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Disease Biomarkers

Section edited by Xiangdong Wang and Hao Fang

The Disease Biomarkers section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Featured articles

Microfluidic devices for neutrophil chemotaxis studies

Review | Wenjie Zhao et al

Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model

Research | Han Wang et al

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Research | Michael A. Kiebish et al

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  1. Lynch syndrome (LS) is a highly penetrant inherited cancer predisposition syndrome, characterized by autosomal dominant inheritance and germline mutations in DNA mismatch repair genes. Despite several genetic ...

    Authors: Amira Jaballah-Gabteni, Haifa Tounsi, Maria Kabbage, Yosr Hamdi, Sahar Elouej, Ines Ben Ayed, Mouna Medhioub, Moufida Mahmoudi, Hamza Dallali, Hamza Yaiche, Nadia Ben Jemii, Afifa Maaloul, Najla Mezghani, Sonia Abdelhak, Lamine Hamzaoui, Mousaddak Azzouz…
    Citation: Journal of Translational Medicine 2019 17:212
    Content type: Research Published on:

  2. Glioma is the most common primary malignant brain tumor in adults with a poor prognosis. ARL3 is a member of the ARF family, and plays a key role in ciliary function and lipid-modified protein trafficking. ARL...

    Authors: Yulin Wang, Weijiang Zhao, Xin Liu, Gefei Guan and Minghua Zhuang
    Citation: Journal of Translational Medicine 2019 17:210
    Content type: Research Published on:

  3. Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development of a minimally-invasive diagnosis, b...

    Authors: Berta Roman-Canal, Jordi Tarragona, Cristian Pablo Moiola, Sònia Gatius, Sarah Bonnin, Maria Ruiz-Miró, José Enrique Sierra, Maria Rufas, Esperanza González, José M. Porcel, Antonio Gil-Moreno, Juan M. Falcón-Pérez, Julia Ponomarenko, Xavier Matias-Guiu and Eva Colas
    Citation: Journal of Translational Medicine 2019 17:208
    Content type: Research Published on:

  4. Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is still a challenge to determine patients’ prognosis. We aim to identify new prognostic markers for resected HCC patients.

    Authors: Gui-Qi Zhu, Yi Yang, Er-Bao Chen, Biao Wang, Kun Xiao, Shi-Ming Shi, Zheng-Jun Zhou, Shao-Lai Zhou, Zheng Wang, Ying-Hong Shi, Jia Fan, Jian Zhou, Tian-Shu Liu and Zhi Dai
    Citation: Journal of Translational Medicine 2019 17:203
    Content type: Research Published on:

  5. Platelets not only contribute to hemostasis but also to the regulation of inflammatory reactions and cancer pathogenesis. We hypothesized that blood platelet count would be associated with systemic inflammatio...

    Authors: Juha P. Väyrynen, Sara A. Väyrynen, Päivi Sirniö, Ilkka Minkkinen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J. Karttunen, Anne Tuomisto and Markus J. Mäkinen
    Citation: Journal of Translational Medicine 2019 17:199
    Content type: Research Published on:

  6. Early diagnosis is critical to reduce the mortality caused by nasopharyngeal carcinoma (NPC). MicroRNAs (miRNAs) are dysregulated and play important roles in carcinogenesis. Therefore, this study aimed to iden...

    Authors: Wen Wen, Shi-Juan Mai, Huan-Xin Lin, Mei-Yin Zhang, Jia-Ling Huang, Xin Hua, Chao Lin, Zhi-Qing Long, Zi-Jian Lu, Xiao-Qing Sun, Sai-Lan Liu, Qi Yang, Qian Zhu, Hui-Yun Wang and Ling Guo
    Citation: Journal of Translational Medicine 2019 17:186
    Content type: Research Published on:

  7. SWATH-MS has emerged as the strategy of choice for biomarker discovery due to the proteome coverage achieved in acquisition and provision to re-interrogate the data. However, in quantitative analysis using SWA...

    Authors: Mythreyi Narasimhan, Sadhana Kannan, Aakash Chawade, Atanu Bhattacharjee and Rukmini Govekar
    Citation: Journal of Translational Medicine 2019 17:184
    Content type: Research Published on:

  8. Prostate cancer is an extremely heterogeneous disease. Despite being clinically similar, some tumours are more likely to recur after surgery compared to others. Distinguishing those that need adjuvant or salva...

