Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

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  1. Methodology

    Realising stratified psychiatry using multidimensional signatures and trajectories

    Stratified or personalised medicine targets treatments for groups of individuals with a disorder based on individual heterogeneity and shared factors that influence the likelihood of response. Psychiatry has ...

    Dan W. Joyce, Angie A. Kehagia, Derek K. Tracy, Jessica Proctor and Sukhwinder S. Shergill

    Journal of Translational Medicine 2017 15:15

    Published on: 18 January 2017

  2. Research

    Flow diverter effect of LVIS stent on cerebral aneurysm hemodynamics: a comparison with Enterprise stents and the Pipeline device

    The aim of this study was to quantify the effect of the new Low-profile Visualized Intraluminal Support (LVIS®D) device and the difference of fluid diverting effect compared with the Pipeline device and the En...

    Chao Wang, Zhongbin Tian, Jian Liu, Linkai Jing, Nikhil Paliwal, Shengzhang Wang, Ying Zhang, Jianping Xiang, Adnan H. Siddiqui, Hui Meng and Xinjian Yang

    Journal of Translational Medicine 2016 14:199

    Published on: 2 July 2016

  3. Research

    Identification of potential biomarkers to differentially diagnose solid pseudopapillary tumors and pancreatic malignancies via a gene regulatory network

    Solid pseudopapillary neoplasms (SPN) are pancreatic tumors with low malignant potential and good prognosis. However, differential diagnosis between SPN and pancreatic malignancies including pancreatic neuroe...

    Pengping Li, Yuebing Hu, Jiao Yi, Jie Li, Jie Yang and Jin Wang

    Journal of Translational Medicine 2015 13:361

    Published on: 14 November 2015

  4. Research

    Global comparison of chromosome X genes of pulmonary telocytes with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes

    Telocytes (TCs) are suggested as a new type of interstitial cells with specific telopodes. Our previous study evidenced that TCs differed from fibroblasts and stem cells at the aspect of gene expression profil...

    Yichun Zhu, Minghuan Zheng, Dongli Song, Ling Ye and Xiangdong Wang

    Journal of Translational Medicine 2015 13:318

    Published on: 28 September 2015

  5. Research

    The effect of socioeconomic status on health-care delay and treatment of esophageal cancer

    Socioeconomic status (SES) has been focused on as a key determinant of the incidence of cancer, cancer stage at diagnosis as well as treatment choices in western countries. However, to the authors’ knowledge, ...

    Nana Wang, Fangli Cao, Fang Liu, Yibin Jia, Jianbo Wang, Cihang Bao, Xintong Wang, Qingxu Song, Bingxu Tan and Yufeng Cheng

    Journal of Translational Medicine 2015 13:241

    Published on: 24 July 2015

  6. Methodology

    A workflow-driven approach to integrate generic software modules in a Trusted Third Party

    Cohort studies and registries rely on massive amounts of personal medical data. Therefore, data protection and information security as well as ethical aspects gain in importance and need to be considered as ea...

    Martin Bialke, Peter Penndorf, Tim Wegner, Thomas Bahls, Christoph Havemann, Jens Piegsa and Wolfgang Hoffmann

    Journal of Translational Medicine 2015 13:176

    Published on: 4 June 2015

  7. Methodology

    Diagnosis of 25 genotypes of human papillomaviruses for their physical statuses in cervical precancerous/cancerous lesions: a comparison of E2/E6E7 ratio-based vs. multiple E1-L1/E6E7 ratio-based detection techniques

    Cervical lesions caused by integrated human papillomavirus (HPV) infection are highly dangerous because they can quickly develop into invasive cancers. However, clinicians are currently hampered by the lack of...

    Rong Zhang, Yi-feng He, Mo Chen, Chun-mei Chen, Qiu-jing Zhu, Huan Lu, Zhen-hong Wei, Fang Li, Xiao-xin Zhang, Cong-jian Xu and Long Yu

    Journal of Translational Medicine 2014 12:282

    Published on: 2 October 2014

  8. Research

    Modeling interactions between Human Equilibrative Nucleoside Transporter-1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients

    Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by largely unsatisfactory responses to the currently available therapeutic strategies. In this study we evaluated th...

