Skip to content

Advertisement

Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Page 3 of 6

  1. Content type: Research

    While the mortality rate is declining in the United States, the life expectancy gap among different population groups suggests a need to identify biomarkers to improve early identification of individuals at ri...

    Authors: Salman M. Tajuddin, Mike A. Nalls, Alan B. Zonderman and Michele K. Evans

    Citation: Journal of Translational Medicine 2017 15:208

    Published on:

  2. Content type: Research

    High expression of proviral integration site for Moloney murine leukemia virus-1 (PIM-1), a serine/threonine kinase, is associated with many cancers. The main purpose of this study were to investigate that the...

    Authors: Hui Cheng, Chongmei Huang, Xiaoqian Xu, Xiaoxia Hu, Shenglan Gong, Gusheng Tang, Xianmin Song, Weiping Zhang, Jianmin Wang, Li Chen and Jianmin Yang

    Citation: Journal of Translational Medicine 2017 15:179

    Published on:

  3. Content type: Research

    Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it ...

    Authors: Hui Wang, Christopher E. Barbieri, Jintang He, Yuqian Gao, Tujin Shi, Chaochao Wu, Athena A. Schepmoes, Thomas L. Fillmore, Sung-Suk Chae, Dennis Huang, Juan Miguel Mosquera, Wei-Jun Qian, Richard D. Smith, Sudhir Srivastava, Jacob Kagan, David G. Camp II…

    Citation: Journal of Translational Medicine 2017 15:175

    Published on:

  4. Content type: Research

    It is now recognized that asthma can present in different forms. Typically, asthma present with symptoms of wheeze, breathlessness and cough. Atypical forms of asthma such as cough variant asthma (CVA) or che...

    Authors: Chao Cao, Wen Li, Wen Hua, Fugui Yan, Hao Zhang, Huaqiong Huang, Yinghua Ying, Na Li, Fen Lan, Shaobin Wang, Xiao Chen, Jing Li, Jinkai Liu, Tianwen Lai, Zhengqiang Bao, Yuan Cao…

    Citation: Journal of Translational Medicine 2017 15:171

    Published on:

  5. Content type: Research

    Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to t...

    Authors: Whitney A. Sumner, William A. Stokes, Ayman Oweida, Kiersten L. Berggren, Jessica D. McDermott, David Raben, Diana Abbott, Bernard Jones, Gregory Gan and Sana D. Karam

    Citation: Journal of Translational Medicine 2017 15:168

    Published on:

  6. Content type: Research

    The purpose of this study was to explore gene copy number (GCN) variation of EGFR, HER2, c-MYC, and MET in patients with primary colorectal cancer (CRC).

    Authors: Yoonjin Kwak, Sumi Yun, Soo Kyung Nam, An Na Seo, Kyu Sang Lee, Eun Shin, Heung-Kwon Oh, Duck Woo Kim, Sung Bum Kang, Woo Ho Kim and Hye Seung Lee

    Citation: Journal of Translational Medicine 2017 15:167

    Published on:

  7. Content type: Research

    ETS2 is a downstream effector of the RAS/RAF/ERK pathway, which plays a critical role in the development of malignant tumor. However, the clinical impact of ETS2 expression in AML rema...

    Authors: Lin Fu, Huaping Fu, Qingyun Wu, Yifan Pang, Keman Xu, Lei Zhou, Jianlin Qiao, Xiaoyan Ke, Kailin Xu and Jinlong Shi

    Citation: Journal of Translational Medicine 2017 15:159

    Published on:

  8. Content type: Research

    Promoter methylation has emerged as a promising class of epigenetic biomarkers for diagnosis and prognosis of renal cell tumors (RCTs). Although differential gene promoter methylation patterns have been report...

