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Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

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  1. Content type: Research

    Accumulated evidence suggests that dysregulated expression of long non-coding RNAs (lncRNAs) may play a critical role in tumorigenesis and prognosis of cancer, indicating the potential utility of lncRNAs as ca...

    Authors: Meng Zhou, Maoni Guo, Dongfeng He, Xiaojun Wang, Yinqiu Cui, Haixiu Yang, Dapeng Hao and Jie Sun

    Citation: Journal of Translational Medicine 2015 13:231

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  2. Content type: Research

    SERPINA1 is the gene for alpha-1 antitrypsin (AAT), an acute phase protein with anti-protease and immunoregulatory activities. Mutations in SERPINA1 gene cause AAT deficiency and predispose individuals to earl...

    Authors: Nerea Matamala, Maria Teresa Martínez, Beatriz Lara, Laura Pérez, Irene Vázquez, Azucena Jimenez, Miguel Barquín, Ilaria Ferrarotti, Ignacio Blanco, Sabina Janciauskiene and Beatriz Martinez-Delgado

    Citation: Journal of Translational Medicine 2015 13:211

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  3. Content type: Research

    Clinical therapy for metastatic colorectal cancer (CRC) remains limited, especially when the tumor harbors a KRAS mutation. This study aimed to identify prognostic biomarkers in CRC that are accessible for the...

    Authors: Anne-France le Rolle, Thang K Chiu, Michael Fara, Jinru Shia, Zhaoshi Zeng, Martin R Weiser, Philip B Paty and Vi K Chiu

    Citation: Journal of Translational Medicine 2015 13:199

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  4. Content type: Review

    There is an emerging demand for the use of molecular profiling to facilitate biomarker identification and development, and to stratify patients for more efficient treatment decisions with reduced adverse effec...

    Authors: Jin-Qiu Chen, Lalage M Wakefield and David J Goldstein

    Citation: Journal of Translational Medicine 2015 13:182

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  5. Content type: Research

    The purpose of this study was to examine the expression of metabolism-related proteins according to metastatic site in metastatic breast cancer and to assess the implication of site-specific differential expre...

    Authors: Hye Min Kim, Woo Hee Jung and Ja Seung Koo

    Citation: Journal of Translational Medicine 2014 12:354

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  6. Content type: Research

    In end-stage heart failure (HF), the implantation of a left ventricular assist device (LVAD) is able to induce reverse remodeling. Cellular proteases, such as cathepsins, are involved in the progression of HF....

    Authors: Andrea D’Amico, Rosetta Ragusa, Raffaele Caruso, Tommaso Prescimone, Sandra Nonini, Manuela Cabiati, Silvia Del Ry, Maria Giovanna Trivella, Daniela Giannessi and Chiara Caselli

    Citation: Journal of Translational Medicine 2014 12:350

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  7. Content type: Research

    Many current therapies for metastatic castration-resistant prostate cancer (mCRPC) are aimed at AR signaling; however, resistance to these therapies is inevitable. To personalize CRPC therapy in an individual ...

    Authors: Edwin E Reyes, David J VanderWeele, Masis Isikbay, Ryan Duggan, Alexa Campanile, Walter M Stadler, Donald J Vander Griend and Russell Z Szmulewitz

    Citation: Journal of Translational Medicine 2014 12:313

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  8. Content type: Research

    Human replication factor C4 (RFC4) is involved in DNA replication as a clamp loader and is aberrantly regulated across a range of cancers. The current study aimed to investigate the function of RFC4 in colorec...

    Authors: Jun Xiang, Lekun Fang, Yanxin Luo, Zuli Yang, Yi Liao, Ji Cui, Meijin Huang, Zihuan Yang, Yan Huang, Xinjuan Fan, Huashe Wang, Lei Wang, Junsheng Peng and Jianping Wang

    Citation: Journal of Translational Medicine 2014 12:320

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  9. Content type: Research

    The role of miRNAs in familial breast cancer (fBC) is poorly investigated as also in the BRCA-like tumors. To identify a specific miRNA expression pattern which could allow a better fBC classification not only...

