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Immunobiology and immunotherapy

Section edited by Alessandra Cesano

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. RH1 is one of the most clinically important blood group antigens in the field of transfusion and in the prevention of fetal incompatibility. The molecular analysis and characterization of serologic weak D phen...

    Authors: Xu Zhang, Guiji Li, Zhuren Zhou, Chaopeng Shao, Xuying Huang, Lichun Li, Xiaofeng Li, Ying Liu, Hua Fan and Jianping Li
    Citation: Journal of Translational Medicine 2019 17:393
    Content type: Research Published on:

  2. Fatigue was reported as the most common any-grade adverse event (18.3%), and the most common grade 3 or higher immune-related adverse event (irAE) (0.89%) in patients receiving PD-1/PD-L1 checkpoint inhibitors...

    Authors: Alessio Cortellini, Maria G. Vitale, Federica De Galitiis, Francesca R. Di Pietro, Rossana Berardi, Mariangela Torniai, Michele De Tursi, Antonino Grassadonia, Pietro Di Marino, Daniele Santini, Tea Zeppola, Cecilia Anesi, Alain Gelibter, Mario Alberto Occhipinti, Andrea Botticelli, Paolo Marchetti…
    Citation: Journal of Translational Medicine 2019 17:376
    Content type: Research Published on:

  3. Autologous tolerogenic dendritic cells (tolDC) are a promising therapeutic strategy for inflammatory arthritis (IA) as they can regulate autoantigen-specific T cell responses. Here, we investigated two outstan...

    Authors: Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere and Catharien M. U. Hilkens
    Citation: Journal of Translational Medicine 2019 17:375
    Content type: Research Published on:

  4. Middle East Respiratory Syndrome Coronavirus (MERS-COV) is the main cause of lung and kidney infections in developing countries such as Saudi Arabia and South Korea. This infectious single-stranded, positive (...

    Authors: Muhammad Tahir ul Qamar, Saman Saleem, Usman Ali Ashfaq, Amna Bari, Farooq Anwar and Safar Alqahtani
    Citation: Journal of Translational Medicine 2019 17:362
    Content type: Research Published on:

  5. Exosomes are 50–150 nm endocytic vesicles secreted by almost all type of cells that carry bioactive molecules from host. These small vesicles are considered to be novel cross-talk circuits established by tumor...

    Authors: Chuling Li, Chuwei Li, Chunchun Zhi, Wenjun Liang, Xuan Wang, Xi Chen, Tangfeng Lv, Qin Shen, Yong Song, Dang Lin and Hongbing Liu
    Citation: Journal of Translational Medicine 2019 17:355
    Content type: Research Published on:

  6. At present, immune checkpoint inhibitors, such as pembrolizumab, are widely used in the therapy of advanced non-resectable melanoma, as they induce more durable responses than other available treatments. Howev...

    Authors: Neta Tsur, Yuri Kogan, Evgenia Avizov-Khodak, Désirée Vaeth, Nils Vogler, Jochen Utikal, Michal Lotem and Zvia Agur
    Citation: Journal of Translational Medicine 2019 17:338
    Content type: Research Published on:

  7. Medulloblastoma (MB), the most common pediatric brain cancer, presents with a poor prognosis in a subset of patients with high risk disease, or at recurrence, where current therapies are ineffective. Cord bloo...

    Authors: Allison B. Powell, Sridevi Yadavilli, Devin Saunders, Stacey Van Pelt, Elizabeth Chorvinsky, Rachel A. Burga, Shuroug Albihani, Patrick J. Hanley, Zhenhua Xu, Yanxin Pei, Eric S. Yvon, Eugene I. Hwang, Catherine M. Bollard, Javad Nazarian and Conrad Russell Y. Cruz
    Citation: Journal of Translational Medicine 2019 17:321
    Content type: Research Published on:

  8. Despite major advances in rheumatoid arthritis outcome, not all patients achieve remission, and there is still an unmet need for new therapeutic approaches. This study aimed at evaluating in a pre-clinical mur...

    Authors: Céline Coppard, Francis Bonnefoy, Dalil Hannani, Françoise Gabert, Olivier Manches, Joel Plumas, Sylvain Perruche and Laurence Chaperot
    Citation: Journal of Translational Medicine 2019 17:312
    Content type: Research Published on:

  10. Calcium oxalate (CaOx), the major constituent of most kidney stones, induces inflammatory infiltration and injures renal tubular cells. However, the role of γδT cells in CaOx-mediated kidney injury remains unc...