    Authors: Ana Sílvia Pires-Luís, Pedro Costa-Pinheiro, Maria João Ferreira, Luís Antunes, Francisco Lobo, Jorge Oliveira, Rui Henrique and Carmen Jerónimo

    Citation: Journal of Translational Medicine 2017 15:149

    Published on:

  9. Content type: Research

    Influenza challenge trials are important for vaccine efficacy testing. Currently, disease severity is determined by self-reported scores to a list of symptoms which can be highly subjective. A more objective m...

    Authors: Julius Muller, Eneida Parizotto, Richard Antrobus, James Francis, Campbell Bunce, Amanda Stranks, Marshall Nichols, Micah McClain, Adrian V. S. Hill, Adaikalavan Ramasamy and Sarah C. Gilbert

    Citation: Journal of Translational Medicine 2017 15:134

    Published on:

  10. Content type: Research

    Oral lichen planus (OLP) is a T cell-mediated autoimmune disease. The aetiology and molecular mechanisms of OLP remain unclear. Human cytomegalovirus (HCMV) infection is a causal factor in the development of v...

    Authors: Meng Ding, Xiang Wang, Cheng Wang, Xiaoshuang Liu, Ke Zen, Wenmei Wang, Chen-Yu Zhang and Chunni Zhang

    Citation: Journal of Translational Medicine 2017 15:133

    Published on:

  11. Content type: Research

    The medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is characterized by non-healing exposed bone in the maxillofacial region. The pathogenesis of MRONJ (BP) is not ...

    Authors: Christian Gross, Manuel Weber, Kay Creutzburg, Patrick Möbius, Raimund Preidl, Kerstin Amann and Falk Wehrhan

    Citation: Journal of Translational Medicine 2017 15:128

    Published on:

  12. Content type: Research

    Discriminating between autoimmune pancreatitis (AIP), chronic pancreatitis (CP), and pancreatic ductal adenocarcinoma (PDAC) can be challenging. In this retrospective study, levels of serum and tissue cytokine...

    Authors: Sahar Ghassem-Zadeh, Matthias M. Gaida, Szilard Szanyi, Hans Acha-Orbea, Jean-Louis Frossard, Ulf Hinz, Thilo Hackert, Oliver Strobel and Klaus Felix

    Citation: Journal of Translational Medicine 2017 15:126

    Published on:

  13. Content type: Research

    Currently, several assays can diagnose acute dengue infection. However, none of these assays can predict the severity of the disease. Biomarkers that predicts the likelihood that a dengue patient will develop ...

    Authors: Yean K. Yong, Hong Y. Tan, Soe Hui Jen, Esaki M. Shankar, Santha K. Natkunam, Jameela Sathar, Rishya Manikam and Shamala D. Sekaran

    Citation: Journal of Translational Medicine 2017 15:121

    Published on:

  14. Content type: Review

    Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alteration...

    Authors: Ning Ren, Manar Atyah, Wan-Yong Chen and Chen-Hao Zhou

    Citation: Journal of Translational Medicine 2017 15:110

    Published on:

  15. Content type: Research

    The assessment of fibrosis and inflammatory activity is essential to identify patients with non-alcoholic fatty liver disease (NAFLD) at risk for progressive disease. Serum markers and ultrasound-based methods...

    Authors: Thomas Karlas, Lara Weise, Stephanie Kuhn, Felix Krenzien, Matthias Mehdorn, David Petroff, Nicolas Linder, Alexander Schaudinn, Harald Busse, Volker Keim, Johann Pratschke, Johannes Wiegand, Katrin Splith and Moritz Schmelzle

    Citation: Journal of Translational Medicine 2017 15:106

    Published on:

  16. Content type: Research

    Tuberculosis (TB) remains a significant global health concern and its diagnosis is challenging due to the limitations in the specificity and sensitivity of the current diagnostic tests. Exosomes are bioactive ...