    Authors: C. Hoey, M. Ahmed, A. Fotouhi Ghiam, D. Vesprini, X. Huang, K. Commisso, A. Commisso, J. Ray, E. Fokas, D. A. Loblaw, H. H. He and S. K. Liu
    Citation: Journal of Translational Medicine 2019 17:173
    Content type: Research Published on:

  9. Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment options. Progress towards new therapies requires validated disease biomarkers, but there is no consensus on which fluid-based me...

    Authors: William R. Swindell, Colin P. S. Kruse, Edward O. List, Darlene E. Berryman and John J. Kopchick
    Citation: Journal of Translational Medicine 2019 17:170
    Content type: Research Published on:

  10. Acute myeloid leukemia (AML) is a heterogeneous disease in terms of genetic basis, clinical, biological and prognostic, and is a malignant clonal disease of leukemia stem cells (LSCs). Nearly half of adult AML...

    Authors: Ying Song, Weilong Zhang, Xue He, Xiaoni Liu, Ping Yang, Jing Wang, Kai Hu, Weiyou Liu, Xiuru Zhang, Hongmei Jing and Xiaoliang Yuan
    Citation: Journal of Translational Medicine 2019 17:166
    Content type: Research Published on:

  11. Translational medicine (TM) is an emerging domain that aims to facilitate medical or biological advances efficiently from the scientist to the clinician. Central to the TM vision is to narrow the gap between b...

    Authors: Laura Bravo-Merodio, John A. Williams, Georgios V. Gkoutos and Animesh Acharjee
    Citation: Journal of Translational Medicine 2019 17:155
    Content type: Research Published on:

  12. The high mortality of patients with non-small cell lung cancer (NSCLC) emphasizes the necessity of identifying a robust and reliable prognostic signature for NSCLC patients. This study aimed to identify and va...

    Authors: Shuguang Zuo, Min Wei, Hailin Zhang, Anxian Chen, Junhua Wu, Jiwu Wei and Jie Dong
    Citation: Journal of Translational Medicine 2019 17:152
    Content type: Research Published on:

  13. The available prognostic scoring systems for severe acute pancreatitis (SAP) have limitations that restrict their clinical value. The aim of this study was to develop a simple model (score) that could rapidly ...

    Authors: Wandong Hong, Keith D. Lillemoe, Shuang Pan, Vincent Zimmer, Evangelos Kontopantelis, Simon Stock, Maddalena Zippi, Chao Wang and Mengtao Zhou
    Citation: Journal of Translational Medicine 2019 17:146
    Content type: Research Published on:

  14. The distant metastasis of cancer cells is a risk factor for tumor lethality and poor prognosis in non-small-cell lung carcinoma (NSCLC). Increased SOX9 expression has been associated with clinical stage and po...

    Authors: Jing-Qiang Huang, Fa-Kai Wei, Xiu-Li Xu, Shi-Xing Ye, Jun-Wei Song, Pei-Kun Ding, Jing Zhu, He-Feng Li, Xin-Ping Luo, Hui Gong, Li Su, Lin Yang and Li-Yun Gong
    Citation: Journal of Translational Medicine 2019 17:143
    Content type: Research Published on:

  15. Serum GP73 is a useful biomarker in assessing hepatic fibrosis degree. The aim of this study was to evaluate the predictive value of serum GP73 level for posthepatectomy short-term outcomes in hepatocellular c...

    Authors: Meng-yun Ke, Xiao-ning Wu, Yao Zhang, Saisai Wang, Yi Lv and Jian Dong
    Citation: Journal of Translational Medicine 2019 17:140
    Content type: Research Published on:

  16. Acute kidney injury (AKI) is a common complication of acute myocardial infarction (AMI), and is associated with adverse outcomes. The study aimed to identify a miRNA signature for the early diagnosis of post-A...

    Authors: Pei-Chun Fan, Chia-Chun Chen, Chen-Ching Peng, Chih-Hsiang Chang, Chia-Hung Yang, Chi Yang, Lichieh Julie Chu, Yung-Chang Chen, Chih-Wei Yang, Yu-Sun Chang and Pao-Hsien Chu
    Citation: Journal of Translational Medicine 2019 17:139
    Content type: Research Published on:

  17. While prostate cancer can often manifest as an indolent disease, the development of locally-advanced or metastatic disease can cause significant morbidity or mortality. Elucidation of molecular mechanisms cont...

