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Immunobiology and Immunotherapy

Section edited by Alessandra Cesano

The Immunobiology and Immunotherapy section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Pedro Romero was the founding Section Editor.

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  1. The study of localized immune-related factors has proven beneficial for a variety of conditions, and one area of interest in the field of orthopaedics is the impact of implants and localized infections on immu...

    Authors: Nicole Prince, Julia A. Penatzer, Matthew J. Dietz and Jonathan W. Boyd
    Citation: Journal of Translational Medicine 2020 18:330
  2. To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells.

    Authors: Jooyeon Jhun, Hong Ki Min, Jaeyoon Ryu, Seon-Yeong Lee, Jun-Geol Ryu, Jeong Won Choi, Hyun Sik Na, Seung Yoon Lee, Yunju Jung, Sang-Jun Park, Myeong Soo Park, Bin Kwon, Geun Eog Ji, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2020 18:317
  3. Fibrinogen-like protein 1 (FGL1)—Lymphocyte activating gene 3 (LAG-3) pathway is a promising immunotherapeutic target and has synergistic effect with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1)...

    Authors: Mengzhou Guo, Feifei Yuan, Feng Qi, Jialei Sun, Qianwen Rao, Zhiying Zhao, Peixin Huang, Tingting Fang, Biwei Yang and Jinglin Xia
    Citation: Journal of Translational Medicine 2020 18:306
  4. Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their cl...

    Authors: Hyun Sik Na, Seon-yeong Lee, Hong Ki Min, Wan-je Park, Jung-hwan Lee, Ka-hee Cho, Shin-hee Hong, Dae-hoon Kim, Jooyeon Jhun, Jeong-Won Choi, Sung-Min Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2020 18:264
  5. Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansio...

    Authors: Adam Brufsky, Juan Luis Gomez Marti, Azadeh Nasrazadani and Michael T. Lotze
    Citation: Journal of Translational Medicine 2020 18:261
  6. Pools of overlapping synthetic peptides are routinely used for ex vivo monitoring of antigen-specific T-cell responses. However, it is rather unlikely that these peptides match those resulting from naturally p...

    Authors: Nina Körber, Uta Behrends, Ulrike Protzer and Tanja Bauer
    Citation: Journal of Translational Medicine 2020 18:242
  7. Fibrosis is the formation of excess connective tissue in an organ or tissue during a reparative or reactive process. Graft-versus-host disease (GvHD) is a medical complication of allogeneic tissue transplantat...

    Authors: Jaeyoon Ryu, Jooyeon Jhun, Min-Jung Park, Jin-ah Baek, Se-Young Kim, Keun-Hyung Cho, Jeong-Won Choi, Sung-Hwan Park, Jong Young Choi and Mi-La Cho
    Citation: Journal of Translational Medicine 2020 18:225
  8. During early pregnancy, tolerance of the semi-allogeneic fetus necessitates comprehensive modifications of the maternal immune system. How decidual CD8+T (CD8+dT) cells balance maternal tolerance of the fetus wit...

    Authors: Lu Liu, Xixi Huang, Chunfang Xu, Chunqin Chen, Weijie Zhao, Dajin Li, Liping Li, Li Wang and Meirong Du
    Citation: Journal of Translational Medicine 2020 18:221
  9. Previous studies have shown clinical relevance of programmed death-ligand 1 (PD-L1) and soluble PD-L1 (sPD-L1) in human cancers. However, still contradictory results exist. Our aim was evaluation of PD-L1-expr...

    Authors: Karolina Okła, Alicja Rajtak, Arkadiusz Czerwonka, Marcin Bobiński, Anna Wawruszak, Rafał Tarkowski, Wiesława Bednarek, Justyna Szumiło and Jan Kotarski
    Citation: Journal of Translational Medicine 2020 18:220

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:258

  10. Patients with critical illness due to infection with the 2019 coronavirus disease (COVID-19) show rapid disease progression to acute respiratory failure. The study aimed to screen the most useful predictive fa...

    Authors: Jingyuan Liu, Yao Liu, Pan Xiang, Lin Pu, Haofeng Xiong, Chuansheng Li, Ming Zhang, Jianbo Tan, Yanli Xu, Rui Song, Meihua Song, Lin Wang, Wei Zhang, Bing Han, Li Yang, Xiaojing Wang…
    Citation: Journal of Translational Medicine 2020 18:206
  11. Sjögren’s syndrome (SS) is an autoimmune disease mediated by lymphocytic infiltration into exocrine glands, resulting in progressive lacrimal and salivary destruction and dysfunctional glandular secretion. Met...