    Authors: Shamila D. Alipoor, Esmaeil Mortaz, Payam Tabarsi, Parissa Farnia, Mehdi Mirsaeidi, Johan Garssen, Masoud Movassaghi and Ian M. Adcock

    Citation: Journal of Translational Medicine 2017 15:105

    Published on:

  17. Content type: Research

    Large numbers of CD8+ T cells were observed in atopic dermatitis (AD) skin, and monocytes from AD patients showed increased prostaglandin E2 production. However, little is known about the expression of substance ...

    Authors: Zenan Zhang, Wenjiao Zheng, Hua Xie, Ruonan Chai, Junling Wang, Huiyun Zhang and Shaoheng He

    Citation: Journal of Translational Medicine 2017 15:93

    Published on:

  18. Content type: Review

    Apoptosis plays an important role in the myocardial loss after acute myocardial infarction and participates in the process of subsequent left ventricular remodeling and development of symptomatic heart failure...

    Authors: Elena Teringova and Petr Tousek

    Citation: Journal of Translational Medicine 2017 15:87

    Published on:

  19. Content type: Research

    In previous work, we showed that serum-free amino acid (SFAA) profiles were different between kidney cancer patients and age and sex matched controls. The goals of the current study are to: (1) confirm our ini...

    Authors: Hyung-Ok Lee, Robert G. Uzzo, Debra Kister and Warren D. Kruger

    Citation: Journal of Translational Medicine 2017 15:72

    Published on:

  20. Content type: Research

    Previous studies have suggested PITX2, KCNN3 and ZFHX3 as atrial fibrillation (AF) susceptibility genes. Single common genetic polymorphisms of those genes have been linked with AF phenotypes and rhythm outcome o...

    Authors: Daniela Husser, Petra Büttner, Laura Ueberham, Borislav Dinov, Philipp Sommer, Arash Arya, Gerhard Hindricks and Andreas Bollmann

    Citation: Journal of Translational Medicine 2017 15:71

    Published on:

  21. Content type: Research

    A normal number of T-cell receptor excision circles (TRECs) and K-deleting recombination excision circles (KRECs) is considered a biomarker for adequate new T- and B-cell production. In newborns, detection of ...

    Authors: Marion Vaglio Tessitore, Alessandra Sottini, Aldo M. Roccaro, Claudia Ghidini, Simona Bernardi, Giovanni Martellosio, Federico Serana and Luisa Imberti

    Citation: Journal of Translational Medicine 2017 15:70

    Published on:

  22. Content type: Research

    The SAKK 19/05 trial investigated the safety and efficacy of the combined targeted therapy bevacizumab and erlotinib (BE) in unselected patients with advanced non-squamous non-small cell lung cancer (NSCLC). A...

    Authors: Florent Baty, Markus Joerger, Martin Früh, Dirk Klingbiel, Francesco Zappa and Martin Brutsche

    Citation: Journal of Translational Medicine 2017 15:66

    Published on:

  23. Content type: Research

    Lung cancer is the leading cause of cancer-related morbidity and mortality worldwide. Patients with chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), are exposed to a higher r...

    Authors: Hai-xing Zhu, Lin Shi, Yong Zhang, Yi-chun Zhu, Chun-xue Bai, Xiang-dong Wang and Jie-bai Zhou

    Citation: Journal of Translational Medicine 2017 15:65

    Published on:

  24. Content type: Research

    Renal fibrogenesis is associated with increased ECM remodeling and release of collagen fragments in urine in progressive renal disease. We investigated the diagnostic value of urinary collagen degradation prod...

    Authors: Ryanne S. Hijmans, Daniel Guldager Kring Rasmussen, Saleh Yazdani, Gerjan Navis, Harry van Goor, Morten Asser Karsdal, Federica Genovese and Jacob van den Born

    Citation: Journal of Translational Medicine 2017 15:63

    Published on:

  25. Content type: Research

    Inguinal orchiectomy is curative in 70–80% of clinical stage I testicular germ cell tumours (CS I TGCT). The identification of patients who are at low risk of relapse is critical to avoid unnecessary treatment...