    Authors: Aruz Mesci, Fabrice Lucien, Xiaoyong Huang, Eric H. Wang, David Shin, Michelle Meringer, Christianne Hoey, Jessica Ray, Paul C. Boutros, Hon S. Leong and Stanley K. Liu
    Citation: Journal of Translational Medicine 2019 17:125
    Content type: Research Published on:

  18. Noninvasive prenatal screening (NIPS) based on cell-free fetal DNA (cffDNA) has rapidly been applied into clinic. However, the reliability of this method largely depends on the concentration of cffDNA in the m...

    Authors: Ping Hu, Dong Liang, Yangyi Chen, Ying Lin, Fengchang Qiao, Hang Li, Ting Wang, Chunfang Peng, Donghong Luo, Hailiang Liu and Zhengfeng Xu
    Citation: Journal of Translational Medicine 2019 17:124
    Content type: Research Published on:

  19. Triple negative breast cancer (TNBC) has been classified as a disease subgroup defined by the lack of expression of estrogen and progesterone receptors as well as the absence of the human epidermal growth fact...

    Authors: Wijden Mahfoudh, Inchirah Bettaieb, Randa Ghedira, Kaouther Snoussi, Nadia Bouzid, Zahra Klayech, Sallouha Gabbouj, Yassmine Remadi, Elham Hassen, Noureddine Bouaouina and Abdelfateh Zakhama
    Citation: Journal of Translational Medicine 2019 17:123
    Content type: Research Published on:

  20. Previous studies have shown that zinc-finger CCHC-type containing 13 (ZCCHC13) is located in an imprinted gene cluster in the X-inactivation centre, but few published studies have provided evidence of its expr...

    Authors: Zhiming Li, Zhi Li, Linjun Wang, Chen Long, Zaozao Zheng and Xuan Zhuang
    Citation: Journal of Translational Medicine 2019 17:108
    Content type: Research Published on:

  21. Acute myeloid leukemia (AML) is a highly heterogeneous malignancy with various outcomes, and therefore needs better risk stratification tools to help select optimal therapeutic options.

    Authors: Huihui Zhang, Ninghan Zhang, Rong Wang, Tingting Shao, Yuan Feng, Yao Yao, Qingyun Wu, Shengyun Zhu, Jiang Cao, Huanxin Zhang, Zhenyu Li, Xuejiao Liu, Mingshan Niu and Kailin Xu
    Citation: Journal of Translational Medicine 2019 17:106
    Content type: Research Published on:

  22. Leukemia stem cell (LSC)-enriched genes have been shown to be highly prognostic in acute myeloid leukemia (AML). However, the prognostic value of tumor suppressor genes (TSGs) that are repressed early in LSC r...

    Authors: Zi-jun Xu, Ji-chun Ma, Jing-dong Zhou, Xiang-mei Wen, Dong-ming Yao, Wei Zhang, Run-bi Ji, De-hong Wu, Li-juan Tang, Zhao-qun Deng, Jun Qian and Jiang Lin
    Citation: Journal of Translational Medicine 2019 17:102
    Content type: Research Published on:

  23. Oral squamous cell carcinoma (OSCC) is a common oral and maxillofacial malignant tumor with high rates of metastasis and mortality. Circular RNAs (circRNAs), a type of non-coding RNA, are involved in the devel...

    Authors: Wen Su, Shuai Sun, Feng Wang, Yuehong Shen and Hongyu Yang
    Citation: Journal of Translational Medicine 2019 17:76
    Content type: Research Published on:

  24. Extracellular vesicles (EVs) are small membrane-bound vesicles which play an important role in cell-to-cell communication. Their molecular cargo analysis is presented as a new source for biomarker detection, a...

    Authors: N. García-Romero, R. Madurga, G. Rackov, I. Palacín-Aliana, R. Núñez-Torres, A. Asensi-Puig, J. Carrión-Navarro, S. Esteban-Rubio, H. Peinado, A. González-Neira, V. González-Rumayor, C. Belda-Iniesta and A. Ayuso-Sacido
    Citation: Journal of Translational Medicine 2019 17:75
    Content type: Methodology Published on:

  25. CEA, CYFRA21-1 and NSE are tumor markers used for monitoring the response to chemotherapy in advanced adenocarcinoma, squamous cell carcinoma and small-cell lung cancer, respectively. Their role in cancer immu...