    Authors: Sun-Hee Hwang, Jin-Sil Park, SeungCheon Yang, Kyung-Ah Jung, JeongWon Choi, Seung-Ki Kwok, Sung-Hwan Park and Mi-La Cho
    Citation: Journal of Translational Medicine 2020 18:186
  12. In a randomized phase II trial conducted in patients with metastatic melanoma, patient-specific autologous dendritic cell vaccines (DCV) were associated with longer survival than autologous tumor cell vaccines...

    Authors: Gabriel I. Nistor and Robert O. Dillman
    Citation: Journal of Translational Medicine 2020 18:176
  13. The mechanisms underlying the therapeutic activity of interferon-β in multiple sclerosis are still not completely understood. In the present study, we evaluated the short and long-term effects of interferon-β ...

    Authors: Marco Chiarini, Ruggero Capra, Federico Serana, Diego Bertoli, Alessandra Sottini, Viviana Giustini, Cristina Scarpazza, Marco Rovaris, Valentina Torri Clerici, Diana Ferraro, Simonetta Galgani, Claudio Solaro, Marta Zaffira Conti, Andrea Visconti and Luisa Imberti
    Citation: Journal of Translational Medicine 2020 18:169
  14. Complement Regulatory Proteins (CRPs), especially CD55 primarily negate complement factor 3-mediated injuries and maintain tissue homeostasis during complement cascade activation. Complement activation and reg...

    Authors: Mohammad Afzal Khan, Talal Shamma, Shadab Kazmi, Abdullah Altuhami, Hala Abdalrahman Ahmed, Abdullah Mohammed Assiri and Dieter Clemens Broering
    Citation: Journal of Translational Medicine 2020 18:147
  15. Cancer Immunotherapy has recently emerged as a promising and effective modality to treat different malignancies. Antigenic profiling of cancer tissues and determination of any pre-existing immune responses to ...

    Authors: Afsheen Raza, Maysaloun Merhi, Varghese Philipose Inchakalody, Roopesh Krishnankutty, Allan Relecom, Shahab Uddin and Said Dermime
    Citation: Journal of Translational Medicine 2020 18:140
  16. Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by an alteration in airway epithelial cell functions including barrier function, wound repair mechanisms, mucociliary clearance. The mechanism...

    Authors: Emilie Bequignon, David Mangin, Justine Bécaud, Jennifer Pasquier, Christelle Angely, Mathieu Bottier, Estelle Escudier, Daniel Isabey, Marcel Filoche, Bruno Louis, Jean-François Papon and André Coste
    Citation: Journal of Translational Medicine 2020 18:136
  17. Transitional B cells (TrB cells) represent a crucial link between immature B cells in the bone marrow and mature peripheral B cells. Although TrB cells represent one of the regulatory B cell subpopulations in ...

    Authors: Yang Zhou, Ying Zhang, Jinming Han, Mengge Yang, Jie Zhu and Tao Jin
    Citation: Journal of Translational Medicine 2020 18:131
  18. PD-1 blocking agents, such as nivolumab, have demonstrated clear anti-tumor effects and clinical benefits in a subset of patients with advanced malignancies. Nonetheless, more efforts are needed to identify re...

    Authors: Mariaelena Capone, Federica Fratangelo, Diana Giannarelli, Claudia Sorrentino, Roberta Turiello, Serena Zanotta, Domenico Galati, Gabriele Madonna, Marilena Tuffanelli, Luigi Scarpato, Antonio M. Grimaldi, Assunta Esposito, Rosa Azzaro, Antonio Pinto, Ernesta Cavalcanti, Aldo Pinto…
    Citation: Journal of Translational Medicine 2020 18:121
  19. Lung adenocarcinoma (LUAD) is the most frequent subtype of lung cancer. The prognostic signature could be reliable to stratify LUAD patients according to risk, which helps the management of the systematic trea...

    Authors: Dina Guo, Mian Wang, Zhihong Shen and Jiaona Zhu
    Citation: Journal of Translational Medicine 2020 18:123
  20. Salmonella enterica serovar Typhi (S. Typhi) is a highly invasive bacterium that infects the human intestinal mucosa and causes ~ 11.9–20.6 million infections and ~ 130,000–223,000 deaths annually worldwide. Oral...