    Authors: Chao Zhu, Qing Liang, Yaqun Liu, Deliang Kong, Jie Zhang, Hu Wang, Kejia Wang and Zhiyong Guo
    Citation: Journal of Translational Medicine 2019 17:278
    Content type: Research Published on:

  11. ACAM2000, a thymidine kinase (TK)-positive strain of vaccinia virus, is the current smallpox vaccine in the US. Preclinical testing demonstrated potent oncolytic activity of ACAM2000 against several tumor type...

    Authors: Boris R. Minev, Elliot Lander, John F. Feller, Mark Berman, Bernadette M. Greenwood, Ivelina Minev, Antonio F. Santidrian, Duong Nguyen, Dobrin Draganov, Mehmet O. Killinc, Anna Vyalkova, Santosh Kesari, Edward McClay, Gabriel Carabulea, Francesco M. Marincola, Lisa H. Butterfield…
    Citation: Journal of Translational Medicine 2019 17:271
    Content type: Research Published on:

  12. Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disorder and represents the leading cause of food impaction. The pathogenesis of EoE is the result of an interplay between genetic, envi...

    Authors: Elena Cavalli, Andrea Brusaferro, Elena Sofia Pieri, Rita Cozzali, Edoardo Farinelli, Gian Luigi de’ Angelis and Susanna Esposito
    Citation: Journal of Translational Medicine 2019 17:262
    Content type: Review Published on:

  13. The pleiotropic cytokine, transforming growth factor (TGF)-β, and CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a critical role in actively suppressing antitumor immune responses. Evidence shows that TGF-β prod...

    Authors: Magdalena J. Polanczyk, Edwin Walker, Daniel Haley, Bella S. Guerrouahen and Emmanuel T. Akporiaye
    Citation: Journal of Translational Medicine 2019 17:219
    Content type: Research Published on:

  14. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are intracellular sensors of pathogens and molecules from damaged cells to regulate the inflammatory response in the innate immune system. ...

    Authors: Luo-Yi Wang, Xiao-Jing Sun, Min Chen and Ming-Hui Zhao
    Citation: Journal of Translational Medicine 2019 17:197
    Content type: Research Published on:

  15. Current syphilis tests cannot distinguish between active and past syphilis among patients with serofast rapid plasma reagin (RPR) titers. We investigated whether cytokine profiles might provide insight in the ...

    Authors: N. Kojima, J. C. Siebert, H. Maecker, Y. Rosenberg-Hasson, S. R. Leon, S. K. Vargas, K. A. Konda, C. F. Caceres and J. D. Klausner
    Citation: Journal of Translational Medicine 2019 17:196
    Content type: Research Published on:

  16. Gastric cancer (GC) remains a refractory cancer worldwide. Currently, exploring the differences of the immune status in GC patients with different subgroups might provide promising immunotherapeutic approaches...

    Authors: Xu Liu, Danhua Xu, Chen Huang, Yixian Guo, Shuchang Wang, Chunchao Zhu, Jia Xu, Zizhen Zhang, Yanying Shen, Wenyi Zhao and Gang Zhao
    Citation: Journal of Translational Medicine 2019 17:192
    Content type: Research Published on:

  18. Patients with X-linked agammaglobulinemia (XLA) are protected against invasive bacterial infections due to IgG replacement therapy, but are still at higher risk for mucosal infections of the gut and respirator...

    Authors: Jeroen D. Langereis, Joannes F. M. Jacobs, Marien I. de Jonge and Marcel van Deuren
    Citation: Journal of Translational Medicine 2019 17:174
    Content type: Research Published on:

  19. Helios is important for functional and phenotype stability of regulatory T cells (Tregs). However, the role of Helios in autoimmune diseases and its regulation remains unclear. This study aimed to investigate ...

    Authors: Yi Li, Shumei Yang, Zhibin Li, Huanyu Meng, Wanling Jin, Huan Yang and Weifan Yin
    Citation: Journal of Translational Medicine 2019 17:168
    Content type: Research Published on:

  20. The tumor-associated microenvironment plays important roles in tumor progression and drug resistance. However, systematic investigations of macrophage–tumor cell interactions to identify novel macrophage-relat...

    Authors: Xiaoqiang Sun, Xiaoping Liu, Mengxue Xia, Yongzhao Shao and Xiaohua Douglas Zhang
    Citation: Journal of Translational Medicine 2019 17:159
    Content type: Research Published on:

  21. The onset of chronic fatigue syndrome (CFS) has been shown to be associated with several immunological conditions such as infections or atopy. The aim of this study was to clarify the risk of chronic fatigue s...