    Authors: Katia Danza, Simona De Summa, Brunella Pilato, Massimo Carella, Orazio Palumbo, Ondina Popescu, Angelo Paradiso, Rosamaria Pinto and Stefania Tommasi

    Citation: Journal of Translational Medicine 2014 12:319

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  10. Content type: Research

    Among genitourinary malignancies, bladder cancer (BCa) ranks second in both prevalence and cause of death. Biomarkers of BCa for diagnosis, prognosis and disease surveillance could potentially help prevent pro...

    Authors: Brian K McNeil, Maximiliano Sorbellini, Robert L Grubb III, Andrea B Apolo, Fabiola Cecchi, Gagani Athauda, Benjamin Cohen, Alessio Giubellino, Haley Simpson, Piyush K Agarwal, Jonathan Coleman, Robert H Getzenberg, George J Netto, Joanna Shih, W Marston Linehan, Peter A Pinto…

    Citation: Journal of Translational Medicine 2014 12:199

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  11. Content type: Research

    Pancreatic cancer and other pancreaticobiliary type periampullary adenocarcinomas have a dismal prognosis even after resection and neoadjuvant chemotherapy. Intestinal type periampullary adenocarcinomas genera...

    Authors: Jacob Elebro, Margareta Heby, Alexander Gaber, Björn Nodin, Liv Jonsson, Richard Fristedt, Mathias Uhlén, Karin Jirström and Jakob Eberhard

    Citation: Journal of Translational Medicine 2014 12:289

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  12. Content type: Research

    Glioblastoma (GBM) is the most common and lethal intracranial malignancy in adults, with dismal prognosis despite multimodal therapies. Tectonic family member 1 (TCTN1) is a protein involved in a diverse range...

    Authors: Delong Meng, Yuanyuan Chen, Yingjie Zhao, Jingkun Wang, Dapeng Yun, Song Yang, Juxiang Chen, Hongyan Chen and Daru Lu

    Citation: Journal of Translational Medicine 2014 12:288

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  13. Content type: Research

    The major cancer related mortality is caused by metastasis and invasion. It is important to identify genes regulating metastasis and invasion in order to curtail metastatic spread of cancer cells.

    Authors: Chih-Hao Chang, Tan-Chi Fan, Jyh-Cherng Yu, Guo-Shiou Liao, You-Chin Lin, Arthur Chun-Chieh Shih, Wen-Hsiung Li and Alice Lin-Tsing Yu

    Citation: Journal of Translational Medicine 2014 12:257

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  14. Content type: Research

    Human cystatin C (HCC) is a potential biomarker for tubular damage and impaired renal function. It is difficult to obtain efficient paired monoclonal antibodies against HCC with low molecular to meet the requi...

    Authors: Renren Jiang, Chao Xu, Xiaoli Zhou, Tianhao Wang and Gang Yao

    Citation: Journal of Translational Medicine 2014 12:205

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  15. Content type: Research

    Platinum-based chemotherapy improves survival among patients with non-small cell lung cancer (NSCLC), but the efficiency is limited due to resistance. In this study, we aimed to identify the expression of Auro...

    Authors: Jie Xu, Cai-feng Yue, Wei-hua Zhou, Yuan-min Qian, Yan Zhang, Shao-wu Wang, An-wen Liu and Quentin Liu

    Citation: Journal of Translational Medicine 2014 12:200

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  16. Content type: Research

    Toll-like receptor 4 (TLR4), a lipopolysaccharide (LPS) receptor complex signal-transducing molecule, plays a crucial role in sensing LPS from gram-negative bacteria. TLR4 signaling pathway activation by LPS p...