    Authors: Jayaum S. Booth, Eric Goldberg, Robin S. Barnes, Bruce D. Greenwald and Marcelo B. Sztein
    Citation: Journal of Translational Medicine 2020 18:102
  21. Macrophages are heterogenous phagocytic cells with an important role in the innate immunity. They are, also, significant contributors in the adaptive immune system. Macrophages are the most abundant immune cel...

    Authors: Mohamed Hamed Abdelaziz, Sayed F. Abdelwahab, Jie Wan, Wei Cai, Wang Huixuan, Cheng Jianjun, Kesavan Dinesh Kumar, Aparna Vasudevan, Ahmed Sadek, Zhaoliang Su, Shengjun Wang and Huaxi Xu
    Citation: Journal of Translational Medicine 2020 18:58
  22. Crohn’s disease (CD) is a multifactorial disease characterized by chronic intestinal inflammation. The increased visceral adiposity near the affected intestinal area, of which mesenteric adipose tissue (MAT) i...

    Authors: Francesca Aparecida Ramos da Silva, Lívia Bitencourt Pascoal, Isabella Dotti, Maria de Lourdes Setsuko Ayrizono, Daniel Aguilar, Bruno Lima Rodrigues, Montserrat Arroyes, Elena Ferrer-Picon, Marciane Milanski, Lício Augusto Velloso, João José Fagundes, Azucena Salas and Raquel Franco Leal
    Citation: Journal of Translational Medicine 2020 18:44
  23. Recently, involvement of IL-19, IL-20 and IL-24 has been reported in inflammatory diseases associated with tissue remodeling. However, their impact on the pathomechanism of coeliac disease (CD) is still comple...

    Authors: Réka Rokonay, Apor Veres-Székely, Beáta Szebeni, Domonkos Pap, Rita Lippai, Nóra J. Béres, Gábor Veres, Attila J. Szabó and Ádám Vannay
    Citation: Journal of Translational Medicine 2020 18:36
  24. We have previously shown that HCC patients and healthy subjects are equally responsive to a RNAdjuvant®, a novel TLR-7/8/RIG-I agonist based on noncoding RNA developed by CureVac, by an ex vivo evaluation. Howeve...

    Authors: Angela Mauriello, Carmen Manolio, Beatrice Cavalluzzo, Antonio Avallone, Marco Borrelli, Alessandro Morabito, Emanuele Iovine, Angela Chambery, Rosita Russo, Maria Lina Tornesello, Franco M. Buonaguro, Maria Tagliamonte and Luigi Buonaguro
    Citation: Journal of Translational Medicine 2020 18:34
  25. The inefficacy of standard therapeutic strategies for ovarian cancer is reflected by the enduring poor prognosis of this malignancy. Due to the potential for exquisite specificity, sensitivity and long-term me...

    Authors: Leonardo Mirandola, Maurizio Chiriva-Internati, Robert Bresalier, Lucia Piccotti, Fabio Grizzi and Francesco M. Marincola
    Citation: Journal of Translational Medicine 2019 17:424
  26. Inflammatory Bowel Disease (IBD) is a multifactorial chronic disease. Understanding only one aspect of IBD pathogenesis does not reflect the complex nature of IBD nor will it improve its clinical management. T...

    Authors: Manoj Kumar, Mathieu Garand and Souhaila Al Khodor
    Citation: Journal of Translational Medicine 2019 17:419
  27. Immunosuppression caused by tumorigenesis may promote tumor progress and invasion. Here, we investigated whether the characteristics of circulating T lymphocyte subtypes in patients with extensive small cell l...

    Authors: Ning An, Haoyi Wang, Wenxiao Jia, Wang Jing, Chao Liu, Hui Zhu and Jinming Yu
    Citation: Journal of Translational Medicine 2019 17:402
  28. RH1 is one of the most clinically important blood group antigens in the field of transfusion and in the prevention of fetal incompatibility. The molecular analysis and characterization of serologic weak D phen...

    Authors: Xu Zhang, Guiji Li, Zhuren Zhou, Chaopeng Shao, Xuying Huang, Lichun Li, Xiaofeng Li, Ying Liu, Hua Fan and Jianping Li
    Citation: Journal of Translational Medicine 2019 17:393
  29. Fatigue was reported as the most common any-grade adverse event (18.3%), and the most common grade 3 or higher immune-related adverse event (irAE) (0.89%) in patients receiving PD-1/PD-L1 checkpoint inhibitors...