    Authors: Shin-Yi Tsai, Hsuan-Ju Chen, Chi Chen, Chon-Fu Lio, Chien-Feng Kuo, Kam-Hang Leong, Yu-Ting Tina Wang, Tse-Yen Yang, Ching-Hui You and Wei-Sheng Wang
    Citation: Journal of Translational Medicine 2019 17:154
    Content type: Research Published on:

  22. Targeting new molecular pathways leading to Osteoporosis (OP) and Osteoarthritis (OA) is a hot topic for drug discovery. Clusterin (CLU) is a glycoprotein involved in inflammation, proliferation, cell death, n...

    Authors: S. Pucci, C. Greggi, C. Polidoro, M. C. Piro, M. Celi, M. Feola, E. Gasbarra, R. Iundusi, F. Mastrangeli, G. Novelli, A. Orlandi and U. Tarantino
    Citation: Journal of Translational Medicine 2019 17:118
    Content type: Research Published on:

  23. Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease characterized by upregulation of inflammatory cell death and osteoclastogenesis. Necrostatin (NST)-1s is a chemical inhibitor of recepto...

    Authors: Jooyeon Jhun, Seung Hoon Lee, Se-Young Kim, Jaeyoon Ryu, Ji Ye Kwon, Hyun Sik Na, KyoungAh Jung, Su-Jin Moon, Mi-La Cho and Jun-Ki Min
    Citation: Journal of Translational Medicine 2019 17:84
    Content type: Research Published on:

  24. The morbidity of nephrolithiasis is 2–3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis. The death of renal tubular epithelial cells (TECs) is an important p...

    Authors: Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao and Yinghao Sun
    Citation: Journal of Translational Medicine 2019 17:62
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:146

  25. In 1975, Milstein and Köhler revolutionized the medical world with the development of the hybridoma technique to produce monoclonal antibodies. Since then, monoclonal antibodies have entered almost every branc...

    Authors: Lien Van Hoecke and Kenny Roose
    Citation: Journal of Translational Medicine 2019 17:54
    Content type: Review Published on:

  26. Immunology research, particularly next generation sequencing (NGS) of the immune T-cell receptor β (TCRβ) repertoire, has advanced progression in several fields, including treatment of various cancers and auto...

    Authors: Shang-Gin Wu, Wenjing Pan, Hongna Liu, Miranda L. Byrne-Steele, Brittany Brown, Mollye Depinet, Xiaohong Hou, Jian Han and Song Li
    Citation: Journal of Translational Medicine 2019 17:47
    Content type: Research Published on:

  27. Acute myocardial infarction (AMI) is characterized by an inflammatory process in which T cell plays a key role. However, the profile of immune microenvironment in AMI is still uncertain. High-throughput sequen...

    Authors: Dan Li, Longgang Hu, Qing Liang, Cuijuan Zhang, Yunzhen Shi, Bin Wang and Kejia Wang
    Citation: Journal of Translational Medicine 2019 17:40
    Content type: Research Published on:

  28. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the presence of pathogenic autoantibodies associated with polyclonal B cell hyperreactivity. Previous study reported that ...

    Authors: Meiyu Zhang, Chengcheng Yao, Jun Cai, Shuai Liu, Xia-nan Liu, Yingying Chen, Shujun Wang, Ping Ji, Meng Pan, Zizhen Kang and Ying Wang
    Citation: Journal of Translational Medicine 2019 17:37
    Content type: Research Published on:

  29. Tissue expansion is a procedure that promotes skin regeneration by mechanical stretch. During the stress and relaxation cycle, the skin undergoes a repeated microtrauma which triggers an immune response leadin...

    Authors: Jianke Ding, Lei Lei, Shiqiang Liu, Yu Zhang, Zhou Yu, Yingjun Su and Xianjie Ma
    Citation: Journal of Translational Medicine 2019 17:36
    Content type: Research Published on:

  30. Spondyloarthritis (SpA) is chronic inflammatory arthritis, and interleukin (IL)-17 is crucial in SpA pathogenesis. Type 17 helper T (Th17) cells are one of major IL-17-secreting cells. Signal transducer and ac...

    Authors: Hong-Ki Min, JeongWon Choi, Seon-Yeong Lee, Hyeon-Beom Seo, KyungAh Jung, Hyun Sik Na, Jun-Geol Ryu, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2019 17:18
    Content type: Research Published on:

  31. we have recently shown that Tel-eVax, a genetic vaccine targeting dog telomerase (dTERT) and based on Adenovirus (Ad)/DNA Electro-Gene-Transfer (DNA–EGT) technology can induce strong immune response and increa...