    Authors: Ashham Mansur, Luisa von Gruben, Aron F Popov, Maximilian Steinau, Ingo Bergmann, Daniel Ross, Michael Ghadimi, Tim Beissbarth, Martin Bauer and José Hinz

    Citation: Journal of Translational Medicine 2014 12:177

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  17. Content type: Methodology

    Overall cure rates in acute myeloid leukemia (AML) continue to range between 60-65% with disease relapse being a major cause of mortality. The PI3K-Akt-mTOR kinase pathway plays a vital role in pro-survival si...

    Authors: Himalee Sabnis, Heath L Bradley, Silvia T Bunting, Todd M Cooper and Kevin D Bunting

    Citation: Journal of Translational Medicine 2014 12:166

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  18. Content type: Research

    HER2 status assessment is a prerequisite for the establishment of an appropriate treatment strategy in gastric cancer. Gastric cancers are very heterogeneous and separate evaluations of gene amplification and ...

    Authors: Dominique Werner, Achim Battmann, Kristina Steinmetz, Tobin Jones, Tiffany Lamb, Michele Martinez, Hans-Michael Altmannsberger and Salah-Eddin Al-Batran

    Citation: Journal of Translational Medicine 2014 12:160

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  19. Content type: Research

    Lung adenocarcinoma is a heterogernous disease that creates challenges for classification and management. The purpose of this study is to identify specific miRNA markers closely associated with the survival of...

    Authors: Xuelian Li, Yunrui Shi, Zhihua Yin, Xiaoxia Xue and Baosen Zhou

    Citation: Journal of Translational Medicine 2014 12:159

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  20. Content type: Research

    Telomere dysfunction is important in carcinogenesis, and recently, stathmin and elongation factor 1α (EF1α) were reported to be up-regulated in telomere dysfunctional mice.

    Authors: Ei Yong Ahn, Jeong Eun Yoo, Hyungjin Rhee, Myung Soo Kim, Junjeong Choi, Jung Eun Ko, Jee San Lee and Young Nyun Park

    Citation: Journal of Translational Medicine 2014 12:154

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  21. Content type: Methodology

    Personalized cancer treatment relies on the accurate detection of actionable genomic aberrations in tumor cells. Circulating tumor cells (CTCs) could provide an alternative genetic resource for diagnosis; howe...

    Authors: Masaru Watanabe, Masakuni Serizawa, Takeshi Sawada, Kazuo Takeda, Toshiaki Takahashi, Nobuyuki Yamamoto, Fumiaki Koizumi and Yasuhiro Koh

    Citation: Journal of Translational Medicine 2014 12:143

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  22. Content type: Review

    In recent years, it is recognized that acquired immunity is controlled by regulatory T cell (Treg). Since fundamental pathophysiological changes of allergy are mainly caused by hyperresponsiveness of immune sy...

    Authors: Huiyun Zhang, Hui Kong, Xiaoning Zeng, Lianyi Guo, Xiaoyun Sun and Shaoheng He

    Citation: Journal of Translational Medicine 2014 12:125

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  23. Content type: Research

    Understanding the pathogenic mechanism of pancreatic cancer associated diabetes (PCDM) might help yield biomarkers for the early diagnosis of pancreatic cancer (PC) from population with new-onset diabetes. In ...

    Authors: Langping Tan, Xiao Ye, Yu Zhou, Min Yu, Zhiqiang Fu, Ruiwan Chen, Baoxiong Zhuang, Bing Zeng, Huilin Ye, Wenchao Gao, Qing Lin, Zhihua Li, Quanbo Zhou and Rufu Chen

    Citation: Journal of Translational Medicine 2014 12:92

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  24. Content type: Research

    The polymeric immunoglobulin receptor (PIGR) has been proposed to be a candidate prognostic biomarker in a few cancer forms, and one previous study reported that reduced PIGR expression signifies more aggressi...