    Authors: Alessio Cortellini, Maria G. Vitale, Federica De Galitiis, Francesca R. Di Pietro, Rossana Berardi, Mariangela Torniai, Michele De Tursi, Antonino Grassadonia, Pietro Di Marino, Daniele Santini, Tea Zeppola, Cecilia Anesi, Alain Gelibter, Mario Alberto Occhipinti, Andrea Botticelli, Paolo Marchetti…
    Citation: Journal of Translational Medicine 2019 17:376
  30. Autologous tolerogenic dendritic cells (tolDC) are a promising therapeutic strategy for inflammatory arthritis (IA) as they can regulate autoantigen-specific T cell responses. Here, we investigated two outstan...

    Authors: Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere and Catharien M. U. Hilkens
    Citation: Journal of Translational Medicine 2019 17:375
  31. Middle East Respiratory Syndrome Coronavirus (MERS-COV) is the main cause of lung and kidney infections in developing countries such as Saudi Arabia and South Korea. This infectious single-stranded, positive (...

    Authors: Muhammad Tahir ul Qamar, Saman Saleem, Usman Ali Ashfaq, Amna Bari, Farooq Anwar and Safar Alqahtani
    Citation: Journal of Translational Medicine 2019 17:362
  32. Exosomes are 50–150 nm endocytic vesicles secreted by almost all type of cells that carry bioactive molecules from host. These small vesicles are considered to be novel cross-talk circuits established by tumor...

    Authors: Chuling Li, Chuwei Li, Chunchun Zhi, Wenjun Liang, Xuan Wang, Xi Chen, Tangfeng Lv, Qin Shen, Yong Song, Dang Lin and Hongbing Liu
    Citation: Journal of Translational Medicine 2019 17:355
  33. At present, immune checkpoint inhibitors, such as pembrolizumab, are widely used in the therapy of advanced non-resectable melanoma, as they induce more durable responses than other available treatments. Howev...

    Authors: Neta Tsur, Yuri Kogan, Evgenia Avizov-Khodak, Désirée Vaeth, Nils Vogler, Jochen Utikal, Michal Lotem and Zvia Agur
    Citation: Journal of Translational Medicine 2019 17:338
  34. Medulloblastoma (MB), the most common pediatric brain cancer, presents with a poor prognosis in a subset of patients with high risk disease, or at recurrence, where current therapies are ineffective. Cord bloo...

    Authors: Allison B. Powell, Sridevi Yadavilli, Devin Saunders, Stacey Van Pelt, Elizabeth Chorvinsky, Rachel A. Burga, Shuroug Albihani, Patrick J. Hanley, Zhenhua Xu, Yanxin Pei, Eric S. Yvon, Eugene I. Hwang, Catherine M. Bollard, Javad Nazarian and Conrad Russell Y. Cruz
    Citation: Journal of Translational Medicine 2019 17:321
  35. Despite major advances in rheumatoid arthritis outcome, not all patients achieve remission, and there is still an unmet need for new therapeutic approaches. This study aimed at evaluating in a pre-clinical mur...

    Authors: Céline Coppard, Francis Bonnefoy, Dalil Hannani, Françoise Gabert, Olivier Manches, Joel Plumas, Sylvain Perruche and Laurence Chaperot
    Citation: Journal of Translational Medicine 2019 17:312
  36. Calcium oxalate (CaOx), the major constituent of most kidney stones, induces inflammatory infiltration and injures renal tubular cells. However, the role of γδT cells in CaOx-mediated kidney injury remains unc...

    Authors: Chao Zhu, Qing Liang, Yaqun Liu, Deliang Kong, Jie Zhang, Hu Wang, Kejia Wang and Zhiyong Guo
    Citation: Journal of Translational Medicine 2019 17:278
  37. ACAM2000, a thymidine kinase (TK)-positive strain of vaccinia virus, is the current smallpox vaccine in the US. Preclinical testing demonstrated potent oncolytic activity of ACAM2000 against several tumor type...

    Authors: Boris R. Minev, Elliot Lander, John F. Feller, Mark Berman, Bernadette M. Greenwood, Ivelina Minev, Antonio F. Santidrian, Duong Nguyen, Dobrin Draganov, Mehmet O. Killinc, Anna Vyalkova, Santosh Kesari, Edward McClay, Gabriel Carabulea, Francesco M. Marincola, Lisa H. Butterfield…
    Citation: Journal of Translational Medicine 2019 17:271
  38. Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disorder and represents the leading cause of food impaction. The pathogenesis of EoE is the result of an interplay between genetic, envi...

