Immunovirology

Section edited by Luigi Buonaguro

The Immunovirology section focuses on translational research related to virology and immunity to virus-based diseases, with a particular interest in human oncogenic viruses.

Studies focused on the role of innate, as well as adaptive, immunity in the establishment, containment and/or progression of viral infections up to cancer, including vaccine and adjuvanting strategies, will be considered for publication. Classic immunology as well as more recent, less established "omics" approaches (genomics, proteomics, immunogenomics, pharmacogenomics) will also be considered.

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  1. Research

    Increased T cell breadth and antibody response elicited in prime-boost regimen by viral vector encoded homologous SIV Gag/Env in outbred CD1 mice

    A major obstacle for the development of HIV vaccines is the virus’ worldwide sequence diversity. Nevertheless, the presence of T cell epitopes within conserved regions of the virus’ structural Gag protein and ...

    Anne-Marie Carola Andersson and Peter Johannes Holst

    Journal of Translational Medicine 2016 14:343

    Published on: 20 December 2016

  2. Research

    Performance evaluation of the touchscreen-based Muse™ Auto CD4/CD4% single-platform system for CD4 T cell numeration in absolute number and in percentage using blood samples from children and adult patients living in the Central African Republic

    The new microcapillary and fluorescence-based EC IVD-qualified Muse™ Auto CD4/CD4% single-platform assay (EMD Millipore Corporation, Merck Life Sciences, KGaA, Darmstadt, Germany) for CD4 T cell numeration in ...

    Christian Diamant Mossoro-Kpinde, André Kouabosso, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Edouard Kokanzo, Rosine Féissona, Gérard Grésenguet and Laurent Bélec

    Journal of Translational Medicine 2016 14:326

    Published on: 25 November 2016

  3. Research

    BoHV-4-based vector delivering Ebola virus surface glycoprotein

    Ebola virus (EBOV) is a Category A pathogen that is a member of Filoviridae family that causes hemorrhagic fever in humans and non-human primates. Unpredictable and devastating outbreaks of disease have recently ...

    Alfonso Rosamilia, Sarah Jacca, Giulia Tebaldi, Silvia Tiberti, Valentina Franceschi, Francesca Macchi, Sandro Cavirani, Gary Kobinger, Donald P. Knowles and Gaetano Donofrio

    Journal of Translational Medicine 2016 14:325

    Published on: 24 November 2016

  4. Research

    Serum IgG against Simian Virus 40 antigens are hampered by high levels of sHLA-G in patients affected by inflammatory neurological diseases, as multiple sclerosis

    Many investigators detected the simian polyomavirus SV40 footprints in human brain tumors and neurologic diseases and recently it has been indicated that SV40 seems to be associated with multiple sclerosis (MS...

    Roberta Rizzo, Silvia Pietrobon, Elisa Mazzoni, Daria Bortolotti, Fernanda Martini, Massimiliano Castellazzi, Ilaria Casetta, Enrico Fainardi, Dario Di Luca, Enrico Granieri and Mauro Tognon

    Journal of Translational Medicine 2016 14:216

    Published on: 22 July 2016

  5. Methodology

    Validation of an IFNγ/IL2 FluoroSpot assay for clinical trial monitoring

    The FluoroSpot assay, an advancement of the ELISpot assay, enables simultaneous measurement of different analytes secreted at a single-cell level. This allows parallel detection of several cytokines secreted b...

    Nina Körber, Uta Behrends, Alexander Hapfelmeier, Ulrike Protzer and Tanja Bauer

    Journal of Translational Medicine 2016 14:175

    Published on: 14 June 2016

  6. Research

    The MHC-II transactivator CIITA inhibits Tat function and HIV-1 replication in human myeloid cells

    We previously demonstrated that the HLA class II transactivator CIITA inhibits HIV-1 replication in T cells by competing with the viral transactivator Tat for the binding to Cyclin T1 subunit of the P-TEFb com...

    Greta Forlani, Filippo Turrini, Silvia Ghezzi, Alessandra Tedeschi, Guido Poli, Roberto S. Accolla and Giovanna Tosi

    Journal of Translational Medicine 2016 14:94

    Published on: 18 April 2016

  7. Research

    Analysis of cellular and humoral immune responses against cytomegalovirus in patients with autoimmune Addison’s disease

    Autoimmune Addison’s disease (AAD) is caused by multiple genetic and environmental factors. Variants of genes encoding immunologically important proteins such as the HLA molecules are strongly associated with ...

    Kine Edvardsen, Alexander Hellesen, Eystein S. Husebye and Eirik Bratland

    Journal of Translational Medicine 2016 14:68

    Published on: 9 March 2016

  8. Research

    A novel multi-drug metronomic chemotherapy significantly delays tumor growth in mice

    The tumor immunosuppressive microenvironment represents a major obstacle to an effective tumor-specific cellular immune response.