    Authors: Miguel F. Sanmamed, E. Esteban, E. Uriol, R. Zarate, M. Capelan, C. Muriel, G. Crespo, J. P. Berros, P. Pardo-Coto, Q. Perez, C. Alvarez-Fernández, P. Jiménez Fonseca, M. Luque and A. Astudillo

    Citation: Journal of Translational Medicine 2017 15:62

    Published on:

  26. Content type: Research

    Investigations of activin family proteins as serum biomarkers for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). CFS/ME is a disease with complex, wide-ranging symptoms, featuring persistent fati...

    Authors: Brett A. Lidbury, Badia Kita, Donald P. Lewis, Susan Hayward, Helen Ludlow, Mark P. Hedger and David M. de Kretser

    Citation: Journal of Translational Medicine 2017 15:60

    Published on:

  27. Content type: Research

    Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive neurodegenerative disease caused by mutations in either the NPC1 or NPC2 genes. The diagnosis of NP-C remains challenging due to the non-specif...

    Authors: Isabel De Castro-Orós, Pilar Irún, Jorge Javier Cebolla, Victor Rodriguez-Sureda, Miguel Mallén, María Jesús Pueyo, Pilar Mozas, Carmen Dominguez and Miguel Pocoví

    Citation: Journal of Translational Medicine 2017 15:43

    Published on:

  28. Content type: Research

    The shift towards an earlier diagnosis of breast cancer (BC) highlights the need for biomarkers that would identify patients at risk for relapse and metastatic spread and indicate the potential value of additi...

    Authors: Amanda Psyrri, Konstantine T. Kalogeras, Ralph M. Wirtz, George Kouvatseas, Georgia Karayannopoulou, Anna Goussia, Flora Zagouri, Elke Veltrup, Eleni Timotheadou, Helen Gogas, Angelos Koutras, Georgios Lazaridis, Christos Christodoulou, George Pentheroudakis, Panagiota Economopoulou, Apostolos Laskarakis…

    Citation: Journal of Translational Medicine 2017 15:30

    Published on:

  29. Content type: Research

    Metabolic alterations play a role in the development of inflammatory myopathies (IMs). Herein, we have investigated through a multiplex assay whether proteins of energy metabolism could provide biomarkers of IMs.

    Authors: Fulvio Santacatterina, María Sánchez-Aragó, Marc Catalán-García, Glòria Garrabou, Cristina Nuñez de Arenas, Josep M. Grau, Francesc Cardellach and José M. Cuezva

    Citation: Journal of Translational Medicine 2017 15:29

    Published on:

  30. Content type: Research

    Due to the heterogeneity of cancer, identifying differentially methylated (DM) CpG sites between a set of cancer samples and a set of normal samples cannot tell us which patients have methylation aberrations i...

    Authors: Haidan Yan, Qingzhou Guan, Jun He, Yunqing Lin, Juan Zhang, Hongdong Li, Huaping Liu, Yunyan Gu, Zheng Guo and Fei He

    Citation: Journal of Translational Medicine 2017 15:26

    Published on:

  31. Content type: Research

    Maternal smoking during pregnancy results in an increased risk of low birth weight through perturbations in the utero-placental exchange. Epigenetics and mitochondrial function in fetal tissues might be molecular...

    Authors: Bram G. Janssen, Wilfried Gyselaers, Hyang-Min Byun, Harry A. Roels, Ann Cuypers, Andrea A. Baccarelli and Tim S. Nawrot

    Citation: Journal of Translational Medicine 2017 15:5

    Published on:

  32. Content type: Research

    Study of age related macular degeneration (AMD) has been hampered by lack of human models that represent the complexity of the disease. Here we have developed a human in vitro disease model of AMD to investiga...

    Authors: Nady Golestaneh, Yi Chu, Shuk Kei Cheng, Hong Cao, Eugenia Poliakov and Daniel M. Berinstein

    Citation: Journal of Translational Medicine 2016 14:344

    Published on:

  33. Content type: Commentary

    Earlier this year, we described an analysis of mitochondrial DNA (mtDNA) variants in myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) patients and healthy controls. We reported that there was no s...