    Authors: Joseph A. Impellizeri, Alessandra Gavazza, Eliana Greissworth, Anna Crispo, Maurizio Montella, Gennaro Ciliberto, George Lubas and Luigi Aurisicchio
    Citation: Journal of Translational Medicine 2018 16:349
    Content type: Research Published on:

  32. The overlapping symptoms and pathophysiological similarities between burn injury and chronic fatigue syndrome (CFS) are noteworthy. Thus, this study explores the possible association between burn injury and th...

    Authors: Shin-Yi Tsai, Cheng-Li Lin, Shou-Chuan Shih, Cheng-Wei Hsu, Kam-Hang Leong, Chien-Feng Kuo, Chon-Fu Lio, Yu-Tien Chen, Yan-Jiun Hung and Leiyu Shi
    Citation: Journal of Translational Medicine 2018 16:342
    Content type: Research Published on:

  33. Temporal lobe epilepsy (TLE) is a common and often refractory brain disease that is closely correlated with inflammation. Alpha-methyl-l-tryptophan (AMT) is recognized as a surrogate marker for epilepsy, characte...

    Authors: Yanli Wang, Yanling Wang, Ran Sun, Xingrao Wu, Xu Chu, Shuhu Zhou, Xibin Hu, Lingyun Gao and Qingxia Kong
    Citation: Journal of Translational Medicine 2018 16:337
    Content type: Research Published on:

  34. With the exception of genotoxic oncology drugs, first-in-human, Phase 1 clinical studies of investigational drugs have traditionally been conducted in healthy volunteers (HVs). The primary goal of these studie...

    Authors: Joyson J. Karakunnel, Nam Bui, Latha Palaniappan, Keith T. Schmidt, Kenneth W. Mahaffey, Briggs Morrison, William D. Figg and Shivaani Kummar
    Citation: Journal of Translational Medicine 2018 16:336
    Content type: Review Published on:

  35. Epicutaneous immunotherapy (EPIT) is a new way of allergen administration that has a high rate of adherence and safety. The aim of this manuscript is to review clinical trials on EPIT for respiratory and food ...

    Authors: Susanna Esposito, Chiara Isidori, Alessandra Pacitto, Cristina Salvatori, Laura Sensi, Franco Frati, Giuseppe Di Cara and Francesco Marcucci
    Citation: Journal of Translational Medicine 2018 16:329
    Content type: Review Published on:

  36. The clinical trials conducted at Chingleput India suggest that BCG fails to protect against tuberculosis (TB) in TB-endemic population. Recent studies advocate that non-tuberculous mycobacteria and latent Mycobac...

    Authors: Pradeep K. Rai, Sathi Babu Chodisetti, Sudeep K. Maurya, Sajid Nadeem, Weiguang Zeng, Ashok K. Janmeja, David C. Jackson and Javed N. Agrewala
    Citation: Journal of Translational Medicine 2018 16:279
    Content type: Research Published on:

  37. Interleukin (IL)-37 has emerged as a novel anti-inflammatory cytokine that play an immunosuppressive role in regulating inflammatory response. This study aimed to measure IL-37 levels in the plasma and periphe...

    Authors: Miao Feng, Min Kang, Feng He, Zonghui Xiao, Zhewei Liu, Hailan Yao and Jianxin Wu
    Citation: Journal of Translational Medicine 2018 16:277
    Content type: Research Published on:

  38. NLRP3 inflammasome is involved in the inflammatory responses during acute lung injury (ALI). RIP3 triggered NLRP3 inflammasome activation independent of necroptosis induction has recently been documented. In t...

    Authors: Jingxian Chen, Shuang Wang, Rong Fu, Mianjing Zhou, Tengyue Zhang, Wenxu Pan, Niansheng Yang and Yuefang Huang
    Citation: Journal of Translational Medicine 2018 16:233
    Content type: Research Published on:

  39. The use of checkpoint inhibitors (ipilimumab, pembrolizumab, nivolumab) has revolutionised the treatment of metastatic melanoma. However still more than the half the patients do not respond to single-agent imm...

    Authors: Angus G. Dalgleish, Satvinder Mudan and Alberto Fusi
    Citation: Journal of Translational Medicine 2018 16:227
    Content type: Research Published on:

  40. Interest in single-cell transcriptomic analysis is growing rapidly, especially for profiling rare or heterogeneous populations of cells. In almost all reported works investigators have used live cells, which i...

    Authors: Jinguo Chen, Foo Cheung, Rongye Shi, Huizhi Zhou and Wenrui Lu
    Citation: Journal of Translational Medicine 2018 16:198
    Content type: Methodology Published on:

  41. The TGFβ-signaling pathway plays an important role in the pathogenesis of colorectal cancer (CRC). Loss of function of several genes within this pathway, such as bone morphogenetic proteins (BMPs) have been se...

