Translational imaging

Section edited by Ravinder Reddy

The Translational Imaging section provides a platform for rapid dissemination of the advances in medical imaging research emphasizing clinical translation. The topics covered in this section will include methodological innovations in early diagnoses of human diseases and monitoring of therapeutic responses from all the major imaging modalities (MRI, PET, US etc.,). Articles considered for publication include studies in human subjects, pre-clinical models and ex vivo systems dealing with imaging of human pathophysiologies.

  1. Research

    Monitoring inflammation and airway remodeling by fluorescence molecular tomography in a chronic asthma model

    Asthma is a multifactorial disease for which a variety of mouse models have been developed. A major drawback of these models is represented by the transient nature of the airway pathology peaking 24–72 h after...

    Fabio Stellari, Angelo Sala, Francesca Ruscitti, Chiara Carnini, Prisco Mirandola, Marco Vitale, Maurizio Civelli and Gino Villetti

    Journal of Translational Medicine 2015 13:336

    Published on: 24 October 2015

  2. Research

    Reduced cortical thickness in patients with acute-on-chronic liver failure due to non-alcoholic etiology

    Acute-on-chronic liver failure (ACLF) is a form of liver disease with high short-term mortality. ACLF offers considerable potential to affect the cortical areas by significant tissue injury due to loss of neur...

    Santosh K. Yadav, Rakesh K. Gupta, Vivek A. Saraswat, Murali Rangan, Michael A. Thomas, Sergio Rutella, Silvio Danese, Ena Wang, Francesco M. Marincola and Mohammad Haris

    Journal of Translational Medicine 2015 13:322

    Published on: 6 October 2015

  3. Research

    Diffuse reflectance spectroscopy accurately quantifies various degrees of liver steatosis in murine models of fatty liver disease

    A real-time objective evaluation for the extent of liver steatosis during liver transplantation is currently not available. Diffuse reflectance spectroscopy (DRS) rapidly and accurately assesses the extent of...

    Andrie C. Westerkamp, Vishnu V. Pully, Golnar Karimian, Fernanda Bomfati, Zwanida J. Veldhuis, Janneke Wiersema-Buist, Benno H. W. Hendriks, Ton Lisman and Robert J. Porte

    Journal of Translational Medicine 2015 13:309

    Published on: 21 September 2015

  4. Research

    T1ρ MRI of healthy and fibrotic human livers at 1.5 T

    Liver fibrosis is a public health problem worldwide. There is a need of noninvasive imaging based methods for better diagnosis of this disease. In the current study, we aim to evaluate the potential of T1ρ MRI...

    Anup Singh, Damodar Reddy, Mohammad Haris, Kejia Cai, K. Rajender Reddy, Hari Hariharan and Ravinder Reddy

    Journal of Translational Medicine 2015 13:292

    Published on: 8 September 2015

  5. Methodology

    Correlation between μCT imaging, histology and functional capacity of the osteoarthritic knee in the rat model of osteoarthritis

    To acquire the most meaningful understanding of human arthritis, it is essential to select the disease model and methodology translatable to human conditions. The primary objective of this study was to evaluat...

    Cedo M. Bagi, David E. Zakur, Edwin Berryman, Catharine J. Andresen and Dean Wilkie

    Journal of Translational Medicine 2015 13:276

    Published on: 25 August 2015

  6. Research

    In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa and its modulation by azithromycin

    Chronic inflammation of the airways is a central component in lung diseases and is frequently associated with bacterial infections. Monitoring the pro-inflammatory capability of bacterial virulence factors in ...

    Fabio Stellari, Gabriella Bergamini, Angela Sandri, Gaetano Donofrio, Claudio Sorio, Francesca Ruscitti, Gino Villetti, Barouk M Assael, Paola Melotti and Maria M Lleo

    Journal of Translational Medicine 2015 13:251

    Published on: 4 August 2015