    Authors: Maureen R. Hanson, Zhenglong Gu, Alon Keinan, Kaixiong Ye, Arnaud Germain and Paul Billing-Ross

    Citation: Journal of Translational Medicine 2016 14:342

    Published on:

  34. Content type: Research

    Conventional approaches to understand mechanisms underlying the development of pathological manifestations in ulcerative colitis (UC) mostly rely on identification of certain cell types and cytokines followed ...

    Authors: M. Föhlinger, P. Palamides, U. Mansmann, F. Beigel, M. Siebeck and R. Gropp

    Citation: Journal of Translational Medicine 2016 14:310

    Published on:

  35. Content type: Research

    Clinical ovulation induction induces blood estrogen (E2) in excess of physiological levels, which can hinder uterine receptivity. In contrast, progesterone produces the opposite clinical effect, suggesting that i...

    Authors: Guowu Chen, Aijie Xin, Yulin Liu, Changgen Shi, Junling Chen, Xiaofeng Tang, Ying Chen, Min Yu, Xiandong Peng, Lu Li and Xiaoxi Sun

    Citation: Journal of Translational Medicine 2016 14:303

    Published on:

  36. Content type: Meeting report

    The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The “1st International NTNU...

    Authors: Ana I. Robles, Karina Standahl Olsen, Dana W.T. Tsui, Vassilis Georgoulias, Jenette Creaney, Katalin Dobra, Mogens Vyberg, Nagahiro Minato, Robert A. Anders, Anne-Lise Børresen-Dale, Jianwei Zhou, Pål Sætrom, Boye Schnack Nielsen, Michaela B. Kirschner, Hans E. Krokan, Vassiliki Papadimitrakopoulou…

    Citation: Journal of Translational Medicine 2016 14:295

    Published on:

  37. Content type: Research

    Bladder cancer (BCa) is among the most commonly diagnosed malignancies worldwide, and due the high rate of post-operative disease recurrence, it is one of the most prevalent in many countries. The development ...

    Authors: Steve Goodison, Osamu Ogawa, Yoshiyuki Matsui, Takashi Kobayashi, Makito Miyake, Sayuri Ohnishi, Kiyohide Fujimoto, Yunfeng Dai, Yoshiko Shimizu, Kazue Tsukikawa, Hideki Furuya and Charles J. Rosser

    Citation: Journal of Translational Medicine 2016 14:287

    Published on:

  38. Content type: Research

    Small cell lung cancers (SCLC) are tumors of neuroendocrine origin. Previous in vitro studies from our laboratory showed that SCLC expresses high levels of the transmembrane dense core vesicle protein IA-2 (is...

    Authors: Huanyu Xu, Tao Cai, Gilberto N. Carmona, Liron Abuhatzira and Abner L. Notkins

    Citation: Journal of Translational Medicine 2016 14:278

    Published on:

  39. Content type: Research

    FEAT is an intracellular protein that potently drives tumorigenesis in vivo. It is only weakly expressed in normal human tissues, including the testis. In contrast, FEAT is aberrantly upregulated in most human...

    Authors: Yan Li, Kyosuke Kobayashi, Marwa M. Mona, Chikako Satomi, Shinji Okano, Hiroyuki Inoue, Kenzaburo Tani and Atsushi Takahashi

    Citation: Journal of Translational Medicine 2016 14:275

    Published on:

  40. Content type: Research

    Mutations in the isocitrate dehydrogenase enzyme are present in a majority of lower-grade gliomas and secondary glioblastomas. This mis-sense mutation results in the neomorphic reduction of isocitrate dehydrog...