    Authors: Richard Fristedt, Alexander Gaber, Charlotta Hedner, Björn Nodin, Mathias Uhlén, Jakob Eberhard and Karin Jirström

    Citation: Journal of Translational Medicine 2014 12:83

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  25. Content type: Research

    Yin Yang 1 (YY1) is a transcription factor that regulates diverse biological processes and increasing recognized to have important roles in carcinogenesis. The function and clinical significance of YY1 in gast...

    Authors: Wei Kang, Joanna HM Tong, Anthony WH Chan, Junhong Zhao, Yujuan Dong, Shiyan Wang, Weiqin Yang, Frankie MC Sin, Simon SM Ng, Jun Yu, Alfred SL Cheng and Ka Fai To

    Citation: Journal of Translational Medicine 2014 12:80

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  26. Content type: Research

    Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, binds and activates ErbB1 and ErbB4 homodimers. BTC was expressed in tumors and involved in tumor growth progression. CXCL8 (interleuki...

    Authors: Lin Shi, Lingyan Wang, Beibei Wang, Sanda Maria Cretoiu, Qun Wang, Xiangdong Wang and Chengshui Chen

    Citation: Journal of Translational Medicine 2014 12:70

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  27. Content type: Research

    There are diverse molecules present in blood plasma that regulate immune functions and also present a potential source of disease biomarkers and therapeutic targets. Genome-wide profiling has become a powerful...

    Authors: Prasong Khaenam, Darawan Rinchai, Matthew C Altman, Laurent Chiche, Surachat Buddhisa, Chidchamai Kewcharoenwong, Duangchan Suwannasaen, Michael Mason, Elizabeth Whalen, Scott Presnell, Wattanachai Susaengrat, Kimberly O’Brien, Quynh-Ahn Nguyen, Vivian Gersuk, Peter S Linsley, Ganjana Lertmemongkolchai…

    Citation: Journal of Translational Medicine 2014 12:65

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  28. Content type: Research

    Hypoxic pulmonary artery hypertension (PAH) as a severe pulmonary disease is characterized by changes of pulmonary vascular reconstruction. Mitochondrial ATP-sensitive potassium channel (mitoKATP) was considered ...

    Authors: Li Dong, Yuping Li, HongLing Hu, Lin Shi, Junjie Chen, Beibei Wang, Chaolei Chen, Haiping Zhu, Yunlei Li, Qiu Li, Liping Zhang and Chengshui Chen

    Citation: Journal of Translational Medicine 2014 12:39

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  29. Content type: Research

    The effects of berberine on the metastatic potential of lung cancer cells and its underlying mechanisms have not been fully elucidated. Since epithelial-to-mesenchymal transition is a cellular process associat...

    Authors: Hui-wei Qi, Ling-yan Xin, Xin Xu, Xian-xiu Ji and Li-hong Fan

    Citation: Journal of Translational Medicine 2014 12:22

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  30. Content type: Research

    E1694 tested GM2-KLH-QS21 vaccine versus high-dose interferon-α2b (HDI) as adjuvant therapy for operable stage IIB-III melanoma. We tested banked serum specimens from patients in the vaccine arm of E1694 for p...

    Authors: Ahmad A Tarhini, Yan Lin, Oladapo Yeku, William A LaFramboise, Madeeha Ashraf, Cindy Sander, Sandra Lee and John M Kirkwood

    Citation: Journal of Translational Medicine 2014 12:19

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  31. Content type: Research

    Golgi phosphoprotein 3 (GOLPH3) has been validated as a potent oncogene involved in the progression of many types of solid tumors, and its overexpression is associated with poor clinical outcome in many cancer...