    Authors: M. G. Dal Bello, R. A. Filiberti, A. Alama, A. M. Orengo, M. Mussap, S. Coco, I. Vanni, S. Boccardo, E. Rijavec, C. Genova, F. Biello, G. Barletta, G. Rossi, M. Tagliamento, C. Maggioni and F. Grossi
    Citation: Journal of Translational Medicine 2019 17:74
    Content type: Research Published on:

  26. Currently, pathological examination of gastroscopy biopsy specimens is the gold standard for gastric cancer (GC) diagnosis. However, it has a false-negative rate of 10–20% due to inaccurate sampling locations ...

    Authors: Haidan Yan, Meifeng Li, Longlong Cao, Haifeng Chen, Hungming Lai, Qingzhou Guan, Huxing Chen, Wenbin Zhou, Baotong Zheng, Zheng Guo and Chaohui Zheng
    Citation: Journal of Translational Medicine 2019 17:63
    Content type: Research Published on:

  27. Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) in the world. Emerging evidence has shown that urinary mRNAs may serve as early diagnostic and prognostic biomarkers of DKD...

    Authors: Le-Ting Zhou, Lin-Li Lv, Shen Qiu, Qing Yin, Zuo-Lin Li, Tao-Tao Tang, Li-Hua Ni, Ye Feng, Bin Wang, Kun-Ling Ma and Bi-Cheng Liu
    Citation: Journal of Translational Medicine 2019 17:59
    Content type: Research Published on:

  28. Inflammation and demyelination are the main processes in multiple sclerosis. Nevertheless, to date, blood biomarkers of inflammation are lacking. TWEAK, a transmembrane protein that belongs to the TNF ligand f...

    Authors: Adil Maarouf, Delphine Stephan, Marie-Pierre Ranjeva, Jean-Philippe Ranjeva, Jean Pelletier, Bertrand Audoin, Michel Khrestchatisky and Sophie Desplat-Jégo
    Citation: Journal of Translational Medicine 2019 17:51
    Content type: Research Published on:

  29. Recently, circular RNAs (circRNAs) have been reported to be microRNA sponges and play essential roles in cancer development. This study aimed to evaluate whether circulating circRNAs could be used as diagnosti...

    Authors: Xiao-Xia Liu, Yi-E Yang, Xiao Liu, Meng-Yu Zhang, Rui Li, Yun-Hong Yin and Yi-Qing Qu
    Citation: Journal of Translational Medicine 2019 17:50
    Content type: Research Published on:

  30. Although previous prevalence studies of DED were reported from some countries worldwide, national data are unavailable in China. We aimed to conduct an up-to-date national survey on the prevalence of DED in Ch...

    Authors: Donghui Yu, Qinglong Deng, Jiwei Wang, Xing Chang, Shuxiao Wang, Renren Yang, Jinming Yu and Jing Yu
    Citation: Journal of Translational Medicine 2019 17:46
    Content type: Research Published on:

  31. Circulating tumor cells (CTC) shows great prospect to realize precision medicine in cancer patients.

    Authors: Weiling He, Di Xu, Zhuo Wang, Hui Wu, Xianhong Xiang, Bing Tang, Wenting Jiang, Yongmei Cui, Han Wang, Neng Jiang, Yu Sun, Yangshan Chen, Shuhua Li, Minzhi Hou, Yang Zhang, Liantang Wang…
    Citation: Journal of Translational Medicine 2019 17:32
    Content type: Research Published on:

  32. Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression o...

    Authors: Yi Liu, Yizuo Song, Miaomiao Ye, Xiaoli Hu, Z. Peter Wang and Xueqiong Zhu
    Citation: Journal of Translational Medicine 2019 17:28
    Content type: Review Published on:

  33. Despite much progress in cancer research, its incidence and mortality continue to rise. A robust biomarker that would predict tumor behavior is highly desirable and could improve patient treatment and prognosis.

    Authors: Wai Hoong Chang, Donall Forde and Alvina G. Lai
    Citation: Journal of Translational Medicine 2019 17:14
    Content type: Research Published on:

  34. Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ens...

