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Clinical translation

Section edited by Lana Kandalaft

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

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  1. Chronic inflammation may contribute to insulin resistance (IR), metabolic syndrome and atherosclerosis although evidence of causality is lacking in humans. We hypothesized that very low-dose experimental endot...

    Authors: Nehal N Mehta, Sean P Heffron, Parth N Patel, Jane Ferguson, Rachana D Shah, Christine C Hinkle, Parasuram Krishnamoorthy, Rhia Shah, Jennifer Tabita-Martinez, Karen Terembula, Stephen R Master, Michael R Rickels and Muredach P Reilly

    Citation: Journal of Translational Medicine 2012 10:124

    Content type: Research

    Published on:

  2. The potent ribonucleotide reductase (RNR) inhibitor 3-aminopyridine-2-carboxyaldehyde-thiosemicarbazone (3-AP) was tested as a chemosensitizer for restored cisplatin-mediated cytotoxicity in platinum-resistant...

    Authors: Charles Kunos, Tomas Radivoyevitch, Fadi W Abdul-Karim, James Fanning, Ovadia Abulafia, Albert J Bonebrake and Lydia Usha

    Citation: Journal of Translational Medicine 2012 10:79

    Content type: Research

    Published on:

  3. Nearly one-third of the United States adult population suffers from hypertension. Hydrochlorothiazide (HCTZ), one of the most commonly used medications to treat hypertension, has variable efficacy. The renal e...

    Authors: Julio D Duarte, Issam Zineh, Ben Burkley, Yan Gong, Taimour Y Langaee, Stephen T Turner, Arlene B Chapman, Eric Boerwinkle, John G Gums, Rhonda M Cooper-DeHoff, Amber L Beitelshees, Kent R Bailey, Roger B Fillingim, Bruce C Kone and Julie A Johnson

    Citation: Journal of Translational Medicine 2012 10:56

    Content type: Research

    Published on:

  4. To determine whether office, home, ambulatory daytime and nighttime blood pressure (BP) responses to antihypertensive drug therapy measure the same signal and which method provides greatest power to identify g...

    Authors: Stephen T Turner, Gary L Schwartz, Arlene B Chapman, Amber L Beitelshees, John G Gums, Rhonda M Cooper-DeHoff, Eric Boerwinkle, Julie A Johnson and Kent R Bailey

    Citation: Journal of Translational Medicine 2012 10:47

    Content type: Research

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  5. Concomitant with the development of in vitro diagnostic multivariate index assays (IVDMIAs) to improve the diagnostic efficiency of ovarian cancer detection is the need to identify appropriate biostatistical appr...

    Authors: Dominic J Autelitano, Linda Raineri, Kate Knight, Kelly Bannister and Gregory E Rice

    Citation: Journal of Translational Medicine 2012 10:45

    Content type: Research

    Published on:

  6. Programmed cell death 6 (PDCD6) beside its known proapoptotic functions may be a player in survival pathways in cancer. The purpose of this study is to further explore the roles of PDCD6 in epithelial ovarian ...

    Authors: Dan Su, Haiyan Xu, Jianguo Feng, Yun Gao, Linhui Gu, Lisha Ying, Dionyssios Katsaros, Herbert Yu, Shenhua Xu and Ming Qi

    Citation: Journal of Translational Medicine 2012 10:31

    Content type: Research

    Published on:

  7. Prognostic index for survival estimation by clinical-demographic variables were previously proposed in chronic lymphocytic leukemia (CLL) patients. Our objective was to test in a large retrospective cohort of ...

    Authors: Pietro Bulian, Davide Rossi, Francesco Forconi, Giovanni Del Poeta, Francesco Bertoni, Emanuele Zucca, Marco Montillo, Gabriele Pozzato, Giovanni D'Arena, Dimitar G Efremov, Roberto Marasca, Francesco Lauria, Gianluca Gaidano, Valter Gattei and Luca Laurenti

    Citation: Journal of Translational Medicine 2012 10:18

    Content type: Research

    Published on:

  8. Results from large epidemiologic studies on the association between vitamin D and gastric cancer are controversial. Vitamin D significantly promotes apoptosis in the undifferentiated gastric cancer cell, but t...

    Authors: Chao Ren, Miao-zhen Qiu, De-shen Wang, Hui-yan Luo, Dong-sheng Zhang, Zhi-qiang Wang, Feng-hua Wang, Yu-hong Li, Zhi-wei Zhou and Rui-hua Xu

    Citation: Journal of Translational Medicine 2012 10:16

    Content type: Research

    Published on:

  9. Overcoming the notorious apoptotic resistance of melanoma cells remains a therapeutic challenge given dismal survival of patients with metastatic melanoma. However, recent clinical trials using a BRAF inhibito...

    Authors: Jianzhong Qin, Hong Xin and Brian J Nickoloff

    Citation: Journal of Translational Medicine 2012 10:15

    Content type: Research

    Published on:

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