Neuroscience

Section edited by Luis F. Alguacil

The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field.

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  1. Research

    Novel neuro-audiological findings and further evidence for TWNK involvement in Perrault syndrome

    Hearing loss and ovarian dysfunction are key features of Perrault syndrome (PRLTS) but the clinical and pathophysiological features of hearing impairment in PRLTS individuals have not been addressed. Mutations...

    Monika Ołdak, Dominika Oziębło, Agnieszka Pollak, Iwona Stępniak, Michal Lazniewski, Urszula Lechowicz, Krzysztof Kochanek, Mariusz Furmanek, Grażyna Tacikowska, Dariusz Plewczynski, Tomasz Wolak, Rafał Płoski and Henryk Skarżyński

    Journal of Translational Medicine 2017 15:25

    Published on: 8 February 2017

  2. Research

    Sodium ferulate and n-butylidenephthalate combined with bone marrow stromal cells (BMSCs) improve the therapeutic effects of angiogenesis and neurogenesis after rat focal cerebral ischemia

    Studies have indicated that bone marrow stromal cell (BMSC) administration is a promising approach for stroke treatment. For our study, we chose sodium ferulate (SF) and n-butylidenephthalide (BP) combined with B...

    Qian Zhang, Yonghua Zhao, Youhua Xu, Zhenwei Chen, Naiwei Liu, Chienchih Ke, Bowen Liu and Weikang Wu

    Journal of Translational Medicine 2016 14:223

    Published on: 28 July 2016

  3. Research

    Longitudinal brain structural alterations and systemic inflammation in obstructive sleep apnea before and after surgical treatment

    Systemic inflammation, neurocognitive impairments, and morphologic brain changes are associated with obstructive sleep apnea (OSA). Understanding their longitudinal evolution and interactions after surgical tr...

    Wei-Che Lin, Chih-Cheng Huang, Hsiu-Ling Chen, Kun-Hsien Chou, Pei-Chin Chen, Nai-Wen Tsai, Meng-Hsiang Chen, Michael Friedman, Hsin-Ching Lin and Cheng-Hsien Lu

    Journal of Translational Medicine 2016 14:139

    Published on: 17 May 2016

  4. Research

    Effects of vagus nerve stimulation on cognitive functioning in rats with cerebral ischemia reperfusion

    Vagus nerve stimulation (VNS) has become the most common non-pharmacological treatment for intractable drug-resistant epilepsy. However, the contribution of VNS to neurological rehabilitation following stroke ...

    Ai-fen Liu, Feng-bo Zhao, Jing Wang, Yi-Fan Lu, Jian Tian, Yin Zhao, Yan Gao, Xia-jun Hu, Xiao-yan Liu, Jie Tan, Yun-li Tian and Jing Shi

    Journal of Translational Medicine 2016 14:101

    Published on: 27 April 2016

  5. Research

    Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study

    It is generally acknowledged that drug dependence is connected with abnormal functional organization in the individual’s brain. The present study aimed to identify the anterior cingulate cortex (ACC) abnormali...

    Tao Liu, Jianjun Li, Zhongyan Zhao, Yuan Zhong, Zhiqiang Zhang, Qiang Xu, Guoshuai Yang, Guangming Lu, Suyue Pan and Feng Chen

    Journal of Translational Medicine 2016 14:33

    Published on: 2 February 2016

  6. Research

    Exome sequencing identifies a mutation in TMC1 as a novel cause of autosomal recessive nonsyndromic hearing loss

    Autosomal recessive non-syndromic hearing loss (ARNSHL) is highly heterogeneous, and mutations in the gene encoding transmembrane channel-like 1 (TMC1) have been implicated in its development. To date, 35 homo...

    Jiongjiong Hu, Fei Liu, Wenjun Xia, Lili Hao, Jun Lan, Zhenghua Zhu, Jing Ye, Duan Ma and Zhaoxin Ma

    Journal of Translational Medicine 2016 14:29

    Published on: 28 January 2016

  7. Research

    NGF eye-drops topical administration in patients with retinitis pigmentosa, a pilot study

    Preclinical trials have shown beneficial effects of nerve growth factor (NGF) administration on visual function in animal models of retinitis pigmentosa (RP). The aim of this pilot study was to explore the po...

    Benedetto Falsini, Giancarlo Iarossi, Antonio Chiaretti, Antonio Ruggiero, Luigi Manni, Lucia Galli-Resta, Giovanni Corbo and Edoardo Abed

    Journal of Translational Medicine 2016 14:8

    Published on: 9 January 2016

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:43

  8. Research

    Brain mediators of systemic oxidative stress on perceptual impairments in Parkinson’s disease

    Parkinson’s disease (PD) is well documented to be associated with elevated systemic oxidative stress and perceptual impairments. Furthermore, the striatum and extrastriatal cortical areas, which are involved i...

    Wei-Che Lin, Kun-Hsien Chou, Pei-Lin Lee, Yung-Cheng Huang, Nai-Wen Tsai, Hsiu-Ling Chen, Kuei-Yueh Cheng, Hung-Chen Wang, Tsu-Kung Lin, Shau-Hsuan Li, Meng-Hsiang Chen, Cheng-Hsien Lu and Ching-Po Lin

    Journal of Translational Medicine 2015 13:386

    Published on: 21 December 2015

  9. Research

    Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1

    There is a paucity of effective therapies for recurrent/aggressive meningiomas. Establishment of improved in vitro and in vivo meningioma models will facilitate development and testing of novel therapeutic app...