    Authors: Katharina Bröker, Robin Terzenbach, Frank Bentzien, Stefan Lüth and Werner Dammermann
    Citation: Journal of Translational Medicine 2019 17:6
    Content type: Methodology Published on:

  35. Neoadjuvant chemotherapy (NAC) has become the standard of care for resectable esophageal squamous cell carcinoma (ESCC) which is one of the most lethal cancers, to improve resectability and prognosis. On this ...

    Authors: Yukiko Niwa, Suguru Yamada, Fuminori Sonohara, Keisuke Kurimoto, Masamichi Hayashi, Mitsuru Tashiro, Naoki Iwata, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara and Yasuhiro Kodera
    Citation: Journal of Translational Medicine 2019 17:1
    Content type: Research Published on:

  36. Lung adenocarcinoma (LUAD), largely remains a primary cause of cancer-related death worldwide. The molecular mechanisms in LUAD metastasis have not been completely uncovered.

    Authors: Lifeng Li, Mengle Peng, Wenhua Xue, Zhirui Fan, Tian Wang, Jingyao Lian, Yunkai Zhai, Wenping Lian, Dongchun Qin and Jie Zhao
    Citation: Journal of Translational Medicine 2018 16:372
    Content type: Research Published on:

  37. Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with various clinical manifestations. MicroRNAs (miRNAs) and immunometabolism are recognized as key elements in SLE pathogenesis; howeve...

    Authors: Gangqiang Guo, Huijing Wang, Xinyu Shi, Lele Ye, Kai Wu, Kangmin Lin, Sisi Ye, Baoqing Li, Huidi Zhang, Qiaoai Lin, Shuang Ye, Xiangyang Xue and Chaosheng Chen
    Citation: Journal of Translational Medicine 2018 16:370
    Content type: Research Published on:

  38. Adenosine-to-inosine (A-to-I) RNA editing is catalyzed by adenosine deaminases acting on RNA (ADAR) enzymes. Recent evidence suggests that RNA editing of antizyme inhibitor 1 (AZIN1) RNA is emerging as a key epig...

    Authors: Yoshinaga Okugawa, Yuji Toiyama, Kunitoshi Shigeyasu, Akira Yamamoto, Tsunehiko Shigemori, Chengzeng Yin, Takashi Ichikawa, Hiromi Yasuda, Hiroyuki Fujikawa, Shigeyuki Yoshiyama, Junichiro Hiro, Masaki Ohi, Toshimitsu Araki, Masato Kusunoki and Ajay Goel
    Citation: Journal of Translational Medicine 2018 16:366
    Content type: Research Published on:

  39. Immunoglobulin A (IgA) and IgG are major components in human intestinal mucosal surface and sera, and IgA- or IgG-coated bacteria play a vital role in the intestinal homeostasis. However, the correlation of Ig...

    Authors: Ritian Lin, Hongwei Chen, Weigang Shu, Mingming Sun, Leilei Fang, Yanhong Shi, Zhi Pang, Wei Wu and Zhanju Liu
    Citation: Journal of Translational Medicine 2018 16:359
    Content type: Research Published on:

  40. The androgen receptor (AR) is expressed in the majority of breast cancers and across the main breast cancer subtypes. Despite the high frequency of AR expression in breast cancer its appraisal remains controve...

    Authors: Monika Pizon, Daniel Lux, Ulrich Pachmann, Katharina Pachmann and Dorothea Schott
    Citation: Journal of Translational Medicine 2018 16:356
    Content type: Research Published on:

  41. Increasing evidences showed that the location of the primary tumor on the right (proximal) or left (distal) side of the colon have a prognostic/predictive value for colon cancer patients. However, the understa...

    Authors: Fabiana Tatangelo, Annabella Di Mauro, Giosuè Scognamiglio, Gabriella Aquino, Antonio Lettiero, Paolo Delrio, Antonio Avallone, Monica Cantile and Gerardo Botti
    Citation: Journal of Translational Medicine 2018 16:350
    Content type: Research Published on:

  42. In view of the limited knowledge of plasma biomarkers relating to cancer resistance to radiotherapy, we have set up screening, training and testing stages to investigate the microRNAs (miRNAs) expression profi...