    Authors: Andrew J. Pellatt, Lila E. Mullany, Jennifer S. Herrick, Lori C. Sakoda, Roger K. Wolff, Wade S. Samowitz and Martha L. Slattery
    Citation: Journal of Translational Medicine 2018 16:191
    Content type: Research Published on:

  42. Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard the...

    Authors: Linda M. Liau, Keyoumars Ashkan, David D. Tran, Jian L. Campian, John E. Trusheim, Charles S. Cobbs, Jason A. Heth, Michael Salacz, Sarah Taylor, Stacy D. D’Andre, Fabio M. Iwamoto, Edward J. Dropcho, Yaron A. Moshel, Kevin A. Walter, Clement P. Pillainayagam, Robert Aiken…
    Citation: Journal of Translational Medicine 2018 16:142
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:179

  43. Ipilimumab is a licensed immunotherapy for metastatic melanoma patients and, in the US, as adjuvant treatment for high risk melanoma radically resected. The use of ipilimumab is associated with a typical but u...

    Authors: Sara Valpione, Sandro Pasquali, Luca Giovanni Campana, Luisa Piccin, Simone Mocellin, Jacopo Pigozzo and Vanna Chiarion-Sileni
    Citation: Journal of Translational Medicine 2018 16:94
    Content type: Research Published on:

  44. “Avoiding immune destruction” has recently been established as one of the hallmarks of cancer. The programmed cell death (PD)-1/programmed cell death-ligand (PD-L) 1 pathway is an important immunosuppression m...

    Authors: Yuka Asano, Shinichiro Kashiwagi, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira
    Citation: Journal of Translational Medicine 2018 16:87
    Content type: Research Published on:

  45. The aim of this study was to investigate the mechanisms of OX40L in regulating helper T (Th) cells differentiation through phosphoinositide 3-kinase (PI3K)/AKT and p38 mitogen-activated protein kinase signalin...

    Authors: Li Huang, Meijuan Wang, Yongdong Yan, Wenjing Gu, Xinxing Zhang, Jiahong Tan, Huiming Sun, Wei Ji and Zhengrong Chen
    Citation: Journal of Translational Medicine 2018 16:74
    Content type: Research Published on:

  46. Fibrinogen is a central player in the blood coagulation cascade and one of the most abundant plasma proteins. This glycoprotein also triggers important events (e.g., cell spreading, the respiratory burst and d...

    Authors: Tiziana Alberio, Greta Forlani, Marta Lualdi, Giovanna Tosi, Roberto S. Accolla and Mauro Fasano
    Citation: Journal of Translational Medicine 2018 16:64
    Content type: Research Published on:

  47. Shigellosis persists as a public health problem worldwide causing ~ 165,000 deaths every year, of which ~ 55,000 are in children less than 5 years of age. No vaccine against shigellosis is currently licensed. ...

    Authors: Franklin R. Toapanta, Paula J. Bernal, Karen L. Kotloff, Myron M. Levine and Marcelo B. Sztein
    Citation: Journal of Translational Medicine 2018 16:61
    Content type: Research Published on:

  48. Th17 cells and its effective cytokine IL-17A play an important role in the pathogenesis of abnormal immune responses in psoriasis. Notch1 signaling has been implicated in Th17 cell differentiation and function...

    Authors: Lei Ma, Haibo Xue, Ruiqun Qi, Yanqin Wang and Libing Yuan
    Citation: Journal of Translational Medicine 2018 16:59
    Content type: Research Published on:

  49. An altered gut microbiota balance is involved in the pathogenesis of inflammatory bowel disease (IBD), and several probiotic strains are used as dietary supplements to improve intestinal health. We evaluated t...

    Authors: Jin-Sil Park, JeongWon Choi, Ji Ye Kwon, Kyung-Ah Jung, Chul Woo Yang, Sung-Hwan Park and Mi-La Cho
    Citation: Journal of Translational Medicine 2018 16:37
    Content type: Research Published on:

  50. During infection with human cytomegalovirus (HCMV) several viral proteins occur on cell surfaces in high quantity. We thus pursue an HLA-independent approach for immunotherapy of HCMV using chimeric antigen re...

    Authors: Julia Proff, Charlotte U. Brey, Armin Ensser, Wolfgang Holter and Manfred Lehner
    Citation: Journal of Translational Medicine 2018 16:26
    Content type: Research Published on:
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