ciaurriz, Cristina Mansilla, Amaya Zabalza, Estela Perez-Valderrama, Edward R Samuel, Mark W Lowdell, Natalia Ramirez and Eduardo Olavarria

    Citation: Journal of Translational Medicine 2014 12:317

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  43. Content type: Research

    Regulatory T cells (Tregs) and B cells (Bregs) play an important role in the development of lung cancer. The present study aimed to investigate the phenotype of circulating Tregs and Bregs in patients with lun...

    Authors: Jiebai Zhou, Zhihui Min, Ding Zhang, William Wang, Francesco Marincola and Xiangdong Wang

    Citation: Journal of Translational Medicine 2014 12:304

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  44. Content type: Research

    This study aimed to explore the role of apoptosis initiators, caspase-9, caspase-10, mitochondrial anti-viral signaling protein (MAVS), and interferon regulatory factor 7 (pIRF7), in patients with systemic lup...

    Authors: Yu-Jih Su, Tien-Tsai Cheng, Chung-Jen Chen, Wen-Neng Chang, Nai-Wen Tsai, Chia-Te Kung, Hung-Chen Wang, Wei-Che Lin, Chih-Cheng Huang, Ya-Ting Chang, Chih-Min Su, Yi-Fang Chiang, Ben-Chung Cheng, Yu-Jun Lin and Cheng-Hsien Lu

    Citation: Journal of Translational Medicine 2014 12:303

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  45. Content type: Research

    Natural killer (NK) cells are abundant in the liver and constitute a major innate immune component that contributes to immune-mediated liver injury. However, few studies have investigated the phenotypes and fu...

    Authors: Min Zhang, Fenglan Wang, Yutian Chong, Qiang Tai, Qiyi Zhao, Yubao Zheng, Liang Peng, Shumei Lin and Zhiliang Gao

    Citation: Journal of Translational Medicine 2014 12:308

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  46. Content type: Review

    The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2,...

    Authors: Marco Genua, Sergio Rutella, Carmen Correale and Silvio Danese

    Citation: Journal of Translational Medicine 2014 12:293

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  47. Content type: Research

    Novel molecules that specifically target human TNFα in rheumatoid arthritis pose problems for preclinical assessment of efficacy. In this study collagen antibody-induced arthritis (CAIA) has been induced in hu...

    Authors: Adrian Richard Moore, Sarah Allden, Tim Bourne, Maria C Denis, Ksanthi Kranidioti, Remi Okoye, Yannis Sotsios, Zofia Stencel, Alexander Vugler, Gillian Watt and Stevan Shaw

    Citation: Journal of Translational Medicine 2014 12:285

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  48. Content type: Research

    microRNAs (miRNAs) are emerging as key regulators of the immune system, but their role in CD8+ T cell differentiation is not well explored. Some evidence suggests that signals from cell surface receptors influ...

    Authors: Hilary M Sheppard, Daniel Verdon, Anna ES Brooks, Vaughan Feisst, Yu-Yu Joyce Ho, Natalie Lorenz, Vicky Fan, Nigel P Birch, Alicia Didsbury and P Rod Dunbar

    Citation: Journal of Translational Medicine 2014 12:292

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