    Francesca Tavano, Andrea Fontana, Fabio Pellegrini, Francesca Paola Burbaci, Francesca Rappa, Francesco Cappello, Massimiliano Copetti, Evaristo Maiello, Lucia Lombardi, Paolo Graziano, Manlio Vinciguerra, Fabio Francesco di Mola, Pierluigi di Sebastiano, Angelo Andriulli and Valerio Pazienza

    Journal of Translational Medicine 2014 12:248

    Published on: 10 September 2014

  9. Research

    Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics

    Clozapine is highly effective in treatment-resistant schizophrenia, although, there remains significant variability in the response to this drug. To better understand this variability, the objective of this st...

    Claire H Li, Robert E Stratford, Nieves Velez de Mendizabal, Thomas IFH Cremers, Bruce G Pollock, Benoit H Mulsant, Gary Remington and Robert R Bies

    Journal of Translational Medicine 2014 12:203

    Published on: 20 August 2014

  10. Methodology

    A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability

    Numerous inflammation-related pathways have been shown to play important roles in atherogenesis. Rapid and efficient assessment of the relative influence of each of those pathways is a challenge in the era of ...

    Héctor De León, Stéphanie Boué, Walter K Schlage, Natalia Boukharov, Jurjen W Westra, Stephan Gebel, Aaron VanHooser, Marja Talikka, R Brett Fields, Emilija Veljkovic, Michael J Peck, Carole Mathis, Vy Hoang, Carine Poussin, Renee Deehan, Katrin Stolle…

    Journal of Translational Medicine 2014 12:185

    Published on: 26 June 2014

  11. Research

    Characteristics of TCM constitutions of adult Chinese women in Hong Kong and identification of related influencing factors: a cross-sectional survey

    Traditional Chinese Medicine Constitution (TCMC) refers to an integrated, metastable and natural specialty of individual in morphosis, physiological functions and psychological conditions. It is formed on the ...

    Youzhi Sun, Pei Liu, Yi Zhao, Lei Jia, Yanhua He, Steve An Xue, Xiao Zheng, Zhiyu Wang, Neng Wang and Jianping Chen

    Journal of Translational Medicine 2014 12:140

    Published on: 21 May 2014

  12. Research

    Modeling the transmission of community-associated methicillin-resistant Staphylococcus aureus: a dynamic agent-based simulation

    Methicillin-resistant Staphylococcus aureus (MRSA) has been a deadly pathogen in healthcare settings since the 1960s, but MRSA epidemiology changed since 1990 with new genetically distinct strain types circulatin...

    Charles M Macal, Michael J North, Nicholson Collier, Vanja M Dukic, Duane T Wegener, Michael Z David, Robert S Daum, Philip Schumm, James A Evans, Jocelyn R Wilder, Loren G Miller, Samantha J Eells and Diane S Lauderdale

    Journal of Translational Medicine 2014 12:124

    Published on: 12 May 2014

  13. Research

    Nonspecific changes in clinical laboratory indicators in unselected terminally ill patients and a model to predict survival time based on a prospective observational study

    The clinical prediction of survival is among the most challenging tasks because it refers to the process whereby the medical team assimilates clinical data using subjective methods. The purpose of this prospec...

    Liu Hui, Liu Qigui, Ren Sashuang, Liu Xiliang and Luan Guihong

    Journal of Translational Medicine 2014 12:78

    Published on: 22 March 2014

  14. Research

    Genetic mutations in nonsyndromic deafness patients of Chinese minority and han ethnicities in Yunnan, China

    Each year in China, 30,000 babies are born with congenital hearing impairment. However, the molecular etiology of hearing impairment in the Yunnan Province population where more than 52 minorities live has not...

    Feng Xin, Yongyi Yuan, Xiaoming Deng, Mingyu Han, Guojian Wang, Jiandong Zhao, Xue Gao, Jun Liu, Fei Yu, Dongyi Han and Pu Dai

    Journal of Translational Medicine 2013 11:312

    Published on: 17 December 2013

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