    Authors: Zaozao Wang, Beihai Jiang, Lei Chen, Jiabo Di, Ming Cui, Maoxing Liu, Yiyuan Ma, Hong Yang, Jiadi Xing, Chenghai Zhang, Zhendan Yao, Nan Zhang, Bin Dong, Jiafu Ji and Xiangqian Su

    Citation: Journal of Translational Medicine 2014 12:15

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  32. Content type: Research

    Nasopharyngeal carcinoma (NPC) is a solid tumor of the head and neck. Multimodal therapy is highly effective when NPC is detected early. However, due to the location of the tumor and the absence of clinical si...

    Authors: Jordan L Plieskatt, Gabriel Rinaldi, Yanjung Feng, Paul H Levine, Samantha Easley, Elizabeth Martinez, Salman Hashmi, Nader Sadeghi, Paul J Brindley, Jeffrey M Bethony and Jason P Mulvenna

    Citation: Journal of Translational Medicine 2014 12:3

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  33. Content type: Research

    Hypermethylation in the promoter regions is associated with the suppression of gene expression and has been considered a potential molecular marker for several tumor types, including head and neck squamous cel...

    Authors: Marianna Marconato Rettori, Ana Carolina de Carvalho, Ana Luiza Bomfim Longo, Cleyton Zanardo de Oliveira, Luiz Paulo Kowalski, André Lopes Carvalho and André Luiz Vettore

    Citation: Journal of Translational Medicine 2013 11:316

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  34. Content type: Research

    We have previously demonstrated an aberrant overexpression of the microtubule-associated protein TPX2 in colon cancer using a genome-wide gene expression profiling analysis. Here, we aim to investigate its exp...

    Authors: Ping Wei, Nu Zhang, Ye Xu, Xinxiang Li, Debing Shi, Yuwei Wang, Dawei Li and Sanjun Cai

    Citation: Journal of Translational Medicine 2013 11:313

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  35. Content type: Research

    Early disease detection with a minimally invasive screening test will significantly increase effectiveness and decrease the cost of treatment. Here we propose a framework of a novel approach – Universal Screen...

    Authors: Kira S Sheinerman, Vladimir G Tsivinsky and Samuil R Umansky

    Citation: Journal of Translational Medicine 2013 11:304

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  36. Content type: Research

    INI1 (Integrase interactor 1), also known as SMARCB1, is the most studied subunit of chromatin remodelling complexes. Its role in colorectal tumorigenesis is not known.

    Authors: Massimo Pancione, Andrea Remo, Caterina Zanella, Lina Sabatino, Arturo Di Blasi, Carmelo Laudanna, Laura Astati, Michele Rocco, Delfina Bifano, Paolo Piacentini, Laura Pavan, Alberto Purgato, Filippo Greco, Alberto Talamini, Andrea Bonetti, Michele Ceccarelli…

    Citation: Journal of Translational Medicine 2013 11:297

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  37. Content type: Research

    The ability to forecast whether a wound will heal after closure without further debridement(s), would provide substantial benefits to patients with severe extremity trauma.

    Authors: Brett A Chromy, Angela Eldridge, Jonathan A Forsberg, Trevor S Brown, Benjamin C Kirkup, Crystal Jaing, Nicholas A Be, Eric Elster and Paul A Luciw

    Citation: Journal of Translational Medicine 2013 11:281

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  38. Content type: Research

    Steadily high melanoma mortality rates urge for the availability of novel biomarkers with a more personalized ability to predict melanoma clinical outcomes. Germline risk variants are promising candidates for ...

    Authors: Justin Rendleman, Shulian Shang, Christine Dominianni, Jerry F Shields, Patrick Scanlon, Christina Adaniel, Alexis Desrichard, Michelle Ma, Richard Shapiro, Russell Berman, Anna Pavlick, David Polsky, Yongzhao Shao, Iman Osman and Tomas Kirchhoff

    Citation: Journal of Translational Medicine 2013 11:279

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  39. Content type: Research

    Paxillin (PXN) has been found to be aberrantly regulated in various malignancies and involved in tumor growth and invasion. The clinicopathological and prognostic significance of PXN in gastric cancer is still...