    Maria Tagliamonte, Annacarmen Petrizzo, Maria Napolitano, Antonio Luciano, Domenica Rea, Antonio Barbieri, Claudio Arra, Piera Maiolino, Marialina Tornesello, Gennaro Ciliberto, Franco M. Buonaguro and Luigi Buonaguro

    Journal of Translational Medicine 2016 14:58

    Published on: 24 February 2016

  9. Methodology

    Kinetics of human myeloid-derived suppressor cells after blood draw

    Human myeloid-derived suppressor cells (MDSC) have been described as a group of immature myeloid cells which exert immunosuppressive action by inhibiting function of T lymphocytes. While there is a huge scient...

    Eva Grützner, Renate Stirner, Lukas Arenz, Anastasia P. Athanasoulia, Kathrin Schrödl, Carola Berking, Johannes R. Bogner and Rika Draenert

    Journal of Translational Medicine 2016 14:2

    Published on: 6 January 2016

  10. Research

    Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative

    HPV infections are detected in sexually naive children. This has raised the question about the role of early HPV infections in either protecting or predisposing to further HPV infections. HPV16-specific cell-m...

    Hanna-Mari Koskimaa, Anna Paaso, Marij J. P. Welters, Seija Grénman, Kari Syrjänen, Sjoerd H. van der Burg and Stina Syrjänen

    Journal of Translational Medicine 2015 13:370

    Published on: 25 November 2015

  11. Research

    Cotton rat immune responses to virus-like particles containing the pre-fusion form of respiratory syncytial virus fusion protein

    Virus-like particles (VLPs) based on Newcastle disease virus (NDV) core proteins, M and NP, and containing two chimera proteins, F/F and H/G, composed of the respiratory syncytial virus (RSV) fusion protein (F...

    Lori McGinnes Cullen, Jorge C. G. Blanco and Trudy G. Morrison

    Journal of Translational Medicine 2015 13:350

    Published on: 5 November 2015

  12. Research

    Effect of deworming on Th2 immune response during HIV-helminths co-infection

    Helminths infections have been suggested to worsen the outcome of HIV infection by polarizing the immune response towards Th2. The purpose of this study is to determine the activity of Th2 immune response by m...

    Andargachew Mulu, Belay Anagaw, Aschalew Gelaw, Fuso Ota, Afework Kassu and Sisay Yifru

    Journal of Translational Medicine 2015 13:236

    Published on: 18 July 2015

  13. Research

    Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

    High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. Howe...

    Marta Massanella, Elisabet Gómez-Mora, Jorge Carrillo, Marta Curriu, Dan Ouchi, Jordi Puig, Eugènia Negredo, Cecilia Cabrera, Bonaventura Clotet and Julià Blanco

    Journal of Translational Medicine 2015 13:230

    Published on: 17 July 2015

  14. Research

    A thermostable, chromatographically purified Ebola nano-VLP vaccine

    Filovirus virus-like particles (VLP) are strong immunogens with the potential for development into a safe, non-infectious vaccine. However, the large size and filamentous structure of this virus has heretofore...

    John H Carra, Karen A O Martins, Rowena D Schokman, Camenzind G Robinson, Jesse T Steffens and Sina Bavari

    Journal of Translational Medicine 2015 13:228

    Published on: 15 July 2015

  15. Research

    Association between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study

    Interleukin-7 (IL-7) is a critical factor for T cell development and for maintaining and restoring homeostasis of mature T cells. Polymorphisms at α-chain of the IL-7 receptor (IL7R or CD127) gene are related ...

    María Guzmán-Fulgencio, Juan Berenguer, María A Jiménez-Sousa, Daniel Pineda-Tenor, Teresa Aldámiz-Echevarria, Pilar García-Broncano, Ana Carrero, Mónica García-Álvarez, Francisco Tejerina, Cristina Diez, Sonia Vazquez-Morón and Salvador Resino

    Journal of Translational Medicine 2015 13:206

    Published on: 30 June 2015

  16. Research

    An autophagosome-based therapeutic vaccine for HBV infection: a preclinical evaluation

    For more than 240 million chronic HBV carriers worldwide, effective therapeutic HBV vaccines are urgently needed. Recently, we demonstrated that autophagosomes were efficient antigens carriers and capable to c...

    Meng Xue, Fei Fan, Lei Ding, Jingyu Liu, Shu Su, Pengfei Yin, Meng Cao, Wei Zhao, Hong-ming Hu and Lixin Wang

    Journal of Translational Medicine 2014 12:361

    Published on: 20 December 2014

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