    Authors: Elena Cavalli, Andrea Brusaferro, Elena Sofia Pieri, Rita Cozzali, Edoardo Farinelli, Gian Luigi de’ Angelis and Susanna Esposito
    Citation: Journal of Translational Medicine 2019 17:262
  39. The pleiotropic cytokine, transforming growth factor (TGF)-β, and CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a critical role in actively suppressing antitumor immune responses. Evidence shows that TGF-β prod...

    Authors: Magdalena J. Polanczyk, Edwin Walker, Daniel Haley, Bella S. Guerrouahen and Emmanuel T. Akporiaye
    Citation: Journal of Translational Medicine 2019 17:219
  40. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are intracellular sensors of pathogens and molecules from damaged cells to regulate the inflammatory response in the innate immune system. ...

    Authors: Luo-Yi Wang, Xiao-Jing Sun, Min Chen and Ming-Hui Zhao
    Citation: Journal of Translational Medicine 2019 17:197
  41. Current syphilis tests cannot distinguish between active and past syphilis among patients with serofast rapid plasma reagin (RPR) titers. We investigated whether cytokine profiles might provide insight in the ...

    Authors: N. Kojima, J. C. Siebert, H. Maecker, Y. Rosenberg-Hasson, S. R. Leon, S. K. Vargas, K. A. Konda, C. F. Caceres and J. D. Klausner
    Citation: Journal of Translational Medicine 2019 17:196
  42. Gastric cancer (GC) remains a refractory cancer worldwide. Currently, exploring the differences of the immune status in GC patients with different subgroups might provide promising immunotherapeutic approaches...

    Authors: Xu Liu, Danhua Xu, Chen Huang, Yixian Guo, Shuchang Wang, Chunchao Zhu, Jia Xu, Zizhen Zhang, Yanying Shen, Wenyi Zhao and Gang Zhao
    Citation: Journal of Translational Medicine 2019 17:192
  43. Patients with X-linked agammaglobulinemia (XLA) are protected against invasive bacterial infections due to IgG replacement therapy, but are still at higher risk for mucosal infections of the gut and respirator...

    Authors: Jeroen D. Langereis, Joannes F. M. Jacobs, Marien I. de Jonge and Marcel van Deuren
    Citation: Journal of Translational Medicine 2019 17:174
  44. Helios is important for functional and phenotype stability of regulatory T cells (Tregs). However, the role of Helios in autoimmune diseases and its regulation remains unclear. This study aimed to investigate ...

    Authors: Yi Li, Shumei Yang, Zhibin Li, Huanyu Meng, Wanling Jin, Huan Yang and Weifan Yin
    Citation: Journal of Translational Medicine 2019 17:168
  45. The tumor-associated microenvironment plays important roles in tumor progression and drug resistance. However, systematic investigations of macrophage–tumor cell interactions to identify novel macrophage-relat...

    Authors: Xiaoqiang Sun, Xiaoping Liu, Mengxue Xia, Yongzhao Shao and Xiaohua Douglas Zhang
    Citation: Journal of Translational Medicine 2019 17:159
  46. The onset of chronic fatigue syndrome (CFS) has been shown to be associated with several immunological conditions such as infections or atopy. The aim of this study was to clarify the risk of chronic fatigue s...

    Authors: Shin-Yi Tsai, Hsuan-Ju Chen, Chi Chen, Chon-Fu Lio, Chien-Feng Kuo, Kam-Hang Leong, Yu-Ting Tina Wang, Tse-Yen Yang, Ching-Hui You and Wei-Sheng Wang
    Citation: Journal of Translational Medicine 2019 17:154
  47. Targeting new molecular pathways leading to Osteoporosis (OP) and Osteoarthritis (OA) is a hot topic for drug discovery. Clusterin (CLU) is a glycoprotein involved in inflammation, proliferation, cell death, n...

    Authors: S. Pucci, C. Greggi, C. Polidoro, M. C. Piro, M. Celi, M. Feola, E. Gasbarra, R. Iundusi, F. Mastrangeli, G. Novelli, A. Orlandi and U. Tarantino
    Citation: Journal of Translational Medicine 2019 17:118

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