    Authors: Dong-liang Chen, Zhi-qiang Wang, Chao Ren, Zhao-lei Zeng, De-shen Wang, Hui-yan Luo, Feng Wang, Miao-zhen Qiu, Long Bai, Dong-sheng Zhang, Feng-hua Wang, Yu-hong Li and Rui-hua Xu

    Citation: Journal of Translational Medicine 2013 11:277

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  40. Content type: Research

    Increasing evidence has suggested that dysregulation of certain microRNAs (miRNAs) may contribute to human disease including carcinogenesis and tumor metastasis in human. miR-124-3p is down-regulated in variou...

    Authors: Xianglai Xu, Shiqi Li, Yiwei Lin, Hong Chen, Zhenghui Hu, Yeqing Mao, Xin Xu, Jian Wu, Yi Zhu, Xiangyi Zheng, Jindan Luo and Liping Xie

    Citation: Journal of Translational Medicine 2013 11:276

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  41. Content type: Research

    Colorectal cancer (CRC) is the most common digestive system malignancy. The molecular events involved in the development and progression of CRC remain unclear. Recently, more and more evidences have showed tha...

    Authors: Limin Long, Guoqing Huang, Hongyi Zhu, Yonghong Guo, Youshuo Liu and Jirong Huo

    Citation: Journal of Translational Medicine 2013 11:275

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  42. Content type: Research

    The La-related protein 1 (LARP1) has been found to be a RNA binding protein and was related to spermatogenesis, embryogenesis and cell-cycle progression. The aim of this study was to investigate the prognostic...

    Authors: Chan Xie, Li Huang, Shibin Xie, Dongying Xie, Genlin Zhang, Peipei Wang, Liang Peng and Zhiliang Gao

    Citation: Journal of Translational Medicine 2013 11:272

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  43. Content type: Research

    Alcohol consumption is a major cause of liver disease in humans. The use and monitoring of biomarkers associated with early, pre-clinical stages of alcohol-induced liver disease (pre-ALD) could facilitate diag...

    Authors: Heng-Hong Li, Kathryn Doiron, Andrew D Patterson, Frank J Gonzalez and Albert J Fornace Jr

    Citation: Journal of Translational Medicine 2013 11:266

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  44. Content type: Research

    Atherosclerosis is the main cause of morbidity and mortality in Western countries and carotid plaque rupture is associated to acute events and responsible of 15-20% of all ischemic strokes. Several proteomics ...

    Authors: Silvia Rocchiccioli, Gualtiero Pelosi, Silvia Rosini, Michele Marconi, Federica Viglione, Lorenzo Citti, Mauro Ferrari, Maria Giovanna Trivella and Antonella Cecchettini

    Citation: Journal of Translational Medicine 2013 11:260

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  45. Content type: Research

    Matrix metalloproteinases can promote invasion and metastasis, which are very frequent in renal cell carcinoma even at the time of diagnosis. Knowing the reversion-inducing cysteine-rich protein with Kazal mot...

    Authors: Anja Rabien, Carsten Stephan, Ergin Kilic, Wilko Weichert, Glen Kristiansen, Kurt Miller, Klaus Jung and Andreas Erbersdobler

    Citation: Journal of Translational Medicine 2013 11:258

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  46. Content type: Research

    Although the potential of biomarkers to aid in early detection of colorectal cancer (CRC) is recognized and numerous biomarker candidates have been reported in the literature, to date only few molecular marker...

    Authors: Stine Buch Thorsen, Martin Lundberg, Andrea Villablanca, Sarah Louise T Christensen, Kirstine Christensen Belling, Birgitte Sander Nielsen, Mick Knowles, Nick Gee, Hans Jørgen Nielsen, Nils Brünner, Ib Jarle Christensen, Simon Fredriksson, Jan Stenvang and Erika Assarsson

    Citation: Journal of Translational Medicine 2013 11:253

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