    Authors: Gaurav Verma, Suyash Mohan, MacLean P. Nasrallah, Steven Brem, John Y. K. Lee, Sanjeev Chawla, Sumei Wang, Rajakumar Nagarajan, M. Albert Thomas and Harish Poptani

    Citation: Journal of Translational Medicine 2016 14:274

    Published on:

  41. Content type: Research

    We recently demonstrated a positive effect of berberine on nonalcoholic fatty liver disease patients after 16 weeks of treatment by comparing mere lifestyle intervention in type 2 diabetes patients with berber...

    Authors: Xinxia Chang, Zhe Wang, Jinlan Zhang, Hongmei Yan, Hua Bian, Mingfeng Xia, Huandong Lin, Jiandong Jiang and Xin Gao

    Citation: Journal of Translational Medicine 2016 14:266

    Published on:

  42. Content type: Review

    Although important advances in the management of breast cancer (BC) have been recently accomplished, it still constitutes the leading cause of cancer death in women worldwide. BC is a heterogeneous and complex...

    Authors: Maria Amorim, Sofia Salta, Rui Henrique and Carmen Jerónimo

    Citation: Journal of Translational Medicine 2016 14:265

    Published on:

  43. Content type: Research

    Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs. In a previous work we suggested a correlation between levels of salivary psoriasin (...

    Authors: Laura Giusti, Francesca Sernissi, Elena Donadio, Federica Ciregia, Camillo Giacomelli, Gino Giannaccini, Maria Rosa Mazzoni, Antonio Lucacchini and Laura Bazzichi

    Citation: Journal of Translational Medicine 2016 14:262

    Published on:

  44. Content type: Research

    Nonunion is a failure of healing following a bone fracture. Its physiopathology remains partially unclear and the discovery of new mediators could promote the understanding of bone healing.

    Authors: Dominique de Seny, Gaël Cobraiville, Pierre Leprince, Marianne Fillet, Charlotte Collin, Myrielle Mathieu, Jean-Philippe Hauzeur, Valérie Gangji and Michel G. Malaise

    Citation: Journal of Translational Medicine 2016 14:258

    Published on:

  45. Content type: Review

    Idiopathic pulmonary fibrosis (IPF) identifies a specific lung disorder characterized by chronic, progressive fibrosing interstitial pneumonia of unknown etiology, which lacks effective treatment. According to...

    Authors: Giulia M. Stella, Alessandra Gentile, Alice Balderacchi, Federica Meloni, Melissa Milan and Silvia Benvenuti

    Citation: Journal of Translational Medicine 2016 14:256

    Published on:

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:194

  46. Content type: Research

    Epigenetic silencing mediated by CpG island methylation is a common feature of many cancers. Characterizing aberrant DNA methylation changes associated with prostate carcinogenesis could potentially identify a...

    Authors: Giorgia Gurioli, Samanta Salvi, Filippo Martignano, Flavia Foca, Roberta Gunelli, Matteo Costantini, Giacomo Cicchetti, Ugo De Giorgi, Persio Dello Sbarba, Daniele Calistri and Valentina Casadio

    Citation: Journal of Translational Medicine 2016 14:249

    Published on:

  47. Content type: Research

    Severe early childhood caries (s-ECC), which has quite high prevalence among children, is a widespread problem with significant impacts among both developing and developed countries. At present, it is widely k...

    Authors: Xiangyu Sun, Xin Huang, Xu Tan, Yan Si, Xiaozhe Wang, Feng Chen and Shuguo Zheng

    Citation: Journal of Translational Medicine 2016 14:240

    Published on:

  48. Content type: Research

    NK cell cytotoxicity is regulated by the types of the interaction between killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I ligands on target cells and the different binding...

    Authors: Angelica Canossi, Anna Aureli, Tiziana Del Beato, Piero Rossi, Luana Franceschilli, Flavio De Sanctis, Pierpaolo Sileri, Nicola di Lorenzo, Oreste Buonomo, Davide Lauro, Adriano Venditti and Giuseppe Sconocchia

    Citation: Journal of Translational Medicine 2016 14:239

    Published on:

Annual Journal Metrics

Advertisement