    Authors: An-Lun Li, Tao-Sang Chung, Yao-Ning Chan, Chien-Lung Chen, Shih-Chieh Lin, Yun-Ru Chiang, Chen-Huan Lin, Chi-Ching Chen and Nianhan Ma
    Citation: Journal of Translational Medicine 2018 16:341
    Content type: Research Published on:

  43. Hepatocellular carcinoma is a malignant tumor with a highly invasive and metastatic phenotype, and the detection of potential indicators associated with its recurrence and metastasis after surgical resection i...

    Authors: Zheng Yu, Qifeng Ou, Fan Chen, Jiong Bi, Wen Li, Jieyi Ma, Rongchang Wang and Xiaohui Huang
    Citation: Journal of Translational Medicine 2018 16:327
    Content type: Research Published on:

  44. Chronic obstructive pulmonary disease (COPD) is a complex condition, whose diagnosis requires spirometric assessment. However, considering its heterogeneity, subjects with similar spirometric parameters do not...

    Authors: Tamara Pavić, Dario Dilber, Domagoj Kifer, Najda Selak, Toma Keser, Đivo Ljubičić, Andrea Vukić Dugac, Gordan Lauc, Lada Rumora and Olga Gornik
    Citation: Journal of Translational Medicine 2018 16:323
    Content type: Research Published on:

  45. Myalgic encephalomyelitis (ME) is a complex and debilitating disease that often initially presents with flu-like symptoms, accompanied by incapacitating fatigue. Currently, there are no objective biomarkers or...

    Authors: Kenny L. De Meirleir, Tatjana Mijatovic, Krishnamurthy Subramanian, Karen A. Schlauch and Vincent C. Lombardi
    Citation: Journal of Translational Medicine 2018 16:322
    Content type: Research Published on:

  46. The nucleotide oligomerization domain-like receptor subfamily C5 (NLRC5) is primarily expressed in the adaptive and innate immune systems. NLRC5 was recently discovered to regulate immunity and inflammatory re...

    Authors: Yusa Chen, Huihui Li, Chenggen Xiao, Xiangli Zeng, Xiangcheng Xiao, Qiaoling Zhou and Ping Xiao
    Citation: Journal of Translational Medicine 2018 16:317
    Content type: Research Published on:

  47. Uromodulin is specifically synthesized and secreted by kidney tubular epithelial cells. Studies on the association of serum uromodulin and outcomes of chronic kidney disease (CKD) are lacking. This study aimed...

    Authors: Li Lv, Jinwei Wang, Bixia Gao, Liang Wu, Fang Wang, Zhao Cui, Kevin He, Luxia Zhang, Min Chen and Ming-Hui Zhao
    Citation: Journal of Translational Medicine 2018 16:316
    Content type: Research Published on:

  48. Brain metastasis is an extremely serious sequela with a dismal prognosis in non-small cell lung cancer (NSCLC). The present study aimed to identify novel biomarkers and potential therapeutic targets for brain ...

    Authors: Fanrong Zhang, Lisha Ying, Jiaoyue Jin, Jianguo Feng, Kaiyan Chen, Minran Huang, Yingxue Wu, Herbert Yu and Dan Su
    Citation: Journal of Translational Medicine 2018 16:310
    Content type: Research Published on:

  49. Sarcomas are challenging to study because of their rarity and histomorphological complexity. PD1 and PD-L1 inhibitors showed a promising anti-tumor effect in solid tumors, where a relationship between PD-L1 ex...

    Authors: Hyung Kyu Park, Mingi Kim, Minjung Sung, Seung Eun Lee, Yu Jin Kim and Yoon-La Choi
    Citation: Journal of Translational Medicine 2018 16:303
    Content type: Research Published on:

  50. It was recently demonstrated that the size of cell-free DNA (cfDNA) fragments that originates from tumor cells are shorter than cfDNA fragments that originates from non-malignant cells. We investigated whether...

    Authors: Morten Lapin, Satu Oltedal, Kjersti Tjensvoll, Tove Buhl, Rune Smaaland, Herish Garresori, Milind Javle, Nils Idar Glenjen, Bente Kristin Abelseth, Bjørnar Gilje and Oddmund Nordgård
    Citation: Journal of Translational Medicine 2018 16:300
    Content type: Research Published on:
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