    Sharon K Michelhaugh, Anthony R Guastella, Kaushik Varadarajan, Neil V Klinger, Prahlad Parajuli, Aamir Ahmad, Seema Sethi, Amro Aboukameel, Sam Kiousis, Ian M Zitron, Salah A Ebrahim, Lisa A Polin, Fazlul H Sarkar, Aliccia Bollig-Fischer and Sandeep Mittal

    Journal of Translational Medicine 2015 13:227

    Published on: 15 July 2015

  10. Research

    Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study

    Schizophrenia is a widespread and debilitating mental disorder. However, the underlying molecular mechanism of schizophrenia remains largely unknown and no objective laboratory tests are available to diagnose ...

    Mei-Ling Liu, Xiao-Tong Zhang, Xiang-Yu Du, Zheng Fang, Zhao Liu, Yi Xu, Peng Zheng, Xue-Jiao Xu, Peng-Fei Cheng, Ting Huang, Shun-Jie Bai, Li-Bo Zhao, Zhi-Guo Qi, Wei-Hua Shao and Peng Xie

    Journal of Translational Medicine 2015 13:226

    Published on: 14 July 2015

  11. Research

    Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret

    Rodents are incapable of emesis and consequently the emetic potential of glucagon-like peptide-1 receptor (GLP-1R) agonists in studies designed to assess a potential blood glucose lowering action of the compou...

    Zengbing Lu, Nathalie Percie Du Sert, Sze Wa Chan, Chi-Kong Yeung, Ge Lin, David TW Yew, Paul LR Andrews and John A Rudd

    Journal of Translational Medicine 2014 12:327

    Published on: 10 December 2014

  12. Research

    Growth factor-eluting cochlear implant electrode: impact on residual auditory function, insertional trauma, and fibrosis

    A cochlear implant (CI) is an artificial hearing device that can replace a damaged cochlea. The present study examined the use of growth factor-eluting gelatin hydrogel coatings on the electrodes to minimize i...

    Yayoi S Kikkawa, Takayuki Nakagawa, Lin Ying, Yasuhiko Tabata, Hirohito Tsubouchi, Akio Ido and Juichi Ito

    Journal of Translational Medicine 2014 12:280

    Published on: 4 October 2014

  13. Research

    Biochemical and inflammatory biomarkers in ischemic stroke: translational study between humans and two experimental rat models

    our objective was to examine the plasma levels of three biological markers involved in cerebral ischemia (IL-6, glutamate and TNF-alpha) in stroke patients and compare them with two different rat models of foc...

    Patricia Martínez-Sánchez, María Gutiérrez-Fernández, Blanca Fuentes, Jaime Masjuán, María Alonso de Leciñana Cases, Maria Elena Novillo-López and Exuperio Díez-Tejedor

    Journal of Translational Medicine 2014 12:220

    Published on: 3 August 2014

  14. Research

    Existence of a potential neurogenic system in the adult human brain

    Prevailingly, adult mammalian neurogenesis is thought to occur in discrete, separate locations known as neurogenic niches that are best characterized in the subgranular zone (SGZ) of the dentate gyrus and in t...

    Adriano Barreto Nogueira, Mari Cleide Sogayar, Alison Colquhoun, Sheila Aparecida Siqueira, Ariel Barreto Nogueira, Paulo Eurípedes Marchiori and Manoel Jacobsen Teixeira

    Journal of Translational Medicine 2014 12:75

    Published on: 22 March 2014

  15. Research

    Developing regional genetic counseling for southern Chinese with nonsyndromic hearing impairment: a unique mutational spectrum

    Racial and regional factors are important for the clinical diagnosis of non-syndromic hearing impairment. Comprehensive genetic analysis of deaf patients in different regions of China must be performed to prov...

    Kaitian Chen, Ling Zong, Min Liu, Xianren Wang, Wei Zhou, Yuan Zhan, Hui Cao, Chang Dong, Haocheng Tang and Hongyan Jiang

    Journal of Translational Medicine 2014 12:64

    Published on: 11 March 2014

  16. Research

    Novel compound heterozygous mutations in the MYO15A gene in autosomal recessive hearing loss identified by whole-exome sequencing

    Inherited genetic defects play an important role in congenital hearing loss, contributing to about 60% of deafness occurring in infants. Hereditary nonsyndromic hearing loss is highly heterogeneous, and most p...

    Xue Gao, Qing-yan Zhu, Yue-Shuai Song, Guo-Jian Wang, Yong-Yi Yuan, Feng Xin, Sha-Sha Huang, Dong-Yang Kang, Ming-Yu Han, Li-ping Guan, Jian-guo Zhang and Pu Dai

    Journal of Translational Medicine 2013 11:284

    Published on: 9 November 2013

  17. Research

    MiRNA-329 targeting E2F1 inhibits cell proliferation in glioma cells

    MicroRNAs have recently emerged as key regulators of cancers, miR-329 located on 14q32.31 is one of down-regulated miRNAs in glioma, but the function and molecular mechanisms of miR-329 in determining the mali...

    Bingxiang Xiao, Li Tan, Benfu He, Zhiliang Liu and Ruxiang Xu

    Journal of Translational Medicine 2013 11:172

    Published on: 17 July 2013

  18. Methodology

    Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

    Neurodegenerative diseases such as Alzheimer’s are associated with the aggregation of endogenous peptides and proteins that contribute to neuronal dysfunction and loss. The glymphatic system, a brain-wide peri...

    Lijun Yang, Benjamin T Kress, Harris J Weber, Meenakshisundaram Thiyagarajan, Baozhi Wang, Rashid Deane, Helene Benveniste, Jeffrey J Iliff and Maiken Nedergaard

    Journal of Translational Medicine 2013 11:107

    Published on: 1 May 2013

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